2EVCA

Crystal structure of e. coli. methionine amino peptidase in complex with 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
259
structure length
259
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 85
structure length 259
sequence length 259
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evcA00
4ZNGA 4ZWPA 3TB5A 2Q95A 5D6FA 2BHDA 5D6EA 2GU5A 4MATA 5CDLA 1WLRA 4FLKA 3BIPA 4IU6A 4RZZA 4FUKA 1KQ0A 1KQ9A 3IU9A 2V3ZA 2BH3A 1QZYA 1R5HA 1C24A 3RVAA 4R60A 4ZWOA 2BWXA 3TAVA 5E5BA 2BWYA 2ADUA 1XGSA 2BWTA 3PKEA 4U69A 2GGBA 2BWUA 1N51A 4IPAA 4PNCA 2GA2A 4U6JA 4S2TP 4OOKA 1QXYA 1W7VA 1Y1NA 1WY2A 2GU7A 4IF7A 1CHMA 1YVMA 3CB5A 1B6AA 4FLLA 5CLSA 2V3XA 1YW9A 2GG5A 2P9AA 2Q94A 4U70A 1B59A 4PV4A 4U6ZA 4U76A 2BHBA 2BN7A 2OKNA 1WKMA 1XGOA 1QXWA 1C23A 2GG9A 2IW2A 5CNXA 2P99A 3IG4A 4B28A 4IECA 1PV9A 2GG0A 1C21A 1C27A 2GZ5A 2B3KA 2G6PA 1WL9A 4U73A 3FMRA 3D27A 1C22A 4FKCA 5CDVA 4EGEA 1KP0A 4IKRA 2P98A 1O0XA 1WN1A 2BB7A 3PKBA 3PKDA 2GG7A 1R58A 2EVMA 1XNZA 2GU4A 5JHUA 2BWVA 3IU8A 5CIKA 4ZWUA 1YW8A 4JUQA 4S2RP 5FCHA 3BIQA 3IU7A 1MATA 3L7GA 2BHAA 2Q93A 3MR1A 4S00A 2EA4A 2ZSGA 4IKTA 4KM3A 1WBQA 1W2MA 1R5GA 5CE6A 3BITA 4IKSA 4U71A 4A6VA 5JI6A 3Q6DA 4FLJA 2B3LA 1YJ3A 4RZYA 1YW7A 2B3HA 2DFIA 4Z7MA 1WL6A 4U6EA 4IKUA 3PKAA 3FMQA 4U6CA 2BHCA 4QR8A 1A16A 1BN5A 2HOWA 4IDYA 2NQ7A 2GU6A 2GG3A 4U75A 1BOAA 2GTXA 2MATA 2GG8A 2EVCA 2Q8KA 2BWSA 2EA2A 4A6WA 3L24A 4U1BA 3MATA 2BWWA 1JAWA 1QXZA 2EVOA 4FO7A 4S01A 5CDEA 4FLIA 2OAZA 2V6CA 3RORA 3S6BA 1XGMA 3CB6A 3CTZA 4HXXA 2V3YA 2Q96A 5FCFA 4FO8A 5JFRA 2NQ6A 3FM3A 2GG2A 2Q92A 3MX6A 4U6WA 1XGNA 4RGZ1 3PKCA 1M35A 2GGCA
chains in the Genus database with same CATH superfamily
4ZNGA 4ZWPA 3TB5A 2Q95A 5D6FA 2BHDA 5D6EA 2GU5A 4MATA 5CDLA 1WLRA 4FLKA 3BIPA 4IU6A 4RZZA 4FUKA 1KQ0A 1KQ9A 3IU9A 2V3ZA 2BH3A 1QZYA 1R5HA 1C24A 3RVAA 4R60A 4ZWOA 2BWXA 3TAVA 5E5BA 2BWYA 2ADUA 1XGSA 2BWTA 3PKEA 4U69A 2GGBA 2BWUA 1N51A 4IPAA 4PNCA 2GA2A 4U6JA 4S2TP 4OOKA 1QXYA 1W7VA 1Y1NA 1WY2A 2GU7A 4IF7A 1CHMA 1YVMA 3CB5A 1B6AA 4FLLA 5CLSA 2V3XA 1YW9A 2GG5A 2P9AA 2Q94A 4U70A 1B59A 4PV4A 4U6ZA 4U76A 2BHBA 2BN7A 2OKNA 1WKMA 1XGOA 1QXWA 1C23A 2GG9A 2IW2A 5CNXA 2P99A 3IG4A 4B28A 4IECA 1PV9A 2GG0A 1C21A 1C27A 2GZ5A 2B3KA 2G6PA 1WL9A 4U73A 3FMRA 3D27A 1C22A 4FKCA 5CDVA 4EGEA 1KP0A 4IKRA 2P98A 1O0XA 1WN1A 2BB7A 3PKBA 3PKDA 2GG7A 1R58A 2EVMA 1XNZA 2GU4A 5JHUA 2BWVA 3IU8A 5CIKA 4ZWUA 1YW8A 4JUQA 4S2RP 5FCHA 3BIQA 3IU7A 1MATA 3L7GA 2BHAA 2Q93A 3MR1A 4S00A 2EA4A 2ZSGA 4IKTA 4KM3A 1WBQA 1W2MA 1R5GA 5CE6A 3BITA 4IKSA 4U71A 4A6VA 5JI6A 3Q6DA 4FLJA 2B3LA 1YJ3A 4RZYA 1YW7A 2B3HA 2DFIA 4Z7MA 1WL6A 4U6EA 4IKUA 3PKAA 3FMQA 4U6CA 2BHCA 4QR8A 1A16A 1BN5A 2HOWA 4IDYA 2NQ7A 2GU6A 2GG3A 4U75A 1BOAA 2GTXA 2MATA 2GG8A 2EVCA 2Q8KA 2BWSA 2EA2A 4A6WA 3L24A 4U1BA 3MATA 2BWWA 1JAWA 1QXZA 2EVOA 4FO7A 4S01A 5CDEA 4FLIA 2OAZA 2V6CA 3RORA 3S6BA 1XGMA 3CB6A 3CTZA 4HXXA 2V3YA 2Q96A 5FCFA 4FO8A 5JFRA 2NQ6A 3FM3A 2GG2A 2Q92A 3MX6A 4U6WA 1XGNA 4RGZ1 3PKCA 1M35A 2GGCA
chains in the Genus database with same CATH topology
4ZNGA 4ZWPA 3TB5A 2Q95A 5D6FA 2BHDA 5D6EA 2GU5A 4MATA 5CDLA 1WLRA 4FLKA 3BIPA 4IU6A 4RZZA 4FUKA 1KQ0A 1KQ9A 3IU9A 2V3ZA 2BH3A 1QZYA 1R5HA 1C24A 3RVAA 4R60A 4ZWOA 2BWXA 3TAVA 5E5BA 2BWYA 2ADUA 1XGSA 2BWTA 3PKEA 4U69A 2GGBA 2BWUA 1N51A 4IPAA 4PNCA 2GA2A 4U6JA 4S2TP 4OOKA 1QXYA 1W7VA 1Y1NA 1WY2A 2GU7A 4IF7A 1CHMA 1YVMA 3CB5A 1B6AA 4FLLA 5CLSA 2V3XA 1YW9A 2GG5A 2P9AA 2Q94A 4U70A 1B59A 4PV4A 4U6ZA 4U76A 2BHBA 2BN7A 2OKNA 1WKMA 1XGOA 1QXWA 1C23A 2GG9A 2IW2A 5CNXA 2P99A 3IG4A 4B28A 4IECA 1PV9A 2GG0A 1C21A 1C27A 2GZ5A 2B3KA 2G6PA 1WL9A 4U73A 3FMRA 3D27A 1C22A 4FKCA 5CDVA 4EGEA 1KP0A 4IKRA 2P98A 1O0XA 1WN1A 2BB7A 3PKBA 3PKDA 2GG7A 1R58A 2EVMA 1XNZA 2GU4A 5JHUA 2BWVA 3IU8A 5CIKA 4ZWUA 1YW8A 4JUQA 4S2RP 5FCHA 3BIQA 3IU7A 1MATA 3L7GA 2BHAA 2Q93A 3MR1A 4S00A 2EA4A 2ZSGA 4IKTA 4KM3A 1WBQA 1W2MA 1R5GA 5CE6A 3BITA 4IKSA 4U71A 4A6VA 5JI6A 3Q6DA 4FLJA 2B3LA 1YJ3A 4RZYA 1YW7A 2B3HA 2DFIA 4Z7MA 1WL6A 4U6EA 4IKUA 3PKAA 3FMQA 4U6CA 2BHCA 4QR8A 1A16A 1BN5A 2HOWA 4IDYA 2NQ7A 2GU6A 2GG3A 4U75A 1BOAA 2GTXA 2MATA 2GG8A 2EVCA 2Q8KA 2BWSA 2EA2A 4A6WA 3L24A 4U1BA 3MATA 2BWWA 1JAWA 1QXZA 2EVOA 4FO7A 4S01A 5CDEA 4FLIA 2OAZA 2V6CA 3RORA 3S6BA 1XGMA 3CB6A 3CTZA 4HXXA 2V3YA 2Q96A 5FCFA 4FO8A 5JFRA 2NQ6A 3FM3A 2GG2A 2Q92A 3MX6A 4U6WA 1XGNA 4RGZ1 3PKCA 1M35A 2GGCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4ZNG A;  4ZWP A;  3TB5 A;  2Q95 A;  5D6F A;  2BHD A;  5D6E A;  2GU5 A;  4MAT A;  5CDL A;  1WLR A;  4FLK A;  3BIP A;  4IU6 A;  4RZZ A;  4FUK A;  1KQ0 A;  1KQ9 A;  3IU9 A;  2V3Z A;  2BH3 A;  1QZY A;  1R5H A;  1C24 A;  3RVA A;  4R60 A;  4ZWO A;  2BWX A;  3TAV A;  5E5B A;  2BWY A;  2ADU A;  1XGS A;  2BWT A;  3PKE A;  4U69 A;  2GGB A;  2BWU A;  1N51 A;  4IPA A;  4PNC A;  2GA2 A;  4U6J A;  4S2T P;  4OOK A;  1QXY A;  1W7V A;  1Y1N A;  1WY2 A;  2GU7 A;  4IF7 A;  1CHM A;  1YVM A;  3CB5 A;  1B6A A;  4FLL A;  5CLS A;  2V3X A;  1YW9 A;  2GG5 A;  2P9A A;  2Q94 A;  4U70 A;  1B59 A;  4PV4 A;  4U6Z A;  4U76 A;  2BHB A;  2BN7 A;  2OKN A;  1WKM A;  1XGO A;  1QXW A;  1C23 A;  2GG9 A;  2IW2 A;  5CNX A;  2P99 A;  3IG4 A;  4B28 A;  4IEC A;  1PV9 A;  2GG0 A;  1C21 A;  1C27 A;  2GZ5 A;  2B3K A;  2G6P A;  1WL9 A;  4U73 A;  3FMR A;  3D27 A;  1C22 A;  4FKC A;  5CDV A;  4EGE A;  1KP0 A;  4IKR A;  2P98 A;  1O0X A;  1WN1 A;  2BB7 A;  3PKB A;  3PKD A;  2GG7 A;  1R58 A;  2EVM A;  1XNZ A;  2GU4 A;  5JHU A;  2BWV A;  3IU8 A;  5CIK A;  4ZWU A;  1YW8 A;  4JUQ A;  4S2R P;  5FCH A;  3BIQ A;  3IU7 A;  1MAT A;  3L7G A;  2BHA A;  2Q93 A;  3MR1 A;  4S00 A;  2EA4 A;  2ZSG A;  4IKT A;  4KM3 A;  1WBQ A;  1W2M A;  1R5G A;  5CE6 A;  3BIT A;  4IKS A;  4U71 A;  4A6V A;  5JI6 A;  3Q6D A;  4FLJ A;  2B3L A;  1YJ3 A;  4RZY A;  1YW7 A;  2B3H A;  2DFI A;  4Z7M A;  1WL6 A;  4U6E A;  4IKU A;  3PKA A;  3FMQ A;  4U6C A;  2BHC A;  4QR8 A;  1A16 A;  1BN5 A;  2HOW A;  4IDY A;  2NQ7 A;  2GU6 A;  2GG3 A;  4U75 A;  1BOA A;  2GTX A;  2MAT A;  2GG8 A;  2EVC A;  2Q8K A;  2BWS A;  2EA2 A;  4A6W A;  3L24 A;  4U1B A;  3MAT A;  2BWW A;  1JAW A;  1QXZ A;  2EVO A;  4FO7 A;  4S01 A;  5CDE A;  4FLI A;  2OAZ A;  2V6C A;  3ROR A;  3S6B A;  1XGM A;  3CB6 A;  3CTZ A;  4HXX A;  2V3Y A;  2Q96 A;  5FCF A;  4FO8 A;  5JFR A;  2NQ6 A;  3FM3 A;  2GG2 A;  2Q92 A;  3MX6 A;  4U6W A;  1XGN A;  4RGZ 1;  3PKC A;  1M35 A;  2GGC A; 
#chains in the Genus database with same CATH topology
 4ZNG A;  4ZWP A;  3TB5 A;  2Q95 A;  5D6F A;  2BHD A;  5D6E A;  2GU5 A;  4MAT A;  5CDL A;  1WLR A;  4FLK A;  3BIP A;  4IU6 A;  4RZZ A;  4FUK A;  1KQ0 A;  1KQ9 A;  3IU9 A;  2V3Z A;  2BH3 A;  1QZY A;  1R5H A;  1C24 A;  3RVA A;  4R60 A;  4ZWO A;  2BWX A;  3TAV A;  5E5B A;  2BWY A;  2ADU A;  1XGS A;  2BWT A;  3PKE A;  4U69 A;  2GGB A;  2BWU A;  1N51 A;  4IPA A;  4PNC A;  2GA2 A;  4U6J A;  4S2T P;  4OOK A;  1QXY A;  1W7V A;  1Y1N A;  1WY2 A;  2GU7 A;  4IF7 A;  1CHM A;  1YVM A;  3CB5 A;  1B6A A;  4FLL A;  5CLS A;  2V3X A;  1YW9 A;  2GG5 A;  2P9A A;  2Q94 A;  4U70 A;  1B59 A;  4PV4 A;  4U6Z A;  4U76 A;  2BHB A;  2BN7 A;  2OKN A;  1WKM A;  1XGO A;  1QXW A;  1C23 A;  2GG9 A;  2IW2 A;  5CNX A;  2P99 A;  3IG4 A;  4B28 A;  4IEC A;  1PV9 A;  2GG0 A;  1C21 A;  1C27 A;  2GZ5 A;  2B3K A;  2G6P A;  1WL9 A;  4U73 A;  3FMR A;  3D27 A;  1C22 A;  4FKC A;  5CDV A;  4EGE A;  1KP0 A;  4IKR A;  2P98 A;  1O0X A;  1WN1 A;  2BB7 A;  3PKB A;  3PKD A;  2GG7 A;  1R58 A;  2EVM A;  1XNZ A;  2GU4 A;  5JHU A;  2BWV A;  3IU8 A;  5CIK A;  4ZWU A;  1YW8 A;  4JUQ A;  4S2R P;  5FCH A;  3BIQ A;  3IU7 A;  1MAT A;  3L7G A;  2BHA A;  2Q93 A;  3MR1 A;  4S00 A;  2EA4 A;  2ZSG A;  4IKT A;  4KM3 A;  1WBQ A;  1W2M A;  1R5G A;  5CE6 A;  3BIT A;  4IKS A;  4U71 A;  4A6V A;  5JI6 A;  3Q6D A;  4FLJ A;  2B3L A;  1YJ3 A;  4RZY A;  1YW7 A;  2B3H A;  2DFI A;  4Z7M A;  1WL6 A;  4U6E A;  4IKU A;  3PKA A;  3FMQ A;  4U6C A;  2BHC A;  4QR8 A;  1A16 A;  1BN5 A;  2HOW A;  4IDY A;  2NQ7 A;  2GU6 A;  2GG3 A;  4U75 A;  1BOA A;  2GTX A;  2MAT A;  2GG8 A;  2EVC A;  2Q8K A;  2BWS A;  2EA2 A;  4A6W A;  3L24 A;  4U1B A;  3MAT A;  2BWW A;  1JAW A;  1QXZ A;  2EVO A;  4FO7 A;  4S01 A;  5CDE A;  4FLI A;  2OAZ A;  2V6C A;  3ROR A;  3S6B A;  1XGM A;  3CB6 A;  3CTZ A;  4HXX A;  2V3Y A;  2Q96 A;  5FCF A;  4FO8 A;  5JFR A;  2NQ6 A;  3FM3 A;  2GG2 A;  2Q92 A;  3MX6 A;  4U6W A;  1XGN A;  4RGZ 1;  3PKC A;  1M35 A;  2GGC A; 
#chains in the Genus database with same CATH homology
 4ZNG A;  4ZWP A;  3TB5 A;  2Q95 A;  5D6F A;  2BHD A;  5D6E A;  2GU5 A;  4MAT A;  5CDL A;  1WLR A;  4FLK A;  3BIP A;  4IU6 A;  4RZZ A;  4FUK A;  1KQ0 A;  1KQ9 A;  3IU9 A;  2V3Z A;  2BH3 A;  1QZY A;  1R5H A;  1C24 A;  3RVA A;  4R60 A;  4ZWO A;  2BWX A;  3TAV A;  5E5B A;  2BWY A;  2ADU A;  1XGS A;  2BWT A;  3PKE A;  4U69 A;  2GGB A;  2BWU A;  1N51 A;  4IPA A;  4PNC A;  2GA2 A;  4U6J A;  4S2T P;  4OOK A;  1QXY A;  1W7V A;  1Y1N A;  1WY2 A;  2GU7 A;  4IF7 A;  1CHM A;  1YVM A;  3CB5 A;  1B6A A;  4FLL A;  5CLS A;  2V3X A;  1YW9 A;  2GG5 A;  2P9A A;  2Q94 A;  4U70 A;  1B59 A;  4PV4 A;  4U6Z A;  4U76 A;  2BHB A;  2BN7 A;  2OKN A;  1WKM A;  1XGO A;  1QXW A;  1C23 A;  2GG9 A;  2IW2 A;  5CNX A;  2P99 A;  3IG4 A;  4B28 A;  4IEC A;  1PV9 A;  2GG0 A;  1C21 A;  1C27 A;  2GZ5 A;  2B3K A;  2G6P A;  1WL9 A;  4U73 A;  3FMR A;  3D27 A;  1C22 A;  4FKC A;  5CDV A;  4EGE A;  1KP0 A;  4IKR A;  2P98 A;  1O0X A;  1WN1 A;  2BB7 A;  3PKB A;  3PKD A;  2GG7 A;  1R58 A;  2EVM A;  1XNZ A;  2GU4 A;  5JHU A;  2BWV A;  3IU8 A;  5CIK A;  4ZWU A;  1YW8 A;  4JUQ A;  4S2R P;  5FCH A;  3BIQ A;  3IU7 A;  1MAT A;  3L7G A;  2BHA A;  2Q93 A;  3MR1 A;  4S00 A;  2EA4 A;  2ZSG A;  4IKT A;  4KM3 A;  1WBQ A;  1W2M A;  1R5G A;  5CE6 A;  3BIT A;  4IKS A;  4U71 A;  4A6V A;  5JI6 A;  3Q6D A;  4FLJ A;  2B3L A;  1YJ3 A;  4RZY A;  1YW7 A;  2B3H A;  2DFI A;  4Z7M A;  1WL6 A;  4U6E A;  4IKU A;  3PKA A;  3FMQ A;  4U6C A;  2BHC A;  4QR8 A;  1A16 A;  1BN5 A;  2HOW A;  4IDY A;  2NQ7 A;  2GU6 A;  2GG3 A;  4U75 A;  1BOA A;  2GTX A;  2MAT A;  2GG8 A;  2EVC A;  2Q8K A;  2BWS A;  2EA2 A;  4A6W A;  3L24 A;  4U1B A;  3MAT A;  2BWW A;  1JAW A;  1QXZ A;  2EVO A;  4FO7 A;  4S01 A;  5CDE A;  4FLI A;  2OAZ A;  2V6C A;  3ROR A;  3S6B A;  1XGM A;  3CB6 A;  3CTZ A;  4HXX A;  2V3Y A;  2Q96 A;  5FCF A;  4FO8 A;  5JFR A;  2NQ6 A;  3FM3 A;  2GG2 A;  2Q92 A;  3MX6 A;  4U6W A;  1XGN A;  4RGZ 1;  3PKC A;  1M35 A;  2GGC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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