2MATA

E.coli methionine aminopeptidase at 1.9 angstrom resolution
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords PROTEIN (METHIONINE AMINOPEPTIDASE)
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-03-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2matA00
1A16A 1C22A 1R5GA 1Y1NA 2GU5A 2BB7A 5CDVA 3PKDA 1W2MA 2B3LA 2GG5A 2GU6A 4OOKA 4FLLA 4KM3A 4RGZ1 2GGCA 4FO8A 1KP0A 1QXYA 2GU7A 4IF7A 1WL6A 2GG3A 2V3XA 5D6EA 2Q92A 5CDLA 2NQ7A 2OKNA 1BN5A 1WLRA 2HOWA 2GZ5A 1QXZA 4U73A 2NQ6A 2V6CA 1BOAA 4U6JA 1WKMA 2EA4A 2EVCA 2BWYA 2Q96A 2P99A 4S2RP 4S01A 4EGEA 4R60A 2BWXA 1C27A 4HXXA 1XGSA 3IG4A 4ZWOA 2ZSGA 3FMRA 4ZNGA 2OAZA 3MR1A 1YVMA 2V3ZA 3RVAA 1XNZA 2Q95A 3FMQA 4FLKA 5CDEA 2GA2A 1WL9A 4FLJA 2EA2A 4U6WA 2Q8KA 4U71A 3TAVA 2P98A 2B3HA 3Q6DA 5JI6A 2BWSA 2GG0A 3CB6A 4IECA 1CHMA 3L7GA 3BIQA 1C23A 2IW2A 3PKBA 1WY2A 4ZWPA 4FO7A 4U75A 4U1BA 2BHAA 2BWWA 1C21A 2G6PA 1YW8A 4S2TP 2P9AA 1B59A 1N51A 2GU4A 4Z7MA 2GG2A 4QR8A 4PV4A 2BHCA 2BWUA 3L24A 4IPAA 2MATA 2BWVA 5CLSA 2GG7A 1KQ9A 2BN7A 1MATA 3RORA 4A6VA 3CB5A 4FKCA 5CE6A 2EVMA 2BHDA 4IKSA 3PKCA 4RZYA 4RZZA 1M35A 3BITA 4U6ZA 3TB5A 2ADUA 4B28A 1YJ3A 5JHUA 5FCHA 1QZYA 4ZWUA 1YW9A 4FLIA 3PKAA 3PKEA 2EVOA 4S00A 1XGMA 2Q94A 3MX6A 4FUKA 5CIKA 4IKUA 2GTXA 5JFRA 1PV9A 1R58A 4IDYA 4IU6A 4PNCA 2GG9A 4MATA 1XGOA 1YW7A 2DFIA 1XGNA 4A6WA 1KQ0A 4U76A 1WBQA 3S6BA 1QXWA 2BH3A 3IU9A 3IU8A 4U70A 5E5BA 1JAWA 2Q93A 1WN1A 2V3YA 2GG8A 3IU7A 4JUQA 4U6EA 1R5HA 1B6AA 4U69A 3CTZA 5FCFA 1O0XA 4U6CA 3FM3A 5CNXA 1W7VA 2BHBA 2B3KA 3BIPA 3MATA 4IKRA 2GGBA 2BWTA 3D27A 4IKTA 1C24A 5D6FA
chains in the Genus database with same CATH superfamily
1A16A 1C22A 1R5GA 1Y1NA 2GU5A 2BB7A 5CDVA 3PKDA 1W2MA 2B3LA 2GG5A 2GU6A 4OOKA 4FLLA 4KM3A 4RGZ1 2GGCA 4FO8A 1KP0A 1QXYA 2GU7A 4IF7A 1WL6A 2GG3A 2V3XA 5D6EA 2Q92A 5CDLA 2NQ7A 2OKNA 1BN5A 1WLRA 2HOWA 2GZ5A 1QXZA 4U73A 2NQ6A 2V6CA 1BOAA 4U6JA 1WKMA 2EA4A 2EVCA 2BWYA 2Q96A 2P99A 4S2RP 4S01A 4EGEA 4R60A 2BWXA 1C27A 4HXXA 1XGSA 3IG4A 4ZWOA 2ZSGA 3FMRA 4ZNGA 2OAZA 3MR1A 1YVMA 2V3ZA 3RVAA 1XNZA 2Q95A 3FMQA 4FLKA 5CDEA 2GA2A 1WL9A 4FLJA 2EA2A 4U6WA 2Q8KA 4U71A 3TAVA 2P98A 2B3HA 3Q6DA 5JI6A 2BWSA 2GG0A 3CB6A 4IECA 1CHMA 3L7GA 3BIQA 1C23A 2IW2A 3PKBA 1WY2A 4ZWPA 4FO7A 4U75A 4U1BA 2BHAA 2BWWA 1C21A 2G6PA 1YW8A 4S2TP 2P9AA 1B59A 1N51A 2GU4A 4Z7MA 2GG2A 4QR8A 4PV4A 2BHCA 2BWUA 3L24A 4IPAA 2MATA 2BWVA 5CLSA 2GG7A 1KQ9A 2BN7A 1MATA 3RORA 4A6VA 3CB5A 4FKCA 5CE6A 2EVMA 2BHDA 4IKSA 3PKCA 4RZYA 4RZZA 1M35A 3BITA 4U6ZA 3TB5A 2ADUA 4B28A 1YJ3A 5JHUA 5FCHA 1QZYA 4ZWUA 1YW9A 4FLIA 3PKAA 3PKEA 2EVOA 4S00A 1XGMA 2Q94A 3MX6A 4FUKA 5CIKA 4IKUA 2GTXA 5JFRA 1PV9A 1R58A 4IDYA 4IU6A 4PNCA 2GG9A 4MATA 1XGOA 1YW7A 2DFIA 1XGNA 4A6WA 1KQ0A 4U76A 1WBQA 3S6BA 1QXWA 2BH3A 3IU9A 3IU8A 4U70A 5E5BA 1JAWA 2Q93A 1WN1A 2V3YA 2GG8A 3IU7A 4JUQA 4U6EA 1R5HA 1B6AA 4U69A 3CTZA 5FCFA 1O0XA 4U6CA 3FM3A 5CNXA 1W7VA 2BHBA 2B3KA 3BIPA 3MATA 4IKRA 2GGBA 2BWTA 3D27A 4IKTA 1C24A 5D6FA
chains in the Genus database with same CATH topology
1A16A 1C22A 1R5GA 1Y1NA 2GU5A 2BB7A 5CDVA 3PKDA 1W2MA 2B3LA 2GG5A 2GU6A 4OOKA 4FLLA 4KM3A 4RGZ1 2GGCA 4FO8A 1KP0A 1QXYA 2GU7A 4IF7A 1WL6A 2GG3A 2V3XA 5D6EA 2Q92A 5CDLA 2NQ7A 2OKNA 1BN5A 1WLRA 2HOWA 2GZ5A 1QXZA 4U73A 2NQ6A 2V6CA 1BOAA 4U6JA 1WKMA 2EA4A 2EVCA 2BWYA 2Q96A 2P99A 4S2RP 4S01A 4EGEA 4R60A 2BWXA 1C27A 4HXXA 1XGSA 3IG4A 4ZWOA 2ZSGA 3FMRA 4ZNGA 2OAZA 3MR1A 1YVMA 2V3ZA 3RVAA 1XNZA 2Q95A 3FMQA 4FLKA 5CDEA 2GA2A 1WL9A 4FLJA 2EA2A 4U6WA 2Q8KA 4U71A 3TAVA 2P98A 2B3HA 3Q6DA 5JI6A 2BWSA 2GG0A 3CB6A 4IECA 1CHMA 3L7GA 3BIQA 1C23A 2IW2A 3PKBA 1WY2A 4ZWPA 4FO7A 4U75A 4U1BA 2BHAA 2BWWA 1C21A 2G6PA 1YW8A 4S2TP 2P9AA 1B59A 1N51A 2GU4A 4Z7MA 2GG2A 4QR8A 4PV4A 2BHCA 2BWUA 3L24A 4IPAA 2MATA 2BWVA 5CLSA 2GG7A 1KQ9A 2BN7A 1MATA 3RORA 4A6VA 3CB5A 4FKCA 5CE6A 2EVMA 2BHDA 4IKSA 3PKCA 4RZYA 4RZZA 1M35A 3BITA 4U6ZA 3TB5A 2ADUA 4B28A 1YJ3A 5JHUA 5FCHA 1QZYA 4ZWUA 1YW9A 4FLIA 3PKAA 3PKEA 2EVOA 4S00A 1XGMA 2Q94A 3MX6A 4FUKA 5CIKA 4IKUA 2GTXA 5JFRA 1PV9A 1R58A 4IDYA 4IU6A 4PNCA 2GG9A 4MATA 1XGOA 1YW7A 2DFIA 1XGNA 4A6WA 1KQ0A 4U76A 1WBQA 3S6BA 1QXWA 2BH3A 3IU9A 3IU8A 4U70A 5E5BA 1JAWA 2Q93A 1WN1A 2V3YA 2GG8A 3IU7A 4JUQA 4U6EA 1R5HA 1B6AA 4U69A 3CTZA 5FCFA 1O0XA 4U6CA 3FM3A 5CNXA 1W7VA 2BHBA 2B3KA 3BIPA 3MATA 4IKRA 2GGBA 2BWTA 3D27A 4IKTA 1C24A 5D6FA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1A16 A;  1C22 A;  1R5G A;  1Y1N A;  2GU5 A;  2BB7 A;  5CDV A;  3PKD A;  1W2M A;  2B3L A;  2GG5 A;  2GU6 A;  4OOK A;  4FLL A;  4KM3 A;  4RGZ 1;  2GGC A;  4FO8 A;  1KP0 A;  1QXY A;  2GU7 A;  4IF7 A;  1WL6 A;  2GG3 A;  2V3X A;  5D6E A;  2Q92 A;  5CDL A;  2NQ7 A;  2OKN A;  1BN5 A;  1WLR A;  2HOW A;  2GZ5 A;  1QXZ A;  4U73 A;  2NQ6 A;  2V6C A;  1BOA A;  4U6J A;  1WKM A;  2EA4 A;  2EVC A;  2BWY A;  2Q96 A;  2P99 A;  4S2R P;  4S01 A;  4EGE A;  4R60 A;  2BWX A;  1C27 A;  4HXX A;  1XGS A;  3IG4 A;  4ZWO A;  2ZSG A;  3FMR A;  4ZNG A;  2OAZ A;  3MR1 A;  1YVM A;  2V3Z A;  3RVA A;  1XNZ A;  2Q95 A;  3FMQ A;  4FLK A;  5CDE A;  2GA2 A;  1WL9 A;  4FLJ A;  2EA2 A;  4U6W A;  2Q8K A;  4U71 A;  3TAV A;  2P98 A;  2B3H A;  3Q6D A;  5JI6 A;  2BWS A;  2GG0 A;  3CB6 A;  4IEC A;  1CHM A;  3L7G A;  3BIQ A;  1C23 A;  2IW2 A;  3PKB A;  1WY2 A;  4ZWP A;  4FO7 A;  4U75 A;  4U1B A;  2BHA A;  2BWW A;  1C21 A;  2G6P A;  1YW8 A;  4S2T P;  2P9A A;  1B59 A;  1N51 A;  2GU4 A;  4Z7M A;  2GG2 A;  4QR8 A;  4PV4 A;  2BHC A;  2BWU A;  3L24 A;  4IPA A;  2MAT A;  2BWV A;  5CLS A;  2GG7 A;  1KQ9 A;  2BN7 A;  1MAT A;  3ROR A;  4A6V A;  3CB5 A;  4FKC A;  5CE6 A;  2EVM A;  2BHD A;  4IKS A;  3PKC A;  4RZY A;  4RZZ A;  1M35 A;  3BIT A;  4U6Z A;  3TB5 A;  2ADU A;  4B28 A;  1YJ3 A;  5JHU A;  5FCH A;  1QZY A;  4ZWU A;  1YW9 A;  4FLI A;  3PKA A;  3PKE A;  2EVO A;  4S00 A;  1XGM A;  2Q94 A;  3MX6 A;  4FUK A;  5CIK A;  4IKU A;  2GTX A;  5JFR A;  1PV9 A;  1R58 A;  4IDY A;  4IU6 A;  4PNC A;  2GG9 A;  4MAT A;  1XGO A;  1YW7 A;  2DFI A;  1XGN A;  4A6W A;  1KQ0 A;  4U76 A;  1WBQ A;  3S6B A;  1QXW A;  2BH3 A;  3IU9 A;  3IU8 A;  4U70 A;  5E5B A;  1JAW A;  2Q93 A;  1WN1 A;  2V3Y A;  2GG8 A;  3IU7 A;  4JUQ A;  4U6E A;  1R5H A;  1B6A A;  4U69 A;  3CTZ A;  5FCF A;  1O0X A;  4U6C A;  3FM3 A;  5CNX A;  1W7V A;  2BHB A;  2B3K A;  3BIP A;  3MAT A;  4IKR A;  2GGB A;  2BWT A;  3D27 A;  4IKT A;  1C24 A;  5D6F A; 
#chains in the Genus database with same CATH topology
 1A16 A;  1C22 A;  1R5G A;  1Y1N A;  2GU5 A;  2BB7 A;  5CDV A;  3PKD A;  1W2M A;  2B3L A;  2GG5 A;  2GU6 A;  4OOK A;  4FLL A;  4KM3 A;  4RGZ 1;  2GGC A;  4FO8 A;  1KP0 A;  1QXY A;  2GU7 A;  4IF7 A;  1WL6 A;  2GG3 A;  2V3X A;  5D6E A;  2Q92 A;  5CDL A;  2NQ7 A;  2OKN A;  1BN5 A;  1WLR A;  2HOW A;  2GZ5 A;  1QXZ A;  4U73 A;  2NQ6 A;  2V6C A;  1BOA A;  4U6J A;  1WKM A;  2EA4 A;  2EVC A;  2BWY A;  2Q96 A;  2P99 A;  4S2R P;  4S01 A;  4EGE A;  4R60 A;  2BWX A;  1C27 A;  4HXX A;  1XGS A;  3IG4 A;  4ZWO A;  2ZSG A;  3FMR A;  4ZNG A;  2OAZ A;  3MR1 A;  1YVM A;  2V3Z A;  3RVA A;  1XNZ A;  2Q95 A;  3FMQ A;  4FLK A;  5CDE A;  2GA2 A;  1WL9 A;  4FLJ A;  2EA2 A;  4U6W A;  2Q8K A;  4U71 A;  3TAV A;  2P98 A;  2B3H A;  3Q6D A;  5JI6 A;  2BWS A;  2GG0 A;  3CB6 A;  4IEC A;  1CHM A;  3L7G A;  3BIQ A;  1C23 A;  2IW2 A;  3PKB A;  1WY2 A;  4ZWP A;  4FO7 A;  4U75 A;  4U1B A;  2BHA A;  2BWW A;  1C21 A;  2G6P A;  1YW8 A;  4S2T P;  2P9A A;  1B59 A;  1N51 A;  2GU4 A;  4Z7M A;  2GG2 A;  4QR8 A;  4PV4 A;  2BHC A;  2BWU A;  3L24 A;  4IPA A;  2MAT A;  2BWV A;  5CLS A;  2GG7 A;  1KQ9 A;  2BN7 A;  1MAT A;  3ROR A;  4A6V A;  3CB5 A;  4FKC A;  5CE6 A;  2EVM A;  2BHD A;  4IKS A;  3PKC A;  4RZY A;  4RZZ A;  1M35 A;  3BIT A;  4U6Z A;  3TB5 A;  2ADU A;  4B28 A;  1YJ3 A;  5JHU A;  5FCH A;  1QZY A;  4ZWU A;  1YW9 A;  4FLI A;  3PKA A;  3PKE A;  2EVO A;  4S00 A;  1XGM A;  2Q94 A;  3MX6 A;  4FUK A;  5CIK A;  4IKU A;  2GTX A;  5JFR A;  1PV9 A;  1R58 A;  4IDY A;  4IU6 A;  4PNC A;  2GG9 A;  4MAT A;  1XGO A;  1YW7 A;  2DFI A;  1XGN A;  4A6W A;  1KQ0 A;  4U76 A;  1WBQ A;  3S6B A;  1QXW A;  2BH3 A;  3IU9 A;  3IU8 A;  4U70 A;  5E5B A;  1JAW A;  2Q93 A;  1WN1 A;  2V3Y A;  2GG8 A;  3IU7 A;  4JUQ A;  4U6E A;  1R5H A;  1B6A A;  4U69 A;  3CTZ A;  5FCF A;  1O0X A;  4U6C A;  3FM3 A;  5CNX A;  1W7V A;  2BHB A;  2B3K A;  3BIP A;  3MAT A;  4IKR A;  2GGB A;  2BWT A;  3D27 A;  4IKT A;  1C24 A;  5D6F A; 
#chains in the Genus database with same CATH homology
 1A16 A;  1C22 A;  1R5G A;  1Y1N A;  2GU5 A;  2BB7 A;  5CDV A;  3PKD A;  1W2M A;  2B3L A;  2GG5 A;  2GU6 A;  4OOK A;  4FLL A;  4KM3 A;  4RGZ 1;  2GGC A;  4FO8 A;  1KP0 A;  1QXY A;  2GU7 A;  4IF7 A;  1WL6 A;  2GG3 A;  2V3X A;  5D6E A;  2Q92 A;  5CDL A;  2NQ7 A;  2OKN A;  1BN5 A;  1WLR A;  2HOW A;  2GZ5 A;  1QXZ A;  4U73 A;  2NQ6 A;  2V6C A;  1BOA A;  4U6J A;  1WKM A;  2EA4 A;  2EVC A;  2BWY A;  2Q96 A;  2P99 A;  4S2R P;  4S01 A;  4EGE A;  4R60 A;  2BWX A;  1C27 A;  4HXX A;  1XGS A;  3IG4 A;  4ZWO A;  2ZSG A;  3FMR A;  4ZNG A;  2OAZ A;  3MR1 A;  1YVM A;  2V3Z A;  3RVA A;  1XNZ A;  2Q95 A;  3FMQ A;  4FLK A;  5CDE A;  2GA2 A;  1WL9 A;  4FLJ A;  2EA2 A;  4U6W A;  2Q8K A;  4U71 A;  3TAV A;  2P98 A;  2B3H A;  3Q6D A;  5JI6 A;  2BWS A;  2GG0 A;  3CB6 A;  4IEC A;  1CHM A;  3L7G A;  3BIQ A;  1C23 A;  2IW2 A;  3PKB A;  1WY2 A;  4ZWP A;  4FO7 A;  4U75 A;  4U1B A;  2BHA A;  2BWW A;  1C21 A;  2G6P A;  1YW8 A;  4S2T P;  2P9A A;  1B59 A;  1N51 A;  2GU4 A;  4Z7M A;  2GG2 A;  4QR8 A;  4PV4 A;  2BHC A;  2BWU A;  3L24 A;  4IPA A;  2MAT A;  2BWV A;  5CLS A;  2GG7 A;  1KQ9 A;  2BN7 A;  1MAT A;  3ROR A;  4A6V A;  3CB5 A;  4FKC A;  5CE6 A;  2EVM A;  2BHD A;  4IKS A;  3PKC A;  4RZY A;  4RZZ A;  1M35 A;  3BIT A;  4U6Z A;  3TB5 A;  2ADU A;  4B28 A;  1YJ3 A;  5JHU A;  5FCH A;  1QZY A;  4ZWU A;  1YW9 A;  4FLI A;  3PKA A;  3PKE A;  2EVO A;  4S00 A;  1XGM A;  2Q94 A;  3MX6 A;  4FUK A;  5CIK A;  4IKU A;  2GTX A;  5JFR A;  1PV9 A;  1R58 A;  4IDY A;  4IU6 A;  4PNC A;  2GG9 A;  4MAT A;  1XGO A;  1YW7 A;  2DFI A;  1XGN A;  4A6W A;  1KQ0 A;  4U76 A;  1WBQ A;  3S6B A;  1QXW A;  2BH3 A;  3IU9 A;  3IU8 A;  4U70 A;  5E5B A;  1JAW A;  2Q93 A;  1WN1 A;  2V3Y A;  2GG8 A;  3IU7 A;  4JUQ A;  4U6E A;  1R5H A;  1B6A A;  4U69 A;  3CTZ A;  5FCF A;  1O0X A;  4U6C A;  3FM3 A;  5CNX A;  1W7V A;  2BHB A;  2B3K A;  3BIP A;  3MAT A;  4IKR A;  2GGB A;  2BWT A;  3D27 A;  4IKT A;  1C24 A;  5D6F A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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