2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
1WLRA 4ZWOA 2P99A 1XGMA 3PKBA 3FMQA 4OOKA 2DFIA 4A6WA 1N51A 4IU6A 2GU5A 3CB5A 2BWVA 5D6EA 2Q92A 2GG5A 2V3YA 5E5BA 4RGZ1 1R58A 1XGSA 1Y1NA 1A16A 2G6PA 1KQ9A 4U6WA 2EVMA 2GG8A 3RVAA 4U1BA 2BH3A 4IKUA 4U75A 5CDEA 3PKAA 1WY2A 2GGBA 2BHBA 2EVOA 2GG3A 3L7GA 5CDVA 1C21A 2BHCA 2Q8KA 2MATA 3MATA 1C24A 3L24A 1B59A 2BN7A 1W2MA 2GG7A 3IG4A 4S2TP 4PV4A 4ZNGA 4S2RP 2OKNA 3IU7A 1O0XA 1KQ0A 5CNXA 2GG9A 4Z7MA 3CTZA 4A6VA 2Q93A 4JUQA 5JFRA 5FCHA 4RZYA 2GA2A 2GG0A 2GZ5A 2Q96A 1B6AA 1WL9A 1YW8A 1YW7A 1YVMA 2BHAA 2V6CA 3S6BA 4S00A 1WBQA 4KM3A 4U70A 5JI6A 3PKEA 4IKTA 2BB7A 5FCFA 4ZWUA 4FO8A 3PKDA 5JHUA 2BWXA 3RORA 5CE6A 4PNCA 1BOAA 3MX6A 3BIQA 4S01A 1MATA 5CIKA 4FLIA 2BWUA 4HXXA 4U76A 2GG2A 2GTXA 3Q6DA 2BWSA 4U69A 2GU4A 2EA4A 2BWYA 1PV9A 4QR8A 1M35A 2V3ZA 1WL6A 4IECA 1XGOA 2GU6A 4IKRA 1C23A 2NQ7A 4FLLA 1QXZA 2B3LA 1WN1A 1YW9A 1KP0A 1XGNA 2OAZA 4R60A 2ZSGA 4IF7A 4U6JA 1QXWA 2BHDA 3TB5A 2ADUA 1R5HA 2B3KA 2P9AA 3CB6A 4IPAA 3BITA 3BIPA 2IW2A 4RZZA 2BWTA 1WKMA 2EA2A 3FM3A 3IU9A 1QXYA 1XNZA 1R5GA 3FMRA 5CDLA 1C27A 4ZWPA 2GU7A 1JAWA 2HOWA 4FUKA 3TAVA 2GGCA 4EGEA 5D6FA 4U73A 2Q95A 3PKCA 2Q94A 4U6EA 3MR1A 1CHMA 2V3XA 4FLKA 1QZYA 4IDYA 4U71A 1BN5A 4U6ZA 2P98A 5CLSA 1W7VA 2NQ6A 3IU8A 4FLJA 4IKSA 1YJ3A 2EVCA 3D27A 4FKCA 4MATA 4FO7A 2B3HA 2BWWA 4U6CA 4B28A 1C22A
chains in the Genus database with same CATH superfamily
1WLRA 4ZWOA 2P99A 1XGMA 3PKBA 3FMQA 4OOKA 2DFIA 4A6WA 1N51A 4IU6A 2GU5A 3CB5A 2BWVA 5D6EA 2Q92A 2GG5A 2V3YA 5E5BA 4RGZ1 1R58A 1XGSA 1Y1NA 1A16A 2G6PA 1KQ9A 4U6WA 2EVMA 2GG8A 3RVAA 4U1BA 2BH3A 4IKUA 4U75A 5CDEA 3PKAA 1WY2A 2GGBA 2BHBA 2EVOA 2GG3A 3L7GA 5CDVA 1C21A 2BHCA 2Q8KA 2MATA 3MATA 1C24A 3L24A 1B59A 2BN7A 1W2MA 2GG7A 3IG4A 4S2TP 4PV4A 4ZNGA 4S2RP 2OKNA 3IU7A 1O0XA 1KQ0A 5CNXA 2GG9A 4Z7MA 3CTZA 4A6VA 2Q93A 4JUQA 5JFRA 5FCHA 4RZYA 2GA2A 2GG0A 2GZ5A 2Q96A 1B6AA 1WL9A 1YW8A 1YW7A 1YVMA 2BHAA 2V6CA 3S6BA 4S00A 1WBQA 4KM3A 4U70A 5JI6A 3PKEA 4IKTA 2BB7A 5FCFA 4ZWUA 4FO8A 3PKDA 5JHUA 2BWXA 3RORA 5CE6A 4PNCA 1BOAA 3MX6A 3BIQA 4S01A 1MATA 5CIKA 4FLIA 2BWUA 4HXXA 4U76A 2GG2A 2GTXA 3Q6DA 2BWSA 4U69A 2GU4A 2EA4A 2BWYA 1PV9A 4QR8A 1M35A 2V3ZA 1WL6A 4IECA 1XGOA 2GU6A 4IKRA 1C23A 2NQ7A 4FLLA 1QXZA 2B3LA 1WN1A 1YW9A 1KP0A 1XGNA 2OAZA 4R60A 2ZSGA 4IF7A 4U6JA 1QXWA 2BHDA 3TB5A 2ADUA 1R5HA 2B3KA 2P9AA 3CB6A 4IPAA 3BITA 3BIPA 2IW2A 4RZZA 2BWTA 1WKMA 2EA2A 3FM3A 3IU9A 1QXYA 1XNZA 1R5GA 3FMRA 5CDLA 1C27A 4ZWPA 2GU7A 1JAWA 2HOWA 4FUKA 3TAVA 2GGCA 4EGEA 5D6FA 4U73A 2Q95A 3PKCA 2Q94A 4U6EA 3MR1A 1CHMA 2V3XA 4FLKA 1QZYA 4IDYA 4U71A 1BN5A 4U6ZA 2P98A 5CLSA 1W7VA 2NQ6A 3IU8A 4FLJA 4IKSA 1YJ3A 2EVCA 3D27A 4FKCA 4MATA 4FO7A 2B3HA 2BWWA 4U6CA 4B28A 1C22A
chains in the Genus database with same CATH topology
1WLRA 4ZWOA 2P99A 1XGMA 3PKBA 3FMQA 4OOKA 2DFIA 4A6WA 1N51A 4IU6A 2GU5A 3CB5A 2BWVA 5D6EA 2Q92A 2GG5A 2V3YA 5E5BA 4RGZ1 1R58A 1XGSA 1Y1NA 1A16A 2G6PA 1KQ9A 4U6WA 2EVMA 2GG8A 3RVAA 4U1BA 2BH3A 4IKUA 4U75A 5CDEA 3PKAA 1WY2A 2GGBA 2BHBA 2EVOA 2GG3A 3L7GA 5CDVA 1C21A 2BHCA 2Q8KA 2MATA 3MATA 1C24A 3L24A 1B59A 2BN7A 1W2MA 2GG7A 3IG4A 4S2TP 4PV4A 4ZNGA 4S2RP 2OKNA 3IU7A 1O0XA 1KQ0A 5CNXA 2GG9A 4Z7MA 3CTZA 4A6VA 2Q93A 4JUQA 5JFRA 5FCHA 4RZYA 2GA2A 2GG0A 2GZ5A 2Q96A 1B6AA 1WL9A 1YW8A 1YW7A 1YVMA 2BHAA 2V6CA 3S6BA 4S00A 1WBQA 4KM3A 4U70A 5JI6A 3PKEA 4IKTA 2BB7A 5FCFA 4ZWUA 4FO8A 3PKDA 5JHUA 2BWXA 3RORA 5CE6A 4PNCA 1BOAA 3MX6A 3BIQA 4S01A 1MATA 5CIKA 4FLIA 2BWUA 4HXXA 4U76A 2GG2A 2GTXA 3Q6DA 2BWSA 4U69A 2GU4A 2EA4A 2BWYA 1PV9A 4QR8A 1M35A 2V3ZA 1WL6A 4IECA 1XGOA 2GU6A 4IKRA 1C23A 2NQ7A 4FLLA 1QXZA 2B3LA 1WN1A 1YW9A 1KP0A 1XGNA 2OAZA 4R60A 2ZSGA 4IF7A 4U6JA 1QXWA 2BHDA 3TB5A 2ADUA 1R5HA 2B3KA 2P9AA 3CB6A 4IPAA 3BITA 3BIPA 2IW2A 4RZZA 2BWTA 1WKMA 2EA2A 3FM3A 3IU9A 1QXYA 1XNZA 1R5GA 3FMRA 5CDLA 1C27A 4ZWPA 2GU7A 1JAWA 2HOWA 4FUKA 3TAVA 2GGCA 4EGEA 5D6FA 4U73A 2Q95A 3PKCA 2Q94A 4U6EA 3MR1A 1CHMA 2V3XA 4FLKA 1QZYA 4IDYA 4U71A 1BN5A 4U6ZA 2P98A 5CLSA 1W7VA 2NQ6A 3IU8A 4FLJA 4IKSA 1YJ3A 2EVCA 3D27A 4FKCA 4MATA 4FO7A 2B3HA 2BWWA 4U6CA 4B28A 1C22A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1WLR A;  4ZWO A;  2P99 A;  1XGM A;  3PKB A;  3FMQ A;  4OOK A;  2DFI A;  4A6W A;  1N51 A;  4IU6 A;  2GU5 A;  3CB5 A;  2BWV A;  5D6E A;  2Q92 A;  2GG5 A;  2V3Y A;  5E5B A;  4RGZ 1;  1R58 A;  1XGS A;  1Y1N A;  1A16 A;  2G6P A;  1KQ9 A;  4U6W A;  2EVM A;  2GG8 A;  3RVA A;  4U1B A;  2BH3 A;  4IKU A;  4U75 A;  5CDE A;  3PKA A;  1WY2 A;  2GGB A;  2BHB A;  2EVO A;  2GG3 A;  3L7G A;  5CDV A;  1C21 A;  2BHC A;  2Q8K A;  2MAT A;  3MAT A;  1C24 A;  3L24 A;  1B59 A;  2BN7 A;  1W2M A;  2GG7 A;  3IG4 A;  4S2T P;  4PV4 A;  4ZNG A;  4S2R P;  2OKN A;  3IU7 A;  1O0X A;  1KQ0 A;  5CNX A;  2GG9 A;  4Z7M A;  3CTZ A;  4A6V A;  2Q93 A;  4JUQ A;  5JFR A;  5FCH A;  4RZY A;  2GA2 A;  2GG0 A;  2GZ5 A;  2Q96 A;  1B6A A;  1WL9 A;  1YW8 A;  1YW7 A;  1YVM A;  2BHA A;  2V6C A;  3S6B A;  4S00 A;  1WBQ A;  4KM3 A;  4U70 A;  5JI6 A;  3PKE A;  4IKT A;  2BB7 A;  5FCF A;  4ZWU A;  4FO8 A;  3PKD A;  5JHU A;  2BWX A;  3ROR A;  5CE6 A;  4PNC A;  1BOA A;  3MX6 A;  3BIQ A;  4S01 A;  1MAT A;  5CIK A;  4FLI A;  2BWU A;  4HXX A;  4U76 A;  2GG2 A;  2GTX A;  3Q6D A;  2BWS A;  4U69 A;  2GU4 A;  2EA4 A;  2BWY A;  1PV9 A;  4QR8 A;  1M35 A;  2V3Z A;  1WL6 A;  4IEC A;  1XGO A;  2GU6 A;  4IKR A;  1C23 A;  2NQ7 A;  4FLL A;  1QXZ A;  2B3L A;  1WN1 A;  1YW9 A;  1KP0 A;  1XGN A;  2OAZ A;  4R60 A;  2ZSG A;  4IF7 A;  4U6J A;  1QXW A;  2BHD A;  3TB5 A;  2ADU A;  1R5H A;  2B3K A;  2P9A A;  3CB6 A;  4IPA A;  3BIT A;  3BIP A;  2IW2 A;  4RZZ A;  2BWT A;  1WKM A;  2EA2 A;  3FM3 A;  3IU9 A;  1QXY A;  1XNZ A;  1R5G A;  3FMR A;  5CDL A;  1C27 A;  4ZWP A;  2GU7 A;  1JAW A;  2HOW A;  4FUK A;  3TAV A;  2GGC A;  4EGE A;  5D6F A;  4U73 A;  2Q95 A;  3PKC A;  2Q94 A;  4U6E A;  3MR1 A;  1CHM A;  2V3X A;  4FLK A;  1QZY A;  4IDY A;  4U71 A;  1BN5 A;  4U6Z A;  2P98 A;  5CLS A;  1W7V A;  2NQ6 A;  3IU8 A;  4FLJ A;  4IKS A;  1YJ3 A;  2EVC A;  3D27 A;  4FKC A;  4MAT A;  4FO7 A;  2B3H A;  2BWW A;  4U6C A;  4B28 A;  1C22 A; 
#chains in the Genus database with same CATH topology
 1WLR A;  4ZWO A;  2P99 A;  1XGM A;  3PKB A;  3FMQ A;  4OOK A;  2DFI A;  4A6W A;  1N51 A;  4IU6 A;  2GU5 A;  3CB5 A;  2BWV A;  5D6E A;  2Q92 A;  2GG5 A;  2V3Y A;  5E5B A;  4RGZ 1;  1R58 A;  1XGS A;  1Y1N A;  1A16 A;  2G6P A;  1KQ9 A;  4U6W A;  2EVM A;  2GG8 A;  3RVA A;  4U1B A;  2BH3 A;  4IKU A;  4U75 A;  5CDE A;  3PKA A;  1WY2 A;  2GGB A;  2BHB A;  2EVO A;  2GG3 A;  3L7G A;  5CDV A;  1C21 A;  2BHC A;  2Q8K A;  2MAT A;  3MAT A;  1C24 A;  3L24 A;  1B59 A;  2BN7 A;  1W2M A;  2GG7 A;  3IG4 A;  4S2T P;  4PV4 A;  4ZNG A;  4S2R P;  2OKN A;  3IU7 A;  1O0X A;  1KQ0 A;  5CNX A;  2GG9 A;  4Z7M A;  3CTZ A;  4A6V A;  2Q93 A;  4JUQ A;  5JFR A;  5FCH A;  4RZY A;  2GA2 A;  2GG0 A;  2GZ5 A;  2Q96 A;  1B6A A;  1WL9 A;  1YW8 A;  1YW7 A;  1YVM A;  2BHA A;  2V6C A;  3S6B A;  4S00 A;  1WBQ A;  4KM3 A;  4U70 A;  5JI6 A;  3PKE A;  4IKT A;  2BB7 A;  5FCF A;  4ZWU A;  4FO8 A;  3PKD A;  5JHU A;  2BWX A;  3ROR A;  5CE6 A;  4PNC A;  1BOA A;  3MX6 A;  3BIQ A;  4S01 A;  1MAT A;  5CIK A;  4FLI A;  2BWU A;  4HXX A;  4U76 A;  2GG2 A;  2GTX A;  3Q6D A;  2BWS A;  4U69 A;  2GU4 A;  2EA4 A;  2BWY A;  1PV9 A;  4QR8 A;  1M35 A;  2V3Z A;  1WL6 A;  4IEC A;  1XGO A;  2GU6 A;  4IKR A;  1C23 A;  2NQ7 A;  4FLL A;  1QXZ A;  2B3L A;  1WN1 A;  1YW9 A;  1KP0 A;  1XGN A;  2OAZ A;  4R60 A;  2ZSG A;  4IF7 A;  4U6J A;  1QXW A;  2BHD A;  3TB5 A;  2ADU A;  1R5H A;  2B3K A;  2P9A A;  3CB6 A;  4IPA A;  3BIT A;  3BIP A;  2IW2 A;  4RZZ A;  2BWT A;  1WKM A;  2EA2 A;  3FM3 A;  3IU9 A;  1QXY A;  1XNZ A;  1R5G A;  3FMR A;  5CDL A;  1C27 A;  4ZWP A;  2GU7 A;  1JAW A;  2HOW A;  4FUK A;  3TAV A;  2GGC A;  4EGE A;  5D6F A;  4U73 A;  2Q95 A;  3PKC A;  2Q94 A;  4U6E A;  3MR1 A;  1CHM A;  2V3X A;  4FLK A;  1QZY A;  4IDY A;  4U71 A;  1BN5 A;  4U6Z A;  2P98 A;  5CLS A;  1W7V A;  2NQ6 A;  3IU8 A;  4FLJ A;  4IKS A;  1YJ3 A;  2EVC A;  3D27 A;  4FKC A;  4MAT A;  4FO7 A;  2B3H A;  2BWW A;  4U6C A;  4B28 A;  1C22 A; 
#chains in the Genus database with same CATH homology
 1WLR A;  4ZWO A;  2P99 A;  1XGM A;  3PKB A;  3FMQ A;  4OOK A;  2DFI A;  4A6W A;  1N51 A;  4IU6 A;  2GU5 A;  3CB5 A;  2BWV A;  5D6E A;  2Q92 A;  2GG5 A;  2V3Y A;  5E5B A;  4RGZ 1;  1R58 A;  1XGS A;  1Y1N A;  1A16 A;  2G6P A;  1KQ9 A;  4U6W A;  2EVM A;  2GG8 A;  3RVA A;  4U1B A;  2BH3 A;  4IKU A;  4U75 A;  5CDE A;  3PKA A;  1WY2 A;  2GGB A;  2BHB A;  2EVO A;  2GG3 A;  3L7G A;  5CDV A;  1C21 A;  2BHC A;  2Q8K A;  2MAT A;  3MAT A;  1C24 A;  3L24 A;  1B59 A;  2BN7 A;  1W2M A;  2GG7 A;  3IG4 A;  4S2T P;  4PV4 A;  4ZNG A;  4S2R P;  2OKN A;  3IU7 A;  1O0X A;  1KQ0 A;  5CNX A;  2GG9 A;  4Z7M A;  3CTZ A;  4A6V A;  2Q93 A;  4JUQ A;  5JFR A;  5FCH A;  4RZY A;  2GA2 A;  2GG0 A;  2GZ5 A;  2Q96 A;  1B6A A;  1WL9 A;  1YW8 A;  1YW7 A;  1YVM A;  2BHA A;  2V6C A;  3S6B A;  4S00 A;  1WBQ A;  4KM3 A;  4U70 A;  5JI6 A;  3PKE A;  4IKT A;  2BB7 A;  5FCF A;  4ZWU A;  4FO8 A;  3PKD A;  5JHU A;  2BWX A;  3ROR A;  5CE6 A;  4PNC A;  1BOA A;  3MX6 A;  3BIQ A;  4S01 A;  1MAT A;  5CIK A;  4FLI A;  2BWU A;  4HXX A;  4U76 A;  2GG2 A;  2GTX A;  3Q6D A;  2BWS A;  4U69 A;  2GU4 A;  2EA4 A;  2BWY A;  1PV9 A;  4QR8 A;  1M35 A;  2V3Z A;  1WL6 A;  4IEC A;  1XGO A;  2GU6 A;  4IKR A;  1C23 A;  2NQ7 A;  4FLL A;  1QXZ A;  2B3L A;  1WN1 A;  1YW9 A;  1KP0 A;  1XGN A;  2OAZ A;  4R60 A;  2ZSG A;  4IF7 A;  4U6J A;  1QXW A;  2BHD A;  3TB5 A;  2ADU A;  1R5H A;  2B3K A;  2P9A A;  3CB6 A;  4IPA A;  3BIT A;  3BIP A;  2IW2 A;  4RZZ A;  2BWT A;  1WKM A;  2EA2 A;  3FM3 A;  3IU9 A;  1QXY A;  1XNZ A;  1R5G A;  3FMR A;  5CDL A;  1C27 A;  4ZWP A;  2GU7 A;  1JAW A;  2HOW A;  4FUK A;  3TAV A;  2GGC A;  4EGE A;  5D6F A;  4U73 A;  2Q95 A;  3PKC A;  2Q94 A;  4U6E A;  3MR1 A;  1CHM A;  2V3X A;  4FLK A;  1QZY A;  4IDY A;  4U71 A;  1BN5 A;  4U6Z A;  2P98 A;  5CLS A;  1W7V A;  2NQ6 A;  3IU8 A;  4FLJ A;  4IKS A;  1YJ3 A;  2EVC A;  3D27 A;  4FKC A;  4MAT A;  4FO7 A;  2B3H A;  2BWW A;  4U6C A;  4B28 A;  1C22 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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