2GGBA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 84
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
84
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli k12
molecule keywords Methionine aminopeptidase
total genus 84
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggbA00
1CHMA 1YJ3A 1QXYA 4U6CA 2EVMA 1WY2A 2BHDA 2BWWA 2Q93A 2BWTA 4FO8A 3PKCA 4OOKA 5JI6A 4R60A 1QXZA 2GG8A 3IU9A 2ZSGA 2V3YA 1BN5A 1Y1NA 1XGOA 2BWUA 4ZWOA 1BOAA 2OKNA 4FUKA 2EVOA 2HOWA 4A6VA 4U76A 1C27A 1M35A 3FMQA 4FLKA 5JHUA 1C24A 3PKAA 3RVAA 2BB7A 5FCHA 4EGEA 2BWSA 2BN7A 3D27A 3MR1A 1YW8A 2DFIA 3PKEA 3TB5A 2Q92A 4S01A 1WN1A 1JAWA 1R5HA 5E5BA 3S6BA 3CB5A 3MX6A 4U69A 5CDLA 2NQ7A 4QR8A 1XNZA 3Q6DA 4U6WA 3PKDA 2GG7A 4IDYA 1QXWA 3PKBA 5D6EA 4U73A 1XGSA 4IF7A 1MATA 4ZNGA 4U71A 4IU6A 5CDEA 5FCFA 2B3KA 4IECA 2G6PA 2GG2A 4ZWPA 2EA2A 3BIPA 1N51A 1WKMA 1KP0A 3CTZA 1WLRA 2IW2A 1KQ0A 3FMRA 4PV4A 4RZZA 2ADUA 5D6FA 1C21A 1W7VA 4IKSA 4S00A 1O0XA 2V3ZA 4FKCA 1B59A 2GU5A 4IKUA 5CIKA 4U6ZA 2BHCA 3IG4A 1R5GA 2P98A 3TAVA 1C23A 5CDVA 1WL9A 4FLLA 4PNCA 2GU6A 2Q8KA 2B3HA 4ZWUA 2BWVA 3BIQA 4U75A 5CLSA 2GG5A 3FM3A 2GGBA 4A6WA 1YVMA 2BH3A 2OAZA 4RGZ1 4U1BA 4JUQA 2GA2A 3CB6A 2P9AA 1XGMA 5CE6A 1QZYA 2Q94A 2V3XA 4IKRA 1B6AA 2EA4A 2V6CA 5CNXA 4RZYA 2GU4A 3L7GA 2GU7A 2Q95A 3IU8A 4KM3A 2EVCA 4U6JA 2GZ5A 2BHBA 4IPAA 2P99A 2BWXA 3IU7A 4S2RP 1R58A 4HXXA 2B3LA 1W2MA 4MATA 1C22A 2GG3A 2GGCA 4FO7A 4U70A 3BITA 2GG9A 2NQ6A 4B28A 2MATA 1A16A 1WL6A 4S2TP 4FLIA 1XGNA 2BWYA 3L24A 1YW7A 1WBQA 2BHAA 2GG0A 2Q96A 4FLJA 1PV9A 2GTXA 3MATA 4Z7MA 4IKTA 5JFRA 1KQ9A 4U6EA 1YW9A 3RORA
chains in the Genus database with same CATH superfamily
1CHMA 1YJ3A 1QXYA 4U6CA 2EVMA 1WY2A 2BHDA 2BWWA 2Q93A 2BWTA 4FO8A 3PKCA 4OOKA 5JI6A 4R60A 1QXZA 2GG8A 3IU9A 2ZSGA 2V3YA 1BN5A 1Y1NA 1XGOA 2BWUA 4ZWOA 1BOAA 2OKNA 4FUKA 2EVOA 2HOWA 4A6VA 4U76A 1C27A 1M35A 3FMQA 4FLKA 5JHUA 1C24A 3PKAA 3RVAA 2BB7A 5FCHA 4EGEA 2BWSA 2BN7A 3D27A 3MR1A 1YW8A 2DFIA 3PKEA 3TB5A 2Q92A 4S01A 1WN1A 1JAWA 1R5HA 5E5BA 3S6BA 3CB5A 3MX6A 4U69A 5CDLA 2NQ7A 4QR8A 1XNZA 3Q6DA 4U6WA 3PKDA 2GG7A 4IDYA 1QXWA 3PKBA 5D6EA 4U73A 1XGSA 4IF7A 1MATA 4ZNGA 4U71A 4IU6A 5CDEA 5FCFA 2B3KA 4IECA 2G6PA 2GG2A 4ZWPA 2EA2A 3BIPA 1N51A 1WKMA 1KP0A 3CTZA 1WLRA 2IW2A 1KQ0A 3FMRA 4PV4A 4RZZA 2ADUA 5D6FA 1C21A 1W7VA 4IKSA 4S00A 1O0XA 2V3ZA 4FKCA 1B59A 2GU5A 4IKUA 5CIKA 4U6ZA 2BHCA 3IG4A 1R5GA 2P98A 3TAVA 1C23A 5CDVA 1WL9A 4FLLA 4PNCA 2GU6A 2Q8KA 2B3HA 4ZWUA 2BWVA 3BIQA 4U75A 5CLSA 2GG5A 3FM3A 2GGBA 4A6WA 1YVMA 2BH3A 2OAZA 4RGZ1 4U1BA 4JUQA 2GA2A 3CB6A 2P9AA 1XGMA 5CE6A 1QZYA 2Q94A 2V3XA 4IKRA 1B6AA 2EA4A 2V6CA 5CNXA 4RZYA 2GU4A 3L7GA 2GU7A 2Q95A 3IU8A 4KM3A 2EVCA 4U6JA 2GZ5A 2BHBA 4IPAA 2P99A 2BWXA 3IU7A 4S2RP 1R58A 4HXXA 2B3LA 1W2MA 4MATA 1C22A 2GG3A 2GGCA 4FO7A 4U70A 3BITA 2GG9A 2NQ6A 4B28A 2MATA 1A16A 1WL6A 4S2TP 4FLIA 1XGNA 2BWYA 3L24A 1YW7A 1WBQA 2BHAA 2GG0A 2Q96A 4FLJA 1PV9A 2GTXA 3MATA 4Z7MA 4IKTA 5JFRA 1KQ9A 4U6EA 1YW9A 3RORA
chains in the Genus database with same CATH topology
1CHMA 1YJ3A 1QXYA 4U6CA 2EVMA 1WY2A 2BHDA 2BWWA 2Q93A 2BWTA 4FO8A 3PKCA 4OOKA 5JI6A 4R60A 1QXZA 2GG8A 3IU9A 2ZSGA 2V3YA 1BN5A 1Y1NA 1XGOA 2BWUA 4ZWOA 1BOAA 2OKNA 4FUKA 2EVOA 2HOWA 4A6VA 4U76A 1C27A 1M35A 3FMQA 4FLKA 5JHUA 1C24A 3PKAA 3RVAA 2BB7A 5FCHA 4EGEA 2BWSA 2BN7A 3D27A 3MR1A 1YW8A 2DFIA 3PKEA 3TB5A 2Q92A 4S01A 1WN1A 1JAWA 1R5HA 5E5BA 3S6BA 3CB5A 3MX6A 4U69A 5CDLA 2NQ7A 4QR8A 1XNZA 3Q6DA 4U6WA 3PKDA 2GG7A 4IDYA 1QXWA 3PKBA 5D6EA 4U73A 1XGSA 4IF7A 1MATA 4ZNGA 4U71A 4IU6A 5CDEA 5FCFA 2B3KA 4IECA 2G6PA 2GG2A 4ZWPA 2EA2A 3BIPA 1N51A 1WKMA 1KP0A 3CTZA 1WLRA 2IW2A 1KQ0A 3FMRA 4PV4A 4RZZA 2ADUA 5D6FA 1C21A 1W7VA 4IKSA 4S00A 1O0XA 2V3ZA 4FKCA 1B59A 2GU5A 4IKUA 5CIKA 4U6ZA 2BHCA 3IG4A 1R5GA 2P98A 3TAVA 1C23A 5CDVA 1WL9A 4FLLA 4PNCA 2GU6A 2Q8KA 2B3HA 4ZWUA 2BWVA 3BIQA 4U75A 5CLSA 2GG5A 3FM3A 2GGBA 4A6WA 1YVMA 2BH3A 2OAZA 4RGZ1 4U1BA 4JUQA 2GA2A 3CB6A 2P9AA 1XGMA 5CE6A 1QZYA 2Q94A 2V3XA 4IKRA 1B6AA 2EA4A 2V6CA 5CNXA 4RZYA 2GU4A 3L7GA 2GU7A 2Q95A 3IU8A 4KM3A 2EVCA 4U6JA 2GZ5A 2BHBA 4IPAA 2P99A 2BWXA 3IU7A 4S2RP 1R58A 4HXXA 2B3LA 1W2MA 4MATA 1C22A 2GG3A 2GGCA 4FO7A 4U70A 3BITA 2GG9A 2NQ6A 4B28A 2MATA 1A16A 1WL6A 4S2TP 4FLIA 1XGNA 2BWYA 3L24A 1YW7A 1WBQA 2BHAA 2GG0A 2Q96A 4FLJA 1PV9A 2GTXA 3MATA 4Z7MA 4IKTA 5JFRA 1KQ9A 4U6EA 1YW9A 3RORA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1CHM A;  1YJ3 A;  1QXY A;  4U6C A;  2EVM A;  1WY2 A;  2BHD A;  2BWW A;  2Q93 A;  2BWT A;  4FO8 A;  3PKC A;  4OOK A;  5JI6 A;  4R60 A;  1QXZ A;  2GG8 A;  3IU9 A;  2ZSG A;  2V3Y A;  1BN5 A;  1Y1N A;  1XGO A;  2BWU A;  4ZWO A;  1BOA A;  2OKN A;  4FUK A;  2EVO A;  2HOW A;  4A6V A;  4U76 A;  1C27 A;  1M35 A;  3FMQ A;  4FLK A;  5JHU A;  1C24 A;  3PKA A;  3RVA A;  2BB7 A;  5FCH A;  4EGE A;  2BWS A;  2BN7 A;  3D27 A;  3MR1 A;  1YW8 A;  2DFI A;  3PKE A;  3TB5 A;  2Q92 A;  4S01 A;  1WN1 A;  1JAW A;  1R5H A;  5E5B A;  3S6B A;  3CB5 A;  3MX6 A;  4U69 A;  5CDL A;  2NQ7 A;  4QR8 A;  1XNZ A;  3Q6D A;  4U6W A;  3PKD A;  2GG7 A;  4IDY A;  1QXW A;  3PKB A;  5D6E A;  4U73 A;  1XGS A;  4IF7 A;  1MAT A;  4ZNG A;  4U71 A;  4IU6 A;  5CDE A;  5FCF A;  2B3K A;  4IEC A;  2G6P A;  2GG2 A;  4ZWP A;  2EA2 A;  3BIP A;  1N51 A;  1WKM A;  1KP0 A;  3CTZ A;  1WLR A;  2IW2 A;  1KQ0 A;  3FMR A;  4PV4 A;  4RZZ A;  2ADU A;  5D6F A;  1C21 A;  1W7V A;  4IKS A;  4S00 A;  1O0X A;  2V3Z A;  4FKC A;  1B59 A;  2GU5 A;  4IKU A;  5CIK A;  4U6Z A;  2BHC A;  3IG4 A;  1R5G A;  2P98 A;  3TAV A;  1C23 A;  5CDV A;  1WL9 A;  4FLL A;  4PNC A;  2GU6 A;  2Q8K A;  2B3H A;  4ZWU A;  2BWV A;  3BIQ A;  4U75 A;  5CLS A;  2GG5 A;  3FM3 A;  2GGB A;  4A6W A;  1YVM A;  2BH3 A;  2OAZ A;  4RGZ 1;  4U1B A;  4JUQ A;  2GA2 A;  3CB6 A;  2P9A A;  1XGM A;  5CE6 A;  1QZY A;  2Q94 A;  2V3X A;  4IKR A;  1B6A A;  2EA4 A;  2V6C A;  5CNX A;  4RZY A;  2GU4 A;  3L7G A;  2GU7 A;  2Q95 A;  3IU8 A;  4KM3 A;  2EVC A;  4U6J A;  2GZ5 A;  2BHB A;  4IPA A;  2P99 A;  2BWX A;  3IU7 A;  4S2R P;  1R58 A;  4HXX A;  2B3L A;  1W2M A;  4MAT A;  1C22 A;  2GG3 A;  2GGC A;  4FO7 A;  4U70 A;  3BIT A;  2GG9 A;  2NQ6 A;  4B28 A;  2MAT A;  1A16 A;  1WL6 A;  4S2T P;  4FLI A;  1XGN A;  2BWY A;  3L24 A;  1YW7 A;  1WBQ A;  2BHA A;  2GG0 A;  2Q96 A;  4FLJ A;  1PV9 A;  2GTX A;  3MAT A;  4Z7M A;  4IKT A;  5JFR A;  1KQ9 A;  4U6E A;  1YW9 A;  3ROR A; 
#chains in the Genus database with same CATH topology
 1CHM A;  1YJ3 A;  1QXY A;  4U6C A;  2EVM A;  1WY2 A;  2BHD A;  2BWW A;  2Q93 A;  2BWT A;  4FO8 A;  3PKC A;  4OOK A;  5JI6 A;  4R60 A;  1QXZ A;  2GG8 A;  3IU9 A;  2ZSG A;  2V3Y A;  1BN5 A;  1Y1N A;  1XGO A;  2BWU A;  4ZWO A;  1BOA A;  2OKN A;  4FUK A;  2EVO A;  2HOW A;  4A6V A;  4U76 A;  1C27 A;  1M35 A;  3FMQ A;  4FLK A;  5JHU A;  1C24 A;  3PKA A;  3RVA A;  2BB7 A;  5FCH A;  4EGE A;  2BWS A;  2BN7 A;  3D27 A;  3MR1 A;  1YW8 A;  2DFI A;  3PKE A;  3TB5 A;  2Q92 A;  4S01 A;  1WN1 A;  1JAW A;  1R5H A;  5E5B A;  3S6B A;  3CB5 A;  3MX6 A;  4U69 A;  5CDL A;  2NQ7 A;  4QR8 A;  1XNZ A;  3Q6D A;  4U6W A;  3PKD A;  2GG7 A;  4IDY A;  1QXW A;  3PKB A;  5D6E A;  4U73 A;  1XGS A;  4IF7 A;  1MAT A;  4ZNG A;  4U71 A;  4IU6 A;  5CDE A;  5FCF A;  2B3K A;  4IEC A;  2G6P A;  2GG2 A;  4ZWP A;  2EA2 A;  3BIP A;  1N51 A;  1WKM A;  1KP0 A;  3CTZ A;  1WLR A;  2IW2 A;  1KQ0 A;  3FMR A;  4PV4 A;  4RZZ A;  2ADU A;  5D6F A;  1C21 A;  1W7V A;  4IKS A;  4S00 A;  1O0X A;  2V3Z A;  4FKC A;  1B59 A;  2GU5 A;  4IKU A;  5CIK A;  4U6Z A;  2BHC A;  3IG4 A;  1R5G A;  2P98 A;  3TAV A;  1C23 A;  5CDV A;  1WL9 A;  4FLL A;  4PNC A;  2GU6 A;  2Q8K A;  2B3H A;  4ZWU A;  2BWV A;  3BIQ A;  4U75 A;  5CLS A;  2GG5 A;  3FM3 A;  2GGB A;  4A6W A;  1YVM A;  2BH3 A;  2OAZ A;  4RGZ 1;  4U1B A;  4JUQ A;  2GA2 A;  3CB6 A;  2P9A A;  1XGM A;  5CE6 A;  1QZY A;  2Q94 A;  2V3X A;  4IKR A;  1B6A A;  2EA4 A;  2V6C A;  5CNX A;  4RZY A;  2GU4 A;  3L7G A;  2GU7 A;  2Q95 A;  3IU8 A;  4KM3 A;  2EVC A;  4U6J A;  2GZ5 A;  2BHB A;  4IPA A;  2P99 A;  2BWX A;  3IU7 A;  4S2R P;  1R58 A;  4HXX A;  2B3L A;  1W2M A;  4MAT A;  1C22 A;  2GG3 A;  2GGC A;  4FO7 A;  4U70 A;  3BIT A;  2GG9 A;  2NQ6 A;  4B28 A;  2MAT A;  1A16 A;  1WL6 A;  4S2T P;  4FLI A;  1XGN A;  2BWY A;  3L24 A;  1YW7 A;  1WBQ A;  2BHA A;  2GG0 A;  2Q96 A;  4FLJ A;  1PV9 A;  2GTX A;  3MAT A;  4Z7M A;  4IKT A;  5JFR A;  1KQ9 A;  4U6E A;  1YW9 A;  3ROR A; 
#chains in the Genus database with same CATH homology
 1CHM A;  1YJ3 A;  1QXY A;  4U6C A;  2EVM A;  1WY2 A;  2BHD A;  2BWW A;  2Q93 A;  2BWT A;  4FO8 A;  3PKC A;  4OOK A;  5JI6 A;  4R60 A;  1QXZ A;  2GG8 A;  3IU9 A;  2ZSG A;  2V3Y A;  1BN5 A;  1Y1N A;  1XGO A;  2BWU A;  4ZWO A;  1BOA A;  2OKN A;  4FUK A;  2EVO A;  2HOW A;  4A6V A;  4U76 A;  1C27 A;  1M35 A;  3FMQ A;  4FLK A;  5JHU A;  1C24 A;  3PKA A;  3RVA A;  2BB7 A;  5FCH A;  4EGE A;  2BWS A;  2BN7 A;  3D27 A;  3MR1 A;  1YW8 A;  2DFI A;  3PKE A;  3TB5 A;  2Q92 A;  4S01 A;  1WN1 A;  1JAW A;  1R5H A;  5E5B A;  3S6B A;  3CB5 A;  3MX6 A;  4U69 A;  5CDL A;  2NQ7 A;  4QR8 A;  1XNZ A;  3Q6D A;  4U6W A;  3PKD A;  2GG7 A;  4IDY A;  1QXW A;  3PKB A;  5D6E A;  4U73 A;  1XGS A;  4IF7 A;  1MAT A;  4ZNG A;  4U71 A;  4IU6 A;  5CDE A;  5FCF A;  2B3K A;  4IEC A;  2G6P A;  2GG2 A;  4ZWP A;  2EA2 A;  3BIP A;  1N51 A;  1WKM A;  1KP0 A;  3CTZ A;  1WLR A;  2IW2 A;  1KQ0 A;  3FMR A;  4PV4 A;  4RZZ A;  2ADU A;  5D6F A;  1C21 A;  1W7V A;  4IKS A;  4S00 A;  1O0X A;  2V3Z A;  4FKC A;  1B59 A;  2GU5 A;  4IKU A;  5CIK A;  4U6Z A;  2BHC A;  3IG4 A;  1R5G A;  2P98 A;  3TAV A;  1C23 A;  5CDV A;  1WL9 A;  4FLL A;  4PNC A;  2GU6 A;  2Q8K A;  2B3H A;  4ZWU A;  2BWV A;  3BIQ A;  4U75 A;  5CLS A;  2GG5 A;  3FM3 A;  2GGB A;  4A6W A;  1YVM A;  2BH3 A;  2OAZ A;  4RGZ 1;  4U1B A;  4JUQ A;  2GA2 A;  3CB6 A;  2P9A A;  1XGM A;  5CE6 A;  1QZY A;  2Q94 A;  2V3X A;  4IKR A;  1B6A A;  2EA4 A;  2V6C A;  5CNX A;  4RZY A;  2GU4 A;  3L7G A;  2GU7 A;  2Q95 A;  3IU8 A;  4KM3 A;  2EVC A;  4U6J A;  2GZ5 A;  2BHB A;  4IPA A;  2P99 A;  2BWX A;  3IU7 A;  4S2R P;  1R58 A;  4HXX A;  2B3L A;  1W2M A;  4MAT A;  1C22 A;  2GG3 A;  2GGC A;  4FO7 A;  4U70 A;  3BIT A;  2GG9 A;  2NQ6 A;  4B28 A;  2MAT A;  1A16 A;  1WL6 A;  4S2T P;  4FLI A;  1XGN A;  2BWY A;  3L24 A;  1YW7 A;  1WBQ A;  2BHA A;  2GG0 A;  2Q96 A;  4FLJ A;  1PV9 A;  2GTX A;  3MAT A;  4Z7M A;  4IKT A;  5JFR A;  1KQ9 A;  4U6E A;  1YW9 A;  3ROR A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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