2MATA

E.coli methionine aminopeptidase at 1.9 angstrom resolution
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords PROTEIN (METHIONINE AMINOPEPTIDASE)
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-03-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2matA00
4PV4A 1R58A 2BH3A 2DFIA 3PKCA 4FO7A 3TB5A 2P9AA 3RVAA 1QZYA 4KM3A 2Q8KA 2BHCA 1WBQA 5FCHA 4RZYA 2V3XA 5D6FA 4B28A 1XGSA 2EA2A 1O0XA 1WLRA 4ZNGA 2G6PA 2P99A 3IU9A 2Q94A 1WL6A 1MATA 3L7GA 2Q96A 5CE6A 5JFRA 4U76A 5CDLA 1YW9A 1XGNA 3FM3A 1XGMA 4RGZ1 1YW8A 4U6JA 2HOWA 2Q95A 1C27A 1B59A 1N51A 2BHBA 2NQ6A 2GGBA 2GU5A 3FMQA 4IPAA 2BWVA 2V3ZA 4U69A 1R5GA 3CB6A 1KQ9A 2B3LA 2GU7A 3BITA 1YJ3A 3PKDA 2IW2A 1PV9A 5CDEA 4EGEA 1WL9A 3RORA 1R5HA 4FLKA 4FUKA 4A6VA 2EA4A 2BHAA 4U6EA 1QXZA 2BN7A 1M35A 4U6WA 1JAWA 2BWYA 5FCFA 2GU4A 4U1BA 2BWTA 4IKUA 3IU8A 4FLJA 1KP0A 2EVCA 3CTZA 4IKRA 1C22A 2P98A 2B3HA 5JHUA 1YW7A 2GG9A 1QXYA 1Y1NA 2GG2A 2GG7A 3CB5A 1C23A 2Q93A 4JUQA 1KQ0A 4U6ZA 2BB7A 3BIPA 1XGOA 3PKEA 1XNZA 2ADUA 4RZZA 4U75A 3S6BA 3IU7A 3TAVA 1WY2A 3IG4A 3MATA 2BWUA 4IKSA 1W7VA 2GZ5A 4FO8A 4IKTA 4ZWPA 4QR8A 2V3YA 1CHMA 4OOKA 4S2TP 4FKCA 2GG8A 1C24A 2V6CA 4U71A 5CLSA 5E5BA 1WN1A 3Q6DA 3PKAA 4Z7MA 2ZSGA 4S01A 1BOAA 2BWSA 4A6WA 2GG0A 3BIQA 2OAZA 2GU6A 4MATA 4PNCA 2B3KA 4IU6A 4S2RP 2BWWA 4IECA 4ZWUA 3MR1A 2GGCA 2MATA 4R60A 4U70A 2BHDA 4HXXA 4ZWOA 2NQ7A 2GA2A 2GG3A 4IDYA 5CDVA 1BN5A 3D27A 2GG5A 2BWXA 2EVMA 1YVMA 3L24A 3PKBA 5JI6A 2Q92A 1B6AA 4S00A 4U6CA 1WKMA 1C21A 5D6EA 5CNXA 4FLLA 2GTXA 3MX6A 4FLIA 3FMRA 4IF7A 2EVOA 4U73A 1A16A 1QXWA 2OKNA 1W2MA 5CIKA
chains in the Genus database with same CATH superfamily
4PV4A 1R58A 2BH3A 2DFIA 3PKCA 4FO7A 3TB5A 2P9AA 3RVAA 1QZYA 4KM3A 2Q8KA 2BHCA 1WBQA 5FCHA 4RZYA 2V3XA 5D6FA 4B28A 1XGSA 2EA2A 1O0XA 1WLRA 4ZNGA 2G6PA 2P99A 3IU9A 2Q94A 1WL6A 1MATA 3L7GA 2Q96A 5CE6A 5JFRA 4U76A 5CDLA 1YW9A 1XGNA 3FM3A 1XGMA 4RGZ1 1YW8A 4U6JA 2HOWA 2Q95A 1C27A 1B59A 1N51A 2BHBA 2NQ6A 2GGBA 2GU5A 3FMQA 4IPAA 2BWVA 2V3ZA 4U69A 1R5GA 3CB6A 1KQ9A 2B3LA 2GU7A 3BITA 1YJ3A 3PKDA 2IW2A 1PV9A 5CDEA 4EGEA 1WL9A 3RORA 1R5HA 4FLKA 4FUKA 4A6VA 2EA4A 2BHAA 4U6EA 1QXZA 2BN7A 1M35A 4U6WA 1JAWA 2BWYA 5FCFA 2GU4A 4U1BA 2BWTA 4IKUA 3IU8A 4FLJA 1KP0A 2EVCA 3CTZA 4IKRA 1C22A 2P98A 2B3HA 5JHUA 1YW7A 2GG9A 1QXYA 1Y1NA 2GG2A 2GG7A 3CB5A 1C23A 2Q93A 4JUQA 1KQ0A 4U6ZA 2BB7A 3BIPA 1XGOA 3PKEA 1XNZA 2ADUA 4RZZA 4U75A 3S6BA 3IU7A 3TAVA 1WY2A 3IG4A 3MATA 2BWUA 4IKSA 1W7VA 2GZ5A 4FO8A 4IKTA 4ZWPA 4QR8A 2V3YA 1CHMA 4OOKA 4S2TP 4FKCA 2GG8A 1C24A 2V6CA 4U71A 5CLSA 5E5BA 1WN1A 3Q6DA 3PKAA 4Z7MA 2ZSGA 4S01A 1BOAA 2BWSA 4A6WA 2GG0A 3BIQA 2OAZA 2GU6A 4MATA 4PNCA 2B3KA 4IU6A 4S2RP 2BWWA 4IECA 4ZWUA 3MR1A 2GGCA 2MATA 4R60A 4U70A 2BHDA 4HXXA 4ZWOA 2NQ7A 2GA2A 2GG3A 4IDYA 5CDVA 1BN5A 3D27A 2GG5A 2BWXA 2EVMA 1YVMA 3L24A 3PKBA 5JI6A 2Q92A 1B6AA 4S00A 4U6CA 1WKMA 1C21A 5D6EA 5CNXA 4FLLA 2GTXA 3MX6A 4FLIA 3FMRA 4IF7A 2EVOA 4U73A 1A16A 1QXWA 2OKNA 1W2MA 5CIKA
chains in the Genus database with same CATH topology
4PV4A 1R58A 2BH3A 2DFIA 3PKCA 4FO7A 3TB5A 2P9AA 3RVAA 1QZYA 4KM3A 2Q8KA 2BHCA 1WBQA 5FCHA 4RZYA 2V3XA 5D6FA 4B28A 1XGSA 2EA2A 1O0XA 1WLRA 4ZNGA 2G6PA 2P99A 3IU9A 2Q94A 1WL6A 1MATA 3L7GA 2Q96A 5CE6A 5JFRA 4U76A 5CDLA 1YW9A 1XGNA 3FM3A 1XGMA 4RGZ1 1YW8A 4U6JA 2HOWA 2Q95A 1C27A 1B59A 1N51A 2BHBA 2NQ6A 2GGBA 2GU5A 3FMQA 4IPAA 2BWVA 2V3ZA 4U69A 1R5GA 3CB6A 1KQ9A 2B3LA 2GU7A 3BITA 1YJ3A 3PKDA 2IW2A 1PV9A 5CDEA 4EGEA 1WL9A 3RORA 1R5HA 4FLKA 4FUKA 4A6VA 2EA4A 2BHAA 4U6EA 1QXZA 2BN7A 1M35A 4U6WA 1JAWA 2BWYA 5FCFA 2GU4A 4U1BA 2BWTA 4IKUA 3IU8A 4FLJA 1KP0A 2EVCA 3CTZA 4IKRA 1C22A 2P98A 2B3HA 5JHUA 1YW7A 2GG9A 1QXYA 1Y1NA 2GG2A 2GG7A 3CB5A 1C23A 2Q93A 4JUQA 1KQ0A 4U6ZA 2BB7A 3BIPA 1XGOA 3PKEA 1XNZA 2ADUA 4RZZA 4U75A 3S6BA 3IU7A 3TAVA 1WY2A 3IG4A 3MATA 2BWUA 4IKSA 1W7VA 2GZ5A 4FO8A 4IKTA 4ZWPA 4QR8A 2V3YA 1CHMA 4OOKA 4S2TP 4FKCA 2GG8A 1C24A 2V6CA 4U71A 5CLSA 5E5BA 1WN1A 3Q6DA 3PKAA 4Z7MA 2ZSGA 4S01A 1BOAA 2BWSA 4A6WA 2GG0A 3BIQA 2OAZA 2GU6A 4MATA 4PNCA 2B3KA 4IU6A 4S2RP 2BWWA 4IECA 4ZWUA 3MR1A 2GGCA 2MATA 4R60A 4U70A 2BHDA 4HXXA 4ZWOA 2NQ7A 2GA2A 2GG3A 4IDYA 5CDVA 1BN5A 3D27A 2GG5A 2BWXA 2EVMA 1YVMA 3L24A 3PKBA 5JI6A 2Q92A 1B6AA 4S00A 4U6CA 1WKMA 1C21A 5D6EA 5CNXA 4FLLA 2GTXA 3MX6A 4FLIA 3FMRA 4IF7A 2EVOA 4U73A 1A16A 1QXWA 2OKNA 1W2MA 5CIKA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4PV4 A;  1R58 A;  2BH3 A;  2DFI A;  3PKC A;  4FO7 A;  3TB5 A;  2P9A A;  3RVA A;  1QZY A;  4KM3 A;  2Q8K A;  2BHC A;  1WBQ A;  5FCH A;  4RZY A;  2V3X A;  5D6F A;  4B28 A;  1XGS A;  2EA2 A;  1O0X A;  1WLR A;  4ZNG A;  2G6P A;  2P99 A;  3IU9 A;  2Q94 A;  1WL6 A;  1MAT A;  3L7G A;  2Q96 A;  5CE6 A;  5JFR A;  4U76 A;  5CDL A;  1YW9 A;  1XGN A;  3FM3 A;  1XGM A;  4RGZ 1;  1YW8 A;  4U6J A;  2HOW A;  2Q95 A;  1C27 A;  1B59 A;  1N51 A;  2BHB A;  2NQ6 A;  2GGB A;  2GU5 A;  3FMQ A;  4IPA A;  2BWV A;  2V3Z A;  4U69 A;  1R5G A;  3CB6 A;  1KQ9 A;  2B3L A;  2GU7 A;  3BIT A;  1YJ3 A;  3PKD A;  2IW2 A;  1PV9 A;  5CDE A;  4EGE A;  1WL9 A;  3ROR A;  1R5H A;  4FLK A;  4FUK A;  4A6V A;  2EA4 A;  2BHA A;  4U6E A;  1QXZ A;  2BN7 A;  1M35 A;  4U6W A;  1JAW A;  2BWY A;  5FCF A;  2GU4 A;  4U1B A;  2BWT A;  4IKU A;  3IU8 A;  4FLJ A;  1KP0 A;  2EVC A;  3CTZ A;  4IKR A;  1C22 A;  2P98 A;  2B3H A;  5JHU A;  1YW7 A;  2GG9 A;  1QXY A;  1Y1N A;  2GG2 A;  2GG7 A;  3CB5 A;  1C23 A;  2Q93 A;  4JUQ A;  1KQ0 A;  4U6Z A;  2BB7 A;  3BIP A;  1XGO A;  3PKE A;  1XNZ A;  2ADU A;  4RZZ A;  4U75 A;  3S6B A;  3IU7 A;  3TAV A;  1WY2 A;  3IG4 A;  3MAT A;  2BWU A;  4IKS A;  1W7V A;  2GZ5 A;  4FO8 A;  4IKT A;  4ZWP A;  4QR8 A;  2V3Y A;  1CHM A;  4OOK A;  4S2T P;  4FKC A;  2GG8 A;  1C24 A;  2V6C A;  4U71 A;  5CLS A;  5E5B A;  1WN1 A;  3Q6D A;  3PKA A;  4Z7M A;  2ZSG A;  4S01 A;  1BOA A;  2BWS A;  4A6W A;  2GG0 A;  3BIQ A;  2OAZ A;  2GU6 A;  4MAT A;  4PNC A;  2B3K A;  4IU6 A;  4S2R P;  2BWW A;  4IEC A;  4ZWU A;  3MR1 A;  2GGC A;  2MAT A;  4R60 A;  4U70 A;  2BHD A;  4HXX A;  4ZWO A;  2NQ7 A;  2GA2 A;  2GG3 A;  4IDY A;  5CDV A;  1BN5 A;  3D27 A;  2GG5 A;  2BWX A;  2EVM A;  1YVM A;  3L24 A;  3PKB A;  5JI6 A;  2Q92 A;  1B6A A;  4S00 A;  4U6C A;  1WKM A;  1C21 A;  5D6E A;  5CNX A;  4FLL A;  2GTX A;  3MX6 A;  4FLI A;  3FMR A;  4IF7 A;  2EVO A;  4U73 A;  1A16 A;  1QXW A;  2OKN A;  1W2M A;  5CIK A; 
#chains in the Genus database with same CATH topology
 4PV4 A;  1R58 A;  2BH3 A;  2DFI A;  3PKC A;  4FO7 A;  3TB5 A;  2P9A A;  3RVA A;  1QZY A;  4KM3 A;  2Q8K A;  2BHC A;  1WBQ A;  5FCH A;  4RZY A;  2V3X A;  5D6F A;  4B28 A;  1XGS A;  2EA2 A;  1O0X A;  1WLR A;  4ZNG A;  2G6P A;  2P99 A;  3IU9 A;  2Q94 A;  1WL6 A;  1MAT A;  3L7G A;  2Q96 A;  5CE6 A;  5JFR A;  4U76 A;  5CDL A;  1YW9 A;  1XGN A;  3FM3 A;  1XGM A;  4RGZ 1;  1YW8 A;  4U6J A;  2HOW A;  2Q95 A;  1C27 A;  1B59 A;  1N51 A;  2BHB A;  2NQ6 A;  2GGB A;  2GU5 A;  3FMQ A;  4IPA A;  2BWV A;  2V3Z A;  4U69 A;  1R5G A;  3CB6 A;  1KQ9 A;  2B3L A;  2GU7 A;  3BIT A;  1YJ3 A;  3PKD A;  2IW2 A;  1PV9 A;  5CDE A;  4EGE A;  1WL9 A;  3ROR A;  1R5H A;  4FLK A;  4FUK A;  4A6V A;  2EA4 A;  2BHA A;  4U6E A;  1QXZ A;  2BN7 A;  1M35 A;  4U6W A;  1JAW A;  2BWY A;  5FCF A;  2GU4 A;  4U1B A;  2BWT A;  4IKU A;  3IU8 A;  4FLJ A;  1KP0 A;  2EVC A;  3CTZ A;  4IKR A;  1C22 A;  2P98 A;  2B3H A;  5JHU A;  1YW7 A;  2GG9 A;  1QXY A;  1Y1N A;  2GG2 A;  2GG7 A;  3CB5 A;  1C23 A;  2Q93 A;  4JUQ A;  1KQ0 A;  4U6Z A;  2BB7 A;  3BIP A;  1XGO A;  3PKE A;  1XNZ A;  2ADU A;  4RZZ A;  4U75 A;  3S6B A;  3IU7 A;  3TAV A;  1WY2 A;  3IG4 A;  3MAT A;  2BWU A;  4IKS A;  1W7V A;  2GZ5 A;  4FO8 A;  4IKT A;  4ZWP A;  4QR8 A;  2V3Y A;  1CHM A;  4OOK A;  4S2T P;  4FKC A;  2GG8 A;  1C24 A;  2V6C A;  4U71 A;  5CLS A;  5E5B A;  1WN1 A;  3Q6D A;  3PKA A;  4Z7M A;  2ZSG A;  4S01 A;  1BOA A;  2BWS A;  4A6W A;  2GG0 A;  3BIQ A;  2OAZ A;  2GU6 A;  4MAT A;  4PNC A;  2B3K A;  4IU6 A;  4S2R P;  2BWW A;  4IEC A;  4ZWU A;  3MR1 A;  2GGC A;  2MAT A;  4R60 A;  4U70 A;  2BHD A;  4HXX A;  4ZWO A;  2NQ7 A;  2GA2 A;  2GG3 A;  4IDY A;  5CDV A;  1BN5 A;  3D27 A;  2GG5 A;  2BWX A;  2EVM A;  1YVM A;  3L24 A;  3PKB A;  5JI6 A;  2Q92 A;  1B6A A;  4S00 A;  4U6C A;  1WKM A;  1C21 A;  5D6E A;  5CNX A;  4FLL A;  2GTX A;  3MX6 A;  4FLI A;  3FMR A;  4IF7 A;  2EVO A;  4U73 A;  1A16 A;  1QXW A;  2OKN A;  1W2M A;  5CIK A; 
#chains in the Genus database with same CATH homology
 4PV4 A;  1R58 A;  2BH3 A;  2DFI A;  3PKC A;  4FO7 A;  3TB5 A;  2P9A A;  3RVA A;  1QZY A;  4KM3 A;  2Q8K A;  2BHC A;  1WBQ A;  5FCH A;  4RZY A;  2V3X A;  5D6F A;  4B28 A;  1XGS A;  2EA2 A;  1O0X A;  1WLR A;  4ZNG A;  2G6P A;  2P99 A;  3IU9 A;  2Q94 A;  1WL6 A;  1MAT A;  3L7G A;  2Q96 A;  5CE6 A;  5JFR A;  4U76 A;  5CDL A;  1YW9 A;  1XGN A;  3FM3 A;  1XGM A;  4RGZ 1;  1YW8 A;  4U6J A;  2HOW A;  2Q95 A;  1C27 A;  1B59 A;  1N51 A;  2BHB A;  2NQ6 A;  2GGB A;  2GU5 A;  3FMQ A;  4IPA A;  2BWV A;  2V3Z A;  4U69 A;  1R5G A;  3CB6 A;  1KQ9 A;  2B3L A;  2GU7 A;  3BIT A;  1YJ3 A;  3PKD A;  2IW2 A;  1PV9 A;  5CDE A;  4EGE A;  1WL9 A;  3ROR A;  1R5H A;  4FLK A;  4FUK A;  4A6V A;  2EA4 A;  2BHA A;  4U6E A;  1QXZ A;  2BN7 A;  1M35 A;  4U6W A;  1JAW A;  2BWY A;  5FCF A;  2GU4 A;  4U1B A;  2BWT A;  4IKU A;  3IU8 A;  4FLJ A;  1KP0 A;  2EVC A;  3CTZ A;  4IKR A;  1C22 A;  2P98 A;  2B3H A;  5JHU A;  1YW7 A;  2GG9 A;  1QXY A;  1Y1N A;  2GG2 A;  2GG7 A;  3CB5 A;  1C23 A;  2Q93 A;  4JUQ A;  1KQ0 A;  4U6Z A;  2BB7 A;  3BIP A;  1XGO A;  3PKE A;  1XNZ A;  2ADU A;  4RZZ A;  4U75 A;  3S6B A;  3IU7 A;  3TAV A;  1WY2 A;  3IG4 A;  3MAT A;  2BWU A;  4IKS A;  1W7V A;  2GZ5 A;  4FO8 A;  4IKT A;  4ZWP A;  4QR8 A;  2V3Y A;  1CHM A;  4OOK A;  4S2T P;  4FKC A;  2GG8 A;  1C24 A;  2V6C A;  4U71 A;  5CLS A;  5E5B A;  1WN1 A;  3Q6D A;  3PKA A;  4Z7M A;  2ZSG A;  4S01 A;  1BOA A;  2BWS A;  4A6W A;  2GG0 A;  3BIQ A;  2OAZ A;  2GU6 A;  4MAT A;  4PNC A;  2B3K A;  4IU6 A;  4S2R P;  2BWW A;  4IEC A;  4ZWU A;  3MR1 A;  2GGC A;  2MAT A;  4R60 A;  4U70 A;  2BHD A;  4HXX A;  4ZWO A;  2NQ7 A;  2GA2 A;  2GG3 A;  4IDY A;  5CDV A;  1BN5 A;  3D27 A;  2GG5 A;  2BWX A;  2EVM A;  1YVM A;  3L24 A;  3PKB A;  5JI6 A;  2Q92 A;  1B6A A;  4S00 A;  4U6C A;  1WKM A;  1C21 A;  5D6E A;  5CNX A;  4FLL A;  2GTX A;  3MX6 A;  4FLI A;  3FMR A;  4IF7 A;  2EVO A;  4U73 A;  1A16 A;  1QXW A;  2OKN A;  1W2M A;  5CIK A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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