2GG3A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg3A00
1QXZA 2GG0A 3FMQA 2GU4A 1R58A 2V3YA 4IKUA 3TAVA 2Q95A 4FKCA 1WN1A 3IG4A 2EVOA 4U1BA 4U71A 1WKMA 3MATA 5CE6A 3IU7A 3PKDA 4A6WA 5CDLA 4U76A 5E5BA 2BHCA 2BWSA 2GZ5A 1PV9A 2EVMA 2BWXA 1MATA 1XGMA 3Q6DA 4ZWUA 1WY2A 5FCFA 2Q8KA 2BH3A 2GG3A 1WLRA 4ZNGA 4U70A 2BWWA 2EA2A 4S00A 2GG9A 5D6EA 4A6VA 4U73A 4Z7MA 1O0XA 2HOWA 5D6FA 3BIPA 4FO7A 4RGZ1 1WL9A 4U75A 2EA4A 2V3XA 1KQ0A 4R60A 1C27A 1A16A 4FUKA 4U69A 2Q96A 1C24A 1BOAA 3PKCA 2ADUA 4U6WA 3FMRA 4S2TP 2ZSGA 3MR1A 2IW2A 2BWUA 4JUQA 2OKNA 4HXXA 4IKRA 2DFIA 4B28A 1N51A 4FO8A 5CLSA 2GG2A 1XGSA 1YVMA 5FCHA 2NQ7A 1C22A 1WL6A 3L24A 2GU5A 4S01A 2EVCA 1Y1NA 4IECA 3IU9A 4FLKA 3RORA 2V3ZA 4RZZA 5JFRA 1WBQA 1KQ9A 4ZWPA 1CHMA 1XNZA 3CB5A 3RVAA 2BN7A 2GU6A 4U6ZA 2P99A 2BWTA 3BITA 3PKEA 5CNXA 1QZYA 3CTZA 3FM3A 4PV4A 1YJ3A 2NQ6A 3CB6A 4U6CA 2GGBA 5CDEA 2BHAA 4OOKA 4S2RP 5JHUA 1B59A 1YW8A 2GGCA 4FLIA 2G6PA 1C23A 1R5HA 2GA2A 1YW7A 2B3KA 3IU8A 5JI6A 4RZYA 2BB7A 1JAWA 1W2MA 2GG7A 2P98A 1QXYA 3PKBA 5CIKA 2MATA 2Q92A 2GG5A 1YW9A 4PNCA 1R5GA 2Q93A 2B3HA 1KP0A 3S6BA 4IU6A 4QR8A 4U6JA 4KM3A 3PKAA 1XGOA 4MATA 5CDVA 2B3LA 1W7VA 2P9AA 1B6AA 2GG8A 4IDYA 1QXWA 2BHBA 2GU7A 4IF7A 4EGEA 1XGNA 4IPAA 3L7GA 2Q94A 3D27A 4FLJA 1M35A 2V6CA 3BIQA 4FLLA 2BWVA 4U6EA 1BN5A 3MX6A 4IKTA 3TB5A 2BWYA 2GTXA 2OAZA 4IKSA 1C21A 4ZWOA 2BHDA
chains in the Genus database with same CATH superfamily
1QXZA 2GG0A 3FMQA 2GU4A 1R58A 2V3YA 4IKUA 3TAVA 2Q95A 4FKCA 1WN1A 3IG4A 2EVOA 4U1BA 4U71A 1WKMA 3MATA 5CE6A 3IU7A 3PKDA 4A6WA 5CDLA 4U76A 5E5BA 2BHCA 2BWSA 2GZ5A 1PV9A 2EVMA 2BWXA 1MATA 1XGMA 3Q6DA 4ZWUA 1WY2A 5FCFA 2Q8KA 2BH3A 2GG3A 1WLRA 4ZNGA 4U70A 2BWWA 2EA2A 4S00A 2GG9A 5D6EA 4A6VA 4U73A 4Z7MA 1O0XA 2HOWA 5D6FA 3BIPA 4FO7A 4RGZ1 1WL9A 4U75A 2EA4A 2V3XA 1KQ0A 4R60A 1C27A 1A16A 4FUKA 4U69A 2Q96A 1C24A 1BOAA 3PKCA 2ADUA 4U6WA 3FMRA 4S2TP 2ZSGA 3MR1A 2IW2A 2BWUA 4JUQA 2OKNA 4HXXA 4IKRA 2DFIA 4B28A 1N51A 4FO8A 5CLSA 2GG2A 1XGSA 1YVMA 5FCHA 2NQ7A 1C22A 1WL6A 3L24A 2GU5A 4S01A 2EVCA 1Y1NA 4IECA 3IU9A 4FLKA 3RORA 2V3ZA 4RZZA 5JFRA 1WBQA 1KQ9A 4ZWPA 1CHMA 1XNZA 3CB5A 3RVAA 2BN7A 2GU6A 4U6ZA 2P99A 2BWTA 3BITA 3PKEA 5CNXA 1QZYA 3CTZA 3FM3A 4PV4A 1YJ3A 2NQ6A 3CB6A 4U6CA 2GGBA 5CDEA 2BHAA 4OOKA 4S2RP 5JHUA 1B59A 1YW8A 2GGCA 4FLIA 2G6PA 1C23A 1R5HA 2GA2A 1YW7A 2B3KA 3IU8A 5JI6A 4RZYA 2BB7A 1JAWA 1W2MA 2GG7A 2P98A 1QXYA 3PKBA 5CIKA 2MATA 2Q92A 2GG5A 1YW9A 4PNCA 1R5GA 2Q93A 2B3HA 1KP0A 3S6BA 4IU6A 4QR8A 4U6JA 4KM3A 3PKAA 1XGOA 4MATA 5CDVA 2B3LA 1W7VA 2P9AA 1B6AA 2GG8A 4IDYA 1QXWA 2BHBA 2GU7A 4IF7A 4EGEA 1XGNA 4IPAA 3L7GA 2Q94A 3D27A 4FLJA 1M35A 2V6CA 3BIQA 4FLLA 2BWVA 4U6EA 1BN5A 3MX6A 4IKTA 3TB5A 2BWYA 2GTXA 2OAZA 4IKSA 1C21A 4ZWOA 2BHDA
chains in the Genus database with same CATH topology
1QXZA 2GG0A 3FMQA 2GU4A 1R58A 2V3YA 4IKUA 3TAVA 2Q95A 4FKCA 1WN1A 3IG4A 2EVOA 4U1BA 4U71A 1WKMA 3MATA 5CE6A 3IU7A 3PKDA 4A6WA 5CDLA 4U76A 5E5BA 2BHCA 2BWSA 2GZ5A 1PV9A 2EVMA 2BWXA 1MATA 1XGMA 3Q6DA 4ZWUA 1WY2A 5FCFA 2Q8KA 2BH3A 2GG3A 1WLRA 4ZNGA 4U70A 2BWWA 2EA2A 4S00A 2GG9A 5D6EA 4A6VA 4U73A 4Z7MA 1O0XA 2HOWA 5D6FA 3BIPA 4FO7A 4RGZ1 1WL9A 4U75A 2EA4A 2V3XA 1KQ0A 4R60A 1C27A 1A16A 4FUKA 4U69A 2Q96A 1C24A 1BOAA 3PKCA 2ADUA 4U6WA 3FMRA 4S2TP 2ZSGA 3MR1A 2IW2A 2BWUA 4JUQA 2OKNA 4HXXA 4IKRA 2DFIA 4B28A 1N51A 4FO8A 5CLSA 2GG2A 1XGSA 1YVMA 5FCHA 2NQ7A 1C22A 1WL6A 3L24A 2GU5A 4S01A 2EVCA 1Y1NA 4IECA 3IU9A 4FLKA 3RORA 2V3ZA 4RZZA 5JFRA 1WBQA 1KQ9A 4ZWPA 1CHMA 1XNZA 3CB5A 3RVAA 2BN7A 2GU6A 4U6ZA 2P99A 2BWTA 3BITA 3PKEA 5CNXA 1QZYA 3CTZA 3FM3A 4PV4A 1YJ3A 2NQ6A 3CB6A 4U6CA 2GGBA 5CDEA 2BHAA 4OOKA 4S2RP 5JHUA 1B59A 1YW8A 2GGCA 4FLIA 2G6PA 1C23A 1R5HA 2GA2A 1YW7A 2B3KA 3IU8A 5JI6A 4RZYA 2BB7A 1JAWA 1W2MA 2GG7A 2P98A 1QXYA 3PKBA 5CIKA 2MATA 2Q92A 2GG5A 1YW9A 4PNCA 1R5GA 2Q93A 2B3HA 1KP0A 3S6BA 4IU6A 4QR8A 4U6JA 4KM3A 3PKAA 1XGOA 4MATA 5CDVA 2B3LA 1W7VA 2P9AA 1B6AA 2GG8A 4IDYA 1QXWA 2BHBA 2GU7A 4IF7A 4EGEA 1XGNA 4IPAA 3L7GA 2Q94A 3D27A 4FLJA 1M35A 2V6CA 3BIQA 4FLLA 2BWVA 4U6EA 1BN5A 3MX6A 4IKTA 3TB5A 2BWYA 2GTXA 2OAZA 4IKSA 1C21A 4ZWOA 2BHDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QXZ A;  2GG0 A;  3FMQ A;  2GU4 A;  1R58 A;  2V3Y A;  4IKU A;  3TAV A;  2Q95 A;  4FKC A;  1WN1 A;  3IG4 A;  2EVO A;  4U1B A;  4U71 A;  1WKM A;  3MAT A;  5CE6 A;  3IU7 A;  3PKD A;  4A6W A;  5CDL A;  4U76 A;  5E5B A;  2BHC A;  2BWS A;  2GZ5 A;  1PV9 A;  2EVM A;  2BWX A;  1MAT A;  1XGM A;  3Q6D A;  4ZWU A;  1WY2 A;  5FCF A;  2Q8K A;  2BH3 A;  2GG3 A;  1WLR A;  4ZNG A;  4U70 A;  2BWW A;  2EA2 A;  4S00 A;  2GG9 A;  5D6E A;  4A6V A;  4U73 A;  4Z7M A;  1O0X A;  2HOW A;  5D6F A;  3BIP A;  4FO7 A;  4RGZ 1;  1WL9 A;  4U75 A;  2EA4 A;  2V3X A;  1KQ0 A;  4R60 A;  1C27 A;  1A16 A;  4FUK A;  4U69 A;  2Q96 A;  1C24 A;  1BOA A;  3PKC A;  2ADU A;  4U6W A;  3FMR A;  4S2T P;  2ZSG A;  3MR1 A;  2IW2 A;  2BWU A;  4JUQ A;  2OKN A;  4HXX A;  4IKR A;  2DFI A;  4B28 A;  1N51 A;  4FO8 A;  5CLS A;  2GG2 A;  1XGS A;  1YVM A;  5FCH A;  2NQ7 A;  1C22 A;  1WL6 A;  3L24 A;  2GU5 A;  4S01 A;  2EVC A;  1Y1N A;  4IEC A;  3IU9 A;  4FLK A;  3ROR A;  2V3Z A;  4RZZ A;  5JFR A;  1WBQ A;  1KQ9 A;  4ZWP A;  1CHM A;  1XNZ A;  3CB5 A;  3RVA A;  2BN7 A;  2GU6 A;  4U6Z A;  2P99 A;  2BWT A;  3BIT A;  3PKE A;  5CNX A;  1QZY A;  3CTZ A;  3FM3 A;  4PV4 A;  1YJ3 A;  2NQ6 A;  3CB6 A;  4U6C A;  2GGB A;  5CDE A;  2BHA A;  4OOK A;  4S2R P;  5JHU A;  1B59 A;  1YW8 A;  2GGC A;  4FLI A;  2G6P A;  1C23 A;  1R5H A;  2GA2 A;  1YW7 A;  2B3K A;  3IU8 A;  5JI6 A;  4RZY A;  2BB7 A;  1JAW A;  1W2M A;  2GG7 A;  2P98 A;  1QXY A;  3PKB A;  5CIK A;  2MAT A;  2Q92 A;  2GG5 A;  1YW9 A;  4PNC A;  1R5G A;  2Q93 A;  2B3H A;  1KP0 A;  3S6B A;  4IU6 A;  4QR8 A;  4U6J A;  4KM3 A;  3PKA A;  1XGO A;  4MAT A;  5CDV A;  2B3L A;  1W7V A;  2P9A A;  1B6A A;  2GG8 A;  4IDY A;  1QXW A;  2BHB A;  2GU7 A;  4IF7 A;  4EGE A;  1XGN A;  4IPA A;  3L7G A;  2Q94 A;  3D27 A;  4FLJ A;  1M35 A;  2V6C A;  3BIQ A;  4FLL A;  2BWV A;  4U6E A;  1BN5 A;  3MX6 A;  4IKT A;  3TB5 A;  2BWY A;  2GTX A;  2OAZ A;  4IKS A;  1C21 A;  4ZWO A;  2BHD A; 
#chains in the Genus database with same CATH topology
 1QXZ A;  2GG0 A;  3FMQ A;  2GU4 A;  1R58 A;  2V3Y A;  4IKU A;  3TAV A;  2Q95 A;  4FKC A;  1WN1 A;  3IG4 A;  2EVO A;  4U1B A;  4U71 A;  1WKM A;  3MAT A;  5CE6 A;  3IU7 A;  3PKD A;  4A6W A;  5CDL A;  4U76 A;  5E5B A;  2BHC A;  2BWS A;  2GZ5 A;  1PV9 A;  2EVM A;  2BWX A;  1MAT A;  1XGM A;  3Q6D A;  4ZWU A;  1WY2 A;  5FCF A;  2Q8K A;  2BH3 A;  2GG3 A;  1WLR A;  4ZNG A;  4U70 A;  2BWW A;  2EA2 A;  4S00 A;  2GG9 A;  5D6E A;  4A6V A;  4U73 A;  4Z7M A;  1O0X A;  2HOW A;  5D6F A;  3BIP A;  4FO7 A;  4RGZ 1;  1WL9 A;  4U75 A;  2EA4 A;  2V3X A;  1KQ0 A;  4R60 A;  1C27 A;  1A16 A;  4FUK A;  4U69 A;  2Q96 A;  1C24 A;  1BOA A;  3PKC A;  2ADU A;  4U6W A;  3FMR A;  4S2T P;  2ZSG A;  3MR1 A;  2IW2 A;  2BWU A;  4JUQ A;  2OKN A;  4HXX A;  4IKR A;  2DFI A;  4B28 A;  1N51 A;  4FO8 A;  5CLS A;  2GG2 A;  1XGS A;  1YVM A;  5FCH A;  2NQ7 A;  1C22 A;  1WL6 A;  3L24 A;  2GU5 A;  4S01 A;  2EVC A;  1Y1N A;  4IEC A;  3IU9 A;  4FLK A;  3ROR A;  2V3Z A;  4RZZ A;  5JFR A;  1WBQ A;  1KQ9 A;  4ZWP A;  1CHM A;  1XNZ A;  3CB5 A;  3RVA A;  2BN7 A;  2GU6 A;  4U6Z A;  2P99 A;  2BWT A;  3BIT A;  3PKE A;  5CNX A;  1QZY A;  3CTZ A;  3FM3 A;  4PV4 A;  1YJ3 A;  2NQ6 A;  3CB6 A;  4U6C A;  2GGB A;  5CDE A;  2BHA A;  4OOK A;  4S2R P;  5JHU A;  1B59 A;  1YW8 A;  2GGC A;  4FLI A;  2G6P A;  1C23 A;  1R5H A;  2GA2 A;  1YW7 A;  2B3K A;  3IU8 A;  5JI6 A;  4RZY A;  2BB7 A;  1JAW A;  1W2M A;  2GG7 A;  2P98 A;  1QXY A;  3PKB A;  5CIK A;  2MAT A;  2Q92 A;  2GG5 A;  1YW9 A;  4PNC A;  1R5G A;  2Q93 A;  2B3H A;  1KP0 A;  3S6B A;  4IU6 A;  4QR8 A;  4U6J A;  4KM3 A;  3PKA A;  1XGO A;  4MAT A;  5CDV A;  2B3L A;  1W7V A;  2P9A A;  1B6A A;  2GG8 A;  4IDY A;  1QXW A;  2BHB A;  2GU7 A;  4IF7 A;  4EGE A;  1XGN A;  4IPA A;  3L7G A;  2Q94 A;  3D27 A;  4FLJ A;  1M35 A;  2V6C A;  3BIQ A;  4FLL A;  2BWV A;  4U6E A;  1BN5 A;  3MX6 A;  4IKT A;  3TB5 A;  2BWY A;  2GTX A;  2OAZ A;  4IKS A;  1C21 A;  4ZWO A;  2BHD A; 
#chains in the Genus database with same CATH homology
 1QXZ A;  2GG0 A;  3FMQ A;  2GU4 A;  1R58 A;  2V3Y A;  4IKU A;  3TAV A;  2Q95 A;  4FKC A;  1WN1 A;  3IG4 A;  2EVO A;  4U1B A;  4U71 A;  1WKM A;  3MAT A;  5CE6 A;  3IU7 A;  3PKD A;  4A6W A;  5CDL A;  4U76 A;  5E5B A;  2BHC A;  2BWS A;  2GZ5 A;  1PV9 A;  2EVM A;  2BWX A;  1MAT A;  1XGM A;  3Q6D A;  4ZWU A;  1WY2 A;  5FCF A;  2Q8K A;  2BH3 A;  2GG3 A;  1WLR A;  4ZNG A;  4U70 A;  2BWW A;  2EA2 A;  4S00 A;  2GG9 A;  5D6E A;  4A6V A;  4U73 A;  4Z7M A;  1O0X A;  2HOW A;  5D6F A;  3BIP A;  4FO7 A;  4RGZ 1;  1WL9 A;  4U75 A;  2EA4 A;  2V3X A;  1KQ0 A;  4R60 A;  1C27 A;  1A16 A;  4FUK A;  4U69 A;  2Q96 A;  1C24 A;  1BOA A;  3PKC A;  2ADU A;  4U6W A;  3FMR A;  4S2T P;  2ZSG A;  3MR1 A;  2IW2 A;  2BWU A;  4JUQ A;  2OKN A;  4HXX A;  4IKR A;  2DFI A;  4B28 A;  1N51 A;  4FO8 A;  5CLS A;  2GG2 A;  1XGS A;  1YVM A;  5FCH A;  2NQ7 A;  1C22 A;  1WL6 A;  3L24 A;  2GU5 A;  4S01 A;  2EVC A;  1Y1N A;  4IEC A;  3IU9 A;  4FLK A;  3ROR A;  2V3Z A;  4RZZ A;  5JFR A;  1WBQ A;  1KQ9 A;  4ZWP A;  1CHM A;  1XNZ A;  3CB5 A;  3RVA A;  2BN7 A;  2GU6 A;  4U6Z A;  2P99 A;  2BWT A;  3BIT A;  3PKE A;  5CNX A;  1QZY A;  3CTZ A;  3FM3 A;  4PV4 A;  1YJ3 A;  2NQ6 A;  3CB6 A;  4U6C A;  2GGB A;  5CDE A;  2BHA A;  4OOK A;  4S2R P;  5JHU A;  1B59 A;  1YW8 A;  2GGC A;  4FLI A;  2G6P A;  1C23 A;  1R5H A;  2GA2 A;  1YW7 A;  2B3K A;  3IU8 A;  5JI6 A;  4RZY A;  2BB7 A;  1JAW A;  1W2M A;  2GG7 A;  2P98 A;  1QXY A;  3PKB A;  5CIK A;  2MAT A;  2Q92 A;  2GG5 A;  1YW9 A;  4PNC A;  1R5G A;  2Q93 A;  2B3H A;  1KP0 A;  3S6B A;  4IU6 A;  4QR8 A;  4U6J A;  4KM3 A;  3PKA A;  1XGO A;  4MAT A;  5CDV A;  2B3L A;  1W7V A;  2P9A A;  1B6A A;  2GG8 A;  4IDY A;  1QXW A;  2BHB A;  2GU7 A;  4IF7 A;  4EGE A;  1XGN A;  4IPA A;  3L7G A;  2Q94 A;  3D27 A;  4FLJ A;  1M35 A;  2V6C A;  3BIQ A;  4FLL A;  2BWV A;  4U6E A;  1BN5 A;  3MX6 A;  4IKT A;  3TB5 A;  2BWY A;  2GTX A;  2OAZ A;  4IKS A;  1C21 A;  4ZWO A;  2BHD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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