2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
5CDLA 4OOKA 5JI6A 4IECA 4U6ZA 5CLSA 2BH3A 2MATA 2BWWA 2BWYA 1KQ0A 1WKMA 2V3YA 3CTZA 4FLLA 4S01A 4U6JA 4U75A 5FCHA 2Q96A 2BB7A 2OKNA 1R5GA 2GG8A 1YW8A 1Y1NA 3PKAA 4FLJA 2BHBA 1QXWA 2BWUA 4A6WA 3MX6A 1B6AA 1R58A 1MATA 2ADUA 2GU5A 4S2RP 4U71A 2P98A 2GG3A 4RZYA 1C24A 1XGOA 2GGCA 2G6PA 2Q92A 3RORA 2V3XA 1O0XA 5CDVA 4IU6A 4ZWOA 2EVOA 4U6EA 4U73A 3FM3A 3IU7A 3PKCA 1KQ9A 4FO8A 3L7GA 4IPAA 4A6VA 3BIQA 1WLRA 3FMQA 4S00A 1QZYA 4B28A 3S6BA 3IU8A 4U1BA 5E5BA 1M35A 2GA2A 1WN1A 1BOAA 2GG2A 3MR1A 2B3KA 2BWXA 2EVCA 2GG9A 3CB6A 3BIPA 3PKEA 4R60A 5D6FA 5FCFA 2B3HA 2Q93A 2EA4A 4JUQA 1QXYA 2V6CA 3TB5A 4U6CA 1YJ3A 4IF7A 2Q95A 4U70A 1C27A 1XGSA 1YW7A 3L24A 1A16A 2IW2A 2NQ7A 3IU9A 4MATA 2GTXA 1C22A 5JFRA 1XGNA 4EGEA 2NQ6A 2Q8KA 5D6EA 3MATA 2Q94A 2B3LA 1WL6A 1B59A 4IKUA 3PKDA 4QR8A 4IKSA 4PNCA 4IKRA 4S2TP 1BN5A 2BHAA 3CB5A 4PV4A 4U69A 1YVMA 5CNXA 2OAZA 2BWSA 4KM3A 1PV9A 3D27A 3IG4A 4ZNGA 1WY2A 2GU7A 4IDYA 2P99A 4FO7A 4RGZ1 5CE6A 1YW9A 5JHUA 3BITA 4FKCA 2BHCA 2GGBA 2BN7A 1W7VA 1JAWA 2P9AA 1C21A 2GG0A 3Q6DA 2GU4A 4U76A 4IKTA 1WL9A 4FLKA 4Z7MA 1N51A 2GZ5A 2DFIA 3FMRA 1R5HA 4ZWUA 1KP0A 1W2MA 3PKBA 2GU6A 3RVAA 2EVMA 4FUKA 2BHDA 1C23A 2HOWA 5CDEA 4HXXA 1XGMA 2GG7A 2ZSGA 2V3ZA 1CHMA 3TAVA 5CIKA 4RZZA 4FLIA 4U6WA 2GG5A 1QXZA 2BWVA 2BWTA 2EA2A 4ZWPA 1WBQA 1XNZA
chains in the Genus database with same CATH superfamily
5CDLA 4OOKA 5JI6A 4IECA 4U6ZA 5CLSA 2BH3A 2MATA 2BWWA 2BWYA 1KQ0A 1WKMA 2V3YA 3CTZA 4FLLA 4S01A 4U6JA 4U75A 5FCHA 2Q96A 2BB7A 2OKNA 1R5GA 2GG8A 1YW8A 1Y1NA 3PKAA 4FLJA 2BHBA 1QXWA 2BWUA 4A6WA 3MX6A 1B6AA 1R58A 1MATA 2ADUA 2GU5A 4S2RP 4U71A 2P98A 2GG3A 4RZYA 1C24A 1XGOA 2GGCA 2G6PA 2Q92A 3RORA 2V3XA 1O0XA 5CDVA 4IU6A 4ZWOA 2EVOA 4U6EA 4U73A 3FM3A 3IU7A 3PKCA 1KQ9A 4FO8A 3L7GA 4IPAA 4A6VA 3BIQA 1WLRA 3FMQA 4S00A 1QZYA 4B28A 3S6BA 3IU8A 4U1BA 5E5BA 1M35A 2GA2A 1WN1A 1BOAA 2GG2A 3MR1A 2B3KA 2BWXA 2EVCA 2GG9A 3CB6A 3BIPA 3PKEA 4R60A 5D6FA 5FCFA 2B3HA 2Q93A 2EA4A 4JUQA 1QXYA 2V6CA 3TB5A 4U6CA 1YJ3A 4IF7A 2Q95A 4U70A 1C27A 1XGSA 1YW7A 3L24A 1A16A 2IW2A 2NQ7A 3IU9A 4MATA 2GTXA 1C22A 5JFRA 1XGNA 4EGEA 2NQ6A 2Q8KA 5D6EA 3MATA 2Q94A 2B3LA 1WL6A 1B59A 4IKUA 3PKDA 4QR8A 4IKSA 4PNCA 4IKRA 4S2TP 1BN5A 2BHAA 3CB5A 4PV4A 4U69A 1YVMA 5CNXA 2OAZA 2BWSA 4KM3A 1PV9A 3D27A 3IG4A 4ZNGA 1WY2A 2GU7A 4IDYA 2P99A 4FO7A 4RGZ1 5CE6A 1YW9A 5JHUA 3BITA 4FKCA 2BHCA 2GGBA 2BN7A 1W7VA 1JAWA 2P9AA 1C21A 2GG0A 3Q6DA 2GU4A 4U76A 4IKTA 1WL9A 4FLKA 4Z7MA 1N51A 2GZ5A 2DFIA 3FMRA 1R5HA 4ZWUA 1KP0A 1W2MA 3PKBA 2GU6A 3RVAA 2EVMA 4FUKA 2BHDA 1C23A 2HOWA 5CDEA 4HXXA 1XGMA 2GG7A 2ZSGA 2V3ZA 1CHMA 3TAVA 5CIKA 4RZZA 4FLIA 4U6WA 2GG5A 1QXZA 2BWVA 2BWTA 2EA2A 4ZWPA 1WBQA 1XNZA
chains in the Genus database with same CATH topology
5CDLA 4OOKA 5JI6A 4IECA 4U6ZA 5CLSA 2BH3A 2MATA 2BWWA 2BWYA 1KQ0A 1WKMA 2V3YA 3CTZA 4FLLA 4S01A 4U6JA 4U75A 5FCHA 2Q96A 2BB7A 2OKNA 1R5GA 2GG8A 1YW8A 1Y1NA 3PKAA 4FLJA 2BHBA 1QXWA 2BWUA 4A6WA 3MX6A 1B6AA 1R58A 1MATA 2ADUA 2GU5A 4S2RP 4U71A 2P98A 2GG3A 4RZYA 1C24A 1XGOA 2GGCA 2G6PA 2Q92A 3RORA 2V3XA 1O0XA 5CDVA 4IU6A 4ZWOA 2EVOA 4U6EA 4U73A 3FM3A 3IU7A 3PKCA 1KQ9A 4FO8A 3L7GA 4IPAA 4A6VA 3BIQA 1WLRA 3FMQA 4S00A 1QZYA 4B28A 3S6BA 3IU8A 4U1BA 5E5BA 1M35A 2GA2A 1WN1A 1BOAA 2GG2A 3MR1A 2B3KA 2BWXA 2EVCA 2GG9A 3CB6A 3BIPA 3PKEA 4R60A 5D6FA 5FCFA 2B3HA 2Q93A 2EA4A 4JUQA 1QXYA 2V6CA 3TB5A 4U6CA 1YJ3A 4IF7A 2Q95A 4U70A 1C27A 1XGSA 1YW7A 3L24A 1A16A 2IW2A 2NQ7A 3IU9A 4MATA 2GTXA 1C22A 5JFRA 1XGNA 4EGEA 2NQ6A 2Q8KA 5D6EA 3MATA 2Q94A 2B3LA 1WL6A 1B59A 4IKUA 3PKDA 4QR8A 4IKSA 4PNCA 4IKRA 4S2TP 1BN5A 2BHAA 3CB5A 4PV4A 4U69A 1YVMA 5CNXA 2OAZA 2BWSA 4KM3A 1PV9A 3D27A 3IG4A 4ZNGA 1WY2A 2GU7A 4IDYA 2P99A 4FO7A 4RGZ1 5CE6A 1YW9A 5JHUA 3BITA 4FKCA 2BHCA 2GGBA 2BN7A 1W7VA 1JAWA 2P9AA 1C21A 2GG0A 3Q6DA 2GU4A 4U76A 4IKTA 1WL9A 4FLKA 4Z7MA 1N51A 2GZ5A 2DFIA 3FMRA 1R5HA 4ZWUA 1KP0A 1W2MA 3PKBA 2GU6A 3RVAA 2EVMA 4FUKA 2BHDA 1C23A 2HOWA 5CDEA 4HXXA 1XGMA 2GG7A 2ZSGA 2V3ZA 1CHMA 3TAVA 5CIKA 4RZZA 4FLIA 4U6WA 2GG5A 1QXZA 2BWVA 2BWTA 2EA2A 4ZWPA 1WBQA 1XNZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDL A;  4OOK A;  5JI6 A;  4IEC A;  4U6Z A;  5CLS A;  2BH3 A;  2MAT A;  2BWW A;  2BWY A;  1KQ0 A;  1WKM A;  2V3Y A;  3CTZ A;  4FLL A;  4S01 A;  4U6J A;  4U75 A;  5FCH A;  2Q96 A;  2BB7 A;  2OKN A;  1R5G A;  2GG8 A;  1YW8 A;  1Y1N A;  3PKA A;  4FLJ A;  2BHB A;  1QXW A;  2BWU A;  4A6W A;  3MX6 A;  1B6A A;  1R58 A;  1MAT A;  2ADU A;  2GU5 A;  4S2R P;  4U71 A;  2P98 A;  2GG3 A;  4RZY A;  1C24 A;  1XGO A;  2GGC A;  2G6P A;  2Q92 A;  3ROR A;  2V3X A;  1O0X A;  5CDV A;  4IU6 A;  4ZWO A;  2EVO A;  4U6E A;  4U73 A;  3FM3 A;  3IU7 A;  3PKC A;  1KQ9 A;  4FO8 A;  3L7G A;  4IPA A;  4A6V A;  3BIQ A;  1WLR A;  3FMQ A;  4S00 A;  1QZY A;  4B28 A;  3S6B A;  3IU8 A;  4U1B A;  5E5B A;  1M35 A;  2GA2 A;  1WN1 A;  1BOA A;  2GG2 A;  3MR1 A;  2B3K A;  2BWX A;  2EVC A;  2GG9 A;  3CB6 A;  3BIP A;  3PKE A;  4R60 A;  5D6F A;  5FCF A;  2B3H A;  2Q93 A;  2EA4 A;  4JUQ A;  1QXY A;  2V6C A;  3TB5 A;  4U6C A;  1YJ3 A;  4IF7 A;  2Q95 A;  4U70 A;  1C27 A;  1XGS A;  1YW7 A;  3L24 A;  1A16 A;  2IW2 A;  2NQ7 A;  3IU9 A;  4MAT A;  2GTX A;  1C22 A;  5JFR A;  1XGN A;  4EGE A;  2NQ6 A;  2Q8K A;  5D6E A;  3MAT A;  2Q94 A;  2B3L A;  1WL6 A;  1B59 A;  4IKU A;  3PKD A;  4QR8 A;  4IKS A;  4PNC A;  4IKR A;  4S2T P;  1BN5 A;  2BHA A;  3CB5 A;  4PV4 A;  4U69 A;  1YVM A;  5CNX A;  2OAZ A;  2BWS A;  4KM3 A;  1PV9 A;  3D27 A;  3IG4 A;  4ZNG A;  1WY2 A;  2GU7 A;  4IDY A;  2P99 A;  4FO7 A;  4RGZ 1;  5CE6 A;  1YW9 A;  5JHU A;  3BIT A;  4FKC A;  2BHC A;  2GGB A;  2BN7 A;  1W7V A;  1JAW A;  2P9A A;  1C21 A;  2GG0 A;  3Q6D A;  2GU4 A;  4U76 A;  4IKT A;  1WL9 A;  4FLK A;  4Z7M A;  1N51 A;  2GZ5 A;  2DFI A;  3FMR A;  1R5H A;  4ZWU A;  1KP0 A;  1W2M A;  3PKB A;  2GU6 A;  3RVA A;  2EVM A;  4FUK A;  2BHD A;  1C23 A;  2HOW A;  5CDE A;  4HXX A;  1XGM A;  2GG7 A;  2ZSG A;  2V3Z A;  1CHM A;  3TAV A;  5CIK A;  4RZZ A;  4FLI A;  4U6W A;  2GG5 A;  1QXZ A;  2BWV A;  2BWT A;  2EA2 A;  4ZWP A;  1WBQ A;  1XNZ A; 
#chains in the Genus database with same CATH topology
 5CDL A;  4OOK A;  5JI6 A;  4IEC A;  4U6Z A;  5CLS A;  2BH3 A;  2MAT A;  2BWW A;  2BWY A;  1KQ0 A;  1WKM A;  2V3Y A;  3CTZ A;  4FLL A;  4S01 A;  4U6J A;  4U75 A;  5FCH A;  2Q96 A;  2BB7 A;  2OKN A;  1R5G A;  2GG8 A;  1YW8 A;  1Y1N A;  3PKA A;  4FLJ A;  2BHB A;  1QXW A;  2BWU A;  4A6W A;  3MX6 A;  1B6A A;  1R58 A;  1MAT A;  2ADU A;  2GU5 A;  4S2R P;  4U71 A;  2P98 A;  2GG3 A;  4RZY A;  1C24 A;  1XGO A;  2GGC A;  2G6P A;  2Q92 A;  3ROR A;  2V3X A;  1O0X A;  5CDV A;  4IU6 A;  4ZWO A;  2EVO A;  4U6E A;  4U73 A;  3FM3 A;  3IU7 A;  3PKC A;  1KQ9 A;  4FO8 A;  3L7G A;  4IPA A;  4A6V A;  3BIQ A;  1WLR A;  3FMQ A;  4S00 A;  1QZY A;  4B28 A;  3S6B A;  3IU8 A;  4U1B A;  5E5B A;  1M35 A;  2GA2 A;  1WN1 A;  1BOA A;  2GG2 A;  3MR1 A;  2B3K A;  2BWX A;  2EVC A;  2GG9 A;  3CB6 A;  3BIP A;  3PKE A;  4R60 A;  5D6F A;  5FCF A;  2B3H A;  2Q93 A;  2EA4 A;  4JUQ A;  1QXY A;  2V6C A;  3TB5 A;  4U6C A;  1YJ3 A;  4IF7 A;  2Q95 A;  4U70 A;  1C27 A;  1XGS A;  1YW7 A;  3L24 A;  1A16 A;  2IW2 A;  2NQ7 A;  3IU9 A;  4MAT A;  2GTX A;  1C22 A;  5JFR A;  1XGN A;  4EGE A;  2NQ6 A;  2Q8K A;  5D6E A;  3MAT A;  2Q94 A;  2B3L A;  1WL6 A;  1B59 A;  4IKU A;  3PKD A;  4QR8 A;  4IKS A;  4PNC A;  4IKR A;  4S2T P;  1BN5 A;  2BHA A;  3CB5 A;  4PV4 A;  4U69 A;  1YVM A;  5CNX A;  2OAZ A;  2BWS A;  4KM3 A;  1PV9 A;  3D27 A;  3IG4 A;  4ZNG A;  1WY2 A;  2GU7 A;  4IDY A;  2P99 A;  4FO7 A;  4RGZ 1;  5CE6 A;  1YW9 A;  5JHU A;  3BIT A;  4FKC A;  2BHC A;  2GGB A;  2BN7 A;  1W7V A;  1JAW A;  2P9A A;  1C21 A;  2GG0 A;  3Q6D A;  2GU4 A;  4U76 A;  4IKT A;  1WL9 A;  4FLK A;  4Z7M A;  1N51 A;  2GZ5 A;  2DFI A;  3FMR A;  1R5H A;  4ZWU A;  1KP0 A;  1W2M A;  3PKB A;  2GU6 A;  3RVA A;  2EVM A;  4FUK A;  2BHD A;  1C23 A;  2HOW A;  5CDE A;  4HXX A;  1XGM A;  2GG7 A;  2ZSG A;  2V3Z A;  1CHM A;  3TAV A;  5CIK A;  4RZZ A;  4FLI A;  4U6W A;  2GG5 A;  1QXZ A;  2BWV A;  2BWT A;  2EA2 A;  4ZWP A;  1WBQ A;  1XNZ A; 
#chains in the Genus database with same CATH homology
 5CDL A;  4OOK A;  5JI6 A;  4IEC A;  4U6Z A;  5CLS A;  2BH3 A;  2MAT A;  2BWW A;  2BWY A;  1KQ0 A;  1WKM A;  2V3Y A;  3CTZ A;  4FLL A;  4S01 A;  4U6J A;  4U75 A;  5FCH A;  2Q96 A;  2BB7 A;  2OKN A;  1R5G A;  2GG8 A;  1YW8 A;  1Y1N A;  3PKA A;  4FLJ A;  2BHB A;  1QXW A;  2BWU A;  4A6W A;  3MX6 A;  1B6A A;  1R58 A;  1MAT A;  2ADU A;  2GU5 A;  4S2R P;  4U71 A;  2P98 A;  2GG3 A;  4RZY A;  1C24 A;  1XGO A;  2GGC A;  2G6P A;  2Q92 A;  3ROR A;  2V3X A;  1O0X A;  5CDV A;  4IU6 A;  4ZWO A;  2EVO A;  4U6E A;  4U73 A;  3FM3 A;  3IU7 A;  3PKC A;  1KQ9 A;  4FO8 A;  3L7G A;  4IPA A;  4A6V A;  3BIQ A;  1WLR A;  3FMQ A;  4S00 A;  1QZY A;  4B28 A;  3S6B A;  3IU8 A;  4U1B A;  5E5B A;  1M35 A;  2GA2 A;  1WN1 A;  1BOA A;  2GG2 A;  3MR1 A;  2B3K A;  2BWX A;  2EVC A;  2GG9 A;  3CB6 A;  3BIP A;  3PKE A;  4R60 A;  5D6F A;  5FCF A;  2B3H A;  2Q93 A;  2EA4 A;  4JUQ A;  1QXY A;  2V6C A;  3TB5 A;  4U6C A;  1YJ3 A;  4IF7 A;  2Q95 A;  4U70 A;  1C27 A;  1XGS A;  1YW7 A;  3L24 A;  1A16 A;  2IW2 A;  2NQ7 A;  3IU9 A;  4MAT A;  2GTX A;  1C22 A;  5JFR A;  1XGN A;  4EGE A;  2NQ6 A;  2Q8K A;  5D6E A;  3MAT A;  2Q94 A;  2B3L A;  1WL6 A;  1B59 A;  4IKU A;  3PKD A;  4QR8 A;  4IKS A;  4PNC A;  4IKR A;  4S2T P;  1BN5 A;  2BHA A;  3CB5 A;  4PV4 A;  4U69 A;  1YVM A;  5CNX A;  2OAZ A;  2BWS A;  4KM3 A;  1PV9 A;  3D27 A;  3IG4 A;  4ZNG A;  1WY2 A;  2GU7 A;  4IDY A;  2P99 A;  4FO7 A;  4RGZ 1;  5CE6 A;  1YW9 A;  5JHU A;  3BIT A;  4FKC A;  2BHC A;  2GGB A;  2BN7 A;  1W7V A;  1JAW A;  2P9A A;  1C21 A;  2GG0 A;  3Q6D A;  2GU4 A;  4U76 A;  4IKT A;  1WL9 A;  4FLK A;  4Z7M A;  1N51 A;  2GZ5 A;  2DFI A;  3FMR A;  1R5H A;  4ZWU A;  1KP0 A;  1W2M A;  3PKB A;  2GU6 A;  3RVA A;  2EVM A;  4FUK A;  2BHD A;  1C23 A;  2HOW A;  5CDE A;  4HXX A;  1XGM A;  2GG7 A;  2ZSG A;  2V3Z A;  1CHM A;  3TAV A;  5CIK A;  4RZZ A;  4FLI A;  4U6W A;  2GG5 A;  1QXZ A;  2BWV A;  2BWT A;  2EA2 A;  4ZWP A;  1WBQ A;  1XNZ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...