2Q93A

E. coli methionine aminopeptidase mn-form with inhibitor b21
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of inhibition of E. coli methionine aminopeptidase: implication of loop flexibility in selective inhibition of bacterial enzymes.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
molecule tags Hydrolase
source organism Escherichia coli
total genus 83
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-06-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2q93A00
1WBQA 1C21A 2GU4A 2P99A 4IECA 2GTXA 2GG9A 4IKTA 4FKCA 1YJ3A 5JI6A 4ZWPA 1YW9A 4IKUA 4U76A 5CDEA 3CTZA 2V3YA 1WKMA 2GG7A 2BHCA 2NQ7A 2P98A 3PKAA 4RZZA 4ZWOA 3FMQA 4S00A 2P9AA 3BITA 2BHAA 2GGCA 1W7VA 1C22A 4A6VA 2Q92A 5JFRA 1MATA 2BN7A 5CNXA 1Y1NA 2BWTA 2GU6A 4S2RP 4EGEA 3RVAA 2HOWA 3L7GA 3IU7A 2BB7A 4PV4A 2B3HA 2MATA 2BWWA 2BWSA 3CB6A 1XGNA 2Q96A 4RGZ1 2DFIA 3BIPA 3PKBA 2Q94A 2BHDA 5FCHA 2GG3A 2BWUA 5FCFA 4IU6A 4MATA 2B3LA 4R60A 4S01A 4IPAA 5D6FA 2NQ6A 1N51A 1M35A 1XNZA 1C24A 4JUQA 5E5BA 4FUKA 4ZWUA 5D6EA 3BIQA 4IKSA 4HXXA 4U6JA 4U73A 3D27A 4FLIA 2GG8A 3IU9A 3MR1A 1R58A 3FMRA 5CIKA 2EA2A 1WL6A 1O0XA 2OAZA 1R5HA 1WL9A 3PKDA 2EA4A 4U75A 4Z7MA 4QR8A 3L24A 4U6EA 3MATA 3TAVA 3IU8A 1W2MA 5CLSA 1QXZA 2V3ZA 4IF7A 4A6WA 3S6BA 4PNCA 2GG5A 1C27A 2GZ5A 1BOAA 1R5GA 3IG4A 2BWYA 4FO7A 4U70A 5CDLA 1QZYA 1WY2A 4U6WA 2ZSGA 2GGBA 4FLLA 2BHBA 4U6CA 1C23A 4ZNGA 1YVMA 1WN1A 1B59A 2GG0A 4FLKA 1YW7A 2EVCA 2Q95A 4U69A 3Q6DA 2GA2A 3PKCA 1XGSA 4IDYA 2BH3A 3TB5A 1A16A 1XGMA 4KM3A 1KP0A 2ADUA 2Q8KA 1KQ9A 3MX6A 1QXYA 2G6PA 5CE6A 2V6CA 1JAWA 3FM3A 2GU7A 4U71A 4U1BA 4B28A 1PV9A 2V3XA 4FLJA 3PKEA 3RORA 4FO8A 5JHUA 2BWVA 2IW2A 5CDVA 4U6ZA 1BN5A 4OOKA 1KQ0A 2BWXA 1B6AA 2EVMA 2GG2A 4S2TP 3CB5A 2OKNA 1CHMA 1WLRA 1XGOA 1QXWA 1YW8A 2EVOA 4IKRA 4RZYA 2GU5A 2B3KA 2Q93A
chains in the Genus database with same CATH superfamily
1WBQA 1C21A 2GU4A 2P99A 4IECA 2GTXA 2GG9A 4IKTA 4FKCA 1YJ3A 5JI6A 4ZWPA 1YW9A 4IKUA 4U76A 5CDEA 3CTZA 2V3YA 1WKMA 2GG7A 2BHCA 2NQ7A 2P98A 3PKAA 4RZZA 4ZWOA 3FMQA 4S00A 2P9AA 3BITA 2BHAA 2GGCA 1W7VA 1C22A 4A6VA 2Q92A 5JFRA 1MATA 2BN7A 5CNXA 1Y1NA 2BWTA 2GU6A 4S2RP 4EGEA 3RVAA 2HOWA 3L7GA 3IU7A 2BB7A 4PV4A 2B3HA 2MATA 2BWWA 2BWSA 3CB6A 1XGNA 2Q96A 4RGZ1 2DFIA 3BIPA 3PKBA 2Q94A 2BHDA 5FCHA 2GG3A 2BWUA 5FCFA 4IU6A 4MATA 2B3LA 4R60A 4S01A 4IPAA 5D6FA 2NQ6A 1N51A 1M35A 1XNZA 1C24A 4JUQA 5E5BA 4FUKA 4ZWUA 5D6EA 3BIQA 4IKSA 4HXXA 4U6JA 4U73A 3D27A 4FLIA 2GG8A 3IU9A 3MR1A 1R58A 3FMRA 5CIKA 2EA2A 1WL6A 1O0XA 2OAZA 1R5HA 1WL9A 3PKDA 2EA4A 4U75A 4Z7MA 4QR8A 3L24A 4U6EA 3MATA 3TAVA 3IU8A 1W2MA 5CLSA 1QXZA 2V3ZA 4IF7A 4A6WA 3S6BA 4PNCA 2GG5A 1C27A 2GZ5A 1BOAA 1R5GA 3IG4A 2BWYA 4FO7A 4U70A 5CDLA 1QZYA 1WY2A 4U6WA 2ZSGA 2GGBA 4FLLA 2BHBA 4U6CA 1C23A 4ZNGA 1YVMA 1WN1A 1B59A 2GG0A 4FLKA 1YW7A 2EVCA 2Q95A 4U69A 3Q6DA 2GA2A 3PKCA 1XGSA 4IDYA 2BH3A 3TB5A 1A16A 1XGMA 4KM3A 1KP0A 2ADUA 2Q8KA 1KQ9A 3MX6A 1QXYA 2G6PA 5CE6A 2V6CA 1JAWA 3FM3A 2GU7A 4U71A 4U1BA 4B28A 1PV9A 2V3XA 4FLJA 3PKEA 3RORA 4FO8A 5JHUA 2BWVA 2IW2A 5CDVA 4U6ZA 1BN5A 4OOKA 1KQ0A 2BWXA 1B6AA 2EVMA 2GG2A 4S2TP 3CB5A 2OKNA 1CHMA 1WLRA 1XGOA 1QXWA 1YW8A 2EVOA 4IKRA 4RZYA 2GU5A 2B3KA 2Q93A
chains in the Genus database with same CATH topology
1WBQA 1C21A 2GU4A 2P99A 4IECA 2GTXA 2GG9A 4IKTA 4FKCA 1YJ3A 5JI6A 4ZWPA 1YW9A 4IKUA 4U76A 5CDEA 3CTZA 2V3YA 1WKMA 2GG7A 2BHCA 2NQ7A 2P98A 3PKAA 4RZZA 4ZWOA 3FMQA 4S00A 2P9AA 3BITA 2BHAA 2GGCA 1W7VA 1C22A 4A6VA 2Q92A 5JFRA 1MATA 2BN7A 5CNXA 1Y1NA 2BWTA 2GU6A 4S2RP 4EGEA 3RVAA 2HOWA 3L7GA 3IU7A 2BB7A 4PV4A 2B3HA 2MATA 2BWWA 2BWSA 3CB6A 1XGNA 2Q96A 4RGZ1 2DFIA 3BIPA 3PKBA 2Q94A 2BHDA 5FCHA 2GG3A 2BWUA 5FCFA 4IU6A 4MATA 2B3LA 4R60A 4S01A 4IPAA 5D6FA 2NQ6A 1N51A 1M35A 1XNZA 1C24A 4JUQA 5E5BA 4FUKA 4ZWUA 5D6EA 3BIQA 4IKSA 4HXXA 4U6JA 4U73A 3D27A 4FLIA 2GG8A 3IU9A 3MR1A 1R58A 3FMRA 5CIKA 2EA2A 1WL6A 1O0XA 2OAZA 1R5HA 1WL9A 3PKDA 2EA4A 4U75A 4Z7MA 4QR8A 3L24A 4U6EA 3MATA 3TAVA 3IU8A 1W2MA 5CLSA 1QXZA 2V3ZA 4IF7A 4A6WA 3S6BA 4PNCA 2GG5A 1C27A 2GZ5A 1BOAA 1R5GA 3IG4A 2BWYA 4FO7A 4U70A 5CDLA 1QZYA 1WY2A 4U6WA 2ZSGA 2GGBA 4FLLA 2BHBA 4U6CA 1C23A 4ZNGA 1YVMA 1WN1A 1B59A 2GG0A 4FLKA 1YW7A 2EVCA 2Q95A 4U69A 3Q6DA 2GA2A 3PKCA 1XGSA 4IDYA 2BH3A 3TB5A 1A16A 1XGMA 4KM3A 1KP0A 2ADUA 2Q8KA 1KQ9A 3MX6A 1QXYA 2G6PA 5CE6A 2V6CA 1JAWA 3FM3A 2GU7A 4U71A 4U1BA 4B28A 1PV9A 2V3XA 4FLJA 3PKEA 3RORA 4FO8A 5JHUA 2BWVA 2IW2A 5CDVA 4U6ZA 1BN5A 4OOKA 1KQ0A 2BWXA 1B6AA 2EVMA 2GG2A 4S2TP 3CB5A 2OKNA 1CHMA 1WLRA 1XGOA 1QXWA 1YW8A 2EVOA 4IKRA 4RZYA 2GU5A 2B3KA 2Q93A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1WBQ A;  1C21 A;  2GU4 A;  2P99 A;  4IEC A;  2GTX A;  2GG9 A;  4IKT A;  4FKC A;  1YJ3 A;  5JI6 A;  4ZWP A;  1YW9 A;  4IKU A;  4U76 A;  5CDE A;  3CTZ A;  2V3Y A;  1WKM A;  2GG7 A;  2BHC A;  2NQ7 A;  2P98 A;  3PKA A;  4RZZ A;  4ZWO A;  3FMQ A;  4S00 A;  2P9A A;  3BIT A;  2BHA A;  2GGC A;  1W7V A;  1C22 A;  4A6V A;  2Q92 A;  5JFR A;  1MAT A;  2BN7 A;  5CNX A;  1Y1N A;  2BWT A;  2GU6 A;  4S2R P;  4EGE A;  3RVA A;  2HOW A;  3L7G A;  3IU7 A;  2BB7 A;  4PV4 A;  2B3H A;  2MAT A;  2BWW A;  2BWS A;  3CB6 A;  1XGN A;  2Q96 A;  4RGZ 1;  2DFI A;  3BIP A;  3PKB A;  2Q94 A;  2BHD A;  5FCH A;  2GG3 A;  2BWU A;  5FCF A;  4IU6 A;  4MAT A;  2B3L A;  4R60 A;  4S01 A;  4IPA A;  5D6F A;  2NQ6 A;  1N51 A;  1M35 A;  1XNZ A;  1C24 A;  4JUQ A;  5E5B A;  4FUK A;  4ZWU A;  5D6E A;  3BIQ A;  4IKS A;  4HXX A;  4U6J A;  4U73 A;  3D27 A;  4FLI A;  2GG8 A;  3IU9 A;  3MR1 A;  1R58 A;  3FMR A;  5CIK A;  2EA2 A;  1WL6 A;  1O0X A;  2OAZ A;  1R5H A;  1WL9 A;  3PKD A;  2EA4 A;  4U75 A;  4Z7M A;  4QR8 A;  3L24 A;  4U6E A;  3MAT A;  3TAV A;  3IU8 A;  1W2M A;  5CLS A;  1QXZ A;  2V3Z A;  4IF7 A;  4A6W A;  3S6B A;  4PNC A;  2GG5 A;  1C27 A;  2GZ5 A;  1BOA A;  1R5G A;  3IG4 A;  2BWY A;  4FO7 A;  4U70 A;  5CDL A;  1QZY A;  1WY2 A;  4U6W A;  2ZSG A;  2GGB A;  4FLL A;  2BHB A;  4U6C A;  1C23 A;  4ZNG A;  1YVM A;  1WN1 A;  1B59 A;  2GG0 A;  4FLK A;  1YW7 A;  2EVC A;  2Q95 A;  4U69 A;  3Q6D A;  2GA2 A;  3PKC A;  1XGS A;  4IDY A;  2BH3 A;  3TB5 A;  1A16 A;  1XGM A;  4KM3 A;  1KP0 A;  2ADU A;  2Q8K A;  1KQ9 A;  3MX6 A;  1QXY A;  2G6P A;  5CE6 A;  2V6C A;  1JAW A;  3FM3 A;  2GU7 A;  4U71 A;  4U1B A;  4B28 A;  1PV9 A;  2V3X A;  4FLJ A;  3PKE A;  3ROR A;  4FO8 A;  5JHU A;  2BWV A;  2IW2 A;  5CDV A;  4U6Z A;  1BN5 A;  4OOK A;  1KQ0 A;  2BWX A;  1B6A A;  2EVM A;  2GG2 A;  4S2T P;  3CB5 A;  2OKN A;  1CHM A;  1WLR A;  1XGO A;  1QXW A;  1YW8 A;  2EVO A;  4IKR A;  4RZY A;  2GU5 A;  2B3K A;  2Q93 A; 
#chains in the Genus database with same CATH topology
 1WBQ A;  1C21 A;  2GU4 A;  2P99 A;  4IEC A;  2GTX A;  2GG9 A;  4IKT A;  4FKC A;  1YJ3 A;  5JI6 A;  4ZWP A;  1YW9 A;  4IKU A;  4U76 A;  5CDE A;  3CTZ A;  2V3Y A;  1WKM A;  2GG7 A;  2BHC A;  2NQ7 A;  2P98 A;  3PKA A;  4RZZ A;  4ZWO A;  3FMQ A;  4S00 A;  2P9A A;  3BIT A;  2BHA A;  2GGC A;  1W7V A;  1C22 A;  4A6V A;  2Q92 A;  5JFR A;  1MAT A;  2BN7 A;  5CNX A;  1Y1N A;  2BWT A;  2GU6 A;  4S2R P;  4EGE A;  3RVA A;  2HOW A;  3L7G A;  3IU7 A;  2BB7 A;  4PV4 A;  2B3H A;  2MAT A;  2BWW A;  2BWS A;  3CB6 A;  1XGN A;  2Q96 A;  4RGZ 1;  2DFI A;  3BIP A;  3PKB A;  2Q94 A;  2BHD A;  5FCH A;  2GG3 A;  2BWU A;  5FCF A;  4IU6 A;  4MAT A;  2B3L A;  4R60 A;  4S01 A;  4IPA A;  5D6F A;  2NQ6 A;  1N51 A;  1M35 A;  1XNZ A;  1C24 A;  4JUQ A;  5E5B A;  4FUK A;  4ZWU A;  5D6E A;  3BIQ A;  4IKS A;  4HXX A;  4U6J A;  4U73 A;  3D27 A;  4FLI A;  2GG8 A;  3IU9 A;  3MR1 A;  1R58 A;  3FMR A;  5CIK A;  2EA2 A;  1WL6 A;  1O0X A;  2OAZ A;  1R5H A;  1WL9 A;  3PKD A;  2EA4 A;  4U75 A;  4Z7M A;  4QR8 A;  3L24 A;  4U6E A;  3MAT A;  3TAV A;  3IU8 A;  1W2M A;  5CLS A;  1QXZ A;  2V3Z A;  4IF7 A;  4A6W A;  3S6B A;  4PNC A;  2GG5 A;  1C27 A;  2GZ5 A;  1BOA A;  1R5G A;  3IG4 A;  2BWY A;  4FO7 A;  4U70 A;  5CDL A;  1QZY A;  1WY2 A;  4U6W A;  2ZSG A;  2GGB A;  4FLL A;  2BHB A;  4U6C A;  1C23 A;  4ZNG A;  1YVM A;  1WN1 A;  1B59 A;  2GG0 A;  4FLK A;  1YW7 A;  2EVC A;  2Q95 A;  4U69 A;  3Q6D A;  2GA2 A;  3PKC A;  1XGS A;  4IDY A;  2BH3 A;  3TB5 A;  1A16 A;  1XGM A;  4KM3 A;  1KP0 A;  2ADU A;  2Q8K A;  1KQ9 A;  3MX6 A;  1QXY A;  2G6P A;  5CE6 A;  2V6C A;  1JAW A;  3FM3 A;  2GU7 A;  4U71 A;  4U1B A;  4B28 A;  1PV9 A;  2V3X A;  4FLJ A;  3PKE A;  3ROR A;  4FO8 A;  5JHU A;  2BWV A;  2IW2 A;  5CDV A;  4U6Z A;  1BN5 A;  4OOK A;  1KQ0 A;  2BWX A;  1B6A A;  2EVM A;  2GG2 A;  4S2T P;  3CB5 A;  2OKN A;  1CHM A;  1WLR A;  1XGO A;  1QXW A;  1YW8 A;  2EVO A;  4IKR A;  4RZY A;  2GU5 A;  2B3K A;  2Q93 A; 
#chains in the Genus database with same CATH homology
 1WBQ A;  1C21 A;  2GU4 A;  2P99 A;  4IEC A;  2GTX A;  2GG9 A;  4IKT A;  4FKC A;  1YJ3 A;  5JI6 A;  4ZWP A;  1YW9 A;  4IKU A;  4U76 A;  5CDE A;  3CTZ A;  2V3Y A;  1WKM A;  2GG7 A;  2BHC A;  2NQ7 A;  2P98 A;  3PKA A;  4RZZ A;  4ZWO A;  3FMQ A;  4S00 A;  2P9A A;  3BIT A;  2BHA A;  2GGC A;  1W7V A;  1C22 A;  4A6V A;  2Q92 A;  5JFR A;  1MAT A;  2BN7 A;  5CNX A;  1Y1N A;  2BWT A;  2GU6 A;  4S2R P;  4EGE A;  3RVA A;  2HOW A;  3L7G A;  3IU7 A;  2BB7 A;  4PV4 A;  2B3H A;  2MAT A;  2BWW A;  2BWS A;  3CB6 A;  1XGN A;  2Q96 A;  4RGZ 1;  2DFI A;  3BIP A;  3PKB A;  2Q94 A;  2BHD A;  5FCH A;  2GG3 A;  2BWU A;  5FCF A;  4IU6 A;  4MAT A;  2B3L A;  4R60 A;  4S01 A;  4IPA A;  5D6F A;  2NQ6 A;  1N51 A;  1M35 A;  1XNZ A;  1C24 A;  4JUQ A;  5E5B A;  4FUK A;  4ZWU A;  5D6E A;  3BIQ A;  4IKS A;  4HXX A;  4U6J A;  4U73 A;  3D27 A;  4FLI A;  2GG8 A;  3IU9 A;  3MR1 A;  1R58 A;  3FMR A;  5CIK A;  2EA2 A;  1WL6 A;  1O0X A;  2OAZ A;  1R5H A;  1WL9 A;  3PKD A;  2EA4 A;  4U75 A;  4Z7M A;  4QR8 A;  3L24 A;  4U6E A;  3MAT A;  3TAV A;  3IU8 A;  1W2M A;  5CLS A;  1QXZ A;  2V3Z A;  4IF7 A;  4A6W A;  3S6B A;  4PNC A;  2GG5 A;  1C27 A;  2GZ5 A;  1BOA A;  1R5G A;  3IG4 A;  2BWY A;  4FO7 A;  4U70 A;  5CDL A;  1QZY A;  1WY2 A;  4U6W A;  2ZSG A;  2GGB A;  4FLL A;  2BHB A;  4U6C A;  1C23 A;  4ZNG A;  1YVM A;  1WN1 A;  1B59 A;  2GG0 A;  4FLK A;  1YW7 A;  2EVC A;  2Q95 A;  4U69 A;  3Q6D A;  2GA2 A;  3PKC A;  1XGS A;  4IDY A;  2BH3 A;  3TB5 A;  1A16 A;  1XGM A;  4KM3 A;  1KP0 A;  2ADU A;  2Q8K A;  1KQ9 A;  3MX6 A;  1QXY A;  2G6P A;  5CE6 A;  2V6C A;  1JAW A;  3FM3 A;  2GU7 A;  4U71 A;  4U1B A;  4B28 A;  1PV9 A;  2V3X A;  4FLJ A;  3PKE A;  3ROR A;  4FO8 A;  5JHU A;  2BWV A;  2IW2 A;  5CDV A;  4U6Z A;  1BN5 A;  4OOK A;  1KQ0 A;  2BWX A;  1B6A A;  2EVM A;  2GG2 A;  4S2T P;  3CB5 A;  2OKN A;  1CHM A;  1WLR A;  1XGO A;  1QXW A;  1YW8 A;  2EVO A;  4IKR A;  4RZY A;  2GU5 A;  2B3K A;  2Q93 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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