2BB7A

Mn form of e. coli methionine aminopeptidase in complex with a quinolinyl sulfonamide inhibitor
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
258
structure length
258
Chain Sequence
IKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Metal mediated inhibition of methionine aminopeptidase by quinolinyl sulfonamides
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 84
structure length 258
sequence length 258
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-17

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2bb7A00
4KM3A 4FLIA 2Q93A 3CB5A 2BWSA 3CB6A 1WKMA 2BN7A 1YVMA 2GU4A 2EVOA 3MR1A 3FMRA 1R58A 2BWXA 4JUQA 4PNCA 4FLKA 2BH3A 3IU8A 1KQ0A 4Z7MA 3D27A 1XGMA 4PV4A 4U73A 1M35A 3TB5A 3IG4A 4FLJA 2NQ6A 2BB7A 3MX6A 4IECA 4U69A 1YW7A 3FMQA 3S6BA 2BWVA 2EA4A 2V3YA 4U6JA 3L7GA 1A16A 1BOAA 2DFIA 2GG0A 1WL9A 4U76A 3RVAA 2P99A 3CTZA 3FM3A 3BIPA 5JFRA 1KQ9A 3PKDA 4IPAA 3PKEA 1WL6A 1WLRA 4OOKA 4U70A 5CNXA 2GZ5A 1R5HA 3BIQA 2EA2A 1W7VA 1WY2A 2Q96A 1CHMA 2V3XA 2ZSGA 3L24A 4U75A 1C24A 4IF7A 2ADUA 4FO7A 3IU9A 4R60A 4B28A 5D6FA 4ZWPA 2Q8KA 2Q95A 1WBQA 1WN1A 2OAZA 4ZWUA 4IKRA 1YW9A 2HOWA 2BHCA 1C21A 4FKCA 1XNZA 2OKNA 1JAWA 1XGOA 1Y1NA 4IKUA 2GA2A 1QZYA 3Q6DA 4HXXA 2BHAA 4ZNGA 1B6AA 1QXWA 1C22A 2BWUA 4FUKA 4S00A 1N51A 1O0XA 2GG3A 1R5GA 3PKBA 2IW2A 5CDVA 2B3LA 5CDLA 2B3KA 1YW8A 4A6WA 4U71A 1YJ3A 5D6EA 2GG7A 3PKAA 4IDYA 4RZZA 5FCFA 4S01A 4U6CA 3MATA 1XGSA 2P98A 4S2RP 2GU6A 3TAVA 2GG8A 3BITA 5CLSA 1W2MA 2GU5A 4IU6A 4RGZ1 2B3HA 2GG9A 2EVCA 1B59A 1C27A 1MATA 1QXZA 2G6PA 2V3ZA 2GGCA 5CDEA 4MATA 2NQ7A 4A6VA 4IKSA 4U6ZA 2EVMA 3RORA 2BHBA 5E5BA 5CIKA 4IKTA 4RZYA 2GG5A 4U6WA 4EGEA 4ZWOA 1KP0A 1QXYA 2BHDA 1XGNA 1BN5A 3IU7A 2MATA 2Q94A 4FLLA 5JHUA 5JI6A 4U1BA 1C23A 5CE6A 3PKCA 5FCHA 4S2TP 2Q92A 2GTXA 2P9AA 1PV9A 2V6CA 4FO8A 2BWYA 4QR8A 2BWTA 2BWWA 2GGBA 4U6EA 2GU7A 2GG2A
chains in the Genus database with same CATH superfamily
4KM3A 4FLIA 2Q93A 3CB5A 2BWSA 3CB6A 1WKMA 2BN7A 1YVMA 2GU4A 2EVOA 3MR1A 3FMRA 1R58A 2BWXA 4JUQA 4PNCA 4FLKA 2BH3A 3IU8A 1KQ0A 4Z7MA 3D27A 1XGMA 4PV4A 4U73A 1M35A 3TB5A 3IG4A 4FLJA 2NQ6A 2BB7A 3MX6A 4IECA 4U69A 1YW7A 3FMQA 3S6BA 2BWVA 2EA4A 2V3YA 4U6JA 3L7GA 1A16A 1BOAA 2DFIA 2GG0A 1WL9A 4U76A 3RVAA 2P99A 3CTZA 3FM3A 3BIPA 5JFRA 1KQ9A 3PKDA 4IPAA 3PKEA 1WL6A 1WLRA 4OOKA 4U70A 5CNXA 2GZ5A 1R5HA 3BIQA 2EA2A 1W7VA 1WY2A 2Q96A 1CHMA 2V3XA 2ZSGA 3L24A 4U75A 1C24A 4IF7A 2ADUA 4FO7A 3IU9A 4R60A 4B28A 5D6FA 4ZWPA 2Q8KA 2Q95A 1WBQA 1WN1A 2OAZA 4ZWUA 4IKRA 1YW9A 2HOWA 2BHCA 1C21A 4FKCA 1XNZA 2OKNA 1JAWA 1XGOA 1Y1NA 4IKUA 2GA2A 1QZYA 3Q6DA 4HXXA 2BHAA 4ZNGA 1B6AA 1QXWA 1C22A 2BWUA 4FUKA 4S00A 1N51A 1O0XA 2GG3A 1R5GA 3PKBA 2IW2A 5CDVA 2B3LA 5CDLA 2B3KA 1YW8A 4A6WA 4U71A 1YJ3A 5D6EA 2GG7A 3PKAA 4IDYA 4RZZA 5FCFA 4S01A 4U6CA 3MATA 1XGSA 2P98A 4S2RP 2GU6A 3TAVA 2GG8A 3BITA 5CLSA 1W2MA 2GU5A 4IU6A 4RGZ1 2B3HA 2GG9A 2EVCA 1B59A 1C27A 1MATA 1QXZA 2G6PA 2V3ZA 2GGCA 5CDEA 4MATA 2NQ7A 4A6VA 4IKSA 4U6ZA 2EVMA 3RORA 2BHBA 5E5BA 5CIKA 4IKTA 4RZYA 2GG5A 4U6WA 4EGEA 4ZWOA 1KP0A 1QXYA 2BHDA 1XGNA 1BN5A 3IU7A 2MATA 2Q94A 4FLLA 5JHUA 5JI6A 4U1BA 1C23A 5CE6A 3PKCA 5FCHA 4S2TP 2Q92A 2GTXA 2P9AA 1PV9A 2V6CA 4FO8A 2BWYA 4QR8A 2BWTA 2BWWA 2GGBA 4U6EA 2GU7A 2GG2A
chains in the Genus database with same CATH topology
4KM3A 4FLIA 2Q93A 3CB5A 2BWSA 3CB6A 1WKMA 2BN7A 1YVMA 2GU4A 2EVOA 3MR1A 3FMRA 1R58A 2BWXA 4JUQA 4PNCA 4FLKA 2BH3A 3IU8A 1KQ0A 4Z7MA 3D27A 1XGMA 4PV4A 4U73A 1M35A 3TB5A 3IG4A 4FLJA 2NQ6A 2BB7A 3MX6A 4IECA 4U69A 1YW7A 3FMQA 3S6BA 2BWVA 2EA4A 2V3YA 4U6JA 3L7GA 1A16A 1BOAA 2DFIA 2GG0A 1WL9A 4U76A 3RVAA 2P99A 3CTZA 3FM3A 3BIPA 5JFRA 1KQ9A 3PKDA 4IPAA 3PKEA 1WL6A 1WLRA 4OOKA 4U70A 5CNXA 2GZ5A 1R5HA 3BIQA 2EA2A 1W7VA 1WY2A 2Q96A 1CHMA 2V3XA 2ZSGA 3L24A 4U75A 1C24A 4IF7A 2ADUA 4FO7A 3IU9A 4R60A 4B28A 5D6FA 4ZWPA 2Q8KA 2Q95A 1WBQA 1WN1A 2OAZA 4ZWUA 4IKRA 1YW9A 2HOWA 2BHCA 1C21A 4FKCA 1XNZA 2OKNA 1JAWA 1XGOA 1Y1NA 4IKUA 2GA2A 1QZYA 3Q6DA 4HXXA 2BHAA 4ZNGA 1B6AA 1QXWA 1C22A 2BWUA 4FUKA 4S00A 1N51A 1O0XA 2GG3A 1R5GA 3PKBA 2IW2A 5CDVA 2B3LA 5CDLA 2B3KA 1YW8A 4A6WA 4U71A 1YJ3A 5D6EA 2GG7A 3PKAA 4IDYA 4RZZA 5FCFA 4S01A 4U6CA 3MATA 1XGSA 2P98A 4S2RP 2GU6A 3TAVA 2GG8A 3BITA 5CLSA 1W2MA 2GU5A 4IU6A 4RGZ1 2B3HA 2GG9A 2EVCA 1B59A 1C27A 1MATA 1QXZA 2G6PA 2V3ZA 2GGCA 5CDEA 4MATA 2NQ7A 4A6VA 4IKSA 4U6ZA 2EVMA 3RORA 2BHBA 5E5BA 5CIKA 4IKTA 4RZYA 2GG5A 4U6WA 4EGEA 4ZWOA 1KP0A 1QXYA 2BHDA 1XGNA 1BN5A 3IU7A 2MATA 2Q94A 4FLLA 5JHUA 5JI6A 4U1BA 1C23A 5CE6A 3PKCA 5FCHA 4S2TP 2Q92A 2GTXA 2P9AA 1PV9A 2V6CA 4FO8A 2BWYA 4QR8A 2BWTA 2BWWA 2GGBA 4U6EA 2GU7A 2GG2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KM3 A;  4FLI A;  2Q93 A;  3CB5 A;  2BWS A;  3CB6 A;  1WKM A;  2BN7 A;  1YVM A;  2GU4 A;  2EVO A;  3MR1 A;  3FMR A;  1R58 A;  2BWX A;  4JUQ A;  4PNC A;  4FLK A;  2BH3 A;  3IU8 A;  1KQ0 A;  4Z7M A;  3D27 A;  1XGM A;  4PV4 A;  4U73 A;  1M35 A;  3TB5 A;  3IG4 A;  4FLJ A;  2NQ6 A;  2BB7 A;  3MX6 A;  4IEC A;  4U69 A;  1YW7 A;  3FMQ A;  3S6B A;  2BWV A;  2EA4 A;  2V3Y A;  4U6J A;  3L7G A;  1A16 A;  1BOA A;  2DFI A;  2GG0 A;  1WL9 A;  4U76 A;  3RVA A;  2P99 A;  3CTZ A;  3FM3 A;  3BIP A;  5JFR A;  1KQ9 A;  3PKD A;  4IPA A;  3PKE A;  1WL6 A;  1WLR A;  4OOK A;  4U70 A;  5CNX A;  2GZ5 A;  1R5H A;  3BIQ A;  2EA2 A;  1W7V A;  1WY2 A;  2Q96 A;  1CHM A;  2V3X A;  2ZSG A;  3L24 A;  4U75 A;  1C24 A;  4IF7 A;  2ADU A;  4FO7 A;  3IU9 A;  4R60 A;  4B28 A;  5D6F A;  4ZWP A;  2Q8K A;  2Q95 A;  1WBQ A;  1WN1 A;  2OAZ A;  4ZWU A;  4IKR A;  1YW9 A;  2HOW A;  2BHC A;  1C21 A;  4FKC A;  1XNZ A;  2OKN A;  1JAW A;  1XGO A;  1Y1N A;  4IKU A;  2GA2 A;  1QZY A;  3Q6D A;  4HXX A;  2BHA A;  4ZNG A;  1B6A A;  1QXW A;  1C22 A;  2BWU A;  4FUK A;  4S00 A;  1N51 A;  1O0X A;  2GG3 A;  1R5G A;  3PKB A;  2IW2 A;  5CDV A;  2B3L A;  5CDL A;  2B3K A;  1YW8 A;  4A6W A;  4U71 A;  1YJ3 A;  5D6E A;  2GG7 A;  3PKA A;  4IDY A;  4RZZ A;  5FCF A;  4S01 A;  4U6C A;  3MAT A;  1XGS A;  2P98 A;  4S2R P;  2GU6 A;  3TAV A;  2GG8 A;  3BIT A;  5CLS A;  1W2M A;  2GU5 A;  4IU6 A;  4RGZ 1;  2B3H A;  2GG9 A;  2EVC A;  1B59 A;  1C27 A;  1MAT A;  1QXZ A;  2G6P A;  2V3Z A;  2GGC A;  5CDE A;  4MAT A;  2NQ7 A;  4A6V A;  4IKS A;  4U6Z A;  2EVM A;  3ROR A;  2BHB A;  5E5B A;  5CIK A;  4IKT A;  4RZY A;  2GG5 A;  4U6W A;  4EGE A;  4ZWO A;  1KP0 A;  1QXY A;  2BHD A;  1XGN A;  1BN5 A;  3IU7 A;  2MAT A;  2Q94 A;  4FLL A;  5JHU A;  5JI6 A;  4U1B A;  1C23 A;  5CE6 A;  3PKC A;  5FCH A;  4S2T P;  2Q92 A;  2GTX A;  2P9A A;  1PV9 A;  2V6C A;  4FO8 A;  2BWY A;  4QR8 A;  2BWT A;  2BWW A;  2GGB A;  4U6E A;  2GU7 A;  2GG2 A; 
#chains in the Genus database with same CATH topology
 4KM3 A;  4FLI A;  2Q93 A;  3CB5 A;  2BWS A;  3CB6 A;  1WKM A;  2BN7 A;  1YVM A;  2GU4 A;  2EVO A;  3MR1 A;  3FMR A;  1R58 A;  2BWX A;  4JUQ A;  4PNC A;  4FLK A;  2BH3 A;  3IU8 A;  1KQ0 A;  4Z7M A;  3D27 A;  1XGM A;  4PV4 A;  4U73 A;  1M35 A;  3TB5 A;  3IG4 A;  4FLJ A;  2NQ6 A;  2BB7 A;  3MX6 A;  4IEC A;  4U69 A;  1YW7 A;  3FMQ A;  3S6B A;  2BWV A;  2EA4 A;  2V3Y A;  4U6J A;  3L7G A;  1A16 A;  1BOA A;  2DFI A;  2GG0 A;  1WL9 A;  4U76 A;  3RVA A;  2P99 A;  3CTZ A;  3FM3 A;  3BIP A;  5JFR A;  1KQ9 A;  3PKD A;  4IPA A;  3PKE A;  1WL6 A;  1WLR A;  4OOK A;  4U70 A;  5CNX A;  2GZ5 A;  1R5H A;  3BIQ A;  2EA2 A;  1W7V A;  1WY2 A;  2Q96 A;  1CHM A;  2V3X A;  2ZSG A;  3L24 A;  4U75 A;  1C24 A;  4IF7 A;  2ADU A;  4FO7 A;  3IU9 A;  4R60 A;  4B28 A;  5D6F A;  4ZWP A;  2Q8K A;  2Q95 A;  1WBQ A;  1WN1 A;  2OAZ A;  4ZWU A;  4IKR A;  1YW9 A;  2HOW A;  2BHC A;  1C21 A;  4FKC A;  1XNZ A;  2OKN A;  1JAW A;  1XGO A;  1Y1N A;  4IKU A;  2GA2 A;  1QZY A;  3Q6D A;  4HXX A;  2BHA A;  4ZNG A;  1B6A A;  1QXW A;  1C22 A;  2BWU A;  4FUK A;  4S00 A;  1N51 A;  1O0X A;  2GG3 A;  1R5G A;  3PKB A;  2IW2 A;  5CDV A;  2B3L A;  5CDL A;  2B3K A;  1YW8 A;  4A6W A;  4U71 A;  1YJ3 A;  5D6E A;  2GG7 A;  3PKA A;  4IDY A;  4RZZ A;  5FCF A;  4S01 A;  4U6C A;  3MAT A;  1XGS A;  2P98 A;  4S2R P;  2GU6 A;  3TAV A;  2GG8 A;  3BIT A;  5CLS A;  1W2M A;  2GU5 A;  4IU6 A;  4RGZ 1;  2B3H A;  2GG9 A;  2EVC A;  1B59 A;  1C27 A;  1MAT A;  1QXZ A;  2G6P A;  2V3Z A;  2GGC A;  5CDE A;  4MAT A;  2NQ7 A;  4A6V A;  4IKS A;  4U6Z A;  2EVM A;  3ROR A;  2BHB A;  5E5B A;  5CIK A;  4IKT A;  4RZY A;  2GG5 A;  4U6W A;  4EGE A;  4ZWO A;  1KP0 A;  1QXY A;  2BHD A;  1XGN A;  1BN5 A;  3IU7 A;  2MAT A;  2Q94 A;  4FLL A;  5JHU A;  5JI6 A;  4U1B A;  1C23 A;  5CE6 A;  3PKC A;  5FCH A;  4S2T P;  2Q92 A;  2GTX A;  2P9A A;  1PV9 A;  2V6C A;  4FO8 A;  2BWY A;  4QR8 A;  2BWT A;  2BWW A;  2GGB A;  4U6E A;  2GU7 A;  2GG2 A; 
#chains in the Genus database with same CATH homology
 4KM3 A;  4FLI A;  2Q93 A;  3CB5 A;  2BWS A;  3CB6 A;  1WKM A;  2BN7 A;  1YVM A;  2GU4 A;  2EVO A;  3MR1 A;  3FMR A;  1R58 A;  2BWX A;  4JUQ A;  4PNC A;  4FLK A;  2BH3 A;  3IU8 A;  1KQ0 A;  4Z7M A;  3D27 A;  1XGM A;  4PV4 A;  4U73 A;  1M35 A;  3TB5 A;  3IG4 A;  4FLJ A;  2NQ6 A;  2BB7 A;  3MX6 A;  4IEC A;  4U69 A;  1YW7 A;  3FMQ A;  3S6B A;  2BWV A;  2EA4 A;  2V3Y A;  4U6J A;  3L7G A;  1A16 A;  1BOA A;  2DFI A;  2GG0 A;  1WL9 A;  4U76 A;  3RVA A;  2P99 A;  3CTZ A;  3FM3 A;  3BIP A;  5JFR A;  1KQ9 A;  3PKD A;  4IPA A;  3PKE A;  1WL6 A;  1WLR A;  4OOK A;  4U70 A;  5CNX A;  2GZ5 A;  1R5H A;  3BIQ A;  2EA2 A;  1W7V A;  1WY2 A;  2Q96 A;  1CHM A;  2V3X A;  2ZSG A;  3L24 A;  4U75 A;  1C24 A;  4IF7 A;  2ADU A;  4FO7 A;  3IU9 A;  4R60 A;  4B28 A;  5D6F A;  4ZWP A;  2Q8K A;  2Q95 A;  1WBQ A;  1WN1 A;  2OAZ A;  4ZWU A;  4IKR A;  1YW9 A;  2HOW A;  2BHC A;  1C21 A;  4FKC A;  1XNZ A;  2OKN A;  1JAW A;  1XGO A;  1Y1N A;  4IKU A;  2GA2 A;  1QZY A;  3Q6D A;  4HXX A;  2BHA A;  4ZNG A;  1B6A A;  1QXW A;  1C22 A;  2BWU A;  4FUK A;  4S00 A;  1N51 A;  1O0X A;  2GG3 A;  1R5G A;  3PKB A;  2IW2 A;  5CDV A;  2B3L A;  5CDL A;  2B3K A;  1YW8 A;  4A6W A;  4U71 A;  1YJ3 A;  5D6E A;  2GG7 A;  3PKA A;  4IDY A;  4RZZ A;  5FCF A;  4S01 A;  4U6C A;  3MAT A;  1XGS A;  2P98 A;  4S2R P;  2GU6 A;  3TAV A;  2GG8 A;  3BIT A;  5CLS A;  1W2M A;  2GU5 A;  4IU6 A;  4RGZ 1;  2B3H A;  2GG9 A;  2EVC A;  1B59 A;  1C27 A;  1MAT A;  1QXZ A;  2G6P A;  2V3Z A;  2GGC A;  5CDE A;  4MAT A;  2NQ7 A;  4A6V A;  4IKS A;  4U6Z A;  2EVM A;  3ROR A;  2BHB A;  5E5B A;  5CIK A;  4IKT A;  4RZY A;  2GG5 A;  4U6W A;  4EGE A;  4ZWO A;  1KP0 A;  1QXY A;  2BHD A;  1XGN A;  1BN5 A;  3IU7 A;  2MAT A;  2Q94 A;  4FLL A;  5JHU A;  5JI6 A;  4U1B A;  1C23 A;  5CE6 A;  3PKC A;  5FCH A;  4S2T P;  2Q92 A;  2GTX A;  2P9A A;  1PV9 A;  2V6C A;  4FO8 A;  2BWY A;  4QR8 A;  2BWT A;  2BWW A;  2GGB A;  4U6E A;  2GU7 A;  2GG2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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