2GG2A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 84
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg2A00
4OOKA 3IU8A 1XNZA 3CB5A 3BIPA 3MR1A 2IW2A 2NQ7A 1XGNA 1C27A 4FO7A 1R58A 2Q95A 5CNXA 1KQ9A 5CLSA 1YW8A 4PV4A 3D27A 2B3LA 3CTZA 3PKBA 3PKAA 3IG4A 3Q6DA 4RZYA 3IU9A 2BWWA 2HOWA 4KM3A 2BHAA 4PNCA 2OKNA 5E5BA 4U6CA 1A16A 1KQ0A 1N51A 4S01A 2GU4A 1QXWA 5JHUA 4HXXA 5CDEA 3PKCA 1O0XA 5CDVA 2GZ5A 2GG8A 2BWYA 1W7VA 5FCFA 1WBQA 1YJ3A 4U6JA 2BWTA 4FUKA 2GG2A 1R5HA 1YW7A 1W2MA 2Q94A 2G6PA 1YW9A 2GG3A 2BN7A 3BITA 4U71A 4FLIA 3TAVA 2P9AA 1BN5A 3FM3A 4U6WA 2V3ZA 1MATA 5CE6A 2BWUA 3L24A 4B28A 5JI6A 1M35A 2OAZA 4ZWUA 2BHCA 4ZNGA 4EGEA 3PKEA 2V3YA 1YVMA 3RVAA 1C21A 2GGBA 2GGCA 2GU7A 4A6WA 2EVMA 2GG5A 2B3KA 4JUQA 4ZWPA 4U70A 2BB7A 2GG0A 4U76A 1WL6A 4IKSA 1C22A 4MATA 4IU6A 1KP0A 2GG7A 3PKDA 3MATA 2GU5A 2ZSGA 4RZZA 3L7GA 4FLLA 4R60A 2V3XA 3CB6A 5JFRA 1WN1A 4IDYA 3IU7A 1WL9A 2EVCA 2P99A 4FO8A 1BOAA 4QR8A 1QXZA 4U6EA 1QXYA 4Z7MA 3FMQA 2BWVA 2GTXA 5CIKA 2MATA 4IKUA 2DFIA 1JAWA 4A6VA 2Q92A 2GG9A 1C24A 5D6EA 4U75A 4S00A 4FLKA 2BH3A 3TB5A 2BWXA 1WLRA 3FMRA 1XGSA 4S2TP 3BIQA 4U1BA 2Q96A 2P98A 3S6BA 4IECA 2EA2A 2BWSA 4S2RP 1C23A 2BHBA 4IPAA 3RORA 1R5GA 1B6AA 2BHDA 2EA4A 1QZYA 1XGMA 2V6CA 4RGZ1 2ADUA 1Y1NA 2NQ6A 4U73A 4U69A 2GA2A 5D6FA 4ZWOA 2EVOA 1CHMA 4FKCA 2Q93A 2GU6A 3MX6A 5CDLA 4IKRA 1WY2A 4IF7A 1XGOA 2B3HA 4IKTA 1B59A 1WKMA 5FCHA 1PV9A 4U6ZA 4FLJA 2Q8KA
chains in the Genus database with same CATH superfamily
4OOKA 3IU8A 1XNZA 3CB5A 3BIPA 3MR1A 2IW2A 2NQ7A 1XGNA 1C27A 4FO7A 1R58A 2Q95A 5CNXA 1KQ9A 5CLSA 1YW8A 4PV4A 3D27A 2B3LA 3CTZA 3PKBA 3PKAA 3IG4A 3Q6DA 4RZYA 3IU9A 2BWWA 2HOWA 4KM3A 2BHAA 4PNCA 2OKNA 5E5BA 4U6CA 1A16A 1KQ0A 1N51A 4S01A 2GU4A 1QXWA 5JHUA 4HXXA 5CDEA 3PKCA 1O0XA 5CDVA 2GZ5A 2GG8A 2BWYA 1W7VA 5FCFA 1WBQA 1YJ3A 4U6JA 2BWTA 4FUKA 2GG2A 1R5HA 1YW7A 1W2MA 2Q94A 2G6PA 1YW9A 2GG3A 2BN7A 3BITA 4U71A 4FLIA 3TAVA 2P9AA 1BN5A 3FM3A 4U6WA 2V3ZA 1MATA 5CE6A 2BWUA 3L24A 4B28A 5JI6A 1M35A 2OAZA 4ZWUA 2BHCA 4ZNGA 4EGEA 3PKEA 2V3YA 1YVMA 3RVAA 1C21A 2GGBA 2GGCA 2GU7A 4A6WA 2EVMA 2GG5A 2B3KA 4JUQA 4ZWPA 4U70A 2BB7A 2GG0A 4U76A 1WL6A 4IKSA 1C22A 4MATA 4IU6A 1KP0A 2GG7A 3PKDA 3MATA 2GU5A 2ZSGA 4RZZA 3L7GA 4FLLA 4R60A 2V3XA 3CB6A 5JFRA 1WN1A 4IDYA 3IU7A 1WL9A 2EVCA 2P99A 4FO8A 1BOAA 4QR8A 1QXZA 4U6EA 1QXYA 4Z7MA 3FMQA 2BWVA 2GTXA 5CIKA 2MATA 4IKUA 2DFIA 1JAWA 4A6VA 2Q92A 2GG9A 1C24A 5D6EA 4U75A 4S00A 4FLKA 2BH3A 3TB5A 2BWXA 1WLRA 3FMRA 1XGSA 4S2TP 3BIQA 4U1BA 2Q96A 2P98A 3S6BA 4IECA 2EA2A 2BWSA 4S2RP 1C23A 2BHBA 4IPAA 3RORA 1R5GA 1B6AA 2BHDA 2EA4A 1QZYA 1XGMA 2V6CA 4RGZ1 2ADUA 1Y1NA 2NQ6A 4U73A 4U69A 2GA2A 5D6FA 4ZWOA 2EVOA 1CHMA 4FKCA 2Q93A 2GU6A 3MX6A 5CDLA 4IKRA 1WY2A 4IF7A 1XGOA 2B3HA 4IKTA 1B59A 1WKMA 5FCHA 1PV9A 4U6ZA 4FLJA 2Q8KA
chains in the Genus database with same CATH topology
4OOKA 3IU8A 1XNZA 3CB5A 3BIPA 3MR1A 2IW2A 2NQ7A 1XGNA 1C27A 4FO7A 1R58A 2Q95A 5CNXA 1KQ9A 5CLSA 1YW8A 4PV4A 3D27A 2B3LA 3CTZA 3PKBA 3PKAA 3IG4A 3Q6DA 4RZYA 3IU9A 2BWWA 2HOWA 4KM3A 2BHAA 4PNCA 2OKNA 5E5BA 4U6CA 1A16A 1KQ0A 1N51A 4S01A 2GU4A 1QXWA 5JHUA 4HXXA 5CDEA 3PKCA 1O0XA 5CDVA 2GZ5A 2GG8A 2BWYA 1W7VA 5FCFA 1WBQA 1YJ3A 4U6JA 2BWTA 4FUKA 2GG2A 1R5HA 1YW7A 1W2MA 2Q94A 2G6PA 1YW9A 2GG3A 2BN7A 3BITA 4U71A 4FLIA 3TAVA 2P9AA 1BN5A 3FM3A 4U6WA 2V3ZA 1MATA 5CE6A 2BWUA 3L24A 4B28A 5JI6A 1M35A 2OAZA 4ZWUA 2BHCA 4ZNGA 4EGEA 3PKEA 2V3YA 1YVMA 3RVAA 1C21A 2GGBA 2GGCA 2GU7A 4A6WA 2EVMA 2GG5A 2B3KA 4JUQA 4ZWPA 4U70A 2BB7A 2GG0A 4U76A 1WL6A 4IKSA 1C22A 4MATA 4IU6A 1KP0A 2GG7A 3PKDA 3MATA 2GU5A 2ZSGA 4RZZA 3L7GA 4FLLA 4R60A 2V3XA 3CB6A 5JFRA 1WN1A 4IDYA 3IU7A 1WL9A 2EVCA 2P99A 4FO8A 1BOAA 4QR8A 1QXZA 4U6EA 1QXYA 4Z7MA 3FMQA 2BWVA 2GTXA 5CIKA 2MATA 4IKUA 2DFIA 1JAWA 4A6VA 2Q92A 2GG9A 1C24A 5D6EA 4U75A 4S00A 4FLKA 2BH3A 3TB5A 2BWXA 1WLRA 3FMRA 1XGSA 4S2TP 3BIQA 4U1BA 2Q96A 2P98A 3S6BA 4IECA 2EA2A 2BWSA 4S2RP 1C23A 2BHBA 4IPAA 3RORA 1R5GA 1B6AA 2BHDA 2EA4A 1QZYA 1XGMA 2V6CA 4RGZ1 2ADUA 1Y1NA 2NQ6A 4U73A 4U69A 2GA2A 5D6FA 4ZWOA 2EVOA 1CHMA 4FKCA 2Q93A 2GU6A 3MX6A 5CDLA 4IKRA 1WY2A 4IF7A 1XGOA 2B3HA 4IKTA 1B59A 1WKMA 5FCHA 1PV9A 4U6ZA 4FLJA 2Q8KA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OOK A;  3IU8 A;  1XNZ A;  3CB5 A;  3BIP A;  3MR1 A;  2IW2 A;  2NQ7 A;  1XGN A;  1C27 A;  4FO7 A;  1R58 A;  2Q95 A;  5CNX A;  1KQ9 A;  5CLS A;  1YW8 A;  4PV4 A;  3D27 A;  2B3L A;  3CTZ A;  3PKB A;  3PKA A;  3IG4 A;  3Q6D A;  4RZY A;  3IU9 A;  2BWW A;  2HOW A;  4KM3 A;  2BHA A;  4PNC A;  2OKN A;  5E5B A;  4U6C A;  1A16 A;  1KQ0 A;  1N51 A;  4S01 A;  2GU4 A;  1QXW A;  5JHU A;  4HXX A;  5CDE A;  3PKC A;  1O0X A;  5CDV A;  2GZ5 A;  2GG8 A;  2BWY A;  1W7V A;  5FCF A;  1WBQ A;  1YJ3 A;  4U6J A;  2BWT A;  4FUK A;  2GG2 A;  1R5H A;  1YW7 A;  1W2M A;  2Q94 A;  2G6P A;  1YW9 A;  2GG3 A;  2BN7 A;  3BIT A;  4U71 A;  4FLI A;  3TAV A;  2P9A A;  1BN5 A;  3FM3 A;  4U6W A;  2V3Z A;  1MAT A;  5CE6 A;  2BWU A;  3L24 A;  4B28 A;  5JI6 A;  1M35 A;  2OAZ A;  4ZWU A;  2BHC A;  4ZNG A;  4EGE A;  3PKE A;  2V3Y A;  1YVM A;  3RVA A;  1C21 A;  2GGB A;  2GGC A;  2GU7 A;  4A6W A;  2EVM A;  2GG5 A;  2B3K A;  4JUQ A;  4ZWP A;  4U70 A;  2BB7 A;  2GG0 A;  4U76 A;  1WL6 A;  4IKS A;  1C22 A;  4MAT A;  4IU6 A;  1KP0 A;  2GG7 A;  3PKD A;  3MAT A;  2GU5 A;  2ZSG A;  4RZZ A;  3L7G A;  4FLL A;  4R60 A;  2V3X A;  3CB6 A;  5JFR A;  1WN1 A;  4IDY A;  3IU7 A;  1WL9 A;  2EVC A;  2P99 A;  4FO8 A;  1BOA A;  4QR8 A;  1QXZ A;  4U6E A;  1QXY A;  4Z7M A;  3FMQ A;  2BWV A;  2GTX A;  5CIK A;  2MAT A;  4IKU A;  2DFI A;  1JAW A;  4A6V A;  2Q92 A;  2GG9 A;  1C24 A;  5D6E A;  4U75 A;  4S00 A;  4FLK A;  2BH3 A;  3TB5 A;  2BWX A;  1WLR A;  3FMR A;  1XGS A;  4S2T P;  3BIQ A;  4U1B A;  2Q96 A;  2P98 A;  3S6B A;  4IEC A;  2EA2 A;  2BWS A;  4S2R P;  1C23 A;  2BHB A;  4IPA A;  3ROR A;  1R5G A;  1B6A A;  2BHD A;  2EA4 A;  1QZY A;  1XGM A;  2V6C A;  4RGZ 1;  2ADU A;  1Y1N A;  2NQ6 A;  4U73 A;  4U69 A;  2GA2 A;  5D6F A;  4ZWO A;  2EVO A;  1CHM A;  4FKC A;  2Q93 A;  2GU6 A;  3MX6 A;  5CDL A;  4IKR A;  1WY2 A;  4IF7 A;  1XGO A;  2B3H A;  4IKT A;  1B59 A;  1WKM A;  5FCH A;  1PV9 A;  4U6Z A;  4FLJ A;  2Q8K A; 
#chains in the Genus database with same CATH topology
 4OOK A;  3IU8 A;  1XNZ A;  3CB5 A;  3BIP A;  3MR1 A;  2IW2 A;  2NQ7 A;  1XGN A;  1C27 A;  4FO7 A;  1R58 A;  2Q95 A;  5CNX A;  1KQ9 A;  5CLS A;  1YW8 A;  4PV4 A;  3D27 A;  2B3L A;  3CTZ A;  3PKB A;  3PKA A;  3IG4 A;  3Q6D A;  4RZY A;  3IU9 A;  2BWW A;  2HOW A;  4KM3 A;  2BHA A;  4PNC A;  2OKN A;  5E5B A;  4U6C A;  1A16 A;  1KQ0 A;  1N51 A;  4S01 A;  2GU4 A;  1QXW A;  5JHU A;  4HXX A;  5CDE A;  3PKC A;  1O0X A;  5CDV A;  2GZ5 A;  2GG8 A;  2BWY A;  1W7V A;  5FCF A;  1WBQ A;  1YJ3 A;  4U6J A;  2BWT A;  4FUK A;  2GG2 A;  1R5H A;  1YW7 A;  1W2M A;  2Q94 A;  2G6P A;  1YW9 A;  2GG3 A;  2BN7 A;  3BIT A;  4U71 A;  4FLI A;  3TAV A;  2P9A A;  1BN5 A;  3FM3 A;  4U6W A;  2V3Z A;  1MAT A;  5CE6 A;  2BWU A;  3L24 A;  4B28 A;  5JI6 A;  1M35 A;  2OAZ A;  4ZWU A;  2BHC A;  4ZNG A;  4EGE A;  3PKE A;  2V3Y A;  1YVM A;  3RVA A;  1C21 A;  2GGB A;  2GGC A;  2GU7 A;  4A6W A;  2EVM A;  2GG5 A;  2B3K A;  4JUQ A;  4ZWP A;  4U70 A;  2BB7 A;  2GG0 A;  4U76 A;  1WL6 A;  4IKS A;  1C22 A;  4MAT A;  4IU6 A;  1KP0 A;  2GG7 A;  3PKD A;  3MAT A;  2GU5 A;  2ZSG A;  4RZZ A;  3L7G A;  4FLL A;  4R60 A;  2V3X A;  3CB6 A;  5JFR A;  1WN1 A;  4IDY A;  3IU7 A;  1WL9 A;  2EVC A;  2P99 A;  4FO8 A;  1BOA A;  4QR8 A;  1QXZ A;  4U6E A;  1QXY A;  4Z7M A;  3FMQ A;  2BWV A;  2GTX A;  5CIK A;  2MAT A;  4IKU A;  2DFI A;  1JAW A;  4A6V A;  2Q92 A;  2GG9 A;  1C24 A;  5D6E A;  4U75 A;  4S00 A;  4FLK A;  2BH3 A;  3TB5 A;  2BWX A;  1WLR A;  3FMR A;  1XGS A;  4S2T P;  3BIQ A;  4U1B A;  2Q96 A;  2P98 A;  3S6B A;  4IEC A;  2EA2 A;  2BWS A;  4S2R P;  1C23 A;  2BHB A;  4IPA A;  3ROR A;  1R5G A;  1B6A A;  2BHD A;  2EA4 A;  1QZY A;  1XGM A;  2V6C A;  4RGZ 1;  2ADU A;  1Y1N A;  2NQ6 A;  4U73 A;  4U69 A;  2GA2 A;  5D6F A;  4ZWO A;  2EVO A;  1CHM A;  4FKC A;  2Q93 A;  2GU6 A;  3MX6 A;  5CDL A;  4IKR A;  1WY2 A;  4IF7 A;  1XGO A;  2B3H A;  4IKT A;  1B59 A;  1WKM A;  5FCH A;  1PV9 A;  4U6Z A;  4FLJ A;  2Q8K A; 
#chains in the Genus database with same CATH homology
 4OOK A;  3IU8 A;  1XNZ A;  3CB5 A;  3BIP A;  3MR1 A;  2IW2 A;  2NQ7 A;  1XGN A;  1C27 A;  4FO7 A;  1R58 A;  2Q95 A;  5CNX A;  1KQ9 A;  5CLS A;  1YW8 A;  4PV4 A;  3D27 A;  2B3L A;  3CTZ A;  3PKB A;  3PKA A;  3IG4 A;  3Q6D A;  4RZY A;  3IU9 A;  2BWW A;  2HOW A;  4KM3 A;  2BHA A;  4PNC A;  2OKN A;  5E5B A;  4U6C A;  1A16 A;  1KQ0 A;  1N51 A;  4S01 A;  2GU4 A;  1QXW A;  5JHU A;  4HXX A;  5CDE A;  3PKC A;  1O0X A;  5CDV A;  2GZ5 A;  2GG8 A;  2BWY A;  1W7V A;  5FCF A;  1WBQ A;  1YJ3 A;  4U6J A;  2BWT A;  4FUK A;  2GG2 A;  1R5H A;  1YW7 A;  1W2M A;  2Q94 A;  2G6P A;  1YW9 A;  2GG3 A;  2BN7 A;  3BIT A;  4U71 A;  4FLI A;  3TAV A;  2P9A A;  1BN5 A;  3FM3 A;  4U6W A;  2V3Z A;  1MAT A;  5CE6 A;  2BWU A;  3L24 A;  4B28 A;  5JI6 A;  1M35 A;  2OAZ A;  4ZWU A;  2BHC A;  4ZNG A;  4EGE A;  3PKE A;  2V3Y A;  1YVM A;  3RVA A;  1C21 A;  2GGB A;  2GGC A;  2GU7 A;  4A6W A;  2EVM A;  2GG5 A;  2B3K A;  4JUQ A;  4ZWP A;  4U70 A;  2BB7 A;  2GG0 A;  4U76 A;  1WL6 A;  4IKS A;  1C22 A;  4MAT A;  4IU6 A;  1KP0 A;  2GG7 A;  3PKD A;  3MAT A;  2GU5 A;  2ZSG A;  4RZZ A;  3L7G A;  4FLL A;  4R60 A;  2V3X A;  3CB6 A;  5JFR A;  1WN1 A;  4IDY A;  3IU7 A;  1WL9 A;  2EVC A;  2P99 A;  4FO8 A;  1BOA A;  4QR8 A;  1QXZ A;  4U6E A;  1QXY A;  4Z7M A;  3FMQ A;  2BWV A;  2GTX A;  5CIK A;  2MAT A;  4IKU A;  2DFI A;  1JAW A;  4A6V A;  2Q92 A;  2GG9 A;  1C24 A;  5D6E A;  4U75 A;  4S00 A;  4FLK A;  2BH3 A;  3TB5 A;  2BWX A;  1WLR A;  3FMR A;  1XGS A;  4S2T P;  3BIQ A;  4U1B A;  2Q96 A;  2P98 A;  3S6B A;  4IEC A;  2EA2 A;  2BWS A;  4S2R P;  1C23 A;  2BHB A;  4IPA A;  3ROR A;  1R5G A;  1B6A A;  2BHD A;  2EA4 A;  1QZY A;  1XGM A;  2V6C A;  4RGZ 1;  2ADU A;  1Y1N A;  2NQ6 A;  4U73 A;  4U69 A;  2GA2 A;  5D6F A;  4ZWO A;  2EVO A;  1CHM A;  4FKC A;  2Q93 A;  2GU6 A;  3MX6 A;  5CDL A;  4IKR A;  1WY2 A;  4IF7 A;  1XGO A;  2B3H A;  4IKT A;  1B59 A;  1WKM A;  5FCH A;  1PV9 A;  4U6Z A;  4FLJ A;  2Q8K A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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