2EVCA

Crystal structure of e. coli. methionine amino peptidase in complex with 5-(2-(trifluoromethyl)phenyl)furan-2-carboxylic acid
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
259
structure length
259
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 85
structure length 259
sequence length 259
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evcA00
5FCFA 4IKSA 4EGEA 2GG8A 1B6AA 2IW2A 2BN7A 4ZWUA 4FLKA 5E5BA 4FLIA 4FLJA 2BWVA 4U76A 1MATA 3IU8A 5JHUA 4U71A 4IU6A 3TB5A 4IKRA 1QXWA 1WL6A 5JI6A 4RZYA 4FKCA 2GTXA 2BB7A 5CNXA 1XNZA 2GA2A 1XGNA 5CDEA 4U1BA 1JAWA 2OAZA 3MR1A 1C22A 2GG5A 4U75A 3MATA 4S2RP 4ZWOA 3CTZA 1C23A 1WN1A 2P99A 3Q6DA 2OKNA 4OOKA 4R60A 1A16A 3BIPA 2Q94A 4HXXA 1R58A 2GG9A 4Z7MA 2EA4A 2GG0A 5D6FA 2B3KA 2BWSA 4FLLA 2Q95A 3PKEA 4ZWPA 1QZYA 2BWXA 2V3XA 2Q93A 1XGOA 2GGBA 2G6PA 2BH3A 1KQ9A 2GU6A 4FO8A 4S2TP 3FMRA 4U6ZA 3L7GA 2GU5A 2BWTA 2ADUA 1XGMA 5CDLA 5CLSA 2DFIA 1YW9A 5CDVA 5FCHA 4U6JA 2BWYA 2EVMA 1YW8A 2BWUA 1YJ3A 2GG2A 4IDYA 1W2MA 1B59A 2B3HA 4JUQA 2GG3A 2EVCA 2BHAA 1R5HA 4U69A 2Q92A 1W7VA 2P9AA 4S00A 2BHCA 1CHMA 3PKCA 5CIKA 2GG7A 1BN5A 1BOAA 3IU9A 4PV4A 3D27A 2EA2A 1C24A 2GU7A 4U73A 1M35A 3RORA 1YVMA 5JFRA 1QXYA 4B28A 4U70A 4IECA 4IPAA 2MATA 3PKAA 1Y1NA 1PV9A 1WY2A 3PKBA 2V3ZA 4RZZA 4RGZ1 4A6WA 1N51A 1YW7A 3CB5A 1XGSA 4S01A 1WL9A 2V3YA 3RVAA 4IKTA 3FM3A 2NQ7A 1KP0A 2V6CA 2B3LA 1WLRA 3BIQA 2BHDA 2GGCA 2NQ6A 3S6BA 2Q8KA 2P98A 3BITA 4U6CA 4FUKA 4A6VA 3MX6A 2BHBA 1C27A 4KM3A 2ZSGA 4IF7A 4IKUA 4QR8A 1WKMA 4PNCA 3PKDA 1QXZA 2Q96A 3IU7A 2GU4A 3IG4A 2BWWA 3L24A 4FO7A 2HOWA 5D6EA 3TAVA 1KQ0A 4U6WA 4MATA 1O0XA 5CE6A 1WBQA 3CB6A 2EVOA 2GZ5A 4U6EA 4ZNGA 1C21A 3FMQA 1R5GA
chains in the Genus database with same CATH superfamily
5FCFA 4IKSA 4EGEA 2GG8A 1B6AA 2IW2A 2BN7A 4ZWUA 4FLKA 5E5BA 4FLIA 4FLJA 2BWVA 4U76A 1MATA 3IU8A 5JHUA 4U71A 4IU6A 3TB5A 4IKRA 1QXWA 1WL6A 5JI6A 4RZYA 4FKCA 2GTXA 2BB7A 5CNXA 1XNZA 2GA2A 1XGNA 5CDEA 4U1BA 1JAWA 2OAZA 3MR1A 1C22A 2GG5A 4U75A 3MATA 4S2RP 4ZWOA 3CTZA 1C23A 1WN1A 2P99A 3Q6DA 2OKNA 4OOKA 4R60A 1A16A 3BIPA 2Q94A 4HXXA 1R58A 2GG9A 4Z7MA 2EA4A 2GG0A 5D6FA 2B3KA 2BWSA 4FLLA 2Q95A 3PKEA 4ZWPA 1QZYA 2BWXA 2V3XA 2Q93A 1XGOA 2GGBA 2G6PA 2BH3A 1KQ9A 2GU6A 4FO8A 4S2TP 3FMRA 4U6ZA 3L7GA 2GU5A 2BWTA 2ADUA 1XGMA 5CDLA 5CLSA 2DFIA 1YW9A 5CDVA 5FCHA 4U6JA 2BWYA 2EVMA 1YW8A 2BWUA 1YJ3A 2GG2A 4IDYA 1W2MA 1B59A 2B3HA 4JUQA 2GG3A 2EVCA 2BHAA 1R5HA 4U69A 2Q92A 1W7VA 2P9AA 4S00A 2BHCA 1CHMA 3PKCA 5CIKA 2GG7A 1BN5A 1BOAA 3IU9A 4PV4A 3D27A 2EA2A 1C24A 2GU7A 4U73A 1M35A 3RORA 1YVMA 5JFRA 1QXYA 4B28A 4U70A 4IECA 4IPAA 2MATA 3PKAA 1Y1NA 1PV9A 1WY2A 3PKBA 2V3ZA 4RZZA 4RGZ1 4A6WA 1N51A 1YW7A 3CB5A 1XGSA 4S01A 1WL9A 2V3YA 3RVAA 4IKTA 3FM3A 2NQ7A 1KP0A 2V6CA 2B3LA 1WLRA 3BIQA 2BHDA 2GGCA 2NQ6A 3S6BA 2Q8KA 2P98A 3BITA 4U6CA 4FUKA 4A6VA 3MX6A 2BHBA 1C27A 4KM3A 2ZSGA 4IF7A 4IKUA 4QR8A 1WKMA 4PNCA 3PKDA 1QXZA 2Q96A 3IU7A 2GU4A 3IG4A 2BWWA 3L24A 4FO7A 2HOWA 5D6EA 3TAVA 1KQ0A 4U6WA 4MATA 1O0XA 5CE6A 1WBQA 3CB6A 2EVOA 2GZ5A 4U6EA 4ZNGA 1C21A 3FMQA 1R5GA
chains in the Genus database with same CATH topology
5FCFA 4IKSA 4EGEA 2GG8A 1B6AA 2IW2A 2BN7A 4ZWUA 4FLKA 5E5BA 4FLIA 4FLJA 2BWVA 4U76A 1MATA 3IU8A 5JHUA 4U71A 4IU6A 3TB5A 4IKRA 1QXWA 1WL6A 5JI6A 4RZYA 4FKCA 2GTXA 2BB7A 5CNXA 1XNZA 2GA2A 1XGNA 5CDEA 4U1BA 1JAWA 2OAZA 3MR1A 1C22A 2GG5A 4U75A 3MATA 4S2RP 4ZWOA 3CTZA 1C23A 1WN1A 2P99A 3Q6DA 2OKNA 4OOKA 4R60A 1A16A 3BIPA 2Q94A 4HXXA 1R58A 2GG9A 4Z7MA 2EA4A 2GG0A 5D6FA 2B3KA 2BWSA 4FLLA 2Q95A 3PKEA 4ZWPA 1QZYA 2BWXA 2V3XA 2Q93A 1XGOA 2GGBA 2G6PA 2BH3A 1KQ9A 2GU6A 4FO8A 4S2TP 3FMRA 4U6ZA 3L7GA 2GU5A 2BWTA 2ADUA 1XGMA 5CDLA 5CLSA 2DFIA 1YW9A 5CDVA 5FCHA 4U6JA 2BWYA 2EVMA 1YW8A 2BWUA 1YJ3A 2GG2A 4IDYA 1W2MA 1B59A 2B3HA 4JUQA 2GG3A 2EVCA 2BHAA 1R5HA 4U69A 2Q92A 1W7VA 2P9AA 4S00A 2BHCA 1CHMA 3PKCA 5CIKA 2GG7A 1BN5A 1BOAA 3IU9A 4PV4A 3D27A 2EA2A 1C24A 2GU7A 4U73A 1M35A 3RORA 1YVMA 5JFRA 1QXYA 4B28A 4U70A 4IECA 4IPAA 2MATA 3PKAA 1Y1NA 1PV9A 1WY2A 3PKBA 2V3ZA 4RZZA 4RGZ1 4A6WA 1N51A 1YW7A 3CB5A 1XGSA 4S01A 1WL9A 2V3YA 3RVAA 4IKTA 3FM3A 2NQ7A 1KP0A 2V6CA 2B3LA 1WLRA 3BIQA 2BHDA 2GGCA 2NQ6A 3S6BA 2Q8KA 2P98A 3BITA 4U6CA 4FUKA 4A6VA 3MX6A 2BHBA 1C27A 4KM3A 2ZSGA 4IF7A 4IKUA 4QR8A 1WKMA 4PNCA 3PKDA 1QXZA 2Q96A 3IU7A 2GU4A 3IG4A 2BWWA 3L24A 4FO7A 2HOWA 5D6EA 3TAVA 1KQ0A 4U6WA 4MATA 1O0XA 5CE6A 1WBQA 3CB6A 2EVOA 2GZ5A 4U6EA 4ZNGA 1C21A 3FMQA 1R5GA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5FCF A;  4IKS A;  4EGE A;  2GG8 A;  1B6A A;  2IW2 A;  2BN7 A;  4ZWU A;  4FLK A;  5E5B A;  4FLI A;  4FLJ A;  2BWV A;  4U76 A;  1MAT A;  3IU8 A;  5JHU A;  4U71 A;  4IU6 A;  3TB5 A;  4IKR A;  1QXW A;  1WL6 A;  5JI6 A;  4RZY A;  4FKC A;  2GTX A;  2BB7 A;  5CNX A;  1XNZ A;  2GA2 A;  1XGN A;  5CDE A;  4U1B A;  1JAW A;  2OAZ A;  3MR1 A;  1C22 A;  2GG5 A;  4U75 A;  3MAT A;  4S2R P;  4ZWO A;  3CTZ A;  1C23 A;  1WN1 A;  2P99 A;  3Q6D A;  2OKN A;  4OOK A;  4R60 A;  1A16 A;  3BIP A;  2Q94 A;  4HXX A;  1R58 A;  2GG9 A;  4Z7M A;  2EA4 A;  2GG0 A;  5D6F A;  2B3K A;  2BWS A;  4FLL A;  2Q95 A;  3PKE A;  4ZWP A;  1QZY A;  2BWX A;  2V3X A;  2Q93 A;  1XGO A;  2GGB A;  2G6P A;  2BH3 A;  1KQ9 A;  2GU6 A;  4FO8 A;  4S2T P;  3FMR A;  4U6Z A;  3L7G A;  2GU5 A;  2BWT A;  2ADU A;  1XGM A;  5CDL A;  5CLS A;  2DFI A;  1YW9 A;  5CDV A;  5FCH A;  4U6J A;  2BWY A;  2EVM A;  1YW8 A;  2BWU A;  1YJ3 A;  2GG2 A;  4IDY A;  1W2M A;  1B59 A;  2B3H A;  4JUQ A;  2GG3 A;  2EVC A;  2BHA A;  1R5H A;  4U69 A;  2Q92 A;  1W7V A;  2P9A A;  4S00 A;  2BHC A;  1CHM A;  3PKC A;  5CIK A;  2GG7 A;  1BN5 A;  1BOA A;  3IU9 A;  4PV4 A;  3D27 A;  2EA2 A;  1C24 A;  2GU7 A;  4U73 A;  1M35 A;  3ROR A;  1YVM A;  5JFR A;  1QXY A;  4B28 A;  4U70 A;  4IEC A;  4IPA A;  2MAT A;  3PKA A;  1Y1N A;  1PV9 A;  1WY2 A;  3PKB A;  2V3Z A;  4RZZ A;  4RGZ 1;  4A6W A;  1N51 A;  1YW7 A;  3CB5 A;  1XGS A;  4S01 A;  1WL9 A;  2V3Y A;  3RVA A;  4IKT A;  3FM3 A;  2NQ7 A;  1KP0 A;  2V6C A;  2B3L A;  1WLR A;  3BIQ A;  2BHD A;  2GGC A;  2NQ6 A;  3S6B A;  2Q8K A;  2P98 A;  3BIT A;  4U6C A;  4FUK A;  4A6V A;  3MX6 A;  2BHB A;  1C27 A;  4KM3 A;  2ZSG A;  4IF7 A;  4IKU A;  4QR8 A;  1WKM A;  4PNC A;  3PKD A;  1QXZ A;  2Q96 A;  3IU7 A;  2GU4 A;  3IG4 A;  2BWW A;  3L24 A;  4FO7 A;  2HOW A;  5D6E A;  3TAV A;  1KQ0 A;  4U6W A;  4MAT A;  1O0X A;  5CE6 A;  1WBQ A;  3CB6 A;  2EVO A;  2GZ5 A;  4U6E A;  4ZNG A;  1C21 A;  3FMQ A;  1R5G A; 
#chains in the Genus database with same CATH topology
 5FCF A;  4IKS A;  4EGE A;  2GG8 A;  1B6A A;  2IW2 A;  2BN7 A;  4ZWU A;  4FLK A;  5E5B A;  4FLI A;  4FLJ A;  2BWV A;  4U76 A;  1MAT A;  3IU8 A;  5JHU A;  4U71 A;  4IU6 A;  3TB5 A;  4IKR A;  1QXW A;  1WL6 A;  5JI6 A;  4RZY A;  4FKC A;  2GTX A;  2BB7 A;  5CNX A;  1XNZ A;  2GA2 A;  1XGN A;  5CDE A;  4U1B A;  1JAW A;  2OAZ A;  3MR1 A;  1C22 A;  2GG5 A;  4U75 A;  3MAT A;  4S2R P;  4ZWO A;  3CTZ A;  1C23 A;  1WN1 A;  2P99 A;  3Q6D A;  2OKN A;  4OOK A;  4R60 A;  1A16 A;  3BIP A;  2Q94 A;  4HXX A;  1R58 A;  2GG9 A;  4Z7M A;  2EA4 A;  2GG0 A;  5D6F A;  2B3K A;  2BWS A;  4FLL A;  2Q95 A;  3PKE A;  4ZWP A;  1QZY A;  2BWX A;  2V3X A;  2Q93 A;  1XGO A;  2GGB A;  2G6P A;  2BH3 A;  1KQ9 A;  2GU6 A;  4FO8 A;  4S2T P;  3FMR A;  4U6Z A;  3L7G A;  2GU5 A;  2BWT A;  2ADU A;  1XGM A;  5CDL A;  5CLS A;  2DFI A;  1YW9 A;  5CDV A;  5FCH A;  4U6J A;  2BWY A;  2EVM A;  1YW8 A;  2BWU A;  1YJ3 A;  2GG2 A;  4IDY A;  1W2M A;  1B59 A;  2B3H A;  4JUQ A;  2GG3 A;  2EVC A;  2BHA A;  1R5H A;  4U69 A;  2Q92 A;  1W7V A;  2P9A A;  4S00 A;  2BHC A;  1CHM A;  3PKC A;  5CIK A;  2GG7 A;  1BN5 A;  1BOA A;  3IU9 A;  4PV4 A;  3D27 A;  2EA2 A;  1C24 A;  2GU7 A;  4U73 A;  1M35 A;  3ROR A;  1YVM A;  5JFR A;  1QXY A;  4B28 A;  4U70 A;  4IEC A;  4IPA A;  2MAT A;  3PKA A;  1Y1N A;  1PV9 A;  1WY2 A;  3PKB A;  2V3Z A;  4RZZ A;  4RGZ 1;  4A6W A;  1N51 A;  1YW7 A;  3CB5 A;  1XGS A;  4S01 A;  1WL9 A;  2V3Y A;  3RVA A;  4IKT A;  3FM3 A;  2NQ7 A;  1KP0 A;  2V6C A;  2B3L A;  1WLR A;  3BIQ A;  2BHD A;  2GGC A;  2NQ6 A;  3S6B A;  2Q8K A;  2P98 A;  3BIT A;  4U6C A;  4FUK A;  4A6V A;  3MX6 A;  2BHB A;  1C27 A;  4KM3 A;  2ZSG A;  4IF7 A;  4IKU A;  4QR8 A;  1WKM A;  4PNC A;  3PKD A;  1QXZ A;  2Q96 A;  3IU7 A;  2GU4 A;  3IG4 A;  2BWW A;  3L24 A;  4FO7 A;  2HOW A;  5D6E A;  3TAV A;  1KQ0 A;  4U6W A;  4MAT A;  1O0X A;  5CE6 A;  1WBQ A;  3CB6 A;  2EVO A;  2GZ5 A;  4U6E A;  4ZNG A;  1C21 A;  3FMQ A;  1R5G A; 
#chains in the Genus database with same CATH homology
 5FCF A;  4IKS A;  4EGE A;  2GG8 A;  1B6A A;  2IW2 A;  2BN7 A;  4ZWU A;  4FLK A;  5E5B A;  4FLI A;  4FLJ A;  2BWV A;  4U76 A;  1MAT A;  3IU8 A;  5JHU A;  4U71 A;  4IU6 A;  3TB5 A;  4IKR A;  1QXW A;  1WL6 A;  5JI6 A;  4RZY A;  4FKC A;  2GTX A;  2BB7 A;  5CNX A;  1XNZ A;  2GA2 A;  1XGN A;  5CDE A;  4U1B A;  1JAW A;  2OAZ A;  3MR1 A;  1C22 A;  2GG5 A;  4U75 A;  3MAT A;  4S2R P;  4ZWO A;  3CTZ A;  1C23 A;  1WN1 A;  2P99 A;  3Q6D A;  2OKN A;  4OOK A;  4R60 A;  1A16 A;  3BIP A;  2Q94 A;  4HXX A;  1R58 A;  2GG9 A;  4Z7M A;  2EA4 A;  2GG0 A;  5D6F A;  2B3K A;  2BWS A;  4FLL A;  2Q95 A;  3PKE A;  4ZWP A;  1QZY A;  2BWX A;  2V3X A;  2Q93 A;  1XGO A;  2GGB A;  2G6P A;  2BH3 A;  1KQ9 A;  2GU6 A;  4FO8 A;  4S2T P;  3FMR A;  4U6Z A;  3L7G A;  2GU5 A;  2BWT A;  2ADU A;  1XGM A;  5CDL A;  5CLS A;  2DFI A;  1YW9 A;  5CDV A;  5FCH A;  4U6J A;  2BWY A;  2EVM A;  1YW8 A;  2BWU A;  1YJ3 A;  2GG2 A;  4IDY A;  1W2M A;  1B59 A;  2B3H A;  4JUQ A;  2GG3 A;  2EVC A;  2BHA A;  1R5H A;  4U69 A;  2Q92 A;  1W7V A;  2P9A A;  4S00 A;  2BHC A;  1CHM A;  3PKC A;  5CIK A;  2GG7 A;  1BN5 A;  1BOA A;  3IU9 A;  4PV4 A;  3D27 A;  2EA2 A;  1C24 A;  2GU7 A;  4U73 A;  1M35 A;  3ROR A;  1YVM A;  5JFR A;  1QXY A;  4B28 A;  4U70 A;  4IEC A;  4IPA A;  2MAT A;  3PKA A;  1Y1N A;  1PV9 A;  1WY2 A;  3PKB A;  2V3Z A;  4RZZ A;  4RGZ 1;  4A6W A;  1N51 A;  1YW7 A;  3CB5 A;  1XGS A;  4S01 A;  1WL9 A;  2V3Y A;  3RVA A;  4IKT A;  3FM3 A;  2NQ7 A;  1KP0 A;  2V6C A;  2B3L A;  1WLR A;  3BIQ A;  2BHD A;  2GGC A;  2NQ6 A;  3S6B A;  2Q8K A;  2P98 A;  3BIT A;  4U6C A;  4FUK A;  4A6V A;  3MX6 A;  2BHB A;  1C27 A;  4KM3 A;  2ZSG A;  4IF7 A;  4IKU A;  4QR8 A;  1WKM A;  4PNC A;  3PKD A;  1QXZ A;  2Q96 A;  3IU7 A;  2GU4 A;  3IG4 A;  2BWW A;  3L24 A;  4FO7 A;  2HOW A;  5D6E A;  3TAV A;  1KQ0 A;  4U6W A;  4MAT A;  1O0X A;  5CE6 A;  1WBQ A;  3CB6 A;  2EVO A;  2GZ5 A;  4U6E A;  4ZNG A;  1C21 A;  3FMQ A;  1R5G A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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