2P9AA

E. coli methionine aminopeptidase dimetalated with inhibitor ye6
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p9aA00
4U75A 2GU7A 3S6BA 5CE6A 3L24A 4FLIA 4A6VA 4U71A 3PKAA 5FCHA 3CB6A 1YW7A 2EA4A 3FMQA 5D6EA 3PKBA 5CDVA 3PKCA 4IF7A 5CLSA 2IW2A 4IU6A 4FLLA 4FUKA 1KQ9A 4U6CA 2GU6A 4FLKA 4MATA 3TAVA 2V3YA 4ZWUA 2BWTA 4B28A 2G6PA 1QXYA 4ZWPA 2Q93A 3BITA 2ZSGA 2GA2A 3BIQA 2BWSA 1YW8A 4S2RP 1YW9A 5CIKA 4EGEA 1XGNA 2GG0A 2BN7A 3FM3A 2Q95A 2V6CA 1R58A 1C27A 1WN1A 1WL9A 2BWWA 2GG3A 4IECA 4U76A 4A6WA 4OOKA 2MATA 2EVCA 1O0XA 2HOWA 4FO8A 4U6WA 1WBQA 4U6JA 4S00A 4ZNGA 3L7GA 3RVAA 2B3HA 2GG5A 1W7VA 3D27A 5CNXA 5D6FA 3PKEA 1M35A 1WL6A 2GGBA 2Q96A 3CTZA 2BHCA 4U6EA 4U73A 4U69A 2GZ5A 4U6ZA 3IU7A 3MATA 3BIPA 1QXWA 2GG7A 3FMRA 3TB5A 4IKUA 1PV9A 2P9AA 1C22A 2EVMA 5FCFA 2BWXA 3Q6DA 1C21A 4FLJA 2BWVA 4FKCA 2GTXA 3MR1A 1A16A 1XNZA 3IU8A 2DFIA 4IPAA 2BWUA 2B3KA 1N51A 4IKRA 2BH3A 4S01A 5JFRA 4QR8A 1XGSA 2GG9A 4IDYA 2Q8KA 4PV4A 2GG8A 2OAZA 1R5HA 1YVMA 2BHDA 2Q92A 4U1BA 2NQ6A 2EVOA 3IU9A 1KP0A 1JAWA 4U70A 1B6AA 4RZZA 3CB5A 5JI6A 2BHBA 2Q94A 1BN5A 2BB7A 2GU4A 4RZYA 4ZWOA 2BHAA 2P98A 1CHMA 5JHUA 1WY2A 3IG4A 1Y1NA 2NQ7A 4Z7MA 1C24A 1B59A 5CDEA 1KQ0A 4HXXA 4RGZ1 5E5BA 2EA2A 1MATA 2BWYA 4S2TP 1YJ3A 3PKDA 1QZYA 1R5GA 1WLRA 1C23A 2ADUA 2B3LA 2GGCA 2V3XA 1QXZA 5CDLA 1W2MA 2P99A 2V3ZA 4R60A 4IKTA 4IKSA 2GU5A 4PNCA 3MX6A 1WKMA 2OKNA 4KM3A 1BOAA 2GG2A 1XGOA 1XGMA 3RORA 4JUQA 4FO7A
chains in the Genus database with same CATH superfamily
4U75A 2GU7A 3S6BA 5CE6A 3L24A 4FLIA 4A6VA 4U71A 3PKAA 5FCHA 3CB6A 1YW7A 2EA4A 3FMQA 5D6EA 3PKBA 5CDVA 3PKCA 4IF7A 5CLSA 2IW2A 4IU6A 4FLLA 4FUKA 1KQ9A 4U6CA 2GU6A 4FLKA 4MATA 3TAVA 2V3YA 4ZWUA 2BWTA 4B28A 2G6PA 1QXYA 4ZWPA 2Q93A 3BITA 2ZSGA 2GA2A 3BIQA 2BWSA 1YW8A 4S2RP 1YW9A 5CIKA 4EGEA 1XGNA 2GG0A 2BN7A 3FM3A 2Q95A 2V6CA 1R58A 1C27A 1WN1A 1WL9A 2BWWA 2GG3A 4IECA 4U76A 4A6WA 4OOKA 2MATA 2EVCA 1O0XA 2HOWA 4FO8A 4U6WA 1WBQA 4U6JA 4S00A 4ZNGA 3L7GA 3RVAA 2B3HA 2GG5A 1W7VA 3D27A 5CNXA 5D6FA 3PKEA 1M35A 1WL6A 2GGBA 2Q96A 3CTZA 2BHCA 4U6EA 4U73A 4U69A 2GZ5A 4U6ZA 3IU7A 3MATA 3BIPA 1QXWA 2GG7A 3FMRA 3TB5A 4IKUA 1PV9A 2P9AA 1C22A 2EVMA 5FCFA 2BWXA 3Q6DA 1C21A 4FLJA 2BWVA 4FKCA 2GTXA 3MR1A 1A16A 1XNZA 3IU8A 2DFIA 4IPAA 2BWUA 2B3KA 1N51A 4IKRA 2BH3A 4S01A 5JFRA 4QR8A 1XGSA 2GG9A 4IDYA 2Q8KA 4PV4A 2GG8A 2OAZA 1R5HA 1YVMA 2BHDA 2Q92A 4U1BA 2NQ6A 2EVOA 3IU9A 1KP0A 1JAWA 4U70A 1B6AA 4RZZA 3CB5A 5JI6A 2BHBA 2Q94A 1BN5A 2BB7A 2GU4A 4RZYA 4ZWOA 2BHAA 2P98A 1CHMA 5JHUA 1WY2A 3IG4A 1Y1NA 2NQ7A 4Z7MA 1C24A 1B59A 5CDEA 1KQ0A 4HXXA 4RGZ1 5E5BA 2EA2A 1MATA 2BWYA 4S2TP 1YJ3A 3PKDA 1QZYA 1R5GA 1WLRA 1C23A 2ADUA 2B3LA 2GGCA 2V3XA 1QXZA 5CDLA 1W2MA 2P99A 2V3ZA 4R60A 4IKTA 4IKSA 2GU5A 4PNCA 3MX6A 1WKMA 2OKNA 4KM3A 1BOAA 2GG2A 1XGOA 1XGMA 3RORA 4JUQA 4FO7A
chains in the Genus database with same CATH topology
4U75A 2GU7A 3S6BA 5CE6A 3L24A 4FLIA 4A6VA 4U71A 3PKAA 5FCHA 3CB6A 1YW7A 2EA4A 3FMQA 5D6EA 3PKBA 5CDVA 3PKCA 4IF7A 5CLSA 2IW2A 4IU6A 4FLLA 4FUKA 1KQ9A 4U6CA 2GU6A 4FLKA 4MATA 3TAVA 2V3YA 4ZWUA 2BWTA 4B28A 2G6PA 1QXYA 4ZWPA 2Q93A 3BITA 2ZSGA 2GA2A 3BIQA 2BWSA 1YW8A 4S2RP 1YW9A 5CIKA 4EGEA 1XGNA 2GG0A 2BN7A 3FM3A 2Q95A 2V6CA 1R58A 1C27A 1WN1A 1WL9A 2BWWA 2GG3A 4IECA 4U76A 4A6WA 4OOKA 2MATA 2EVCA 1O0XA 2HOWA 4FO8A 4U6WA 1WBQA 4U6JA 4S00A 4ZNGA 3L7GA 3RVAA 2B3HA 2GG5A 1W7VA 3D27A 5CNXA 5D6FA 3PKEA 1M35A 1WL6A 2GGBA 2Q96A 3CTZA 2BHCA 4U6EA 4U73A 4U69A 2GZ5A 4U6ZA 3IU7A 3MATA 3BIPA 1QXWA 2GG7A 3FMRA 3TB5A 4IKUA 1PV9A 2P9AA 1C22A 2EVMA 5FCFA 2BWXA 3Q6DA 1C21A 4FLJA 2BWVA 4FKCA 2GTXA 3MR1A 1A16A 1XNZA 3IU8A 2DFIA 4IPAA 2BWUA 2B3KA 1N51A 4IKRA 2BH3A 4S01A 5JFRA 4QR8A 1XGSA 2GG9A 4IDYA 2Q8KA 4PV4A 2GG8A 2OAZA 1R5HA 1YVMA 2BHDA 2Q92A 4U1BA 2NQ6A 2EVOA 3IU9A 1KP0A 1JAWA 4U70A 1B6AA 4RZZA 3CB5A 5JI6A 2BHBA 2Q94A 1BN5A 2BB7A 2GU4A 4RZYA 4ZWOA 2BHAA 2P98A 1CHMA 5JHUA 1WY2A 3IG4A 1Y1NA 2NQ7A 4Z7MA 1C24A 1B59A 5CDEA 1KQ0A 4HXXA 4RGZ1 5E5BA 2EA2A 1MATA 2BWYA 4S2TP 1YJ3A 3PKDA 1QZYA 1R5GA 1WLRA 1C23A 2ADUA 2B3LA 2GGCA 2V3XA 1QXZA 5CDLA 1W2MA 2P99A 2V3ZA 4R60A 4IKTA 4IKSA 2GU5A 4PNCA 3MX6A 1WKMA 2OKNA 4KM3A 1BOAA 2GG2A 1XGOA 1XGMA 3RORA 4JUQA 4FO7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U75 A;  2GU7 A;  3S6B A;  5CE6 A;  3L24 A;  4FLI A;  4A6V A;  4U71 A;  3PKA A;  5FCH A;  3CB6 A;  1YW7 A;  2EA4 A;  3FMQ A;  5D6E A;  3PKB A;  5CDV A;  3PKC A;  4IF7 A;  5CLS A;  2IW2 A;  4IU6 A;  4FLL A;  4FUK A;  1KQ9 A;  4U6C A;  2GU6 A;  4FLK A;  4MAT A;  3TAV A;  2V3Y A;  4ZWU A;  2BWT A;  4B28 A;  2G6P A;  1QXY A;  4ZWP A;  2Q93 A;  3BIT A;  2ZSG A;  2GA2 A;  3BIQ A;  2BWS A;  1YW8 A;  4S2R P;  1YW9 A;  5CIK A;  4EGE A;  1XGN A;  2GG0 A;  2BN7 A;  3FM3 A;  2Q95 A;  2V6C A;  1R58 A;  1C27 A;  1WN1 A;  1WL9 A;  2BWW A;  2GG3 A;  4IEC A;  4U76 A;  4A6W A;  4OOK A;  2MAT A;  2EVC A;  1O0X A;  2HOW A;  4FO8 A;  4U6W A;  1WBQ A;  4U6J A;  4S00 A;  4ZNG A;  3L7G A;  3RVA A;  2B3H A;  2GG5 A;  1W7V A;  3D27 A;  5CNX A;  5D6F A;  3PKE A;  1M35 A;  1WL6 A;  2GGB A;  2Q96 A;  3CTZ A;  2BHC A;  4U6E A;  4U73 A;  4U69 A;  2GZ5 A;  4U6Z A;  3IU7 A;  3MAT A;  3BIP A;  1QXW A;  2GG7 A;  3FMR A;  3TB5 A;  4IKU A;  1PV9 A;  2P9A A;  1C22 A;  2EVM A;  5FCF A;  2BWX A;  3Q6D A;  1C21 A;  4FLJ A;  2BWV A;  4FKC A;  2GTX A;  3MR1 A;  1A16 A;  1XNZ A;  3IU8 A;  2DFI A;  4IPA A;  2BWU A;  2B3K A;  1N51 A;  4IKR A;  2BH3 A;  4S01 A;  5JFR A;  4QR8 A;  1XGS A;  2GG9 A;  4IDY A;  2Q8K A;  4PV4 A;  2GG8 A;  2OAZ A;  1R5H A;  1YVM A;  2BHD A;  2Q92 A;  4U1B A;  2NQ6 A;  2EVO A;  3IU9 A;  1KP0 A;  1JAW A;  4U70 A;  1B6A A;  4RZZ A;  3CB5 A;  5JI6 A;  2BHB A;  2Q94 A;  1BN5 A;  2BB7 A;  2GU4 A;  4RZY A;  4ZWO A;  2BHA A;  2P98 A;  1CHM A;  5JHU A;  1WY2 A;  3IG4 A;  1Y1N A;  2NQ7 A;  4Z7M A;  1C24 A;  1B59 A;  5CDE A;  1KQ0 A;  4HXX A;  4RGZ 1;  5E5B A;  2EA2 A;  1MAT A;  2BWY A;  4S2T P;  1YJ3 A;  3PKD A;  1QZY A;  1R5G A;  1WLR A;  1C23 A;  2ADU A;  2B3L A;  2GGC A;  2V3X A;  1QXZ A;  5CDL A;  1W2M A;  2P99 A;  2V3Z A;  4R60 A;  4IKT A;  4IKS A;  2GU5 A;  4PNC A;  3MX6 A;  1WKM A;  2OKN A;  4KM3 A;  1BOA A;  2GG2 A;  1XGO A;  1XGM A;  3ROR A;  4JUQ A;  4FO7 A; 
#chains in the Genus database with same CATH topology
 4U75 A;  2GU7 A;  3S6B A;  5CE6 A;  3L24 A;  4FLI A;  4A6V A;  4U71 A;  3PKA A;  5FCH A;  3CB6 A;  1YW7 A;  2EA4 A;  3FMQ A;  5D6E A;  3PKB A;  5CDV A;  3PKC A;  4IF7 A;  5CLS A;  2IW2 A;  4IU6 A;  4FLL A;  4FUK A;  1KQ9 A;  4U6C A;  2GU6 A;  4FLK A;  4MAT A;  3TAV A;  2V3Y A;  4ZWU A;  2BWT A;  4B28 A;  2G6P A;  1QXY A;  4ZWP A;  2Q93 A;  3BIT A;  2ZSG A;  2GA2 A;  3BIQ A;  2BWS A;  1YW8 A;  4S2R P;  1YW9 A;  5CIK A;  4EGE A;  1XGN A;  2GG0 A;  2BN7 A;  3FM3 A;  2Q95 A;  2V6C A;  1R58 A;  1C27 A;  1WN1 A;  1WL9 A;  2BWW A;  2GG3 A;  4IEC A;  4U76 A;  4A6W A;  4OOK A;  2MAT A;  2EVC A;  1O0X A;  2HOW A;  4FO8 A;  4U6W A;  1WBQ A;  4U6J A;  4S00 A;  4ZNG A;  3L7G A;  3RVA A;  2B3H A;  2GG5 A;  1W7V A;  3D27 A;  5CNX A;  5D6F A;  3PKE A;  1M35 A;  1WL6 A;  2GGB A;  2Q96 A;  3CTZ A;  2BHC A;  4U6E A;  4U73 A;  4U69 A;  2GZ5 A;  4U6Z A;  3IU7 A;  3MAT A;  3BIP A;  1QXW A;  2GG7 A;  3FMR A;  3TB5 A;  4IKU A;  1PV9 A;  2P9A A;  1C22 A;  2EVM A;  5FCF A;  2BWX A;  3Q6D A;  1C21 A;  4FLJ A;  2BWV A;  4FKC A;  2GTX A;  3MR1 A;  1A16 A;  1XNZ A;  3IU8 A;  2DFI A;  4IPA A;  2BWU A;  2B3K A;  1N51 A;  4IKR A;  2BH3 A;  4S01 A;  5JFR A;  4QR8 A;  1XGS A;  2GG9 A;  4IDY A;  2Q8K A;  4PV4 A;  2GG8 A;  2OAZ A;  1R5H A;  1YVM A;  2BHD A;  2Q92 A;  4U1B A;  2NQ6 A;  2EVO A;  3IU9 A;  1KP0 A;  1JAW A;  4U70 A;  1B6A A;  4RZZ A;  3CB5 A;  5JI6 A;  2BHB A;  2Q94 A;  1BN5 A;  2BB7 A;  2GU4 A;  4RZY A;  4ZWO A;  2BHA A;  2P98 A;  1CHM A;  5JHU A;  1WY2 A;  3IG4 A;  1Y1N A;  2NQ7 A;  4Z7M A;  1C24 A;  1B59 A;  5CDE A;  1KQ0 A;  4HXX A;  4RGZ 1;  5E5B A;  2EA2 A;  1MAT A;  2BWY A;  4S2T P;  1YJ3 A;  3PKD A;  1QZY A;  1R5G A;  1WLR A;  1C23 A;  2ADU A;  2B3L A;  2GGC A;  2V3X A;  1QXZ A;  5CDL A;  1W2M A;  2P99 A;  2V3Z A;  4R60 A;  4IKT A;  4IKS A;  2GU5 A;  4PNC A;  3MX6 A;  1WKM A;  2OKN A;  4KM3 A;  1BOA A;  2GG2 A;  1XGO A;  1XGM A;  3ROR A;  4JUQ A;  4FO7 A; 
#chains in the Genus database with same CATH homology
 4U75 A;  2GU7 A;  3S6B A;  5CE6 A;  3L24 A;  4FLI A;  4A6V A;  4U71 A;  3PKA A;  5FCH A;  3CB6 A;  1YW7 A;  2EA4 A;  3FMQ A;  5D6E A;  3PKB A;  5CDV A;  3PKC A;  4IF7 A;  5CLS A;  2IW2 A;  4IU6 A;  4FLL A;  4FUK A;  1KQ9 A;  4U6C A;  2GU6 A;  4FLK A;  4MAT A;  3TAV A;  2V3Y A;  4ZWU A;  2BWT A;  4B28 A;  2G6P A;  1QXY A;  4ZWP A;  2Q93 A;  3BIT A;  2ZSG A;  2GA2 A;  3BIQ A;  2BWS A;  1YW8 A;  4S2R P;  1YW9 A;  5CIK A;  4EGE A;  1XGN A;  2GG0 A;  2BN7 A;  3FM3 A;  2Q95 A;  2V6C A;  1R58 A;  1C27 A;  1WN1 A;  1WL9 A;  2BWW A;  2GG3 A;  4IEC A;  4U76 A;  4A6W A;  4OOK A;  2MAT A;  2EVC A;  1O0X A;  2HOW A;  4FO8 A;  4U6W A;  1WBQ A;  4U6J A;  4S00 A;  4ZNG A;  3L7G A;  3RVA A;  2B3H A;  2GG5 A;  1W7V A;  3D27 A;  5CNX A;  5D6F A;  3PKE A;  1M35 A;  1WL6 A;  2GGB A;  2Q96 A;  3CTZ A;  2BHC A;  4U6E A;  4U73 A;  4U69 A;  2GZ5 A;  4U6Z A;  3IU7 A;  3MAT A;  3BIP A;  1QXW A;  2GG7 A;  3FMR A;  3TB5 A;  4IKU A;  1PV9 A;  2P9A A;  1C22 A;  2EVM A;  5FCF A;  2BWX A;  3Q6D A;  1C21 A;  4FLJ A;  2BWV A;  4FKC A;  2GTX A;  3MR1 A;  1A16 A;  1XNZ A;  3IU8 A;  2DFI A;  4IPA A;  2BWU A;  2B3K A;  1N51 A;  4IKR A;  2BH3 A;  4S01 A;  5JFR A;  4QR8 A;  1XGS A;  2GG9 A;  4IDY A;  2Q8K A;  4PV4 A;  2GG8 A;  2OAZ A;  1R5H A;  1YVM A;  2BHD A;  2Q92 A;  4U1B A;  2NQ6 A;  2EVO A;  3IU9 A;  1KP0 A;  1JAW A;  4U70 A;  1B6A A;  4RZZ A;  3CB5 A;  5JI6 A;  2BHB A;  2Q94 A;  1BN5 A;  2BB7 A;  2GU4 A;  4RZY A;  4ZWO A;  2BHA A;  2P98 A;  1CHM A;  5JHU A;  1WY2 A;  3IG4 A;  1Y1N A;  2NQ7 A;  4Z7M A;  1C24 A;  1B59 A;  5CDE A;  1KQ0 A;  4HXX A;  4RGZ 1;  5E5B A;  2EA2 A;  1MAT A;  2BWY A;  4S2T P;  1YJ3 A;  3PKD A;  1QZY A;  1R5G A;  1WLR A;  1C23 A;  2ADU A;  2B3L A;  2GGC A;  2V3X A;  1QXZ A;  5CDL A;  1W2M A;  2P99 A;  2V3Z A;  4R60 A;  4IKT A;  4IKS A;  2GU5 A;  4PNC A;  3MX6 A;  1WKM A;  2OKN A;  4KM3 A;  1BOA A;  2GG2 A;  1XGO A;  1XGM A;  3ROR A;  4JUQ A;  4FO7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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