2NQ7A

Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2nq7A00
1XGNA 3Q6DA 5CDEA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 4IECA 5CNXA 1CHMA 1C22A 2ZSGA 1R5HA 2GG9A 2V3YA 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 2GU5A 1KQ0A 5CDLA 3L24A 4IDYA 2BWWA 4S01A 1B59A 3MX6A 1Y1NA 2Q95A 5D6FA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 1YJ3A 2BHCA 2BWVA 2NQ7A 2P9AA 3FMQA 1WL6A 1N51A 2GG0A 2BN7A 4FO7A 1WLRA 3CB6A 1WBQA 4U75A 4FUKA 4PV4A 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 2Q94A 2BWYA 5FCFA 5CDVA 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 1YVMA 1XGSA 2BHBA 4S2TP 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 2G6PA 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1C24A 1BN5A
chains in the Genus database with same CATH superfamily
1XGNA 3Q6DA 5CDEA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 4IECA 5CNXA 1CHMA 1C22A 2ZSGA 1R5HA 2GG9A 2V3YA 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 2GU5A 1KQ0A 5CDLA 3L24A 4IDYA 2BWWA 4S01A 1B59A 3MX6A 1Y1NA 2Q95A 5D6FA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 1YJ3A 2BHCA 2BWVA 2NQ7A 2P9AA 3FMQA 1WL6A 1N51A 2GG0A 2BN7A 4FO7A 1WLRA 3CB6A 1WBQA 4U75A 4FUKA 4PV4A 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 2Q94A 2BWYA 5FCFA 5CDVA 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 1YVMA 1XGSA 2BHBA 4S2TP 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 2G6PA 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1C24A 1BN5A
chains in the Genus database with same CATH topology
1XGNA 3Q6DA 5CDEA 1WN1A 5JFRA 2BB7A 1C21A 4FLLA 4S2RP 3PKCA 2EA2A 4R60A 5CLSA 1QXZA 5CE6A 3BIQA 1R5GA 3PKAA 2B3HA 2BHAA 4KM3A 5JHUA 5FCHA 5JI6A 4IKSA 4HXXA 3PKDA 4FLJA 4U6EA 1C27A 3BITA 1A16A 2Q93A 1YW8A 4JUQA 4OOKA 4S00A 2BWUA 4U73A 3BIPA 4ZNGA 4U71A 4RGZ1 1WY2A 1W7VA 4U6WA 1PV9A 2BH3A 1R58A 4U1BA 3PKEA 3FMRA 2EVCA 1QZYA 3IU9A 3MATA 4ZWOA 4PNCA 1O0XA 1W2MA 3MR1A 4U6JA 2V6CA 2OAZA 3IU7A 1KQ9A 1B6AA 2P98A 2HOWA 1QXYA 4IKUA 2GA2A 4U76A 4IECA 5CNXA 1CHMA 1C22A 2ZSGA 1R5HA 2GG9A 2V3YA 2GU6A 2GG2A 2GGCA 2GZ5A 4A6WA 3PKBA 2Q96A 2GU7A 4ZWUA 2BWSA 2DFIA 1YW9A 2V3XA 3CTZA 4RZZA 4B28A 3IG4A 3IU8A 4U69A 4FKCA 3D27A 4Z7MA 1MATA 2ADUA 4IPAA 2V3ZA 4QR8A 1C23A 2MATA 2EVOA 2GU5A 1KQ0A 5CDLA 3L24A 4IDYA 2BWWA 4S01A 1B59A 3MX6A 1Y1NA 2Q95A 5D6FA 4IKTA 2EVMA 3RVAA 3TAVA 2BWTA 2P99A 2GG5A 4A6VA 1M35A 1XNZA 2B3LA 2GG8A 5E5BA 2BWXA 4IU6A 3TB5A 1YJ3A 2BHCA 2BWVA 2NQ7A 2P9AA 3FMQA 1WL6A 1N51A 2GG0A 2BN7A 4FO7A 1WLRA 3CB6A 1WBQA 4U75A 4FUKA 4PV4A 2BHDA 4U6ZA 2NQ6A 4RZYA 4U6CA 4MATA 2OKNA 2Q94A 2BWYA 5FCFA 5CDVA 2EA4A 4FO8A 1WKMA 4FLIA 1XGOA 1YVMA 1XGSA 2BHBA 4S2TP 2Q92A 3CB5A 2GGBA 5D6EA 1WL9A 1BOAA 4EGEA 2IW2A 2GG3A 2G6PA 1QXWA 1JAWA 4FLKA 3S6BA 4ZWPA 1YW7A 2GTXA 2Q8KA 1XGMA 4IKRA 1KP0A 2B3KA 4U70A 2GG7A 4IF7A 5CIKA 3L7GA 3FM3A 3RORA 2GU4A 1C24A 1BN5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XGN A;  3Q6D A;  5CDE A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  4IEC A;  5CNX A;  1CHM A;  1C22 A;  2ZSG A;  1R5H A;  2GG9 A;  2V3Y A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  2GU5 A;  1KQ0 A;  5CDL A;  3L24 A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  1YJ3 A;  2BHC A;  2BWV A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  1N51 A;  2GG0 A;  2BN7 A;  4FO7 A;  1WLR A;  3CB6 A;  1WBQ A;  4U75 A;  4FUK A;  4PV4 A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  2Q94 A;  2BWY A;  5FCF A;  5CDV A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  1YVM A;  1XGS A;  2BHB A;  4S2T P;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  2G6P A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1C24 A;  1BN5 A; 
#chains in the Genus database with same CATH topology
 1XGN A;  3Q6D A;  5CDE A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  4IEC A;  5CNX A;  1CHM A;  1C22 A;  2ZSG A;  1R5H A;  2GG9 A;  2V3Y A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  2GU5 A;  1KQ0 A;  5CDL A;  3L24 A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  1YJ3 A;  2BHC A;  2BWV A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  1N51 A;  2GG0 A;  2BN7 A;  4FO7 A;  1WLR A;  3CB6 A;  1WBQ A;  4U75 A;  4FUK A;  4PV4 A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  2Q94 A;  2BWY A;  5FCF A;  5CDV A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  1YVM A;  1XGS A;  2BHB A;  4S2T P;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  2G6P A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1C24 A;  1BN5 A; 
#chains in the Genus database with same CATH homology
 1XGN A;  3Q6D A;  5CDE A;  1WN1 A;  5JFR A;  2BB7 A;  1C21 A;  4FLL A;  4S2R P;  3PKC A;  2EA2 A;  4R60 A;  5CLS A;  1QXZ A;  5CE6 A;  3BIQ A;  1R5G A;  3PKA A;  2B3H A;  2BHA A;  4KM3 A;  5JHU A;  5FCH A;  5JI6 A;  4IKS A;  4HXX A;  3PKD A;  4FLJ A;  4U6E A;  1C27 A;  3BIT A;  1A16 A;  2Q93 A;  1YW8 A;  4JUQ A;  4OOK A;  4S00 A;  2BWU A;  4U73 A;  3BIP A;  4ZNG A;  4U71 A;  4RGZ 1;  1WY2 A;  1W7V A;  4U6W A;  1PV9 A;  2BH3 A;  1R58 A;  4U1B A;  3PKE A;  3FMR A;  2EVC A;  1QZY A;  3IU9 A;  3MAT A;  4ZWO A;  4PNC A;  1O0X A;  1W2M A;  3MR1 A;  4U6J A;  2V6C A;  2OAZ A;  3IU7 A;  1KQ9 A;  1B6A A;  2P98 A;  2HOW A;  1QXY A;  4IKU A;  2GA2 A;  4U76 A;  4IEC A;  5CNX A;  1CHM A;  1C22 A;  2ZSG A;  1R5H A;  2GG9 A;  2V3Y A;  2GU6 A;  2GG2 A;  2GGC A;  2GZ5 A;  4A6W A;  3PKB A;  2Q96 A;  2GU7 A;  4ZWU A;  2BWS A;  2DFI A;  1YW9 A;  2V3X A;  3CTZ A;  4RZZ A;  4B28 A;  3IG4 A;  3IU8 A;  4U69 A;  4FKC A;  3D27 A;  4Z7M A;  1MAT A;  2ADU A;  4IPA A;  2V3Z A;  4QR8 A;  1C23 A;  2MAT A;  2EVO A;  2GU5 A;  1KQ0 A;  5CDL A;  3L24 A;  4IDY A;  2BWW A;  4S01 A;  1B59 A;  3MX6 A;  1Y1N A;  2Q95 A;  5D6F A;  4IKT A;  2EVM A;  3RVA A;  3TAV A;  2BWT A;  2P99 A;  2GG5 A;  4A6V A;  1M35 A;  1XNZ A;  2B3L A;  2GG8 A;  5E5B A;  2BWX A;  4IU6 A;  3TB5 A;  1YJ3 A;  2BHC A;  2BWV A;  2NQ7 A;  2P9A A;  3FMQ A;  1WL6 A;  1N51 A;  2GG0 A;  2BN7 A;  4FO7 A;  1WLR A;  3CB6 A;  1WBQ A;  4U75 A;  4FUK A;  4PV4 A;  2BHD A;  4U6Z A;  2NQ6 A;  4RZY A;  4U6C A;  4MAT A;  2OKN A;  2Q94 A;  2BWY A;  5FCF A;  5CDV A;  2EA4 A;  4FO8 A;  1WKM A;  4FLI A;  1XGO A;  1YVM A;  1XGS A;  2BHB A;  4S2T P;  2Q92 A;  3CB5 A;  2GGB A;  5D6E A;  1WL9 A;  1BOA A;  4EGE A;  2IW2 A;  2GG3 A;  2G6P A;  1QXW A;  1JAW A;  4FLK A;  3S6B A;  4ZWP A;  1YW7 A;  2GTX A;  2Q8K A;  1XGM A;  4IKR A;  1KP0 A;  2B3K A;  4U70 A;  2GG7 A;  4IF7 A;  5CIK A;  3L7G A;  3FM3 A;  3ROR A;  2GU4 A;  1C24 A;  1BN5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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