2GG7A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 85
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg7A00
1M35A 4FO8A 2BN7A 2G6PA 2BB7A 1W2MA 2GGCA 2ZSGA 4IKSA 1W7VA 4PNCA 4IDYA 5FCHA 4FLKA 4FKCA 2EA2A 2Q96A 1YW8A 2NQ6A 1O0XA 2BWUA 2BHAA 5CE6A 2GGBA 4A6WA 2Q93A 1CHMA 3Q6DA 4ZWPA 3PKEA 1XGNA 4IKTA 1C21A 1WL6A 3IU8A 5CDEA 2V3ZA 2BHCA 3PKAA 1XGSA 2B3HA 4IKRA 4R60A 4FUKA 4MATA 1XNZA 4S00A 4RZYA 1QZYA 5CDVA 4IU6A 1PV9A 4U6EA 2BWWA 2OAZA 4A6VA 1KQ0A 3BIPA 3FM3A 3RORA 1C23A 1KQ9A 3RVAA 2P98A 2GU7A 2V3XA 4ZWOA 2EVOA 3CTZA 1YW7A 2BWSA 1C22A 1C24A 4IPAA 2EVCA 1KP0A 4S2TP 4U70A 1B59A 3FMRA 2GTXA 4FLIA 4ZWUA 1QXZA 3S6BA 1YW9A 1R58A 2GU5A 1WKMA 2NQ7A 1QXWA 4S2RP 2BHDA 2EA4A 4OOKA 1WY2A 1N51A 2B3LA 2Q92A 3PKDA 1WLRA 3PKBA 2V3YA 4FO7A 2V6CA 4U6JA 5FCFA 2GU4A 5CIKA 2MATA 2Q95A 4EGEA 4IECA 3TAVA 1BOAA 1MATA 2GG8A 1WL9A 2ADUA 4U73A 5JHUA 5D6EA 3MR1A 4S01A 4U6CA 2GG9A 2Q94A 2EVMA 2GG3A 1Y1NA 1C27A 1JAWA 2BH3A 2HOWA 3D27A 2BWYA 2Q8KA 2B3KA 4JUQA 1WBQA 1YJ3A 4U69A 1BN5A 1XGMA 3CB6A 3IU7A 4ZNGA 3IU9A 2BWXA 2BHBA 2GA2A 1R5GA 2GZ5A 2OKNA 2GU6A 3MX6A 1A16A 1B6AA 1QXYA 2P99A 4PV4A 4IKUA 2BWVA 5CLSA 5JFRA 3L7GA 4RZZA 1WN1A 4HXXA 3FMQA 4U6ZA 4B28A 3TB5A 4FLJA 4KM3A 2DFIA 2GG0A 3IG4A 3BIQA 1R5HA 4FLLA 1XGOA 4QR8A 4RGZ1 5JI6A 3CB5A 4Z7MA 2GG2A 5CDLA 2GG7A 5D6FA 3L24A 4U1BA 4U6WA 4U75A 5E5BA 2BWTA 4IF7A 2GG5A 3MATA 3PKCA 4U71A 4U76A 5CNXA 3BITA 1YVMA 2P9AA 2IW2A
chains in the Genus database with same CATH superfamily
1M35A 4FO8A 2BN7A 2G6PA 2BB7A 1W2MA 2GGCA 2ZSGA 4IKSA 1W7VA 4PNCA 4IDYA 5FCHA 4FLKA 4FKCA 2EA2A 2Q96A 1YW8A 2NQ6A 1O0XA 2BWUA 2BHAA 5CE6A 2GGBA 4A6WA 2Q93A 1CHMA 3Q6DA 4ZWPA 3PKEA 1XGNA 4IKTA 1C21A 1WL6A 3IU8A 5CDEA 2V3ZA 2BHCA 3PKAA 1XGSA 2B3HA 4IKRA 4R60A 4FUKA 4MATA 1XNZA 4S00A 4RZYA 1QZYA 5CDVA 4IU6A 1PV9A 4U6EA 2BWWA 2OAZA 4A6VA 1KQ0A 3BIPA 3FM3A 3RORA 1C23A 1KQ9A 3RVAA 2P98A 2GU7A 2V3XA 4ZWOA 2EVOA 3CTZA 1YW7A 2BWSA 1C22A 1C24A 4IPAA 2EVCA 1KP0A 4S2TP 4U70A 1B59A 3FMRA 2GTXA 4FLIA 4ZWUA 1QXZA 3S6BA 1YW9A 1R58A 2GU5A 1WKMA 2NQ7A 1QXWA 4S2RP 2BHDA 2EA4A 4OOKA 1WY2A 1N51A 2B3LA 2Q92A 3PKDA 1WLRA 3PKBA 2V3YA 4FO7A 2V6CA 4U6JA 5FCFA 2GU4A 5CIKA 2MATA 2Q95A 4EGEA 4IECA 3TAVA 1BOAA 1MATA 2GG8A 1WL9A 2ADUA 4U73A 5JHUA 5D6EA 3MR1A 4S01A 4U6CA 2GG9A 2Q94A 2EVMA 2GG3A 1Y1NA 1C27A 1JAWA 2BH3A 2HOWA 3D27A 2BWYA 2Q8KA 2B3KA 4JUQA 1WBQA 1YJ3A 4U69A 1BN5A 1XGMA 3CB6A 3IU7A 4ZNGA 3IU9A 2BWXA 2BHBA 2GA2A 1R5GA 2GZ5A 2OKNA 2GU6A 3MX6A 1A16A 1B6AA 1QXYA 2P99A 4PV4A 4IKUA 2BWVA 5CLSA 5JFRA 3L7GA 4RZZA 1WN1A 4HXXA 3FMQA 4U6ZA 4B28A 3TB5A 4FLJA 4KM3A 2DFIA 2GG0A 3IG4A 3BIQA 1R5HA 4FLLA 1XGOA 4QR8A 4RGZ1 5JI6A 3CB5A 4Z7MA 2GG2A 5CDLA 2GG7A 5D6FA 3L24A 4U1BA 4U6WA 4U75A 5E5BA 2BWTA 4IF7A 2GG5A 3MATA 3PKCA 4U71A 4U76A 5CNXA 3BITA 1YVMA 2P9AA 2IW2A
chains in the Genus database with same CATH topology
1M35A 4FO8A 2BN7A 2G6PA 2BB7A 1W2MA 2GGCA 2ZSGA 4IKSA 1W7VA 4PNCA 4IDYA 5FCHA 4FLKA 4FKCA 2EA2A 2Q96A 1YW8A 2NQ6A 1O0XA 2BWUA 2BHAA 5CE6A 2GGBA 4A6WA 2Q93A 1CHMA 3Q6DA 4ZWPA 3PKEA 1XGNA 4IKTA 1C21A 1WL6A 3IU8A 5CDEA 2V3ZA 2BHCA 3PKAA 1XGSA 2B3HA 4IKRA 4R60A 4FUKA 4MATA 1XNZA 4S00A 4RZYA 1QZYA 5CDVA 4IU6A 1PV9A 4U6EA 2BWWA 2OAZA 4A6VA 1KQ0A 3BIPA 3FM3A 3RORA 1C23A 1KQ9A 3RVAA 2P98A 2GU7A 2V3XA 4ZWOA 2EVOA 3CTZA 1YW7A 2BWSA 1C22A 1C24A 4IPAA 2EVCA 1KP0A 4S2TP 4U70A 1B59A 3FMRA 2GTXA 4FLIA 4ZWUA 1QXZA 3S6BA 1YW9A 1R58A 2GU5A 1WKMA 2NQ7A 1QXWA 4S2RP 2BHDA 2EA4A 4OOKA 1WY2A 1N51A 2B3LA 2Q92A 3PKDA 1WLRA 3PKBA 2V3YA 4FO7A 2V6CA 4U6JA 5FCFA 2GU4A 5CIKA 2MATA 2Q95A 4EGEA 4IECA 3TAVA 1BOAA 1MATA 2GG8A 1WL9A 2ADUA 4U73A 5JHUA 5D6EA 3MR1A 4S01A 4U6CA 2GG9A 2Q94A 2EVMA 2GG3A 1Y1NA 1C27A 1JAWA 2BH3A 2HOWA 3D27A 2BWYA 2Q8KA 2B3KA 4JUQA 1WBQA 1YJ3A 4U69A 1BN5A 1XGMA 3CB6A 3IU7A 4ZNGA 3IU9A 2BWXA 2BHBA 2GA2A 1R5GA 2GZ5A 2OKNA 2GU6A 3MX6A 1A16A 1B6AA 1QXYA 2P99A 4PV4A 4IKUA 2BWVA 5CLSA 5JFRA 3L7GA 4RZZA 1WN1A 4HXXA 3FMQA 4U6ZA 4B28A 3TB5A 4FLJA 4KM3A 2DFIA 2GG0A 3IG4A 3BIQA 1R5HA 4FLLA 1XGOA 4QR8A 4RGZ1 5JI6A 3CB5A 4Z7MA 2GG2A 5CDLA 2GG7A 5D6FA 3L24A 4U1BA 4U6WA 4U75A 5E5BA 2BWTA 4IF7A 2GG5A 3MATA 3PKCA 4U71A 4U76A 5CNXA 3BITA 1YVMA 2P9AA 2IW2A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1M35 A;  4FO8 A;  2BN7 A;  2G6P A;  2BB7 A;  1W2M A;  2GGC A;  2ZSG A;  4IKS A;  1W7V A;  4PNC A;  4IDY A;  5FCH A;  4FLK A;  4FKC A;  2EA2 A;  2Q96 A;  1YW8 A;  2NQ6 A;  1O0X A;  2BWU A;  2BHA A;  5CE6 A;  2GGB A;  4A6W A;  2Q93 A;  1CHM A;  3Q6D A;  4ZWP A;  3PKE A;  1XGN A;  4IKT A;  1C21 A;  1WL6 A;  3IU8 A;  5CDE A;  2V3Z A;  2BHC A;  3PKA A;  1XGS A;  2B3H A;  4IKR A;  4R60 A;  4FUK A;  4MAT A;  1XNZ A;  4S00 A;  4RZY A;  1QZY A;  5CDV A;  4IU6 A;  1PV9 A;  4U6E A;  2BWW A;  2OAZ A;  4A6V A;  1KQ0 A;  3BIP A;  3FM3 A;  3ROR A;  1C23 A;  1KQ9 A;  3RVA A;  2P98 A;  2GU7 A;  2V3X A;  4ZWO A;  2EVO A;  3CTZ A;  1YW7 A;  2BWS A;  1C22 A;  1C24 A;  4IPA A;  2EVC A;  1KP0 A;  4S2T P;  4U70 A;  1B59 A;  3FMR A;  2GTX A;  4FLI A;  4ZWU A;  1QXZ A;  3S6B A;  1YW9 A;  1R58 A;  2GU5 A;  1WKM A;  2NQ7 A;  1QXW A;  4S2R P;  2BHD A;  2EA4 A;  4OOK A;  1WY2 A;  1N51 A;  2B3L A;  2Q92 A;  3PKD A;  1WLR A;  3PKB A;  2V3Y A;  4FO7 A;  2V6C A;  4U6J A;  5FCF A;  2GU4 A;  5CIK A;  2MAT A;  2Q95 A;  4EGE A;  4IEC A;  3TAV A;  1BOA A;  1MAT A;  2GG8 A;  1WL9 A;  2ADU A;  4U73 A;  5JHU A;  5D6E A;  3MR1 A;  4S01 A;  4U6C A;  2GG9 A;  2Q94 A;  2EVM A;  2GG3 A;  1Y1N A;  1C27 A;  1JAW A;  2BH3 A;  2HOW A;  3D27 A;  2BWY A;  2Q8K A;  2B3K A;  4JUQ A;  1WBQ A;  1YJ3 A;  4U69 A;  1BN5 A;  1XGM A;  3CB6 A;  3IU7 A;  4ZNG A;  3IU9 A;  2BWX A;  2BHB A;  2GA2 A;  1R5G A;  2GZ5 A;  2OKN A;  2GU6 A;  3MX6 A;  1A16 A;  1B6A A;  1QXY A;  2P99 A;  4PV4 A;  4IKU A;  2BWV A;  5CLS A;  5JFR A;  3L7G A;  4RZZ A;  1WN1 A;  4HXX A;  3FMQ A;  4U6Z A;  4B28 A;  3TB5 A;  4FLJ A;  4KM3 A;  2DFI A;  2GG0 A;  3IG4 A;  3BIQ A;  1R5H A;  4FLL A;  1XGO A;  4QR8 A;  4RGZ 1;  5JI6 A;  3CB5 A;  4Z7M A;  2GG2 A;  5CDL A;  2GG7 A;  5D6F A;  3L24 A;  4U1B A;  4U6W A;  4U75 A;  5E5B A;  2BWT A;  4IF7 A;  2GG5 A;  3MAT A;  3PKC A;  4U71 A;  4U76 A;  5CNX A;  3BIT A;  1YVM A;  2P9A A;  2IW2 A; 
#chains in the Genus database with same CATH topology
 1M35 A;  4FO8 A;  2BN7 A;  2G6P A;  2BB7 A;  1W2M A;  2GGC A;  2ZSG A;  4IKS A;  1W7V A;  4PNC A;  4IDY A;  5FCH A;  4FLK A;  4FKC A;  2EA2 A;  2Q96 A;  1YW8 A;  2NQ6 A;  1O0X A;  2BWU A;  2BHA A;  5CE6 A;  2GGB A;  4A6W A;  2Q93 A;  1CHM A;  3Q6D A;  4ZWP A;  3PKE A;  1XGN A;  4IKT A;  1C21 A;  1WL6 A;  3IU8 A;  5CDE A;  2V3Z A;  2BHC A;  3PKA A;  1XGS A;  2B3H A;  4IKR A;  4R60 A;  4FUK A;  4MAT A;  1XNZ A;  4S00 A;  4RZY A;  1QZY A;  5CDV A;  4IU6 A;  1PV9 A;  4U6E A;  2BWW A;  2OAZ A;  4A6V A;  1KQ0 A;  3BIP A;  3FM3 A;  3ROR A;  1C23 A;  1KQ9 A;  3RVA A;  2P98 A;  2GU7 A;  2V3X A;  4ZWO A;  2EVO A;  3CTZ A;  1YW7 A;  2BWS A;  1C22 A;  1C24 A;  4IPA A;  2EVC A;  1KP0 A;  4S2T P;  4U70 A;  1B59 A;  3FMR A;  2GTX A;  4FLI A;  4ZWU A;  1QXZ A;  3S6B A;  1YW9 A;  1R58 A;  2GU5 A;  1WKM A;  2NQ7 A;  1QXW A;  4S2R P;  2BHD A;  2EA4 A;  4OOK A;  1WY2 A;  1N51 A;  2B3L A;  2Q92 A;  3PKD A;  1WLR A;  3PKB A;  2V3Y A;  4FO7 A;  2V6C A;  4U6J A;  5FCF A;  2GU4 A;  5CIK A;  2MAT A;  2Q95 A;  4EGE A;  4IEC A;  3TAV A;  1BOA A;  1MAT A;  2GG8 A;  1WL9 A;  2ADU A;  4U73 A;  5JHU A;  5D6E A;  3MR1 A;  4S01 A;  4U6C A;  2GG9 A;  2Q94 A;  2EVM A;  2GG3 A;  1Y1N A;  1C27 A;  1JAW A;  2BH3 A;  2HOW A;  3D27 A;  2BWY A;  2Q8K A;  2B3K A;  4JUQ A;  1WBQ A;  1YJ3 A;  4U69 A;  1BN5 A;  1XGM A;  3CB6 A;  3IU7 A;  4ZNG A;  3IU9 A;  2BWX A;  2BHB A;  2GA2 A;  1R5G A;  2GZ5 A;  2OKN A;  2GU6 A;  3MX6 A;  1A16 A;  1B6A A;  1QXY A;  2P99 A;  4PV4 A;  4IKU A;  2BWV A;  5CLS A;  5JFR A;  3L7G A;  4RZZ A;  1WN1 A;  4HXX A;  3FMQ A;  4U6Z A;  4B28 A;  3TB5 A;  4FLJ A;  4KM3 A;  2DFI A;  2GG0 A;  3IG4 A;  3BIQ A;  1R5H A;  4FLL A;  1XGO A;  4QR8 A;  4RGZ 1;  5JI6 A;  3CB5 A;  4Z7M A;  2GG2 A;  5CDL A;  2GG7 A;  5D6F A;  3L24 A;  4U1B A;  4U6W A;  4U75 A;  5E5B A;  2BWT A;  4IF7 A;  2GG5 A;  3MAT A;  3PKC A;  4U71 A;  4U76 A;  5CNX A;  3BIT A;  1YVM A;  2P9A A;  2IW2 A; 
#chains in the Genus database with same CATH homology
 1M35 A;  4FO8 A;  2BN7 A;  2G6P A;  2BB7 A;  1W2M A;  2GGC A;  2ZSG A;  4IKS A;  1W7V A;  4PNC A;  4IDY A;  5FCH A;  4FLK A;  4FKC A;  2EA2 A;  2Q96 A;  1YW8 A;  2NQ6 A;  1O0X A;  2BWU A;  2BHA A;  5CE6 A;  2GGB A;  4A6W A;  2Q93 A;  1CHM A;  3Q6D A;  4ZWP A;  3PKE A;  1XGN A;  4IKT A;  1C21 A;  1WL6 A;  3IU8 A;  5CDE A;  2V3Z A;  2BHC A;  3PKA A;  1XGS A;  2B3H A;  4IKR A;  4R60 A;  4FUK A;  4MAT A;  1XNZ A;  4S00 A;  4RZY A;  1QZY A;  5CDV A;  4IU6 A;  1PV9 A;  4U6E A;  2BWW A;  2OAZ A;  4A6V A;  1KQ0 A;  3BIP A;  3FM3 A;  3ROR A;  1C23 A;  1KQ9 A;  3RVA A;  2P98 A;  2GU7 A;  2V3X A;  4ZWO A;  2EVO A;  3CTZ A;  1YW7 A;  2BWS A;  1C22 A;  1C24 A;  4IPA A;  2EVC A;  1KP0 A;  4S2T P;  4U70 A;  1B59 A;  3FMR A;  2GTX A;  4FLI A;  4ZWU A;  1QXZ A;  3S6B A;  1YW9 A;  1R58 A;  2GU5 A;  1WKM A;  2NQ7 A;  1QXW A;  4S2R P;  2BHD A;  2EA4 A;  4OOK A;  1WY2 A;  1N51 A;  2B3L A;  2Q92 A;  3PKD A;  1WLR A;  3PKB A;  2V3Y A;  4FO7 A;  2V6C A;  4U6J A;  5FCF A;  2GU4 A;  5CIK A;  2MAT A;  2Q95 A;  4EGE A;  4IEC A;  3TAV A;  1BOA A;  1MAT A;  2GG8 A;  1WL9 A;  2ADU A;  4U73 A;  5JHU A;  5D6E A;  3MR1 A;  4S01 A;  4U6C A;  2GG9 A;  2Q94 A;  2EVM A;  2GG3 A;  1Y1N A;  1C27 A;  1JAW A;  2BH3 A;  2HOW A;  3D27 A;  2BWY A;  2Q8K A;  2B3K A;  4JUQ A;  1WBQ A;  1YJ3 A;  4U69 A;  1BN5 A;  1XGM A;  3CB6 A;  3IU7 A;  4ZNG A;  3IU9 A;  2BWX A;  2BHB A;  2GA2 A;  1R5G A;  2GZ5 A;  2OKN A;  2GU6 A;  3MX6 A;  1A16 A;  1B6A A;  1QXY A;  2P99 A;  4PV4 A;  4IKU A;  2BWV A;  5CLS A;  5JFR A;  3L7G A;  4RZZ A;  1WN1 A;  4HXX A;  3FMQ A;  4U6Z A;  4B28 A;  3TB5 A;  4FLJ A;  4KM3 A;  2DFI A;  2GG0 A;  3IG4 A;  3BIQ A;  1R5H A;  4FLL A;  1XGO A;  4QR8 A;  4RGZ 1;  5JI6 A;  3CB5 A;  4Z7M A;  2GG2 A;  5CDL A;  2GG7 A;  5D6F A;  3L24 A;  4U1B A;  4U6W A;  4U75 A;  5E5B A;  2BWT A;  4IF7 A;  2GG5 A;  3MAT A;  3PKC A;  4U71 A;  4U76 A;  5CNX A;  3BIT A;  1YVM A;  2P9A A;  2IW2 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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