2GG2A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 84
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg2A00
2GG7A 2OAZA 1YJ3A 1MATA 2GGBA 2Q94A 5D6FA 3PKEA 5FCFA 2EVMA 4U6ZA 5JI6A 2BWTA 2P99A 3D27A 4A6WA 1JAWA 2GG3A 2BWXA 4IU6A 4S2RP 4IECA 3BITA 1XGSA 2DFIA 2Q93A 2GG2A 4A6VA 1C27A 1WKMA 3MATA 1C24A 4U73A 2NQ6A 3TB5A 3RVAA 2B3HA 3IU9A 2BHBA 5D6EA 3BIQA 1C21A 2BN7A 1W7VA 2BH3A 5CNXA 2BB7A 4B28A 3BIPA 2HOWA 5CIKA 2EVCA 1A16A 2GTXA 2EVOA 3RORA 3PKCA 4U71A 2GZ5A 1QXYA 1BOAA 2GA2A 1KQ0A 4FO7A 2BWUA 3S6BA 2V3XA 4S2TP 1N51A 1B59A 2GG5A 2GG9A 1WL6A 3IG4A 3Q6DA 5CDEA 1WLRA 4FLIA 4FLLA 1BN5A 1YW9A 4R60A 5JHUA 2GGCA 2NQ7A 4U70A 2G6PA 3CB5A 4RGZ1 1YVMA 2V3YA 2EA2A 1B6AA 3TAVA 2GG0A 4OOKA 4IKTA 5CDVA 4U6JA 1QXWA 4ZWPA 2V6CA 4U6CA 5CDLA 2BHDA 2P98A 2V3ZA 1O0XA 4U6EA 2EA4A 4Z7MA 2GU7A 4U69A 3FM3A 2IW2A 4EGEA 2BHCA 2BWWA 4S00A 1WN1A 4U6WA 1XNZA 2OKNA 4ZNGA 1KQ9A 4FLKA 1QZYA 5E5BA 2BWVA 2BWSA 2GG8A 3FMQA 3MR1A 4RZZA 1C22A 1CHMA 5JFRA 2BHAA 1R5GA 1YW8A 3CTZA 1YW7A 4ZWOA 4HXXA 1WY2A 2GU4A 4PV4A 4S01A 4FO8A 5FCHA 2GU6A 4FUKA 3CB6A 4IKUA 3PKBA 4JUQA 1WL9A 2Q8KA 3PKDA 5CE6A 2GU5A 2ADUA 4IKSA 1R58A 4MATA 4ZWUA 4PNCA 4IKRA 4FLJA 4U1BA 1R5HA 4U75A 3MX6A 1XGOA 3IU8A 2Q96A 2P9AA 4FKCA 4IPAA 1PV9A 3L24A 1M35A 1WBQA 2MATA 3PKAA 2ZSGA 4U76A 4QR8A 3L7GA 3IU7A 4IF7A 1KP0A 1Y1NA 2B3KA 4RZYA 1QXZA 2BWYA 5CLSA 1XGNA 1XGMA 2B3LA 2Q92A 3FMRA 4KM3A 4IDYA 2Q95A 1W2MA 1C23A
chains in the Genus database with same CATH superfamily
2GG7A 2OAZA 1YJ3A 1MATA 2GGBA 2Q94A 5D6FA 3PKEA 5FCFA 2EVMA 4U6ZA 5JI6A 2BWTA 2P99A 3D27A 4A6WA 1JAWA 2GG3A 2BWXA 4IU6A 4S2RP 4IECA 3BITA 1XGSA 2DFIA 2Q93A 2GG2A 4A6VA 1C27A 1WKMA 3MATA 1C24A 4U73A 2NQ6A 3TB5A 3RVAA 2B3HA 3IU9A 2BHBA 5D6EA 3BIQA 1C21A 2BN7A 1W7VA 2BH3A 5CNXA 2BB7A 4B28A 3BIPA 2HOWA 5CIKA 2EVCA 1A16A 2GTXA 2EVOA 3RORA 3PKCA 4U71A 2GZ5A 1QXYA 1BOAA 2GA2A 1KQ0A 4FO7A 2BWUA 3S6BA 2V3XA 4S2TP 1N51A 1B59A 2GG5A 2GG9A 1WL6A 3IG4A 3Q6DA 5CDEA 1WLRA 4FLIA 4FLLA 1BN5A 1YW9A 4R60A 5JHUA 2GGCA 2NQ7A 4U70A 2G6PA 3CB5A 4RGZ1 1YVMA 2V3YA 2EA2A 1B6AA 3TAVA 2GG0A 4OOKA 4IKTA 5CDVA 4U6JA 1QXWA 4ZWPA 2V6CA 4U6CA 5CDLA 2BHDA 2P98A 2V3ZA 1O0XA 4U6EA 2EA4A 4Z7MA 2GU7A 4U69A 3FM3A 2IW2A 4EGEA 2BHCA 2BWWA 4S00A 1WN1A 4U6WA 1XNZA 2OKNA 4ZNGA 1KQ9A 4FLKA 1QZYA 5E5BA 2BWVA 2BWSA 2GG8A 3FMQA 3MR1A 4RZZA 1C22A 1CHMA 5JFRA 2BHAA 1R5GA 1YW8A 3CTZA 1YW7A 4ZWOA 4HXXA 1WY2A 2GU4A 4PV4A 4S01A 4FO8A 5FCHA 2GU6A 4FUKA 3CB6A 4IKUA 3PKBA 4JUQA 1WL9A 2Q8KA 3PKDA 5CE6A 2GU5A 2ADUA 4IKSA 1R58A 4MATA 4ZWUA 4PNCA 4IKRA 4FLJA 4U1BA 1R5HA 4U75A 3MX6A 1XGOA 3IU8A 2Q96A 2P9AA 4FKCA 4IPAA 1PV9A 3L24A 1M35A 1WBQA 2MATA 3PKAA 2ZSGA 4U76A 4QR8A 3L7GA 3IU7A 4IF7A 1KP0A 1Y1NA 2B3KA 4RZYA 1QXZA 2BWYA 5CLSA 1XGNA 1XGMA 2B3LA 2Q92A 3FMRA 4KM3A 4IDYA 2Q95A 1W2MA 1C23A
chains in the Genus database with same CATH topology
2GG7A 2OAZA 1YJ3A 1MATA 2GGBA 2Q94A 5D6FA 3PKEA 5FCFA 2EVMA 4U6ZA 5JI6A 2BWTA 2P99A 3D27A 4A6WA 1JAWA 2GG3A 2BWXA 4IU6A 4S2RP 4IECA 3BITA 1XGSA 2DFIA 2Q93A 2GG2A 4A6VA 1C27A 1WKMA 3MATA 1C24A 4U73A 2NQ6A 3TB5A 3RVAA 2B3HA 3IU9A 2BHBA 5D6EA 3BIQA 1C21A 2BN7A 1W7VA 2BH3A 5CNXA 2BB7A 4B28A 3BIPA 2HOWA 5CIKA 2EVCA 1A16A 2GTXA 2EVOA 3RORA 3PKCA 4U71A 2GZ5A 1QXYA 1BOAA 2GA2A 1KQ0A 4FO7A 2BWUA 3S6BA 2V3XA 4S2TP 1N51A 1B59A 2GG5A 2GG9A 1WL6A 3IG4A 3Q6DA 5CDEA 1WLRA 4FLIA 4FLLA 1BN5A 1YW9A 4R60A 5JHUA 2GGCA 2NQ7A 4U70A 2G6PA 3CB5A 4RGZ1 1YVMA 2V3YA 2EA2A 1B6AA 3TAVA 2GG0A 4OOKA 4IKTA 5CDVA 4U6JA 1QXWA 4ZWPA 2V6CA 4U6CA 5CDLA 2BHDA 2P98A 2V3ZA 1O0XA 4U6EA 2EA4A 4Z7MA 2GU7A 4U69A 3FM3A 2IW2A 4EGEA 2BHCA 2BWWA 4S00A 1WN1A 4U6WA 1XNZA 2OKNA 4ZNGA 1KQ9A 4FLKA 1QZYA 5E5BA 2BWVA 2BWSA 2GG8A 3FMQA 3MR1A 4RZZA 1C22A 1CHMA 5JFRA 2BHAA 1R5GA 1YW8A 3CTZA 1YW7A 4ZWOA 4HXXA 1WY2A 2GU4A 4PV4A 4S01A 4FO8A 5FCHA 2GU6A 4FUKA 3CB6A 4IKUA 3PKBA 4JUQA 1WL9A 2Q8KA 3PKDA 5CE6A 2GU5A 2ADUA 4IKSA 1R58A 4MATA 4ZWUA 4PNCA 4IKRA 4FLJA 4U1BA 1R5HA 4U75A 3MX6A 1XGOA 3IU8A 2Q96A 2P9AA 4FKCA 4IPAA 1PV9A 3L24A 1M35A 1WBQA 2MATA 3PKAA 2ZSGA 4U76A 4QR8A 3L7GA 3IU7A 4IF7A 1KP0A 1Y1NA 2B3KA 4RZYA 1QXZA 2BWYA 5CLSA 1XGNA 1XGMA 2B3LA 2Q92A 3FMRA 4KM3A 4IDYA 2Q95A 1W2MA 1C23A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GG7 A;  2OAZ A;  1YJ3 A;  1MAT A;  2GGB A;  2Q94 A;  5D6F A;  3PKE A;  5FCF A;  2EVM A;  4U6Z A;  5JI6 A;  2BWT A;  2P99 A;  3D27 A;  4A6W A;  1JAW A;  2GG3 A;  2BWX A;  4IU6 A;  4S2R P;  4IEC A;  3BIT A;  1XGS A;  2DFI A;  2Q93 A;  2GG2 A;  4A6V A;  1C27 A;  1WKM A;  3MAT A;  1C24 A;  4U73 A;  2NQ6 A;  3TB5 A;  3RVA A;  2B3H A;  3IU9 A;  2BHB A;  5D6E A;  3BIQ A;  1C21 A;  2BN7 A;  1W7V A;  2BH3 A;  5CNX A;  2BB7 A;  4B28 A;  3BIP A;  2HOW A;  5CIK A;  2EVC A;  1A16 A;  2GTX A;  2EVO A;  3ROR A;  3PKC A;  4U71 A;  2GZ5 A;  1QXY A;  1BOA A;  2GA2 A;  1KQ0 A;  4FO7 A;  2BWU A;  3S6B A;  2V3X A;  4S2T P;  1N51 A;  1B59 A;  2GG5 A;  2GG9 A;  1WL6 A;  3IG4 A;  3Q6D A;  5CDE A;  1WLR A;  4FLI A;  4FLL A;  1BN5 A;  1YW9 A;  4R60 A;  5JHU A;  2GGC A;  2NQ7 A;  4U70 A;  2G6P A;  3CB5 A;  4RGZ 1;  1YVM A;  2V3Y A;  2EA2 A;  1B6A A;  3TAV A;  2GG0 A;  4OOK A;  4IKT A;  5CDV A;  4U6J A;  1QXW A;  4ZWP A;  2V6C A;  4U6C A;  5CDL A;  2BHD A;  2P98 A;  2V3Z A;  1O0X A;  4U6E A;  2EA4 A;  4Z7M A;  2GU7 A;  4U69 A;  3FM3 A;  2IW2 A;  4EGE A;  2BHC A;  2BWW A;  4S00 A;  1WN1 A;  4U6W A;  1XNZ A;  2OKN A;  4ZNG A;  1KQ9 A;  4FLK A;  1QZY A;  5E5B A;  2BWV A;  2BWS A;  2GG8 A;  3FMQ A;  3MR1 A;  4RZZ A;  1C22 A;  1CHM A;  5JFR A;  2BHA A;  1R5G A;  1YW8 A;  3CTZ A;  1YW7 A;  4ZWO A;  4HXX A;  1WY2 A;  2GU4 A;  4PV4 A;  4S01 A;  4FO8 A;  5FCH A;  2GU6 A;  4FUK A;  3CB6 A;  4IKU A;  3PKB A;  4JUQ A;  1WL9 A;  2Q8K A;  3PKD A;  5CE6 A;  2GU5 A;  2ADU A;  4IKS A;  1R58 A;  4MAT A;  4ZWU A;  4PNC A;  4IKR A;  4FLJ A;  4U1B A;  1R5H A;  4U75 A;  3MX6 A;  1XGO A;  3IU8 A;  2Q96 A;  2P9A A;  4FKC A;  4IPA A;  1PV9 A;  3L24 A;  1M35 A;  1WBQ A;  2MAT A;  3PKA A;  2ZSG A;  4U76 A;  4QR8 A;  3L7G A;  3IU7 A;  4IF7 A;  1KP0 A;  1Y1N A;  2B3K A;  4RZY A;  1QXZ A;  2BWY A;  5CLS A;  1XGN A;  1XGM A;  2B3L A;  2Q92 A;  3FMR A;  4KM3 A;  4IDY A;  2Q95 A;  1W2M A;  1C23 A; 
#chains in the Genus database with same CATH topology
 2GG7 A;  2OAZ A;  1YJ3 A;  1MAT A;  2GGB A;  2Q94 A;  5D6F A;  3PKE A;  5FCF A;  2EVM A;  4U6Z A;  5JI6 A;  2BWT A;  2P99 A;  3D27 A;  4A6W A;  1JAW A;  2GG3 A;  2BWX A;  4IU6 A;  4S2R P;  4IEC A;  3BIT A;  1XGS A;  2DFI A;  2Q93 A;  2GG2 A;  4A6V A;  1C27 A;  1WKM A;  3MAT A;  1C24 A;  4U73 A;  2NQ6 A;  3TB5 A;  3RVA A;  2B3H A;  3IU9 A;  2BHB A;  5D6E A;  3BIQ A;  1C21 A;  2BN7 A;  1W7V A;  2BH3 A;  5CNX A;  2BB7 A;  4B28 A;  3BIP A;  2HOW A;  5CIK A;  2EVC A;  1A16 A;  2GTX A;  2EVO A;  3ROR A;  3PKC A;  4U71 A;  2GZ5 A;  1QXY A;  1BOA A;  2GA2 A;  1KQ0 A;  4FO7 A;  2BWU A;  3S6B A;  2V3X A;  4S2T P;  1N51 A;  1B59 A;  2GG5 A;  2GG9 A;  1WL6 A;  3IG4 A;  3Q6D A;  5CDE A;  1WLR A;  4FLI A;  4FLL A;  1BN5 A;  1YW9 A;  4R60 A;  5JHU A;  2GGC A;  2NQ7 A;  4U70 A;  2G6P A;  3CB5 A;  4RGZ 1;  1YVM A;  2V3Y A;  2EA2 A;  1B6A A;  3TAV A;  2GG0 A;  4OOK A;  4IKT A;  5CDV A;  4U6J A;  1QXW A;  4ZWP A;  2V6C A;  4U6C A;  5CDL A;  2BHD A;  2P98 A;  2V3Z A;  1O0X A;  4U6E A;  2EA4 A;  4Z7M A;  2GU7 A;  4U69 A;  3FM3 A;  2IW2 A;  4EGE A;  2BHC A;  2BWW A;  4S00 A;  1WN1 A;  4U6W A;  1XNZ A;  2OKN A;  4ZNG A;  1KQ9 A;  4FLK A;  1QZY A;  5E5B A;  2BWV A;  2BWS A;  2GG8 A;  3FMQ A;  3MR1 A;  4RZZ A;  1C22 A;  1CHM A;  5JFR A;  2BHA A;  1R5G A;  1YW8 A;  3CTZ A;  1YW7 A;  4ZWO A;  4HXX A;  1WY2 A;  2GU4 A;  4PV4 A;  4S01 A;  4FO8 A;  5FCH A;  2GU6 A;  4FUK A;  3CB6 A;  4IKU A;  3PKB A;  4JUQ A;  1WL9 A;  2Q8K A;  3PKD A;  5CE6 A;  2GU5 A;  2ADU A;  4IKS A;  1R58 A;  4MAT A;  4ZWU A;  4PNC A;  4IKR A;  4FLJ A;  4U1B A;  1R5H A;  4U75 A;  3MX6 A;  1XGO A;  3IU8 A;  2Q96 A;  2P9A A;  4FKC A;  4IPA A;  1PV9 A;  3L24 A;  1M35 A;  1WBQ A;  2MAT A;  3PKA A;  2ZSG A;  4U76 A;  4QR8 A;  3L7G A;  3IU7 A;  4IF7 A;  1KP0 A;  1Y1N A;  2B3K A;  4RZY A;  1QXZ A;  2BWY A;  5CLS A;  1XGN A;  1XGM A;  2B3L A;  2Q92 A;  3FMR A;  4KM3 A;  4IDY A;  2Q95 A;  1W2M A;  1C23 A; 
#chains in the Genus database with same CATH homology
 2GG7 A;  2OAZ A;  1YJ3 A;  1MAT A;  2GGB A;  2Q94 A;  5D6F A;  3PKE A;  5FCF A;  2EVM A;  4U6Z A;  5JI6 A;  2BWT A;  2P99 A;  3D27 A;  4A6W A;  1JAW A;  2GG3 A;  2BWX A;  4IU6 A;  4S2R P;  4IEC A;  3BIT A;  1XGS A;  2DFI A;  2Q93 A;  2GG2 A;  4A6V A;  1C27 A;  1WKM A;  3MAT A;  1C24 A;  4U73 A;  2NQ6 A;  3TB5 A;  3RVA A;  2B3H A;  3IU9 A;  2BHB A;  5D6E A;  3BIQ A;  1C21 A;  2BN7 A;  1W7V A;  2BH3 A;  5CNX A;  2BB7 A;  4B28 A;  3BIP A;  2HOW A;  5CIK A;  2EVC A;  1A16 A;  2GTX A;  2EVO A;  3ROR A;  3PKC A;  4U71 A;  2GZ5 A;  1QXY A;  1BOA A;  2GA2 A;  1KQ0 A;  4FO7 A;  2BWU A;  3S6B A;  2V3X A;  4S2T P;  1N51 A;  1B59 A;  2GG5 A;  2GG9 A;  1WL6 A;  3IG4 A;  3Q6D A;  5CDE A;  1WLR A;  4FLI A;  4FLL A;  1BN5 A;  1YW9 A;  4R60 A;  5JHU A;  2GGC A;  2NQ7 A;  4U70 A;  2G6P A;  3CB5 A;  4RGZ 1;  1YVM A;  2V3Y A;  2EA2 A;  1B6A A;  3TAV A;  2GG0 A;  4OOK A;  4IKT A;  5CDV A;  4U6J A;  1QXW A;  4ZWP A;  2V6C A;  4U6C A;  5CDL A;  2BHD A;  2P98 A;  2V3Z A;  1O0X A;  4U6E A;  2EA4 A;  4Z7M A;  2GU7 A;  4U69 A;  3FM3 A;  2IW2 A;  4EGE A;  2BHC A;  2BWW A;  4S00 A;  1WN1 A;  4U6W A;  1XNZ A;  2OKN A;  4ZNG A;  1KQ9 A;  4FLK A;  1QZY A;  5E5B A;  2BWV A;  2BWS A;  2GG8 A;  3FMQ A;  3MR1 A;  4RZZ A;  1C22 A;  1CHM A;  5JFR A;  2BHA A;  1R5G A;  1YW8 A;  3CTZ A;  1YW7 A;  4ZWO A;  4HXX A;  1WY2 A;  2GU4 A;  4PV4 A;  4S01 A;  4FO8 A;  5FCH A;  2GU6 A;  4FUK A;  3CB6 A;  4IKU A;  3PKB A;  4JUQ A;  1WL9 A;  2Q8K A;  3PKD A;  5CE6 A;  2GU5 A;  2ADU A;  4IKS A;  1R58 A;  4MAT A;  4ZWU A;  4PNC A;  4IKR A;  4FLJ A;  4U1B A;  1R5H A;  4U75 A;  3MX6 A;  1XGO A;  3IU8 A;  2Q96 A;  2P9A A;  4FKC A;  4IPA A;  1PV9 A;  3L24 A;  1M35 A;  1WBQ A;  2MAT A;  3PKA A;  2ZSG A;  4U76 A;  4QR8 A;  3L7G A;  3IU7 A;  4IF7 A;  1KP0 A;  1Y1N A;  2B3K A;  4RZY A;  1QXZ A;  2BWY A;  5CLS A;  1XGN A;  1XGM A;  2B3L A;  2Q92 A;  3FMR A;  4KM3 A;  4IDY A;  2Q95 A;  1W2M A;  1C23 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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