2Q92A

E. coli methionine aminopeptidase mn-form with inhibitor b23
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 84
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q92A00
1WL6A 1PV9A 3IU7A 1M35A 1YW8A 1YW9A 2GU7A 3MX6A 4QR8A 5FCFA 1QXYA 3BIPA 2BHCA 4U6WA 5CLSA 1W7VA 2B3LA 2GG5A 2B3HA 2OKNA 3L7GA 1QZYA 5CDEA 2MATA 4IKSA 2BB7A 4JUQA 2BWTA 4B28A 3MATA 4ZWPA 2GGCA 1A16A 2NQ7A 2GGBA 1MATA 4U6CA 4FUKA 3RVAA 3CTZA 3FMQA 3PKDA 1WL9A 1WKMA 1O0XA 2ADUA 3PKCA 1B59A 4U6ZA 5JHUA 2Q92A 3IU8A 5JFRA 1XGMA 2BWYA 5CIKA 2GTXA 3BITA 4IKRA 1KP0A 3Q6DA 2Q96A 5D6EA 4U69A 2GA2A 2V3XA 4Z7MA 2G6PA 1WLRA 4S2RP 2GG7A 2GU5A 1C24A 1CHMA 1W2MA 4FLJA 4S01A 1XGNA 1BN5A 2GG3A 4RZYA 3RORA 4A6WA 1C22A 2DFIA 1BOAA 3FM3A 4IPAA 1C27A 4U6EA 3IG4A 1N51A 4FKCA 2GG8A 2BHDA 1YW7A 4U76A 4FO7A 2BWVA 2P9AA 4U73A 4HXXA 5D6FA 2P98A 2BWSA 5E5BA 3TAVA 3PKBA 1WN1A 1XGOA 2GG2A 2GU4A 4EGEA 2V3YA 1Y1NA 4ZWOA 3TB5A 4FO8A 4IKTA 1R5GA 4U70A 4OOKA 4U75A 3MR1A 2OAZA 4U6JA 2BWWA 2ZSGA 5CDVA 5FCHA 3PKEA 2GG9A 4FLLA 3L24A 4MATA 1C23A 1YJ3A 3D27A 3IU9A 2HOWA 2BHAA 1C21A 4RGZ1 4S00A 3PKAA 2IW2A 2EVMA 2GU6A 2BN7A 2NQ6A 2EA4A 1R5HA 1QXZA 4PV4A 2EVCA 1KQ0A 2P99A 4S2TP 5JI6A 2V3ZA 4U71A 3CB6A 5CE6A 4IDYA 1WY2A 4IKUA 1WBQA 1R58A 4IECA 2GZ5A 5CDLA 2Q93A 4PNCA 4FLIA 2Q94A 3BIQA 2BHBA 3FMRA 1YVMA 3CB5A 2EA2A 2EVOA 2Q8KA 4A6VA 4U1BA 2BWXA 4RZZA 1XGSA 4IF7A 3S6BA 1QXWA 2BWUA 4FLKA 1JAWA 4ZNGA 2V6CA 1KQ9A 4KM3A 5CNXA 4IU6A 4ZWUA 1B6AA 4R60A 2BH3A 2GG0A 1XNZA 2B3KA 2Q95A
chains in the Genus database with same CATH superfamily
1WL6A 1PV9A 3IU7A 1M35A 1YW8A 1YW9A 2GU7A 3MX6A 4QR8A 5FCFA 1QXYA 3BIPA 2BHCA 4U6WA 5CLSA 1W7VA 2B3LA 2GG5A 2B3HA 2OKNA 3L7GA 1QZYA 5CDEA 2MATA 4IKSA 2BB7A 4JUQA 2BWTA 4B28A 3MATA 4ZWPA 2GGCA 1A16A 2NQ7A 2GGBA 1MATA 4U6CA 4FUKA 3RVAA 3CTZA 3FMQA 3PKDA 1WL9A 1WKMA 1O0XA 2ADUA 3PKCA 1B59A 4U6ZA 5JHUA 2Q92A 3IU8A 5JFRA 1XGMA 2BWYA 5CIKA 2GTXA 3BITA 4IKRA 1KP0A 3Q6DA 2Q96A 5D6EA 4U69A 2GA2A 2V3XA 4Z7MA 2G6PA 1WLRA 4S2RP 2GG7A 2GU5A 1C24A 1CHMA 1W2MA 4FLJA 4S01A 1XGNA 1BN5A 2GG3A 4RZYA 3RORA 4A6WA 1C22A 2DFIA 1BOAA 3FM3A 4IPAA 1C27A 4U6EA 3IG4A 1N51A 4FKCA 2GG8A 2BHDA 1YW7A 4U76A 4FO7A 2BWVA 2P9AA 4U73A 4HXXA 5D6FA 2P98A 2BWSA 5E5BA 3TAVA 3PKBA 1WN1A 1XGOA 2GG2A 2GU4A 4EGEA 2V3YA 1Y1NA 4ZWOA 3TB5A 4FO8A 4IKTA 1R5GA 4U70A 4OOKA 4U75A 3MR1A 2OAZA 4U6JA 2BWWA 2ZSGA 5CDVA 5FCHA 3PKEA 2GG9A 4FLLA 3L24A 4MATA 1C23A 1YJ3A 3D27A 3IU9A 2HOWA 2BHAA 1C21A 4RGZ1 4S00A 3PKAA 2IW2A 2EVMA 2GU6A 2BN7A 2NQ6A 2EA4A 1R5HA 1QXZA 4PV4A 2EVCA 1KQ0A 2P99A 4S2TP 5JI6A 2V3ZA 4U71A 3CB6A 5CE6A 4IDYA 1WY2A 4IKUA 1WBQA 1R58A 4IECA 2GZ5A 5CDLA 2Q93A 4PNCA 4FLIA 2Q94A 3BIQA 2BHBA 3FMRA 1YVMA 3CB5A 2EA2A 2EVOA 2Q8KA 4A6VA 4U1BA 2BWXA 4RZZA 1XGSA 4IF7A 3S6BA 1QXWA 2BWUA 4FLKA 1JAWA 4ZNGA 2V6CA 1KQ9A 4KM3A 5CNXA 4IU6A 4ZWUA 1B6AA 4R60A 2BH3A 2GG0A 1XNZA 2B3KA 2Q95A
chains in the Genus database with same CATH topology
1WL6A 1PV9A 3IU7A 1M35A 1YW8A 1YW9A 2GU7A 3MX6A 4QR8A 5FCFA 1QXYA 3BIPA 2BHCA 4U6WA 5CLSA 1W7VA 2B3LA 2GG5A 2B3HA 2OKNA 3L7GA 1QZYA 5CDEA 2MATA 4IKSA 2BB7A 4JUQA 2BWTA 4B28A 3MATA 4ZWPA 2GGCA 1A16A 2NQ7A 2GGBA 1MATA 4U6CA 4FUKA 3RVAA 3CTZA 3FMQA 3PKDA 1WL9A 1WKMA 1O0XA 2ADUA 3PKCA 1B59A 4U6ZA 5JHUA 2Q92A 3IU8A 5JFRA 1XGMA 2BWYA 5CIKA 2GTXA 3BITA 4IKRA 1KP0A 3Q6DA 2Q96A 5D6EA 4U69A 2GA2A 2V3XA 4Z7MA 2G6PA 1WLRA 4S2RP 2GG7A 2GU5A 1C24A 1CHMA 1W2MA 4FLJA 4S01A 1XGNA 1BN5A 2GG3A 4RZYA 3RORA 4A6WA 1C22A 2DFIA 1BOAA 3FM3A 4IPAA 1C27A 4U6EA 3IG4A 1N51A 4FKCA 2GG8A 2BHDA 1YW7A 4U76A 4FO7A 2BWVA 2P9AA 4U73A 4HXXA 5D6FA 2P98A 2BWSA 5E5BA 3TAVA 3PKBA 1WN1A 1XGOA 2GG2A 2GU4A 4EGEA 2V3YA 1Y1NA 4ZWOA 3TB5A 4FO8A 4IKTA 1R5GA 4U70A 4OOKA 4U75A 3MR1A 2OAZA 4U6JA 2BWWA 2ZSGA 5CDVA 5FCHA 3PKEA 2GG9A 4FLLA 3L24A 4MATA 1C23A 1YJ3A 3D27A 3IU9A 2HOWA 2BHAA 1C21A 4RGZ1 4S00A 3PKAA 2IW2A 2EVMA 2GU6A 2BN7A 2NQ6A 2EA4A 1R5HA 1QXZA 4PV4A 2EVCA 1KQ0A 2P99A 4S2TP 5JI6A 2V3ZA 4U71A 3CB6A 5CE6A 4IDYA 1WY2A 4IKUA 1WBQA 1R58A 4IECA 2GZ5A 5CDLA 2Q93A 4PNCA 4FLIA 2Q94A 3BIQA 2BHBA 3FMRA 1YVMA 3CB5A 2EA2A 2EVOA 2Q8KA 4A6VA 4U1BA 2BWXA 4RZZA 1XGSA 4IF7A 3S6BA 1QXWA 2BWUA 4FLKA 1JAWA 4ZNGA 2V6CA 1KQ9A 4KM3A 5CNXA 4IU6A 4ZWUA 1B6AA 4R60A 2BH3A 2GG0A 1XNZA 2B3KA 2Q95A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WL6 A;  1PV9 A;  3IU7 A;  1M35 A;  1YW8 A;  1YW9 A;  2GU7 A;  3MX6 A;  4QR8 A;  5FCF A;  1QXY A;  3BIP A;  2BHC A;  4U6W A;  5CLS A;  1W7V A;  2B3L A;  2GG5 A;  2B3H A;  2OKN A;  3L7G A;  1QZY A;  5CDE A;  2MAT A;  4IKS A;  2BB7 A;  4JUQ A;  2BWT A;  4B28 A;  3MAT A;  4ZWP A;  2GGC A;  1A16 A;  2NQ7 A;  2GGB A;  1MAT A;  4U6C A;  4FUK A;  3RVA A;  3CTZ A;  3FMQ A;  3PKD A;  1WL9 A;  1WKM A;  1O0X A;  2ADU A;  3PKC A;  1B59 A;  4U6Z A;  5JHU A;  2Q92 A;  3IU8 A;  5JFR A;  1XGM A;  2BWY A;  5CIK A;  2GTX A;  3BIT A;  4IKR A;  1KP0 A;  3Q6D A;  2Q96 A;  5D6E A;  4U69 A;  2GA2 A;  2V3X A;  4Z7M A;  2G6P A;  1WLR A;  4S2R P;  2GG7 A;  2GU5 A;  1C24 A;  1CHM A;  1W2M A;  4FLJ A;  4S01 A;  1XGN A;  1BN5 A;  2GG3 A;  4RZY A;  3ROR A;  4A6W A;  1C22 A;  2DFI A;  1BOA A;  3FM3 A;  4IPA A;  1C27 A;  4U6E A;  3IG4 A;  1N51 A;  4FKC A;  2GG8 A;  2BHD A;  1YW7 A;  4U76 A;  4FO7 A;  2BWV A;  2P9A A;  4U73 A;  4HXX A;  5D6F A;  2P98 A;  2BWS A;  5E5B A;  3TAV A;  3PKB A;  1WN1 A;  1XGO A;  2GG2 A;  2GU4 A;  4EGE A;  2V3Y A;  1Y1N A;  4ZWO A;  3TB5 A;  4FO8 A;  4IKT A;  1R5G A;  4U70 A;  4OOK A;  4U75 A;  3MR1 A;  2OAZ A;  4U6J A;  2BWW A;  2ZSG A;  5CDV A;  5FCH A;  3PKE A;  2GG9 A;  4FLL A;  3L24 A;  4MAT A;  1C23 A;  1YJ3 A;  3D27 A;  3IU9 A;  2HOW A;  2BHA A;  1C21 A;  4RGZ 1;  4S00 A;  3PKA A;  2IW2 A;  2EVM A;  2GU6 A;  2BN7 A;  2NQ6 A;  2EA4 A;  1R5H A;  1QXZ A;  4PV4 A;  2EVC A;  1KQ0 A;  2P99 A;  4S2T P;  5JI6 A;  2V3Z A;  4U71 A;  3CB6 A;  5CE6 A;  4IDY A;  1WY2 A;  4IKU A;  1WBQ A;  1R58 A;  4IEC A;  2GZ5 A;  5CDL A;  2Q93 A;  4PNC A;  4FLI A;  2Q94 A;  3BIQ A;  2BHB A;  3FMR A;  1YVM A;  3CB5 A;  2EA2 A;  2EVO A;  2Q8K A;  4A6V A;  4U1B A;  2BWX A;  4RZZ A;  1XGS A;  4IF7 A;  3S6B A;  1QXW A;  2BWU A;  4FLK A;  1JAW A;  4ZNG A;  2V6C A;  1KQ9 A;  4KM3 A;  5CNX A;  4IU6 A;  4ZWU A;  1B6A A;  4R60 A;  2BH3 A;  2GG0 A;  1XNZ A;  2B3K A;  2Q95 A; 
#chains in the Genus database with same CATH topology
 1WL6 A;  1PV9 A;  3IU7 A;  1M35 A;  1YW8 A;  1YW9 A;  2GU7 A;  3MX6 A;  4QR8 A;  5FCF A;  1QXY A;  3BIP A;  2BHC A;  4U6W A;  5CLS A;  1W7V A;  2B3L A;  2GG5 A;  2B3H A;  2OKN A;  3L7G A;  1QZY A;  5CDE A;  2MAT A;  4IKS A;  2BB7 A;  4JUQ A;  2BWT A;  4B28 A;  3MAT A;  4ZWP A;  2GGC A;  1A16 A;  2NQ7 A;  2GGB A;  1MAT A;  4U6C A;  4FUK A;  3RVA A;  3CTZ A;  3FMQ A;  3PKD A;  1WL9 A;  1WKM A;  1O0X A;  2ADU A;  3PKC A;  1B59 A;  4U6Z A;  5JHU A;  2Q92 A;  3IU8 A;  5JFR A;  1XGM A;  2BWY A;  5CIK A;  2GTX A;  3BIT A;  4IKR A;  1KP0 A;  3Q6D A;  2Q96 A;  5D6E A;  4U69 A;  2GA2 A;  2V3X A;  4Z7M A;  2G6P A;  1WLR A;  4S2R P;  2GG7 A;  2GU5 A;  1C24 A;  1CHM A;  1W2M A;  4FLJ A;  4S01 A;  1XGN A;  1BN5 A;  2GG3 A;  4RZY A;  3ROR A;  4A6W A;  1C22 A;  2DFI A;  1BOA A;  3FM3 A;  4IPA A;  1C27 A;  4U6E A;  3IG4 A;  1N51 A;  4FKC A;  2GG8 A;  2BHD A;  1YW7 A;  4U76 A;  4FO7 A;  2BWV A;  2P9A A;  4U73 A;  4HXX A;  5D6F A;  2P98 A;  2BWS A;  5E5B A;  3TAV A;  3PKB A;  1WN1 A;  1XGO A;  2GG2 A;  2GU4 A;  4EGE A;  2V3Y A;  1Y1N A;  4ZWO A;  3TB5 A;  4FO8 A;  4IKT A;  1R5G A;  4U70 A;  4OOK A;  4U75 A;  3MR1 A;  2OAZ A;  4U6J A;  2BWW A;  2ZSG A;  5CDV A;  5FCH A;  3PKE A;  2GG9 A;  4FLL A;  3L24 A;  4MAT A;  1C23 A;  1YJ3 A;  3D27 A;  3IU9 A;  2HOW A;  2BHA A;  1C21 A;  4RGZ 1;  4S00 A;  3PKA A;  2IW2 A;  2EVM A;  2GU6 A;  2BN7 A;  2NQ6 A;  2EA4 A;  1R5H A;  1QXZ A;  4PV4 A;  2EVC A;  1KQ0 A;  2P99 A;  4S2T P;  5JI6 A;  2V3Z A;  4U71 A;  3CB6 A;  5CE6 A;  4IDY A;  1WY2 A;  4IKU A;  1WBQ A;  1R58 A;  4IEC A;  2GZ5 A;  5CDL A;  2Q93 A;  4PNC A;  4FLI A;  2Q94 A;  3BIQ A;  2BHB A;  3FMR A;  1YVM A;  3CB5 A;  2EA2 A;  2EVO A;  2Q8K A;  4A6V A;  4U1B A;  2BWX A;  4RZZ A;  1XGS A;  4IF7 A;  3S6B A;  1QXW A;  2BWU A;  4FLK A;  1JAW A;  4ZNG A;  2V6C A;  1KQ9 A;  4KM3 A;  5CNX A;  4IU6 A;  4ZWU A;  1B6A A;  4R60 A;  2BH3 A;  2GG0 A;  1XNZ A;  2B3K A;  2Q95 A; 
#chains in the Genus database with same CATH homology
 1WL6 A;  1PV9 A;  3IU7 A;  1M35 A;  1YW8 A;  1YW9 A;  2GU7 A;  3MX6 A;  4QR8 A;  5FCF A;  1QXY A;  3BIP A;  2BHC A;  4U6W A;  5CLS A;  1W7V A;  2B3L A;  2GG5 A;  2B3H A;  2OKN A;  3L7G A;  1QZY A;  5CDE A;  2MAT A;  4IKS A;  2BB7 A;  4JUQ A;  2BWT A;  4B28 A;  3MAT A;  4ZWP A;  2GGC A;  1A16 A;  2NQ7 A;  2GGB A;  1MAT A;  4U6C A;  4FUK A;  3RVA A;  3CTZ A;  3FMQ A;  3PKD A;  1WL9 A;  1WKM A;  1O0X A;  2ADU A;  3PKC A;  1B59 A;  4U6Z A;  5JHU A;  2Q92 A;  3IU8 A;  5JFR A;  1XGM A;  2BWY A;  5CIK A;  2GTX A;  3BIT A;  4IKR A;  1KP0 A;  3Q6D A;  2Q96 A;  5D6E A;  4U69 A;  2GA2 A;  2V3X A;  4Z7M A;  2G6P A;  1WLR A;  4S2R P;  2GG7 A;  2GU5 A;  1C24 A;  1CHM A;  1W2M A;  4FLJ A;  4S01 A;  1XGN A;  1BN5 A;  2GG3 A;  4RZY A;  3ROR A;  4A6W A;  1C22 A;  2DFI A;  1BOA A;  3FM3 A;  4IPA A;  1C27 A;  4U6E A;  3IG4 A;  1N51 A;  4FKC A;  2GG8 A;  2BHD A;  1YW7 A;  4U76 A;  4FO7 A;  2BWV A;  2P9A A;  4U73 A;  4HXX A;  5D6F A;  2P98 A;  2BWS A;  5E5B A;  3TAV A;  3PKB A;  1WN1 A;  1XGO A;  2GG2 A;  2GU4 A;  4EGE A;  2V3Y A;  1Y1N A;  4ZWO A;  3TB5 A;  4FO8 A;  4IKT A;  1R5G A;  4U70 A;  4OOK A;  4U75 A;  3MR1 A;  2OAZ A;  4U6J A;  2BWW A;  2ZSG A;  5CDV A;  5FCH A;  3PKE A;  2GG9 A;  4FLL A;  3L24 A;  4MAT A;  1C23 A;  1YJ3 A;  3D27 A;  3IU9 A;  2HOW A;  2BHA A;  1C21 A;  4RGZ 1;  4S00 A;  3PKA A;  2IW2 A;  2EVM A;  2GU6 A;  2BN7 A;  2NQ6 A;  2EA4 A;  1R5H A;  1QXZ A;  4PV4 A;  2EVC A;  1KQ0 A;  2P99 A;  4S2T P;  5JI6 A;  2V3Z A;  4U71 A;  3CB6 A;  5CE6 A;  4IDY A;  1WY2 A;  4IKU A;  1WBQ A;  1R58 A;  4IEC A;  2GZ5 A;  5CDL A;  2Q93 A;  4PNC A;  4FLI A;  2Q94 A;  3BIQ A;  2BHB A;  3FMR A;  1YVM A;  3CB5 A;  2EA2 A;  2EVO A;  2Q8K A;  4A6V A;  4U1B A;  2BWX A;  4RZZ A;  1XGS A;  4IF7 A;  3S6B A;  1QXW A;  2BWU A;  4FLK A;  1JAW A;  4ZNG A;  2V6C A;  1KQ9 A;  4KM3 A;  5CNX A;  4IU6 A;  4ZWU A;  1B6A A;  4R60 A;  2BH3 A;  2GG0 A;  1XNZ A;  2B3K A;  2Q95 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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