2EVMA

Crystal structure of methionine aminopeptidase in complex with 5-(2,5-dichlorophenyl)furan-2-carboxylic acid
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
259
structure length
259
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 86
structure length 259
sequence length 259
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evmA00
4U1BA 4U6CA 2GG8A 2Q92A 5CDLA 4PNCA 2EA2A 1WL9A 4U75A 1WY2A 4ZWOA 1QXWA 2V6CA 3BIPA 3TB5A 4U70A 5CDEA 3PKBA 2P9AA 5FCHA 2OAZA 4R60A 4U6EA 3IU8A 1R58A 1QXZA 2BWYA 2Q96A 3L24A 4IF7A 1M35A 1Y1NA 4B28A 2B3KA 3Q6DA 2BB7A 1C23A 2BHCA 3S6BA 1YVMA 2MATA 1YW9A 1A16A 1PV9A 1YW8A 3CB5A 2Q93A 4IU6A 1JAWA 2BWSA 4IECA 2NQ6A 2BHBA 2BHDA 2GA2A 4IKRA 4S2TP 1QZYA 3BITA 1KP0A 5FCFA 2GG0A 2GTXA 2GG9A 3PKCA 1W7VA 3IU9A 4RGZ1 1C22A 2IW2A 4FUKA 4S2RP 4U73A 5JFRA 1CHMA 4JUQA 2GU6A 2BWXA 1R5HA 1XGOA 1C27A 2GGBA 3IU7A 3L7GA 4PV4A 3RORA 3TAVA 3MR1A 4MATA 1WL6A 2DFIA 2ADUA 5CDVA 4FLIA 2EVMA 2BN7A 3FMRA 1B6AA 1R5GA 2B3HA 1XNZA 2GG5A 2Q94A 1YW7A 1WN1A 4IKUA 3IG4A 4U69A 2GU5A 4QR8A 2BWTA 4EGEA 1WKMA 1KQ0A 5CE6A 2BWWA 4OOKA 5E5BA 5D6FA 4RZZA 4IDYA 4FLJA 4U6JA 4ZWUA 2EVCA 3CTZA 2BHAA 4RZYA 2EVOA 1C21A 2EA4A 1BOAA 2GG3A 2GZ5A 2Q8KA 1KQ9A 4FO7A 5CNXA 3D27A 2GU7A 2OKNA 1XGSA 2GU4A 1XGMA 4S01A 2Q95A 4U6ZA 4A6VA 2ZSGA 1YJ3A 2HOWA 1XGNA 4U76A 4Z7MA 2GG7A 2P99A 3FM3A 4FO8A 2NQ7A 4FKCA 5JHUA 3MATA 1N51A 2V3YA 3PKEA 5CIKA 4A6WA 1C24A 4U6WA 4S00A 4KM3A 1MATA 4HXXA 1B59A 2BH3A 3BIQA 4ZNGA 2GG2A 3FMQA 1WBQA 3PKAA 4FLKA 2BWUA 2B3LA 5JI6A 2P98A 4IPAA 5CLSA 1O0XA 1QXYA 5D6EA 3CB6A 2V3XA 1BN5A 2BWVA 4IKTA 4FLLA 4ZWPA 3MX6A 2G6PA 3RVAA 2GGCA 1W2MA 2V3ZA 4U71A 3PKDA 4IKSA 1WLRA
chains in the Genus database with same CATH superfamily
4U1BA 4U6CA 2GG8A 2Q92A 5CDLA 4PNCA 2EA2A 1WL9A 4U75A 1WY2A 4ZWOA 1QXWA 2V6CA 3BIPA 3TB5A 4U70A 5CDEA 3PKBA 2P9AA 5FCHA 2OAZA 4R60A 4U6EA 3IU8A 1R58A 1QXZA 2BWYA 2Q96A 3L24A 4IF7A 1M35A 1Y1NA 4B28A 2B3KA 3Q6DA 2BB7A 1C23A 2BHCA 3S6BA 1YVMA 2MATA 1YW9A 1A16A 1PV9A 1YW8A 3CB5A 2Q93A 4IU6A 1JAWA 2BWSA 4IECA 2NQ6A 2BHBA 2BHDA 2GA2A 4IKRA 4S2TP 1QZYA 3BITA 1KP0A 5FCFA 2GG0A 2GTXA 2GG9A 3PKCA 1W7VA 3IU9A 4RGZ1 1C22A 2IW2A 4FUKA 4S2RP 4U73A 5JFRA 1CHMA 4JUQA 2GU6A 2BWXA 1R5HA 1XGOA 1C27A 2GGBA 3IU7A 3L7GA 4PV4A 3RORA 3TAVA 3MR1A 4MATA 1WL6A 2DFIA 2ADUA 5CDVA 4FLIA 2EVMA 2BN7A 3FMRA 1B6AA 1R5GA 2B3HA 1XNZA 2GG5A 2Q94A 1YW7A 1WN1A 4IKUA 3IG4A 4U69A 2GU5A 4QR8A 2BWTA 4EGEA 1WKMA 1KQ0A 5CE6A 2BWWA 4OOKA 5E5BA 5D6FA 4RZZA 4IDYA 4FLJA 4U6JA 4ZWUA 2EVCA 3CTZA 2BHAA 4RZYA 2EVOA 1C21A 2EA4A 1BOAA 2GG3A 2GZ5A 2Q8KA 1KQ9A 4FO7A 5CNXA 3D27A 2GU7A 2OKNA 1XGSA 2GU4A 1XGMA 4S01A 2Q95A 4U6ZA 4A6VA 2ZSGA 1YJ3A 2HOWA 1XGNA 4U76A 4Z7MA 2GG7A 2P99A 3FM3A 4FO8A 2NQ7A 4FKCA 5JHUA 3MATA 1N51A 2V3YA 3PKEA 5CIKA 4A6WA 1C24A 4U6WA 4S00A 4KM3A 1MATA 4HXXA 1B59A 2BH3A 3BIQA 4ZNGA 2GG2A 3FMQA 1WBQA 3PKAA 4FLKA 2BWUA 2B3LA 5JI6A 2P98A 4IPAA 5CLSA 1O0XA 1QXYA 5D6EA 3CB6A 2V3XA 1BN5A 2BWVA 4IKTA 4FLLA 4ZWPA 3MX6A 2G6PA 3RVAA 2GGCA 1W2MA 2V3ZA 4U71A 3PKDA 4IKSA 1WLRA
chains in the Genus database with same CATH topology
4U1BA 4U6CA 2GG8A 2Q92A 5CDLA 4PNCA 2EA2A 1WL9A 4U75A 1WY2A 4ZWOA 1QXWA 2V6CA 3BIPA 3TB5A 4U70A 5CDEA 3PKBA 2P9AA 5FCHA 2OAZA 4R60A 4U6EA 3IU8A 1R58A 1QXZA 2BWYA 2Q96A 3L24A 4IF7A 1M35A 1Y1NA 4B28A 2B3KA 3Q6DA 2BB7A 1C23A 2BHCA 3S6BA 1YVMA 2MATA 1YW9A 1A16A 1PV9A 1YW8A 3CB5A 2Q93A 4IU6A 1JAWA 2BWSA 4IECA 2NQ6A 2BHBA 2BHDA 2GA2A 4IKRA 4S2TP 1QZYA 3BITA 1KP0A 5FCFA 2GG0A 2GTXA 2GG9A 3PKCA 1W7VA 3IU9A 4RGZ1 1C22A 2IW2A 4FUKA 4S2RP 4U73A 5JFRA 1CHMA 4JUQA 2GU6A 2BWXA 1R5HA 1XGOA 1C27A 2GGBA 3IU7A 3L7GA 4PV4A 3RORA 3TAVA 3MR1A 4MATA 1WL6A 2DFIA 2ADUA 5CDVA 4FLIA 2EVMA 2BN7A 3FMRA 1B6AA 1R5GA 2B3HA 1XNZA 2GG5A 2Q94A 1YW7A 1WN1A 4IKUA 3IG4A 4U69A 2GU5A 4QR8A 2BWTA 4EGEA 1WKMA 1KQ0A 5CE6A 2BWWA 4OOKA 5E5BA 5D6FA 4RZZA 4IDYA 4FLJA 4U6JA 4ZWUA 2EVCA 3CTZA 2BHAA 4RZYA 2EVOA 1C21A 2EA4A 1BOAA 2GG3A 2GZ5A 2Q8KA 1KQ9A 4FO7A 5CNXA 3D27A 2GU7A 2OKNA 1XGSA 2GU4A 1XGMA 4S01A 2Q95A 4U6ZA 4A6VA 2ZSGA 1YJ3A 2HOWA 1XGNA 4U76A 4Z7MA 2GG7A 2P99A 3FM3A 4FO8A 2NQ7A 4FKCA 5JHUA 3MATA 1N51A 2V3YA 3PKEA 5CIKA 4A6WA 1C24A 4U6WA 4S00A 4KM3A 1MATA 4HXXA 1B59A 2BH3A 3BIQA 4ZNGA 2GG2A 3FMQA 1WBQA 3PKAA 4FLKA 2BWUA 2B3LA 5JI6A 2P98A 4IPAA 5CLSA 1O0XA 1QXYA 5D6EA 3CB6A 2V3XA 1BN5A 2BWVA 4IKTA 4FLLA 4ZWPA 3MX6A 2G6PA 3RVAA 2GGCA 1W2MA 2V3ZA 4U71A 3PKDA 4IKSA 1WLRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U1B A;  4U6C A;  2GG8 A;  2Q92 A;  5CDL A;  4PNC A;  2EA2 A;  1WL9 A;  4U75 A;  1WY2 A;  4ZWO A;  1QXW A;  2V6C A;  3BIP A;  3TB5 A;  4U70 A;  5CDE A;  3PKB A;  2P9A A;  5FCH A;  2OAZ A;  4R60 A;  4U6E A;  3IU8 A;  1R58 A;  1QXZ A;  2BWY A;  2Q96 A;  3L24 A;  4IF7 A;  1M35 A;  1Y1N A;  4B28 A;  2B3K A;  3Q6D A;  2BB7 A;  1C23 A;  2BHC A;  3S6B A;  1YVM A;  2MAT A;  1YW9 A;  1A16 A;  1PV9 A;  1YW8 A;  3CB5 A;  2Q93 A;  4IU6 A;  1JAW A;  2BWS A;  4IEC A;  2NQ6 A;  2BHB A;  2BHD A;  2GA2 A;  4IKR A;  4S2T P;  1QZY A;  3BIT A;  1KP0 A;  5FCF A;  2GG0 A;  2GTX A;  2GG9 A;  3PKC A;  1W7V A;  3IU9 A;  4RGZ 1;  1C22 A;  2IW2 A;  4FUK A;  4S2R P;  4U73 A;  5JFR A;  1CHM A;  4JUQ A;  2GU6 A;  2BWX A;  1R5H A;  1XGO A;  1C27 A;  2GGB A;  3IU7 A;  3L7G A;  4PV4 A;  3ROR A;  3TAV A;  3MR1 A;  4MAT A;  1WL6 A;  2DFI A;  2ADU A;  5CDV A;  4FLI A;  2EVM A;  2BN7 A;  3FMR A;  1B6A A;  1R5G A;  2B3H A;  1XNZ A;  2GG5 A;  2Q94 A;  1YW7 A;  1WN1 A;  4IKU A;  3IG4 A;  4U69 A;  2GU5 A;  4QR8 A;  2BWT A;  4EGE A;  1WKM A;  1KQ0 A;  5CE6 A;  2BWW A;  4OOK A;  5E5B A;  5D6F A;  4RZZ A;  4IDY A;  4FLJ A;  4U6J A;  4ZWU A;  2EVC A;  3CTZ A;  2BHA A;  4RZY A;  2EVO A;  1C21 A;  2EA4 A;  1BOA A;  2GG3 A;  2GZ5 A;  2Q8K A;  1KQ9 A;  4FO7 A;  5CNX A;  3D27 A;  2GU7 A;  2OKN A;  1XGS A;  2GU4 A;  1XGM A;  4S01 A;  2Q95 A;  4U6Z A;  4A6V A;  2ZSG A;  1YJ3 A;  2HOW A;  1XGN A;  4U76 A;  4Z7M A;  2GG7 A;  2P99 A;  3FM3 A;  4FO8 A;  2NQ7 A;  4FKC A;  5JHU A;  3MAT A;  1N51 A;  2V3Y A;  3PKE A;  5CIK A;  4A6W A;  1C24 A;  4U6W A;  4S00 A;  4KM3 A;  1MAT A;  4HXX A;  1B59 A;  2BH3 A;  3BIQ A;  4ZNG A;  2GG2 A;  3FMQ A;  1WBQ A;  3PKA A;  4FLK A;  2BWU A;  2B3L A;  5JI6 A;  2P98 A;  4IPA A;  5CLS A;  1O0X A;  1QXY A;  5D6E A;  3CB6 A;  2V3X A;  1BN5 A;  2BWV A;  4IKT A;  4FLL A;  4ZWP A;  3MX6 A;  2G6P A;  3RVA A;  2GGC A;  1W2M A;  2V3Z A;  4U71 A;  3PKD A;  4IKS A;  1WLR A; 
#chains in the Genus database with same CATH topology
 4U1B A;  4U6C A;  2GG8 A;  2Q92 A;  5CDL A;  4PNC A;  2EA2 A;  1WL9 A;  4U75 A;  1WY2 A;  4ZWO A;  1QXW A;  2V6C A;  3BIP A;  3TB5 A;  4U70 A;  5CDE A;  3PKB A;  2P9A A;  5FCH A;  2OAZ A;  4R60 A;  4U6E A;  3IU8 A;  1R58 A;  1QXZ A;  2BWY A;  2Q96 A;  3L24 A;  4IF7 A;  1M35 A;  1Y1N A;  4B28 A;  2B3K A;  3Q6D A;  2BB7 A;  1C23 A;  2BHC A;  3S6B A;  1YVM A;  2MAT A;  1YW9 A;  1A16 A;  1PV9 A;  1YW8 A;  3CB5 A;  2Q93 A;  4IU6 A;  1JAW A;  2BWS A;  4IEC A;  2NQ6 A;  2BHB A;  2BHD A;  2GA2 A;  4IKR A;  4S2T P;  1QZY A;  3BIT A;  1KP0 A;  5FCF A;  2GG0 A;  2GTX A;  2GG9 A;  3PKC A;  1W7V A;  3IU9 A;  4RGZ 1;  1C22 A;  2IW2 A;  4FUK A;  4S2R P;  4U73 A;  5JFR A;  1CHM A;  4JUQ A;  2GU6 A;  2BWX A;  1R5H A;  1XGO A;  1C27 A;  2GGB A;  3IU7 A;  3L7G A;  4PV4 A;  3ROR A;  3TAV A;  3MR1 A;  4MAT A;  1WL6 A;  2DFI A;  2ADU A;  5CDV A;  4FLI A;  2EVM A;  2BN7 A;  3FMR A;  1B6A A;  1R5G A;  2B3H A;  1XNZ A;  2GG5 A;  2Q94 A;  1YW7 A;  1WN1 A;  4IKU A;  3IG4 A;  4U69 A;  2GU5 A;  4QR8 A;  2BWT A;  4EGE A;  1WKM A;  1KQ0 A;  5CE6 A;  2BWW A;  4OOK A;  5E5B A;  5D6F A;  4RZZ A;  4IDY A;  4FLJ A;  4U6J A;  4ZWU A;  2EVC A;  3CTZ A;  2BHA A;  4RZY A;  2EVO A;  1C21 A;  2EA4 A;  1BOA A;  2GG3 A;  2GZ5 A;  2Q8K A;  1KQ9 A;  4FO7 A;  5CNX A;  3D27 A;  2GU7 A;  2OKN A;  1XGS A;  2GU4 A;  1XGM A;  4S01 A;  2Q95 A;  4U6Z A;  4A6V A;  2ZSG A;  1YJ3 A;  2HOW A;  1XGN A;  4U76 A;  4Z7M A;  2GG7 A;  2P99 A;  3FM3 A;  4FO8 A;  2NQ7 A;  4FKC A;  5JHU A;  3MAT A;  1N51 A;  2V3Y A;  3PKE A;  5CIK A;  4A6W A;  1C24 A;  4U6W A;  4S00 A;  4KM3 A;  1MAT A;  4HXX A;  1B59 A;  2BH3 A;  3BIQ A;  4ZNG A;  2GG2 A;  3FMQ A;  1WBQ A;  3PKA A;  4FLK A;  2BWU A;  2B3L A;  5JI6 A;  2P98 A;  4IPA A;  5CLS A;  1O0X A;  1QXY A;  5D6E A;  3CB6 A;  2V3X A;  1BN5 A;  2BWV A;  4IKT A;  4FLL A;  4ZWP A;  3MX6 A;  2G6P A;  3RVA A;  2GGC A;  1W2M A;  2V3Z A;  4U71 A;  3PKD A;  4IKS A;  1WLR A; 
#chains in the Genus database with same CATH homology
 4U1B A;  4U6C A;  2GG8 A;  2Q92 A;  5CDL A;  4PNC A;  2EA2 A;  1WL9 A;  4U75 A;  1WY2 A;  4ZWO A;  1QXW A;  2V6C A;  3BIP A;  3TB5 A;  4U70 A;  5CDE A;  3PKB A;  2P9A A;  5FCH A;  2OAZ A;  4R60 A;  4U6E A;  3IU8 A;  1R58 A;  1QXZ A;  2BWY A;  2Q96 A;  3L24 A;  4IF7 A;  1M35 A;  1Y1N A;  4B28 A;  2B3K A;  3Q6D A;  2BB7 A;  1C23 A;  2BHC A;  3S6B A;  1YVM A;  2MAT A;  1YW9 A;  1A16 A;  1PV9 A;  1YW8 A;  3CB5 A;  2Q93 A;  4IU6 A;  1JAW A;  2BWS A;  4IEC A;  2NQ6 A;  2BHB A;  2BHD A;  2GA2 A;  4IKR A;  4S2T P;  1QZY A;  3BIT A;  1KP0 A;  5FCF A;  2GG0 A;  2GTX A;  2GG9 A;  3PKC A;  1W7V A;  3IU9 A;  4RGZ 1;  1C22 A;  2IW2 A;  4FUK A;  4S2R P;  4U73 A;  5JFR A;  1CHM A;  4JUQ A;  2GU6 A;  2BWX A;  1R5H A;  1XGO A;  1C27 A;  2GGB A;  3IU7 A;  3L7G A;  4PV4 A;  3ROR A;  3TAV A;  3MR1 A;  4MAT A;  1WL6 A;  2DFI A;  2ADU A;  5CDV A;  4FLI A;  2EVM A;  2BN7 A;  3FMR A;  1B6A A;  1R5G A;  2B3H A;  1XNZ A;  2GG5 A;  2Q94 A;  1YW7 A;  1WN1 A;  4IKU A;  3IG4 A;  4U69 A;  2GU5 A;  4QR8 A;  2BWT A;  4EGE A;  1WKM A;  1KQ0 A;  5CE6 A;  2BWW A;  4OOK A;  5E5B A;  5D6F A;  4RZZ A;  4IDY A;  4FLJ A;  4U6J A;  4ZWU A;  2EVC A;  3CTZ A;  2BHA A;  4RZY A;  2EVO A;  1C21 A;  2EA4 A;  1BOA A;  2GG3 A;  2GZ5 A;  2Q8K A;  1KQ9 A;  4FO7 A;  5CNX A;  3D27 A;  2GU7 A;  2OKN A;  1XGS A;  2GU4 A;  1XGM A;  4S01 A;  2Q95 A;  4U6Z A;  4A6V A;  2ZSG A;  1YJ3 A;  2HOW A;  1XGN A;  4U76 A;  4Z7M A;  2GG7 A;  2P99 A;  3FM3 A;  4FO8 A;  2NQ7 A;  4FKC A;  5JHU A;  3MAT A;  1N51 A;  2V3Y A;  3PKE A;  5CIK A;  4A6W A;  1C24 A;  4U6W A;  4S00 A;  4KM3 A;  1MAT A;  4HXX A;  1B59 A;  2BH3 A;  3BIQ A;  4ZNG A;  2GG2 A;  3FMQ A;  1WBQ A;  3PKA A;  4FLK A;  2BWU A;  2B3L A;  5JI6 A;  2P98 A;  4IPA A;  5CLS A;  1O0X A;  1QXY A;  5D6E A;  3CB6 A;  2V3X A;  1BN5 A;  2BWV A;  4IKT A;  4FLL A;  4ZWP A;  3MX6 A;  2G6P A;  3RVA A;  2GGC A;  1W2M A;  2V3Z A;  4U71 A;  3PKD A;  4IKS A;  1WLR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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