2GG5A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 81
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg5A00
2BH3A 2NQ7A 3FM3A 3TB5A 3PKDA 2GG3A 2GU4A 4FLIA 2GG0A 2V3XA 1YW7A 4ZWOA 2GG5A 2MATA 2P98A 2GGBA 1MATA 4A6WA 5JFRA 1WBQA 3IU7A 3MR1A 3PKBA 1C27A 1R5GA 4FUKA 1W7VA 4U71A 1YJ3A 2Q92A 1R5HA 2ZSGA 2EA4A 5D6FA 4U75A 4FKCA 4MATA 4IECA 4IKUA 2DFIA 4A6VA 2B3LA 1N51A 3BIQA 4FO8A 4ZNGA 3BITA 2BHCA 4S2RP 5CLSA 2Q96A 2BWXA 4U70A 4PNCA 4S2TP 2P99A 1WLRA 3MX6A 1WN1A 3TAVA 1B6AA 4U6EA 2EVOA 4U6CA 1M35A 4IKTA 5CE6A 1YW8A 2BHBA 1PV9A 1QXYA 4RZZA 1C22A 1BN5A 4U69A 2IW2A 1BOAA 2B3HA 5D6EA 1WL9A 1KP0A 4U76A 3FMQA 2GTXA 4U73A 1KQ9A 4FLKA 4U6ZA 1JAWA 5FCFA 3D27A 2BWWA 1XGOA 5CIKA 3L24A 4S00A 4U6WA 4EGEA 1CHMA 2EVMA 3CB5A 2OKNA 3CB6A 4Z7MA 2P9AA 2GA2A 1XGMA 1Y1NA 1KQ0A 4JUQA 1A16A 1R58A 4IPAA 2BHAA 2Q8KA 4FLLA 1YVMA 2GG8A 2GG9A 1QXWA 3FMRA 4IU6A 3L7GA 1C24A 1XGNA 1C21A 1O0XA 1XGSA 2BWYA 2GGCA 1B59A 1C23A 3Q6DA 4KM3A 1WY2A 1QXZA 3RVAA 2Q94A 1WKMA 1XNZA 4HXXA 4B28A 4PV4A 4FLJA 3S6BA 3PKAA 2OAZA 2BN7A 2GG7A 2GU7A 2V3ZA 3IG4A 2BB7A 5JI6A 4IDYA 2BWUA 2HOWA 2BWVA 4IKRA 2Q93A 2V3YA 3CTZA 2ADUA 1W2MA 4R60A 2B3KA 2EA2A 2GG2A 5CDEA 3BIPA 3IU8A 2BHDA 4ZWPA 4IF7A 4S01A 5FCHA 2EVCA 5E5BA 5CDVA 2BWSA 5JHUA 2BWTA 4ZWUA 2NQ6A 4IKSA 4QR8A 5CDLA 4FO7A 4U1BA 1QZYA 4U6JA 3PKEA 3PKCA 1YW9A 2GZ5A 1WL6A 4RZYA 2GU6A 2Q95A 5CNXA 4OOKA 4RGZ1 3IU9A 2G6PA 2GU5A 2V6CA 3MATA 3RORA
chains in the Genus database with same CATH superfamily
2BH3A 2NQ7A 3FM3A 3TB5A 3PKDA 2GG3A 2GU4A 4FLIA 2GG0A 2V3XA 1YW7A 4ZWOA 2GG5A 2MATA 2P98A 2GGBA 1MATA 4A6WA 5JFRA 1WBQA 3IU7A 3MR1A 3PKBA 1C27A 1R5GA 4FUKA 1W7VA 4U71A 1YJ3A 2Q92A 1R5HA 2ZSGA 2EA4A 5D6FA 4U75A 4FKCA 4MATA 4IECA 4IKUA 2DFIA 4A6VA 2B3LA 1N51A 3BIQA 4FO8A 4ZNGA 3BITA 2BHCA 4S2RP 5CLSA 2Q96A 2BWXA 4U70A 4PNCA 4S2TP 2P99A 1WLRA 3MX6A 1WN1A 3TAVA 1B6AA 4U6EA 2EVOA 4U6CA 1M35A 4IKTA 5CE6A 1YW8A 2BHBA 1PV9A 1QXYA 4RZZA 1C22A 1BN5A 4U69A 2IW2A 1BOAA 2B3HA 5D6EA 1WL9A 1KP0A 4U76A 3FMQA 2GTXA 4U73A 1KQ9A 4FLKA 4U6ZA 1JAWA 5FCFA 3D27A 2BWWA 1XGOA 5CIKA 3L24A 4S00A 4U6WA 4EGEA 1CHMA 2EVMA 3CB5A 2OKNA 3CB6A 4Z7MA 2P9AA 2GA2A 1XGMA 1Y1NA 1KQ0A 4JUQA 1A16A 1R58A 4IPAA 2BHAA 2Q8KA 4FLLA 1YVMA 2GG8A 2GG9A 1QXWA 3FMRA 4IU6A 3L7GA 1C24A 1XGNA 1C21A 1O0XA 1XGSA 2BWYA 2GGCA 1B59A 1C23A 3Q6DA 4KM3A 1WY2A 1QXZA 3RVAA 2Q94A 1WKMA 1XNZA 4HXXA 4B28A 4PV4A 4FLJA 3S6BA 3PKAA 2OAZA 2BN7A 2GG7A 2GU7A 2V3ZA 3IG4A 2BB7A 5JI6A 4IDYA 2BWUA 2HOWA 2BWVA 4IKRA 2Q93A 2V3YA 3CTZA 2ADUA 1W2MA 4R60A 2B3KA 2EA2A 2GG2A 5CDEA 3BIPA 3IU8A 2BHDA 4ZWPA 4IF7A 4S01A 5FCHA 2EVCA 5E5BA 5CDVA 2BWSA 5JHUA 2BWTA 4ZWUA 2NQ6A 4IKSA 4QR8A 5CDLA 4FO7A 4U1BA 1QZYA 4U6JA 3PKEA 3PKCA 1YW9A 2GZ5A 1WL6A 4RZYA 2GU6A 2Q95A 5CNXA 4OOKA 4RGZ1 3IU9A 2G6PA 2GU5A 2V6CA 3MATA 3RORA
chains in the Genus database with same CATH topology
2BH3A 2NQ7A 3FM3A 3TB5A 3PKDA 2GG3A 2GU4A 4FLIA 2GG0A 2V3XA 1YW7A 4ZWOA 2GG5A 2MATA 2P98A 2GGBA 1MATA 4A6WA 5JFRA 1WBQA 3IU7A 3MR1A 3PKBA 1C27A 1R5GA 4FUKA 1W7VA 4U71A 1YJ3A 2Q92A 1R5HA 2ZSGA 2EA4A 5D6FA 4U75A 4FKCA 4MATA 4IECA 4IKUA 2DFIA 4A6VA 2B3LA 1N51A 3BIQA 4FO8A 4ZNGA 3BITA 2BHCA 4S2RP 5CLSA 2Q96A 2BWXA 4U70A 4PNCA 4S2TP 2P99A 1WLRA 3MX6A 1WN1A 3TAVA 1B6AA 4U6EA 2EVOA 4U6CA 1M35A 4IKTA 5CE6A 1YW8A 2BHBA 1PV9A 1QXYA 4RZZA 1C22A 1BN5A 4U69A 2IW2A 1BOAA 2B3HA 5D6EA 1WL9A 1KP0A 4U76A 3FMQA 2GTXA 4U73A 1KQ9A 4FLKA 4U6ZA 1JAWA 5FCFA 3D27A 2BWWA 1XGOA 5CIKA 3L24A 4S00A 4U6WA 4EGEA 1CHMA 2EVMA 3CB5A 2OKNA 3CB6A 4Z7MA 2P9AA 2GA2A 1XGMA 1Y1NA 1KQ0A 4JUQA 1A16A 1R58A 4IPAA 2BHAA 2Q8KA 4FLLA 1YVMA 2GG8A 2GG9A 1QXWA 3FMRA 4IU6A 3L7GA 1C24A 1XGNA 1C21A 1O0XA 1XGSA 2BWYA 2GGCA 1B59A 1C23A 3Q6DA 4KM3A 1WY2A 1QXZA 3RVAA 2Q94A 1WKMA 1XNZA 4HXXA 4B28A 4PV4A 4FLJA 3S6BA 3PKAA 2OAZA 2BN7A 2GG7A 2GU7A 2V3ZA 3IG4A 2BB7A 5JI6A 4IDYA 2BWUA 2HOWA 2BWVA 4IKRA 2Q93A 2V3YA 3CTZA 2ADUA 1W2MA 4R60A 2B3KA 2EA2A 2GG2A 5CDEA 3BIPA 3IU8A 2BHDA 4ZWPA 4IF7A 4S01A 5FCHA 2EVCA 5E5BA 5CDVA 2BWSA 5JHUA 2BWTA 4ZWUA 2NQ6A 4IKSA 4QR8A 5CDLA 4FO7A 4U1BA 1QZYA 4U6JA 3PKEA 3PKCA 1YW9A 2GZ5A 1WL6A 4RZYA 2GU6A 2Q95A 5CNXA 4OOKA 4RGZ1 3IU9A 2G6PA 2GU5A 2V6CA 3MATA 3RORA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BH3 A;  2NQ7 A;  3FM3 A;  3TB5 A;  3PKD A;  2GG3 A;  2GU4 A;  4FLI A;  2GG0 A;  2V3X A;  1YW7 A;  4ZWO A;  2GG5 A;  2MAT A;  2P98 A;  2GGB A;  1MAT A;  4A6W A;  5JFR A;  1WBQ A;  3IU7 A;  3MR1 A;  3PKB A;  1C27 A;  1R5G A;  4FUK A;  1W7V A;  4U71 A;  1YJ3 A;  2Q92 A;  1R5H A;  2ZSG A;  2EA4 A;  5D6F A;  4U75 A;  4FKC A;  4MAT A;  4IEC A;  4IKU A;  2DFI A;  4A6V A;  2B3L A;  1N51 A;  3BIQ A;  4FO8 A;  4ZNG A;  3BIT A;  2BHC A;  4S2R P;  5CLS A;  2Q96 A;  2BWX A;  4U70 A;  4PNC A;  4S2T P;  2P99 A;  1WLR A;  3MX6 A;  1WN1 A;  3TAV A;  1B6A A;  4U6E A;  2EVO A;  4U6C A;  1M35 A;  4IKT A;  5CE6 A;  1YW8 A;  2BHB A;  1PV9 A;  1QXY A;  4RZZ A;  1C22 A;  1BN5 A;  4U69 A;  2IW2 A;  1BOA A;  2B3H A;  5D6E A;  1WL9 A;  1KP0 A;  4U76 A;  3FMQ A;  2GTX A;  4U73 A;  1KQ9 A;  4FLK A;  4U6Z A;  1JAW A;  5FCF A;  3D27 A;  2BWW A;  1XGO A;  5CIK A;  3L24 A;  4S00 A;  4U6W A;  4EGE A;  1CHM A;  2EVM A;  3CB5 A;  2OKN A;  3CB6 A;  4Z7M A;  2P9A A;  2GA2 A;  1XGM A;  1Y1N A;  1KQ0 A;  4JUQ A;  1A16 A;  1R58 A;  4IPA A;  2BHA A;  2Q8K A;  4FLL A;  1YVM A;  2GG8 A;  2GG9 A;  1QXW A;  3FMR A;  4IU6 A;  3L7G A;  1C24 A;  1XGN A;  1C21 A;  1O0X A;  1XGS A;  2BWY A;  2GGC A;  1B59 A;  1C23 A;  3Q6D A;  4KM3 A;  1WY2 A;  1QXZ A;  3RVA A;  2Q94 A;  1WKM A;  1XNZ A;  4HXX A;  4B28 A;  4PV4 A;  4FLJ A;  3S6B A;  3PKA A;  2OAZ A;  2BN7 A;  2GG7 A;  2GU7 A;  2V3Z A;  3IG4 A;  2BB7 A;  5JI6 A;  4IDY A;  2BWU A;  2HOW A;  2BWV A;  4IKR A;  2Q93 A;  2V3Y A;  3CTZ A;  2ADU A;  1W2M A;  4R60 A;  2B3K A;  2EA2 A;  2GG2 A;  5CDE A;  3BIP A;  3IU8 A;  2BHD A;  4ZWP A;  4IF7 A;  4S01 A;  5FCH A;  2EVC A;  5E5B A;  5CDV A;  2BWS A;  5JHU A;  2BWT A;  4ZWU A;  2NQ6 A;  4IKS A;  4QR8 A;  5CDL A;  4FO7 A;  4U1B A;  1QZY A;  4U6J A;  3PKE A;  3PKC A;  1YW9 A;  2GZ5 A;  1WL6 A;  4RZY A;  2GU6 A;  2Q95 A;  5CNX A;  4OOK A;  4RGZ 1;  3IU9 A;  2G6P A;  2GU5 A;  2V6C A;  3MAT A;  3ROR A; 
#chains in the Genus database with same CATH topology
 2BH3 A;  2NQ7 A;  3FM3 A;  3TB5 A;  3PKD A;  2GG3 A;  2GU4 A;  4FLI A;  2GG0 A;  2V3X A;  1YW7 A;  4ZWO A;  2GG5 A;  2MAT A;  2P98 A;  2GGB A;  1MAT A;  4A6W A;  5JFR A;  1WBQ A;  3IU7 A;  3MR1 A;  3PKB A;  1C27 A;  1R5G A;  4FUK A;  1W7V A;  4U71 A;  1YJ3 A;  2Q92 A;  1R5H A;  2ZSG A;  2EA4 A;  5D6F A;  4U75 A;  4FKC A;  4MAT A;  4IEC A;  4IKU A;  2DFI A;  4A6V A;  2B3L A;  1N51 A;  3BIQ A;  4FO8 A;  4ZNG A;  3BIT A;  2BHC A;  4S2R P;  5CLS A;  2Q96 A;  2BWX A;  4U70 A;  4PNC A;  4S2T P;  2P99 A;  1WLR A;  3MX6 A;  1WN1 A;  3TAV A;  1B6A A;  4U6E A;  2EVO A;  4U6C A;  1M35 A;  4IKT A;  5CE6 A;  1YW8 A;  2BHB A;  1PV9 A;  1QXY A;  4RZZ A;  1C22 A;  1BN5 A;  4U69 A;  2IW2 A;  1BOA A;  2B3H A;  5D6E A;  1WL9 A;  1KP0 A;  4U76 A;  3FMQ A;  2GTX A;  4U73 A;  1KQ9 A;  4FLK A;  4U6Z A;  1JAW A;  5FCF A;  3D27 A;  2BWW A;  1XGO A;  5CIK A;  3L24 A;  4S00 A;  4U6W A;  4EGE A;  1CHM A;  2EVM A;  3CB5 A;  2OKN A;  3CB6 A;  4Z7M A;  2P9A A;  2GA2 A;  1XGM A;  1Y1N A;  1KQ0 A;  4JUQ A;  1A16 A;  1R58 A;  4IPA A;  2BHA A;  2Q8K A;  4FLL A;  1YVM A;  2GG8 A;  2GG9 A;  1QXW A;  3FMR A;  4IU6 A;  3L7G A;  1C24 A;  1XGN A;  1C21 A;  1O0X A;  1XGS A;  2BWY A;  2GGC A;  1B59 A;  1C23 A;  3Q6D A;  4KM3 A;  1WY2 A;  1QXZ A;  3RVA A;  2Q94 A;  1WKM A;  1XNZ A;  4HXX A;  4B28 A;  4PV4 A;  4FLJ A;  3S6B A;  3PKA A;  2OAZ A;  2BN7 A;  2GG7 A;  2GU7 A;  2V3Z A;  3IG4 A;  2BB7 A;  5JI6 A;  4IDY A;  2BWU A;  2HOW A;  2BWV A;  4IKR A;  2Q93 A;  2V3Y A;  3CTZ A;  2ADU A;  1W2M A;  4R60 A;  2B3K A;  2EA2 A;  2GG2 A;  5CDE A;  3BIP A;  3IU8 A;  2BHD A;  4ZWP A;  4IF7 A;  4S01 A;  5FCH A;  2EVC A;  5E5B A;  5CDV A;  2BWS A;  5JHU A;  2BWT A;  4ZWU A;  2NQ6 A;  4IKS A;  4QR8 A;  5CDL A;  4FO7 A;  4U1B A;  1QZY A;  4U6J A;  3PKE A;  3PKC A;  1YW9 A;  2GZ5 A;  1WL6 A;  4RZY A;  2GU6 A;  2Q95 A;  5CNX A;  4OOK A;  4RGZ 1;  3IU9 A;  2G6P A;  2GU5 A;  2V6C A;  3MAT A;  3ROR A; 
#chains in the Genus database with same CATH homology
 2BH3 A;  2NQ7 A;  3FM3 A;  3TB5 A;  3PKD A;  2GG3 A;  2GU4 A;  4FLI A;  2GG0 A;  2V3X A;  1YW7 A;  4ZWO A;  2GG5 A;  2MAT A;  2P98 A;  2GGB A;  1MAT A;  4A6W A;  5JFR A;  1WBQ A;  3IU7 A;  3MR1 A;  3PKB A;  1C27 A;  1R5G A;  4FUK A;  1W7V A;  4U71 A;  1YJ3 A;  2Q92 A;  1R5H A;  2ZSG A;  2EA4 A;  5D6F A;  4U75 A;  4FKC A;  4MAT A;  4IEC A;  4IKU A;  2DFI A;  4A6V A;  2B3L A;  1N51 A;  3BIQ A;  4FO8 A;  4ZNG A;  3BIT A;  2BHC A;  4S2R P;  5CLS A;  2Q96 A;  2BWX A;  4U70 A;  4PNC A;  4S2T P;  2P99 A;  1WLR A;  3MX6 A;  1WN1 A;  3TAV A;  1B6A A;  4U6E A;  2EVO A;  4U6C A;  1M35 A;  4IKT A;  5CE6 A;  1YW8 A;  2BHB A;  1PV9 A;  1QXY A;  4RZZ A;  1C22 A;  1BN5 A;  4U69 A;  2IW2 A;  1BOA A;  2B3H A;  5D6E A;  1WL9 A;  1KP0 A;  4U76 A;  3FMQ A;  2GTX A;  4U73 A;  1KQ9 A;  4FLK A;  4U6Z A;  1JAW A;  5FCF A;  3D27 A;  2BWW A;  1XGO A;  5CIK A;  3L24 A;  4S00 A;  4U6W A;  4EGE A;  1CHM A;  2EVM A;  3CB5 A;  2OKN A;  3CB6 A;  4Z7M A;  2P9A A;  2GA2 A;  1XGM A;  1Y1N A;  1KQ0 A;  4JUQ A;  1A16 A;  1R58 A;  4IPA A;  2BHA A;  2Q8K A;  4FLL A;  1YVM A;  2GG8 A;  2GG9 A;  1QXW A;  3FMR A;  4IU6 A;  3L7G A;  1C24 A;  1XGN A;  1C21 A;  1O0X A;  1XGS A;  2BWY A;  2GGC A;  1B59 A;  1C23 A;  3Q6D A;  4KM3 A;  1WY2 A;  1QXZ A;  3RVA A;  2Q94 A;  1WKM A;  1XNZ A;  4HXX A;  4B28 A;  4PV4 A;  4FLJ A;  3S6B A;  3PKA A;  2OAZ A;  2BN7 A;  2GG7 A;  2GU7 A;  2V3Z A;  3IG4 A;  2BB7 A;  5JI6 A;  4IDY A;  2BWU A;  2HOW A;  2BWV A;  4IKR A;  2Q93 A;  2V3Y A;  3CTZ A;  2ADU A;  1W2M A;  4R60 A;  2B3K A;  2EA2 A;  2GG2 A;  5CDE A;  3BIP A;  3IU8 A;  2BHD A;  4ZWP A;  4IF7 A;  4S01 A;  5FCH A;  2EVC A;  5E5B A;  5CDV A;  2BWS A;  5JHU A;  2BWT A;  4ZWU A;  2NQ6 A;  4IKS A;  4QR8 A;  5CDL A;  4FO7 A;  4U1B A;  1QZY A;  4U6J A;  3PKE A;  3PKC A;  1YW9 A;  2GZ5 A;  1WL6 A;  4RZY A;  2GU6 A;  2Q95 A;  5CNX A;  4OOK A;  4RGZ 1;  3IU9 A;  2G6P A;  2GU5 A;  2V6C A;  3MAT A;  3ROR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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