2GG8A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 88
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg8A00
4QR8A 4U70A 2NQ7A 2EVOA 3IG4A 2BWTA 4FKCA 4U69A 3PKEA 1C22A 4S2RP 5CE6A 2GG9A 3BIQA 1WKMA 3CB6A 4FO7A 4ZWPA 3MATA 4HXXA 3TB5A 3IU8A 2GGCA 5JHUA 1XGNA 2P9AA 4U6EA 3BITA 1A16A 3BIPA 3PKAA 4RGZ1 1MATA 5CDLA 1WBQA 2DFIA 3FMQA 4U71A 1O0XA 1R58A 4FLLA 4JUQA 1R5GA 4EGEA 1WLRA 2Q95A 1WY2A 3Q6DA 2Q8KA 2BB7A 4IECA 2OAZA 5JI6A 1KP0A 1Y1NA 1YVMA 3S6BA 2GG0A 4IU6A 2ZSGA 3PKDA 3MX6A 2IW2A 4IKTA 1KQ9A 1WN1A 4S00A 5D6FA 4ZWOA 2BWSA 1CHMA 2GG3A 2GTXA 4RZYA 1QZYA 2BN7A 1W2MA 2V6CA 2V3ZA 3D27A 4IKSA 1QXZA 3CTZA 3IU7A 3FMRA 2GU6A 2EVCA 4IPAA 4A6VA 1B59A 4U1BA 1QXWA 1JAWA 1C27A 4FLKA 4FO8A 2BWVA 4RZZA 3IU9A 2Q92A 1QXYA 1YJ3A 4U6JA 4R60A 2ADUA 3L7GA 4IKUA 4U75A 2OKNA 4FLJA 2BWYA 2GA2A 5CDEA 2BHDA 4IF7A 1YW8A 1B6AA 3TAVA 1XNZA 2HOWA 4PV4A 2GU5A 2P99A 2P98A 4FLIA 2GU4A 4KM3A 1KQ0A 1N51A 4IKRA 2BHBA 5D6EA 2G6PA 5JFRA 4MATA 3CB5A 4S01A 1BN5A 4PNCA 4U76A 5FCFA 4A6WA 2V3XA 4U73A 2MATA 5CIKA 2BWXA 3PKCA 2B3HA 4U6WA 3FM3A 1C21A 2Q94A 2EA2A 1W7VA 5E5BA 2BWWA 2GU7A 1M35A 1WL6A 3RORA 5FCHA 1PV9A 1XGOA 2V3YA 4ZWUA 1C23A 4Z7MA 4FUKA 2NQ6A 2GG7A 4U6ZA 4ZNGA 1YW7A 1BOAA 2B3KA 1R5HA 4U6CA 4S2TP 2GG8A 2BHAA 1C24A 2BH3A 1YW9A 4OOKA 1XGSA 4B28A 2GG2A 2BWUA 3RVAA 2GZ5A 2EVMA 3MR1A 5CDVA 4IDYA 1WL9A 2Q93A 2EA4A 2Q96A 3L24A 3PKBA 2GGBA 5CLSA 5CNXA 2GG5A 2BHCA 1XGMA 2B3LA
chains in the Genus database with same CATH superfamily
4QR8A 4U70A 2NQ7A 2EVOA 3IG4A 2BWTA 4FKCA 4U69A 3PKEA 1C22A 4S2RP 5CE6A 2GG9A 3BIQA 1WKMA 3CB6A 4FO7A 4ZWPA 3MATA 4HXXA 3TB5A 3IU8A 2GGCA 5JHUA 1XGNA 2P9AA 4U6EA 3BITA 1A16A 3BIPA 3PKAA 4RGZ1 1MATA 5CDLA 1WBQA 2DFIA 3FMQA 4U71A 1O0XA 1R58A 4FLLA 4JUQA 1R5GA 4EGEA 1WLRA 2Q95A 1WY2A 3Q6DA 2Q8KA 2BB7A 4IECA 2OAZA 5JI6A 1KP0A 1Y1NA 1YVMA 3S6BA 2GG0A 4IU6A 2ZSGA 3PKDA 3MX6A 2IW2A 4IKTA 1KQ9A 1WN1A 4S00A 5D6FA 4ZWOA 2BWSA 1CHMA 2GG3A 2GTXA 4RZYA 1QZYA 2BN7A 1W2MA 2V6CA 2V3ZA 3D27A 4IKSA 1QXZA 3CTZA 3IU7A 3FMRA 2GU6A 2EVCA 4IPAA 4A6VA 1B59A 4U1BA 1QXWA 1JAWA 1C27A 4FLKA 4FO8A 2BWVA 4RZZA 3IU9A 2Q92A 1QXYA 1YJ3A 4U6JA 4R60A 2ADUA 3L7GA 4IKUA 4U75A 2OKNA 4FLJA 2BWYA 2GA2A 5CDEA 2BHDA 4IF7A 1YW8A 1B6AA 3TAVA 1XNZA 2HOWA 4PV4A 2GU5A 2P99A 2P98A 4FLIA 2GU4A 4KM3A 1KQ0A 1N51A 4IKRA 2BHBA 5D6EA 2G6PA 5JFRA 4MATA 3CB5A 4S01A 1BN5A 4PNCA 4U76A 5FCFA 4A6WA 2V3XA 4U73A 2MATA 5CIKA 2BWXA 3PKCA 2B3HA 4U6WA 3FM3A 1C21A 2Q94A 2EA2A 1W7VA 5E5BA 2BWWA 2GU7A 1M35A 1WL6A 3RORA 5FCHA 1PV9A 1XGOA 2V3YA 4ZWUA 1C23A 4Z7MA 4FUKA 2NQ6A 2GG7A 4U6ZA 4ZNGA 1YW7A 1BOAA 2B3KA 1R5HA 4U6CA 4S2TP 2GG8A 2BHAA 1C24A 2BH3A 1YW9A 4OOKA 1XGSA 4B28A 2GG2A 2BWUA 3RVAA 2GZ5A 2EVMA 3MR1A 5CDVA 4IDYA 1WL9A 2Q93A 2EA4A 2Q96A 3L24A 3PKBA 2GGBA 5CLSA 5CNXA 2GG5A 2BHCA 1XGMA 2B3LA
chains in the Genus database with same CATH topology
4QR8A 4U70A 2NQ7A 2EVOA 3IG4A 2BWTA 4FKCA 4U69A 3PKEA 1C22A 4S2RP 5CE6A 2GG9A 3BIQA 1WKMA 3CB6A 4FO7A 4ZWPA 3MATA 4HXXA 3TB5A 3IU8A 2GGCA 5JHUA 1XGNA 2P9AA 4U6EA 3BITA 1A16A 3BIPA 3PKAA 4RGZ1 1MATA 5CDLA 1WBQA 2DFIA 3FMQA 4U71A 1O0XA 1R58A 4FLLA 4JUQA 1R5GA 4EGEA 1WLRA 2Q95A 1WY2A 3Q6DA 2Q8KA 2BB7A 4IECA 2OAZA 5JI6A 1KP0A 1Y1NA 1YVMA 3S6BA 2GG0A 4IU6A 2ZSGA 3PKDA 3MX6A 2IW2A 4IKTA 1KQ9A 1WN1A 4S00A 5D6FA 4ZWOA 2BWSA 1CHMA 2GG3A 2GTXA 4RZYA 1QZYA 2BN7A 1W2MA 2V6CA 2V3ZA 3D27A 4IKSA 1QXZA 3CTZA 3IU7A 3FMRA 2GU6A 2EVCA 4IPAA 4A6VA 1B59A 4U1BA 1QXWA 1JAWA 1C27A 4FLKA 4FO8A 2BWVA 4RZZA 3IU9A 2Q92A 1QXYA 1YJ3A 4U6JA 4R60A 2ADUA 3L7GA 4IKUA 4U75A 2OKNA 4FLJA 2BWYA 2GA2A 5CDEA 2BHDA 4IF7A 1YW8A 1B6AA 3TAVA 1XNZA 2HOWA 4PV4A 2GU5A 2P99A 2P98A 4FLIA 2GU4A 4KM3A 1KQ0A 1N51A 4IKRA 2BHBA 5D6EA 2G6PA 5JFRA 4MATA 3CB5A 4S01A 1BN5A 4PNCA 4U76A 5FCFA 4A6WA 2V3XA 4U73A 2MATA 5CIKA 2BWXA 3PKCA 2B3HA 4U6WA 3FM3A 1C21A 2Q94A 2EA2A 1W7VA 5E5BA 2BWWA 2GU7A 1M35A 1WL6A 3RORA 5FCHA 1PV9A 1XGOA 2V3YA 4ZWUA 1C23A 4Z7MA 4FUKA 2NQ6A 2GG7A 4U6ZA 4ZNGA 1YW7A 1BOAA 2B3KA 1R5HA 4U6CA 4S2TP 2GG8A 2BHAA 1C24A 2BH3A 1YW9A 4OOKA 1XGSA 4B28A 2GG2A 2BWUA 3RVAA 2GZ5A 2EVMA 3MR1A 5CDVA 4IDYA 1WL9A 2Q93A 2EA4A 2Q96A 3L24A 3PKBA 2GGBA 5CLSA 5CNXA 2GG5A 2BHCA 1XGMA 2B3LA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QR8 A;  4U70 A;  2NQ7 A;  2EVO A;  3IG4 A;  2BWT A;  4FKC A;  4U69 A;  3PKE A;  1C22 A;  4S2R P;  5CE6 A;  2GG9 A;  3BIQ A;  1WKM A;  3CB6 A;  4FO7 A;  4ZWP A;  3MAT A;  4HXX A;  3TB5 A;  3IU8 A;  2GGC A;  5JHU A;  1XGN A;  2P9A A;  4U6E A;  3BIT A;  1A16 A;  3BIP A;  3PKA A;  4RGZ 1;  1MAT A;  5CDL A;  1WBQ A;  2DFI A;  3FMQ A;  4U71 A;  1O0X A;  1R58 A;  4FLL A;  4JUQ A;  1R5G A;  4EGE A;  1WLR A;  2Q95 A;  1WY2 A;  3Q6D A;  2Q8K A;  2BB7 A;  4IEC A;  2OAZ A;  5JI6 A;  1KP0 A;  1Y1N A;  1YVM A;  3S6B A;  2GG0 A;  4IU6 A;  2ZSG A;  3PKD A;  3MX6 A;  2IW2 A;  4IKT A;  1KQ9 A;  1WN1 A;  4S00 A;  5D6F A;  4ZWO A;  2BWS A;  1CHM A;  2GG3 A;  2GTX A;  4RZY A;  1QZY A;  2BN7 A;  1W2M A;  2V6C A;  2V3Z A;  3D27 A;  4IKS A;  1QXZ A;  3CTZ A;  3IU7 A;  3FMR A;  2GU6 A;  2EVC A;  4IPA A;  4A6V A;  1B59 A;  4U1B A;  1QXW A;  1JAW A;  1C27 A;  4FLK A;  4FO8 A;  2BWV A;  4RZZ A;  3IU9 A;  2Q92 A;  1QXY A;  1YJ3 A;  4U6J A;  4R60 A;  2ADU A;  3L7G A;  4IKU A;  4U75 A;  2OKN A;  4FLJ A;  2BWY A;  2GA2 A;  5CDE A;  2BHD A;  4IF7 A;  1YW8 A;  1B6A A;  3TAV A;  1XNZ A;  2HOW A;  4PV4 A;  2GU5 A;  2P99 A;  2P98 A;  4FLI A;  2GU4 A;  4KM3 A;  1KQ0 A;  1N51 A;  4IKR A;  2BHB A;  5D6E A;  2G6P A;  5JFR A;  4MAT A;  3CB5 A;  4S01 A;  1BN5 A;  4PNC A;  4U76 A;  5FCF A;  4A6W A;  2V3X A;  4U73 A;  2MAT A;  5CIK A;  2BWX A;  3PKC A;  2B3H A;  4U6W A;  3FM3 A;  1C21 A;  2Q94 A;  2EA2 A;  1W7V A;  5E5B A;  2BWW A;  2GU7 A;  1M35 A;  1WL6 A;  3ROR A;  5FCH A;  1PV9 A;  1XGO A;  2V3Y A;  4ZWU A;  1C23 A;  4Z7M A;  4FUK A;  2NQ6 A;  2GG7 A;  4U6Z A;  4ZNG A;  1YW7 A;  1BOA A;  2B3K A;  1R5H A;  4U6C A;  4S2T P;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1YW9 A;  4OOK A;  1XGS A;  4B28 A;  2GG2 A;  2BWU A;  3RVA A;  2GZ5 A;  2EVM A;  3MR1 A;  5CDV A;  4IDY A;  1WL9 A;  2Q93 A;  2EA4 A;  2Q96 A;  3L24 A;  3PKB A;  2GGB A;  5CLS A;  5CNX A;  2GG5 A;  2BHC A;  1XGM A;  2B3L A; 
#chains in the Genus database with same CATH topology
 4QR8 A;  4U70 A;  2NQ7 A;  2EVO A;  3IG4 A;  2BWT A;  4FKC A;  4U69 A;  3PKE A;  1C22 A;  4S2R P;  5CE6 A;  2GG9 A;  3BIQ A;  1WKM A;  3CB6 A;  4FO7 A;  4ZWP A;  3MAT A;  4HXX A;  3TB5 A;  3IU8 A;  2GGC A;  5JHU A;  1XGN A;  2P9A A;  4U6E A;  3BIT A;  1A16 A;  3BIP A;  3PKA A;  4RGZ 1;  1MAT A;  5CDL A;  1WBQ A;  2DFI A;  3FMQ A;  4U71 A;  1O0X A;  1R58 A;  4FLL A;  4JUQ A;  1R5G A;  4EGE A;  1WLR A;  2Q95 A;  1WY2 A;  3Q6D A;  2Q8K A;  2BB7 A;  4IEC A;  2OAZ A;  5JI6 A;  1KP0 A;  1Y1N A;  1YVM A;  3S6B A;  2GG0 A;  4IU6 A;  2ZSG A;  3PKD A;  3MX6 A;  2IW2 A;  4IKT A;  1KQ9 A;  1WN1 A;  4S00 A;  5D6F A;  4ZWO A;  2BWS A;  1CHM A;  2GG3 A;  2GTX A;  4RZY A;  1QZY A;  2BN7 A;  1W2M A;  2V6C A;  2V3Z A;  3D27 A;  4IKS A;  1QXZ A;  3CTZ A;  3IU7 A;  3FMR A;  2GU6 A;  2EVC A;  4IPA A;  4A6V A;  1B59 A;  4U1B A;  1QXW A;  1JAW A;  1C27 A;  4FLK A;  4FO8 A;  2BWV A;  4RZZ A;  3IU9 A;  2Q92 A;  1QXY A;  1YJ3 A;  4U6J A;  4R60 A;  2ADU A;  3L7G A;  4IKU A;  4U75 A;  2OKN A;  4FLJ A;  2BWY A;  2GA2 A;  5CDE A;  2BHD A;  4IF7 A;  1YW8 A;  1B6A A;  3TAV A;  1XNZ A;  2HOW A;  4PV4 A;  2GU5 A;  2P99 A;  2P98 A;  4FLI A;  2GU4 A;  4KM3 A;  1KQ0 A;  1N51 A;  4IKR A;  2BHB A;  5D6E A;  2G6P A;  5JFR A;  4MAT A;  3CB5 A;  4S01 A;  1BN5 A;  4PNC A;  4U76 A;  5FCF A;  4A6W A;  2V3X A;  4U73 A;  2MAT A;  5CIK A;  2BWX A;  3PKC A;  2B3H A;  4U6W A;  3FM3 A;  1C21 A;  2Q94 A;  2EA2 A;  1W7V A;  5E5B A;  2BWW A;  2GU7 A;  1M35 A;  1WL6 A;  3ROR A;  5FCH A;  1PV9 A;  1XGO A;  2V3Y A;  4ZWU A;  1C23 A;  4Z7M A;  4FUK A;  2NQ6 A;  2GG7 A;  4U6Z A;  4ZNG A;  1YW7 A;  1BOA A;  2B3K A;  1R5H A;  4U6C A;  4S2T P;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1YW9 A;  4OOK A;  1XGS A;  4B28 A;  2GG2 A;  2BWU A;  3RVA A;  2GZ5 A;  2EVM A;  3MR1 A;  5CDV A;  4IDY A;  1WL9 A;  2Q93 A;  2EA4 A;  2Q96 A;  3L24 A;  3PKB A;  2GGB A;  5CLS A;  5CNX A;  2GG5 A;  2BHC A;  1XGM A;  2B3L A; 
#chains in the Genus database with same CATH homology
 4QR8 A;  4U70 A;  2NQ7 A;  2EVO A;  3IG4 A;  2BWT A;  4FKC A;  4U69 A;  3PKE A;  1C22 A;  4S2R P;  5CE6 A;  2GG9 A;  3BIQ A;  1WKM A;  3CB6 A;  4FO7 A;  4ZWP A;  3MAT A;  4HXX A;  3TB5 A;  3IU8 A;  2GGC A;  5JHU A;  1XGN A;  2P9A A;  4U6E A;  3BIT A;  1A16 A;  3BIP A;  3PKA A;  4RGZ 1;  1MAT A;  5CDL A;  1WBQ A;  2DFI A;  3FMQ A;  4U71 A;  1O0X A;  1R58 A;  4FLL A;  4JUQ A;  1R5G A;  4EGE A;  1WLR A;  2Q95 A;  1WY2 A;  3Q6D A;  2Q8K A;  2BB7 A;  4IEC A;  2OAZ A;  5JI6 A;  1KP0 A;  1Y1N A;  1YVM A;  3S6B A;  2GG0 A;  4IU6 A;  2ZSG A;  3PKD A;  3MX6 A;  2IW2 A;  4IKT A;  1KQ9 A;  1WN1 A;  4S00 A;  5D6F A;  4ZWO A;  2BWS A;  1CHM A;  2GG3 A;  2GTX A;  4RZY A;  1QZY A;  2BN7 A;  1W2M A;  2V6C A;  2V3Z A;  3D27 A;  4IKS A;  1QXZ A;  3CTZ A;  3IU7 A;  3FMR A;  2GU6 A;  2EVC A;  4IPA A;  4A6V A;  1B59 A;  4U1B A;  1QXW A;  1JAW A;  1C27 A;  4FLK A;  4FO8 A;  2BWV A;  4RZZ A;  3IU9 A;  2Q92 A;  1QXY A;  1YJ3 A;  4U6J A;  4R60 A;  2ADU A;  3L7G A;  4IKU A;  4U75 A;  2OKN A;  4FLJ A;  2BWY A;  2GA2 A;  5CDE A;  2BHD A;  4IF7 A;  1YW8 A;  1B6A A;  3TAV A;  1XNZ A;  2HOW A;  4PV4 A;  2GU5 A;  2P99 A;  2P98 A;  4FLI A;  2GU4 A;  4KM3 A;  1KQ0 A;  1N51 A;  4IKR A;  2BHB A;  5D6E A;  2G6P A;  5JFR A;  4MAT A;  3CB5 A;  4S01 A;  1BN5 A;  4PNC A;  4U76 A;  5FCF A;  4A6W A;  2V3X A;  4U73 A;  2MAT A;  5CIK A;  2BWX A;  3PKC A;  2B3H A;  4U6W A;  3FM3 A;  1C21 A;  2Q94 A;  2EA2 A;  1W7V A;  5E5B A;  2BWW A;  2GU7 A;  1M35 A;  1WL6 A;  3ROR A;  5FCH A;  1PV9 A;  1XGO A;  2V3Y A;  4ZWU A;  1C23 A;  4Z7M A;  4FUK A;  2NQ6 A;  2GG7 A;  4U6Z A;  4ZNG A;  1YW7 A;  1BOA A;  2B3K A;  1R5H A;  4U6C A;  4S2T P;  2GG8 A;  2BHA A;  1C24 A;  2BH3 A;  1YW9 A;  4OOK A;  1XGS A;  4B28 A;  2GG2 A;  2BWU A;  3RVA A;  2GZ5 A;  2EVM A;  3MR1 A;  5CDV A;  4IDY A;  1WL9 A;  2Q93 A;  2EA4 A;  2Q96 A;  3L24 A;  3PKB A;  2GGB A;  5CLS A;  5CNX A;  2GG5 A;  2BHC A;  1XGM A;  2B3L A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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