2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
1YW9A 4U71A 2EVCA 3PKEA 1XNZA 1JAWA 2NQ7A 2DFIA 2GU5A 3Q6DA 1O0XA 1W2MA 4IECA 4U73A 3PKCA 4ZWOA 2EA2A 5CNXA 4ZWUA 2HOWA 4PNCA 4JUQA 5JHUA 4QR8A 5FCFA 3BITA 2B3HA 4U70A 3D27A 3PKAA 2B3KA 5E5BA 4ZNGA 5CDVA 4A6WA 4FUKA 2BWTA 4S00A 1YVMA 2Q92A 4FLIA 4OOKA 2IW2A 4KM3A 4MATA 1KQ9A 4S2TP 2EVMA 2V3YA 1QXZA 1R58A 2GG7A 2GTXA 3IU9A 1Y1NA 1XGNA 4Z7MA 2V6CA 1XGOA 4HXXA 1WLRA 1C21A 3PKBA 2BHCA 2BHDA 4IKUA 3TAVA 4PV4A 4RGZ1 4B28A 5JI6A 4U69A 1WKMA 5CDLA 4FKCA 2Q96A 4FLJA 4IKTA 1WL6A 4RZYA 4FLKA 1PV9A 2BB7A 1C22A 2BWVA 2GGBA 4FO8A 2Q93A 4EGEA 2OKNA 2GU4A 2Q94A 4R60A 1QXWA 5CE6A 2BWWA 1BN5A 1R5GA 2GG2A 2Q95A 3BIPA 3IU8A 1WN1A 3L24A 2BWYA 1B59A 1QZYA 2BHBA 3CTZA 2BN7A 3S6BA 1BOAA 4U1BA 2BWSA 2OAZA 3CB6A 2BH3A 2B3LA 4FO7A 4IDYA 2EVOA 1WBQA 1C24A 4FLLA 4S01A 1XGSA 5CLSA 2GGCA 3RORA 2BWUA 2P9AA 1YW7A 4S2RP 1C27A 1YJ3A 2G6PA 5D6EA 4U6JA 2ZSGA 5JFRA 1CHMA 3FMQA 1M35A 3MR1A 3CB5A 2P99A 3L7GA 1YW8A 2MATA 2GG9A 3RVAA 2GU7A 4IF7A 4U6CA 1WL9A 2BHAA 5FCHA 4U75A 1W7VA 4U6ZA 2BWXA 4IKSA 4U6WA 4A6VA 4IPAA 3BIQA 1A16A 2EA4A 3IU7A 5D6FA 2GG3A 3MATA 3MX6A 2GG0A 4IU6A 1KP0A 2GA2A 2Q8KA 1KQ0A 1XGMA 5CDEA 1C23A 3FMRA 2NQ6A 1N51A 2V3XA 3TB5A 1WY2A 2GG5A 2P98A 2GG8A 1QXYA 1R5HA 4IKRA 3PKDA 1B6AA 3FM3A 2GZ5A 4ZWPA 3IG4A 4U76A 4U6EA 2V3ZA 4RZZA 2GU6A 2ADUA 5CIKA 1MATA
chains in the Genus database with same CATH superfamily
1YW9A 4U71A 2EVCA 3PKEA 1XNZA 1JAWA 2NQ7A 2DFIA 2GU5A 3Q6DA 1O0XA 1W2MA 4IECA 4U73A 3PKCA 4ZWOA 2EA2A 5CNXA 4ZWUA 2HOWA 4PNCA 4JUQA 5JHUA 4QR8A 5FCFA 3BITA 2B3HA 4U70A 3D27A 3PKAA 2B3KA 5E5BA 4ZNGA 5CDVA 4A6WA 4FUKA 2BWTA 4S00A 1YVMA 2Q92A 4FLIA 4OOKA 2IW2A 4KM3A 4MATA 1KQ9A 4S2TP 2EVMA 2V3YA 1QXZA 1R58A 2GG7A 2GTXA 3IU9A 1Y1NA 1XGNA 4Z7MA 2V6CA 1XGOA 4HXXA 1WLRA 1C21A 3PKBA 2BHCA 2BHDA 4IKUA 3TAVA 4PV4A 4RGZ1 4B28A 5JI6A 4U69A 1WKMA 5CDLA 4FKCA 2Q96A 4FLJA 4IKTA 1WL6A 4RZYA 4FLKA 1PV9A 2BB7A 1C22A 2BWVA 2GGBA 4FO8A 2Q93A 4EGEA 2OKNA 2GU4A 2Q94A 4R60A 1QXWA 5CE6A 2BWWA 1BN5A 1R5GA 2GG2A 2Q95A 3BIPA 3IU8A 1WN1A 3L24A 2BWYA 1B59A 1QZYA 2BHBA 3CTZA 2BN7A 3S6BA 1BOAA 4U1BA 2BWSA 2OAZA 3CB6A 2BH3A 2B3LA 4FO7A 4IDYA 2EVOA 1WBQA 1C24A 4FLLA 4S01A 1XGSA 5CLSA 2GGCA 3RORA 2BWUA 2P9AA 1YW7A 4S2RP 1C27A 1YJ3A 2G6PA 5D6EA 4U6JA 2ZSGA 5JFRA 1CHMA 3FMQA 1M35A 3MR1A 3CB5A 2P99A 3L7GA 1YW8A 2MATA 2GG9A 3RVAA 2GU7A 4IF7A 4U6CA 1WL9A 2BHAA 5FCHA 4U75A 1W7VA 4U6ZA 2BWXA 4IKSA 4U6WA 4A6VA 4IPAA 3BIQA 1A16A 2EA4A 3IU7A 5D6FA 2GG3A 3MATA 3MX6A 2GG0A 4IU6A 1KP0A 2GA2A 2Q8KA 1KQ0A 1XGMA 5CDEA 1C23A 3FMRA 2NQ6A 1N51A 2V3XA 3TB5A 1WY2A 2GG5A 2P98A 2GG8A 1QXYA 1R5HA 4IKRA 3PKDA 1B6AA 3FM3A 2GZ5A 4ZWPA 3IG4A 4U76A 4U6EA 2V3ZA 4RZZA 2GU6A 2ADUA 5CIKA 1MATA
chains in the Genus database with same CATH topology
1YW9A 4U71A 2EVCA 3PKEA 1XNZA 1JAWA 2NQ7A 2DFIA 2GU5A 3Q6DA 1O0XA 1W2MA 4IECA 4U73A 3PKCA 4ZWOA 2EA2A 5CNXA 4ZWUA 2HOWA 4PNCA 4JUQA 5JHUA 4QR8A 5FCFA 3BITA 2B3HA 4U70A 3D27A 3PKAA 2B3KA 5E5BA 4ZNGA 5CDVA 4A6WA 4FUKA 2BWTA 4S00A 1YVMA 2Q92A 4FLIA 4OOKA 2IW2A 4KM3A 4MATA 1KQ9A 4S2TP 2EVMA 2V3YA 1QXZA 1R58A 2GG7A 2GTXA 3IU9A 1Y1NA 1XGNA 4Z7MA 2V6CA 1XGOA 4HXXA 1WLRA 1C21A 3PKBA 2BHCA 2BHDA 4IKUA 3TAVA 4PV4A 4RGZ1 4B28A 5JI6A 4U69A 1WKMA 5CDLA 4FKCA 2Q96A 4FLJA 4IKTA 1WL6A 4RZYA 4FLKA 1PV9A 2BB7A 1C22A 2BWVA 2GGBA 4FO8A 2Q93A 4EGEA 2OKNA 2GU4A 2Q94A 4R60A 1QXWA 5CE6A 2BWWA 1BN5A 1R5GA 2GG2A 2Q95A 3BIPA 3IU8A 1WN1A 3L24A 2BWYA 1B59A 1QZYA 2BHBA 3CTZA 2BN7A 3S6BA 1BOAA 4U1BA 2BWSA 2OAZA 3CB6A 2BH3A 2B3LA 4FO7A 4IDYA 2EVOA 1WBQA 1C24A 4FLLA 4S01A 1XGSA 5CLSA 2GGCA 3RORA 2BWUA 2P9AA 1YW7A 4S2RP 1C27A 1YJ3A 2G6PA 5D6EA 4U6JA 2ZSGA 5JFRA 1CHMA 3FMQA 1M35A 3MR1A 3CB5A 2P99A 3L7GA 1YW8A 2MATA 2GG9A 3RVAA 2GU7A 4IF7A 4U6CA 1WL9A 2BHAA 5FCHA 4U75A 1W7VA 4U6ZA 2BWXA 4IKSA 4U6WA 4A6VA 4IPAA 3BIQA 1A16A 2EA4A 3IU7A 5D6FA 2GG3A 3MATA 3MX6A 2GG0A 4IU6A 1KP0A 2GA2A 2Q8KA 1KQ0A 1XGMA 5CDEA 1C23A 3FMRA 2NQ6A 1N51A 2V3XA 3TB5A 1WY2A 2GG5A 2P98A 2GG8A 1QXYA 1R5HA 4IKRA 3PKDA 1B6AA 3FM3A 2GZ5A 4ZWPA 3IG4A 4U76A 4U6EA 2V3ZA 4RZZA 2GU6A 2ADUA 5CIKA 1MATA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YW9 A;  4U71 A;  2EVC A;  3PKE A;  1XNZ A;  1JAW A;  2NQ7 A;  2DFI A;  2GU5 A;  3Q6D A;  1O0X A;  1W2M A;  4IEC A;  4U73 A;  3PKC A;  4ZWO A;  2EA2 A;  5CNX A;  4ZWU A;  2HOW A;  4PNC A;  4JUQ A;  5JHU A;  4QR8 A;  5FCF A;  3BIT A;  2B3H A;  4U70 A;  3D27 A;  3PKA A;  2B3K A;  5E5B A;  4ZNG A;  5CDV A;  4A6W A;  4FUK A;  2BWT A;  4S00 A;  1YVM A;  2Q92 A;  4FLI A;  4OOK A;  2IW2 A;  4KM3 A;  4MAT A;  1KQ9 A;  4S2T P;  2EVM A;  2V3Y A;  1QXZ A;  1R58 A;  2GG7 A;  2GTX A;  3IU9 A;  1Y1N A;  1XGN A;  4Z7M A;  2V6C A;  1XGO A;  4HXX A;  1WLR A;  1C21 A;  3PKB A;  2BHC A;  2BHD A;  4IKU A;  3TAV A;  4PV4 A;  4RGZ 1;  4B28 A;  5JI6 A;  4U69 A;  1WKM A;  5CDL A;  4FKC A;  2Q96 A;  4FLJ A;  4IKT A;  1WL6 A;  4RZY A;  4FLK A;  1PV9 A;  2BB7 A;  1C22 A;  2BWV A;  2GGB A;  4FO8 A;  2Q93 A;  4EGE A;  2OKN A;  2GU4 A;  2Q94 A;  4R60 A;  1QXW A;  5CE6 A;  2BWW A;  1BN5 A;  1R5G A;  2GG2 A;  2Q95 A;  3BIP A;  3IU8 A;  1WN1 A;  3L24 A;  2BWY A;  1B59 A;  1QZY A;  2BHB A;  3CTZ A;  2BN7 A;  3S6B A;  1BOA A;  4U1B A;  2BWS A;  2OAZ A;  3CB6 A;  2BH3 A;  2B3L A;  4FO7 A;  4IDY A;  2EVO A;  1WBQ A;  1C24 A;  4FLL A;  4S01 A;  1XGS A;  5CLS A;  2GGC A;  3ROR A;  2BWU A;  2P9A A;  1YW7 A;  4S2R P;  1C27 A;  1YJ3 A;  2G6P A;  5D6E A;  4U6J A;  2ZSG A;  5JFR A;  1CHM A;  3FMQ A;  1M35 A;  3MR1 A;  3CB5 A;  2P99 A;  3L7G A;  1YW8 A;  2MAT A;  2GG9 A;  3RVA A;  2GU7 A;  4IF7 A;  4U6C A;  1WL9 A;  2BHA A;  5FCH A;  4U75 A;  1W7V A;  4U6Z A;  2BWX A;  4IKS A;  4U6W A;  4A6V A;  4IPA A;  3BIQ A;  1A16 A;  2EA4 A;  3IU7 A;  5D6F A;  2GG3 A;  3MAT A;  3MX6 A;  2GG0 A;  4IU6 A;  1KP0 A;  2GA2 A;  2Q8K A;  1KQ0 A;  1XGM A;  5CDE A;  1C23 A;  3FMR A;  2NQ6 A;  1N51 A;  2V3X A;  3TB5 A;  1WY2 A;  2GG5 A;  2P98 A;  2GG8 A;  1QXY A;  1R5H A;  4IKR A;  3PKD A;  1B6A A;  3FM3 A;  2GZ5 A;  4ZWP A;  3IG4 A;  4U76 A;  4U6E A;  2V3Z A;  4RZZ A;  2GU6 A;  2ADU A;  5CIK A;  1MAT A; 
#chains in the Genus database with same CATH topology
 1YW9 A;  4U71 A;  2EVC A;  3PKE A;  1XNZ A;  1JAW A;  2NQ7 A;  2DFI A;  2GU5 A;  3Q6D A;  1O0X A;  1W2M A;  4IEC A;  4U73 A;  3PKC A;  4ZWO A;  2EA2 A;  5CNX A;  4ZWU A;  2HOW A;  4PNC A;  4JUQ A;  5JHU A;  4QR8 A;  5FCF A;  3BIT A;  2B3H A;  4U70 A;  3D27 A;  3PKA A;  2B3K A;  5E5B A;  4ZNG A;  5CDV A;  4A6W A;  4FUK A;  2BWT A;  4S00 A;  1YVM A;  2Q92 A;  4FLI A;  4OOK A;  2IW2 A;  4KM3 A;  4MAT A;  1KQ9 A;  4S2T P;  2EVM A;  2V3Y A;  1QXZ A;  1R58 A;  2GG7 A;  2GTX A;  3IU9 A;  1Y1N A;  1XGN A;  4Z7M A;  2V6C A;  1XGO A;  4HXX A;  1WLR A;  1C21 A;  3PKB A;  2BHC A;  2BHD A;  4IKU A;  3TAV A;  4PV4 A;  4RGZ 1;  4B28 A;  5JI6 A;  4U69 A;  1WKM A;  5CDL A;  4FKC A;  2Q96 A;  4FLJ A;  4IKT A;  1WL6 A;  4RZY A;  4FLK A;  1PV9 A;  2BB7 A;  1C22 A;  2BWV A;  2GGB A;  4FO8 A;  2Q93 A;  4EGE A;  2OKN A;  2GU4 A;  2Q94 A;  4R60 A;  1QXW A;  5CE6 A;  2BWW A;  1BN5 A;  1R5G A;  2GG2 A;  2Q95 A;  3BIP A;  3IU8 A;  1WN1 A;  3L24 A;  2BWY A;  1B59 A;  1QZY A;  2BHB A;  3CTZ A;  2BN7 A;  3S6B A;  1BOA A;  4U1B A;  2BWS A;  2OAZ A;  3CB6 A;  2BH3 A;  2B3L A;  4FO7 A;  4IDY A;  2EVO A;  1WBQ A;  1C24 A;  4FLL A;  4S01 A;  1XGS A;  5CLS A;  2GGC A;  3ROR A;  2BWU A;  2P9A A;  1YW7 A;  4S2R P;  1C27 A;  1YJ3 A;  2G6P A;  5D6E A;  4U6J A;  2ZSG A;  5JFR A;  1CHM A;  3FMQ A;  1M35 A;  3MR1 A;  3CB5 A;  2P99 A;  3L7G A;  1YW8 A;  2MAT A;  2GG9 A;  3RVA A;  2GU7 A;  4IF7 A;  4U6C A;  1WL9 A;  2BHA A;  5FCH A;  4U75 A;  1W7V A;  4U6Z A;  2BWX A;  4IKS A;  4U6W A;  4A6V A;  4IPA A;  3BIQ A;  1A16 A;  2EA4 A;  3IU7 A;  5D6F A;  2GG3 A;  3MAT A;  3MX6 A;  2GG0 A;  4IU6 A;  1KP0 A;  2GA2 A;  2Q8K A;  1KQ0 A;  1XGM A;  5CDE A;  1C23 A;  3FMR A;  2NQ6 A;  1N51 A;  2V3X A;  3TB5 A;  1WY2 A;  2GG5 A;  2P98 A;  2GG8 A;  1QXY A;  1R5H A;  4IKR A;  3PKD A;  1B6A A;  3FM3 A;  2GZ5 A;  4ZWP A;  3IG4 A;  4U76 A;  4U6E A;  2V3Z A;  4RZZ A;  2GU6 A;  2ADU A;  5CIK A;  1MAT A; 
#chains in the Genus database with same CATH homology
 1YW9 A;  4U71 A;  2EVC A;  3PKE A;  1XNZ A;  1JAW A;  2NQ7 A;  2DFI A;  2GU5 A;  3Q6D A;  1O0X A;  1W2M A;  4IEC A;  4U73 A;  3PKC A;  4ZWO A;  2EA2 A;  5CNX A;  4ZWU A;  2HOW A;  4PNC A;  4JUQ A;  5JHU A;  4QR8 A;  5FCF A;  3BIT A;  2B3H A;  4U70 A;  3D27 A;  3PKA A;  2B3K A;  5E5B A;  4ZNG A;  5CDV A;  4A6W A;  4FUK A;  2BWT A;  4S00 A;  1YVM A;  2Q92 A;  4FLI A;  4OOK A;  2IW2 A;  4KM3 A;  4MAT A;  1KQ9 A;  4S2T P;  2EVM A;  2V3Y A;  1QXZ A;  1R58 A;  2GG7 A;  2GTX A;  3IU9 A;  1Y1N A;  1XGN A;  4Z7M A;  2V6C A;  1XGO A;  4HXX A;  1WLR A;  1C21 A;  3PKB A;  2BHC A;  2BHD A;  4IKU A;  3TAV A;  4PV4 A;  4RGZ 1;  4B28 A;  5JI6 A;  4U69 A;  1WKM A;  5CDL A;  4FKC A;  2Q96 A;  4FLJ A;  4IKT A;  1WL6 A;  4RZY A;  4FLK A;  1PV9 A;  2BB7 A;  1C22 A;  2BWV A;  2GGB A;  4FO8 A;  2Q93 A;  4EGE A;  2OKN A;  2GU4 A;  2Q94 A;  4R60 A;  1QXW A;  5CE6 A;  2BWW A;  1BN5 A;  1R5G A;  2GG2 A;  2Q95 A;  3BIP A;  3IU8 A;  1WN1 A;  3L24 A;  2BWY A;  1B59 A;  1QZY A;  2BHB A;  3CTZ A;  2BN7 A;  3S6B A;  1BOA A;  4U1B A;  2BWS A;  2OAZ A;  3CB6 A;  2BH3 A;  2B3L A;  4FO7 A;  4IDY A;  2EVO A;  1WBQ A;  1C24 A;  4FLL A;  4S01 A;  1XGS A;  5CLS A;  2GGC A;  3ROR A;  2BWU A;  2P9A A;  1YW7 A;  4S2R P;  1C27 A;  1YJ3 A;  2G6P A;  5D6E A;  4U6J A;  2ZSG A;  5JFR A;  1CHM A;  3FMQ A;  1M35 A;  3MR1 A;  3CB5 A;  2P99 A;  3L7G A;  1YW8 A;  2MAT A;  2GG9 A;  3RVA A;  2GU7 A;  4IF7 A;  4U6C A;  1WL9 A;  2BHA A;  5FCH A;  4U75 A;  1W7V A;  4U6Z A;  2BWX A;  4IKS A;  4U6W A;  4A6V A;  4IPA A;  3BIQ A;  1A16 A;  2EA4 A;  3IU7 A;  5D6F A;  2GG3 A;  3MAT A;  3MX6 A;  2GG0 A;  4IU6 A;  1KP0 A;  2GA2 A;  2Q8K A;  1KQ0 A;  1XGM A;  5CDE A;  1C23 A;  3FMR A;  2NQ6 A;  1N51 A;  2V3X A;  3TB5 A;  1WY2 A;  2GG5 A;  2P98 A;  2GG8 A;  1QXY A;  1R5H A;  4IKR A;  3PKD A;  1B6A A;  3FM3 A;  2GZ5 A;  4ZWP A;  3IG4 A;  4U76 A;  4U6E A;  2V3Z A;  4RZZ A;  2GU6 A;  2ADU A;  5CIK A;  1MAT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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