2GGCA

Novel bacterial methionine aminopeptidase inhibitors
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
263
structure length
263
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Serendipitous discovery of novel bacterial methionine aminopeptidase inhibitors.
pubmed doi rcsb
source organism Escherichia coli k12
total genus 87
structure length 263
sequence length 263
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-03-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2ggcA00
2GGBA 1R58A 3FMRA 4U6EA 3CTZA 1WY2A 2GG8A 4PNCA 3BITA 1YJ3A 2DFIA 4ZWOA 4IDYA 1C27A 3TB5A 4S01A 1WBQA 3IU9A 4RZZA 2GU7A 1R5GA 4FLLA 1WL9A 2B3LA 1QZYA 2BHCA 4U6CA 4A6VA 1YW7A 2NQ7A 4FO7A 5JI6A 2BHDA 2B3HA 2NQ6A 2Q93A 2GG9A 1CHMA 2P99A 2P9AA 4EGEA 4IKSA 4IPAA 2ADUA 2V3XA 2GU6A 3Q6DA 2BWUA 2B3KA 1PV9A 5FCFA 2BH3A 1B59A 2GG2A 3S6BA 1KQ0A 2EVOA 1W7VA 5JFRA 2EVMA 2MATA 5CIKA 2ZSGA 3CB6A 3MATA 4A6WA 1YW8A 3RVAA 4ZNGA 2G6PA 2Q95A 1XGSA 1A16A 1XGOA 5E5BA 4RGZ1 3IG4A 3PKCA 4FLIA 2Q8KA 1C23A 1C21A 4ZWUA 2GGCA 3D27A 2BWVA 1XNZA 1WLRA 2EVCA 3BIQA 4QR8A 2HOWA 5CDVA 2EA4A 1C24A 5D6EA 4IKUA 1N51A 4R60A 1C22A 4FLJA 4OOKA 2GU4A 5JHUA 2GTXA 3FMQA 1W2MA 1YW9A 1KQ9A 3PKDA 4U6JA 2Q94A 2Q96A 4FKCA 1WN1A 1XGNA 1JAWA 2BN7A 2Q92A 3FM3A 3L24A 5CNXA 5CDLA 2BWTA 1KP0A 1M35A 3PKAA 2V3YA 4S2RP 2BB7A 2GG3A 1WKMA 4IKRA 4RZYA 1YVMA 1BN5A 1Y1NA 3IU8A 2GA2A 2BWYA 4U73A 2V3ZA 2V6CA 5CE6A 2EA2A 1MATA 3PKEA 5D6FA 2BHBA 5CDEA 2GZ5A 4ZWPA 1BOAA 4U75A 3PKBA 3TAVA 4S00A 4B28A 2P98A 4Z7MA 3MX6A 2GG5A 1QXYA 1R5HA 4U1BA 4FUKA 2BWXA 1B6AA 4U69A 3L7GA 2IW2A 4IECA 3CB5A 2GG0A 4HXXA 2OKNA 5CLSA 4KM3A 1XGMA 2GG7A 4JUQA 4U76A 4IU6A 4U6ZA 2BWWA 3MR1A 4FLKA 2OAZA 1WL6A 4S2TP 3RORA 1QXZA 4IF7A 4PV4A 4MATA 4U70A 4U71A 3IU7A 5FCHA 1QXWA 2BWSA 2GU5A 1O0XA 4FO8A 4IKTA 4U6WA 3BIPA 2BHAA
chains in the Genus database with same CATH superfamily
2GGBA 1R58A 3FMRA 4U6EA 3CTZA 1WY2A 2GG8A 4PNCA 3BITA 1YJ3A 2DFIA 4ZWOA 4IDYA 1C27A 3TB5A 4S01A 1WBQA 3IU9A 4RZZA 2GU7A 1R5GA 4FLLA 1WL9A 2B3LA 1QZYA 2BHCA 4U6CA 4A6VA 1YW7A 2NQ7A 4FO7A 5JI6A 2BHDA 2B3HA 2NQ6A 2Q93A 2GG9A 1CHMA 2P99A 2P9AA 4EGEA 4IKSA 4IPAA 2ADUA 2V3XA 2GU6A 3Q6DA 2BWUA 2B3KA 1PV9A 5FCFA 2BH3A 1B59A 2GG2A 3S6BA 1KQ0A 2EVOA 1W7VA 5JFRA 2EVMA 2MATA 5CIKA 2ZSGA 3CB6A 3MATA 4A6WA 1YW8A 3RVAA 4ZNGA 2G6PA 2Q95A 1XGSA 1A16A 1XGOA 5E5BA 4RGZ1 3IG4A 3PKCA 4FLIA 2Q8KA 1C23A 1C21A 4ZWUA 2GGCA 3D27A 2BWVA 1XNZA 1WLRA 2EVCA 3BIQA 4QR8A 2HOWA 5CDVA 2EA4A 1C24A 5D6EA 4IKUA 1N51A 4R60A 1C22A 4FLJA 4OOKA 2GU4A 5JHUA 2GTXA 3FMQA 1W2MA 1YW9A 1KQ9A 3PKDA 4U6JA 2Q94A 2Q96A 4FKCA 1WN1A 1XGNA 1JAWA 2BN7A 2Q92A 3FM3A 3L24A 5CNXA 5CDLA 2BWTA 1KP0A 1M35A 3PKAA 2V3YA 4S2RP 2BB7A 2GG3A 1WKMA 4IKRA 4RZYA 1YVMA 1BN5A 1Y1NA 3IU8A 2GA2A 2BWYA 4U73A 2V3ZA 2V6CA 5CE6A 2EA2A 1MATA 3PKEA 5D6FA 2BHBA 5CDEA 2GZ5A 4ZWPA 1BOAA 4U75A 3PKBA 3TAVA 4S00A 4B28A 2P98A 4Z7MA 3MX6A 2GG5A 1QXYA 1R5HA 4U1BA 4FUKA 2BWXA 1B6AA 4U69A 3L7GA 2IW2A 4IECA 3CB5A 2GG0A 4HXXA 2OKNA 5CLSA 4KM3A 1XGMA 2GG7A 4JUQA 4U76A 4IU6A 4U6ZA 2BWWA 3MR1A 4FLKA 2OAZA 1WL6A 4S2TP 3RORA 1QXZA 4IF7A 4PV4A 4MATA 4U70A 4U71A 3IU7A 5FCHA 1QXWA 2BWSA 2GU5A 1O0XA 4FO8A 4IKTA 4U6WA 3BIPA 2BHAA
chains in the Genus database with same CATH topology
2GGBA 1R58A 3FMRA 4U6EA 3CTZA 1WY2A 2GG8A 4PNCA 3BITA 1YJ3A 2DFIA 4ZWOA 4IDYA 1C27A 3TB5A 4S01A 1WBQA 3IU9A 4RZZA 2GU7A 1R5GA 4FLLA 1WL9A 2B3LA 1QZYA 2BHCA 4U6CA 4A6VA 1YW7A 2NQ7A 4FO7A 5JI6A 2BHDA 2B3HA 2NQ6A 2Q93A 2GG9A 1CHMA 2P99A 2P9AA 4EGEA 4IKSA 4IPAA 2ADUA 2V3XA 2GU6A 3Q6DA 2BWUA 2B3KA 1PV9A 5FCFA 2BH3A 1B59A 2GG2A 3S6BA 1KQ0A 2EVOA 1W7VA 5JFRA 2EVMA 2MATA 5CIKA 2ZSGA 3CB6A 3MATA 4A6WA 1YW8A 3RVAA 4ZNGA 2G6PA 2Q95A 1XGSA 1A16A 1XGOA 5E5BA 4RGZ1 3IG4A 3PKCA 4FLIA 2Q8KA 1C23A 1C21A 4ZWUA 2GGCA 3D27A 2BWVA 1XNZA 1WLRA 2EVCA 3BIQA 4QR8A 2HOWA 5CDVA 2EA4A 1C24A 5D6EA 4IKUA 1N51A 4R60A 1C22A 4FLJA 4OOKA 2GU4A 5JHUA 2GTXA 3FMQA 1W2MA 1YW9A 1KQ9A 3PKDA 4U6JA 2Q94A 2Q96A 4FKCA 1WN1A 1XGNA 1JAWA 2BN7A 2Q92A 3FM3A 3L24A 5CNXA 5CDLA 2BWTA 1KP0A 1M35A 3PKAA 2V3YA 4S2RP 2BB7A 2GG3A 1WKMA 4IKRA 4RZYA 1YVMA 1BN5A 1Y1NA 3IU8A 2GA2A 2BWYA 4U73A 2V3ZA 2V6CA 5CE6A 2EA2A 1MATA 3PKEA 5D6FA 2BHBA 5CDEA 2GZ5A 4ZWPA 1BOAA 4U75A 3PKBA 3TAVA 4S00A 4B28A 2P98A 4Z7MA 3MX6A 2GG5A 1QXYA 1R5HA 4U1BA 4FUKA 2BWXA 1B6AA 4U69A 3L7GA 2IW2A 4IECA 3CB5A 2GG0A 4HXXA 2OKNA 5CLSA 4KM3A 1XGMA 2GG7A 4JUQA 4U76A 4IU6A 4U6ZA 2BWWA 3MR1A 4FLKA 2OAZA 1WL6A 4S2TP 3RORA 1QXZA 4IF7A 4PV4A 4MATA 4U70A 4U71A 3IU7A 5FCHA 1QXWA 2BWSA 2GU5A 1O0XA 4FO8A 4IKTA 4U6WA 3BIPA 2BHAA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GGB A;  1R58 A;  3FMR A;  4U6E A;  3CTZ A;  1WY2 A;  2GG8 A;  4PNC A;  3BIT A;  1YJ3 A;  2DFI A;  4ZWO A;  4IDY A;  1C27 A;  3TB5 A;  4S01 A;  1WBQ A;  3IU9 A;  4RZZ A;  2GU7 A;  1R5G A;  4FLL A;  1WL9 A;  2B3L A;  1QZY A;  2BHC A;  4U6C A;  4A6V A;  1YW7 A;  2NQ7 A;  4FO7 A;  5JI6 A;  2BHD A;  2B3H A;  2NQ6 A;  2Q93 A;  2GG9 A;  1CHM A;  2P99 A;  2P9A A;  4EGE A;  4IKS A;  4IPA A;  2ADU A;  2V3X A;  2GU6 A;  3Q6D A;  2BWU A;  2B3K A;  1PV9 A;  5FCF A;  2BH3 A;  1B59 A;  2GG2 A;  3S6B A;  1KQ0 A;  2EVO A;  1W7V A;  5JFR A;  2EVM A;  2MAT A;  5CIK A;  2ZSG A;  3CB6 A;  3MAT A;  4A6W A;  1YW8 A;  3RVA A;  4ZNG A;  2G6P A;  2Q95 A;  1XGS A;  1A16 A;  1XGO A;  5E5B A;  4RGZ 1;  3IG4 A;  3PKC A;  4FLI A;  2Q8K A;  1C23 A;  1C21 A;  4ZWU A;  2GGC A;  3D27 A;  2BWV A;  1XNZ A;  1WLR A;  2EVC A;  3BIQ A;  4QR8 A;  2HOW A;  5CDV A;  2EA4 A;  1C24 A;  5D6E A;  4IKU A;  1N51 A;  4R60 A;  1C22 A;  4FLJ A;  4OOK A;  2GU4 A;  5JHU A;  2GTX A;  3FMQ A;  1W2M A;  1YW9 A;  1KQ9 A;  3PKD A;  4U6J A;  2Q94 A;  2Q96 A;  4FKC A;  1WN1 A;  1XGN A;  1JAW A;  2BN7 A;  2Q92 A;  3FM3 A;  3L24 A;  5CNX A;  5CDL A;  2BWT A;  1KP0 A;  1M35 A;  3PKA A;  2V3Y A;  4S2R P;  2BB7 A;  2GG3 A;  1WKM A;  4IKR A;  4RZY A;  1YVM A;  1BN5 A;  1Y1N A;  3IU8 A;  2GA2 A;  2BWY A;  4U73 A;  2V3Z A;  2V6C A;  5CE6 A;  2EA2 A;  1MAT A;  3PKE A;  5D6F A;  2BHB A;  5CDE A;  2GZ5 A;  4ZWP A;  1BOA A;  4U75 A;  3PKB A;  3TAV A;  4S00 A;  4B28 A;  2P98 A;  4Z7M A;  3MX6 A;  2GG5 A;  1QXY A;  1R5H A;  4U1B A;  4FUK A;  2BWX A;  1B6A A;  4U69 A;  3L7G A;  2IW2 A;  4IEC A;  3CB5 A;  2GG0 A;  4HXX A;  2OKN A;  5CLS A;  4KM3 A;  1XGM A;  2GG7 A;  4JUQ A;  4U76 A;  4IU6 A;  4U6Z A;  2BWW A;  3MR1 A;  4FLK A;  2OAZ A;  1WL6 A;  4S2T P;  3ROR A;  1QXZ A;  4IF7 A;  4PV4 A;  4MAT A;  4U70 A;  4U71 A;  3IU7 A;  5FCH A;  1QXW A;  2BWS A;  2GU5 A;  1O0X A;  4FO8 A;  4IKT A;  4U6W A;  3BIP A;  2BHA A; 
#chains in the Genus database with same CATH topology
 2GGB A;  1R58 A;  3FMR A;  4U6E A;  3CTZ A;  1WY2 A;  2GG8 A;  4PNC A;  3BIT A;  1YJ3 A;  2DFI A;  4ZWO A;  4IDY A;  1C27 A;  3TB5 A;  4S01 A;  1WBQ A;  3IU9 A;  4RZZ A;  2GU7 A;  1R5G A;  4FLL A;  1WL9 A;  2B3L A;  1QZY A;  2BHC A;  4U6C A;  4A6V A;  1YW7 A;  2NQ7 A;  4FO7 A;  5JI6 A;  2BHD A;  2B3H A;  2NQ6 A;  2Q93 A;  2GG9 A;  1CHM A;  2P99 A;  2P9A A;  4EGE A;  4IKS A;  4IPA A;  2ADU A;  2V3X A;  2GU6 A;  3Q6D A;  2BWU A;  2B3K A;  1PV9 A;  5FCF A;  2BH3 A;  1B59 A;  2GG2 A;  3S6B A;  1KQ0 A;  2EVO A;  1W7V A;  5JFR A;  2EVM A;  2MAT A;  5CIK A;  2ZSG A;  3CB6 A;  3MAT A;  4A6W A;  1YW8 A;  3RVA A;  4ZNG A;  2G6P A;  2Q95 A;  1XGS A;  1A16 A;  1XGO A;  5E5B A;  4RGZ 1;  3IG4 A;  3PKC A;  4FLI A;  2Q8K A;  1C23 A;  1C21 A;  4ZWU A;  2GGC A;  3D27 A;  2BWV A;  1XNZ A;  1WLR A;  2EVC A;  3BIQ A;  4QR8 A;  2HOW A;  5CDV A;  2EA4 A;  1C24 A;  5D6E A;  4IKU A;  1N51 A;  4R60 A;  1C22 A;  4FLJ A;  4OOK A;  2GU4 A;  5JHU A;  2GTX A;  3FMQ A;  1W2M A;  1YW9 A;  1KQ9 A;  3PKD A;  4U6J A;  2Q94 A;  2Q96 A;  4FKC A;  1WN1 A;  1XGN A;  1JAW A;  2BN7 A;  2Q92 A;  3FM3 A;  3L24 A;  5CNX A;  5CDL A;  2BWT A;  1KP0 A;  1M35 A;  3PKA A;  2V3Y A;  4S2R P;  2BB7 A;  2GG3 A;  1WKM A;  4IKR A;  4RZY A;  1YVM A;  1BN5 A;  1Y1N A;  3IU8 A;  2GA2 A;  2BWY A;  4U73 A;  2V3Z A;  2V6C A;  5CE6 A;  2EA2 A;  1MAT A;  3PKE A;  5D6F A;  2BHB A;  5CDE A;  2GZ5 A;  4ZWP A;  1BOA A;  4U75 A;  3PKB A;  3TAV A;  4S00 A;  4B28 A;  2P98 A;  4Z7M A;  3MX6 A;  2GG5 A;  1QXY A;  1R5H A;  4U1B A;  4FUK A;  2BWX A;  1B6A A;  4U69 A;  3L7G A;  2IW2 A;  4IEC A;  3CB5 A;  2GG0 A;  4HXX A;  2OKN A;  5CLS A;  4KM3 A;  1XGM A;  2GG7 A;  4JUQ A;  4U76 A;  4IU6 A;  4U6Z A;  2BWW A;  3MR1 A;  4FLK A;  2OAZ A;  1WL6 A;  4S2T P;  3ROR A;  1QXZ A;  4IF7 A;  4PV4 A;  4MAT A;  4U70 A;  4U71 A;  3IU7 A;  5FCH A;  1QXW A;  2BWS A;  2GU5 A;  1O0X A;  4FO8 A;  4IKT A;  4U6W A;  3BIP A;  2BHA A; 
#chains in the Genus database with same CATH homology
 2GGB A;  1R58 A;  3FMR A;  4U6E A;  3CTZ A;  1WY2 A;  2GG8 A;  4PNC A;  3BIT A;  1YJ3 A;  2DFI A;  4ZWO A;  4IDY A;  1C27 A;  3TB5 A;  4S01 A;  1WBQ A;  3IU9 A;  4RZZ A;  2GU7 A;  1R5G A;  4FLL A;  1WL9 A;  2B3L A;  1QZY A;  2BHC A;  4U6C A;  4A6V A;  1YW7 A;  2NQ7 A;  4FO7 A;  5JI6 A;  2BHD A;  2B3H A;  2NQ6 A;  2Q93 A;  2GG9 A;  1CHM A;  2P99 A;  2P9A A;  4EGE A;  4IKS A;  4IPA A;  2ADU A;  2V3X A;  2GU6 A;  3Q6D A;  2BWU A;  2B3K A;  1PV9 A;  5FCF A;  2BH3 A;  1B59 A;  2GG2 A;  3S6B A;  1KQ0 A;  2EVO A;  1W7V A;  5JFR A;  2EVM A;  2MAT A;  5CIK A;  2ZSG A;  3CB6 A;  3MAT A;  4A6W A;  1YW8 A;  3RVA A;  4ZNG A;  2G6P A;  2Q95 A;  1XGS A;  1A16 A;  1XGO A;  5E5B A;  4RGZ 1;  3IG4 A;  3PKC A;  4FLI A;  2Q8K A;  1C23 A;  1C21 A;  4ZWU A;  2GGC A;  3D27 A;  2BWV A;  1XNZ A;  1WLR A;  2EVC A;  3BIQ A;  4QR8 A;  2HOW A;  5CDV A;  2EA4 A;  1C24 A;  5D6E A;  4IKU A;  1N51 A;  4R60 A;  1C22 A;  4FLJ A;  4OOK A;  2GU4 A;  5JHU A;  2GTX A;  3FMQ A;  1W2M A;  1YW9 A;  1KQ9 A;  3PKD A;  4U6J A;  2Q94 A;  2Q96 A;  4FKC A;  1WN1 A;  1XGN A;  1JAW A;  2BN7 A;  2Q92 A;  3FM3 A;  3L24 A;  5CNX A;  5CDL A;  2BWT A;  1KP0 A;  1M35 A;  3PKA A;  2V3Y A;  4S2R P;  2BB7 A;  2GG3 A;  1WKM A;  4IKR A;  4RZY A;  1YVM A;  1BN5 A;  1Y1N A;  3IU8 A;  2GA2 A;  2BWY A;  4U73 A;  2V3Z A;  2V6C A;  5CE6 A;  2EA2 A;  1MAT A;  3PKE A;  5D6F A;  2BHB A;  5CDE A;  2GZ5 A;  4ZWP A;  1BOA A;  4U75 A;  3PKB A;  3TAV A;  4S00 A;  4B28 A;  2P98 A;  4Z7M A;  3MX6 A;  2GG5 A;  1QXY A;  1R5H A;  4U1B A;  4FUK A;  2BWX A;  1B6A A;  4U69 A;  3L7G A;  2IW2 A;  4IEC A;  3CB5 A;  2GG0 A;  4HXX A;  2OKN A;  5CLS A;  4KM3 A;  1XGM A;  2GG7 A;  4JUQ A;  4U76 A;  4IU6 A;  4U6Z A;  2BWW A;  3MR1 A;  4FLK A;  2OAZ A;  1WL6 A;  4S2T P;  3ROR A;  1QXZ A;  4IF7 A;  4PV4 A;  4MAT A;  4U70 A;  4U71 A;  3IU7 A;  5FCH A;  1QXW A;  2BWS A;  2GU5 A;  1O0X A;  4FO8 A;  4IKT A;  4U6W A;  3BIP A;  2BHA A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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