2GZ5A

Human type 1 methionine aminopeptidase in complex with ovalicin at 1.1 ang
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the angiogenesis inhibitor ovalicin bound to its noncognate target, human Type 1 methionine aminopeptidase.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-05-10

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2gz5A00
3BIQA 2BWXA 2BN7A 3RORA 2DFIA 4S00A 4HXXA 2MATA 2V3YA 4RZYA 1CHMA 4ZNGA 4IKUA 1QXWA 1M35A 1MATA 1QZYA 4U70A 5FCHA 3CB6A 4A6WA 4IDYA 1C21A 4KM3A 1XGOA 3D27A 3PKAA 4U69A 4U6EA 1A16A 1YW7A 1WBQA 2ADUA 3IU9A 2GU4A 1W2MA 2GG2A 2BWWA 2NQ7A 5E5BA 1Y1NA 4FLKA 2V3XA 1C24A 1WL6A 3FMRA 4FO8A 5CDEA 5CDLA 5JI6A 3FMQA 5CE6A 2ZSGA 2P98A 4ZWPA 1WY2A 4IPAA 1QXZA 4U6JA 2BHAA 1YVMA 5CLSA 1WL9A 2BH3A 3TAVA 1XGSA 1N51A 1KQ9A 4IKSA 2BWSA 2GA2A 1WN1A 1WLRA 2BHBA 4JUQA 2GTXA 2Q94A 3L24A 1KP0A 1C23A 3L7GA 4U71A 4PNCA 2P9AA 4B28A 3IG4A 5CDVA 1WKMA 4U76A 1O0XA 4U6WA 3BIPA 4A6VA 1W7VA 3CB5A 2EVCA 4IKTA 4U1BA 4S2TP 4FLJA 2BWYA 3PKEA 1XNZA 4U6CA 2IW2A 2GU5A 1C22A 1PV9A 1YW8A 4IF7A 4EGEA 1YW9A 2Q93A 2OAZA 4U73A 4IU6A 1R5HA 2B3KA 2EA4A 2Q95A 4S2RP 2BWVA 2GG5A 4S01A 1XGMA 3IU7A 3PKDA 2BHDA 4FLIA 4U6ZA 2EA2A 2GZ5A 1BN5A 3IU8A 2BWTA 4RZZA 4R60A 2BHCA 2V3ZA 2EVMA 4IKRA 1KQ0A 1B6AA 2BWUA 4IECA 2B3HA 4RGZ1 2GGBA 4ZWUA 2GGCA 3BITA 3PKCA 2GG9A 1R5GA 4FUKA 1BOAA 2Q8KA 5CNXA 4OOKA 4QR8A 3S6BA 2G6PA 5CIKA 2GG8A 2GG3A 5D6FA 1C27A 4Z7MA 1XGNA 2GU6A 2HOWA 4PV4A 1QXYA 5D6EA 2GG0A 4FKCA 3RVAA 2B3LA 2V6CA 4FLLA 3TB5A 2GG7A 3MR1A 5FCFA 1JAWA 2GU7A 3PKBA 2NQ6A 4ZWOA 2EVOA 2P99A 3MX6A 4FO7A 2Q96A 2Q92A 1B59A 1R58A 1YJ3A 3MATA 3CTZA 3Q6DA 5JHUA 3FM3A 2OKNA 4U75A 5JFRA 4MATA 2BB7A
chains in the Genus database with same CATH superfamily
3BIQA 2BWXA 2BN7A 3RORA 2DFIA 4S00A 4HXXA 2MATA 2V3YA 4RZYA 1CHMA 4ZNGA 4IKUA 1QXWA 1M35A 1MATA 1QZYA 4U70A 5FCHA 3CB6A 4A6WA 4IDYA 1C21A 4KM3A 1XGOA 3D27A 3PKAA 4U69A 4U6EA 1A16A 1YW7A 1WBQA 2ADUA 3IU9A 2GU4A 1W2MA 2GG2A 2BWWA 2NQ7A 5E5BA 1Y1NA 4FLKA 2V3XA 1C24A 1WL6A 3FMRA 4FO8A 5CDEA 5CDLA 5JI6A 3FMQA 5CE6A 2ZSGA 2P98A 4ZWPA 1WY2A 4IPAA 1QXZA 4U6JA 2BHAA 1YVMA 5CLSA 1WL9A 2BH3A 3TAVA 1XGSA 1N51A 1KQ9A 4IKSA 2BWSA 2GA2A 1WN1A 1WLRA 2BHBA 4JUQA 2GTXA 2Q94A 3L24A 1KP0A 1C23A 3L7GA 4U71A 4PNCA 2P9AA 4B28A 3IG4A 5CDVA 1WKMA 4U76A 1O0XA 4U6WA 3BIPA 4A6VA 1W7VA 3CB5A 2EVCA 4IKTA 4U1BA 4S2TP 4FLJA 2BWYA 3PKEA 1XNZA 4U6CA 2IW2A 2GU5A 1C22A 1PV9A 1YW8A 4IF7A 4EGEA 1YW9A 2Q93A 2OAZA 4U73A 4IU6A 1R5HA 2B3KA 2EA4A 2Q95A 4S2RP 2BWVA 2GG5A 4S01A 1XGMA 3IU7A 3PKDA 2BHDA 4FLIA 4U6ZA 2EA2A 2GZ5A 1BN5A 3IU8A 2BWTA 4RZZA 4R60A 2BHCA 2V3ZA 2EVMA 4IKRA 1KQ0A 1B6AA 2BWUA 4IECA 2B3HA 4RGZ1 2GGBA 4ZWUA 2GGCA 3BITA 3PKCA 2GG9A 1R5GA 4FUKA 1BOAA 2Q8KA 5CNXA 4OOKA 4QR8A 3S6BA 2G6PA 5CIKA 2GG8A 2GG3A 5D6FA 1C27A 4Z7MA 1XGNA 2GU6A 2HOWA 4PV4A 1QXYA 5D6EA 2GG0A 4FKCA 3RVAA 2B3LA 2V6CA 4FLLA 3TB5A 2GG7A 3MR1A 5FCFA 1JAWA 2GU7A 3PKBA 2NQ6A 4ZWOA 2EVOA 2P99A 3MX6A 4FO7A 2Q96A 2Q92A 1B59A 1R58A 1YJ3A 3MATA 3CTZA 3Q6DA 5JHUA 3FM3A 2OKNA 4U75A 5JFRA 4MATA 2BB7A
chains in the Genus database with same CATH topology
3BIQA 2BWXA 2BN7A 3RORA 2DFIA 4S00A 4HXXA 2MATA 2V3YA 4RZYA 1CHMA 4ZNGA 4IKUA 1QXWA 1M35A 1MATA 1QZYA 4U70A 5FCHA 3CB6A 4A6WA 4IDYA 1C21A 4KM3A 1XGOA 3D27A 3PKAA 4U69A 4U6EA 1A16A 1YW7A 1WBQA 2ADUA 3IU9A 2GU4A 1W2MA 2GG2A 2BWWA 2NQ7A 5E5BA 1Y1NA 4FLKA 2V3XA 1C24A 1WL6A 3FMRA 4FO8A 5CDEA 5CDLA 5JI6A 3FMQA 5CE6A 2ZSGA 2P98A 4ZWPA 1WY2A 4IPAA 1QXZA 4U6JA 2BHAA 1YVMA 5CLSA 1WL9A 2BH3A 3TAVA 1XGSA 1N51A 1KQ9A 4IKSA 2BWSA 2GA2A 1WN1A 1WLRA 2BHBA 4JUQA 2GTXA 2Q94A 3L24A 1KP0A 1C23A 3L7GA 4U71A 4PNCA 2P9AA 4B28A 3IG4A 5CDVA 1WKMA 4U76A 1O0XA 4U6WA 3BIPA 4A6VA 1W7VA 3CB5A 2EVCA 4IKTA 4U1BA 4S2TP 4FLJA 2BWYA 3PKEA 1XNZA 4U6CA 2IW2A 2GU5A 1C22A 1PV9A 1YW8A 4IF7A 4EGEA 1YW9A 2Q93A 2OAZA 4U73A 4IU6A 1R5HA 2B3KA 2EA4A 2Q95A 4S2RP 2BWVA 2GG5A 4S01A 1XGMA 3IU7A 3PKDA 2BHDA 4FLIA 4U6ZA 2EA2A 2GZ5A 1BN5A 3IU8A 2BWTA 4RZZA 4R60A 2BHCA 2V3ZA 2EVMA 4IKRA 1KQ0A 1B6AA 2BWUA 4IECA 2B3HA 4RGZ1 2GGBA 4ZWUA 2GGCA 3BITA 3PKCA 2GG9A 1R5GA 4FUKA 1BOAA 2Q8KA 5CNXA 4OOKA 4QR8A 3S6BA 2G6PA 5CIKA 2GG8A 2GG3A 5D6FA 1C27A 4Z7MA 1XGNA 2GU6A 2HOWA 4PV4A 1QXYA 5D6EA 2GG0A 4FKCA 3RVAA 2B3LA 2V6CA 4FLLA 3TB5A 2GG7A 3MR1A 5FCFA 1JAWA 2GU7A 3PKBA 2NQ6A 4ZWOA 2EVOA 2P99A 3MX6A 4FO7A 2Q96A 2Q92A 1B59A 1R58A 1YJ3A 3MATA 3CTZA 3Q6DA 5JHUA 3FM3A 2OKNA 4U75A 5JFRA 4MATA 2BB7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3BIQ A;  2BWX A;  2BN7 A;  3ROR A;  2DFI A;  4S00 A;  4HXX A;  2MAT A;  2V3Y A;  4RZY A;  1CHM A;  4ZNG A;  4IKU A;  1QXW A;  1M35 A;  1MAT A;  1QZY A;  4U70 A;  5FCH A;  3CB6 A;  4A6W A;  4IDY A;  1C21 A;  4KM3 A;  1XGO A;  3D27 A;  3PKA A;  4U69 A;  4U6E A;  1A16 A;  1YW7 A;  1WBQ A;  2ADU A;  3IU9 A;  2GU4 A;  1W2M A;  2GG2 A;  2BWW A;  2NQ7 A;  5E5B A;  1Y1N A;  4FLK A;  2V3X A;  1C24 A;  1WL6 A;  3FMR A;  4FO8 A;  5CDE A;  5CDL A;  5JI6 A;  3FMQ A;  5CE6 A;  2ZSG A;  2P98 A;  4ZWP A;  1WY2 A;  4IPA A;  1QXZ A;  4U6J A;  2BHA A;  1YVM A;  5CLS A;  1WL9 A;  2BH3 A;  3TAV A;  1XGS A;  1N51 A;  1KQ9 A;  4IKS A;  2BWS A;  2GA2 A;  1WN1 A;  1WLR A;  2BHB A;  4JUQ A;  2GTX A;  2Q94 A;  3L24 A;  1KP0 A;  1C23 A;  3L7G A;  4U71 A;  4PNC A;  2P9A A;  4B28 A;  3IG4 A;  5CDV A;  1WKM A;  4U76 A;  1O0X A;  4U6W A;  3BIP A;  4A6V A;  1W7V A;  3CB5 A;  2EVC A;  4IKT A;  4U1B A;  4S2T P;  4FLJ A;  2BWY A;  3PKE A;  1XNZ A;  4U6C A;  2IW2 A;  2GU5 A;  1C22 A;  1PV9 A;  1YW8 A;  4IF7 A;  4EGE A;  1YW9 A;  2Q93 A;  2OAZ A;  4U73 A;  4IU6 A;  1R5H A;  2B3K A;  2EA4 A;  2Q95 A;  4S2R P;  2BWV A;  2GG5 A;  4S01 A;  1XGM A;  3IU7 A;  3PKD A;  2BHD A;  4FLI A;  4U6Z A;  2EA2 A;  2GZ5 A;  1BN5 A;  3IU8 A;  2BWT A;  4RZZ A;  4R60 A;  2BHC A;  2V3Z A;  2EVM A;  4IKR A;  1KQ0 A;  1B6A A;  2BWU A;  4IEC A;  2B3H A;  4RGZ 1;  2GGB A;  4ZWU A;  2GGC A;  3BIT A;  3PKC A;  2GG9 A;  1R5G A;  4FUK A;  1BOA A;  2Q8K A;  5CNX A;  4OOK A;  4QR8 A;  3S6B A;  2G6P A;  5CIK A;  2GG8 A;  2GG3 A;  5D6F A;  1C27 A;  4Z7M A;  1XGN A;  2GU6 A;  2HOW A;  4PV4 A;  1QXY A;  5D6E A;  2GG0 A;  4FKC A;  3RVA A;  2B3L A;  2V6C A;  4FLL A;  3TB5 A;  2GG7 A;  3MR1 A;  5FCF A;  1JAW A;  2GU7 A;  3PKB A;  2NQ6 A;  4ZWO A;  2EVO A;  2P99 A;  3MX6 A;  4FO7 A;  2Q96 A;  2Q92 A;  1B59 A;  1R58 A;  1YJ3 A;  3MAT A;  3CTZ A;  3Q6D A;  5JHU A;  3FM3 A;  2OKN A;  4U75 A;  5JFR A;  4MAT A;  2BB7 A; 
#chains in the Genus database with same CATH topology
 3BIQ A;  2BWX A;  2BN7 A;  3ROR A;  2DFI A;  4S00 A;  4HXX A;  2MAT A;  2V3Y A;  4RZY A;  1CHM A;  4ZNG A;  4IKU A;  1QXW A;  1M35 A;  1MAT A;  1QZY A;  4U70 A;  5FCH A;  3CB6 A;  4A6W A;  4IDY A;  1C21 A;  4KM3 A;  1XGO A;  3D27 A;  3PKA A;  4U69 A;  4U6E A;  1A16 A;  1YW7 A;  1WBQ A;  2ADU A;  3IU9 A;  2GU4 A;  1W2M A;  2GG2 A;  2BWW A;  2NQ7 A;  5E5B A;  1Y1N A;  4FLK A;  2V3X A;  1C24 A;  1WL6 A;  3FMR A;  4FO8 A;  5CDE A;  5CDL A;  5JI6 A;  3FMQ A;  5CE6 A;  2ZSG A;  2P98 A;  4ZWP A;  1WY2 A;  4IPA A;  1QXZ A;  4U6J A;  2BHA A;  1YVM A;  5CLS A;  1WL9 A;  2BH3 A;  3TAV A;  1XGS A;  1N51 A;  1KQ9 A;  4IKS A;  2BWS A;  2GA2 A;  1WN1 A;  1WLR A;  2BHB A;  4JUQ A;  2GTX A;  2Q94 A;  3L24 A;  1KP0 A;  1C23 A;  3L7G A;  4U71 A;  4PNC A;  2P9A A;  4B28 A;  3IG4 A;  5CDV A;  1WKM A;  4U76 A;  1O0X A;  4U6W A;  3BIP A;  4A6V A;  1W7V A;  3CB5 A;  2EVC A;  4IKT A;  4U1B A;  4S2T P;  4FLJ A;  2BWY A;  3PKE A;  1XNZ A;  4U6C A;  2IW2 A;  2GU5 A;  1C22 A;  1PV9 A;  1YW8 A;  4IF7 A;  4EGE A;  1YW9 A;  2Q93 A;  2OAZ A;  4U73 A;  4IU6 A;  1R5H A;  2B3K A;  2EA4 A;  2Q95 A;  4S2R P;  2BWV A;  2GG5 A;  4S01 A;  1XGM A;  3IU7 A;  3PKD A;  2BHD A;  4FLI A;  4U6Z A;  2EA2 A;  2GZ5 A;  1BN5 A;  3IU8 A;  2BWT A;  4RZZ A;  4R60 A;  2BHC A;  2V3Z A;  2EVM A;  4IKR A;  1KQ0 A;  1B6A A;  2BWU A;  4IEC A;  2B3H A;  4RGZ 1;  2GGB A;  4ZWU A;  2GGC A;  3BIT A;  3PKC A;  2GG9 A;  1R5G A;  4FUK A;  1BOA A;  2Q8K A;  5CNX A;  4OOK A;  4QR8 A;  3S6B A;  2G6P A;  5CIK A;  2GG8 A;  2GG3 A;  5D6F A;  1C27 A;  4Z7M A;  1XGN A;  2GU6 A;  2HOW A;  4PV4 A;  1QXY A;  5D6E A;  2GG0 A;  4FKC A;  3RVA A;  2B3L A;  2V6C A;  4FLL A;  3TB5 A;  2GG7 A;  3MR1 A;  5FCF A;  1JAW A;  2GU7 A;  3PKB A;  2NQ6 A;  4ZWO A;  2EVO A;  2P99 A;  3MX6 A;  4FO7 A;  2Q96 A;  2Q92 A;  1B59 A;  1R58 A;  1YJ3 A;  3MAT A;  3CTZ A;  3Q6D A;  5JHU A;  3FM3 A;  2OKN A;  4U75 A;  5JFR A;  4MAT A;  2BB7 A; 
#chains in the Genus database with same CATH homology
 3BIQ A;  2BWX A;  2BN7 A;  3ROR A;  2DFI A;  4S00 A;  4HXX A;  2MAT A;  2V3Y A;  4RZY A;  1CHM A;  4ZNG A;  4IKU A;  1QXW A;  1M35 A;  1MAT A;  1QZY A;  4U70 A;  5FCH A;  3CB6 A;  4A6W A;  4IDY A;  1C21 A;  4KM3 A;  1XGO A;  3D27 A;  3PKA A;  4U69 A;  4U6E A;  1A16 A;  1YW7 A;  1WBQ A;  2ADU A;  3IU9 A;  2GU4 A;  1W2M A;  2GG2 A;  2BWW A;  2NQ7 A;  5E5B A;  1Y1N A;  4FLK A;  2V3X A;  1C24 A;  1WL6 A;  3FMR A;  4FO8 A;  5CDE A;  5CDL A;  5JI6 A;  3FMQ A;  5CE6 A;  2ZSG A;  2P98 A;  4ZWP A;  1WY2 A;  4IPA A;  1QXZ A;  4U6J A;  2BHA A;  1YVM A;  5CLS A;  1WL9 A;  2BH3 A;  3TAV A;  1XGS A;  1N51 A;  1KQ9 A;  4IKS A;  2BWS A;  2GA2 A;  1WN1 A;  1WLR A;  2BHB A;  4JUQ A;  2GTX A;  2Q94 A;  3L24 A;  1KP0 A;  1C23 A;  3L7G A;  4U71 A;  4PNC A;  2P9A A;  4B28 A;  3IG4 A;  5CDV A;  1WKM A;  4U76 A;  1O0X A;  4U6W A;  3BIP A;  4A6V A;  1W7V A;  3CB5 A;  2EVC A;  4IKT A;  4U1B A;  4S2T P;  4FLJ A;  2BWY A;  3PKE A;  1XNZ A;  4U6C A;  2IW2 A;  2GU5 A;  1C22 A;  1PV9 A;  1YW8 A;  4IF7 A;  4EGE A;  1YW9 A;  2Q93 A;  2OAZ A;  4U73 A;  4IU6 A;  1R5H A;  2B3K A;  2EA4 A;  2Q95 A;  4S2R P;  2BWV A;  2GG5 A;  4S01 A;  1XGM A;  3IU7 A;  3PKD A;  2BHD A;  4FLI A;  4U6Z A;  2EA2 A;  2GZ5 A;  1BN5 A;  3IU8 A;  2BWT A;  4RZZ A;  4R60 A;  2BHC A;  2V3Z A;  2EVM A;  4IKR A;  1KQ0 A;  1B6A A;  2BWU A;  4IEC A;  2B3H A;  4RGZ 1;  2GGB A;  4ZWU A;  2GGC A;  3BIT A;  3PKC A;  2GG9 A;  1R5G A;  4FUK A;  1BOA A;  2Q8K A;  5CNX A;  4OOK A;  4QR8 A;  3S6B A;  2G6P A;  5CIK A;  2GG8 A;  2GG3 A;  5D6F A;  1C27 A;  4Z7M A;  1XGN A;  2GU6 A;  2HOW A;  4PV4 A;  1QXY A;  5D6E A;  2GG0 A;  4FKC A;  3RVA A;  2B3L A;  2V6C A;  4FLL A;  3TB5 A;  2GG7 A;  3MR1 A;  5FCF A;  1JAW A;  2GU7 A;  3PKB A;  2NQ6 A;  4ZWO A;  2EVO A;  2P99 A;  3MX6 A;  4FO7 A;  2Q96 A;  2Q92 A;  1B59 A;  1R58 A;  1YJ3 A;  3MAT A;  3CTZ A;  3Q6D A;  5JHU A;  3FM3 A;  2OKN A;  4U75 A;  5JFR A;  4MAT A;  2BB7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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