2MATA

E.coli methionine aminopeptidase at 1.9 angstrom resolution
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Escherichia coli methionine aminopeptidase: implications of crystallographic analyses of the native, mutant, and inhibited enzymes for the mechanism of catalysis.
pubmed doi rcsb
molecule tags Hydrolase
source organism Escherichia coli
molecule keywords PROTEIN (METHIONINE AMINOPEPTIDASE)
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 1999-03-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2matA00
3PKDA 4U76A 4U71A 5CNXA 4U73A 2Q95A 2BWTA 1XNZA 3PKAA 5CDVA 3S6BA 2GU4A 4FO8A 4FLIA 2GG2A 2Q8KA 4S2RP 5CIKA 4IECA 1XGOA 1Y1NA 1QXWA 2V3ZA 3IU7A 3BITA 1C21A 3MX6A 2Q94A 1YW9A 2DFIA 1WBQA 2BWYA 2GU6A 2GU7A 1C24A 1C22A 3L24A 2GG5A 2BH3A 4ZWOA 2GGBA 5CDEA 1R5GA 4ZWUA 2GA2A 3MATA 4S01A 4U6ZA 1B59A 2BHBA 2P98A 1XGSA 3MR1A 1R58A 4FLJA 2ZSGA 2GZ5A 2Q96A 1WLRA 3RORA 1BN5A 3BIQA 2MATA 4IPAA 5CLSA 5FCFA 3FM3A 1M35A 2GU5A 1MATA 2B3HA 1C27A 2NQ6A 2OAZA 4Z7MA 2BHCA 4FUKA 3PKCA 1N51A 4EGEA 4ZWPA 3IU9A 3FMRA 4U6JA 4B28A 5JI6A 1YW8A 3IG4A 1YJ3A 2HOWA 4FO7A 1KQ9A 4QR8A 4ZNGA 4RGZ1 2B3LA 1PV9A 3CTZA 2V3XA 4U6EA 4IDYA 5D6EA 4JUQA 2GG0A 4IKUA 2BHDA 1O0XA 2BWWA 4IKTA 4U6WA 4U69A 1QXYA 4R60A 1XGNA 1B6AA 2NQ7A 2EA4A 1A16A 2GGCA 2GG8A 4A6WA 2ADUA 2EVCA 4KM3A 5E5BA 4FKCA 3CB5A 3D27A 1QZYA 5FCHA 4S00A 2GG7A 4IF7A 1BOAA 2GTXA 1WY2A 4RZZA 5D6FA 2BWSA 3Q6DA 1WN1A 1KP0A 3CB6A 4U75A 1CHMA 2BHAA 5JHUA 3RVAA 4A6VA 2EVMA 4MATA 2BWVA 1R5HA 2EA2A 1WKMA 4S2TP 2V3YA 2BB7A 4PV4A 2BWXA 1W7VA 1YW7A 2IW2A 3BIPA 2Q93A 1WL9A 3L7GA 2P99A 2GG3A 2GG9A 4U1BA 3IU8A 1XGMA 4FLKA 1W2MA 4U6CA 4HXXA 3TAVA 1YVMA 3PKEA 2EVOA 2BN7A 1WL6A 4RZYA 1KQ0A 2Q92A 4IKRA 1JAWA 5CDLA 2V6CA 1QXZA 2OKNA 4IU6A 4OOKA 3TB5A 5CE6A 1C23A 4IKSA 2B3KA 2BWUA 4PNCA 2P9AA 5JFRA 3PKBA 2G6PA 4FLLA 4U70A 3FMQA
chains in the Genus database with same CATH superfamily
3PKDA 4U76A 4U71A 5CNXA 4U73A 2Q95A 2BWTA 1XNZA 3PKAA 5CDVA 3S6BA 2GU4A 4FO8A 4FLIA 2GG2A 2Q8KA 4S2RP 5CIKA 4IECA 1XGOA 1Y1NA 1QXWA 2V3ZA 3IU7A 3BITA 1C21A 3MX6A 2Q94A 1YW9A 2DFIA 1WBQA 2BWYA 2GU6A 2GU7A 1C24A 1C22A 3L24A 2GG5A 2BH3A 4ZWOA 2GGBA 5CDEA 1R5GA 4ZWUA 2GA2A 3MATA 4S01A 4U6ZA 1B59A 2BHBA 2P98A 1XGSA 3MR1A 1R58A 4FLJA 2ZSGA 2GZ5A 2Q96A 1WLRA 3RORA 1BN5A 3BIQA 2MATA 4IPAA 5CLSA 5FCFA 3FM3A 1M35A 2GU5A 1MATA 2B3HA 1C27A 2NQ6A 2OAZA 4Z7MA 2BHCA 4FUKA 3PKCA 1N51A 4EGEA 4ZWPA 3IU9A 3FMRA 4U6JA 4B28A 5JI6A 1YW8A 3IG4A 1YJ3A 2HOWA 4FO7A 1KQ9A 4QR8A 4ZNGA 4RGZ1 2B3LA 1PV9A 3CTZA 2V3XA 4U6EA 4IDYA 5D6EA 4JUQA 2GG0A 4IKUA 2BHDA 1O0XA 2BWWA 4IKTA 4U6WA 4U69A 1QXYA 4R60A 1XGNA 1B6AA 2NQ7A 2EA4A 1A16A 2GGCA 2GG8A 4A6WA 2ADUA 2EVCA 4KM3A 5E5BA 4FKCA 3CB5A 3D27A 1QZYA 5FCHA 4S00A 2GG7A 4IF7A 1BOAA 2GTXA 1WY2A 4RZZA 5D6FA 2BWSA 3Q6DA 1WN1A 1KP0A 3CB6A 4U75A 1CHMA 2BHAA 5JHUA 3RVAA 4A6VA 2EVMA 4MATA 2BWVA 1R5HA 2EA2A 1WKMA 4S2TP 2V3YA 2BB7A 4PV4A 2BWXA 1W7VA 1YW7A 2IW2A 3BIPA 2Q93A 1WL9A 3L7GA 2P99A 2GG3A 2GG9A 4U1BA 3IU8A 1XGMA 4FLKA 1W2MA 4U6CA 4HXXA 3TAVA 1YVMA 3PKEA 2EVOA 2BN7A 1WL6A 4RZYA 1KQ0A 2Q92A 4IKRA 1JAWA 5CDLA 2V6CA 1QXZA 2OKNA 4IU6A 4OOKA 3TB5A 5CE6A 1C23A 4IKSA 2B3KA 2BWUA 4PNCA 2P9AA 5JFRA 3PKBA 2G6PA 4FLLA 4U70A 3FMQA
chains in the Genus database with same CATH topology
3PKDA 4U76A 4U71A 5CNXA 4U73A 2Q95A 2BWTA 1XNZA 3PKAA 5CDVA 3S6BA 2GU4A 4FO8A 4FLIA 2GG2A 2Q8KA 4S2RP 5CIKA 4IECA 1XGOA 1Y1NA 1QXWA 2V3ZA 3IU7A 3BITA 1C21A 3MX6A 2Q94A 1YW9A 2DFIA 1WBQA 2BWYA 2GU6A 2GU7A 1C24A 1C22A 3L24A 2GG5A 2BH3A 4ZWOA 2GGBA 5CDEA 1R5GA 4ZWUA 2GA2A 3MATA 4S01A 4U6ZA 1B59A 2BHBA 2P98A 1XGSA 3MR1A 1R58A 4FLJA 2ZSGA 2GZ5A 2Q96A 1WLRA 3RORA 1BN5A 3BIQA 2MATA 4IPAA 5CLSA 5FCFA 3FM3A 1M35A 2GU5A 1MATA 2B3HA 1C27A 2NQ6A 2OAZA 4Z7MA 2BHCA 4FUKA 3PKCA 1N51A 4EGEA 4ZWPA 3IU9A 3FMRA 4U6JA 4B28A 5JI6A 1YW8A 3IG4A 1YJ3A 2HOWA 4FO7A 1KQ9A 4QR8A 4ZNGA 4RGZ1 2B3LA 1PV9A 3CTZA 2V3XA 4U6EA 4IDYA 5D6EA 4JUQA 2GG0A 4IKUA 2BHDA 1O0XA 2BWWA 4IKTA 4U6WA 4U69A 1QXYA 4R60A 1XGNA 1B6AA 2NQ7A 2EA4A 1A16A 2GGCA 2GG8A 4A6WA 2ADUA 2EVCA 4KM3A 5E5BA 4FKCA 3CB5A 3D27A 1QZYA 5FCHA 4S00A 2GG7A 4IF7A 1BOAA 2GTXA 1WY2A 4RZZA 5D6FA 2BWSA 3Q6DA 1WN1A 1KP0A 3CB6A 4U75A 1CHMA 2BHAA 5JHUA 3RVAA 4A6VA 2EVMA 4MATA 2BWVA 1R5HA 2EA2A 1WKMA 4S2TP 2V3YA 2BB7A 4PV4A 2BWXA 1W7VA 1YW7A 2IW2A 3BIPA 2Q93A 1WL9A 3L7GA 2P99A 2GG3A 2GG9A 4U1BA 3IU8A 1XGMA 4FLKA 1W2MA 4U6CA 4HXXA 3TAVA 1YVMA 3PKEA 2EVOA 2BN7A 1WL6A 4RZYA 1KQ0A 2Q92A 4IKRA 1JAWA 5CDLA 2V6CA 1QXZA 2OKNA 4IU6A 4OOKA 3TB5A 5CE6A 1C23A 4IKSA 2B3KA 2BWUA 4PNCA 2P9AA 5JFRA 3PKBA 2G6PA 4FLLA 4U70A 3FMQA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3PKD A;  4U76 A;  4U71 A;  5CNX A;  4U73 A;  2Q95 A;  2BWT A;  1XNZ A;  3PKA A;  5CDV A;  3S6B A;  2GU4 A;  4FO8 A;  4FLI A;  2GG2 A;  2Q8K A;  4S2R P;  5CIK A;  4IEC A;  1XGO A;  1Y1N A;  1QXW A;  2V3Z A;  3IU7 A;  3BIT A;  1C21 A;  3MX6 A;  2Q94 A;  1YW9 A;  2DFI A;  1WBQ A;  2BWY A;  2GU6 A;  2GU7 A;  1C24 A;  1C22 A;  3L24 A;  2GG5 A;  2BH3 A;  4ZWO A;  2GGB A;  5CDE A;  1R5G A;  4ZWU A;  2GA2 A;  3MAT A;  4S01 A;  4U6Z A;  1B59 A;  2BHB A;  2P98 A;  1XGS A;  3MR1 A;  1R58 A;  4FLJ A;  2ZSG A;  2GZ5 A;  2Q96 A;  1WLR A;  3ROR A;  1BN5 A;  3BIQ A;  2MAT A;  4IPA A;  5CLS A;  5FCF A;  3FM3 A;  1M35 A;  2GU5 A;  1MAT A;  2B3H A;  1C27 A;  2NQ6 A;  2OAZ A;  4Z7M A;  2BHC A;  4FUK A;  3PKC A;  1N51 A;  4EGE A;  4ZWP A;  3IU9 A;  3FMR A;  4U6J A;  4B28 A;  5JI6 A;  1YW8 A;  3IG4 A;  1YJ3 A;  2HOW A;  4FO7 A;  1KQ9 A;  4QR8 A;  4ZNG A;  4RGZ 1;  2B3L A;  1PV9 A;  3CTZ A;  2V3X A;  4U6E A;  4IDY A;  5D6E A;  4JUQ A;  2GG0 A;  4IKU A;  2BHD A;  1O0X A;  2BWW A;  4IKT A;  4U6W A;  4U69 A;  1QXY A;  4R60 A;  1XGN A;  1B6A A;  2NQ7 A;  2EA4 A;  1A16 A;  2GGC A;  2GG8 A;  4A6W A;  2ADU A;  2EVC A;  4KM3 A;  5E5B A;  4FKC A;  3CB5 A;  3D27 A;  1QZY A;  5FCH A;  4S00 A;  2GG7 A;  4IF7 A;  1BOA A;  2GTX A;  1WY2 A;  4RZZ A;  5D6F A;  2BWS A;  3Q6D A;  1WN1 A;  1KP0 A;  3CB6 A;  4U75 A;  1CHM A;  2BHA A;  5JHU A;  3RVA A;  4A6V A;  2EVM A;  4MAT A;  2BWV A;  1R5H A;  2EA2 A;  1WKM A;  4S2T P;  2V3Y A;  2BB7 A;  4PV4 A;  2BWX A;  1W7V A;  1YW7 A;  2IW2 A;  3BIP A;  2Q93 A;  1WL9 A;  3L7G A;  2P99 A;  2GG3 A;  2GG9 A;  4U1B A;  3IU8 A;  1XGM A;  4FLK A;  1W2M A;  4U6C A;  4HXX A;  3TAV A;  1YVM A;  3PKE A;  2EVO A;  2BN7 A;  1WL6 A;  4RZY A;  1KQ0 A;  2Q92 A;  4IKR A;  1JAW A;  5CDL A;  2V6C A;  1QXZ A;  2OKN A;  4IU6 A;  4OOK A;  3TB5 A;  5CE6 A;  1C23 A;  4IKS A;  2B3K A;  2BWU A;  4PNC A;  2P9A A;  5JFR A;  3PKB A;  2G6P A;  4FLL A;  4U70 A;  3FMQ A; 
#chains in the Genus database with same CATH topology
 3PKD A;  4U76 A;  4U71 A;  5CNX A;  4U73 A;  2Q95 A;  2BWT A;  1XNZ A;  3PKA A;  5CDV A;  3S6B A;  2GU4 A;  4FO8 A;  4FLI A;  2GG2 A;  2Q8K A;  4S2R P;  5CIK A;  4IEC A;  1XGO A;  1Y1N A;  1QXW A;  2V3Z A;  3IU7 A;  3BIT A;  1C21 A;  3MX6 A;  2Q94 A;  1YW9 A;  2DFI A;  1WBQ A;  2BWY A;  2GU6 A;  2GU7 A;  1C24 A;  1C22 A;  3L24 A;  2GG5 A;  2BH3 A;  4ZWO A;  2GGB A;  5CDE A;  1R5G A;  4ZWU A;  2GA2 A;  3MAT A;  4S01 A;  4U6Z A;  1B59 A;  2BHB A;  2P98 A;  1XGS A;  3MR1 A;  1R58 A;  4FLJ A;  2ZSG A;  2GZ5 A;  2Q96 A;  1WLR A;  3ROR A;  1BN5 A;  3BIQ A;  2MAT A;  4IPA A;  5CLS A;  5FCF A;  3FM3 A;  1M35 A;  2GU5 A;  1MAT A;  2B3H A;  1C27 A;  2NQ6 A;  2OAZ A;  4Z7M A;  2BHC A;  4FUK A;  3PKC A;  1N51 A;  4EGE A;  4ZWP A;  3IU9 A;  3FMR A;  4U6J A;  4B28 A;  5JI6 A;  1YW8 A;  3IG4 A;  1YJ3 A;  2HOW A;  4FO7 A;  1KQ9 A;  4QR8 A;  4ZNG A;  4RGZ 1;  2B3L A;  1PV9 A;  3CTZ A;  2V3X A;  4U6E A;  4IDY A;  5D6E A;  4JUQ A;  2GG0 A;  4IKU A;  2BHD A;  1O0X A;  2BWW A;  4IKT A;  4U6W A;  4U69 A;  1QXY A;  4R60 A;  1XGN A;  1B6A A;  2NQ7 A;  2EA4 A;  1A16 A;  2GGC A;  2GG8 A;  4A6W A;  2ADU A;  2EVC A;  4KM3 A;  5E5B A;  4FKC A;  3CB5 A;  3D27 A;  1QZY A;  5FCH A;  4S00 A;  2GG7 A;  4IF7 A;  1BOA A;  2GTX A;  1WY2 A;  4RZZ A;  5D6F A;  2BWS A;  3Q6D A;  1WN1 A;  1KP0 A;  3CB6 A;  4U75 A;  1CHM A;  2BHA A;  5JHU A;  3RVA A;  4A6V A;  2EVM A;  4MAT A;  2BWV A;  1R5H A;  2EA2 A;  1WKM A;  4S2T P;  2V3Y A;  2BB7 A;  4PV4 A;  2BWX A;  1W7V A;  1YW7 A;  2IW2 A;  3BIP A;  2Q93 A;  1WL9 A;  3L7G A;  2P99 A;  2GG3 A;  2GG9 A;  4U1B A;  3IU8 A;  1XGM A;  4FLK A;  1W2M A;  4U6C A;  4HXX A;  3TAV A;  1YVM A;  3PKE A;  2EVO A;  2BN7 A;  1WL6 A;  4RZY A;  1KQ0 A;  2Q92 A;  4IKR A;  1JAW A;  5CDL A;  2V6C A;  1QXZ A;  2OKN A;  4IU6 A;  4OOK A;  3TB5 A;  5CE6 A;  1C23 A;  4IKS A;  2B3K A;  2BWU A;  4PNC A;  2P9A A;  5JFR A;  3PKB A;  2G6P A;  4FLL A;  4U70 A;  3FMQ A; 
#chains in the Genus database with same CATH homology
 3PKD A;  4U76 A;  4U71 A;  5CNX A;  4U73 A;  2Q95 A;  2BWT A;  1XNZ A;  3PKA A;  5CDV A;  3S6B A;  2GU4 A;  4FO8 A;  4FLI A;  2GG2 A;  2Q8K A;  4S2R P;  5CIK A;  4IEC A;  1XGO A;  1Y1N A;  1QXW A;  2V3Z A;  3IU7 A;  3BIT A;  1C21 A;  3MX6 A;  2Q94 A;  1YW9 A;  2DFI A;  1WBQ A;  2BWY A;  2GU6 A;  2GU7 A;  1C24 A;  1C22 A;  3L24 A;  2GG5 A;  2BH3 A;  4ZWO A;  2GGB A;  5CDE A;  1R5G A;  4ZWU A;  2GA2 A;  3MAT A;  4S01 A;  4U6Z A;  1B59 A;  2BHB A;  2P98 A;  1XGS A;  3MR1 A;  1R58 A;  4FLJ A;  2ZSG A;  2GZ5 A;  2Q96 A;  1WLR A;  3ROR A;  1BN5 A;  3BIQ A;  2MAT A;  4IPA A;  5CLS A;  5FCF A;  3FM3 A;  1M35 A;  2GU5 A;  1MAT A;  2B3H A;  1C27 A;  2NQ6 A;  2OAZ A;  4Z7M A;  2BHC A;  4FUK A;  3PKC A;  1N51 A;  4EGE A;  4ZWP A;  3IU9 A;  3FMR A;  4U6J A;  4B28 A;  5JI6 A;  1YW8 A;  3IG4 A;  1YJ3 A;  2HOW A;  4FO7 A;  1KQ9 A;  4QR8 A;  4ZNG A;  4RGZ 1;  2B3L A;  1PV9 A;  3CTZ A;  2V3X A;  4U6E A;  4IDY A;  5D6E A;  4JUQ A;  2GG0 A;  4IKU A;  2BHD A;  1O0X A;  2BWW A;  4IKT A;  4U6W A;  4U69 A;  1QXY A;  4R60 A;  1XGN A;  1B6A A;  2NQ7 A;  2EA4 A;  1A16 A;  2GGC A;  2GG8 A;  4A6W A;  2ADU A;  2EVC A;  4KM3 A;  5E5B A;  4FKC A;  3CB5 A;  3D27 A;  1QZY A;  5FCH A;  4S00 A;  2GG7 A;  4IF7 A;  1BOA A;  2GTX A;  1WY2 A;  4RZZ A;  5D6F A;  2BWS A;  3Q6D A;  1WN1 A;  1KP0 A;  3CB6 A;  4U75 A;  1CHM A;  2BHA A;  5JHU A;  3RVA A;  4A6V A;  2EVM A;  4MAT A;  2BWV A;  1R5H A;  2EA2 A;  1WKM A;  4S2T P;  2V3Y A;  2BB7 A;  4PV4 A;  2BWX A;  1W7V A;  1YW7 A;  2IW2 A;  3BIP A;  2Q93 A;  1WL9 A;  3L7G A;  2P99 A;  2GG3 A;  2GG9 A;  4U1B A;  3IU8 A;  1XGM A;  4FLK A;  1W2M A;  4U6C A;  4HXX A;  3TAV A;  1YVM A;  3PKE A;  2EVO A;  2BN7 A;  1WL6 A;  4RZY A;  1KQ0 A;  2Q92 A;  4IKR A;  1JAW A;  5CDL A;  2V6C A;  1QXZ A;  2OKN A;  4IU6 A;  4OOK A;  3TB5 A;  5CE6 A;  1C23 A;  4IKS A;  2B3K A;  2BWU A;  4PNC A;  2P9A A;  5JFR A;  3PKB A;  2G6P A;  4FLL A;  4U70 A;  3FMQ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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