2NQ7A

Crystal structure of type 1 human methionine aminopeptidase in complex with 3-(2,2-dimethylpropionylamino)pyridine-2-carboxylic acid thiazole-2-ylamide
Total Genus 101
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression.
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2006-10-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2nq7A00
2BHAA 1BN5A 1BOAA 3PKBA 1C24A 1KQ0A 2V3ZA 1WN1A 4FLIA 4B28A 2EVOA 2OAZA 3BIQA 4IPAA 4ZWPA 1Y1NA 2EA2A 4IKRA 4ZWOA 5CDVA 4FO7A 2G6PA 2GGBA 5JHUA 2EVMA 1MATA 4S00A 2GG3A 4FKCA 4U6ZA 5E5BA 2EVCA 2GZ5A 2BWXA 4IF7A 3MATA 2GG0A 2B3LA 2BHBA 1JAWA 1YW7A 2GGCA 2GA2A 4FUKA 5D6FA 2B3HA 3MX6A 3PKAA 3L24A 4RZZA 4U6JA 2OKNA 4IKSA 1YW9A 3PKDA 1KQ9A 1B6AA 1YVMA 4U69A 5D6EA 4U6EA 2GU7A 2BWVA 3PKCA 1QXWA 1C22A 2GG5A 3IU9A 1C23A 1PV9A 3IU7A 2BHCA 4U1BA 4Z7MA 1C21A 3CB5A 4ZNGA 4IKTA 4S2TP 5FCFA 2P98A 3FM3A 3FMRA 4QR8A 3S6BA 1WKMA 2Q92A 3PKEA 5CNXA 5CDEA 1KP0A 4FLKA 4U70A 4EGEA 1XNZA 1C27A 2NQ6A 3MR1A 4FLJA 4S01A 3IU8A 4U71A 1WL6A 1N51A 1W2MA 3L7GA 4IU6A 4HXXA 1XGNA 4IKUA 4A6WA 3TAVA 2BWTA 1QZYA 2V6CA 4U73A 1YJ3A 2GU5A 4KM3A 1XGOA 2Q94A 2B3KA 1WLRA 1W7VA 2P99A 2BWSA 4U75A 2Q95A 1WY2A 3Q6DA 1WL9A 1QXYA 4IECA 1YW8A 2BWUA 4ZWUA 4FO8A 2GG2A 2BWWA 4R60A 4RZYA 5CLSA 2GU6A 2MATA 1WBQA 1QXZA 2GG9A 1R58A 4OOKA 4U6WA 2IW2A 3FMQA 4PNCA 4MATA 4JUQA 1XGMA 3CTZA 4IDYA 2BN7A 4RGZ1 4PV4A 5CDLA 2ADUA 1XGSA 5FCHA 2V3YA 3IG4A 3RORA 2BH3A 4S2RP 2EA4A 5CE6A 2BWYA 4A6VA 1R5GA 2Q96A 5CIKA 1O0XA 3TB5A 2Q8KA 3BIPA 3CB6A 3RVAA 4U6CA 1CHMA 1R5HA 2GTXA 2DFIA 2NQ7A 2ZSGA 2GU4A 2HOWA 3BITA 2GG7A 2V3XA 1B59A 1M35A 2P9AA 5JI6A 2BHDA 1A16A 3D27A 2Q93A 2BB7A 4FLLA 2GG8A 5JFRA 4U76A
chains in the Genus database with same CATH superfamily
2BHAA 1BN5A 1BOAA 3PKBA 1C24A 1KQ0A 2V3ZA 1WN1A 4FLIA 4B28A 2EVOA 2OAZA 3BIQA 4IPAA 4ZWPA 1Y1NA 2EA2A 4IKRA 4ZWOA 5CDVA 4FO7A 2G6PA 2GGBA 5JHUA 2EVMA 1MATA 4S00A 2GG3A 4FKCA 4U6ZA 5E5BA 2EVCA 2GZ5A 2BWXA 4IF7A 3MATA 2GG0A 2B3LA 2BHBA 1JAWA 1YW7A 2GGCA 2GA2A 4FUKA 5D6FA 2B3HA 3MX6A 3PKAA 3L24A 4RZZA 4U6JA 2OKNA 4IKSA 1YW9A 3PKDA 1KQ9A 1B6AA 1YVMA 4U69A 5D6EA 4U6EA 2GU7A 2BWVA 3PKCA 1QXWA 1C22A 2GG5A 3IU9A 1C23A 1PV9A 3IU7A 2BHCA 4U1BA 4Z7MA 1C21A 3CB5A 4ZNGA 4IKTA 4S2TP 5FCFA 2P98A 3FM3A 3FMRA 4QR8A 3S6BA 1WKMA 2Q92A 3PKEA 5CNXA 5CDEA 1KP0A 4FLKA 4U70A 4EGEA 1XNZA 1C27A 2NQ6A 3MR1A 4FLJA 4S01A 3IU8A 4U71A 1WL6A 1N51A 1W2MA 3L7GA 4IU6A 4HXXA 1XGNA 4IKUA 4A6WA 3TAVA 2BWTA 1QZYA 2V6CA 4U73A 1YJ3A 2GU5A 4KM3A 1XGOA 2Q94A 2B3KA 1WLRA 1W7VA 2P99A 2BWSA 4U75A 2Q95A 1WY2A 3Q6DA 1WL9A 1QXYA 4IECA 1YW8A 2BWUA 4ZWUA 4FO8A 2GG2A 2BWWA 4R60A 4RZYA 5CLSA 2GU6A 2MATA 1WBQA 1QXZA 2GG9A 1R58A 4OOKA 4U6WA 2IW2A 3FMQA 4PNCA 4MATA 4JUQA 1XGMA 3CTZA 4IDYA 2BN7A 4RGZ1 4PV4A 5CDLA 2ADUA 1XGSA 5FCHA 2V3YA 3IG4A 3RORA 2BH3A 4S2RP 2EA4A 5CE6A 2BWYA 4A6VA 1R5GA 2Q96A 5CIKA 1O0XA 3TB5A 2Q8KA 3BIPA 3CB6A 3RVAA 4U6CA 1CHMA 1R5HA 2GTXA 2DFIA 2NQ7A 2ZSGA 2GU4A 2HOWA 3BITA 2GG7A 2V3XA 1B59A 1M35A 2P9AA 5JI6A 2BHDA 1A16A 3D27A 2Q93A 2BB7A 4FLLA 2GG8A 5JFRA 4U76A
chains in the Genus database with same CATH topology
2BHAA 1BN5A 1BOAA 3PKBA 1C24A 1KQ0A 2V3ZA 1WN1A 4FLIA 4B28A 2EVOA 2OAZA 3BIQA 4IPAA 4ZWPA 1Y1NA 2EA2A 4IKRA 4ZWOA 5CDVA 4FO7A 2G6PA 2GGBA 5JHUA 2EVMA 1MATA 4S00A 2GG3A 4FKCA 4U6ZA 5E5BA 2EVCA 2GZ5A 2BWXA 4IF7A 3MATA 2GG0A 2B3LA 2BHBA 1JAWA 1YW7A 2GGCA 2GA2A 4FUKA 5D6FA 2B3HA 3MX6A 3PKAA 3L24A 4RZZA 4U6JA 2OKNA 4IKSA 1YW9A 3PKDA 1KQ9A 1B6AA 1YVMA 4U69A 5D6EA 4U6EA 2GU7A 2BWVA 3PKCA 1QXWA 1C22A 2GG5A 3IU9A 1C23A 1PV9A 3IU7A 2BHCA 4U1BA 4Z7MA 1C21A 3CB5A 4ZNGA 4IKTA 4S2TP 5FCFA 2P98A 3FM3A 3FMRA 4QR8A 3S6BA 1WKMA 2Q92A 3PKEA 5CNXA 5CDEA 1KP0A 4FLKA 4U70A 4EGEA 1XNZA 1C27A 2NQ6A 3MR1A 4FLJA 4S01A 3IU8A 4U71A 1WL6A 1N51A 1W2MA 3L7GA 4IU6A 4HXXA 1XGNA 4IKUA 4A6WA 3TAVA 2BWTA 1QZYA 2V6CA 4U73A 1YJ3A 2GU5A 4KM3A 1XGOA 2Q94A 2B3KA 1WLRA 1W7VA 2P99A 2BWSA 4U75A 2Q95A 1WY2A 3Q6DA 1WL9A 1QXYA 4IECA 1YW8A 2BWUA 4ZWUA 4FO8A 2GG2A 2BWWA 4R60A 4RZYA 5CLSA 2GU6A 2MATA 1WBQA 1QXZA 2GG9A 1R58A 4OOKA 4U6WA 2IW2A 3FMQA 4PNCA 4MATA 4JUQA 1XGMA 3CTZA 4IDYA 2BN7A 4RGZ1 4PV4A 5CDLA 2ADUA 1XGSA 5FCHA 2V3YA 3IG4A 3RORA 2BH3A 4S2RP 2EA4A 5CE6A 2BWYA 4A6VA 1R5GA 2Q96A 5CIKA 1O0XA 3TB5A 2Q8KA 3BIPA 3CB6A 3RVAA 4U6CA 1CHMA 1R5HA 2GTXA 2DFIA 2NQ7A 2ZSGA 2GU4A 2HOWA 3BITA 2GG7A 2V3XA 1B59A 1M35A 2P9AA 5JI6A 2BHDA 1A16A 3D27A 2Q93A 2BB7A 4FLLA 2GG8A 5JFRA 4U76A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BHA A;  1BN5 A;  1BOA A;  3PKB A;  1C24 A;  1KQ0 A;  2V3Z A;  1WN1 A;  4FLI A;  4B28 A;  2EVO A;  2OAZ A;  3BIQ A;  4IPA A;  4ZWP A;  1Y1N A;  2EA2 A;  4IKR A;  4ZWO A;  5CDV A;  4FO7 A;  2G6P A;  2GGB A;  5JHU A;  2EVM A;  1MAT A;  4S00 A;  2GG3 A;  4FKC A;  4U6Z A;  5E5B A;  2EVC A;  2GZ5 A;  2BWX A;  4IF7 A;  3MAT A;  2GG0 A;  2B3L A;  2BHB A;  1JAW A;  1YW7 A;  2GGC A;  2GA2 A;  4FUK A;  5D6F A;  2B3H A;  3MX6 A;  3PKA A;  3L24 A;  4RZZ A;  4U6J A;  2OKN A;  4IKS A;  1YW9 A;  3PKD A;  1KQ9 A;  1B6A A;  1YVM A;  4U69 A;  5D6E A;  4U6E A;  2GU7 A;  2BWV A;  3PKC A;  1QXW A;  1C22 A;  2GG5 A;  3IU9 A;  1C23 A;  1PV9 A;  3IU7 A;  2BHC A;  4U1B A;  4Z7M A;  1C21 A;  3CB5 A;  4ZNG A;  4IKT A;  4S2T P;  5FCF A;  2P98 A;  3FM3 A;  3FMR A;  4QR8 A;  3S6B A;  1WKM A;  2Q92 A;  3PKE A;  5CNX A;  5CDE A;  1KP0 A;  4FLK A;  4U70 A;  4EGE A;  1XNZ A;  1C27 A;  2NQ6 A;  3MR1 A;  4FLJ A;  4S01 A;  3IU8 A;  4U71 A;  1WL6 A;  1N51 A;  1W2M A;  3L7G A;  4IU6 A;  4HXX A;  1XGN A;  4IKU A;  4A6W A;  3TAV A;  2BWT A;  1QZY A;  2V6C A;  4U73 A;  1YJ3 A;  2GU5 A;  4KM3 A;  1XGO A;  2Q94 A;  2B3K A;  1WLR A;  1W7V A;  2P99 A;  2BWS A;  4U75 A;  2Q95 A;  1WY2 A;  3Q6D A;  1WL9 A;  1QXY A;  4IEC A;  1YW8 A;  2BWU A;  4ZWU A;  4FO8 A;  2GG2 A;  2BWW A;  4R60 A;  4RZY A;  5CLS A;  2GU6 A;  2MAT A;  1WBQ A;  1QXZ A;  2GG9 A;  1R58 A;  4OOK A;  4U6W A;  2IW2 A;  3FMQ A;  4PNC A;  4MAT A;  4JUQ A;  1XGM A;  3CTZ A;  4IDY A;  2BN7 A;  4RGZ 1;  4PV4 A;  5CDL A;  2ADU A;  1XGS A;  5FCH A;  2V3Y A;  3IG4 A;  3ROR A;  2BH3 A;  4S2R P;  2EA4 A;  5CE6 A;  2BWY A;  4A6V A;  1R5G A;  2Q96 A;  5CIK A;  1O0X A;  3TB5 A;  2Q8K A;  3BIP A;  3CB6 A;  3RVA A;  4U6C A;  1CHM A;  1R5H A;  2GTX A;  2DFI A;  2NQ7 A;  2ZSG A;  2GU4 A;  2HOW A;  3BIT A;  2GG7 A;  2V3X A;  1B59 A;  1M35 A;  2P9A A;  5JI6 A;  2BHD A;  1A16 A;  3D27 A;  2Q93 A;  2BB7 A;  4FLL A;  2GG8 A;  5JFR A;  4U76 A; 
#chains in the Genus database with same CATH topology
 2BHA A;  1BN5 A;  1BOA A;  3PKB A;  1C24 A;  1KQ0 A;  2V3Z A;  1WN1 A;  4FLI A;  4B28 A;  2EVO A;  2OAZ A;  3BIQ A;  4IPA A;  4ZWP A;  1Y1N A;  2EA2 A;  4IKR A;  4ZWO A;  5CDV A;  4FO7 A;  2G6P A;  2GGB A;  5JHU A;  2EVM A;  1MAT A;  4S00 A;  2GG3 A;  4FKC A;  4U6Z A;  5E5B A;  2EVC A;  2GZ5 A;  2BWX A;  4IF7 A;  3MAT A;  2GG0 A;  2B3L A;  2BHB A;  1JAW A;  1YW7 A;  2GGC A;  2GA2 A;  4FUK A;  5D6F A;  2B3H A;  3MX6 A;  3PKA A;  3L24 A;  4RZZ A;  4U6J A;  2OKN A;  4IKS A;  1YW9 A;  3PKD A;  1KQ9 A;  1B6A A;  1YVM A;  4U69 A;  5D6E A;  4U6E A;  2GU7 A;  2BWV A;  3PKC A;  1QXW A;  1C22 A;  2GG5 A;  3IU9 A;  1C23 A;  1PV9 A;  3IU7 A;  2BHC A;  4U1B A;  4Z7M A;  1C21 A;  3CB5 A;  4ZNG A;  4IKT A;  4S2T P;  5FCF A;  2P98 A;  3FM3 A;  3FMR A;  4QR8 A;  3S6B A;  1WKM A;  2Q92 A;  3PKE A;  5CNX A;  5CDE A;  1KP0 A;  4FLK A;  4U70 A;  4EGE A;  1XNZ A;  1C27 A;  2NQ6 A;  3MR1 A;  4FLJ A;  4S01 A;  3IU8 A;  4U71 A;  1WL6 A;  1N51 A;  1W2M A;  3L7G A;  4IU6 A;  4HXX A;  1XGN A;  4IKU A;  4A6W A;  3TAV A;  2BWT A;  1QZY A;  2V6C A;  4U73 A;  1YJ3 A;  2GU5 A;  4KM3 A;  1XGO A;  2Q94 A;  2B3K A;  1WLR A;  1W7V A;  2P99 A;  2BWS A;  4U75 A;  2Q95 A;  1WY2 A;  3Q6D A;  1WL9 A;  1QXY A;  4IEC A;  1YW8 A;  2BWU A;  4ZWU A;  4FO8 A;  2GG2 A;  2BWW A;  4R60 A;  4RZY A;  5CLS A;  2GU6 A;  2MAT A;  1WBQ A;  1QXZ A;  2GG9 A;  1R58 A;  4OOK A;  4U6W A;  2IW2 A;  3FMQ A;  4PNC A;  4MAT A;  4JUQ A;  1XGM A;  3CTZ A;  4IDY A;  2BN7 A;  4RGZ 1;  4PV4 A;  5CDL A;  2ADU A;  1XGS A;  5FCH A;  2V3Y A;  3IG4 A;  3ROR A;  2BH3 A;  4S2R P;  2EA4 A;  5CE6 A;  2BWY A;  4A6V A;  1R5G A;  2Q96 A;  5CIK A;  1O0X A;  3TB5 A;  2Q8K A;  3BIP A;  3CB6 A;  3RVA A;  4U6C A;  1CHM A;  1R5H A;  2GTX A;  2DFI A;  2NQ7 A;  2ZSG A;  2GU4 A;  2HOW A;  3BIT A;  2GG7 A;  2V3X A;  1B59 A;  1M35 A;  2P9A A;  5JI6 A;  2BHD A;  1A16 A;  3D27 A;  2Q93 A;  2BB7 A;  4FLL A;  2GG8 A;  5JFR A;  4U76 A; 
#chains in the Genus database with same CATH homology
 2BHA A;  1BN5 A;  1BOA A;  3PKB A;  1C24 A;  1KQ0 A;  2V3Z A;  1WN1 A;  4FLI A;  4B28 A;  2EVO A;  2OAZ A;  3BIQ A;  4IPA A;  4ZWP A;  1Y1N A;  2EA2 A;  4IKR A;  4ZWO A;  5CDV A;  4FO7 A;  2G6P A;  2GGB A;  5JHU A;  2EVM A;  1MAT A;  4S00 A;  2GG3 A;  4FKC A;  4U6Z A;  5E5B A;  2EVC A;  2GZ5 A;  2BWX A;  4IF7 A;  3MAT A;  2GG0 A;  2B3L A;  2BHB A;  1JAW A;  1YW7 A;  2GGC A;  2GA2 A;  4FUK A;  5D6F A;  2B3H A;  3MX6 A;  3PKA A;  3L24 A;  4RZZ A;  4U6J A;  2OKN A;  4IKS A;  1YW9 A;  3PKD A;  1KQ9 A;  1B6A A;  1YVM A;  4U69 A;  5D6E A;  4U6E A;  2GU7 A;  2BWV A;  3PKC A;  1QXW A;  1C22 A;  2GG5 A;  3IU9 A;  1C23 A;  1PV9 A;  3IU7 A;  2BHC A;  4U1B A;  4Z7M A;  1C21 A;  3CB5 A;  4ZNG A;  4IKT A;  4S2T P;  5FCF A;  2P98 A;  3FM3 A;  3FMR A;  4QR8 A;  3S6B A;  1WKM A;  2Q92 A;  3PKE A;  5CNX A;  5CDE A;  1KP0 A;  4FLK A;  4U70 A;  4EGE A;  1XNZ A;  1C27 A;  2NQ6 A;  3MR1 A;  4FLJ A;  4S01 A;  3IU8 A;  4U71 A;  1WL6 A;  1N51 A;  1W2M A;  3L7G A;  4IU6 A;  4HXX A;  1XGN A;  4IKU A;  4A6W A;  3TAV A;  2BWT A;  1QZY A;  2V6C A;  4U73 A;  1YJ3 A;  2GU5 A;  4KM3 A;  1XGO A;  2Q94 A;  2B3K A;  1WLR A;  1W7V A;  2P99 A;  2BWS A;  4U75 A;  2Q95 A;  1WY2 A;  3Q6D A;  1WL9 A;  1QXY A;  4IEC A;  1YW8 A;  2BWU A;  4ZWU A;  4FO8 A;  2GG2 A;  2BWW A;  4R60 A;  4RZY A;  5CLS A;  2GU6 A;  2MAT A;  1WBQ A;  1QXZ A;  2GG9 A;  1R58 A;  4OOK A;  4U6W A;  2IW2 A;  3FMQ A;  4PNC A;  4MAT A;  4JUQ A;  1XGM A;  3CTZ A;  4IDY A;  2BN7 A;  4RGZ 1;  4PV4 A;  5CDL A;  2ADU A;  1XGS A;  5FCH A;  2V3Y A;  3IG4 A;  3ROR A;  2BH3 A;  4S2R P;  2EA4 A;  5CE6 A;  2BWY A;  4A6V A;  1R5G A;  2Q96 A;  5CIK A;  1O0X A;  3TB5 A;  2Q8K A;  3BIP A;  3CB6 A;  3RVA A;  4U6C A;  1CHM A;  1R5H A;  2GTX A;  2DFI A;  2NQ7 A;  2ZSG A;  2GU4 A;  2HOW A;  3BIT A;  2GG7 A;  2V3X A;  1B59 A;  1M35 A;  2P9A A;  5JI6 A;  2BHD A;  1A16 A;  3D27 A;  2Q93 A;  2BB7 A;  4FLL A;  2GG8 A;  5JFR A;  4U76 A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...