2NQ6A

Crystal structure of human methionine aminopeptidase type 1 in complex with 3-tert-butoxycarbonylaminopyridine-2-carboxylic acid thiazole-2-ylamide
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2nq6A00
1C21A 2B3HA 2V3XA 1WY2A 2HOWA 4PV4A 4S2RP 4ZWUA 3PKDA 4FO8A 4Z7MA 1O0XA 1M35A 1KQ0A 1Y1NA 4FKCA 2OKNA 3PKEA 1YW8A 2EVCA 1WN1A 1B6AA 2GG0A 4MATA 4R60A 1PV9A 2EA4A 4PNCA 4B28A 4U75A 3BITA 2Q92A 3D27A 1CHMA 5JI6A 3L7GA 1YVMA 2EVOA 3IU7A 2BN7A 2Q95A 1KP0A 1MATA 4IECA 1BOAA 2GA2A 4JUQA 4RZZA 2Q96A 4U6WA 2BWWA 4HXXA 2BWTA 4ZNGA 5FCHA 3RVAA 1C27A 1W7VA 2NQ6A 2BWUA 2BB7A 3BIQA 3IU9A 3MATA 5CNXA 2Q93A 1WLRA 1WKMA 2BHAA 5CDEA 3MR1A 4A6WA 2V6CA 4IKTA 1XGMA 1YJ3A 2V3YA 4IU6A 5CLSA 1B59A 1R5GA 2BWYA 2GG7A 2GZ5A 4S00A 3CB5A 3FMQA 1XGSA 3S6BA 1C24A 5CIKA 4FLKA 2BH3A 2NQ7A 1C22A 2ADUA 2EVMA 1KQ9A 4IKSA 2GU6A 5JFRA 4RGZ1 5CE6A 4U6JA 4FUKA 2Q8KA 5E5BA 1A16A 4FO7A 4U6ZA 2GG9A 4U1BA 2G6PA 1R58A 2GGCA 2P99A 1R5HA 3PKAA 4RZYA 1WL6A 1QXZA 2BHBA 2BWXA 4FLIA 3MX6A 4FLLA 2B3LA 4ZWPA 4U6CA 2GGBA 4U69A 3IG4A 2GU4A 5D6FA 4S2TP 2BWVA 2BHCA 4IF7A 2BWSA 1N51A 3RORA 1XNZA 4S01A 1XGNA 3IU8A 4U76A 1YW7A 2GG3A 2GG2A 2DFIA 4U73A 3PKBA 4EGEA 5CDLA 4QR8A 1QXYA 1WL9A 2GG5A 2GU7A 4OOKA 4U71A 2V3ZA 3PKCA 4IKUA 3TB5A 5CDVA 1BN5A 1JAWA 3FMRA 4ZWOA 1W2MA 2P98A 5D6EA 2BHDA 5JHUA 4A6VA 2B3KA 2GTXA 5FCFA 4U6EA 4U70A 2P9AA 4IDYA 2GU5A 1QXWA 1YW9A 4IKRA 2EA2A 3CTZA 3Q6DA 3L24A 1C23A 3BIPA 1QZYA 2ZSGA 4KM3A 3TAVA 2Q94A 1XGOA 3CB6A 2IW2A 3FM3A 1WBQA 4IPAA 4FLJA 2MATA 2OAZA 2GG8A
chains in the Genus database with same CATH superfamily
1C21A 2B3HA 2V3XA 1WY2A 2HOWA 4PV4A 4S2RP 4ZWUA 3PKDA 4FO8A 4Z7MA 1O0XA 1M35A 1KQ0A 1Y1NA 4FKCA 2OKNA 3PKEA 1YW8A 2EVCA 1WN1A 1B6AA 2GG0A 4MATA 4R60A 1PV9A 2EA4A 4PNCA 4B28A 4U75A 3BITA 2Q92A 3D27A 1CHMA 5JI6A 3L7GA 1YVMA 2EVOA 3IU7A 2BN7A 2Q95A 1KP0A 1MATA 4IECA 1BOAA 2GA2A 4JUQA 4RZZA 2Q96A 4U6WA 2BWWA 4HXXA 2BWTA 4ZNGA 5FCHA 3RVAA 1C27A 1W7VA 2NQ6A 2BWUA 2BB7A 3BIQA 3IU9A 3MATA 5CNXA 2Q93A 1WLRA 1WKMA 2BHAA 5CDEA 3MR1A 4A6WA 2V6CA 4IKTA 1XGMA 1YJ3A 2V3YA 4IU6A 5CLSA 1B59A 1R5GA 2BWYA 2GG7A 2GZ5A 4S00A 3CB5A 3FMQA 1XGSA 3S6BA 1C24A 5CIKA 4FLKA 2BH3A 2NQ7A 1C22A 2ADUA 2EVMA 1KQ9A 4IKSA 2GU6A 5JFRA 4RGZ1 5CE6A 4U6JA 4FUKA 2Q8KA 5E5BA 1A16A 4FO7A 4U6ZA 2GG9A 4U1BA 2G6PA 1R58A 2GGCA 2P99A 1R5HA 3PKAA 4RZYA 1WL6A 1QXZA 2BHBA 2BWXA 4FLIA 3MX6A 4FLLA 2B3LA 4ZWPA 4U6CA 2GGBA 4U69A 3IG4A 2GU4A 5D6FA 4S2TP 2BWVA 2BHCA 4IF7A 2BWSA 1N51A 3RORA 1XNZA 4S01A 1XGNA 3IU8A 4U76A 1YW7A 2GG3A 2GG2A 2DFIA 4U73A 3PKBA 4EGEA 5CDLA 4QR8A 1QXYA 1WL9A 2GG5A 2GU7A 4OOKA 4U71A 2V3ZA 3PKCA 4IKUA 3TB5A 5CDVA 1BN5A 1JAWA 3FMRA 4ZWOA 1W2MA 2P98A 5D6EA 2BHDA 5JHUA 4A6VA 2B3KA 2GTXA 5FCFA 4U6EA 4U70A 2P9AA 4IDYA 2GU5A 1QXWA 1YW9A 4IKRA 2EA2A 3CTZA 3Q6DA 3L24A 1C23A 3BIPA 1QZYA 2ZSGA 4KM3A 3TAVA 2Q94A 1XGOA 3CB6A 2IW2A 3FM3A 1WBQA 4IPAA 4FLJA 2MATA 2OAZA 2GG8A
chains in the Genus database with same CATH topology
1C21A 2B3HA 2V3XA 1WY2A 2HOWA 4PV4A 4S2RP 4ZWUA 3PKDA 4FO8A 4Z7MA 1O0XA 1M35A 1KQ0A 1Y1NA 4FKCA 2OKNA 3PKEA 1YW8A 2EVCA 1WN1A 1B6AA 2GG0A 4MATA 4R60A 1PV9A 2EA4A 4PNCA 4B28A 4U75A 3BITA 2Q92A 3D27A 1CHMA 5JI6A 3L7GA 1YVMA 2EVOA 3IU7A 2BN7A 2Q95A 1KP0A 1MATA 4IECA 1BOAA 2GA2A 4JUQA 4RZZA 2Q96A 4U6WA 2BWWA 4HXXA 2BWTA 4ZNGA 5FCHA 3RVAA 1C27A 1W7VA 2NQ6A 2BWUA 2BB7A 3BIQA 3IU9A 3MATA 5CNXA 2Q93A 1WLRA 1WKMA 2BHAA 5CDEA 3MR1A 4A6WA 2V6CA 4IKTA 1XGMA 1YJ3A 2V3YA 4IU6A 5CLSA 1B59A 1R5GA 2BWYA 2GG7A 2GZ5A 4S00A 3CB5A 3FMQA 1XGSA 3S6BA 1C24A 5CIKA 4FLKA 2BH3A 2NQ7A 1C22A 2ADUA 2EVMA 1KQ9A 4IKSA 2GU6A 5JFRA 4RGZ1 5CE6A 4U6JA 4FUKA 2Q8KA 5E5BA 1A16A 4FO7A 4U6ZA 2GG9A 4U1BA 2G6PA 1R58A 2GGCA 2P99A 1R5HA 3PKAA 4RZYA 1WL6A 1QXZA 2BHBA 2BWXA 4FLIA 3MX6A 4FLLA 2B3LA 4ZWPA 4U6CA 2GGBA 4U69A 3IG4A 2GU4A 5D6FA 4S2TP 2BWVA 2BHCA 4IF7A 2BWSA 1N51A 3RORA 1XNZA 4S01A 1XGNA 3IU8A 4U76A 1YW7A 2GG3A 2GG2A 2DFIA 4U73A 3PKBA 4EGEA 5CDLA 4QR8A 1QXYA 1WL9A 2GG5A 2GU7A 4OOKA 4U71A 2V3ZA 3PKCA 4IKUA 3TB5A 5CDVA 1BN5A 1JAWA 3FMRA 4ZWOA 1W2MA 2P98A 5D6EA 2BHDA 5JHUA 4A6VA 2B3KA 2GTXA 5FCFA 4U6EA 4U70A 2P9AA 4IDYA 2GU5A 1QXWA 1YW9A 4IKRA 2EA2A 3CTZA 3Q6DA 3L24A 1C23A 3BIPA 1QZYA 2ZSGA 4KM3A 3TAVA 2Q94A 1XGOA 3CB6A 2IW2A 3FM3A 1WBQA 4IPAA 4FLJA 2MATA 2OAZA 2GG8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1C21 A;  2B3H A;  2V3X A;  1WY2 A;  2HOW A;  4PV4 A;  4S2R P;  4ZWU A;  3PKD A;  4FO8 A;  4Z7M A;  1O0X A;  1M35 A;  1KQ0 A;  1Y1N A;  4FKC A;  2OKN A;  3PKE A;  1YW8 A;  2EVC A;  1WN1 A;  1B6A A;  2GG0 A;  4MAT A;  4R60 A;  1PV9 A;  2EA4 A;  4PNC A;  4B28 A;  4U75 A;  3BIT A;  2Q92 A;  3D27 A;  1CHM A;  5JI6 A;  3L7G A;  1YVM A;  2EVO A;  3IU7 A;  2BN7 A;  2Q95 A;  1KP0 A;  1MAT A;  4IEC A;  1BOA A;  2GA2 A;  4JUQ A;  4RZZ A;  2Q96 A;  4U6W A;  2BWW A;  4HXX A;  2BWT A;  4ZNG A;  5FCH A;  3RVA A;  1C27 A;  1W7V A;  2NQ6 A;  2BWU A;  2BB7 A;  3BIQ A;  3IU9 A;  3MAT A;  5CNX A;  2Q93 A;  1WLR A;  1WKM A;  2BHA A;  5CDE A;  3MR1 A;  4A6W A;  2V6C A;  4IKT A;  1XGM A;  1YJ3 A;  2V3Y A;  4IU6 A;  5CLS A;  1B59 A;  1R5G A;  2BWY A;  2GG7 A;  2GZ5 A;  4S00 A;  3CB5 A;  3FMQ A;  1XGS A;  3S6B A;  1C24 A;  5CIK A;  4FLK A;  2BH3 A;  2NQ7 A;  1C22 A;  2ADU A;  2EVM A;  1KQ9 A;  4IKS A;  2GU6 A;  5JFR A;  4RGZ 1;  5CE6 A;  4U6J A;  4FUK A;  2Q8K A;  5E5B A;  1A16 A;  4FO7 A;  4U6Z A;  2GG9 A;  4U1B A;  2G6P A;  1R58 A;  2GGC A;  2P99 A;  1R5H A;  3PKA A;  4RZY A;  1WL6 A;  1QXZ A;  2BHB A;  2BWX A;  4FLI A;  3MX6 A;  4FLL A;  2B3L A;  4ZWP A;  4U6C A;  2GGB A;  4U69 A;  3IG4 A;  2GU4 A;  5D6F A;  4S2T P;  2BWV A;  2BHC A;  4IF7 A;  2BWS A;  1N51 A;  3ROR A;  1XNZ A;  4S01 A;  1XGN A;  3IU8 A;  4U76 A;  1YW7 A;  2GG3 A;  2GG2 A;  2DFI A;  4U73 A;  3PKB A;  4EGE A;  5CDL A;  4QR8 A;  1QXY A;  1WL9 A;  2GG5 A;  2GU7 A;  4OOK A;  4U71 A;  2V3Z A;  3PKC A;  4IKU A;  3TB5 A;  5CDV A;  1BN5 A;  1JAW A;  3FMR A;  4ZWO A;  1W2M A;  2P98 A;  5D6E A;  2BHD A;  5JHU A;  4A6V A;  2B3K A;  2GTX A;  5FCF A;  4U6E A;  4U70 A;  2P9A A;  4IDY A;  2GU5 A;  1QXW A;  1YW9 A;  4IKR A;  2EA2 A;  3CTZ A;  3Q6D A;  3L24 A;  1C23 A;  3BIP A;  1QZY A;  2ZSG A;  4KM3 A;  3TAV A;  2Q94 A;  1XGO A;  3CB6 A;  2IW2 A;  3FM3 A;  1WBQ A;  4IPA A;  4FLJ A;  2MAT A;  2OAZ A;  2GG8 A; 
#chains in the Genus database with same CATH topology
 1C21 A;  2B3H A;  2V3X A;  1WY2 A;  2HOW A;  4PV4 A;  4S2R P;  4ZWU A;  3PKD A;  4FO8 A;  4Z7M A;  1O0X A;  1M35 A;  1KQ0 A;  1Y1N A;  4FKC A;  2OKN A;  3PKE A;  1YW8 A;  2EVC A;  1WN1 A;  1B6A A;  2GG0 A;  4MAT A;  4R60 A;  1PV9 A;  2EA4 A;  4PNC A;  4B28 A;  4U75 A;  3BIT A;  2Q92 A;  3D27 A;  1CHM A;  5JI6 A;  3L7G A;  1YVM A;  2EVO A;  3IU7 A;  2BN7 A;  2Q95 A;  1KP0 A;  1MAT A;  4IEC A;  1BOA A;  2GA2 A;  4JUQ A;  4RZZ A;  2Q96 A;  4U6W A;  2BWW A;  4HXX A;  2BWT A;  4ZNG A;  5FCH A;  3RVA A;  1C27 A;  1W7V A;  2NQ6 A;  2BWU A;  2BB7 A;  3BIQ A;  3IU9 A;  3MAT A;  5CNX A;  2Q93 A;  1WLR A;  1WKM A;  2BHA A;  5CDE A;  3MR1 A;  4A6W A;  2V6C A;  4IKT A;  1XGM A;  1YJ3 A;  2V3Y A;  4IU6 A;  5CLS A;  1B59 A;  1R5G A;  2BWY A;  2GG7 A;  2GZ5 A;  4S00 A;  3CB5 A;  3FMQ A;  1XGS A;  3S6B A;  1C24 A;  5CIK A;  4FLK A;  2BH3 A;  2NQ7 A;  1C22 A;  2ADU A;  2EVM A;  1KQ9 A;  4IKS A;  2GU6 A;  5JFR A;  4RGZ 1;  5CE6 A;  4U6J A;  4FUK A;  2Q8K A;  5E5B A;  1A16 A;  4FO7 A;  4U6Z A;  2GG9 A;  4U1B A;  2G6P A;  1R58 A;  2GGC A;  2P99 A;  1R5H A;  3PKA A;  4RZY A;  1WL6 A;  1QXZ A;  2BHB A;  2BWX A;  4FLI A;  3MX6 A;  4FLL A;  2B3L A;  4ZWP A;  4U6C A;  2GGB A;  4U69 A;  3IG4 A;  2GU4 A;  5D6F A;  4S2T P;  2BWV A;  2BHC A;  4IF7 A;  2BWS A;  1N51 A;  3ROR A;  1XNZ A;  4S01 A;  1XGN A;  3IU8 A;  4U76 A;  1YW7 A;  2GG3 A;  2GG2 A;  2DFI A;  4U73 A;  3PKB A;  4EGE A;  5CDL A;  4QR8 A;  1QXY A;  1WL9 A;  2GG5 A;  2GU7 A;  4OOK A;  4U71 A;  2V3Z A;  3PKC A;  4IKU A;  3TB5 A;  5CDV A;  1BN5 A;  1JAW A;  3FMR A;  4ZWO A;  1W2M A;  2P98 A;  5D6E A;  2BHD A;  5JHU A;  4A6V A;  2B3K A;  2GTX A;  5FCF A;  4U6E A;  4U70 A;  2P9A A;  4IDY A;  2GU5 A;  1QXW A;  1YW9 A;  4IKR A;  2EA2 A;  3CTZ A;  3Q6D A;  3L24 A;  1C23 A;  3BIP A;  1QZY A;  2ZSG A;  4KM3 A;  3TAV A;  2Q94 A;  1XGO A;  3CB6 A;  2IW2 A;  3FM3 A;  1WBQ A;  4IPA A;  4FLJ A;  2MAT A;  2OAZ A;  2GG8 A; 
#chains in the Genus database with same CATH homology
 1C21 A;  2B3H A;  2V3X A;  1WY2 A;  2HOW A;  4PV4 A;  4S2R P;  4ZWU A;  3PKD A;  4FO8 A;  4Z7M A;  1O0X A;  1M35 A;  1KQ0 A;  1Y1N A;  4FKC A;  2OKN A;  3PKE A;  1YW8 A;  2EVC A;  1WN1 A;  1B6A A;  2GG0 A;  4MAT A;  4R60 A;  1PV9 A;  2EA4 A;  4PNC A;  4B28 A;  4U75 A;  3BIT A;  2Q92 A;  3D27 A;  1CHM A;  5JI6 A;  3L7G A;  1YVM A;  2EVO A;  3IU7 A;  2BN7 A;  2Q95 A;  1KP0 A;  1MAT A;  4IEC A;  1BOA A;  2GA2 A;  4JUQ A;  4RZZ A;  2Q96 A;  4U6W A;  2BWW A;  4HXX A;  2BWT A;  4ZNG A;  5FCH A;  3RVA A;  1C27 A;  1W7V A;  2NQ6 A;  2BWU A;  2BB7 A;  3BIQ A;  3IU9 A;  3MAT A;  5CNX A;  2Q93 A;  1WLR A;  1WKM A;  2BHA A;  5CDE A;  3MR1 A;  4A6W A;  2V6C A;  4IKT A;  1XGM A;  1YJ3 A;  2V3Y A;  4IU6 A;  5CLS A;  1B59 A;  1R5G A;  2BWY A;  2GG7 A;  2GZ5 A;  4S00 A;  3CB5 A;  3FMQ A;  1XGS A;  3S6B A;  1C24 A;  5CIK A;  4FLK A;  2BH3 A;  2NQ7 A;  1C22 A;  2ADU A;  2EVM A;  1KQ9 A;  4IKS A;  2GU6 A;  5JFR A;  4RGZ 1;  5CE6 A;  4U6J A;  4FUK A;  2Q8K A;  5E5B A;  1A16 A;  4FO7 A;  4U6Z A;  2GG9 A;  4U1B A;  2G6P A;  1R58 A;  2GGC A;  2P99 A;  1R5H A;  3PKA A;  4RZY A;  1WL6 A;  1QXZ A;  2BHB A;  2BWX A;  4FLI A;  3MX6 A;  4FLL A;  2B3L A;  4ZWP A;  4U6C A;  2GGB A;  4U69 A;  3IG4 A;  2GU4 A;  5D6F A;  4S2T P;  2BWV A;  2BHC A;  4IF7 A;  2BWS A;  1N51 A;  3ROR A;  1XNZ A;  4S01 A;  1XGN A;  3IU8 A;  4U76 A;  1YW7 A;  2GG3 A;  2GG2 A;  2DFI A;  4U73 A;  3PKB A;  4EGE A;  5CDL A;  4QR8 A;  1QXY A;  1WL9 A;  2GG5 A;  2GU7 A;  4OOK A;  4U71 A;  2V3Z A;  3PKC A;  4IKU A;  3TB5 A;  5CDV A;  1BN5 A;  1JAW A;  3FMR A;  4ZWO A;  1W2M A;  2P98 A;  5D6E A;  2BHD A;  5JHU A;  4A6V A;  2B3K A;  2GTX A;  5FCF A;  4U6E A;  4U70 A;  2P9A A;  4IDY A;  2GU5 A;  1QXW A;  1YW9 A;  4IKR A;  2EA2 A;  3CTZ A;  3Q6D A;  3L24 A;  1C23 A;  3BIP A;  1QZY A;  2ZSG A;  4KM3 A;  3TAV A;  2Q94 A;  1XGO A;  3CB6 A;  2IW2 A;  3FM3 A;  1WBQ A;  4IPA A;  4FLJ A;  2MAT A;  2OAZ A;  2GG8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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