2EVOA

Crystal structure of methionine amino peptidase in complex with n-cyclopentyl-n-(thiazol-2-yl)oxalamide
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
260
structure length
260
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of metalloform-selective inhibition of methionine aminopeptidase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 88
structure length 260
sequence length 260
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2005-10-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2evoA00
2BHBA 2Q95A 4PNCA 2GG0A 4A6VA 4IKRA 4IKUA 1R5HA 4QR8A 4ZNGA 1YW7A 3TB5A 2OKNA 2Q93A 5JFRA 1YJ3A 1YW8A 2EVCA 4IF7A 3PKBA 3CTZA 1C23A 1CHMA 1BN5A 4RZYA 3BITA 1WBQA 1B6AA 5CIKA 2DFIA 2BHDA 2B3HA 2GGCA 5CDVA 4U6CA 3FMQA 2GTXA 5JI6A 1PV9A 4B28A 3MX6A 5D6EA 1W2MA 3RVAA 4OOKA 1C27A 4ZWOA 4KM3A 4S00A 4S2RP 5CLSA 4Z7MA 2IW2A 2BWSA 1O0XA 1C22A 2Q94A 3CB5A 2BHAA 2GGBA 1A16A 4S01A 1WL6A 2BN7A 2GU5A 1QXWA 1R58A 2OAZA 1XGNA 1WLRA 3Q6DA 2P9AA 4FKCA 4FLLA 4JUQA 3BIQA 2NQ6A 4FLKA 2BWYA 1WKMA 2GU7A 3PKCA 3BIPA 2Q8KA 2V3ZA 1KQ0A 1W7VA 3IU8A 3L24A 4R60A 2GG7A 2GA2A 3PKAA 2P99A 2ADUA 4A6WA 4FLJA 2EA2A 2EA4A 5FCFA 4MATA 3RORA 4S2TP 5CNXA 2HOWA 2B3LA 4IECA 1YVMA 1R5GA 1WY2A 2Q96A 4IU6A 2BHCA 4U6EA 4U71A 2BWUA 2BWTA 2EVOA 4U75A 4ZWUA 4FLIA 3IG4A 2V3YA 4U73A 3S6BA 5D6FA 1KP0A 2BWVA 3MATA 5E5BA 4U69A 1XGSA 2MATA 4ZWPA 2BWXA 3IU7A 4FO7A 2GG9A 5JHUA 2GG5A 1XNZA 2GG2A 3CB6A 4HXXA 4IKTA 4PV4A 4U1BA 5FCHA 3FMRA 1C21A 4RGZ1 3TAVA 5CE6A 1N51A 1BOAA 4FUKA 2Q92A 1MATA 2V6CA 2NQ7A 1B59A 1KQ9A 4IKSA 1QXYA 4U6JA 1WN1A 2G6PA 4IDYA 4IPAA 2GZ5A 2P98A 1JAWA 3MR1A 3L7GA 2BH3A 4FO8A 4EGEA 2GU4A 4U6ZA 1M35A 4U6WA 2BB7A 1YW9A 2V3XA 1QZYA 4U70A 4U76A 3PKEA 2B3KA 1XGOA 4RZZA 1Y1NA 1WL9A 1XGMA 1QXZA 3PKDA 1C24A 2GU6A 5CDEA 3FM3A 2GG3A 3D27A 2EVMA 3IU9A 5CDLA 2BWWA 2ZSGA 2GG8A
chains in the Genus database with same CATH superfamily
2BHBA 2Q95A 4PNCA 2GG0A 4A6VA 4IKRA 4IKUA 1R5HA 4QR8A 4ZNGA 1YW7A 3TB5A 2OKNA 2Q93A 5JFRA 1YJ3A 1YW8A 2EVCA 4IF7A 3PKBA 3CTZA 1C23A 1CHMA 1BN5A 4RZYA 3BITA 1WBQA 1B6AA 5CIKA 2DFIA 2BHDA 2B3HA 2GGCA 5CDVA 4U6CA 3FMQA 2GTXA 5JI6A 1PV9A 4B28A 3MX6A 5D6EA 1W2MA 3RVAA 4OOKA 1C27A 4ZWOA 4KM3A 4S00A 4S2RP 5CLSA 4Z7MA 2IW2A 2BWSA 1O0XA 1C22A 2Q94A 3CB5A 2BHAA 2GGBA 1A16A 4S01A 1WL6A 2BN7A 2GU5A 1QXWA 1R58A 2OAZA 1XGNA 1WLRA 3Q6DA 2P9AA 4FKCA 4FLLA 4JUQA 3BIQA 2NQ6A 4FLKA 2BWYA 1WKMA 2GU7A 3PKCA 3BIPA 2Q8KA 2V3ZA 1KQ0A 1W7VA 3IU8A 3L24A 4R60A 2GG7A 2GA2A 3PKAA 2P99A 2ADUA 4A6WA 4FLJA 2EA2A 2EA4A 5FCFA 4MATA 3RORA 4S2TP 5CNXA 2HOWA 2B3LA 4IECA 1YVMA 1R5GA 1WY2A 2Q96A 4IU6A 2BHCA 4U6EA 4U71A 2BWUA 2BWTA 2EVOA 4U75A 4ZWUA 4FLIA 3IG4A 2V3YA 4U73A 3S6BA 5D6FA 1KP0A 2BWVA 3MATA 5E5BA 4U69A 1XGSA 2MATA 4ZWPA 2BWXA 3IU7A 4FO7A 2GG9A 5JHUA 2GG5A 1XNZA 2GG2A 3CB6A 4HXXA 4IKTA 4PV4A 4U1BA 5FCHA 3FMRA 1C21A 4RGZ1 3TAVA 5CE6A 1N51A 1BOAA 4FUKA 2Q92A 1MATA 2V6CA 2NQ7A 1B59A 1KQ9A 4IKSA 1QXYA 4U6JA 1WN1A 2G6PA 4IDYA 4IPAA 2GZ5A 2P98A 1JAWA 3MR1A 3L7GA 2BH3A 4FO8A 4EGEA 2GU4A 4U6ZA 1M35A 4U6WA 2BB7A 1YW9A 2V3XA 1QZYA 4U70A 4U76A 3PKEA 2B3KA 1XGOA 4RZZA 1Y1NA 1WL9A 1XGMA 1QXZA 3PKDA 1C24A 2GU6A 5CDEA 3FM3A 2GG3A 3D27A 2EVMA 3IU9A 5CDLA 2BWWA 2ZSGA 2GG8A
chains in the Genus database with same CATH topology
2BHBA 2Q95A 4PNCA 2GG0A 4A6VA 4IKRA 4IKUA 1R5HA 4QR8A 4ZNGA 1YW7A 3TB5A 2OKNA 2Q93A 5JFRA 1YJ3A 1YW8A 2EVCA 4IF7A 3PKBA 3CTZA 1C23A 1CHMA 1BN5A 4RZYA 3BITA 1WBQA 1B6AA 5CIKA 2DFIA 2BHDA 2B3HA 2GGCA 5CDVA 4U6CA 3FMQA 2GTXA 5JI6A 1PV9A 4B28A 3MX6A 5D6EA 1W2MA 3RVAA 4OOKA 1C27A 4ZWOA 4KM3A 4S00A 4S2RP 5CLSA 4Z7MA 2IW2A 2BWSA 1O0XA 1C22A 2Q94A 3CB5A 2BHAA 2GGBA 1A16A 4S01A 1WL6A 2BN7A 2GU5A 1QXWA 1R58A 2OAZA 1XGNA 1WLRA 3Q6DA 2P9AA 4FKCA 4FLLA 4JUQA 3BIQA 2NQ6A 4FLKA 2BWYA 1WKMA 2GU7A 3PKCA 3BIPA 2Q8KA 2V3ZA 1KQ0A 1W7VA 3IU8A 3L24A 4R60A 2GG7A 2GA2A 3PKAA 2P99A 2ADUA 4A6WA 4FLJA 2EA2A 2EA4A 5FCFA 4MATA 3RORA 4S2TP 5CNXA 2HOWA 2B3LA 4IECA 1YVMA 1R5GA 1WY2A 2Q96A 4IU6A 2BHCA 4U6EA 4U71A 2BWUA 2BWTA 2EVOA 4U75A 4ZWUA 4FLIA 3IG4A 2V3YA 4U73A 3S6BA 5D6FA 1KP0A 2BWVA 3MATA 5E5BA 4U69A 1XGSA 2MATA 4ZWPA 2BWXA 3IU7A 4FO7A 2GG9A 5JHUA 2GG5A 1XNZA 2GG2A 3CB6A 4HXXA 4IKTA 4PV4A 4U1BA 5FCHA 3FMRA 1C21A 4RGZ1 3TAVA 5CE6A 1N51A 1BOAA 4FUKA 2Q92A 1MATA 2V6CA 2NQ7A 1B59A 1KQ9A 4IKSA 1QXYA 4U6JA 1WN1A 2G6PA 4IDYA 4IPAA 2GZ5A 2P98A 1JAWA 3MR1A 3L7GA 2BH3A 4FO8A 4EGEA 2GU4A 4U6ZA 1M35A 4U6WA 2BB7A 1YW9A 2V3XA 1QZYA 4U70A 4U76A 3PKEA 2B3KA 1XGOA 4RZZA 1Y1NA 1WL9A 1XGMA 1QXZA 3PKDA 1C24A 2GU6A 5CDEA 3FM3A 2GG3A 3D27A 2EVMA 3IU9A 5CDLA 2BWWA 2ZSGA 2GG8A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BHB A;  2Q95 A;  4PNC A;  2GG0 A;  4A6V A;  4IKR A;  4IKU A;  1R5H A;  4QR8 A;  4ZNG A;  1YW7 A;  3TB5 A;  2OKN A;  2Q93 A;  5JFR A;  1YJ3 A;  1YW8 A;  2EVC A;  4IF7 A;  3PKB A;  3CTZ A;  1C23 A;  1CHM A;  1BN5 A;  4RZY A;  3BIT A;  1WBQ A;  1B6A A;  5CIK A;  2DFI A;  2BHD A;  2B3H A;  2GGC A;  5CDV A;  4U6C A;  3FMQ A;  2GTX A;  5JI6 A;  1PV9 A;  4B28 A;  3MX6 A;  5D6E A;  1W2M A;  3RVA A;  4OOK A;  1C27 A;  4ZWO A;  4KM3 A;  4S00 A;  4S2R P;  5CLS A;  4Z7M A;  2IW2 A;  2BWS A;  1O0X A;  1C22 A;  2Q94 A;  3CB5 A;  2BHA A;  2GGB A;  1A16 A;  4S01 A;  1WL6 A;  2BN7 A;  2GU5 A;  1QXW A;  1R58 A;  2OAZ A;  1XGN A;  1WLR A;  3Q6D A;  2P9A A;  4FKC A;  4FLL A;  4JUQ A;  3BIQ A;  2NQ6 A;  4FLK A;  2BWY A;  1WKM A;  2GU7 A;  3PKC A;  3BIP A;  2Q8K A;  2V3Z A;  1KQ0 A;  1W7V A;  3IU8 A;  3L24 A;  4R60 A;  2GG7 A;  2GA2 A;  3PKA A;  2P99 A;  2ADU A;  4A6W A;  4FLJ A;  2EA2 A;  2EA4 A;  5FCF A;  4MAT A;  3ROR A;  4S2T P;  5CNX A;  2HOW A;  2B3L A;  4IEC A;  1YVM A;  1R5G A;  1WY2 A;  2Q96 A;  4IU6 A;  2BHC A;  4U6E A;  4U71 A;  2BWU A;  2BWT A;  2EVO A;  4U75 A;  4ZWU A;  4FLI A;  3IG4 A;  2V3Y A;  4U73 A;  3S6B A;  5D6F A;  1KP0 A;  2BWV A;  3MAT A;  5E5B A;  4U69 A;  1XGS A;  2MAT A;  4ZWP A;  2BWX A;  3IU7 A;  4FO7 A;  2GG9 A;  5JHU A;  2GG5 A;  1XNZ A;  2GG2 A;  3CB6 A;  4HXX A;  4IKT A;  4PV4 A;  4U1B A;  5FCH A;  3FMR A;  1C21 A;  4RGZ 1;  3TAV A;  5CE6 A;  1N51 A;  1BOA A;  4FUK A;  2Q92 A;  1MAT A;  2V6C A;  2NQ7 A;  1B59 A;  1KQ9 A;  4IKS A;  1QXY A;  4U6J A;  1WN1 A;  2G6P A;  4IDY A;  4IPA A;  2GZ5 A;  2P98 A;  1JAW A;  3MR1 A;  3L7G A;  2BH3 A;  4FO8 A;  4EGE A;  2GU4 A;  4U6Z A;  1M35 A;  4U6W A;  2BB7 A;  1YW9 A;  2V3X A;  1QZY A;  4U70 A;  4U76 A;  3PKE A;  2B3K A;  1XGO A;  4RZZ A;  1Y1N A;  1WL9 A;  1XGM A;  1QXZ A;  3PKD A;  1C24 A;  2GU6 A;  5CDE A;  3FM3 A;  2GG3 A;  3D27 A;  2EVM A;  3IU9 A;  5CDL A;  2BWW A;  2ZSG A;  2GG8 A; 
#chains in the Genus database with same CATH topology
 2BHB A;  2Q95 A;  4PNC A;  2GG0 A;  4A6V A;  4IKR A;  4IKU A;  1R5H A;  4QR8 A;  4ZNG A;  1YW7 A;  3TB5 A;  2OKN A;  2Q93 A;  5JFR A;  1YJ3 A;  1YW8 A;  2EVC A;  4IF7 A;  3PKB A;  3CTZ A;  1C23 A;  1CHM A;  1BN5 A;  4RZY A;  3BIT A;  1WBQ A;  1B6A A;  5CIK A;  2DFI A;  2BHD A;  2B3H A;  2GGC A;  5CDV A;  4U6C A;  3FMQ A;  2GTX A;  5JI6 A;  1PV9 A;  4B28 A;  3MX6 A;  5D6E A;  1W2M A;  3RVA A;  4OOK A;  1C27 A;  4ZWO A;  4KM3 A;  4S00 A;  4S2R P;  5CLS A;  4Z7M A;  2IW2 A;  2BWS A;  1O0X A;  1C22 A;  2Q94 A;  3CB5 A;  2BHA A;  2GGB A;  1A16 A;  4S01 A;  1WL6 A;  2BN7 A;  2GU5 A;  1QXW A;  1R58 A;  2OAZ A;  1XGN A;  1WLR A;  3Q6D A;  2P9A A;  4FKC A;  4FLL A;  4JUQ A;  3BIQ A;  2NQ6 A;  4FLK A;  2BWY A;  1WKM A;  2GU7 A;  3PKC A;  3BIP A;  2Q8K A;  2V3Z A;  1KQ0 A;  1W7V A;  3IU8 A;  3L24 A;  4R60 A;  2GG7 A;  2GA2 A;  3PKA A;  2P99 A;  2ADU A;  4A6W A;  4FLJ A;  2EA2 A;  2EA4 A;  5FCF A;  4MAT A;  3ROR A;  4S2T P;  5CNX A;  2HOW A;  2B3L A;  4IEC A;  1YVM A;  1R5G A;  1WY2 A;  2Q96 A;  4IU6 A;  2BHC A;  4U6E A;  4U71 A;  2BWU A;  2BWT A;  2EVO A;  4U75 A;  4ZWU A;  4FLI A;  3IG4 A;  2V3Y A;  4U73 A;  3S6B A;  5D6F A;  1KP0 A;  2BWV A;  3MAT A;  5E5B A;  4U69 A;  1XGS A;  2MAT A;  4ZWP A;  2BWX A;  3IU7 A;  4FO7 A;  2GG9 A;  5JHU A;  2GG5 A;  1XNZ A;  2GG2 A;  3CB6 A;  4HXX A;  4IKT A;  4PV4 A;  4U1B A;  5FCH A;  3FMR A;  1C21 A;  4RGZ 1;  3TAV A;  5CE6 A;  1N51 A;  1BOA A;  4FUK A;  2Q92 A;  1MAT A;  2V6C A;  2NQ7 A;  1B59 A;  1KQ9 A;  4IKS A;  1QXY A;  4U6J A;  1WN1 A;  2G6P A;  4IDY A;  4IPA A;  2GZ5 A;  2P98 A;  1JAW A;  3MR1 A;  3L7G A;  2BH3 A;  4FO8 A;  4EGE A;  2GU4 A;  4U6Z A;  1M35 A;  4U6W A;  2BB7 A;  1YW9 A;  2V3X A;  1QZY A;  4U70 A;  4U76 A;  3PKE A;  2B3K A;  1XGO A;  4RZZ A;  1Y1N A;  1WL9 A;  1XGM A;  1QXZ A;  3PKD A;  1C24 A;  2GU6 A;  5CDE A;  3FM3 A;  2GG3 A;  3D27 A;  2EVM A;  3IU9 A;  5CDL A;  2BWW A;  2ZSG A;  2GG8 A; 
#chains in the Genus database with same CATH homology
 2BHB A;  2Q95 A;  4PNC A;  2GG0 A;  4A6V A;  4IKR A;  4IKU A;  1R5H A;  4QR8 A;  4ZNG A;  1YW7 A;  3TB5 A;  2OKN A;  2Q93 A;  5JFR A;  1YJ3 A;  1YW8 A;  2EVC A;  4IF7 A;  3PKB A;  3CTZ A;  1C23 A;  1CHM A;  1BN5 A;  4RZY A;  3BIT A;  1WBQ A;  1B6A A;  5CIK A;  2DFI A;  2BHD A;  2B3H A;  2GGC A;  5CDV A;  4U6C A;  3FMQ A;  2GTX A;  5JI6 A;  1PV9 A;  4B28 A;  3MX6 A;  5D6E A;  1W2M A;  3RVA A;  4OOK A;  1C27 A;  4ZWO A;  4KM3 A;  4S00 A;  4S2R P;  5CLS A;  4Z7M A;  2IW2 A;  2BWS A;  1O0X A;  1C22 A;  2Q94 A;  3CB5 A;  2BHA A;  2GGB A;  1A16 A;  4S01 A;  1WL6 A;  2BN7 A;  2GU5 A;  1QXW A;  1R58 A;  2OAZ A;  1XGN A;  1WLR A;  3Q6D A;  2P9A A;  4FKC A;  4FLL A;  4JUQ A;  3BIQ A;  2NQ6 A;  4FLK A;  2BWY A;  1WKM A;  2GU7 A;  3PKC A;  3BIP A;  2Q8K A;  2V3Z A;  1KQ0 A;  1W7V A;  3IU8 A;  3L24 A;  4R60 A;  2GG7 A;  2GA2 A;  3PKA A;  2P99 A;  2ADU A;  4A6W A;  4FLJ A;  2EA2 A;  2EA4 A;  5FCF A;  4MAT A;  3ROR A;  4S2T P;  5CNX A;  2HOW A;  2B3L A;  4IEC A;  1YVM A;  1R5G A;  1WY2 A;  2Q96 A;  4IU6 A;  2BHC A;  4U6E A;  4U71 A;  2BWU A;  2BWT A;  2EVO A;  4U75 A;  4ZWU A;  4FLI A;  3IG4 A;  2V3Y A;  4U73 A;  3S6B A;  5D6F A;  1KP0 A;  2BWV A;  3MAT A;  5E5B A;  4U69 A;  1XGS A;  2MAT A;  4ZWP A;  2BWX A;  3IU7 A;  4FO7 A;  2GG9 A;  5JHU A;  2GG5 A;  1XNZ A;  2GG2 A;  3CB6 A;  4HXX A;  4IKT A;  4PV4 A;  4U1B A;  5FCH A;  3FMR A;  1C21 A;  4RGZ 1;  3TAV A;  5CE6 A;  1N51 A;  1BOA A;  4FUK A;  2Q92 A;  1MAT A;  2V6C A;  2NQ7 A;  1B59 A;  1KQ9 A;  4IKS A;  1QXY A;  4U6J A;  1WN1 A;  2G6P A;  4IDY A;  4IPA A;  2GZ5 A;  2P98 A;  1JAW A;  3MR1 A;  3L7G A;  2BH3 A;  4FO8 A;  4EGE A;  2GU4 A;  4U6Z A;  1M35 A;  4U6W A;  2BB7 A;  1YW9 A;  2V3X A;  1QZY A;  4U70 A;  4U76 A;  3PKE A;  2B3K A;  1XGO A;  4RZZ A;  1Y1N A;  1WL9 A;  1XGM A;  1QXZ A;  3PKD A;  1C24 A;  2GU6 A;  5CDE A;  3FM3 A;  2GG3 A;  3D27 A;  2EVM A;  3IU9 A;  5CDL A;  2BWW A;  2ZSG A;  2GG8 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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