2B3KA

Crystal structure of human methionine aminopeptidase type i in the holo form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,).
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-09-20

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2b3kA00
2NQ6A 4EGEA 3PKAA 2BHCA 2V3ZA 2V3YA 2BWWA 1QXYA 1C22A 1XGSA 4A6WA 2HOWA 1KQ0A 1N51A 2EA2A 4RZYA 4A6VA 2GU6A 1B6AA 4U6ZA 4U71A 2GG3A 2G6PA 2GTXA 4FO8A 2BHBA 5CDEA 1C21A 1Y1NA 2ADUA 2BWUA 2Q96A 1XGOA 4FLJA 4ZWOA 3L24A 1MATA 4FKCA 2Q8KA 3CTZA 1YW7A 3TAVA 3FM3A 2GZ5A 4B28A 3IU9A 4Z7MA 1R58A 2BWSA 1W2MA 2GGCA 1QXWA 4IKTA 4U6CA 2BWTA 4RZZA 4ZNGA 2GG2A 1BN5A 2EVOA 5CLSA 2EA4A 1PV9A 2NQ7A 1WL9A 5D6EA 1WN1A 5JFRA 4FO7A 2GA2A 1R5HA 2GG8A 4HXXA 1C23A 2EVCA 3PKCA 1XGNA 1JAWA 2GG9A 4U76A 3IU7A 1C24A 3S6BA 4RGZ1 5FCFA 3MR1A 2IW2A 2GGBA 2BHAA 2OKNA 3MX6A 4OOKA 4U69A 4ZWPA 3BIQA 1YJ3A 1M35A 2GG0A 1WL6A 4U6JA 2BH3A 2EVMA 3FMQA 2GU5A 4S2TP 3TB5A 1YW8A 4U6EA 4IECA 4PV4A 2BWXA 2BB7A 1B59A 4JUQA 1WLRA 1W7VA 4U73A 3IU8A 4R60A 5E5BA 3CB6A 2B3LA 4IDYA 4U70A 1XNZA 2Q93A 1CHMA 2P98A 4IU6A 4IPAA 1A16A 2ZSGA 3IG4A 4S01A 3FMRA 4U75A 1KQ9A 1XGMA 2V6CA 1KP0A 2BWYA 2B3HA 4KM3A 1QZYA 5CDVA 2DFIA 3MATA 4IKUA 4MATA 1QXZA 1O0XA 1WBQA 3PKBA 4S2RP 1BOAA 4QR8A 3CB5A 2OAZA 3D27A 4FUKA 4FLLA 3RORA 5CNXA 2P9AA 1YW9A 3RVAA 5CE6A 1YVMA 2BN7A 1R5GA 1WY2A 2GU7A 1WKMA 5CIKA 3PKDA 2Q95A 4ZWUA 2BWVA 2MATA 2GG7A 4U1BA 4U6WA 4S00A 2P99A 5CDLA 3BITA 1C27A 2V3XA 4IF7A 5D6FA 2Q94A 3Q6DA 5FCHA 3L7GA 4FLIA 4PNCA 4FLKA 4IKSA 5JHUA 2Q92A 3BIPA 2BHDA 3PKEA 2GG5A 4IKRA 2B3KA 2GU4A 5JI6A
chains in the Genus database with same CATH superfamily
2NQ6A 4EGEA 3PKAA 2BHCA 2V3ZA 2V3YA 2BWWA 1QXYA 1C22A 1XGSA 4A6WA 2HOWA 1KQ0A 1N51A 2EA2A 4RZYA 4A6VA 2GU6A 1B6AA 4U6ZA 4U71A 2GG3A 2G6PA 2GTXA 4FO8A 2BHBA 5CDEA 1C21A 1Y1NA 2ADUA 2BWUA 2Q96A 1XGOA 4FLJA 4ZWOA 3L24A 1MATA 4FKCA 2Q8KA 3CTZA 1YW7A 3TAVA 3FM3A 2GZ5A 4B28A 3IU9A 4Z7MA 1R58A 2BWSA 1W2MA 2GGCA 1QXWA 4IKTA 4U6CA 2BWTA 4RZZA 4ZNGA 2GG2A 1BN5A 2EVOA 5CLSA 2EA4A 1PV9A 2NQ7A 1WL9A 5D6EA 1WN1A 5JFRA 4FO7A 2GA2A 1R5HA 2GG8A 4HXXA 1C23A 2EVCA 3PKCA 1XGNA 1JAWA 2GG9A 4U76A 3IU7A 1C24A 3S6BA 4RGZ1 5FCFA 3MR1A 2IW2A 2GGBA 2BHAA 2OKNA 3MX6A 4OOKA 4U69A 4ZWPA 3BIQA 1YJ3A 1M35A 2GG0A 1WL6A 4U6JA 2BH3A 2EVMA 3FMQA 2GU5A 4S2TP 3TB5A 1YW8A 4U6EA 4IECA 4PV4A 2BWXA 2BB7A 1B59A 4JUQA 1WLRA 1W7VA 4U73A 3IU8A 4R60A 5E5BA 3CB6A 2B3LA 4IDYA 4U70A 1XNZA 2Q93A 1CHMA 2P98A 4IU6A 4IPAA 1A16A 2ZSGA 3IG4A 4S01A 3FMRA 4U75A 1KQ9A 1XGMA 2V6CA 1KP0A 2BWYA 2B3HA 4KM3A 1QZYA 5CDVA 2DFIA 3MATA 4IKUA 4MATA 1QXZA 1O0XA 1WBQA 3PKBA 4S2RP 1BOAA 4QR8A 3CB5A 2OAZA 3D27A 4FUKA 4FLLA 3RORA 5CNXA 2P9AA 1YW9A 3RVAA 5CE6A 1YVMA 2BN7A 1R5GA 1WY2A 2GU7A 1WKMA 5CIKA 3PKDA 2Q95A 4ZWUA 2BWVA 2MATA 2GG7A 4U1BA 4U6WA 4S00A 2P99A 5CDLA 3BITA 1C27A 2V3XA 4IF7A 5D6FA 2Q94A 3Q6DA 5FCHA 3L7GA 4FLIA 4PNCA 4FLKA 4IKSA 5JHUA 2Q92A 3BIPA 2BHDA 3PKEA 2GG5A 4IKRA 2B3KA 2GU4A 5JI6A
chains in the Genus database with same CATH topology
2NQ6A 4EGEA 3PKAA 2BHCA 2V3ZA 2V3YA 2BWWA 1QXYA 1C22A 1XGSA 4A6WA 2HOWA 1KQ0A 1N51A 2EA2A 4RZYA 4A6VA 2GU6A 1B6AA 4U6ZA 4U71A 2GG3A 2G6PA 2GTXA 4FO8A 2BHBA 5CDEA 1C21A 1Y1NA 2ADUA 2BWUA 2Q96A 1XGOA 4FLJA 4ZWOA 3L24A 1MATA 4FKCA 2Q8KA 3CTZA 1YW7A 3TAVA 3FM3A 2GZ5A 4B28A 3IU9A 4Z7MA 1R58A 2BWSA 1W2MA 2GGCA 1QXWA 4IKTA 4U6CA 2BWTA 4RZZA 4ZNGA 2GG2A 1BN5A 2EVOA 5CLSA 2EA4A 1PV9A 2NQ7A 1WL9A 5D6EA 1WN1A 5JFRA 4FO7A 2GA2A 1R5HA 2GG8A 4HXXA 1C23A 2EVCA 3PKCA 1XGNA 1JAWA 2GG9A 4U76A 3IU7A 1C24A 3S6BA 4RGZ1 5FCFA 3MR1A 2IW2A 2GGBA 2BHAA 2OKNA 3MX6A 4OOKA 4U69A 4ZWPA 3BIQA 1YJ3A 1M35A 2GG0A 1WL6A 4U6JA 2BH3A 2EVMA 3FMQA 2GU5A 4S2TP 3TB5A 1YW8A 4U6EA 4IECA 4PV4A 2BWXA 2BB7A 1B59A 4JUQA 1WLRA 1W7VA 4U73A 3IU8A 4R60A 5E5BA 3CB6A 2B3LA 4IDYA 4U70A 1XNZA 2Q93A 1CHMA 2P98A 4IU6A 4IPAA 1A16A 2ZSGA 3IG4A 4S01A 3FMRA 4U75A 1KQ9A 1XGMA 2V6CA 1KP0A 2BWYA 2B3HA 4KM3A 1QZYA 5CDVA 2DFIA 3MATA 4IKUA 4MATA 1QXZA 1O0XA 1WBQA 3PKBA 4S2RP 1BOAA 4QR8A 3CB5A 2OAZA 3D27A 4FUKA 4FLLA 3RORA 5CNXA 2P9AA 1YW9A 3RVAA 5CE6A 1YVMA 2BN7A 1R5GA 1WY2A 2GU7A 1WKMA 5CIKA 3PKDA 2Q95A 4ZWUA 2BWVA 2MATA 2GG7A 4U1BA 4U6WA 4S00A 2P99A 5CDLA 3BITA 1C27A 2V3XA 4IF7A 5D6FA 2Q94A 3Q6DA 5FCHA 3L7GA 4FLIA 4PNCA 4FLKA 4IKSA 5JHUA 2Q92A 3BIPA 2BHDA 3PKEA 2GG5A 4IKRA 2B3KA 2GU4A 5JI6A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2NQ6 A;  4EGE A;  3PKA A;  2BHC A;  2V3Z A;  2V3Y A;  2BWW A;  1QXY A;  1C22 A;  1XGS A;  4A6W A;  2HOW A;  1KQ0 A;  1N51 A;  2EA2 A;  4RZY A;  4A6V A;  2GU6 A;  1B6A A;  4U6Z A;  4U71 A;  2GG3 A;  2G6P A;  2GTX A;  4FO8 A;  2BHB A;  5CDE A;  1C21 A;  1Y1N A;  2ADU A;  2BWU A;  2Q96 A;  1XGO A;  4FLJ A;  4ZWO A;  3L24 A;  1MAT A;  4FKC A;  2Q8K A;  3CTZ A;  1YW7 A;  3TAV A;  3FM3 A;  2GZ5 A;  4B28 A;  3IU9 A;  4Z7M A;  1R58 A;  2BWS A;  1W2M A;  2GGC A;  1QXW A;  4IKT A;  4U6C A;  2BWT A;  4RZZ A;  4ZNG A;  2GG2 A;  1BN5 A;  2EVO A;  5CLS A;  2EA4 A;  1PV9 A;  2NQ7 A;  1WL9 A;  5D6E A;  1WN1 A;  5JFR A;  4FO7 A;  2GA2 A;  1R5H A;  2GG8 A;  4HXX A;  1C23 A;  2EVC A;  3PKC A;  1XGN A;  1JAW A;  2GG9 A;  4U76 A;  3IU7 A;  1C24 A;  3S6B A;  4RGZ 1;  5FCF A;  3MR1 A;  2IW2 A;  2GGB A;  2BHA A;  2OKN A;  3MX6 A;  4OOK A;  4U69 A;  4ZWP A;  3BIQ A;  1YJ3 A;  1M35 A;  2GG0 A;  1WL6 A;  4U6J A;  2BH3 A;  2EVM A;  3FMQ A;  2GU5 A;  4S2T P;  3TB5 A;  1YW8 A;  4U6E A;  4IEC A;  4PV4 A;  2BWX A;  2BB7 A;  1B59 A;  4JUQ A;  1WLR A;  1W7V A;  4U73 A;  3IU8 A;  4R60 A;  5E5B A;  3CB6 A;  2B3L A;  4IDY A;  4U70 A;  1XNZ A;  2Q93 A;  1CHM A;  2P98 A;  4IU6 A;  4IPA A;  1A16 A;  2ZSG A;  3IG4 A;  4S01 A;  3FMR A;  4U75 A;  1KQ9 A;  1XGM A;  2V6C A;  1KP0 A;  2BWY A;  2B3H A;  4KM3 A;  1QZY A;  5CDV A;  2DFI A;  3MAT A;  4IKU A;  4MAT A;  1QXZ A;  1O0X A;  1WBQ A;  3PKB A;  4S2R P;  1BOA A;  4QR8 A;  3CB5 A;  2OAZ A;  3D27 A;  4FUK A;  4FLL A;  3ROR A;  5CNX A;  2P9A A;  1YW9 A;  3RVA A;  5CE6 A;  1YVM A;  2BN7 A;  1R5G A;  1WY2 A;  2GU7 A;  1WKM A;  5CIK A;  3PKD A;  2Q95 A;  4ZWU A;  2BWV A;  2MAT A;  2GG7 A;  4U1B A;  4U6W A;  4S00 A;  2P99 A;  5CDL A;  3BIT A;  1C27 A;  2V3X A;  4IF7 A;  5D6F A;  2Q94 A;  3Q6D A;  5FCH A;  3L7G A;  4FLI A;  4PNC A;  4FLK A;  4IKS A;  5JHU A;  2Q92 A;  3BIP A;  2BHD A;  3PKE A;  2GG5 A;  4IKR A;  2B3K A;  2GU4 A;  5JI6 A; 
#chains in the Genus database with same CATH topology
 2NQ6 A;  4EGE A;  3PKA A;  2BHC A;  2V3Z A;  2V3Y A;  2BWW A;  1QXY A;  1C22 A;  1XGS A;  4A6W A;  2HOW A;  1KQ0 A;  1N51 A;  2EA2 A;  4RZY A;  4A6V A;  2GU6 A;  1B6A A;  4U6Z A;  4U71 A;  2GG3 A;  2G6P A;  2GTX A;  4FO8 A;  2BHB A;  5CDE A;  1C21 A;  1Y1N A;  2ADU A;  2BWU A;  2Q96 A;  1XGO A;  4FLJ A;  4ZWO A;  3L24 A;  1MAT A;  4FKC A;  2Q8K A;  3CTZ A;  1YW7 A;  3TAV A;  3FM3 A;  2GZ5 A;  4B28 A;  3IU9 A;  4Z7M A;  1R58 A;  2BWS A;  1W2M A;  2GGC A;  1QXW A;  4IKT A;  4U6C A;  2BWT A;  4RZZ A;  4ZNG A;  2GG2 A;  1BN5 A;  2EVO A;  5CLS A;  2EA4 A;  1PV9 A;  2NQ7 A;  1WL9 A;  5D6E A;  1WN1 A;  5JFR A;  4FO7 A;  2GA2 A;  1R5H A;  2GG8 A;  4HXX A;  1C23 A;  2EVC A;  3PKC A;  1XGN A;  1JAW A;  2GG9 A;  4U76 A;  3IU7 A;  1C24 A;  3S6B A;  4RGZ 1;  5FCF A;  3MR1 A;  2IW2 A;  2GGB A;  2BHA A;  2OKN A;  3MX6 A;  4OOK A;  4U69 A;  4ZWP A;  3BIQ A;  1YJ3 A;  1M35 A;  2GG0 A;  1WL6 A;  4U6J A;  2BH3 A;  2EVM A;  3FMQ A;  2GU5 A;  4S2T P;  3TB5 A;  1YW8 A;  4U6E A;  4IEC A;  4PV4 A;  2BWX A;  2BB7 A;  1B59 A;  4JUQ A;  1WLR A;  1W7V A;  4U73 A;  3IU8 A;  4R60 A;  5E5B A;  3CB6 A;  2B3L A;  4IDY A;  4U70 A;  1XNZ A;  2Q93 A;  1CHM A;  2P98 A;  4IU6 A;  4IPA A;  1A16 A;  2ZSG A;  3IG4 A;  4S01 A;  3FMR A;  4U75 A;  1KQ9 A;  1XGM A;  2V6C A;  1KP0 A;  2BWY A;  2B3H A;  4KM3 A;  1QZY A;  5CDV A;  2DFI A;  3MAT A;  4IKU A;  4MAT A;  1QXZ A;  1O0X A;  1WBQ A;  3PKB A;  4S2R P;  1BOA A;  4QR8 A;  3CB5 A;  2OAZ A;  3D27 A;  4FUK A;  4FLL A;  3ROR A;  5CNX A;  2P9A A;  1YW9 A;  3RVA A;  5CE6 A;  1YVM A;  2BN7 A;  1R5G A;  1WY2 A;  2GU7 A;  1WKM A;  5CIK A;  3PKD A;  2Q95 A;  4ZWU A;  2BWV A;  2MAT A;  2GG7 A;  4U1B A;  4U6W A;  4S00 A;  2P99 A;  5CDL A;  3BIT A;  1C27 A;  2V3X A;  4IF7 A;  5D6F A;  2Q94 A;  3Q6D A;  5FCH A;  3L7G A;  4FLI A;  4PNC A;  4FLK A;  4IKS A;  5JHU A;  2Q92 A;  3BIP A;  2BHD A;  3PKE A;  2GG5 A;  4IKR A;  2B3K A;  2GU4 A;  5JI6 A; 
#chains in the Genus database with same CATH homology
 2NQ6 A;  4EGE A;  3PKA A;  2BHC A;  2V3Z A;  2V3Y A;  2BWW A;  1QXY A;  1C22 A;  1XGS A;  4A6W A;  2HOW A;  1KQ0 A;  1N51 A;  2EA2 A;  4RZY A;  4A6V A;  2GU6 A;  1B6A A;  4U6Z A;  4U71 A;  2GG3 A;  2G6P A;  2GTX A;  4FO8 A;  2BHB A;  5CDE A;  1C21 A;  1Y1N A;  2ADU A;  2BWU A;  2Q96 A;  1XGO A;  4FLJ A;  4ZWO A;  3L24 A;  1MAT A;  4FKC A;  2Q8K A;  3CTZ A;  1YW7 A;  3TAV A;  3FM3 A;  2GZ5 A;  4B28 A;  3IU9 A;  4Z7M A;  1R58 A;  2BWS A;  1W2M A;  2GGC A;  1QXW A;  4IKT A;  4U6C A;  2BWT A;  4RZZ A;  4ZNG A;  2GG2 A;  1BN5 A;  2EVO A;  5CLS A;  2EA4 A;  1PV9 A;  2NQ7 A;  1WL9 A;  5D6E A;  1WN1 A;  5JFR A;  4FO7 A;  2GA2 A;  1R5H A;  2GG8 A;  4HXX A;  1C23 A;  2EVC A;  3PKC A;  1XGN A;  1JAW A;  2GG9 A;  4U76 A;  3IU7 A;  1C24 A;  3S6B A;  4RGZ 1;  5FCF A;  3MR1 A;  2IW2 A;  2GGB A;  2BHA A;  2OKN A;  3MX6 A;  4OOK A;  4U69 A;  4ZWP A;  3BIQ A;  1YJ3 A;  1M35 A;  2GG0 A;  1WL6 A;  4U6J A;  2BH3 A;  2EVM A;  3FMQ A;  2GU5 A;  4S2T P;  3TB5 A;  1YW8 A;  4U6E A;  4IEC A;  4PV4 A;  2BWX A;  2BB7 A;  1B59 A;  4JUQ A;  1WLR A;  1W7V A;  4U73 A;  3IU8 A;  4R60 A;  5E5B A;  3CB6 A;  2B3L A;  4IDY A;  4U70 A;  1XNZ A;  2Q93 A;  1CHM A;  2P98 A;  4IU6 A;  4IPA A;  1A16 A;  2ZSG A;  3IG4 A;  4S01 A;  3FMR A;  4U75 A;  1KQ9 A;  1XGM A;  2V6C A;  1KP0 A;  2BWY A;  2B3H A;  4KM3 A;  1QZY A;  5CDV A;  2DFI A;  3MAT A;  4IKU A;  4MAT A;  1QXZ A;  1O0X A;  1WBQ A;  3PKB A;  4S2R P;  1BOA A;  4QR8 A;  3CB5 A;  2OAZ A;  3D27 A;  4FUK A;  4FLL A;  3ROR A;  5CNX A;  2P9A A;  1YW9 A;  3RVA A;  5CE6 A;  1YVM A;  2BN7 A;  1R5G A;  1WY2 A;  2GU7 A;  1WKM A;  5CIK A;  3PKD A;  2Q95 A;  4ZWU A;  2BWV A;  2MAT A;  2GG7 A;  4U1B A;  4U6W A;  4S00 A;  2P99 A;  5CDL A;  3BIT A;  1C27 A;  2V3X A;  4IF7 A;  5D6F A;  2Q94 A;  3Q6D A;  5FCH A;  3L7G A;  4FLI A;  4PNC A;  4FLK A;  4IKS A;  5JHU A;  2Q92 A;  3BIP A;  2BHD A;  3PKE A;  2GG5 A;  4IKR A;  2B3K A;  2GU4 A;  5JI6 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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