2GU4A

E. coli methionine aminopeptidase in complex with nlep, 1: 0.5, di-metalated
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
261
structure length
261
Chain Sequence
SIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural basis of catalysis by monometalated methionine aminopeptidase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords Methionine aminopeptidase
total genus 91
structure length 261
sequence length 261
chains with identical sequence B
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-04-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gu4A00
1XGOA 1A16A 2EVMA 4ZWUA 1R58A 3PKEA 4S01A 2ZSGA 1QXYA 1R5HA 2DFIA 2GZ5A 2HOWA 4FUKA 3IG4A 3BITA 3MX6A 3MATA 5FCFA 5JFRA 3IU9A 3RORA 2BN7A 2P99A 4RZZA 1N51A 2EA2A 3FMQA 1CHMA 2EVOA 3PKAA 2GU4A 1WKMA 1MATA 2BH3A 2B3KA 2GG5A 4U6ZA 3L7GA 2GGBA 4EGEA 1R5GA 2Q96A 4S2TP 4U71A 4IF7A 4IKSA 1XGNA 1KP0A 3Q6DA 2V3XA 3BIQA 1WN1A 2BHDA 4FO8A 4IKRA 3PKCA 1WL9A 1KQ0A 5CIKA 4RGZ1 4B28A 1B6AA 5JHUA 2BB7A 2GU6A 2NQ6A 2BHAA 2P98A 1C23A 2Q93A 4R60A 4U6JA 4QR8A 1YJ3A 1Y1NA 3CTZA 4S00A 2BHCA 2BWVA 2EA4A 4KM3A 2BWWA 2Q94A 4U76A 1WLRA 2Q95A 1WY2A 3IU8A 3BIPA 3L24A 4FO7A 4A6WA 1YVMA 2V3ZA 4IKUA 2GU7A 4FLKA 4FLIA 5FCHA 4JUQA 4IECA 2GG9A 3IU7A 4IDYA 4S2RP 2GG7A 1XGSA 2ADUA 3CB6A 2G6PA 2BWYA 1XGMA 1YW9A 2V3YA 2BWSA 5CLSA 2GG3A 2Q92A 1B59A 5D6FA 3CB5A 3PKBA 2MATA 1M35A 2NQ7A 3FMRA 1QXWA 4FKCA 4HXXA 3TB5A 1WL6A 2B3LA 4IPAA 4OOKA 4U6EA 1C21A 4U6CA 4ZWPA 4ZWOA 2P9AA 2BHBA 4PV4A 2Q8KA 4ZNGA 2GGCA 2GA2A 1BOAA 4U6WA 1C22A 4U69A 5CDEA 1YW7A 1W7VA 2BWXA 2GU5A 4U70A 2GG0A 3PKDA 4A6VA 4U73A 3RVAA 4PNCA 2B3HA 5CDVA 2BWUA 2GG2A 1QXZA 3FM3A 2OAZA 3MR1A 4RZYA 2GTXA 5CNXA 1JAWA 2V6CA 2GG8A 1WBQA 4FLJA 4Z7MA 1KQ9A 1C27A 3D27A 5CE6A 1PV9A 1W2MA 1QZYA 5CDLA 1YW8A 3S6BA 1C24A 2IW2A 5D6EA 1XNZA 5JI6A 2EVCA 1BN5A 2BWTA 4IU6A 4IKTA 4U75A 5E5BA 1O0XA 4MATA 4U1BA 2OKNA 4FLLA 3TAVA
chains in the Genus database with same CATH superfamily
1XGOA 1A16A 2EVMA 4ZWUA 1R58A 3PKEA 4S01A 2ZSGA 1QXYA 1R5HA 2DFIA 2GZ5A 2HOWA 4FUKA 3IG4A 3BITA 3MX6A 3MATA 5FCFA 5JFRA 3IU9A 3RORA 2BN7A 2P99A 4RZZA 1N51A 2EA2A 3FMQA 1CHMA 2EVOA 3PKAA 2GU4A 1WKMA 1MATA 2BH3A 2B3KA 2GG5A 4U6ZA 3L7GA 2GGBA 4EGEA 1R5GA 2Q96A 4S2TP 4U71A 4IF7A 4IKSA 1XGNA 1KP0A 3Q6DA 2V3XA 3BIQA 1WN1A 2BHDA 4FO8A 4IKRA 3PKCA 1WL9A 1KQ0A 5CIKA 4RGZ1 4B28A 1B6AA 5JHUA 2BB7A 2GU6A 2NQ6A 2BHAA 2P98A 1C23A 2Q93A 4R60A 4U6JA 4QR8A 1YJ3A 1Y1NA 3CTZA 4S00A 2BHCA 2BWVA 2EA4A 4KM3A 2BWWA 2Q94A 4U76A 1WLRA 2Q95A 1WY2A 3IU8A 3BIPA 3L24A 4FO7A 4A6WA 1YVMA 2V3ZA 4IKUA 2GU7A 4FLKA 4FLIA 5FCHA 4JUQA 4IECA 2GG9A 3IU7A 4IDYA 4S2RP 2GG7A 1XGSA 2ADUA 3CB6A 2G6PA 2BWYA 1XGMA 1YW9A 2V3YA 2BWSA 5CLSA 2GG3A 2Q92A 1B59A 5D6FA 3CB5A 3PKBA 2MATA 1M35A 2NQ7A 3FMRA 1QXWA 4FKCA 4HXXA 3TB5A 1WL6A 2B3LA 4IPAA 4OOKA 4U6EA 1C21A 4U6CA 4ZWPA 4ZWOA 2P9AA 2BHBA 4PV4A 2Q8KA 4ZNGA 2GGCA 2GA2A 1BOAA 4U6WA 1C22A 4U69A 5CDEA 1YW7A 1W7VA 2BWXA 2GU5A 4U70A 2GG0A 3PKDA 4A6VA 4U73A 3RVAA 4PNCA 2B3HA 5CDVA 2BWUA 2GG2A 1QXZA 3FM3A 2OAZA 3MR1A 4RZYA 2GTXA 5CNXA 1JAWA 2V6CA 2GG8A 1WBQA 4FLJA 4Z7MA 1KQ9A 1C27A 3D27A 5CE6A 1PV9A 1W2MA 1QZYA 5CDLA 1YW8A 3S6BA 1C24A 2IW2A 5D6EA 1XNZA 5JI6A 2EVCA 1BN5A 2BWTA 4IU6A 4IKTA 4U75A 5E5BA 1O0XA 4MATA 4U1BA 2OKNA 4FLLA 3TAVA
chains in the Genus database with same CATH topology
1XGOA 1A16A 2EVMA 4ZWUA 1R58A 3PKEA 4S01A 2ZSGA 1QXYA 1R5HA 2DFIA 2GZ5A 2HOWA 4FUKA 3IG4A 3BITA 3MX6A 3MATA 5FCFA 5JFRA 3IU9A 3RORA 2BN7A 2P99A 4RZZA 1N51A 2EA2A 3FMQA 1CHMA 2EVOA 3PKAA 2GU4A 1WKMA 1MATA 2BH3A 2B3KA 2GG5A 4U6ZA 3L7GA 2GGBA 4EGEA 1R5GA 2Q96A 4S2TP 4U71A 4IF7A 4IKSA 1XGNA 1KP0A 3Q6DA 2V3XA 3BIQA 1WN1A 2BHDA 4FO8A 4IKRA 3PKCA 1WL9A 1KQ0A 5CIKA 4RGZ1 4B28A 1B6AA 5JHUA 2BB7A 2GU6A 2NQ6A 2BHAA 2P98A 1C23A 2Q93A 4R60A 4U6JA 4QR8A 1YJ3A 1Y1NA 3CTZA 4S00A 2BHCA 2BWVA 2EA4A 4KM3A 2BWWA 2Q94A 4U76A 1WLRA 2Q95A 1WY2A 3IU8A 3BIPA 3L24A 4FO7A 4A6WA 1YVMA 2V3ZA 4IKUA 2GU7A 4FLKA 4FLIA 5FCHA 4JUQA 4IECA 2GG9A 3IU7A 4IDYA 4S2RP 2GG7A 1XGSA 2ADUA 3CB6A 2G6PA 2BWYA 1XGMA 1YW9A 2V3YA 2BWSA 5CLSA 2GG3A 2Q92A 1B59A 5D6FA 3CB5A 3PKBA 2MATA 1M35A 2NQ7A 3FMRA 1QXWA 4FKCA 4HXXA 3TB5A 1WL6A 2B3LA 4IPAA 4OOKA 4U6EA 1C21A 4U6CA 4ZWPA 4ZWOA 2P9AA 2BHBA 4PV4A 2Q8KA 4ZNGA 2GGCA 2GA2A 1BOAA 4U6WA 1C22A 4U69A 5CDEA 1YW7A 1W7VA 2BWXA 2GU5A 4U70A 2GG0A 3PKDA 4A6VA 4U73A 3RVAA 4PNCA 2B3HA 5CDVA 2BWUA 2GG2A 1QXZA 3FM3A 2OAZA 3MR1A 4RZYA 2GTXA 5CNXA 1JAWA 2V6CA 2GG8A 1WBQA 4FLJA 4Z7MA 1KQ9A 1C27A 3D27A 5CE6A 1PV9A 1W2MA 1QZYA 5CDLA 1YW8A 3S6BA 1C24A 2IW2A 5D6EA 1XNZA 5JI6A 2EVCA 1BN5A 2BWTA 4IU6A 4IKTA 4U75A 5E5BA 1O0XA 4MATA 4U1BA 2OKNA 4FLLA 3TAVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1XGO A;  1A16 A;  2EVM A;  4ZWU A;  1R58 A;  3PKE A;  4S01 A;  2ZSG A;  1QXY A;  1R5H A;  2DFI A;  2GZ5 A;  2HOW A;  4FUK A;  3IG4 A;  3BIT A;  3MX6 A;  3MAT A;  5FCF A;  5JFR A;  3IU9 A;  3ROR A;  2BN7 A;  2P99 A;  4RZZ A;  1N51 A;  2EA2 A;  3FMQ A;  1CHM A;  2EVO A;  3PKA A;  2GU4 A;  1WKM A;  1MAT A;  2BH3 A;  2B3K A;  2GG5 A;  4U6Z A;  3L7G A;  2GGB A;  4EGE A;  1R5G A;  2Q96 A;  4S2T P;  4U71 A;  4IF7 A;  4IKS A;  1XGN A;  1KP0 A;  3Q6D A;  2V3X A;  3BIQ A;  1WN1 A;  2BHD A;  4FO8 A;  4IKR A;  3PKC A;  1WL9 A;  1KQ0 A;  5CIK A;  4RGZ 1;  4B28 A;  1B6A A;  5JHU A;  2BB7 A;  2GU6 A;  2NQ6 A;  2BHA A;  2P98 A;  1C23 A;  2Q93 A;  4R60 A;  4U6J A;  4QR8 A;  1YJ3 A;  1Y1N A;  3CTZ A;  4S00 A;  2BHC A;  2BWV A;  2EA4 A;  4KM3 A;  2BWW A;  2Q94 A;  4U76 A;  1WLR A;  2Q95 A;  1WY2 A;  3IU8 A;  3BIP A;  3L24 A;  4FO7 A;  4A6W A;  1YVM A;  2V3Z A;  4IKU A;  2GU7 A;  4FLK A;  4FLI A;  5FCH A;  4JUQ A;  4IEC A;  2GG9 A;  3IU7 A;  4IDY A;  4S2R P;  2GG7 A;  1XGS A;  2ADU A;  3CB6 A;  2G6P A;  2BWY A;  1XGM A;  1YW9 A;  2V3Y A;  2BWS A;  5CLS A;  2GG3 A;  2Q92 A;  1B59 A;  5D6F A;  3CB5 A;  3PKB A;  2MAT A;  1M35 A;  2NQ7 A;  3FMR A;  1QXW A;  4FKC A;  4HXX A;  3TB5 A;  1WL6 A;  2B3L A;  4IPA A;  4OOK A;  4U6E A;  1C21 A;  4U6C A;  4ZWP A;  4ZWO A;  2P9A A;  2BHB A;  4PV4 A;  2Q8K A;  4ZNG A;  2GGC A;  2GA2 A;  1BOA A;  4U6W A;  1C22 A;  4U69 A;  5CDE A;  1YW7 A;  1W7V A;  2BWX A;  2GU5 A;  4U70 A;  2GG0 A;  3PKD A;  4A6V A;  4U73 A;  3RVA A;  4PNC A;  2B3H A;  5CDV A;  2BWU A;  2GG2 A;  1QXZ A;  3FM3 A;  2OAZ A;  3MR1 A;  4RZY A;  2GTX A;  5CNX A;  1JAW A;  2V6C A;  2GG8 A;  1WBQ A;  4FLJ A;  4Z7M A;  1KQ9 A;  1C27 A;  3D27 A;  5CE6 A;  1PV9 A;  1W2M A;  1QZY A;  5CDL A;  1YW8 A;  3S6B A;  1C24 A;  2IW2 A;  5D6E A;  1XNZ A;  5JI6 A;  2EVC A;  1BN5 A;  2BWT A;  4IU6 A;  4IKT A;  4U75 A;  5E5B A;  1O0X A;  4MAT A;  4U1B A;  2OKN A;  4FLL A;  3TAV A; 
#chains in the Genus database with same CATH topology
 1XGO A;  1A16 A;  2EVM A;  4ZWU A;  1R58 A;  3PKE A;  4S01 A;  2ZSG A;  1QXY A;  1R5H A;  2DFI A;  2GZ5 A;  2HOW A;  4FUK A;  3IG4 A;  3BIT A;  3MX6 A;  3MAT A;  5FCF A;  5JFR A;  3IU9 A;  3ROR A;  2BN7 A;  2P99 A;  4RZZ A;  1N51 A;  2EA2 A;  3FMQ A;  1CHM A;  2EVO A;  3PKA A;  2GU4 A;  1WKM A;  1MAT A;  2BH3 A;  2B3K A;  2GG5 A;  4U6Z A;  3L7G A;  2GGB A;  4EGE A;  1R5G A;  2Q96 A;  4S2T P;  4U71 A;  4IF7 A;  4IKS A;  1XGN A;  1KP0 A;  3Q6D A;  2V3X A;  3BIQ A;  1WN1 A;  2BHD A;  4FO8 A;  4IKR A;  3PKC A;  1WL9 A;  1KQ0 A;  5CIK A;  4RGZ 1;  4B28 A;  1B6A A;  5JHU A;  2BB7 A;  2GU6 A;  2NQ6 A;  2BHA A;  2P98 A;  1C23 A;  2Q93 A;  4R60 A;  4U6J A;  4QR8 A;  1YJ3 A;  1Y1N A;  3CTZ A;  4S00 A;  2BHC A;  2BWV A;  2EA4 A;  4KM3 A;  2BWW A;  2Q94 A;  4U76 A;  1WLR A;  2Q95 A;  1WY2 A;  3IU8 A;  3BIP A;  3L24 A;  4FO7 A;  4A6W A;  1YVM A;  2V3Z A;  4IKU A;  2GU7 A;  4FLK A;  4FLI A;  5FCH A;  4JUQ A;  4IEC A;  2GG9 A;  3IU7 A;  4IDY A;  4S2R P;  2GG7 A;  1XGS A;  2ADU A;  3CB6 A;  2G6P A;  2BWY A;  1XGM A;  1YW9 A;  2V3Y A;  2BWS A;  5CLS A;  2GG3 A;  2Q92 A;  1B59 A;  5D6F A;  3CB5 A;  3PKB A;  2MAT A;  1M35 A;  2NQ7 A;  3FMR A;  1QXW A;  4FKC A;  4HXX A;  3TB5 A;  1WL6 A;  2B3L A;  4IPA A;  4OOK A;  4U6E A;  1C21 A;  4U6C A;  4ZWP A;  4ZWO A;  2P9A A;  2BHB A;  4PV4 A;  2Q8K A;  4ZNG A;  2GGC A;  2GA2 A;  1BOA A;  4U6W A;  1C22 A;  4U69 A;  5CDE A;  1YW7 A;  1W7V A;  2BWX A;  2GU5 A;  4U70 A;  2GG0 A;  3PKD A;  4A6V A;  4U73 A;  3RVA A;  4PNC A;  2B3H A;  5CDV A;  2BWU A;  2GG2 A;  1QXZ A;  3FM3 A;  2OAZ A;  3MR1 A;  4RZY A;  2GTX A;  5CNX A;  1JAW A;  2V6C A;  2GG8 A;  1WBQ A;  4FLJ A;  4Z7M A;  1KQ9 A;  1C27 A;  3D27 A;  5CE6 A;  1PV9 A;  1W2M A;  1QZY A;  5CDL A;  1YW8 A;  3S6B A;  1C24 A;  2IW2 A;  5D6E A;  1XNZ A;  5JI6 A;  2EVC A;  1BN5 A;  2BWT A;  4IU6 A;  4IKT A;  4U75 A;  5E5B A;  1O0X A;  4MAT A;  4U1B A;  2OKN A;  4FLL A;  3TAV A; 
#chains in the Genus database with same CATH homology
 1XGO A;  1A16 A;  2EVM A;  4ZWU A;  1R58 A;  3PKE A;  4S01 A;  2ZSG A;  1QXY A;  1R5H A;  2DFI A;  2GZ5 A;  2HOW A;  4FUK A;  3IG4 A;  3BIT A;  3MX6 A;  3MAT A;  5FCF A;  5JFR A;  3IU9 A;  3ROR A;  2BN7 A;  2P99 A;  4RZZ A;  1N51 A;  2EA2 A;  3FMQ A;  1CHM A;  2EVO A;  3PKA A;  2GU4 A;  1WKM A;  1MAT A;  2BH3 A;  2B3K A;  2GG5 A;  4U6Z A;  3L7G A;  2GGB A;  4EGE A;  1R5G A;  2Q96 A;  4S2T P;  4U71 A;  4IF7 A;  4IKS A;  1XGN A;  1KP0 A;  3Q6D A;  2V3X A;  3BIQ A;  1WN1 A;  2BHD A;  4FO8 A;  4IKR A;  3PKC A;  1WL9 A;  1KQ0 A;  5CIK A;  4RGZ 1;  4B28 A;  1B6A A;  5JHU A;  2BB7 A;  2GU6 A;  2NQ6 A;  2BHA A;  2P98 A;  1C23 A;  2Q93 A;  4R60 A;  4U6J A;  4QR8 A;  1YJ3 A;  1Y1N A;  3CTZ A;  4S00 A;  2BHC A;  2BWV A;  2EA4 A;  4KM3 A;  2BWW A;  2Q94 A;  4U76 A;  1WLR A;  2Q95 A;  1WY2 A;  3IU8 A;  3BIP A;  3L24 A;  4FO7 A;  4A6W A;  1YVM A;  2V3Z A;  4IKU A;  2GU7 A;  4FLK A;  4FLI A;  5FCH A;  4JUQ A;  4IEC A;  2GG9 A;  3IU7 A;  4IDY A;  4S2R P;  2GG7 A;  1XGS A;  2ADU A;  3CB6 A;  2G6P A;  2BWY A;  1XGM A;  1YW9 A;  2V3Y A;  2BWS A;  5CLS A;  2GG3 A;  2Q92 A;  1B59 A;  5D6F A;  3CB5 A;  3PKB A;  2MAT A;  1M35 A;  2NQ7 A;  3FMR A;  1QXW A;  4FKC A;  4HXX A;  3TB5 A;  1WL6 A;  2B3L A;  4IPA A;  4OOK A;  4U6E A;  1C21 A;  4U6C A;  4ZWP A;  4ZWO A;  2P9A A;  2BHB A;  4PV4 A;  2Q8K A;  4ZNG A;  2GGC A;  2GA2 A;  1BOA A;  4U6W A;  1C22 A;  4U69 A;  5CDE A;  1YW7 A;  1W7V A;  2BWX A;  2GU5 A;  4U70 A;  2GG0 A;  3PKD A;  4A6V A;  4U73 A;  3RVA A;  4PNC A;  2B3H A;  5CDV A;  2BWU A;  2GG2 A;  1QXZ A;  3FM3 A;  2OAZ A;  3MR1 A;  4RZY A;  2GTX A;  5CNX A;  1JAW A;  2V6C A;  2GG8 A;  1WBQ A;  4FLJ A;  4Z7M A;  1KQ9 A;  1C27 A;  3D27 A;  5CE6 A;  1PV9 A;  1W2M A;  1QZY A;  5CDL A;  1YW8 A;  3S6B A;  1C24 A;  2IW2 A;  5D6E A;  1XNZ A;  5JI6 A;  2EVC A;  1BN5 A;  2BWT A;  4IU6 A;  4IKT A;  4U75 A;  5E5B A;  1O0X A;  4MAT A;  4U1B A;  2OKN A;  4FLL A;  3TAV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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