2GGCA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 87
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggcA00
1N51A 2Q92A 4U71A 3PKDA 2BHBA 2EVCA 4IKSA 1B6AA 2B3HA 1XGSA 2ADUA 2HOWA 2P9AA 3CB6A 3MR1A 2GG2A 2B3KA 2ZSGA 5CLSA 4U6EA 3PKBA 3L24A 5FCHA 4FLIA 1MATA 1BN5A 1C23A 4RGZ1 1YW9A 2V3XA 2GU7A 2BH3A 4RZZA 4U73A 4R60A 5E5BA 3BITA 2Q96A 4S00A 1R58A 1XNZA 1M35A 2NQ6A 2EVMA 5D6EA 1W2MA 2GU4A 4IKTA 1R5HA 1WL6A 5CIKA 1YJ3A 3S6BA 2OKNA 1YW7A 2EA2A 1QXZA 2GA2A 4Z7MA 1C22A 2BHCA 2V3ZA 1JAWA 2Q95A 4EGEA 2BHAA 4FO7A 1A16A 4U6ZA 5CDVA 1B59A 1PV9A 1W7VA 2GGCA 2GZ5A 3FM3A 4KM3A 5CDLA 1YW8A 5FCFA 4OOKA 4S01A 2GG3A 4A6WA 5JFRA 1YVMA 4IU6A 4PNCA 4QR8A 2NQ7A 2GG7A 4FKCA 4IDYA 3TAVA 2BHDA 4ZWOA 1WN1A 3FMQA 3Q6DA 1R5GA 1C21A 4U1BA 1WLRA 3IU8A 1WL9A 4U76A 2Q8KA 4U6WA 3RORA 2GG9A 4S2RP 4MATA 4U69A 1KP0A 2GTXA 4B28A 2P98A 4RZYA 3PKCA 3PKEA 1KQ0A 5JHUA 1C27A 2GU6A 1O0XA 2GG0A 2Q93A 4PV4A 2GU5A 1QXYA 4A6VA 4FLKA 4JUQA 3CTZA 3L7GA 4FLLA 2MATA 3TB5A 2IW2A 4ZWUA 2GG8A 1QZYA 1C24A 2OAZA 4U75A 4IKRA 4FO8A 4IKUA 3IU7A 1XGMA 1WKMA 4S2TP 2BWWA 4IECA 4ZNGA 1WBQA 2BWVA 4HXXA 3MATA 2EVOA 2BWUA 2Q94A 1XGOA 2G6PA 2BN7A 2GG5A 4ZWPA 2V3YA 5CNXA 4U6CA 2BB7A 1WY2A 3PKAA 1Y1NA 4FUKA 2BWSA 1QXWA 2B3LA 4U70A 5CE6A 4IPAA 2P99A 3CB5A 3BIQA 3IG4A 4U6JA 2EA4A 5CDEA 3MX6A 5JI6A 1BOAA 3IU9A 2BWXA 2V6CA 2BWTA 3RVAA 3D27A 4FLJA 5D6FA 4IF7A 1XGNA 3FMRA 2BWYA 2GGBA 1CHMA 3BIPA 2DFIA 1KQ9A
chains in the Genus database with same CATH superfamily
1N51A 2Q92A 4U71A 3PKDA 2BHBA 2EVCA 4IKSA 1B6AA 2B3HA 1XGSA 2ADUA 2HOWA 2P9AA 3CB6A 3MR1A 2GG2A 2B3KA 2ZSGA 5CLSA 4U6EA 3PKBA 3L24A 5FCHA 4FLIA 1MATA 1BN5A 1C23A 4RGZ1 1YW9A 2V3XA 2GU7A 2BH3A 4RZZA 4U73A 4R60A 5E5BA 3BITA 2Q96A 4S00A 1R58A 1XNZA 1M35A 2NQ6A 2EVMA 5D6EA 1W2MA 2GU4A 4IKTA 1R5HA 1WL6A 5CIKA 1YJ3A 3S6BA 2OKNA 1YW7A 2EA2A 1QXZA 2GA2A 4Z7MA 1C22A 2BHCA 2V3ZA 1JAWA 2Q95A 4EGEA 2BHAA 4FO7A 1A16A 4U6ZA 5CDVA 1B59A 1PV9A 1W7VA 2GGCA 2GZ5A 3FM3A 4KM3A 5CDLA 1YW8A 5FCFA 4OOKA 4S01A 2GG3A 4A6WA 5JFRA 1YVMA 4IU6A 4PNCA 4QR8A 2NQ7A 2GG7A 4FKCA 4IDYA 3TAVA 2BHDA 4ZWOA 1WN1A 3FMQA 3Q6DA 1R5GA 1C21A 4U1BA 1WLRA 3IU8A 1WL9A 4U76A 2Q8KA 4U6WA 3RORA 2GG9A 4S2RP 4MATA 4U69A 1KP0A 2GTXA 4B28A 2P98A 4RZYA 3PKCA 3PKEA 1KQ0A 5JHUA 1C27A 2GU6A 1O0XA 2GG0A 2Q93A 4PV4A 2GU5A 1QXYA 4A6VA 4FLKA 4JUQA 3CTZA 3L7GA 4FLLA 2MATA 3TB5A 2IW2A 4ZWUA 2GG8A 1QZYA 1C24A 2OAZA 4U75A 4IKRA 4FO8A 4IKUA 3IU7A 1XGMA 1WKMA 4S2TP 2BWWA 4IECA 4ZNGA 1WBQA 2BWVA 4HXXA 3MATA 2EVOA 2BWUA 2Q94A 1XGOA 2G6PA 2BN7A 2GG5A 4ZWPA 2V3YA 5CNXA 4U6CA 2BB7A 1WY2A 3PKAA 1Y1NA 4FUKA 2BWSA 1QXWA 2B3LA 4U70A 5CE6A 4IPAA 2P99A 3CB5A 3BIQA 3IG4A 4U6JA 2EA4A 5CDEA 3MX6A 5JI6A 1BOAA 3IU9A 2BWXA 2V6CA 2BWTA 3RVAA 3D27A 4FLJA 5D6FA 4IF7A 1XGNA 3FMRA 2BWYA 2GGBA 1CHMA 3BIPA 2DFIA 1KQ9A
chains in the Genus database with same CATH topology
1N51A 2Q92A 4U71A 3PKDA 2BHBA 2EVCA 4IKSA 1B6AA 2B3HA 1XGSA 2ADUA 2HOWA 2P9AA 3CB6A 3MR1A 2GG2A 2B3KA 2ZSGA 5CLSA 4U6EA 3PKBA 3L24A 5FCHA 4FLIA 1MATA 1BN5A 1C23A 4RGZ1 1YW9A 2V3XA 2GU7A 2BH3A 4RZZA 4U73A 4R60A 5E5BA 3BITA 2Q96A 4S00A 1R58A 1XNZA 1M35A 2NQ6A 2EVMA 5D6EA 1W2MA 2GU4A 4IKTA 1R5HA 1WL6A 5CIKA 1YJ3A 3S6BA 2OKNA 1YW7A 2EA2A 1QXZA 2GA2A 4Z7MA 1C22A 2BHCA 2V3ZA 1JAWA 2Q95A 4EGEA 2BHAA 4FO7A 1A16A 4U6ZA 5CDVA 1B59A 1PV9A 1W7VA 2GGCA 2GZ5A 3FM3A 4KM3A 5CDLA 1YW8A 5FCFA 4OOKA 4S01A 2GG3A 4A6WA 5JFRA 1YVMA 4IU6A 4PNCA 4QR8A 2NQ7A 2GG7A 4FKCA 4IDYA 3TAVA 2BHDA 4ZWOA 1WN1A 3FMQA 3Q6DA 1R5GA 1C21A 4U1BA 1WLRA 3IU8A 1WL9A 4U76A 2Q8KA 4U6WA 3RORA 2GG9A 4S2RP 4MATA 4U69A 1KP0A 2GTXA 4B28A 2P98A 4RZYA 3PKCA 3PKEA 1KQ0A 5JHUA 1C27A 2GU6A 1O0XA 2GG0A 2Q93A 4PV4A 2GU5A 1QXYA 4A6VA 4FLKA 4JUQA 3CTZA 3L7GA 4FLLA 2MATA 3TB5A 2IW2A 4ZWUA 2GG8A 1QZYA 1C24A 2OAZA 4U75A 4IKRA 4FO8A 4IKUA 3IU7A 1XGMA 1WKMA 4S2TP 2BWWA 4IECA 4ZNGA 1WBQA 2BWVA 4HXXA 3MATA 2EVOA 2BWUA 2Q94A 1XGOA 2G6PA 2BN7A 2GG5A 4ZWPA 2V3YA 5CNXA 4U6CA 2BB7A 1WY2A 3PKAA 1Y1NA 4FUKA 2BWSA 1QXWA 2B3LA 4U70A 5CE6A 4IPAA 2P99A 3CB5A 3BIQA 3IG4A 4U6JA 2EA4A 5CDEA 3MX6A 5JI6A 1BOAA 3IU9A 2BWXA 2V6CA 2BWTA 3RVAA 3D27A 4FLJA 5D6FA 4IF7A 1XGNA 3FMRA 2BWYA 2GGBA 1CHMA 3BIPA 2DFIA 1KQ9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1N51 A;  2Q92 A;  4U71 A;  3PKD A;  2BHB A;  2EVC A;  4IKS A;  1B6A A;  2B3H A;  1XGS A;  2ADU A;  2HOW A;  2P9A A;  3CB6 A;  3MR1 A;  2GG2 A;  2B3K A;  2ZSG A;  5CLS A;  4U6E A;  3PKB A;  3L24 A;  5FCH A;  4FLI A;  1MAT A;  1BN5 A;  1C23 A;  4RGZ 1;  1YW9 A;  2V3X A;  2GU7 A;  2BH3 A;  4RZZ A;  4U73 A;  4R60 A;  5E5B A;  3BIT A;  2Q96 A;  4S00 A;  1R58 A;  1XNZ A;  1M35 A;  2NQ6 A;  2EVM A;  5D6E A;  1W2M A;  2GU4 A;  4IKT A;  1R5H A;  1WL6 A;  5CIK A;  1YJ3 A;  3S6B A;  2OKN A;  1YW7 A;  2EA2 A;  1QXZ A;  2GA2 A;  4Z7M A;  1C22 A;  2BHC A;  2V3Z A;  1JAW A;  2Q95 A;  4EGE A;  2BHA A;  4FO7 A;  1A16 A;  4U6Z A;  5CDV A;  1B59 A;  1PV9 A;  1W7V A;  2GGC A;  2GZ5 A;  3FM3 A;  4KM3 A;  5CDL A;  1YW8 A;  5FCF A;  4OOK A;  4S01 A;  2GG3 A;  4A6W A;  5JFR A;  1YVM A;  4IU6 A;  4PNC A;  4QR8 A;  2NQ7 A;  2GG7 A;  4FKC A;  4IDY A;  3TAV A;  2BHD A;  4ZWO A;  1WN1 A;  3FMQ A;  3Q6D A;  1R5G A;  1C21 A;  4U1B A;  1WLR A;  3IU8 A;  1WL9 A;  4U76 A;  2Q8K A;  4U6W A;  3ROR A;  2GG9 A;  4S2R P;  4MAT A;  4U69 A;  1KP0 A;  2GTX A;  4B28 A;  2P98 A;  4RZY A;  3PKC A;  3PKE A;  1KQ0 A;  5JHU A;  1C27 A;  2GU6 A;  1O0X A;  2GG0 A;  2Q93 A;  4PV4 A;  2GU5 A;  1QXY A;  4A6V A;  4FLK A;  4JUQ A;  3CTZ A;  3L7G A;  4FLL A;  2MAT A;  3TB5 A;  2IW2 A;  4ZWU A;  2GG8 A;  1QZY A;  1C24 A;  2OAZ A;  4U75 A;  4IKR A;  4FO8 A;  4IKU A;  3IU7 A;  1XGM A;  1WKM A;  4S2T P;  2BWW A;  4IEC A;  4ZNG A;  1WBQ A;  2BWV A;  4HXX A;  3MAT A;  2EVO A;  2BWU A;  2Q94 A;  1XGO A;  2G6P A;  2BN7 A;  2GG5 A;  4ZWP A;  2V3Y A;  5CNX A;  4U6C A;  2BB7 A;  1WY2 A;  3PKA A;  1Y1N A;  4FUK A;  2BWS A;  1QXW A;  2B3L A;  4U70 A;  5CE6 A;  4IPA A;  2P99 A;  3CB5 A;  3BIQ A;  3IG4 A;  4U6J A;  2EA4 A;  5CDE A;  3MX6 A;  5JI6 A;  1BOA A;  3IU9 A;  2BWX A;  2V6C A;  2BWT A;  3RVA A;  3D27 A;  4FLJ A;  5D6F A;  4IF7 A;  1XGN A;  3FMR A;  2BWY A;  2GGB A;  1CHM A;  3BIP A;  2DFI A;  1KQ9 A; 
#chains in the Genus database with same CATH topology
 1N51 A;  2Q92 A;  4U71 A;  3PKD A;  2BHB A;  2EVC A;  4IKS A;  1B6A A;  2B3H A;  1XGS A;  2ADU A;  2HOW A;  2P9A A;  3CB6 A;  3MR1 A;  2GG2 A;  2B3K A;  2ZSG A;  5CLS A;  4U6E A;  3PKB A;  3L24 A;  5FCH A;  4FLI A;  1MAT A;  1BN5 A;  1C23 A;  4RGZ 1;  1YW9 A;  2V3X A;  2GU7 A;  2BH3 A;  4RZZ A;  4U73 A;  4R60 A;  5E5B A;  3BIT A;  2Q96 A;  4S00 A;  1R58 A;  1XNZ A;  1M35 A;  2NQ6 A;  2EVM A;  5D6E A;  1W2M A;  2GU4 A;  4IKT A;  1R5H A;  1WL6 A;  5CIK A;  1YJ3 A;  3S6B A;  2OKN A;  1YW7 A;  2EA2 A;  1QXZ A;  2GA2 A;  4Z7M A;  1C22 A;  2BHC A;  2V3Z A;  1JAW A;  2Q95 A;  4EGE A;  2BHA A;  4FO7 A;  1A16 A;  4U6Z A;  5CDV A;  1B59 A;  1PV9 A;  1W7V A;  2GGC A;  2GZ5 A;  3FM3 A;  4KM3 A;  5CDL A;  1YW8 A;  5FCF A;  4OOK A;  4S01 A;  2GG3 A;  4A6W A;  5JFR A;  1YVM A;  4IU6 A;  4PNC A;  4QR8 A;  2NQ7 A;  2GG7 A;  4FKC A;  4IDY A;  3TAV A;  2BHD A;  4ZWO A;  1WN1 A;  3FMQ A;  3Q6D A;  1R5G A;  1C21 A;  4U1B A;  1WLR A;  3IU8 A;  1WL9 A;  4U76 A;  2Q8K A;  4U6W A;  3ROR A;  2GG9 A;  4S2R P;  4MAT A;  4U69 A;  1KP0 A;  2GTX A;  4B28 A;  2P98 A;  4RZY A;  3PKC A;  3PKE A;  1KQ0 A;  5JHU A;  1C27 A;  2GU6 A;  1O0X A;  2GG0 A;  2Q93 A;  4PV4 A;  2GU5 A;  1QXY A;  4A6V A;  4FLK A;  4JUQ A;  3CTZ A;  3L7G A;  4FLL A;  2MAT A;  3TB5 A;  2IW2 A;  4ZWU A;  2GG8 A;  1QZY A;  1C24 A;  2OAZ A;  4U75 A;  4IKR A;  4FO8 A;  4IKU A;  3IU7 A;  1XGM A;  1WKM A;  4S2T P;  2BWW A;  4IEC A;  4ZNG A;  1WBQ A;  2BWV A;  4HXX A;  3MAT A;  2EVO A;  2BWU A;  2Q94 A;  1XGO A;  2G6P A;  2BN7 A;  2GG5 A;  4ZWP A;  2V3Y A;  5CNX A;  4U6C A;  2BB7 A;  1WY2 A;  3PKA A;  1Y1N A;  4FUK A;  2BWS A;  1QXW A;  2B3L A;  4U70 A;  5CE6 A;  4IPA A;  2P99 A;  3CB5 A;  3BIQ A;  3IG4 A;  4U6J A;  2EA4 A;  5CDE A;  3MX6 A;  5JI6 A;  1BOA A;  3IU9 A;  2BWX A;  2V6C A;  2BWT A;  3RVA A;  3D27 A;  4FLJ A;  5D6F A;  4IF7 A;  1XGN A;  3FMR A;  2BWY A;  2GGB A;  1CHM A;  3BIP A;  2DFI A;  1KQ9 A; 
#chains in the Genus database with same CATH homology
 1N51 A;  2Q92 A;  4U71 A;  3PKD A;  2BHB A;  2EVC A;  4IKS A;  1B6A A;  2B3H A;  1XGS A;  2ADU A;  2HOW A;  2P9A A;  3CB6 A;  3MR1 A;  2GG2 A;  2B3K A;  2ZSG A;  5CLS A;  4U6E A;  3PKB A;  3L24 A;  5FCH A;  4FLI A;  1MAT A;  1BN5 A;  1C23 A;  4RGZ 1;  1YW9 A;  2V3X A;  2GU7 A;  2BH3 A;  4RZZ A;  4U73 A;  4R60 A;  5E5B A;  3BIT A;  2Q96 A;  4S00 A;  1R58 A;  1XNZ A;  1M35 A;  2NQ6 A;  2EVM A;  5D6E A;  1W2M A;  2GU4 A;  4IKT A;  1R5H A;  1WL6 A;  5CIK A;  1YJ3 A;  3S6B A;  2OKN A;  1YW7 A;  2EA2 A;  1QXZ A;  2GA2 A;  4Z7M A;  1C22 A;  2BHC A;  2V3Z A;  1JAW A;  2Q95 A;  4EGE A;  2BHA A;  4FO7 A;  1A16 A;  4U6Z A;  5CDV A;  1B59 A;  1PV9 A;  1W7V A;  2GGC A;  2GZ5 A;  3FM3 A;  4KM3 A;  5CDL A;  1YW8 A;  5FCF A;  4OOK A;  4S01 A;  2GG3 A;  4A6W A;  5JFR A;  1YVM A;  4IU6 A;  4PNC A;  4QR8 A;  2NQ7 A;  2GG7 A;  4FKC A;  4IDY A;  3TAV A;  2BHD A;  4ZWO A;  1WN1 A;  3FMQ A;  3Q6D A;  1R5G A;  1C21 A;  4U1B A;  1WLR A;  3IU8 A;  1WL9 A;  4U76 A;  2Q8K A;  4U6W A;  3ROR A;  2GG9 A;  4S2R P;  4MAT A;  4U69 A;  1KP0 A;  2GTX A;  4B28 A;  2P98 A;  4RZY A;  3PKC A;  3PKE A;  1KQ0 A;  5JHU A;  1C27 A;  2GU6 A;  1O0X A;  2GG0 A;  2Q93 A;  4PV4 A;  2GU5 A;  1QXY A;  4A6V A;  4FLK A;  4JUQ A;  3CTZ A;  3L7G A;  4FLL A;  2MAT A;  3TB5 A;  2IW2 A;  4ZWU A;  2GG8 A;  1QZY A;  1C24 A;  2OAZ A;  4U75 A;  4IKR A;  4FO8 A;  4IKU A;  3IU7 A;  1XGM A;  1WKM A;  4S2T P;  2BWW A;  4IEC A;  4ZNG A;  1WBQ A;  2BWV A;  4HXX A;  3MAT A;  2EVO A;  2BWU A;  2Q94 A;  1XGO A;  2G6P A;  2BN7 A;  2GG5 A;  4ZWP A;  2V3Y A;  5CNX A;  4U6C A;  2BB7 A;  1WY2 A;  3PKA A;  1Y1N A;  4FUK A;  2BWS A;  1QXW A;  2B3L A;  4U70 A;  5CE6 A;  4IPA A;  2P99 A;  3CB5 A;  3BIQ A;  3IG4 A;  4U6J A;  2EA4 A;  5CDE A;  3MX6 A;  5JI6 A;  1BOA A;  3IU9 A;  2BWX A;  2V6C A;  2BWT A;  3RVA A;  3D27 A;  4FLJ A;  5D6F A;  4IF7 A;  1XGN A;  3FMR A;  2BWY A;  2GGB A;  1CHM A;  3BIP A;  2DFI A;  1KQ9 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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