2GG7A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg7A00
2GGCA 1WL9A 1KQ0A 1WKMA 4IKUA 3L7GA 2GG7A 3IG4A 3PKEA 5FCHA 2Q92A 3FMQA 4U71A 3MATA 1QXWA 5JFRA 2GG8A 2BB7A 1KP0A 3TAVA 2V3XA 2BHAA 2ZSGA 3BITA 2GA2A 4B28A 4S00A 2BHBA 1XGSA 4IKSA 4FLLA 4IECA 2BN7A 2GZ5A 2GU6A 1R5HA 5CDVA 1WBQA 1YW9A 2DFIA 4ZWUA 5CDLA 2BWWA 4PV4A 2EA4A 2EVCA 2V3ZA 1A16A 4Z7MA 1QXZA 1C24A 2GG3A 2GU7A 3L24A 2NQ7A 2OKNA 4IKTA 4R60A 3Q6DA 2B3HA 2P98A 1M35A 1C27A 1YVMA 1B6AA 5JHUA 3FMRA 1BN5A 2GG5A 1R5GA 2B3KA 5CIKA 5D6EA 1N51A 4ZWPA 1WY2A 2GG2A 2Q95A 1QXYA 1QZYA 2EA2A 4JUQA 3FM3A 4FLKA 2MATA 2EVOA 4HXXA 3RORA 2Q94A 2GTXA 1MATA 1XNZA 1PV9A 4S01A 2EVMA 3PKDA 4U70A 4U75A 2Q93A 4FUKA 5D6FA 3TB5A 5CE6A 1WLRA 4U6JA 2B3LA 2GU5A 4FO8A 4PNCA 1R58A 5CNXA 4QR8A 4FLJA 4U76A 4FLIA 2V3YA 3CB6A 4MATA 1WL6A 3MR1A 1XGOA 2GU4A 3IU8A 1XGNA 4U73A 4RGZ1 3MX6A 3S6BA 2GGBA 1W2MA 3PKCA 3PKBA 1C23A 4IKRA 1C21A 1W7VA 4U6WA 2BWYA 4U6ZA 1YJ3A 4U69A 3RVAA 1WN1A 1XGMA 4S2TP 5CDEA 2BHDA 4FKCA 4RZZA 1Y1NA 2P9AA 2BHCA 2P99A 2BWVA 4IU6A 4KM3A 1B59A 4U1BA 3IU9A 2Q96A 1CHMA 5JI6A 1C22A 2HOWA 2BWUA 2G6PA 4OOKA 4U6CA 1YW8A 2GG9A 5CLSA 2BWXA 4S2RP 2BWSA 3D27A 2ADUA 2GG0A 3BIPA 2BWTA 2Q8KA 5E5BA 2BH3A 3IU7A 1O0XA 3CTZA 4IPAA 3BIQA 4A6WA 4ZWOA 4IF7A 1YW7A 4A6VA 4FO7A 4U6EA 2OAZA 5FCFA 1JAWA 2NQ6A 4EGEA 1BOAA 4ZNGA 2IW2A 1KQ9A 3CB5A 2V6CA 4RZYA 3PKAA 4IDYA
chains in the Genus database with same CATH superfamily
2GGCA 1WL9A 1KQ0A 1WKMA 4IKUA 3L7GA 2GG7A 3IG4A 3PKEA 5FCHA 2Q92A 3FMQA 4U71A 3MATA 1QXWA 5JFRA 2GG8A 2BB7A 1KP0A 3TAVA 2V3XA 2BHAA 2ZSGA 3BITA 2GA2A 4B28A 4S00A 2BHBA 1XGSA 4IKSA 4FLLA 4IECA 2BN7A 2GZ5A 2GU6A 1R5HA 5CDVA 1WBQA 1YW9A 2DFIA 4ZWUA 5CDLA 2BWWA 4PV4A 2EA4A 2EVCA 2V3ZA 1A16A 4Z7MA 1QXZA 1C24A 2GG3A 2GU7A 3L24A 2NQ7A 2OKNA 4IKTA 4R60A 3Q6DA 2B3HA 2P98A 1M35A 1C27A 1YVMA 1B6AA 5JHUA 3FMRA 1BN5A 2GG5A 1R5GA 2B3KA 5CIKA 5D6EA 1N51A 4ZWPA 1WY2A 2GG2A 2Q95A 1QXYA 1QZYA 2EA2A 4JUQA 3FM3A 4FLKA 2MATA 2EVOA 4HXXA 3RORA 2Q94A 2GTXA 1MATA 1XNZA 1PV9A 4S01A 2EVMA 3PKDA 4U70A 4U75A 2Q93A 4FUKA 5D6FA 3TB5A 5CE6A 1WLRA 4U6JA 2B3LA 2GU5A 4FO8A 4PNCA 1R58A 5CNXA 4QR8A 4FLJA 4U76A 4FLIA 2V3YA 3CB6A 4MATA 1WL6A 3MR1A 1XGOA 2GU4A 3IU8A 1XGNA 4U73A 4RGZ1 3MX6A 3S6BA 2GGBA 1W2MA 3PKCA 3PKBA 1C23A 4IKRA 1C21A 1W7VA 4U6WA 2BWYA 4U6ZA 1YJ3A 4U69A 3RVAA 1WN1A 1XGMA 4S2TP 5CDEA 2BHDA 4FKCA 4RZZA 1Y1NA 2P9AA 2BHCA 2P99A 2BWVA 4IU6A 4KM3A 1B59A 4U1BA 3IU9A 2Q96A 1CHMA 5JI6A 1C22A 2HOWA 2BWUA 2G6PA 4OOKA 4U6CA 1YW8A 2GG9A 5CLSA 2BWXA 4S2RP 2BWSA 3D27A 2ADUA 2GG0A 3BIPA 2BWTA 2Q8KA 5E5BA 2BH3A 3IU7A 1O0XA 3CTZA 4IPAA 3BIQA 4A6WA 4ZWOA 4IF7A 1YW7A 4A6VA 4FO7A 4U6EA 2OAZA 5FCFA 1JAWA 2NQ6A 4EGEA 1BOAA 4ZNGA 2IW2A 1KQ9A 3CB5A 2V6CA 4RZYA 3PKAA 4IDYA
chains in the Genus database with same CATH topology
2GGCA 1WL9A 1KQ0A 1WKMA 4IKUA 3L7GA 2GG7A 3IG4A 3PKEA 5FCHA 2Q92A 3FMQA 4U71A 3MATA 1QXWA 5JFRA 2GG8A 2BB7A 1KP0A 3TAVA 2V3XA 2BHAA 2ZSGA 3BITA 2GA2A 4B28A 4S00A 2BHBA 1XGSA 4IKSA 4FLLA 4IECA 2BN7A 2GZ5A 2GU6A 1R5HA 5CDVA 1WBQA 1YW9A 2DFIA 4ZWUA 5CDLA 2BWWA 4PV4A 2EA4A 2EVCA 2V3ZA 1A16A 4Z7MA 1QXZA 1C24A 2GG3A 2GU7A 3L24A 2NQ7A 2OKNA 4IKTA 4R60A 3Q6DA 2B3HA 2P98A 1M35A 1C27A 1YVMA 1B6AA 5JHUA 3FMRA 1BN5A 2GG5A 1R5GA 2B3KA 5CIKA 5D6EA 1N51A 4ZWPA 1WY2A 2GG2A 2Q95A 1QXYA 1QZYA 2EA2A 4JUQA 3FM3A 4FLKA 2MATA 2EVOA 4HXXA 3RORA 2Q94A 2GTXA 1MATA 1XNZA 1PV9A 4S01A 2EVMA 3PKDA 4U70A 4U75A 2Q93A 4FUKA 5D6FA 3TB5A 5CE6A 1WLRA 4U6JA 2B3LA 2GU5A 4FO8A 4PNCA 1R58A 5CNXA 4QR8A 4FLJA 4U76A 4FLIA 2V3YA 3CB6A 4MATA 1WL6A 3MR1A 1XGOA 2GU4A 3IU8A 1XGNA 4U73A 4RGZ1 3MX6A 3S6BA 2GGBA 1W2MA 3PKCA 3PKBA 1C23A 4IKRA 1C21A 1W7VA 4U6WA 2BWYA 4U6ZA 1YJ3A 4U69A 3RVAA 1WN1A 1XGMA 4S2TP 5CDEA 2BHDA 4FKCA 4RZZA 1Y1NA 2P9AA 2BHCA 2P99A 2BWVA 4IU6A 4KM3A 1B59A 4U1BA 3IU9A 2Q96A 1CHMA 5JI6A 1C22A 2HOWA 2BWUA 2G6PA 4OOKA 4U6CA 1YW8A 2GG9A 5CLSA 2BWXA 4S2RP 2BWSA 3D27A 2ADUA 2GG0A 3BIPA 2BWTA 2Q8KA 5E5BA 2BH3A 3IU7A 1O0XA 3CTZA 4IPAA 3BIQA 4A6WA 4ZWOA 4IF7A 1YW7A 4A6VA 4FO7A 4U6EA 2OAZA 5FCFA 1JAWA 2NQ6A 4EGEA 1BOAA 4ZNGA 2IW2A 1KQ9A 3CB5A 2V6CA 4RZYA 3PKAA 4IDYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2GGC A;  1WL9 A;  1KQ0 A;  1WKM A;  4IKU A;  3L7G A;  2GG7 A;  3IG4 A;  3PKE A;  5FCH A;  2Q92 A;  3FMQ A;  4U71 A;  3MAT A;  1QXW A;  5JFR A;  2GG8 A;  2BB7 A;  1KP0 A;  3TAV A;  2V3X A;  2BHA A;  2ZSG A;  3BIT A;  2GA2 A;  4B28 A;  4S00 A;  2BHB A;  1XGS A;  4IKS A;  4FLL A;  4IEC A;  2BN7 A;  2GZ5 A;  2GU6 A;  1R5H A;  5CDV A;  1WBQ A;  1YW9 A;  2DFI A;  4ZWU A;  5CDL A;  2BWW A;  4PV4 A;  2EA4 A;  2EVC A;  2V3Z A;  1A16 A;  4Z7M A;  1QXZ A;  1C24 A;  2GG3 A;  2GU7 A;  3L24 A;  2NQ7 A;  2OKN A;  4IKT A;  4R60 A;  3Q6D A;  2B3H A;  2P98 A;  1M35 A;  1C27 A;  1YVM A;  1B6A A;  5JHU A;  3FMR A;  1BN5 A;  2GG5 A;  1R5G A;  2B3K A;  5CIK A;  5D6E A;  1N51 A;  4ZWP A;  1WY2 A;  2GG2 A;  2Q95 A;  1QXY A;  1QZY A;  2EA2 A;  4JUQ A;  3FM3 A;  4FLK A;  2MAT A;  2EVO A;  4HXX A;  3ROR A;  2Q94 A;  2GTX A;  1MAT A;  1XNZ A;  1PV9 A;  4S01 A;  2EVM A;  3PKD A;  4U70 A;  4U75 A;  2Q93 A;  4FUK A;  5D6F A;  3TB5 A;  5CE6 A;  1WLR A;  4U6J A;  2B3L A;  2GU5 A;  4FO8 A;  4PNC A;  1R58 A;  5CNX A;  4QR8 A;  4FLJ A;  4U76 A;  4FLI A;  2V3Y A;  3CB6 A;  4MAT A;  1WL6 A;  3MR1 A;  1XGO A;  2GU4 A;  3IU8 A;  1XGN A;  4U73 A;  4RGZ 1;  3MX6 A;  3S6B A;  2GGB A;  1W2M A;  3PKC A;  3PKB A;  1C23 A;  4IKR A;  1C21 A;  1W7V A;  4U6W A;  2BWY A;  4U6Z A;  1YJ3 A;  4U69 A;  3RVA A;  1WN1 A;  1XGM A;  4S2T P;  5CDE A;  2BHD A;  4FKC A;  4RZZ A;  1Y1N A;  2P9A A;  2BHC A;  2P99 A;  2BWV A;  4IU6 A;  4KM3 A;  1B59 A;  4U1B A;  3IU9 A;  2Q96 A;  1CHM A;  5JI6 A;  1C22 A;  2HOW A;  2BWU A;  2G6P A;  4OOK A;  4U6C A;  1YW8 A;  2GG9 A;  5CLS A;  2BWX A;  4S2R P;  2BWS A;  3D27 A;  2ADU A;  2GG0 A;  3BIP A;  2BWT A;  2Q8K A;  5E5B A;  2BH3 A;  3IU7 A;  1O0X A;  3CTZ A;  4IPA A;  3BIQ A;  4A6W A;  4ZWO A;  4IF7 A;  1YW7 A;  4A6V A;  4FO7 A;  4U6E A;  2OAZ A;  5FCF A;  1JAW A;  2NQ6 A;  4EGE A;  1BOA A;  4ZNG A;  2IW2 A;  1KQ9 A;  3CB5 A;  2V6C A;  4RZY A;  3PKA A;  4IDY A; 
#chains in the Genus database with same CATH topology
 2GGC A;  1WL9 A;  1KQ0 A;  1WKM A;  4IKU A;  3L7G A;  2GG7 A;  3IG4 A;  3PKE A;  5FCH A;  2Q92 A;  3FMQ A;  4U71 A;  3MAT A;  1QXW A;  5JFR A;  2GG8 A;  2BB7 A;  1KP0 A;  3TAV A;  2V3X A;  2BHA A;  2ZSG A;  3BIT A;  2GA2 A;  4B28 A;  4S00 A;  2BHB A;  1XGS A;  4IKS A;  4FLL A;  4IEC A;  2BN7 A;  2GZ5 A;  2GU6 A;  1R5H A;  5CDV A;  1WBQ A;  1YW9 A;  2DFI A;  4ZWU A;  5CDL A;  2BWW A;  4PV4 A;  2EA4 A;  2EVC A;  2V3Z A;  1A16 A;  4Z7M A;  1QXZ A;  1C24 A;  2GG3 A;  2GU7 A;  3L24 A;  2NQ7 A;  2OKN A;  4IKT A;  4R60 A;  3Q6D A;  2B3H A;  2P98 A;  1M35 A;  1C27 A;  1YVM A;  1B6A A;  5JHU A;  3FMR A;  1BN5 A;  2GG5 A;  1R5G A;  2B3K A;  5CIK A;  5D6E A;  1N51 A;  4ZWP A;  1WY2 A;  2GG2 A;  2Q95 A;  1QXY A;  1QZY A;  2EA2 A;  4JUQ A;  3FM3 A;  4FLK A;  2MAT A;  2EVO A;  4HXX A;  3ROR A;  2Q94 A;  2GTX A;  1MAT A;  1XNZ A;  1PV9 A;  4S01 A;  2EVM A;  3PKD A;  4U70 A;  4U75 A;  2Q93 A;  4FUK A;  5D6F A;  3TB5 A;  5CE6 A;  1WLR A;  4U6J A;  2B3L A;  2GU5 A;  4FO8 A;  4PNC A;  1R58 A;  5CNX A;  4QR8 A;  4FLJ A;  4U76 A;  4FLI A;  2V3Y A;  3CB6 A;  4MAT A;  1WL6 A;  3MR1 A;  1XGO A;  2GU4 A;  3IU8 A;  1XGN A;  4U73 A;  4RGZ 1;  3MX6 A;  3S6B A;  2GGB A;  1W2M A;  3PKC A;  3PKB A;  1C23 A;  4IKR A;  1C21 A;  1W7V A;  4U6W A;  2BWY A;  4U6Z A;  1YJ3 A;  4U69 A;  3RVA A;  1WN1 A;  1XGM A;  4S2T P;  5CDE A;  2BHD A;  4FKC A;  4RZZ A;  1Y1N A;  2P9A A;  2BHC A;  2P99 A;  2BWV A;  4IU6 A;  4KM3 A;  1B59 A;  4U1B A;  3IU9 A;  2Q96 A;  1CHM A;  5JI6 A;  1C22 A;  2HOW A;  2BWU A;  2G6P A;  4OOK A;  4U6C A;  1YW8 A;  2GG9 A;  5CLS A;  2BWX A;  4S2R P;  2BWS A;  3D27 A;  2ADU A;  2GG0 A;  3BIP A;  2BWT A;  2Q8K A;  5E5B A;  2BH3 A;  3IU7 A;  1O0X A;  3CTZ A;  4IPA A;  3BIQ A;  4A6W A;  4ZWO A;  4IF7 A;  1YW7 A;  4A6V A;  4FO7 A;  4U6E A;  2OAZ A;  5FCF A;  1JAW A;  2NQ6 A;  4EGE A;  1BOA A;  4ZNG A;  2IW2 A;  1KQ9 A;  3CB5 A;  2V6C A;  4RZY A;  3PKA A;  4IDY A; 
#chains in the Genus database with same CATH homology
 2GGC A;  1WL9 A;  1KQ0 A;  1WKM A;  4IKU A;  3L7G A;  2GG7 A;  3IG4 A;  3PKE A;  5FCH A;  2Q92 A;  3FMQ A;  4U71 A;  3MAT A;  1QXW A;  5JFR A;  2GG8 A;  2BB7 A;  1KP0 A;  3TAV A;  2V3X A;  2BHA A;  2ZSG A;  3BIT A;  2GA2 A;  4B28 A;  4S00 A;  2BHB A;  1XGS A;  4IKS A;  4FLL A;  4IEC A;  2BN7 A;  2GZ5 A;  2GU6 A;  1R5H A;  5CDV A;  1WBQ A;  1YW9 A;  2DFI A;  4ZWU A;  5CDL A;  2BWW A;  4PV4 A;  2EA4 A;  2EVC A;  2V3Z A;  1A16 A;  4Z7M A;  1QXZ A;  1C24 A;  2GG3 A;  2GU7 A;  3L24 A;  2NQ7 A;  2OKN A;  4IKT A;  4R60 A;  3Q6D A;  2B3H A;  2P98 A;  1M35 A;  1C27 A;  1YVM A;  1B6A A;  5JHU A;  3FMR A;  1BN5 A;  2GG5 A;  1R5G A;  2B3K A;  5CIK A;  5D6E A;  1N51 A;  4ZWP A;  1WY2 A;  2GG2 A;  2Q95 A;  1QXY A;  1QZY A;  2EA2 A;  4JUQ A;  3FM3 A;  4FLK A;  2MAT A;  2EVO A;  4HXX A;  3ROR A;  2Q94 A;  2GTX A;  1MAT A;  1XNZ A;  1PV9 A;  4S01 A;  2EVM A;  3PKD A;  4U70 A;  4U75 A;  2Q93 A;  4FUK A;  5D6F A;  3TB5 A;  5CE6 A;  1WLR A;  4U6J A;  2B3L A;  2GU5 A;  4FO8 A;  4PNC A;  1R58 A;  5CNX A;  4QR8 A;  4FLJ A;  4U76 A;  4FLI A;  2V3Y A;  3CB6 A;  4MAT A;  1WL6 A;  3MR1 A;  1XGO A;  2GU4 A;  3IU8 A;  1XGN A;  4U73 A;  4RGZ 1;  3MX6 A;  3S6B A;  2GGB A;  1W2M A;  3PKC A;  3PKB A;  1C23 A;  4IKR A;  1C21 A;  1W7V A;  4U6W A;  2BWY A;  4U6Z A;  1YJ3 A;  4U69 A;  3RVA A;  1WN1 A;  1XGM A;  4S2T P;  5CDE A;  2BHD A;  4FKC A;  4RZZ A;  1Y1N A;  2P9A A;  2BHC A;  2P99 A;  2BWV A;  4IU6 A;  4KM3 A;  1B59 A;  4U1B A;  3IU9 A;  2Q96 A;  1CHM A;  5JI6 A;  1C22 A;  2HOW A;  2BWU A;  2G6P A;  4OOK A;  4U6C A;  1YW8 A;  2GG9 A;  5CLS A;  2BWX A;  4S2R P;  2BWS A;  3D27 A;  2ADU A;  2GG0 A;  3BIP A;  2BWT A;  2Q8K A;  5E5B A;  2BH3 A;  3IU7 A;  1O0X A;  3CTZ A;  4IPA A;  3BIQ A;  4A6W A;  4ZWO A;  4IF7 A;  1YW7 A;  4A6V A;  4FO7 A;  4U6E A;  2OAZ A;  5FCF A;  1JAW A;  2NQ6 A;  4EGE A;  1BOA A;  4ZNG A;  2IW2 A;  1KQ9 A;  3CB5 A;  2V6C A;  4RZY A;  3PKA A;  4IDY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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