2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
2Q93A 2BHCA 5D6FA 3MX6A 4S01A 2ZSGA 3MATA 2GG7A 2MATA 4QR8A 4HXXA 2BN7A 1W2MA 3FMRA 2GG2A 3BIPA 3PKAA 4FUKA 5D6EA 1KQ0A 1QXWA 4IKSA 5CDLA 4OOKA 1O0XA 3FMQA 3RVAA 1C27A 2V3YA 2ADUA 1WBQA 2BHAA 4S00A 3PKDA 1PV9A 2GU7A 4FO8A 4IECA 5CIKA 2GG3A 2IW2A 2P98A 3IG4A 3IU7A 4FLKA 2V3ZA 3RORA 2Q94A 1WN1A 2GZ5A 4U6CA 1N51A 4FLIA 2GG0A 2V6CA 2BB7A 2GGBA 4U6EA 3BITA 3IU8A 3TB5A 4ZWUA 5CLSA 4Z7MA 2BWUA 3L24A 1YW7A 5JI6A 2GU6A 2GU4A 4U76A 3BIQA 1B6AA 3PKCA 2EVCA 2BH3A 1Y1NA 4U69A 4ZNGA 1KQ9A 4B28A 1R58A 1M35A 3TAVA 1C22A 2G6PA 1XGOA 5E5BA 1XGSA 2EVOA 4IKUA 2OAZA 4A6VA 1WLRA 4MATA 4FKCA 2NQ7A 4FO7A 4RGZ1 2NQ6A 2EA2A 2BWWA 4ZWOA 2HOWA 4IF7A 2BHDA 2BWTA 2GU5A 3S6BA 2BHBA 5FCFA 2B3HA 4U6WA 1WKMA 2P99A 1R5HA 4U71A 1QZYA 3CB6A 1MATA 4S2RP 4U70A 2GG8A 4IPAA 2Q96A 4IU6A 2EA4A 1XGNA 1C24A 2B3KA 2P9AA 2BWYA 4FLLA 1WL9A 4U73A 5JFRA 3CTZA 5FCHA 1C23A 3D27A 2B3LA 3PKEA 3Q6DA 2BWXA 3FM3A 2Q95A 4EGEA 2BWSA 1QXYA 3L7GA 5CNXA 4JUQA 3CB5A 4IKRA 1XNZA 2GA2A 2GGCA 1B59A 4RZYA 2EVMA 2Q8KA 2GTXA 4ZWPA 1BN5A 1BOAA 1YVMA 4IKTA 1WY2A 1C21A 4S2TP 5CDEA 5JHUA 1QXZA 4RZZA 4U75A 1A16A 5CDVA 2BWVA 4A6WA 2OKNA 1CHMA 2V3XA 4R60A 3PKBA 4IDYA 2DFIA 2Q92A 1KP0A 4PNCA 4U6JA 1XGMA 3MR1A 4U1BA 1YW9A 4U6ZA 1R5GA 4PV4A 1YJ3A 2GG5A 1JAWA 4KM3A 2GG9A 3IU9A 1W7VA 4FLJA 1YW8A 1WL6A 5CE6A
chains in the Genus database with same CATH superfamily
2Q93A 2BHCA 5D6FA 3MX6A 4S01A 2ZSGA 3MATA 2GG7A 2MATA 4QR8A 4HXXA 2BN7A 1W2MA 3FMRA 2GG2A 3BIPA 3PKAA 4FUKA 5D6EA 1KQ0A 1QXWA 4IKSA 5CDLA 4OOKA 1O0XA 3FMQA 3RVAA 1C27A 2V3YA 2ADUA 1WBQA 2BHAA 4S00A 3PKDA 1PV9A 2GU7A 4FO8A 4IECA 5CIKA 2GG3A 2IW2A 2P98A 3IG4A 3IU7A 4FLKA 2V3ZA 3RORA 2Q94A 1WN1A 2GZ5A 4U6CA 1N51A 4FLIA 2GG0A 2V6CA 2BB7A 2GGBA 4U6EA 3BITA 3IU8A 3TB5A 4ZWUA 5CLSA 4Z7MA 2BWUA 3L24A 1YW7A 5JI6A 2GU6A 2GU4A 4U76A 3BIQA 1B6AA 3PKCA 2EVCA 2BH3A 1Y1NA 4U69A 4ZNGA 1KQ9A 4B28A 1R58A 1M35A 3TAVA 1C22A 2G6PA 1XGOA 5E5BA 1XGSA 2EVOA 4IKUA 2OAZA 4A6VA 1WLRA 4MATA 4FKCA 2NQ7A 4FO7A 4RGZ1 2NQ6A 2EA2A 2BWWA 4ZWOA 2HOWA 4IF7A 2BHDA 2BWTA 2GU5A 3S6BA 2BHBA 5FCFA 2B3HA 4U6WA 1WKMA 2P99A 1R5HA 4U71A 1QZYA 3CB6A 1MATA 4S2RP 4U70A 2GG8A 4IPAA 2Q96A 4IU6A 2EA4A 1XGNA 1C24A 2B3KA 2P9AA 2BWYA 4FLLA 1WL9A 4U73A 5JFRA 3CTZA 5FCHA 1C23A 3D27A 2B3LA 3PKEA 3Q6DA 2BWXA 3FM3A 2Q95A 4EGEA 2BWSA 1QXYA 3L7GA 5CNXA 4JUQA 3CB5A 4IKRA 1XNZA 2GA2A 2GGCA 1B59A 4RZYA 2EVMA 2Q8KA 2GTXA 4ZWPA 1BN5A 1BOAA 1YVMA 4IKTA 1WY2A 1C21A 4S2TP 5CDEA 5JHUA 1QXZA 4RZZA 4U75A 1A16A 5CDVA 2BWVA 4A6WA 2OKNA 1CHMA 2V3XA 4R60A 3PKBA 4IDYA 2DFIA 2Q92A 1KP0A 4PNCA 4U6JA 1XGMA 3MR1A 4U1BA 1YW9A 4U6ZA 1R5GA 4PV4A 1YJ3A 2GG5A 1JAWA 4KM3A 2GG9A 3IU9A 1W7VA 4FLJA 1YW8A 1WL6A 5CE6A
chains in the Genus database with same CATH topology
2Q93A 2BHCA 5D6FA 3MX6A 4S01A 2ZSGA 3MATA 2GG7A 2MATA 4QR8A 4HXXA 2BN7A 1W2MA 3FMRA 2GG2A 3BIPA 3PKAA 4FUKA 5D6EA 1KQ0A 1QXWA 4IKSA 5CDLA 4OOKA 1O0XA 3FMQA 3RVAA 1C27A 2V3YA 2ADUA 1WBQA 2BHAA 4S00A 3PKDA 1PV9A 2GU7A 4FO8A 4IECA 5CIKA 2GG3A 2IW2A 2P98A 3IG4A 3IU7A 4FLKA 2V3ZA 3RORA 2Q94A 1WN1A 2GZ5A 4U6CA 1N51A 4FLIA 2GG0A 2V6CA 2BB7A 2GGBA 4U6EA 3BITA 3IU8A 3TB5A 4ZWUA 5CLSA 4Z7MA 2BWUA 3L24A 1YW7A 5JI6A 2GU6A 2GU4A 4U76A 3BIQA 1B6AA 3PKCA 2EVCA 2BH3A 1Y1NA 4U69A 4ZNGA 1KQ9A 4B28A 1R58A 1M35A 3TAVA 1C22A 2G6PA 1XGOA 5E5BA 1XGSA 2EVOA 4IKUA 2OAZA 4A6VA 1WLRA 4MATA 4FKCA 2NQ7A 4FO7A 4RGZ1 2NQ6A 2EA2A 2BWWA 4ZWOA 2HOWA 4IF7A 2BHDA 2BWTA 2GU5A 3S6BA 2BHBA 5FCFA 2B3HA 4U6WA 1WKMA 2P99A 1R5HA 4U71A 1QZYA 3CB6A 1MATA 4S2RP 4U70A 2GG8A 4IPAA 2Q96A 4IU6A 2EA4A 1XGNA 1C24A 2B3KA 2P9AA 2BWYA 4FLLA 1WL9A 4U73A 5JFRA 3CTZA 5FCHA 1C23A 3D27A 2B3LA 3PKEA 3Q6DA 2BWXA 3FM3A 2Q95A 4EGEA 2BWSA 1QXYA 3L7GA 5CNXA 4JUQA 3CB5A 4IKRA 1XNZA 2GA2A 2GGCA 1B59A 4RZYA 2EVMA 2Q8KA 2GTXA 4ZWPA 1BN5A 1BOAA 1YVMA 4IKTA 1WY2A 1C21A 4S2TP 5CDEA 5JHUA 1QXZA 4RZZA 4U75A 1A16A 5CDVA 2BWVA 4A6WA 2OKNA 1CHMA 2V3XA 4R60A 3PKBA 4IDYA 2DFIA 2Q92A 1KP0A 4PNCA 4U6JA 1XGMA 3MR1A 4U1BA 1YW9A 4U6ZA 1R5GA 4PV4A 1YJ3A 2GG5A 1JAWA 4KM3A 2GG9A 3IU9A 1W7VA 4FLJA 1YW8A 1WL6A 5CE6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Q93 A;  2BHC A;  5D6F A;  3MX6 A;  4S01 A;  2ZSG A;  3MAT A;  2GG7 A;  2MAT A;  4QR8 A;  4HXX A;  2BN7 A;  1W2M A;  3FMR A;  2GG2 A;  3BIP A;  3PKA A;  4FUK A;  5D6E A;  1KQ0 A;  1QXW A;  4IKS A;  5CDL A;  4OOK A;  1O0X A;  3FMQ A;  3RVA A;  1C27 A;  2V3Y A;  2ADU A;  1WBQ A;  2BHA A;  4S00 A;  3PKD A;  1PV9 A;  2GU7 A;  4FO8 A;  4IEC A;  5CIK A;  2GG3 A;  2IW2 A;  2P98 A;  3IG4 A;  3IU7 A;  4FLK A;  2V3Z A;  3ROR A;  2Q94 A;  1WN1 A;  2GZ5 A;  4U6C A;  1N51 A;  4FLI A;  2GG0 A;  2V6C A;  2BB7 A;  2GGB A;  4U6E A;  3BIT A;  3IU8 A;  3TB5 A;  4ZWU A;  5CLS A;  4Z7M A;  2BWU A;  3L24 A;  1YW7 A;  5JI6 A;  2GU6 A;  2GU4 A;  4U76 A;  3BIQ A;  1B6A A;  3PKC A;  2EVC A;  2BH3 A;  1Y1N A;  4U69 A;  4ZNG A;  1KQ9 A;  4B28 A;  1R58 A;  1M35 A;  3TAV A;  1C22 A;  2G6P A;  1XGO A;  5E5B A;  1XGS A;  2EVO A;  4IKU A;  2OAZ A;  4A6V A;  1WLR A;  4MAT A;  4FKC A;  2NQ7 A;  4FO7 A;  4RGZ 1;  2NQ6 A;  2EA2 A;  2BWW A;  4ZWO A;  2HOW A;  4IF7 A;  2BHD A;  2BWT A;  2GU5 A;  3S6B A;  2BHB A;  5FCF A;  2B3H A;  4U6W A;  1WKM A;  2P99 A;  1R5H A;  4U71 A;  1QZY A;  3CB6 A;  1MAT A;  4S2R P;  4U70 A;  2GG8 A;  4IPA A;  2Q96 A;  4IU6 A;  2EA4 A;  1XGN A;  1C24 A;  2B3K A;  2P9A A;  2BWY A;  4FLL A;  1WL9 A;  4U73 A;  5JFR A;  3CTZ A;  5FCH A;  1C23 A;  3D27 A;  2B3L A;  3PKE A;  3Q6D A;  2BWX A;  3FM3 A;  2Q95 A;  4EGE A;  2BWS A;  1QXY A;  3L7G A;  5CNX A;  4JUQ A;  3CB5 A;  4IKR A;  1XNZ A;  2GA2 A;  2GGC A;  1B59 A;  4RZY A;  2EVM A;  2Q8K A;  2GTX A;  4ZWP A;  1BN5 A;  1BOA A;  1YVM A;  4IKT A;  1WY2 A;  1C21 A;  4S2T P;  5CDE A;  5JHU A;  1QXZ A;  4RZZ A;  4U75 A;  1A16 A;  5CDV A;  2BWV A;  4A6W A;  2OKN A;  1CHM A;  2V3X A;  4R60 A;  3PKB A;  4IDY A;  2DFI A;  2Q92 A;  1KP0 A;  4PNC A;  4U6J A;  1XGM A;  3MR1 A;  4U1B A;  1YW9 A;  4U6Z A;  1R5G A;  4PV4 A;  1YJ3 A;  2GG5 A;  1JAW A;  4KM3 A;  2GG9 A;  3IU9 A;  1W7V A;  4FLJ A;  1YW8 A;  1WL6 A;  5CE6 A; 
#chains in the Genus database with same CATH topology
 2Q93 A;  2BHC A;  5D6F A;  3MX6 A;  4S01 A;  2ZSG A;  3MAT A;  2GG7 A;  2MAT A;  4QR8 A;  4HXX A;  2BN7 A;  1W2M A;  3FMR A;  2GG2 A;  3BIP A;  3PKA A;  4FUK A;  5D6E A;  1KQ0 A;  1QXW A;  4IKS A;  5CDL A;  4OOK A;  1O0X A;  3FMQ A;  3RVA A;  1C27 A;  2V3Y A;  2ADU A;  1WBQ A;  2BHA A;  4S00 A;  3PKD A;  1PV9 A;  2GU7 A;  4FO8 A;  4IEC A;  5CIK A;  2GG3 A;  2IW2 A;  2P98 A;  3IG4 A;  3IU7 A;  4FLK A;  2V3Z A;  3ROR A;  2Q94 A;  1WN1 A;  2GZ5 A;  4U6C A;  1N51 A;  4FLI A;  2GG0 A;  2V6C A;  2BB7 A;  2GGB A;  4U6E A;  3BIT A;  3IU8 A;  3TB5 A;  4ZWU A;  5CLS A;  4Z7M A;  2BWU A;  3L24 A;  1YW7 A;  5JI6 A;  2GU6 A;  2GU4 A;  4U76 A;  3BIQ A;  1B6A A;  3PKC A;  2EVC A;  2BH3 A;  1Y1N A;  4U69 A;  4ZNG A;  1KQ9 A;  4B28 A;  1R58 A;  1M35 A;  3TAV A;  1C22 A;  2G6P A;  1XGO A;  5E5B A;  1XGS A;  2EVO A;  4IKU A;  2OAZ A;  4A6V A;  1WLR A;  4MAT A;  4FKC A;  2NQ7 A;  4FO7 A;  4RGZ 1;  2NQ6 A;  2EA2 A;  2BWW A;  4ZWO A;  2HOW A;  4IF7 A;  2BHD A;  2BWT A;  2GU5 A;  3S6B A;  2BHB A;  5FCF A;  2B3H A;  4U6W A;  1WKM A;  2P99 A;  1R5H A;  4U71 A;  1QZY A;  3CB6 A;  1MAT A;  4S2R P;  4U70 A;  2GG8 A;  4IPA A;  2Q96 A;  4IU6 A;  2EA4 A;  1XGN A;  1C24 A;  2B3K A;  2P9A A;  2BWY A;  4FLL A;  1WL9 A;  4U73 A;  5JFR A;  3CTZ A;  5FCH A;  1C23 A;  3D27 A;  2B3L A;  3PKE A;  3Q6D A;  2BWX A;  3FM3 A;  2Q95 A;  4EGE A;  2BWS A;  1QXY A;  3L7G A;  5CNX A;  4JUQ A;  3CB5 A;  4IKR A;  1XNZ A;  2GA2 A;  2GGC A;  1B59 A;  4RZY A;  2EVM A;  2Q8K A;  2GTX A;  4ZWP A;  1BN5 A;  1BOA A;  1YVM A;  4IKT A;  1WY2 A;  1C21 A;  4S2T P;  5CDE A;  5JHU A;  1QXZ A;  4RZZ A;  4U75 A;  1A16 A;  5CDV A;  2BWV A;  4A6W A;  2OKN A;  1CHM A;  2V3X A;  4R60 A;  3PKB A;  4IDY A;  2DFI A;  2Q92 A;  1KP0 A;  4PNC A;  4U6J A;  1XGM A;  3MR1 A;  4U1B A;  1YW9 A;  4U6Z A;  1R5G A;  4PV4 A;  1YJ3 A;  2GG5 A;  1JAW A;  4KM3 A;  2GG9 A;  3IU9 A;  1W7V A;  4FLJ A;  1YW8 A;  1WL6 A;  5CE6 A; 
#chains in the Genus database with same CATH homology
 2Q93 A;  2BHC A;  5D6F A;  3MX6 A;  4S01 A;  2ZSG A;  3MAT A;  2GG7 A;  2MAT A;  4QR8 A;  4HXX A;  2BN7 A;  1W2M A;  3FMR A;  2GG2 A;  3BIP A;  3PKA A;  4FUK A;  5D6E A;  1KQ0 A;  1QXW A;  4IKS A;  5CDL A;  4OOK A;  1O0X A;  3FMQ A;  3RVA A;  1C27 A;  2V3Y A;  2ADU A;  1WBQ A;  2BHA A;  4S00 A;  3PKD A;  1PV9 A;  2GU7 A;  4FO8 A;  4IEC A;  5CIK A;  2GG3 A;  2IW2 A;  2P98 A;  3IG4 A;  3IU7 A;  4FLK A;  2V3Z A;  3ROR A;  2Q94 A;  1WN1 A;  2GZ5 A;  4U6C A;  1N51 A;  4FLI A;  2GG0 A;  2V6C A;  2BB7 A;  2GGB A;  4U6E A;  3BIT A;  3IU8 A;  3TB5 A;  4ZWU A;  5CLS A;  4Z7M A;  2BWU A;  3L24 A;  1YW7 A;  5JI6 A;  2GU6 A;  2GU4 A;  4U76 A;  3BIQ A;  1B6A A;  3PKC A;  2EVC A;  2BH3 A;  1Y1N A;  4U69 A;  4ZNG A;  1KQ9 A;  4B28 A;  1R58 A;  1M35 A;  3TAV A;  1C22 A;  2G6P A;  1XGO A;  5E5B A;  1XGS A;  2EVO A;  4IKU A;  2OAZ A;  4A6V A;  1WLR A;  4MAT A;  4FKC A;  2NQ7 A;  4FO7 A;  4RGZ 1;  2NQ6 A;  2EA2 A;  2BWW A;  4ZWO A;  2HOW A;  4IF7 A;  2BHD A;  2BWT A;  2GU5 A;  3S6B A;  2BHB A;  5FCF A;  2B3H A;  4U6W A;  1WKM A;  2P99 A;  1R5H A;  4U71 A;  1QZY A;  3CB6 A;  1MAT A;  4S2R P;  4U70 A;  2GG8 A;  4IPA A;  2Q96 A;  4IU6 A;  2EA4 A;  1XGN A;  1C24 A;  2B3K A;  2P9A A;  2BWY A;  4FLL A;  1WL9 A;  4U73 A;  5JFR A;  3CTZ A;  5FCH A;  1C23 A;  3D27 A;  2B3L A;  3PKE A;  3Q6D A;  2BWX A;  3FM3 A;  2Q95 A;  4EGE A;  2BWS A;  1QXY A;  3L7G A;  5CNX A;  4JUQ A;  3CB5 A;  4IKR A;  1XNZ A;  2GA2 A;  2GGC A;  1B59 A;  4RZY A;  2EVM A;  2Q8K A;  2GTX A;  4ZWP A;  1BN5 A;  1BOA A;  1YVM A;  4IKT A;  1WY2 A;  1C21 A;  4S2T P;  5CDE A;  5JHU A;  1QXZ A;  4RZZ A;  4U75 A;  1A16 A;  5CDV A;  2BWV A;  4A6W A;  2OKN A;  1CHM A;  2V3X A;  4R60 A;  3PKB A;  4IDY A;  2DFI A;  2Q92 A;  1KP0 A;  4PNC A;  4U6J A;  1XGM A;  3MR1 A;  4U1B A;  1YW9 A;  4U6Z A;  1R5G A;  4PV4 A;  1YJ3 A;  2GG5 A;  1JAW A;  4KM3 A;  2GG9 A;  3IU9 A;  1W7V A;  4FLJ A;  1YW8 A;  1WL6 A;  5CE6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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