2GGCA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 87
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggcA00
1YW8A 4S00A 4FKCA 2BWSA 2Q94A 2Q92A 4IKTA 2BHAA 4U75A 5CE6A 5JFRA 4RZZA 2GG5A 1N51A 1JAWA 1C27A 3L24A 4U69A 2B3HA 2GGBA 4S2RP 4QR8A 5D6EA 3TB5A 1XGSA 1BOAA 2ZSGA 2NQ6A 4ZWUA 4HXXA 1CHMA 3FM3A 4B28A 4U71A 4FO8A 2BWWA 2MATA 5CDVA 1WL9A 2GA2A 4IKUA 1MATA 1KQ9A 2BB7A 2IW2A 4EGEA 3CB6A 1W7VA 4RZYA 3BITA 1YW7A 2EVOA 3D27A 2ADUA 5E5BA 1WKMA 2GU6A 1YW9A 3IU8A 2BWXA 1WN1A 4Z7MA 1QXYA 1Y1NA 2BHDA 3BIPA 4U6ZA 4IPAA 1C24A 1BN5A 1M35A 1WL6A 2GG8A 2GU7A 1R5GA 1WLRA 5CLSA 1R5HA 5CIKA 1XGOA 2GU5A 3CTZA 4U73A 4MATA 2V3ZA 2G6PA 3RVAA 2B3LA 2GU4A 4FLLA 2BHCA 2EVCA 2V6CA 4IKRA 2BWYA 1WBQA 1O0XA 4IF7A 2OKNA 1KQ0A 4PV4A 2OAZA 2BH3A 4U6EA 2GG7A 4U6CA 1QXZA 5CDLA 1A16A 4KM3A 4RGZ1 1C22A 1R58A 2BHBA 3RORA 1YJ3A 3MR1A 2V3YA 3S6BA 2BWTA 4S01A 4PNCA 1B59A 5JHUA 2Q8KA 4FLKA 2GG9A 3Q6DA 5JI6A 2DFIA 1KP0A 2EA4A 3PKDA 5D6FA 4ZNGA 5FCHA 3BIQA 4IECA 2GZ5A 4JUQA 4S2TP 3MATA 2BWUA 2V3XA 3MX6A 2NQ7A 4OOKA 1XGMA 4U6JA 4IKSA 1W2MA 4FO7A 4A6VA 4R60A 4U6WA 2GGCA 4FLIA 2EA2A 3IG4A 3IU7A 1QXWA 4FUKA 2BWVA 5CNXA 1PV9A 1C21A 2B3KA 2P98A 3PKCA 4A6WA 3CB5A 3PKEA 4ZWOA 2GG0A 1QZYA 2Q96A 2P9AA 3PKBA 2BN7A 2P99A 2GG3A 3L7GA 4FLJA 4IDYA 2HOWA 4U1BA 1WY2A 1B6AA 3TAVA 1C23A 1XNZA 5FCFA 2Q95A 4IU6A 4U70A 1YVMA 2EVMA 3FMRA 3IU9A 5CDEA 2GG2A 4U76A 3PKAA 2GTXA 4ZWPA 1XGNA 2Q93A 3FMQA
chains in the Genus database with same CATH superfamily
1YW8A 4S00A 4FKCA 2BWSA 2Q94A 2Q92A 4IKTA 2BHAA 4U75A 5CE6A 5JFRA 4RZZA 2GG5A 1N51A 1JAWA 1C27A 3L24A 4U69A 2B3HA 2GGBA 4S2RP 4QR8A 5D6EA 3TB5A 1XGSA 1BOAA 2ZSGA 2NQ6A 4ZWUA 4HXXA 1CHMA 3FM3A 4B28A 4U71A 4FO8A 2BWWA 2MATA 5CDVA 1WL9A 2GA2A 4IKUA 1MATA 1KQ9A 2BB7A 2IW2A 4EGEA 3CB6A 1W7VA 4RZYA 3BITA 1YW7A 2EVOA 3D27A 2ADUA 5E5BA 1WKMA 2GU6A 1YW9A 3IU8A 2BWXA 1WN1A 4Z7MA 1QXYA 1Y1NA 2BHDA 3BIPA 4U6ZA 4IPAA 1C24A 1BN5A 1M35A 1WL6A 2GG8A 2GU7A 1R5GA 1WLRA 5CLSA 1R5HA 5CIKA 1XGOA 2GU5A 3CTZA 4U73A 4MATA 2V3ZA 2G6PA 3RVAA 2B3LA 2GU4A 4FLLA 2BHCA 2EVCA 2V6CA 4IKRA 2BWYA 1WBQA 1O0XA 4IF7A 2OKNA 1KQ0A 4PV4A 2OAZA 2BH3A 4U6EA 2GG7A 4U6CA 1QXZA 5CDLA 1A16A 4KM3A 4RGZ1 1C22A 1R58A 2BHBA 3RORA 1YJ3A 3MR1A 2V3YA 3S6BA 2BWTA 4S01A 4PNCA 1B59A 5JHUA 2Q8KA 4FLKA 2GG9A 3Q6DA 5JI6A 2DFIA 1KP0A 2EA4A 3PKDA 5D6FA 4ZNGA 5FCHA 3BIQA 4IECA 2GZ5A 4JUQA 4S2TP 3MATA 2BWUA 2V3XA 3MX6A 2NQ7A 4OOKA 1XGMA 4U6JA 4IKSA 1W2MA 4FO7A 4A6VA 4R60A 4U6WA 2GGCA 4FLIA 2EA2A 3IG4A 3IU7A 1QXWA 4FUKA 2BWVA 5CNXA 1PV9A 1C21A 2B3KA 2P98A 3PKCA 4A6WA 3CB5A 3PKEA 4ZWOA 2GG0A 1QZYA 2Q96A 2P9AA 3PKBA 2BN7A 2P99A 2GG3A 3L7GA 4FLJA 4IDYA 2HOWA 4U1BA 1WY2A 1B6AA 3TAVA 1C23A 1XNZA 5FCFA 2Q95A 4IU6A 4U70A 1YVMA 2EVMA 3FMRA 3IU9A 5CDEA 2GG2A 4U76A 3PKAA 2GTXA 4ZWPA 1XGNA 2Q93A 3FMQA
chains in the Genus database with same CATH topology
1YW8A 4S00A 4FKCA 2BWSA 2Q94A 2Q92A 4IKTA 2BHAA 4U75A 5CE6A 5JFRA 4RZZA 2GG5A 1N51A 1JAWA 1C27A 3L24A 4U69A 2B3HA 2GGBA 4S2RP 4QR8A 5D6EA 3TB5A 1XGSA 1BOAA 2ZSGA 2NQ6A 4ZWUA 4HXXA 1CHMA 3FM3A 4B28A 4U71A 4FO8A 2BWWA 2MATA 5CDVA 1WL9A 2GA2A 4IKUA 1MATA 1KQ9A 2BB7A 2IW2A 4EGEA 3CB6A 1W7VA 4RZYA 3BITA 1YW7A 2EVOA 3D27A 2ADUA 5E5BA 1WKMA 2GU6A 1YW9A 3IU8A 2BWXA 1WN1A 4Z7MA 1QXYA 1Y1NA 2BHDA 3BIPA 4U6ZA 4IPAA 1C24A 1BN5A 1M35A 1WL6A 2GG8A 2GU7A 1R5GA 1WLRA 5CLSA 1R5HA 5CIKA 1XGOA 2GU5A 3CTZA 4U73A 4MATA 2V3ZA 2G6PA 3RVAA 2B3LA 2GU4A 4FLLA 2BHCA 2EVCA 2V6CA 4IKRA 2BWYA 1WBQA 1O0XA 4IF7A 2OKNA 1KQ0A 4PV4A 2OAZA 2BH3A 4U6EA 2GG7A 4U6CA 1QXZA 5CDLA 1A16A 4KM3A 4RGZ1 1C22A 1R58A 2BHBA 3RORA 1YJ3A 3MR1A 2V3YA 3S6BA 2BWTA 4S01A 4PNCA 1B59A 5JHUA 2Q8KA 4FLKA 2GG9A 3Q6DA 5JI6A 2DFIA 1KP0A 2EA4A 3PKDA 5D6FA 4ZNGA 5FCHA 3BIQA 4IECA 2GZ5A 4JUQA 4S2TP 3MATA 2BWUA 2V3XA 3MX6A 2NQ7A 4OOKA 1XGMA 4U6JA 4IKSA 1W2MA 4FO7A 4A6VA 4R60A 4U6WA 2GGCA 4FLIA 2EA2A 3IG4A 3IU7A 1QXWA 4FUKA 2BWVA 5CNXA 1PV9A 1C21A 2B3KA 2P98A 3PKCA 4A6WA 3CB5A 3PKEA 4ZWOA 2GG0A 1QZYA 2Q96A 2P9AA 3PKBA 2BN7A 2P99A 2GG3A 3L7GA 4FLJA 4IDYA 2HOWA 4U1BA 1WY2A 1B6AA 3TAVA 1C23A 1XNZA 5FCFA 2Q95A 4IU6A 4U70A 1YVMA 2EVMA 3FMRA 3IU9A 5CDEA 2GG2A 4U76A 3PKAA 2GTXA 4ZWPA 1XGNA 2Q93A 3FMQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YW8 A;  4S00 A;  4FKC A;  2BWS A;  2Q94 A;  2Q92 A;  4IKT A;  2BHA A;  4U75 A;  5CE6 A;  5JFR A;  4RZZ A;  2GG5 A;  1N51 A;  1JAW A;  1C27 A;  3L24 A;  4U69 A;  2B3H A;  2GGB A;  4S2R P;  4QR8 A;  5D6E A;  3TB5 A;  1XGS A;  1BOA A;  2ZSG A;  2NQ6 A;  4ZWU A;  4HXX A;  1CHM A;  3FM3 A;  4B28 A;  4U71 A;  4FO8 A;  2BWW A;  2MAT A;  5CDV A;  1WL9 A;  2GA2 A;  4IKU A;  1MAT A;  1KQ9 A;  2BB7 A;  2IW2 A;  4EGE A;  3CB6 A;  1W7V A;  4RZY A;  3BIT A;  1YW7 A;  2EVO A;  3D27 A;  2ADU A;  5E5B A;  1WKM A;  2GU6 A;  1YW9 A;  3IU8 A;  2BWX A;  1WN1 A;  4Z7M A;  1QXY A;  1Y1N A;  2BHD A;  3BIP A;  4U6Z A;  4IPA A;  1C24 A;  1BN5 A;  1M35 A;  1WL6 A;  2GG8 A;  2GU7 A;  1R5G A;  1WLR A;  5CLS A;  1R5H A;  5CIK A;  1XGO A;  2GU5 A;  3CTZ A;  4U73 A;  4MAT A;  2V3Z A;  2G6P A;  3RVA A;  2B3L A;  2GU4 A;  4FLL A;  2BHC A;  2EVC A;  2V6C A;  4IKR A;  2BWY A;  1WBQ A;  1O0X A;  4IF7 A;  2OKN A;  1KQ0 A;  4PV4 A;  2OAZ A;  2BH3 A;  4U6E A;  2GG7 A;  4U6C A;  1QXZ A;  5CDL A;  1A16 A;  4KM3 A;  4RGZ 1;  1C22 A;  1R58 A;  2BHB A;  3ROR A;  1YJ3 A;  3MR1 A;  2V3Y A;  3S6B A;  2BWT A;  4S01 A;  4PNC A;  1B59 A;  5JHU A;  2Q8K A;  4FLK A;  2GG9 A;  3Q6D A;  5JI6 A;  2DFI A;  1KP0 A;  2EA4 A;  3PKD A;  5D6F A;  4ZNG A;  5FCH A;  3BIQ A;  4IEC A;  2GZ5 A;  4JUQ A;  4S2T P;  3MAT A;  2BWU A;  2V3X A;  3MX6 A;  2NQ7 A;  4OOK A;  1XGM A;  4U6J A;  4IKS A;  1W2M A;  4FO7 A;  4A6V A;  4R60 A;  4U6W A;  2GGC A;  4FLI A;  2EA2 A;  3IG4 A;  3IU7 A;  1QXW A;  4FUK A;  2BWV A;  5CNX A;  1PV9 A;  1C21 A;  2B3K A;  2P98 A;  3PKC A;  4A6W A;  3CB5 A;  3PKE A;  4ZWO A;  2GG0 A;  1QZY A;  2Q96 A;  2P9A A;  3PKB A;  2BN7 A;  2P99 A;  2GG3 A;  3L7G A;  4FLJ A;  4IDY A;  2HOW A;  4U1B A;  1WY2 A;  1B6A A;  3TAV A;  1C23 A;  1XNZ A;  5FCF A;  2Q95 A;  4IU6 A;  4U70 A;  1YVM A;  2EVM A;  3FMR A;  3IU9 A;  5CDE A;  2GG2 A;  4U76 A;  3PKA A;  2GTX A;  4ZWP A;  1XGN A;  2Q93 A;  3FMQ A; 
#chains in the Genus database with same CATH topology
 1YW8 A;  4S00 A;  4FKC A;  2BWS A;  2Q94 A;  2Q92 A;  4IKT A;  2BHA A;  4U75 A;  5CE6 A;  5JFR A;  4RZZ A;  2GG5 A;  1N51 A;  1JAW A;  1C27 A;  3L24 A;  4U69 A;  2B3H A;  2GGB A;  4S2R P;  4QR8 A;  5D6E A;  3TB5 A;  1XGS A;  1BOA A;  2ZSG A;  2NQ6 A;  4ZWU A;  4HXX A;  1CHM A;  3FM3 A;  4B28 A;  4U71 A;  4FO8 A;  2BWW A;  2MAT A;  5CDV A;  1WL9 A;  2GA2 A;  4IKU A;  1MAT A;  1KQ9 A;  2BB7 A;  2IW2 A;  4EGE A;  3CB6 A;  1W7V A;  4RZY A;  3BIT A;  1YW7 A;  2EVO A;  3D27 A;  2ADU A;  5E5B A;  1WKM A;  2GU6 A;  1YW9 A;  3IU8 A;  2BWX A;  1WN1 A;  4Z7M A;  1QXY A;  1Y1N A;  2BHD A;  3BIP A;  4U6Z A;  4IPA A;  1C24 A;  1BN5 A;  1M35 A;  1WL6 A;  2GG8 A;  2GU7 A;  1R5G A;  1WLR A;  5CLS A;  1R5H A;  5CIK A;  1XGO A;  2GU5 A;  3CTZ A;  4U73 A;  4MAT A;  2V3Z A;  2G6P A;  3RVA A;  2B3L A;  2GU4 A;  4FLL A;  2BHC A;  2EVC A;  2V6C A;  4IKR A;  2BWY A;  1WBQ A;  1O0X A;  4IF7 A;  2OKN A;  1KQ0 A;  4PV4 A;  2OAZ A;  2BH3 A;  4U6E A;  2GG7 A;  4U6C A;  1QXZ A;  5CDL A;  1A16 A;  4KM3 A;  4RGZ 1;  1C22 A;  1R58 A;  2BHB A;  3ROR A;  1YJ3 A;  3MR1 A;  2V3Y A;  3S6B A;  2BWT A;  4S01 A;  4PNC A;  1B59 A;  5JHU A;  2Q8K A;  4FLK A;  2GG9 A;  3Q6D A;  5JI6 A;  2DFI A;  1KP0 A;  2EA4 A;  3PKD A;  5D6F A;  4ZNG A;  5FCH A;  3BIQ A;  4IEC A;  2GZ5 A;  4JUQ A;  4S2T P;  3MAT A;  2BWU A;  2V3X A;  3MX6 A;  2NQ7 A;  4OOK A;  1XGM A;  4U6J A;  4IKS A;  1W2M A;  4FO7 A;  4A6V A;  4R60 A;  4U6W A;  2GGC A;  4FLI A;  2EA2 A;  3IG4 A;  3IU7 A;  1QXW A;  4FUK A;  2BWV A;  5CNX A;  1PV9 A;  1C21 A;  2B3K A;  2P98 A;  3PKC A;  4A6W A;  3CB5 A;  3PKE A;  4ZWO A;  2GG0 A;  1QZY A;  2Q96 A;  2P9A A;  3PKB A;  2BN7 A;  2P99 A;  2GG3 A;  3L7G A;  4FLJ A;  4IDY A;  2HOW A;  4U1B A;  1WY2 A;  1B6A A;  3TAV A;  1C23 A;  1XNZ A;  5FCF A;  2Q95 A;  4IU6 A;  4U70 A;  1YVM A;  2EVM A;  3FMR A;  3IU9 A;  5CDE A;  2GG2 A;  4U76 A;  3PKA A;  2GTX A;  4ZWP A;  1XGN A;  2Q93 A;  3FMQ A; 
#chains in the Genus database with same CATH homology
 1YW8 A;  4S00 A;  4FKC A;  2BWS A;  2Q94 A;  2Q92 A;  4IKT A;  2BHA A;  4U75 A;  5CE6 A;  5JFR A;  4RZZ A;  2GG5 A;  1N51 A;  1JAW A;  1C27 A;  3L24 A;  4U69 A;  2B3H A;  2GGB A;  4S2R P;  4QR8 A;  5D6E A;  3TB5 A;  1XGS A;  1BOA A;  2ZSG A;  2NQ6 A;  4ZWU A;  4HXX A;  1CHM A;  3FM3 A;  4B28 A;  4U71 A;  4FO8 A;  2BWW A;  2MAT A;  5CDV A;  1WL9 A;  2GA2 A;  4IKU A;  1MAT A;  1KQ9 A;  2BB7 A;  2IW2 A;  4EGE A;  3CB6 A;  1W7V A;  4RZY A;  3BIT A;  1YW7 A;  2EVO A;  3D27 A;  2ADU A;  5E5B A;  1WKM A;  2GU6 A;  1YW9 A;  3IU8 A;  2BWX A;  1WN1 A;  4Z7M A;  1QXY A;  1Y1N A;  2BHD A;  3BIP A;  4U6Z A;  4IPA A;  1C24 A;  1BN5 A;  1M35 A;  1WL6 A;  2GG8 A;  2GU7 A;  1R5G A;  1WLR A;  5CLS A;  1R5H A;  5CIK A;  1XGO A;  2GU5 A;  3CTZ A;  4U73 A;  4MAT A;  2V3Z A;  2G6P A;  3RVA A;  2B3L A;  2GU4 A;  4FLL A;  2BHC A;  2EVC A;  2V6C A;  4IKR A;  2BWY A;  1WBQ A;  1O0X A;  4IF7 A;  2OKN A;  1KQ0 A;  4PV4 A;  2OAZ A;  2BH3 A;  4U6E A;  2GG7 A;  4U6C A;  1QXZ A;  5CDL A;  1A16 A;  4KM3 A;  4RGZ 1;  1C22 A;  1R58 A;  2BHB A;  3ROR A;  1YJ3 A;  3MR1 A;  2V3Y A;  3S6B A;  2BWT A;  4S01 A;  4PNC A;  1B59 A;  5JHU A;  2Q8K A;  4FLK A;  2GG9 A;  3Q6D A;  5JI6 A;  2DFI A;  1KP0 A;  2EA4 A;  3PKD A;  5D6F A;  4ZNG A;  5FCH A;  3BIQ A;  4IEC A;  2GZ5 A;  4JUQ A;  4S2T P;  3MAT A;  2BWU A;  2V3X A;  3MX6 A;  2NQ7 A;  4OOK A;  1XGM A;  4U6J A;  4IKS A;  1W2M A;  4FO7 A;  4A6V A;  4R60 A;  4U6W A;  2GGC A;  4FLI A;  2EA2 A;  3IG4 A;  3IU7 A;  1QXW A;  4FUK A;  2BWV A;  5CNX A;  1PV9 A;  1C21 A;  2B3K A;  2P98 A;  3PKC A;  4A6W A;  3CB5 A;  3PKE A;  4ZWO A;  2GG0 A;  1QZY A;  2Q96 A;  2P9A A;  3PKB A;  2BN7 A;  2P99 A;  2GG3 A;  3L7G A;  4FLJ A;  4IDY A;  2HOW A;  4U1B A;  1WY2 A;  1B6A A;  3TAV A;  1C23 A;  1XNZ A;  5FCF A;  2Q95 A;  4IU6 A;  4U70 A;  1YVM A;  2EVM A;  3FMR A;  3IU9 A;  5CDE A;  2GG2 A;  4U76 A;  3PKA A;  2GTX A;  4ZWP A;  1XGN A;  2Q93 A;  3FMQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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