2EVOA

Crystal structure of methionine amino peptidase in complex with n-cyclopentyl-n-(thiazol-2-yl)oxalamide
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
260
structure length
260
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 88
structure length 260
sequence length 260
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evoA00
5CDLA 1N51A 1XGNA 1QZYA 2BWUA 2V6CA 2GGBA 4S2TP 1YW8A 1WY2A 1O0XA 2NQ6A 2NQ7A 4IU6A 2GG5A 3MATA 2Q95A 2BHBA 2ADUA 5CDEA 2BWSA 2GU7A 1KP0A 2Q94A 5E5BA 5D6EA 1WN1A 1WLRA 2BHCA 1M35A 4IKSA 3IU8A 3Q6DA 3PKAA 2G6PA 2BB7A 3S6BA 4QR8A 2EVMA 3FMQA 4U6WA 4OOKA 4A6VA 1QXYA 2GTXA 2GG7A 1YVMA 2GZ5A 3CTZA 3RVAA 2GU6A 3BITA 4JUQA 4S01A 4FLIA 4IECA 1WL6A 4U69A 4MATA 4FLJA 5D6FA 1YJ3A 2P99A 5FCFA 1R5GA 2BWTA 4FKCA 3IG4A 2DFIA 1MATA 4S2RP 3IU9A 4RZZA 5FCHA 4B28A 2EVCA 2BWYA 5JI6A 2GG9A 1XGOA 3RORA 4ZNGA 1C27A 1BN5A 4Z7MA 4FLKA 2GG0A 4PNCA 4IKUA 2P9AA 4PV4A 2EA2A 4RZYA 2BWVA 1WL9A 2Q96A 4FO8A 3L7GA 3BIPA 3IU7A 2GG2A 4U6EA 4U76A 3CB5A 1YW9A 4IF7A 4FO7A 3TB5A 4ZWOA 4IPAA 1W2MA 1YW7A 3PKBA 4EGEA 3MR1A 3BIQA 1XNZA 3PKEA 2GG8A 2BHAA 1C24A 2BH3A 1R58A 2MATA 1R5HA 1CHMA 2V3ZA 2V3YA 4R60A 1JAWA 2OAZA 2OKNA 3MX6A 3TAVA 2IW2A 1Y1NA 1C22A 1PV9A 2BN7A 4S00A 3L24A 3FM3A 1WKMA 5JFRA 1A16A 1KQ0A 2B3LA 4ZWPA 2V3XA 3FMRA 2BHDA 4U73A 1QXZA 2GA2A 2HOWA 4IKRA 4U6JA 4FUKA 2B3HA 4U70A 4ZWUA 4U1BA 1KQ9A 2GU4A 1XGMA 1QXWA 2Q93A 4IKTA 1C23A 2GG3A 2GGCA 3D27A 2EVOA 1C21A 5CE6A 1BOAA 2BWWA 1B59A 1W7VA 5CIKA 2Q8KA 2EA4A 5CDVA 2ZSGA 5CLSA 1WBQA 5JHUA 4HXXA 2P98A 4U6CA 1XGSA 2B3KA 4U71A 5CNXA 2Q92A 1B6AA 4IDYA 3PKDA 4FLLA 4KM3A 4U75A 3PKCA 4RGZ1 2BWXA 4U6ZA 2GU5A 4A6WA 3CB6A
chains in the Genus database with same CATH superfamily
5CDLA 1N51A 1XGNA 1QZYA 2BWUA 2V6CA 2GGBA 4S2TP 1YW8A 1WY2A 1O0XA 2NQ6A 2NQ7A 4IU6A 2GG5A 3MATA 2Q95A 2BHBA 2ADUA 5CDEA 2BWSA 2GU7A 1KP0A 2Q94A 5E5BA 5D6EA 1WN1A 1WLRA 2BHCA 1M35A 4IKSA 3IU8A 3Q6DA 3PKAA 2G6PA 2BB7A 3S6BA 4QR8A 2EVMA 3FMQA 4U6WA 4OOKA 4A6VA 1QXYA 2GTXA 2GG7A 1YVMA 2GZ5A 3CTZA 3RVAA 2GU6A 3BITA 4JUQA 4S01A 4FLIA 4IECA 1WL6A 4U69A 4MATA 4FLJA 5D6FA 1YJ3A 2P99A 5FCFA 1R5GA 2BWTA 4FKCA 3IG4A 2DFIA 1MATA 4S2RP 3IU9A 4RZZA 5FCHA 4B28A 2EVCA 2BWYA 5JI6A 2GG9A 1XGOA 3RORA 4ZNGA 1C27A 1BN5A 4Z7MA 4FLKA 2GG0A 4PNCA 4IKUA 2P9AA 4PV4A 2EA2A 4RZYA 2BWVA 1WL9A 2Q96A 4FO8A 3L7GA 3BIPA 3IU7A 2GG2A 4U6EA 4U76A 3CB5A 1YW9A 4IF7A 4FO7A 3TB5A 4ZWOA 4IPAA 1W2MA 1YW7A 3PKBA 4EGEA 3MR1A 3BIQA 1XNZA 3PKEA 2GG8A 2BHAA 1C24A 2BH3A 1R58A 2MATA 1R5HA 1CHMA 2V3ZA 2V3YA 4R60A 1JAWA 2OAZA 2OKNA 3MX6A 3TAVA 2IW2A 1Y1NA 1C22A 1PV9A 2BN7A 4S00A 3L24A 3FM3A 1WKMA 5JFRA 1A16A 1KQ0A 2B3LA 4ZWPA 2V3XA 3FMRA 2BHDA 4U73A 1QXZA 2GA2A 2HOWA 4IKRA 4U6JA 4FUKA 2B3HA 4U70A 4ZWUA 4U1BA 1KQ9A 2GU4A 1XGMA 1QXWA 2Q93A 4IKTA 1C23A 2GG3A 2GGCA 3D27A 2EVOA 1C21A 5CE6A 1BOAA 2BWWA 1B59A 1W7VA 5CIKA 2Q8KA 2EA4A 5CDVA 2ZSGA 5CLSA 1WBQA 5JHUA 4HXXA 2P98A 4U6CA 1XGSA 2B3KA 4U71A 5CNXA 2Q92A 1B6AA 4IDYA 3PKDA 4FLLA 4KM3A 4U75A 3PKCA 4RGZ1 2BWXA 4U6ZA 2GU5A 4A6WA 3CB6A
chains in the Genus database with same CATH topology
5CDLA 1N51A 1XGNA 1QZYA 2BWUA 2V6CA 2GGBA 4S2TP 1YW8A 1WY2A 1O0XA 2NQ6A 2NQ7A 4IU6A 2GG5A 3MATA 2Q95A 2BHBA 2ADUA 5CDEA 2BWSA 2GU7A 1KP0A 2Q94A 5E5BA 5D6EA 1WN1A 1WLRA 2BHCA 1M35A 4IKSA 3IU8A 3Q6DA 3PKAA 2G6PA 2BB7A 3S6BA 4QR8A 2EVMA 3FMQA 4U6WA 4OOKA 4A6VA 1QXYA 2GTXA 2GG7A 1YVMA 2GZ5A 3CTZA 3RVAA 2GU6A 3BITA 4JUQA 4S01A 4FLIA 4IECA 1WL6A 4U69A 4MATA 4FLJA 5D6FA 1YJ3A 2P99A 5FCFA 1R5GA 2BWTA 4FKCA 3IG4A 2DFIA 1MATA 4S2RP 3IU9A 4RZZA 5FCHA 4B28A 2EVCA 2BWYA 5JI6A 2GG9A 1XGOA 3RORA 4ZNGA 1C27A 1BN5A 4Z7MA 4FLKA 2GG0A 4PNCA 4IKUA 2P9AA 4PV4A 2EA2A 4RZYA 2BWVA 1WL9A 2Q96A 4FO8A 3L7GA 3BIPA 3IU7A 2GG2A 4U6EA 4U76A 3CB5A 1YW9A 4IF7A 4FO7A 3TB5A 4ZWOA 4IPAA 1W2MA 1YW7A 3PKBA 4EGEA 3MR1A 3BIQA 1XNZA 3PKEA 2GG8A 2BHAA 1C24A 2BH3A 1R58A 2MATA 1R5HA 1CHMA 2V3ZA 2V3YA 4R60A 1JAWA 2OAZA 2OKNA 3MX6A 3TAVA 2IW2A 1Y1NA 1C22A 1PV9A 2BN7A 4S00A 3L24A 3FM3A 1WKMA 5JFRA 1A16A 1KQ0A 2B3LA 4ZWPA 2V3XA 3FMRA 2BHDA 4U73A 1QXZA 2GA2A 2HOWA 4IKRA 4U6JA 4FUKA 2B3HA 4U70A 4ZWUA 4U1BA 1KQ9A 2GU4A 1XGMA 1QXWA 2Q93A 4IKTA 1C23A 2GG3A 2GGCA 3D27A 2EVOA 1C21A 5CE6A 1BOAA 2BWWA 1B59A 1W7VA 5CIKA 2Q8KA 2EA4A 5CDVA 2ZSGA 5CLSA 1WBQA 5JHUA 4HXXA 2P98A 4U6CA 1XGSA 2B3KA 4U71A 5CNXA 2Q92A 1B6AA 4IDYA 3PKDA 4FLLA 4KM3A 4U75A 3PKCA 4RGZ1 2BWXA 4U6ZA 2GU5A 4A6WA 3CB6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDL A;  1N51 A;  1XGN A;  1QZY A;  2BWU A;  2V6C A;  2GGB A;  4S2T P;  1YW8 A;  1WY2 A;  1O0X A;  2NQ6 A;  2NQ7 A;  4IU6 A;  2GG5 A;  3MAT A;  2Q95 A;  2BHB A;  2ADU A;  5CDE A;  2BWS A;  2GU7 A;  1KP0 A;  2Q94 A;  5E5B A;  5D6E A;  1WN1 A;  1WLR A;  2BHC A;  1M35 A;  4IKS A;  3IU8 A;  3Q6D A;  3PKA A;  2G6P A;  2BB7 A;  3S6B A;  4QR8 A;  2EVM A;  3FMQ A;  4U6W A;  4OOK A;  4A6V A;  1QXY A;  2GTX A;  2GG7 A;  1YVM A;  2GZ5 A;  3CTZ A;  3RVA A;  2GU6 A;  3BIT A;  4JUQ A;  4S01 A;  4FLI A;  4IEC A;  1WL6 A;  4U69 A;  4MAT A;  4FLJ A;  5D6F A;  1YJ3 A;  2P99 A;  5FCF A;  1R5G A;  2BWT A;  4FKC A;  3IG4 A;  2DFI A;  1MAT A;  4S2R P;  3IU9 A;  4RZZ A;  5FCH A;  4B28 A;  2EVC A;  2BWY A;  5JI6 A;  2GG9 A;  1XGO A;  3ROR A;  4ZNG A;  1C27 A;  1BN5 A;  4Z7M A;  4FLK A;  2GG0 A;  4PNC A;  4IKU A;  2P9A A;  4PV4 A;  2EA2 A;  4RZY A;  2BWV A;  1WL9 A;  2Q96 A;  4FO8 A;  3L7G A;  3BIP A;  3IU7 A;  2GG2 A;  4U6E A;  4U76 A;  3CB5 A;  1YW9 A;  4IF7 A;  4FO7 A;  3TB5 A;  4ZWO A;  4IPA A;  1W2M A;  1YW7 A;  3PKB A;  4EGE A;  3MR1 A;  3BIQ A;  1XNZ A;  3PKE A;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1R58 A;  2MAT A;  1R5H A;  1CHM A;  2V3Z A;  2V3Y A;  4R60 A;  1JAW A;  2OAZ A;  2OKN A;  3MX6 A;  3TAV A;  2IW2 A;  1Y1N A;  1C22 A;  1PV9 A;  2BN7 A;  4S00 A;  3L24 A;  3FM3 A;  1WKM A;  5JFR A;  1A16 A;  1KQ0 A;  2B3L A;  4ZWP A;  2V3X A;  3FMR A;  2BHD A;  4U73 A;  1QXZ A;  2GA2 A;  2HOW A;  4IKR A;  4U6J A;  4FUK A;  2B3H A;  4U70 A;  4ZWU A;  4U1B A;  1KQ9 A;  2GU4 A;  1XGM A;  1QXW A;  2Q93 A;  4IKT A;  1C23 A;  2GG3 A;  2GGC A;  3D27 A;  2EVO A;  1C21 A;  5CE6 A;  1BOA A;  2BWW A;  1B59 A;  1W7V A;  5CIK A;  2Q8K A;  2EA4 A;  5CDV A;  2ZSG A;  5CLS A;  1WBQ A;  5JHU A;  4HXX A;  2P98 A;  4U6C A;  1XGS A;  2B3K A;  4U71 A;  5CNX A;  2Q92 A;  1B6A A;  4IDY A;  3PKD A;  4FLL A;  4KM3 A;  4U75 A;  3PKC A;  4RGZ 1;  2BWX A;  4U6Z A;  2GU5 A;  4A6W A;  3CB6 A; 
#chains in the Genus database with same CATH topology
 5CDL A;  1N51 A;  1XGN A;  1QZY A;  2BWU A;  2V6C A;  2GGB A;  4S2T P;  1YW8 A;  1WY2 A;  1O0X A;  2NQ6 A;  2NQ7 A;  4IU6 A;  2GG5 A;  3MAT A;  2Q95 A;  2BHB A;  2ADU A;  5CDE A;  2BWS A;  2GU7 A;  1KP0 A;  2Q94 A;  5E5B A;  5D6E A;  1WN1 A;  1WLR A;  2BHC A;  1M35 A;  4IKS A;  3IU8 A;  3Q6D A;  3PKA A;  2G6P A;  2BB7 A;  3S6B A;  4QR8 A;  2EVM A;  3FMQ A;  4U6W A;  4OOK A;  4A6V A;  1QXY A;  2GTX A;  2GG7 A;  1YVM A;  2GZ5 A;  3CTZ A;  3RVA A;  2GU6 A;  3BIT A;  4JUQ A;  4S01 A;  4FLI A;  4IEC A;  1WL6 A;  4U69 A;  4MAT A;  4FLJ A;  5D6F A;  1YJ3 A;  2P99 A;  5FCF A;  1R5G A;  2BWT A;  4FKC A;  3IG4 A;  2DFI A;  1MAT A;  4S2R P;  3IU9 A;  4RZZ A;  5FCH A;  4B28 A;  2EVC A;  2BWY A;  5JI6 A;  2GG9 A;  1XGO A;  3ROR A;  4ZNG A;  1C27 A;  1BN5 A;  4Z7M A;  4FLK A;  2GG0 A;  4PNC A;  4IKU A;  2P9A A;  4PV4 A;  2EA2 A;  4RZY A;  2BWV A;  1WL9 A;  2Q96 A;  4FO8 A;  3L7G A;  3BIP A;  3IU7 A;  2GG2 A;  4U6E A;  4U76 A;  3CB5 A;  1YW9 A;  4IF7 A;  4FO7 A;  3TB5 A;  4ZWO A;  4IPA A;  1W2M A;  1YW7 A;  3PKB A;  4EGE A;  3MR1 A;  3BIQ A;  1XNZ A;  3PKE A;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1R58 A;  2MAT A;  1R5H A;  1CHM A;  2V3Z A;  2V3Y A;  4R60 A;  1JAW A;  2OAZ A;  2OKN A;  3MX6 A;  3TAV A;  2IW2 A;  1Y1N A;  1C22 A;  1PV9 A;  2BN7 A;  4S00 A;  3L24 A;  3FM3 A;  1WKM A;  5JFR A;  1A16 A;  1KQ0 A;  2B3L A;  4ZWP A;  2V3X A;  3FMR A;  2BHD A;  4U73 A;  1QXZ A;  2GA2 A;  2HOW A;  4IKR A;  4U6J A;  4FUK A;  2B3H A;  4U70 A;  4ZWU A;  4U1B A;  1KQ9 A;  2GU4 A;  1XGM A;  1QXW A;  2Q93 A;  4IKT A;  1C23 A;  2GG3 A;  2GGC A;  3D27 A;  2EVO A;  1C21 A;  5CE6 A;  1BOA A;  2BWW A;  1B59 A;  1W7V A;  5CIK A;  2Q8K A;  2EA4 A;  5CDV A;  2ZSG A;  5CLS A;  1WBQ A;  5JHU A;  4HXX A;  2P98 A;  4U6C A;  1XGS A;  2B3K A;  4U71 A;  5CNX A;  2Q92 A;  1B6A A;  4IDY A;  3PKD A;  4FLL A;  4KM3 A;  4U75 A;  3PKC A;  4RGZ 1;  2BWX A;  4U6Z A;  2GU5 A;  4A6W A;  3CB6 A; 
#chains in the Genus database with same CATH homology
 5CDL A;  1N51 A;  1XGN A;  1QZY A;  2BWU A;  2V6C A;  2GGB A;  4S2T P;  1YW8 A;  1WY2 A;  1O0X A;  2NQ6 A;  2NQ7 A;  4IU6 A;  2GG5 A;  3MAT A;  2Q95 A;  2BHB A;  2ADU A;  5CDE A;  2BWS A;  2GU7 A;  1KP0 A;  2Q94 A;  5E5B A;  5D6E A;  1WN1 A;  1WLR A;  2BHC A;  1M35 A;  4IKS A;  3IU8 A;  3Q6D A;  3PKA A;  2G6P A;  2BB7 A;  3S6B A;  4QR8 A;  2EVM A;  3FMQ A;  4U6W A;  4OOK A;  4A6V A;  1QXY A;  2GTX A;  2GG7 A;  1YVM A;  2GZ5 A;  3CTZ A;  3RVA A;  2GU6 A;  3BIT A;  4JUQ A;  4S01 A;  4FLI A;  4IEC A;  1WL6 A;  4U69 A;  4MAT A;  4FLJ A;  5D6F A;  1YJ3 A;  2P99 A;  5FCF A;  1R5G A;  2BWT A;  4FKC A;  3IG4 A;  2DFI A;  1MAT A;  4S2R P;  3IU9 A;  4RZZ A;  5FCH A;  4B28 A;  2EVC A;  2BWY A;  5JI6 A;  2GG9 A;  1XGO A;  3ROR A;  4ZNG A;  1C27 A;  1BN5 A;  4Z7M A;  4FLK A;  2GG0 A;  4PNC A;  4IKU A;  2P9A A;  4PV4 A;  2EA2 A;  4RZY A;  2BWV A;  1WL9 A;  2Q96 A;  4FO8 A;  3L7G A;  3BIP A;  3IU7 A;  2GG2 A;  4U6E A;  4U76 A;  3CB5 A;  1YW9 A;  4IF7 A;  4FO7 A;  3TB5 A;  4ZWO A;  4IPA A;  1W2M A;  1YW7 A;  3PKB A;  4EGE A;  3MR1 A;  3BIQ A;  1XNZ A;  3PKE A;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1R58 A;  2MAT A;  1R5H A;  1CHM A;  2V3Z A;  2V3Y A;  4R60 A;  1JAW A;  2OAZ A;  2OKN A;  3MX6 A;  3TAV A;  2IW2 A;  1Y1N A;  1C22 A;  1PV9 A;  2BN7 A;  4S00 A;  3L24 A;  3FM3 A;  1WKM A;  5JFR A;  1A16 A;  1KQ0 A;  2B3L A;  4ZWP A;  2V3X A;  3FMR A;  2BHD A;  4U73 A;  1QXZ A;  2GA2 A;  2HOW A;  4IKR A;  4U6J A;  4FUK A;  2B3H A;  4U70 A;  4ZWU A;  4U1B A;  1KQ9 A;  2GU4 A;  1XGM A;  1QXW A;  2Q93 A;  4IKT A;  1C23 A;  2GG3 A;  2GGC A;  3D27 A;  2EVO A;  1C21 A;  5CE6 A;  1BOA A;  2BWW A;  1B59 A;  1W7V A;  5CIK A;  2Q8K A;  2EA4 A;  5CDV A;  2ZSG A;  5CLS A;  1WBQ A;  5JHU A;  4HXX A;  2P98 A;  4U6C A;  1XGS A;  2B3K A;  4U71 A;  5CNX A;  2Q92 A;  1B6A A;  4IDY A;  3PKD A;  4FLL A;  4KM3 A;  4U75 A;  3PKC A;  4RGZ 1;  2BWX A;  4U6Z A;  2GU5 A;  4A6W A;  3CB6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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