2GG5A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 81
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
81
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 81
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg5A00
2EVMA 2Q8KA 1W7VA 4IDYA 4IECA 5JI6A 2DFIA 2GGCA 3RORA 4QR8A 3MATA 2GA2A 2B3HA 2OKNA 3PKDA 1Y1NA 1YVMA 4U1BA 2GU4A 2BWWA 1YJ3A 1O0XA 4FLIA 1M35A 5D6EA 3RVAA 5E5BA 4ZNGA 4PNCA 2NQ7A 1WL9A 2GG9A 4PV4A 4R60A 2Q95A 4U6ZA 2V3XA 1R58A 4U6WA 3TB5A 1C23A 3FMQA 4ZWUA 4A6VA 2BWVA 3BIQA 4S2RP 1YW8A 4S00A 4U75A 1XGNA 1WLRA 2EA4A 3TAVA 1KQ9A 4U6EA 2BHBA 4RZZA 2GG8A 2GG3A 3PKEA 2BHDA 4U69A 3IU9A 3Q6DA 4IKSA 3PKAA 2BB7A 1C27A 1XNZA 2B3KA 2MATA 4U71A 1BN5A 4JUQA 4IF7A 3IG4A 1BOAA 1C21A 1WY2A 2BWYA 3FMRA 1N51A 4FLJA 2G6PA 5CE6A 5CIKA 4FLLA 3MX6A 1QZYA 2GG5A 4IKRA 4IU6A 2GG2A 2NQ6A 2B3LA 2GTXA 2V6CA 4U6CA 2GU7A 1R5GA 2EVCA 2ADUA 3IU7A 4FKCA 4RZYA 2EVOA 1B59A 4FO7A 4FUKA 4HXXA 5CNXA 4B28A 3BIPA 3FM3A 4S2TP 1QXYA 4EGEA 3L7GA 1MATA 5CLSA 4Z7MA 2GG7A 4FLKA 4ZWOA 2BHAA 5FCFA 2P99A 1B6AA 2BH3A 2GU5A 4IKUA 3S6BA 2Q94A 1CHMA 5JFRA 1WL6A 2GU6A 4OOKA 3BITA 2Q93A 3PKBA 3L24A 1XGOA 2HOWA 2BWSA 4MATA 4IKTA 2BWTA 4U70A 4U76A 2P98A 1JAWA 3MR1A 5CDVA 1QXWA 2ZSGA 2BN7A 1XGMA 1W2MA 1WN1A 4S01A 2OAZA 1KP0A 2IW2A 5D6FA 2P9AA 1C24A 3CTZA 4IPAA 1WKMA 1XGSA 2Q92A 3IU8A 4FO8A 5CDEA 5JHUA 3D27A 4RGZ1 2V3ZA 1WBQA 5FCHA 2GZ5A 2V3YA 2GGBA 5CDLA 2GG0A 1C22A 4U73A 1R5HA 3CB5A 3PKCA 4KM3A 4A6WA 1QXZA 3CB6A 2BHCA 1KQ0A 2EA2A 2Q96A 2BWXA 2BWUA 1PV9A 1YW7A 4U6JA 4ZWPA 1YW9A 1A16A
chains in the Genus database with same CATH superfamily
2EVMA 2Q8KA 1W7VA 4IDYA 4IECA 5JI6A 2DFIA 2GGCA 3RORA 4QR8A 3MATA 2GA2A 2B3HA 2OKNA 3PKDA 1Y1NA 1YVMA 4U1BA 2GU4A 2BWWA 1YJ3A 1O0XA 4FLIA 1M35A 5D6EA 3RVAA 5E5BA 4ZNGA 4PNCA 2NQ7A 1WL9A 2GG9A 4PV4A 4R60A 2Q95A 4U6ZA 2V3XA 1R58A 4U6WA 3TB5A 1C23A 3FMQA 4ZWUA 4A6VA 2BWVA 3BIQA 4S2RP 1YW8A 4S00A 4U75A 1XGNA 1WLRA 2EA4A 3TAVA 1KQ9A 4U6EA 2BHBA 4RZZA 2GG8A 2GG3A 3PKEA 2BHDA 4U69A 3IU9A 3Q6DA 4IKSA 3PKAA 2BB7A 1C27A 1XNZA 2B3KA 2MATA 4U71A 1BN5A 4JUQA 4IF7A 3IG4A 1BOAA 1C21A 1WY2A 2BWYA 3FMRA 1N51A 4FLJA 2G6PA 5CE6A 5CIKA 4FLLA 3MX6A 1QZYA 2GG5A 4IKRA 4IU6A 2GG2A 2NQ6A 2B3LA 2GTXA 2V6CA 4U6CA 2GU7A 1R5GA 2EVCA 2ADUA 3IU7A 4FKCA 4RZYA 2EVOA 1B59A 4FO7A 4FUKA 4HXXA 5CNXA 4B28A 3BIPA 3FM3A 4S2TP 1QXYA 4EGEA 3L7GA 1MATA 5CLSA 4Z7MA 2GG7A 4FLKA 4ZWOA 2BHAA 5FCFA 2P99A 1B6AA 2BH3A 2GU5A 4IKUA 3S6BA 2Q94A 1CHMA 5JFRA 1WL6A 2GU6A 4OOKA 3BITA 2Q93A 3PKBA 3L24A 1XGOA 2HOWA 2BWSA 4MATA 4IKTA 2BWTA 4U70A 4U76A 2P98A 1JAWA 3MR1A 5CDVA 1QXWA 2ZSGA 2BN7A 1XGMA 1W2MA 1WN1A 4S01A 2OAZA 1KP0A 2IW2A 5D6FA 2P9AA 1C24A 3CTZA 4IPAA 1WKMA 1XGSA 2Q92A 3IU8A 4FO8A 5CDEA 5JHUA 3D27A 4RGZ1 2V3ZA 1WBQA 5FCHA 2GZ5A 2V3YA 2GGBA 5CDLA 2GG0A 1C22A 4U73A 1R5HA 3CB5A 3PKCA 4KM3A 4A6WA 1QXZA 3CB6A 2BHCA 1KQ0A 2EA2A 2Q96A 2BWXA 2BWUA 1PV9A 1YW7A 4U6JA 4ZWPA 1YW9A 1A16A
chains in the Genus database with same CATH topology
2EVMA 2Q8KA 1W7VA 4IDYA 4IECA 5JI6A 2DFIA 2GGCA 3RORA 4QR8A 3MATA 2GA2A 2B3HA 2OKNA 3PKDA 1Y1NA 1YVMA 4U1BA 2GU4A 2BWWA 1YJ3A 1O0XA 4FLIA 1M35A 5D6EA 3RVAA 5E5BA 4ZNGA 4PNCA 2NQ7A 1WL9A 2GG9A 4PV4A 4R60A 2Q95A 4U6ZA 2V3XA 1R58A 4U6WA 3TB5A 1C23A 3FMQA 4ZWUA 4A6VA 2BWVA 3BIQA 4S2RP 1YW8A 4S00A 4U75A 1XGNA 1WLRA 2EA4A 3TAVA 1KQ9A 4U6EA 2BHBA 4RZZA 2GG8A 2GG3A 3PKEA 2BHDA 4U69A 3IU9A 3Q6DA 4IKSA 3PKAA 2BB7A 1C27A 1XNZA 2B3KA 2MATA 4U71A 1BN5A 4JUQA 4IF7A 3IG4A 1BOAA 1C21A 1WY2A 2BWYA 3FMRA 1N51A 4FLJA 2G6PA 5CE6A 5CIKA 4FLLA 3MX6A 1QZYA 2GG5A 4IKRA 4IU6A 2GG2A 2NQ6A 2B3LA 2GTXA 2V6CA 4U6CA 2GU7A 1R5GA 2EVCA 2ADUA 3IU7A 4FKCA 4RZYA 2EVOA 1B59A 4FO7A 4FUKA 4HXXA 5CNXA 4B28A 3BIPA 3FM3A 4S2TP 1QXYA 4EGEA 3L7GA 1MATA 5CLSA 4Z7MA 2GG7A 4FLKA 4ZWOA 2BHAA 5FCFA 2P99A 1B6AA 2BH3A 2GU5A 4IKUA 3S6BA 2Q94A 1CHMA 5JFRA 1WL6A 2GU6A 4OOKA 3BITA 2Q93A 3PKBA 3L24A 1XGOA 2HOWA 2BWSA 4MATA 4IKTA 2BWTA 4U70A 4U76A 2P98A 1JAWA 3MR1A 5CDVA 1QXWA 2ZSGA 2BN7A 1XGMA 1W2MA 1WN1A 4S01A 2OAZA 1KP0A 2IW2A 5D6FA 2P9AA 1C24A 3CTZA 4IPAA 1WKMA 1XGSA 2Q92A 3IU8A 4FO8A 5CDEA 5JHUA 3D27A 4RGZ1 2V3ZA 1WBQA 5FCHA 2GZ5A 2V3YA 2GGBA 5CDLA 2GG0A 1C22A 4U73A 1R5HA 3CB5A 3PKCA 4KM3A 4A6WA 1QXZA 3CB6A 2BHCA 1KQ0A 2EA2A 2Q96A 2BWXA 2BWUA 1PV9A 1YW7A 4U6JA 4ZWPA 1YW9A 1A16A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2EVM A;  2Q8K A;  1W7V A;  4IDY A;  4IEC A;  5JI6 A;  2DFI A;  2GGC A;  3ROR A;  4QR8 A;  3MAT A;  2GA2 A;  2B3H A;  2OKN A;  3PKD A;  1Y1N A;  1YVM A;  4U1B A;  2GU4 A;  2BWW A;  1YJ3 A;  1O0X A;  4FLI A;  1M35 A;  5D6E A;  3RVA A;  5E5B A;  4ZNG A;  4PNC A;  2NQ7 A;  1WL9 A;  2GG9 A;  4PV4 A;  4R60 A;  2Q95 A;  4U6Z A;  2V3X A;  1R58 A;  4U6W A;  3TB5 A;  1C23 A;  3FMQ A;  4ZWU A;  4A6V A;  2BWV A;  3BIQ A;  4S2R P;  1YW8 A;  4S00 A;  4U75 A;  1XGN A;  1WLR A;  2EA4 A;  3TAV A;  1KQ9 A;  4U6E A;  2BHB A;  4RZZ A;  2GG8 A;  2GG3 A;  3PKE A;  2BHD A;  4U69 A;  3IU9 A;  3Q6D A;  4IKS A;  3PKA A;  2BB7 A;  1C27 A;  1XNZ A;  2B3K A;  2MAT A;  4U71 A;  1BN5 A;  4JUQ A;  4IF7 A;  3IG4 A;  1BOA A;  1C21 A;  1WY2 A;  2BWY A;  3FMR A;  1N51 A;  4FLJ A;  2G6P A;  5CE6 A;  5CIK A;  4FLL A;  3MX6 A;  1QZY A;  2GG5 A;  4IKR A;  4IU6 A;  2GG2 A;  2NQ6 A;  2B3L A;  2GTX A;  2V6C A;  4U6C A;  2GU7 A;  1R5G A;  2EVC A;  2ADU A;  3IU7 A;  4FKC A;  4RZY A;  2EVO A;  1B59 A;  4FO7 A;  4FUK A;  4HXX A;  5CNX A;  4B28 A;  3BIP A;  3FM3 A;  4S2T P;  1QXY A;  4EGE A;  3L7G A;  1MAT A;  5CLS A;  4Z7M A;  2GG7 A;  4FLK A;  4ZWO A;  2BHA A;  5FCF A;  2P99 A;  1B6A A;  2BH3 A;  2GU5 A;  4IKU A;  3S6B A;  2Q94 A;  1CHM A;  5JFR A;  1WL6 A;  2GU6 A;  4OOK A;  3BIT A;  2Q93 A;  3PKB A;  3L24 A;  1XGO A;  2HOW A;  2BWS A;  4MAT A;  4IKT A;  2BWT A;  4U70 A;  4U76 A;  2P98 A;  1JAW A;  3MR1 A;  5CDV A;  1QXW A;  2ZSG A;  2BN7 A;  1XGM A;  1W2M A;  1WN1 A;  4S01 A;  2OAZ A;  1KP0 A;  2IW2 A;  5D6F A;  2P9A A;  1C24 A;  3CTZ A;  4IPA A;  1WKM A;  1XGS A;  2Q92 A;  3IU8 A;  4FO8 A;  5CDE A;  5JHU A;  3D27 A;  4RGZ 1;  2V3Z A;  1WBQ A;  5FCH A;  2GZ5 A;  2V3Y A;  2GGB A;  5CDL A;  2GG0 A;  1C22 A;  4U73 A;  1R5H A;  3CB5 A;  3PKC A;  4KM3 A;  4A6W A;  1QXZ A;  3CB6 A;  2BHC A;  1KQ0 A;  2EA2 A;  2Q96 A;  2BWX A;  2BWU A;  1PV9 A;  1YW7 A;  4U6J A;  4ZWP A;  1YW9 A;  1A16 A; 
#chains in the Genus database with same CATH topology
 2EVM A;  2Q8K A;  1W7V A;  4IDY A;  4IEC A;  5JI6 A;  2DFI A;  2GGC A;  3ROR A;  4QR8 A;  3MAT A;  2GA2 A;  2B3H A;  2OKN A;  3PKD A;  1Y1N A;  1YVM A;  4U1B A;  2GU4 A;  2BWW A;  1YJ3 A;  1O0X A;  4FLI A;  1M35 A;  5D6E A;  3RVA A;  5E5B A;  4ZNG A;  4PNC A;  2NQ7 A;  1WL9 A;  2GG9 A;  4PV4 A;  4R60 A;  2Q95 A;  4U6Z A;  2V3X A;  1R58 A;  4U6W A;  3TB5 A;  1C23 A;  3FMQ A;  4ZWU A;  4A6V A;  2BWV A;  3BIQ A;  4S2R P;  1YW8 A;  4S00 A;  4U75 A;  1XGN A;  1WLR A;  2EA4 A;  3TAV A;  1KQ9 A;  4U6E A;  2BHB A;  4RZZ A;  2GG8 A;  2GG3 A;  3PKE A;  2BHD A;  4U69 A;  3IU9 A;  3Q6D A;  4IKS A;  3PKA A;  2BB7 A;  1C27 A;  1XNZ A;  2B3K A;  2MAT A;  4U71 A;  1BN5 A;  4JUQ A;  4IF7 A;  3IG4 A;  1BOA A;  1C21 A;  1WY2 A;  2BWY A;  3FMR A;  1N51 A;  4FLJ A;  2G6P A;  5CE6 A;  5CIK A;  4FLL A;  3MX6 A;  1QZY A;  2GG5 A;  4IKR A;  4IU6 A;  2GG2 A;  2NQ6 A;  2B3L A;  2GTX A;  2V6C A;  4U6C A;  2GU7 A;  1R5G A;  2EVC A;  2ADU A;  3IU7 A;  4FKC A;  4RZY A;  2EVO A;  1B59 A;  4FO7 A;  4FUK A;  4HXX A;  5CNX A;  4B28 A;  3BIP A;  3FM3 A;  4S2T P;  1QXY A;  4EGE A;  3L7G A;  1MAT A;  5CLS A;  4Z7M A;  2GG7 A;  4FLK A;  4ZWO A;  2BHA A;  5FCF A;  2P99 A;  1B6A A;  2BH3 A;  2GU5 A;  4IKU A;  3S6B A;  2Q94 A;  1CHM A;  5JFR A;  1WL6 A;  2GU6 A;  4OOK A;  3BIT A;  2Q93 A;  3PKB A;  3L24 A;  1XGO A;  2HOW A;  2BWS A;  4MAT A;  4IKT A;  2BWT A;  4U70 A;  4U76 A;  2P98 A;  1JAW A;  3MR1 A;  5CDV A;  1QXW A;  2ZSG A;  2BN7 A;  1XGM A;  1W2M A;  1WN1 A;  4S01 A;  2OAZ A;  1KP0 A;  2IW2 A;  5D6F A;  2P9A A;  1C24 A;  3CTZ A;  4IPA A;  1WKM A;  1XGS A;  2Q92 A;  3IU8 A;  4FO8 A;  5CDE A;  5JHU A;  3D27 A;  4RGZ 1;  2V3Z A;  1WBQ A;  5FCH A;  2GZ5 A;  2V3Y A;  2GGB A;  5CDL A;  2GG0 A;  1C22 A;  4U73 A;  1R5H A;  3CB5 A;  3PKC A;  4KM3 A;  4A6W A;  1QXZ A;  3CB6 A;  2BHC A;  1KQ0 A;  2EA2 A;  2Q96 A;  2BWX A;  2BWU A;  1PV9 A;  1YW7 A;  4U6J A;  4ZWP A;  1YW9 A;  1A16 A; 
#chains in the Genus database with same CATH homology
 2EVM A;  2Q8K A;  1W7V A;  4IDY A;  4IEC A;  5JI6 A;  2DFI A;  2GGC A;  3ROR A;  4QR8 A;  3MAT A;  2GA2 A;  2B3H A;  2OKN A;  3PKD A;  1Y1N A;  1YVM A;  4U1B A;  2GU4 A;  2BWW A;  1YJ3 A;  1O0X A;  4FLI A;  1M35 A;  5D6E A;  3RVA A;  5E5B A;  4ZNG A;  4PNC A;  2NQ7 A;  1WL9 A;  2GG9 A;  4PV4 A;  4R60 A;  2Q95 A;  4U6Z A;  2V3X A;  1R58 A;  4U6W A;  3TB5 A;  1C23 A;  3FMQ A;  4ZWU A;  4A6V A;  2BWV A;  3BIQ A;  4S2R P;  1YW8 A;  4S00 A;  4U75 A;  1XGN A;  1WLR A;  2EA4 A;  3TAV A;  1KQ9 A;  4U6E A;  2BHB A;  4RZZ A;  2GG8 A;  2GG3 A;  3PKE A;  2BHD A;  4U69 A;  3IU9 A;  3Q6D A;  4IKS A;  3PKA A;  2BB7 A;  1C27 A;  1XNZ A;  2B3K A;  2MAT A;  4U71 A;  1BN5 A;  4JUQ A;  4IF7 A;  3IG4 A;  1BOA A;  1C21 A;  1WY2 A;  2BWY A;  3FMR A;  1N51 A;  4FLJ A;  2G6P A;  5CE6 A;  5CIK A;  4FLL A;  3MX6 A;  1QZY A;  2GG5 A;  4IKR A;  4IU6 A;  2GG2 A;  2NQ6 A;  2B3L A;  2GTX A;  2V6C A;  4U6C A;  2GU7 A;  1R5G A;  2EVC A;  2ADU A;  3IU7 A;  4FKC A;  4RZY A;  2EVO A;  1B59 A;  4FO7 A;  4FUK A;  4HXX A;  5CNX A;  4B28 A;  3BIP A;  3FM3 A;  4S2T P;  1QXY A;  4EGE A;  3L7G A;  1MAT A;  5CLS A;  4Z7M A;  2GG7 A;  4FLK A;  4ZWO A;  2BHA A;  5FCF A;  2P99 A;  1B6A A;  2BH3 A;  2GU5 A;  4IKU A;  3S6B A;  2Q94 A;  1CHM A;  5JFR A;  1WL6 A;  2GU6 A;  4OOK A;  3BIT A;  2Q93 A;  3PKB A;  3L24 A;  1XGO A;  2HOW A;  2BWS A;  4MAT A;  4IKT A;  2BWT A;  4U70 A;  4U76 A;  2P98 A;  1JAW A;  3MR1 A;  5CDV A;  1QXW A;  2ZSG A;  2BN7 A;  1XGM A;  1W2M A;  1WN1 A;  4S01 A;  2OAZ A;  1KP0 A;  2IW2 A;  5D6F A;  2P9A A;  1C24 A;  3CTZ A;  4IPA A;  1WKM A;  1XGS A;  2Q92 A;  3IU8 A;  4FO8 A;  5CDE A;  5JHU A;  3D27 A;  4RGZ 1;  2V3Z A;  1WBQ A;  5FCH A;  2GZ5 A;  2V3Y A;  2GGB A;  5CDL A;  2GG0 A;  1C22 A;  4U73 A;  1R5H A;  3CB5 A;  3PKC A;  4KM3 A;  4A6W A;  1QXZ A;  3CB6 A;  2BHC A;  1KQ0 A;  2EA2 A;  2Q96 A;  2BWX A;  2BWU A;  1PV9 A;  1YW7 A;  4U6J A;  4ZWP A;  1YW9 A;  1A16 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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