2GG9A

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 86
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gg9A00
4S2TP 4U70A 3TB5A 4FKCA 3PKDA 2BWXA 1QZYA 1XGMA 2GG0A 4FLJA 3Q6DA 2Q93A 4U6WA 2BWVA 1YW7A 4U69A 1YW9A 2ADUA 4IKTA 5CDVA 4IF7A 2EVOA 1O0XA 5CE6A 2GG3A 3MATA 4HXXA 1A16A 2Q94A 3RORA 3MX6A 3FM3A 1YW8A 1N51A 3L24A 1C23A 3BIPA 1XGNA 1QXWA 3IU7A 4IKRA 1WN1A 5CIKA 2V3YA 1W7VA 2DFIA 2ZSGA 3FMQA 5JI6A 2GGCA 3CB5A 4B28A 1XGSA 4U6JA 4S01A 2P99A 4FLIA 4FO7A 2GG7A 2BWUA 2GU7A 3FMRA 1JAWA 5JFRA 4A6WA 2GGBA 2IW2A 2EA4A 1WBQA 3S6BA 1R5HA 2OKNA 2BWTA 4FLKA 4A6VA 5FCHA 2BN7A 2V6CA 1Y1NA 2EVCA 3BITA 1M35A 4FO8A 5E5BA 3PKEA 5D6FA 5FCFA 2BB7A 4IDYA 3IU9A 1BOAA 2EVMA 2MATA 2Q92A 2P9AA 1C21A 4IKSA 4ZWUA 3L7GA 4R60A 3PKAA 2V3XA 2B3LA 2OAZA 1WKMA 4IPAA 3PKCA 1B6AA 1WL9A 4U6CA 4ZWOA 4OOKA 4PNCA 1R58A 1QXYA 2GG2A 2Q95A 2BH3A 3IU8A 4U6ZA 4ZNGA 2V3ZA 5CDLA 3CB6A 2GTXA 3BIQA 1CHMA 2GZ5A 1C24A 3D27A 3MR1A 1WLRA 2BHAA 1YJ3A 2NQ6A 2BHDA 1KQ0A 5JHUA 1C22A 4IECA 4KM3A 4U1BA 2BHBA 5CLSA 2BWYA 2BHCA 2GG8A 4S2RP 2GA2A 3IG4A 3PKBA 1KP0A 2Q96A 3TAVA 4FLLA 4S00A 5CDEA 3RVAA 2GU6A 4U6EA 4U71A 2BWWA 4JUQA 1B59A 2GU4A 1W2MA 4EGEA 4U73A 5CNXA 4QR8A 2GG5A 2P98A 2GG9A 4FUKA 1XNZA 1R5GA 1BN5A 4IU6A 1MATA 2Q8KA 1KQ9A 2GU5A 4ZWPA 4RZYA 4MATA 2EA2A 1WY2A 3CTZA 4RZZA 4PV4A 4U76A 2NQ7A 4U75A 2BWSA 5D6EA 1PV9A 1C27A 4RGZ1 2HOWA 4IKUA 1XGOA 2B3KA 1YVMA 4Z7MA 1QXZA 1WL6A 2G6PA 2B3HA
chains in the Genus database with same CATH superfamily
4S2TP 4U70A 3TB5A 4FKCA 3PKDA 2BWXA 1QZYA 1XGMA 2GG0A 4FLJA 3Q6DA 2Q93A 4U6WA 2BWVA 1YW7A 4U69A 1YW9A 2ADUA 4IKTA 5CDVA 4IF7A 2EVOA 1O0XA 5CE6A 2GG3A 3MATA 4HXXA 1A16A 2Q94A 3RORA 3MX6A 3FM3A 1YW8A 1N51A 3L24A 1C23A 3BIPA 1XGNA 1QXWA 3IU7A 4IKRA 1WN1A 5CIKA 2V3YA 1W7VA 2DFIA 2ZSGA 3FMQA 5JI6A 2GGCA 3CB5A 4B28A 1XGSA 4U6JA 4S01A 2P99A 4FLIA 4FO7A 2GG7A 2BWUA 2GU7A 3FMRA 1JAWA 5JFRA 4A6WA 2GGBA 2IW2A 2EA4A 1WBQA 3S6BA 1R5HA 2OKNA 2BWTA 4FLKA 4A6VA 5FCHA 2BN7A 2V6CA 1Y1NA 2EVCA 3BITA 1M35A 4FO8A 5E5BA 3PKEA 5D6FA 5FCFA 2BB7A 4IDYA 3IU9A 1BOAA 2EVMA 2MATA 2Q92A 2P9AA 1C21A 4IKSA 4ZWUA 3L7GA 4R60A 3PKAA 2V3XA 2B3LA 2OAZA 1WKMA 4IPAA 3PKCA 1B6AA 1WL9A 4U6CA 4ZWOA 4OOKA 4PNCA 1R58A 1QXYA 2GG2A 2Q95A 2BH3A 3IU8A 4U6ZA 4ZNGA 2V3ZA 5CDLA 3CB6A 2GTXA 3BIQA 1CHMA 2GZ5A 1C24A 3D27A 3MR1A 1WLRA 2BHAA 1YJ3A 2NQ6A 2BHDA 1KQ0A 5JHUA 1C22A 4IECA 4KM3A 4U1BA 2BHBA 5CLSA 2BWYA 2BHCA 2GG8A 4S2RP 2GA2A 3IG4A 3PKBA 1KP0A 2Q96A 3TAVA 4FLLA 4S00A 5CDEA 3RVAA 2GU6A 4U6EA 4U71A 2BWWA 4JUQA 1B59A 2GU4A 1W2MA 4EGEA 4U73A 5CNXA 4QR8A 2GG5A 2P98A 2GG9A 4FUKA 1XNZA 1R5GA 1BN5A 4IU6A 1MATA 2Q8KA 1KQ9A 2GU5A 4ZWPA 4RZYA 4MATA 2EA2A 1WY2A 3CTZA 4RZZA 4PV4A 4U76A 2NQ7A 4U75A 2BWSA 5D6EA 1PV9A 1C27A 4RGZ1 2HOWA 4IKUA 1XGOA 2B3KA 1YVMA 4Z7MA 1QXZA 1WL6A 2G6PA 2B3HA
chains in the Genus database with same CATH topology
4S2TP 4U70A 3TB5A 4FKCA 3PKDA 2BWXA 1QZYA 1XGMA 2GG0A 4FLJA 3Q6DA 2Q93A 4U6WA 2BWVA 1YW7A 4U69A 1YW9A 2ADUA 4IKTA 5CDVA 4IF7A 2EVOA 1O0XA 5CE6A 2GG3A 3MATA 4HXXA 1A16A 2Q94A 3RORA 3MX6A 3FM3A 1YW8A 1N51A 3L24A 1C23A 3BIPA 1XGNA 1QXWA 3IU7A 4IKRA 1WN1A 5CIKA 2V3YA 1W7VA 2DFIA 2ZSGA 3FMQA 5JI6A 2GGCA 3CB5A 4B28A 1XGSA 4U6JA 4S01A 2P99A 4FLIA 4FO7A 2GG7A 2BWUA 2GU7A 3FMRA 1JAWA 5JFRA 4A6WA 2GGBA 2IW2A 2EA4A 1WBQA 3S6BA 1R5HA 2OKNA 2BWTA 4FLKA 4A6VA 5FCHA 2BN7A 2V6CA 1Y1NA 2EVCA 3BITA 1M35A 4FO8A 5E5BA 3PKEA 5D6FA 5FCFA 2BB7A 4IDYA 3IU9A 1BOAA 2EVMA 2MATA 2Q92A 2P9AA 1C21A 4IKSA 4ZWUA 3L7GA 4R60A 3PKAA 2V3XA 2B3LA 2OAZA 1WKMA 4IPAA 3PKCA 1B6AA 1WL9A 4U6CA 4ZWOA 4OOKA 4PNCA 1R58A 1QXYA 2GG2A 2Q95A 2BH3A 3IU8A 4U6ZA 4ZNGA 2V3ZA 5CDLA 3CB6A 2GTXA 3BIQA 1CHMA 2GZ5A 1C24A 3D27A 3MR1A 1WLRA 2BHAA 1YJ3A 2NQ6A 2BHDA 1KQ0A 5JHUA 1C22A 4IECA 4KM3A 4U1BA 2BHBA 5CLSA 2BWYA 2BHCA 2GG8A 4S2RP 2GA2A 3IG4A 3PKBA 1KP0A 2Q96A 3TAVA 4FLLA 4S00A 5CDEA 3RVAA 2GU6A 4U6EA 4U71A 2BWWA 4JUQA 1B59A 2GU4A 1W2MA 4EGEA 4U73A 5CNXA 4QR8A 2GG5A 2P98A 2GG9A 4FUKA 1XNZA 1R5GA 1BN5A 4IU6A 1MATA 2Q8KA 1KQ9A 2GU5A 4ZWPA 4RZYA 4MATA 2EA2A 1WY2A 3CTZA 4RZZA 4PV4A 4U76A 2NQ7A 4U75A 2BWSA 5D6EA 1PV9A 1C27A 4RGZ1 2HOWA 4IKUA 1XGOA 2B3KA 1YVMA 4Z7MA 1QXZA 1WL6A 2G6PA 2B3HA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4S2T P;  4U70 A;  3TB5 A;  4FKC A;  3PKD A;  2BWX A;  1QZY A;  1XGM A;  2GG0 A;  4FLJ A;  3Q6D A;  2Q93 A;  4U6W A;  2BWV A;  1YW7 A;  4U69 A;  1YW9 A;  2ADU A;  4IKT A;  5CDV A;  4IF7 A;  2EVO A;  1O0X A;  5CE6 A;  2GG3 A;  3MAT A;  4HXX A;  1A16 A;  2Q94 A;  3ROR A;  3MX6 A;  3FM3 A;  1YW8 A;  1N51 A;  3L24 A;  1C23 A;  3BIP A;  1XGN A;  1QXW A;  3IU7 A;  4IKR A;  1WN1 A;  5CIK A;  2V3Y A;  1W7V A;  2DFI A;  2ZSG A;  3FMQ A;  5JI6 A;  2GGC A;  3CB5 A;  4B28 A;  1XGS A;  4U6J A;  4S01 A;  2P99 A;  4FLI A;  4FO7 A;  2GG7 A;  2BWU A;  2GU7 A;  3FMR A;  1JAW A;  5JFR A;  4A6W A;  2GGB A;  2IW2 A;  2EA4 A;  1WBQ A;  3S6B A;  1R5H A;  2OKN A;  2BWT A;  4FLK A;  4A6V A;  5FCH A;  2BN7 A;  2V6C A;  1Y1N A;  2EVC A;  3BIT A;  1M35 A;  4FO8 A;  5E5B A;  3PKE A;  5D6F A;  5FCF A;  2BB7 A;  4IDY A;  3IU9 A;  1BOA A;  2EVM A;  2MAT A;  2Q92 A;  2P9A A;  1C21 A;  4IKS A;  4ZWU A;  3L7G A;  4R60 A;  3PKA A;  2V3X A;  2B3L A;  2OAZ A;  1WKM A;  4IPA A;  3PKC A;  1B6A A;  1WL9 A;  4U6C A;  4ZWO A;  4OOK A;  4PNC A;  1R58 A;  1QXY A;  2GG2 A;  2Q95 A;  2BH3 A;  3IU8 A;  4U6Z A;  4ZNG A;  2V3Z A;  5CDL A;  3CB6 A;  2GTX A;  3BIQ A;  1CHM A;  2GZ5 A;  1C24 A;  3D27 A;  3MR1 A;  1WLR A;  2BHA A;  1YJ3 A;  2NQ6 A;  2BHD A;  1KQ0 A;  5JHU A;  1C22 A;  4IEC A;  4KM3 A;  4U1B A;  2BHB A;  5CLS A;  2BWY A;  2BHC A;  2GG8 A;  4S2R P;  2GA2 A;  3IG4 A;  3PKB A;  1KP0 A;  2Q96 A;  3TAV A;  4FLL A;  4S00 A;  5CDE A;  3RVA A;  2GU6 A;  4U6E A;  4U71 A;  2BWW A;  4JUQ A;  1B59 A;  2GU4 A;  1W2M A;  4EGE A;  4U73 A;  5CNX A;  4QR8 A;  2GG5 A;  2P98 A;  2GG9 A;  4FUK A;  1XNZ A;  1R5G A;  1BN5 A;  4IU6 A;  1MAT A;  2Q8K A;  1KQ9 A;  2GU5 A;  4ZWP A;  4RZY A;  4MAT A;  2EA2 A;  1WY2 A;  3CTZ A;  4RZZ A;  4PV4 A;  4U76 A;  2NQ7 A;  4U75 A;  2BWS A;  5D6E A;  1PV9 A;  1C27 A;  4RGZ 1;  2HOW A;  4IKU A;  1XGO A;  2B3K A;  1YVM A;  4Z7M A;  1QXZ A;  1WL6 A;  2G6P A;  2B3H A; 
#chains in the Genus database with same CATH topology
 4S2T P;  4U70 A;  3TB5 A;  4FKC A;  3PKD A;  2BWX A;  1QZY A;  1XGM A;  2GG0 A;  4FLJ A;  3Q6D A;  2Q93 A;  4U6W A;  2BWV A;  1YW7 A;  4U69 A;  1YW9 A;  2ADU A;  4IKT A;  5CDV A;  4IF7 A;  2EVO A;  1O0X A;  5CE6 A;  2GG3 A;  3MAT A;  4HXX A;  1A16 A;  2Q94 A;  3ROR A;  3MX6 A;  3FM3 A;  1YW8 A;  1N51 A;  3L24 A;  1C23 A;  3BIP A;  1XGN A;  1QXW A;  3IU7 A;  4IKR A;  1WN1 A;  5CIK A;  2V3Y A;  1W7V A;  2DFI A;  2ZSG A;  3FMQ A;  5JI6 A;  2GGC A;  3CB5 A;  4B28 A;  1XGS A;  4U6J A;  4S01 A;  2P99 A;  4FLI A;  4FO7 A;  2GG7 A;  2BWU A;  2GU7 A;  3FMR A;  1JAW A;  5JFR A;  4A6W A;  2GGB A;  2IW2 A;  2EA4 A;  1WBQ A;  3S6B A;  1R5H A;  2OKN A;  2BWT A;  4FLK A;  4A6V A;  5FCH A;  2BN7 A;  2V6C A;  1Y1N A;  2EVC A;  3BIT A;  1M35 A;  4FO8 A;  5E5B A;  3PKE A;  5D6F A;  5FCF A;  2BB7 A;  4IDY A;  3IU9 A;  1BOA A;  2EVM A;  2MAT A;  2Q92 A;  2P9A A;  1C21 A;  4IKS A;  4ZWU A;  3L7G A;  4R60 A;  3PKA A;  2V3X A;  2B3L A;  2OAZ A;  1WKM A;  4IPA A;  3PKC A;  1B6A A;  1WL9 A;  4U6C A;  4ZWO A;  4OOK A;  4PNC A;  1R58 A;  1QXY A;  2GG2 A;  2Q95 A;  2BH3 A;  3IU8 A;  4U6Z A;  4ZNG A;  2V3Z A;  5CDL A;  3CB6 A;  2GTX A;  3BIQ A;  1CHM A;  2GZ5 A;  1C24 A;  3D27 A;  3MR1 A;  1WLR A;  2BHA A;  1YJ3 A;  2NQ6 A;  2BHD A;  1KQ0 A;  5JHU A;  1C22 A;  4IEC A;  4KM3 A;  4U1B A;  2BHB A;  5CLS A;  2BWY A;  2BHC A;  2GG8 A;  4S2R P;  2GA2 A;  3IG4 A;  3PKB A;  1KP0 A;  2Q96 A;  3TAV A;  4FLL A;  4S00 A;  5CDE A;  3RVA A;  2GU6 A;  4U6E A;  4U71 A;  2BWW A;  4JUQ A;  1B59 A;  2GU4 A;  1W2M A;  4EGE A;  4U73 A;  5CNX A;  4QR8 A;  2GG5 A;  2P98 A;  2GG9 A;  4FUK A;  1XNZ A;  1R5G A;  1BN5 A;  4IU6 A;  1MAT A;  2Q8K A;  1KQ9 A;  2GU5 A;  4ZWP A;  4RZY A;  4MAT A;  2EA2 A;  1WY2 A;  3CTZ A;  4RZZ A;  4PV4 A;  4U76 A;  2NQ7 A;  4U75 A;  2BWS A;  5D6E A;  1PV9 A;  1C27 A;  4RGZ 1;  2HOW A;  4IKU A;  1XGO A;  2B3K A;  1YVM A;  4Z7M A;  1QXZ A;  1WL6 A;  2G6P A;  2B3H A; 
#chains in the Genus database with same CATH homology
 4S2T P;  4U70 A;  3TB5 A;  4FKC A;  3PKD A;  2BWX A;  1QZY A;  1XGM A;  2GG0 A;  4FLJ A;  3Q6D A;  2Q93 A;  4U6W A;  2BWV A;  1YW7 A;  4U69 A;  1YW9 A;  2ADU A;  4IKT A;  5CDV A;  4IF7 A;  2EVO A;  1O0X A;  5CE6 A;  2GG3 A;  3MAT A;  4HXX A;  1A16 A;  2Q94 A;  3ROR A;  3MX6 A;  3FM3 A;  1YW8 A;  1N51 A;  3L24 A;  1C23 A;  3BIP A;  1XGN A;  1QXW A;  3IU7 A;  4IKR A;  1WN1 A;  5CIK A;  2V3Y A;  1W7V A;  2DFI A;  2ZSG A;  3FMQ A;  5JI6 A;  2GGC A;  3CB5 A;  4B28 A;  1XGS A;  4U6J A;  4S01 A;  2P99 A;  4FLI A;  4FO7 A;  2GG7 A;  2BWU A;  2GU7 A;  3FMR A;  1JAW A;  5JFR A;  4A6W A;  2GGB A;  2IW2 A;  2EA4 A;  1WBQ A;  3S6B A;  1R5H A;  2OKN A;  2BWT A;  4FLK A;  4A6V A;  5FCH A;  2BN7 A;  2V6C A;  1Y1N A;  2EVC A;  3BIT A;  1M35 A;  4FO8 A;  5E5B A;  3PKE A;  5D6F A;  5FCF A;  2BB7 A;  4IDY A;  3IU9 A;  1BOA A;  2EVM A;  2MAT A;  2Q92 A;  2P9A A;  1C21 A;  4IKS A;  4ZWU A;  3L7G A;  4R60 A;  3PKA A;  2V3X A;  2B3L A;  2OAZ A;  1WKM A;  4IPA A;  3PKC A;  1B6A A;  1WL9 A;  4U6C A;  4ZWO A;  4OOK A;  4PNC A;  1R58 A;  1QXY A;  2GG2 A;  2Q95 A;  2BH3 A;  3IU8 A;  4U6Z A;  4ZNG A;  2V3Z A;  5CDL A;  3CB6 A;  2GTX A;  3BIQ A;  1CHM A;  2GZ5 A;  1C24 A;  3D27 A;  3MR1 A;  1WLR A;  2BHA A;  1YJ3 A;  2NQ6 A;  2BHD A;  1KQ0 A;  5JHU A;  1C22 A;  4IEC A;  4KM3 A;  4U1B A;  2BHB A;  5CLS A;  2BWY A;  2BHC A;  2GG8 A;  4S2R P;  2GA2 A;  3IG4 A;  3PKB A;  1KP0 A;  2Q96 A;  3TAV A;  4FLL A;  4S00 A;  5CDE A;  3RVA A;  2GU6 A;  4U6E A;  4U71 A;  2BWW A;  4JUQ A;  1B59 A;  2GU4 A;  1W2M A;  4EGE A;  4U73 A;  5CNX A;  4QR8 A;  2GG5 A;  2P98 A;  2GG9 A;  4FUK A;  1XNZ A;  1R5G A;  1BN5 A;  4IU6 A;  1MAT A;  2Q8K A;  1KQ9 A;  2GU5 A;  4ZWP A;  4RZY A;  4MAT A;  2EA2 A;  1WY2 A;  3CTZ A;  4RZZ A;  4PV4 A;  4U76 A;  2NQ7 A;  4U75 A;  2BWS A;  5D6E A;  1PV9 A;  1C27 A;  4RGZ 1;  2HOW A;  4IKU A;  1XGO A;  2B3K A;  1YVM A;  4Z7M A;  1QXZ A;  1WL6 A;  2G6P A;  2B3H A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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