2GG0A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
262
structure length
262
Chain Sequence
ISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 84
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg0A00
2OKNA 3CB5A 1YW8A 2NQ7A 3D27A 1KP0A 2BHCA 4IECA 4EGEA 3IU7A 1YVMA 2BN7A 1W2MA 4PNCA 4PV4A 4RZYA 1C22A 5JI6A 4U6JA 5FCHA 4FLKA 4RGZ1 1WBQA 2P99A 3FMQA 2GA2A 4OOKA 4A6WA 2EVMA 2Q92A 2GG9A 2OAZA 1XGNA 3BIQA 4S00A 1M35A 4U1BA 1JAWA 1YW7A 5CDVA 2BWTA 2EA4A 4U76A 4B28A 3IG4A 2V3ZA 3S6BA 4FO8A 5D6FA 1C23A 1O0XA 2BHDA 2NQ6A 1Y1NA 2B3HA 4IKSA 1KQ0A 4ZNGA 2GZ5A 3Q6DA 4R60A 2Q96A 4HXXA 3PKBA 3MR1A 5CNXA 5CLSA 1KQ9A 2ADUA 2GG0A 1B6AA 5CIKA 2BH3A 1BOAA 2G6PA 2GGCA 3PKAA 3PKEA 4FLJA 2Q8KA 3TB5A 2GG8A 2MATA 4QR8A 4FLLA 1WN1A 3IU9A 2BHAA 2BHBA 3FMRA 4ZWOA 2EVCA 1PV9A 2IW2A 5E5BA 5CDLA 1WLRA 4MATA 1C24A 1XGOA 2BWUA 3MX6A 4U73A 2BB7A 2GU5A 2HOWA 2V6CA 2GG7A 4ZWPA 2BWWA 4U69A 1WL6A 2Q95A 1R5GA 1WY2A 5FCFA 3IU8A 5JFRA 4S2RP 2EVOA 4IF7A 2EA2A 4U6EA 2BWSA 4IKTA 2GU6A 2V3XA 2GU7A 5JHUA 3FM3A 3RVAA 3TAVA 2GU4A 1R58A 4JUQA 4A6VA 4FKCA 3RORA 2BWYA 3CB6A 1CHMA 2BWVA 3L24A 4S2TP 2Q93A 4FO7A 4U6WA 2ZSGA 4IDYA 4ZWUA 4U6ZA 2BWXA 2GG2A 2B3LA 1XNZA 1QXYA 1YW9A 5CE6A 2V3YA 1R5HA 1N51A 2DFIA 4RZZA 4KM3A 2B3KA 2GG5A 1W7VA 3PKDA 4FUKA 1WKMA 1MATA 1XGSA 2P98A 3CTZA 4IPAA 2P9AA 4S01A 4U6CA 5D6EA 1XGMA 3BIPA 1A16A 1YJ3A 2GGBA 1B59A 4U71A 1C27A 4IU6A 3BITA 5CDEA 4FLIA 4IKUA 1C21A 2Q94A 3MATA 1QXWA 1QZYA 2GTXA 2GG3A 4U75A 3PKCA 3L7GA 4Z7MA 1BN5A 1QXZA 4U70A 4IKRA 1WL9A
chains in the Genus database with same CATH superfamily
2OKNA 3CB5A 1YW8A 2NQ7A 3D27A 1KP0A 2BHCA 4IECA 4EGEA 3IU7A 1YVMA 2BN7A 1W2MA 4PNCA 4PV4A 4RZYA 1C22A 5JI6A 4U6JA 5FCHA 4FLKA 4RGZ1 1WBQA 2P99A 3FMQA 2GA2A 4OOKA 4A6WA 2EVMA 2Q92A 2GG9A 2OAZA 1XGNA 3BIQA 4S00A 1M35A 4U1BA 1JAWA 1YW7A 5CDVA 2BWTA 2EA4A 4U76A 4B28A 3IG4A 2V3ZA 3S6BA 4FO8A 5D6FA 1C23A 1O0XA 2BHDA 2NQ6A 1Y1NA 2B3HA 4IKSA 1KQ0A 4ZNGA 2GZ5A 3Q6DA 4R60A 2Q96A 4HXXA 3PKBA 3MR1A 5CNXA 5CLSA 1KQ9A 2ADUA 2GG0A 1B6AA 5CIKA 2BH3A 1BOAA 2G6PA 2GGCA 3PKAA 3PKEA 4FLJA 2Q8KA 3TB5A 2GG8A 2MATA 4QR8A 4FLLA 1WN1A 3IU9A 2BHAA 2BHBA 3FMRA 4ZWOA 2EVCA 1PV9A 2IW2A 5E5BA 5CDLA 1WLRA 4MATA 1C24A 1XGOA 2BWUA 3MX6A 4U73A 2BB7A 2GU5A 2HOWA 2V6CA 2GG7A 4ZWPA 2BWWA 4U69A 1WL6A 2Q95A 1R5GA 1WY2A 5FCFA 3IU8A 5JFRA 4S2RP 2EVOA 4IF7A 2EA2A 4U6EA 2BWSA 4IKTA 2GU6A 2V3XA 2GU7A 5JHUA 3FM3A 3RVAA 3TAVA 2GU4A 1R58A 4JUQA 4A6VA 4FKCA 3RORA 2BWYA 3CB6A 1CHMA 2BWVA 3L24A 4S2TP 2Q93A 4FO7A 4U6WA 2ZSGA 4IDYA 4ZWUA 4U6ZA 2BWXA 2GG2A 2B3LA 1XNZA 1QXYA 1YW9A 5CE6A 2V3YA 1R5HA 1N51A 2DFIA 4RZZA 4KM3A 2B3KA 2GG5A 1W7VA 3PKDA 4FUKA 1WKMA 1MATA 1XGSA 2P98A 3CTZA 4IPAA 2P9AA 4S01A 4U6CA 5D6EA 1XGMA 3BIPA 1A16A 1YJ3A 2GGBA 1B59A 4U71A 1C27A 4IU6A 3BITA 5CDEA 4FLIA 4IKUA 1C21A 2Q94A 3MATA 1QXWA 1QZYA 2GTXA 2GG3A 4U75A 3PKCA 3L7GA 4Z7MA 1BN5A 1QXZA 4U70A 4IKRA 1WL9A
chains in the Genus database with same CATH topology
2OKNA 3CB5A 1YW8A 2NQ7A 3D27A 1KP0A 2BHCA 4IECA 4EGEA 3IU7A 1YVMA 2BN7A 1W2MA 4PNCA 4PV4A 4RZYA 1C22A 5JI6A 4U6JA 5FCHA 4FLKA 4RGZ1 1WBQA 2P99A 3FMQA 2GA2A 4OOKA 4A6WA 2EVMA 2Q92A 2GG9A 2OAZA 1XGNA 3BIQA 4S00A 1M35A 4U1BA 1JAWA 1YW7A 5CDVA 2BWTA 2EA4A 4U76A 4B28A 3IG4A 2V3ZA 3S6BA 4FO8A 5D6FA 1C23A 1O0XA 2BHDA 2NQ6A 1Y1NA 2B3HA 4IKSA 1KQ0A 4ZNGA 2GZ5A 3Q6DA 4R60A 2Q96A 4HXXA 3PKBA 3MR1A 5CNXA 5CLSA 1KQ9A 2ADUA 2GG0A 1B6AA 5CIKA 2BH3A 1BOAA 2G6PA 2GGCA 3PKAA 3PKEA 4FLJA 2Q8KA 3TB5A 2GG8A 2MATA 4QR8A 4FLLA 1WN1A 3IU9A 2BHAA 2BHBA 3FMRA 4ZWOA 2EVCA 1PV9A 2IW2A 5E5BA 5CDLA 1WLRA 4MATA 1C24A 1XGOA 2BWUA 3MX6A 4U73A 2BB7A 2GU5A 2HOWA 2V6CA 2GG7A 4ZWPA 2BWWA 4U69A 1WL6A 2Q95A 1R5GA 1WY2A 5FCFA 3IU8A 5JFRA 4S2RP 2EVOA 4IF7A 2EA2A 4U6EA 2BWSA 4IKTA 2GU6A 2V3XA 2GU7A 5JHUA 3FM3A 3RVAA 3TAVA 2GU4A 1R58A 4JUQA 4A6VA 4FKCA 3RORA 2BWYA 3CB6A 1CHMA 2BWVA 3L24A 4S2TP 2Q93A 4FO7A 4U6WA 2ZSGA 4IDYA 4ZWUA 4U6ZA 2BWXA 2GG2A 2B3LA 1XNZA 1QXYA 1YW9A 5CE6A 2V3YA 1R5HA 1N51A 2DFIA 4RZZA 4KM3A 2B3KA 2GG5A 1W7VA 3PKDA 4FUKA 1WKMA 1MATA 1XGSA 2P98A 3CTZA 4IPAA 2P9AA 4S01A 4U6CA 5D6EA 1XGMA 3BIPA 1A16A 1YJ3A 2GGBA 1B59A 4U71A 1C27A 4IU6A 3BITA 5CDEA 4FLIA 4IKUA 1C21A 2Q94A 3MATA 1QXWA 1QZYA 2GTXA 2GG3A 4U75A 3PKCA 3L7GA 4Z7MA 1BN5A 1QXZA 4U70A 4IKRA 1WL9A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2OKN A;  3CB5 A;  1YW8 A;  2NQ7 A;  3D27 A;  1KP0 A;  2BHC A;  4IEC A;  4EGE A;  3IU7 A;  1YVM A;  2BN7 A;  1W2M A;  4PNC A;  4PV4 A;  4RZY A;  1C22 A;  5JI6 A;  4U6J A;  5FCH A;  4FLK A;  4RGZ 1;  1WBQ A;  2P99 A;  3FMQ A;  2GA2 A;  4OOK A;  4A6W A;  2EVM A;  2Q92 A;  2GG9 A;  2OAZ A;  1XGN A;  3BIQ A;  4S00 A;  1M35 A;  4U1B A;  1JAW A;  1YW7 A;  5CDV A;  2BWT A;  2EA4 A;  4U76 A;  4B28 A;  3IG4 A;  2V3Z A;  3S6B A;  4FO8 A;  5D6F A;  1C23 A;  1O0X A;  2BHD A;  2NQ6 A;  1Y1N A;  2B3H A;  4IKS A;  1KQ0 A;  4ZNG A;  2GZ5 A;  3Q6D A;  4R60 A;  2Q96 A;  4HXX A;  3PKB A;  3MR1 A;  5CNX A;  5CLS A;  1KQ9 A;  2ADU A;  2GG0 A;  1B6A A;  5CIK A;  2BH3 A;  1BOA A;  2G6P A;  2GGC A;  3PKA A;  3PKE A;  4FLJ A;  2Q8K A;  3TB5 A;  2GG8 A;  2MAT A;  4QR8 A;  4FLL A;  1WN1 A;  3IU9 A;  2BHA A;  2BHB A;  3FMR A;  4ZWO A;  2EVC A;  1PV9 A;  2IW2 A;  5E5B A;  5CDL A;  1WLR A;  4MAT A;  1C24 A;  1XGO A;  2BWU A;  3MX6 A;  4U73 A;  2BB7 A;  2GU5 A;  2HOW A;  2V6C A;  2GG7 A;  4ZWP A;  2BWW A;  4U69 A;  1WL6 A;  2Q95 A;  1R5G A;  1WY2 A;  5FCF A;  3IU8 A;  5JFR A;  4S2R P;  2EVO A;  4IF7 A;  2EA2 A;  4U6E A;  2BWS A;  4IKT A;  2GU6 A;  2V3X A;  2GU7 A;  5JHU A;  3FM3 A;  3RVA A;  3TAV A;  2GU4 A;  1R58 A;  4JUQ A;  4A6V A;  4FKC A;  3ROR A;  2BWY A;  3CB6 A;  1CHM A;  2BWV A;  3L24 A;  4S2T P;  2Q93 A;  4FO7 A;  4U6W A;  2ZSG A;  4IDY A;  4ZWU A;  4U6Z A;  2BWX A;  2GG2 A;  2B3L A;  1XNZ A;  1QXY A;  1YW9 A;  5CE6 A;  2V3Y A;  1R5H A;  1N51 A;  2DFI A;  4RZZ A;  4KM3 A;  2B3K A;  2GG5 A;  1W7V A;  3PKD A;  4FUK A;  1WKM A;  1MAT A;  1XGS A;  2P98 A;  3CTZ A;  4IPA A;  2P9A A;  4S01 A;  4U6C A;  5D6E A;  1XGM A;  3BIP A;  1A16 A;  1YJ3 A;  2GGB A;  1B59 A;  4U71 A;  1C27 A;  4IU6 A;  3BIT A;  5CDE A;  4FLI A;  4IKU A;  1C21 A;  2Q94 A;  3MAT A;  1QXW A;  1QZY A;  2GTX A;  2GG3 A;  4U75 A;  3PKC A;  3L7G A;  4Z7M A;  1BN5 A;  1QXZ A;  4U70 A;  4IKR A;  1WL9 A; 
#chains in the Genus database with same CATH topology
 2OKN A;  3CB5 A;  1YW8 A;  2NQ7 A;  3D27 A;  1KP0 A;  2BHC A;  4IEC A;  4EGE A;  3IU7 A;  1YVM A;  2BN7 A;  1W2M A;  4PNC A;  4PV4 A;  4RZY A;  1C22 A;  5JI6 A;  4U6J A;  5FCH A;  4FLK A;  4RGZ 1;  1WBQ A;  2P99 A;  3FMQ A;  2GA2 A;  4OOK A;  4A6W A;  2EVM A;  2Q92 A;  2GG9 A;  2OAZ A;  1XGN A;  3BIQ A;  4S00 A;  1M35 A;  4U1B A;  1JAW A;  1YW7 A;  5CDV A;  2BWT A;  2EA4 A;  4U76 A;  4B28 A;  3IG4 A;  2V3Z A;  3S6B A;  4FO8 A;  5D6F A;  1C23 A;  1O0X A;  2BHD A;  2NQ6 A;  1Y1N A;  2B3H A;  4IKS A;  1KQ0 A;  4ZNG A;  2GZ5 A;  3Q6D A;  4R60 A;  2Q96 A;  4HXX A;  3PKB A;  3MR1 A;  5CNX A;  5CLS A;  1KQ9 A;  2ADU A;  2GG0 A;  1B6A A;  5CIK A;  2BH3 A;  1BOA A;  2G6P A;  2GGC A;  3PKA A;  3PKE A;  4FLJ A;  2Q8K A;  3TB5 A;  2GG8 A;  2MAT A;  4QR8 A;  4FLL A;  1WN1 A;  3IU9 A;  2BHA A;  2BHB A;  3FMR A;  4ZWO A;  2EVC A;  1PV9 A;  2IW2 A;  5E5B A;  5CDL A;  1WLR A;  4MAT A;  1C24 A;  1XGO A;  2BWU A;  3MX6 A;  4U73 A;  2BB7 A;  2GU5 A;  2HOW A;  2V6C A;  2GG7 A;  4ZWP A;  2BWW A;  4U69 A;  1WL6 A;  2Q95 A;  1R5G A;  1WY2 A;  5FCF A;  3IU8 A;  5JFR A;  4S2R P;  2EVO A;  4IF7 A;  2EA2 A;  4U6E A;  2BWS A;  4IKT A;  2GU6 A;  2V3X A;  2GU7 A;  5JHU A;  3FM3 A;  3RVA A;  3TAV A;  2GU4 A;  1R58 A;  4JUQ A;  4A6V A;  4FKC A;  3ROR A;  2BWY A;  3CB6 A;  1CHM A;  2BWV A;  3L24 A;  4S2T P;  2Q93 A;  4FO7 A;  4U6W A;  2ZSG A;  4IDY A;  4ZWU A;  4U6Z A;  2BWX A;  2GG2 A;  2B3L A;  1XNZ A;  1QXY A;  1YW9 A;  5CE6 A;  2V3Y A;  1R5H A;  1N51 A;  2DFI A;  4RZZ A;  4KM3 A;  2B3K A;  2GG5 A;  1W7V A;  3PKD A;  4FUK A;  1WKM A;  1MAT A;  1XGS A;  2P98 A;  3CTZ A;  4IPA A;  2P9A A;  4S01 A;  4U6C A;  5D6E A;  1XGM A;  3BIP A;  1A16 A;  1YJ3 A;  2GGB A;  1B59 A;  4U71 A;  1C27 A;  4IU6 A;  3BIT A;  5CDE A;  4FLI A;  4IKU A;  1C21 A;  2Q94 A;  3MAT A;  1QXW A;  1QZY A;  2GTX A;  2GG3 A;  4U75 A;  3PKC A;  3L7G A;  4Z7M A;  1BN5 A;  1QXZ A;  4U70 A;  4IKR A;  1WL9 A; 
#chains in the Genus database with same CATH homology
 2OKN A;  3CB5 A;  1YW8 A;  2NQ7 A;  3D27 A;  1KP0 A;  2BHC A;  4IEC A;  4EGE A;  3IU7 A;  1YVM A;  2BN7 A;  1W2M A;  4PNC A;  4PV4 A;  4RZY A;  1C22 A;  5JI6 A;  4U6J A;  5FCH A;  4FLK A;  4RGZ 1;  1WBQ A;  2P99 A;  3FMQ A;  2GA2 A;  4OOK A;  4A6W A;  2EVM A;  2Q92 A;  2GG9 A;  2OAZ A;  1XGN A;  3BIQ A;  4S00 A;  1M35 A;  4U1B A;  1JAW A;  1YW7 A;  5CDV A;  2BWT A;  2EA4 A;  4U76 A;  4B28 A;  3IG4 A;  2V3Z A;  3S6B A;  4FO8 A;  5D6F A;  1C23 A;  1O0X A;  2BHD A;  2NQ6 A;  1Y1N A;  2B3H A;  4IKS A;  1KQ0 A;  4ZNG A;  2GZ5 A;  3Q6D A;  4R60 A;  2Q96 A;  4HXX A;  3PKB A;  3MR1 A;  5CNX A;  5CLS A;  1KQ9 A;  2ADU A;  2GG0 A;  1B6A A;  5CIK A;  2BH3 A;  1BOA A;  2G6P A;  2GGC A;  3PKA A;  3PKE A;  4FLJ A;  2Q8K A;  3TB5 A;  2GG8 A;  2MAT A;  4QR8 A;  4FLL A;  1WN1 A;  3IU9 A;  2BHA A;  2BHB A;  3FMR A;  4ZWO A;  2EVC A;  1PV9 A;  2IW2 A;  5E5B A;  5CDL A;  1WLR A;  4MAT A;  1C24 A;  1XGO A;  2BWU A;  3MX6 A;  4U73 A;  2BB7 A;  2GU5 A;  2HOW A;  2V6C A;  2GG7 A;  4ZWP A;  2BWW A;  4U69 A;  1WL6 A;  2Q95 A;  1R5G A;  1WY2 A;  5FCF A;  3IU8 A;  5JFR A;  4S2R P;  2EVO A;  4IF7 A;  2EA2 A;  4U6E A;  2BWS A;  4IKT A;  2GU6 A;  2V3X A;  2GU7 A;  5JHU A;  3FM3 A;  3RVA A;  3TAV A;  2GU4 A;  1R58 A;  4JUQ A;  4A6V A;  4FKC A;  3ROR A;  2BWY A;  3CB6 A;  1CHM A;  2BWV A;  3L24 A;  4S2T P;  2Q93 A;  4FO7 A;  4U6W A;  2ZSG A;  4IDY A;  4ZWU A;  4U6Z A;  2BWX A;  2GG2 A;  2B3L A;  1XNZ A;  1QXY A;  1YW9 A;  5CE6 A;  2V3Y A;  1R5H A;  1N51 A;  2DFI A;  4RZZ A;  4KM3 A;  2B3K A;  2GG5 A;  1W7V A;  3PKD A;  4FUK A;  1WKM A;  1MAT A;  1XGS A;  2P98 A;  3CTZ A;  4IPA A;  2P9A A;  4S01 A;  4U6C A;  5D6E A;  1XGM A;  3BIP A;  1A16 A;  1YJ3 A;  2GGB A;  1B59 A;  4U71 A;  1C27 A;  4IU6 A;  3BIT A;  5CDE A;  4FLI A;  4IKU A;  1C21 A;  2Q94 A;  3MAT A;  1QXW A;  1QZY A;  2GTX A;  2GG3 A;  4U75 A;  3PKC A;  3L7G A;  4Z7M A;  1BN5 A;  1QXZ A;  4U70 A;  4IKR A;  1WL9 A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite