2P99A

E. coli methionine aminopeptidase monometalated with inhibitor ye6
Total Genus 85
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
85
sequence length
261
structure length
261
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISH
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
molecule keywords Methionine aminopeptidase
publication title Inhibition of Monometalated Methionine Aminopeptidase: Inhibitor Discovery and Crystallographic Analysis.
pubmed doi rcsb
source organism Escherichia coli
total genus 85
structure length 261
sequence length 261
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2007-03-24

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 2p99A00
2OAZA 1XGMA 2B3LA 5FCHA 2BWVA 4IKTA 4FLLA 1WKMA 4FLIA 2GGCA 1KQ0A 4ZWPA 2OKNA 4IF7A 3TAVA 1JAWA 1YW7A 4S2TP 4ZWUA 4U70A 1BOAA 4U71A 3CB5A 3CB6A 3L24A 3IU8A 2G6PA 4R60A 2V3YA 1A16A 4U6CA 2B3HA 2GZ5A 2Q95A 3PKCA 3CTZA 1R58A 2BHCA 1QXZA 2BWSA 1YJ3A 5CDLA 5CNXA 2GTXA 2GG7A 3Q6DA 1BN5A 1YW9A 3PKDA 2EVCA 1MATA 1WY2A 5CE6A 1C21A 3IG4A 4IPAA 1C24A 1WLRA 4ZWOA 4U76A 3RVAA 4FLKA 2V3XA 1B59A 2NQ7A 2GG0A 1XNZA 1PV9A 1QXWA 2B3KA 2BWUA 2ADUA 1KQ9A 2HOWA 4A6WA 4RZYA 5CLSA 3RORA 2GGBA 5CIKA 1R5GA 1M35A 4IKSA 4FUKA 3TB5A 4MATA 2P98A 4JUQA 2GG3A 5JHUA 1O0XA 4RZZA 3IU7A 4EGEA 2GU7A 4Z7MA 2BWTA 1XGNA 2GU6A 1WN1A 2GU4A 2BWYA 2BH3A 5CDVA 2BWXA 3D27A 2Q96A 4KM3A 2EVOA 1C27A 5JI6A 4U73A 1QXYA 3BIQA 4IU6A 1CHMA 2GG5A 3FMQA 2IW2A 4IECA 4U6WA 4U6ZA 5JFRA 3BIPA 4FO7A 2Q94A 3IU9A 4B28A 1WL9A 4OOKA 1B6AA 2MATA 2GG2A 2GG9A 1XGOA 4PV4A 1YVMA 4FKCA 2V3ZA 4FLJA 5FCFA 2BHAA 2DFIA 2V6CA 1Y1NA 4PNCA 4RGZ1 2BB7A 2GU5A 2Q93A 4U75A 1C22A 2BHBA 1R5HA 2P99A 2BN7A 3MR1A 2Q8KA 2EA2A 4QR8A 4S00A 4IKUA 4S2RP 5CDEA 5E5BA 3PKAA 3FMRA 3PKBA 1N51A 2BWWA 4U6JA 1XGSA 3BITA 4S01A 1W7VA 2Q92A 3MX6A 5D6FA 2GG8A 2EVMA 4HXXA 1W2MA 1YW8A 1C23A 1WL6A 3FM3A 4U69A 2GA2A 1QZYA 5D6EA 3S6BA 4FO8A 1KP0A 2BHDA 2EA4A 4IKRA 3MATA 4ZNGA 2NQ6A 2ZSGA 4U6EA 4IDYA 1WBQA 4A6VA 4U1BA 3PKEA 3L7GA 2P9AA
chains in the Genus database with same CATH superfamily
2OAZA 1XGMA 2B3LA 5FCHA 2BWVA 4IKTA 4FLLA 1WKMA 4FLIA 2GGCA 1KQ0A 4ZWPA 2OKNA 4IF7A 3TAVA 1JAWA 1YW7A 4S2TP 4ZWUA 4U70A 1BOAA 4U71A 3CB5A 3CB6A 3L24A 3IU8A 2G6PA 4R60A 2V3YA 1A16A 4U6CA 2B3HA 2GZ5A 2Q95A 3PKCA 3CTZA 1R58A 2BHCA 1QXZA 2BWSA 1YJ3A 5CDLA 5CNXA 2GTXA 2GG7A 3Q6DA 1BN5A 1YW9A 3PKDA 2EVCA 1MATA 1WY2A 5CE6A 1C21A 3IG4A 4IPAA 1C24A 1WLRA 4ZWOA 4U76A 3RVAA 4FLKA 2V3XA 1B59A 2NQ7A 2GG0A 1XNZA 1PV9A 1QXWA 2B3KA 2BWUA 2ADUA 1KQ9A 2HOWA 4A6WA 4RZYA 5CLSA 3RORA 2GGBA 5CIKA 1R5GA 1M35A 4IKSA 4FUKA 3TB5A 4MATA 2P98A 4JUQA 2GG3A 5JHUA 1O0XA 4RZZA 3IU7A 4EGEA 2GU7A 4Z7MA 2BWTA 1XGNA 2GU6A 1WN1A 2GU4A 2BWYA 2BH3A 5CDVA 2BWXA 3D27A 2Q96A 4KM3A 2EVOA 1C27A 5JI6A 4U73A 1QXYA 3BIQA 4IU6A 1CHMA 2GG5A 3FMQA 2IW2A 4IECA 4U6WA 4U6ZA 5JFRA 3BIPA 4FO7A 2Q94A 3IU9A 4B28A 1WL9A 4OOKA 1B6AA 2MATA 2GG2A 2GG9A 1XGOA 4PV4A 1YVMA 4FKCA 2V3ZA 4FLJA 5FCFA 2BHAA 2DFIA 2V6CA 1Y1NA 4PNCA 4RGZ1 2BB7A 2GU5A 2Q93A 4U75A 1C22A 2BHBA 1R5HA 2P99A 2BN7A 3MR1A 2Q8KA 2EA2A 4QR8A 4S00A 4IKUA 4S2RP 5CDEA 5E5BA 3PKAA 3FMRA 3PKBA 1N51A 2BWWA 4U6JA 1XGSA 3BITA 4S01A 1W7VA 2Q92A 3MX6A 5D6FA 2GG8A 2EVMA 4HXXA 1W2MA 1YW8A 1C23A 1WL6A 3FM3A 4U69A 2GA2A 1QZYA 5D6EA 3S6BA 4FO8A 1KP0A 2BHDA 2EA4A 4IKRA 3MATA 4ZNGA 2NQ6A 2ZSGA 4U6EA 4IDYA 1WBQA 4A6VA 4U1BA 3PKEA 3L7GA 2P9AA
chains in the Genus database with same CATH topology
2OAZA 1XGMA 2B3LA 5FCHA 2BWVA 4IKTA 4FLLA 1WKMA 4FLIA 2GGCA 1KQ0A 4ZWPA 2OKNA 4IF7A 3TAVA 1JAWA 1YW7A 4S2TP 4ZWUA 4U70A 1BOAA 4U71A 3CB5A 3CB6A 3L24A 3IU8A 2G6PA 4R60A 2V3YA 1A16A 4U6CA 2B3HA 2GZ5A 2Q95A 3PKCA 3CTZA 1R58A 2BHCA 1QXZA 2BWSA 1YJ3A 5CDLA 5CNXA 2GTXA 2GG7A 3Q6DA 1BN5A 1YW9A 3PKDA 2EVCA 1MATA 1WY2A 5CE6A 1C21A 3IG4A 4IPAA 1C24A 1WLRA 4ZWOA 4U76A 3RVAA 4FLKA 2V3XA 1B59A 2NQ7A 2GG0A 1XNZA 1PV9A 1QXWA 2B3KA 2BWUA 2ADUA 1KQ9A 2HOWA 4A6WA 4RZYA 5CLSA 3RORA 2GGBA 5CIKA 1R5GA 1M35A 4IKSA 4FUKA 3TB5A 4MATA 2P98A 4JUQA 2GG3A 5JHUA 1O0XA 4RZZA 3IU7A 4EGEA 2GU7A 4Z7MA 2BWTA 1XGNA 2GU6A 1WN1A 2GU4A 2BWYA 2BH3A 5CDVA 2BWXA 3D27A 2Q96A 4KM3A 2EVOA 1C27A 5JI6A 4U73A 1QXYA 3BIQA 4IU6A 1CHMA 2GG5A 3FMQA 2IW2A 4IECA 4U6WA 4U6ZA 5JFRA 3BIPA 4FO7A 2Q94A 3IU9A 4B28A 1WL9A 4OOKA 1B6AA 2MATA 2GG2A 2GG9A 1XGOA 4PV4A 1YVMA 4FKCA 2V3ZA 4FLJA 5FCFA 2BHAA 2DFIA 2V6CA 1Y1NA 4PNCA 4RGZ1 2BB7A 2GU5A 2Q93A 4U75A 1C22A 2BHBA 1R5HA 2P99A 2BN7A 3MR1A 2Q8KA 2EA2A 4QR8A 4S00A 4IKUA 4S2RP 5CDEA 5E5BA 3PKAA 3FMRA 3PKBA 1N51A 2BWWA 4U6JA 1XGSA 3BITA 4S01A 1W7VA 2Q92A 3MX6A 5D6FA 2GG8A 2EVMA 4HXXA 1W2MA 1YW8A 1C23A 1WL6A 3FM3A 4U69A 2GA2A 1QZYA 5D6EA 3S6BA 4FO8A 1KP0A 2BHDA 2EA4A 4IKRA 3MATA 4ZNGA 2NQ6A 2ZSGA 4U6EA 4IDYA 1WBQA 4A6VA 4U1BA 3PKEA 3L7GA 2P9AA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2OAZ A;  1XGM A;  2B3L A;  5FCH A;  2BWV A;  4IKT A;  4FLL A;  1WKM A;  4FLI A;  2GGC A;  1KQ0 A;  4ZWP A;  2OKN A;  4IF7 A;  3TAV A;  1JAW A;  1YW7 A;  4S2T P;  4ZWU A;  4U70 A;  1BOA A;  4U71 A;  3CB5 A;  3CB6 A;  3L24 A;  3IU8 A;  2G6P A;  4R60 A;  2V3Y A;  1A16 A;  4U6C A;  2B3H A;  2GZ5 A;  2Q95 A;  3PKC A;  3CTZ A;  1R58 A;  2BHC A;  1QXZ A;  2BWS A;  1YJ3 A;  5CDL A;  5CNX A;  2GTX A;  2GG7 A;  3Q6D A;  1BN5 A;  1YW9 A;  3PKD A;  2EVC A;  1MAT A;  1WY2 A;  5CE6 A;  1C21 A;  3IG4 A;  4IPA A;  1C24 A;  1WLR A;  4ZWO A;  4U76 A;  3RVA A;  4FLK A;  2V3X A;  1B59 A;  2NQ7 A;  2GG0 A;  1XNZ A;  1PV9 A;  1QXW A;  2B3K A;  2BWU A;  2ADU A;  1KQ9 A;  2HOW A;  4A6W A;  4RZY A;  5CLS A;  3ROR A;  2GGB A;  5CIK A;  1R5G A;  1M35 A;  4IKS A;  4FUK A;  3TB5 A;  4MAT A;  2P98 A;  4JUQ A;  2GG3 A;  5JHU A;  1O0X A;  4RZZ A;  3IU7 A;  4EGE A;  2GU7 A;  4Z7M A;  2BWT A;  1XGN A;  2GU6 A;  1WN1 A;  2GU4 A;  2BWY A;  2BH3 A;  5CDV A;  2BWX A;  3D27 A;  2Q96 A;  4KM3 A;  2EVO A;  1C27 A;  5JI6 A;  4U73 A;  1QXY A;  3BIQ A;  4IU6 A;  1CHM A;  2GG5 A;  3FMQ A;  2IW2 A;  4IEC A;  4U6W A;  4U6Z A;  5JFR A;  3BIP A;  4FO7 A;  2Q94 A;  3IU9 A;  4B28 A;  1WL9 A;  4OOK A;  1B6A A;  2MAT A;  2GG2 A;  2GG9 A;  1XGO A;  4PV4 A;  1YVM A;  4FKC A;  2V3Z A;  4FLJ A;  5FCF A;  2BHA A;  2DFI A;  2V6C A;  1Y1N A;  4PNC A;  4RGZ 1;  2BB7 A;  2GU5 A;  2Q93 A;  4U75 A;  1C22 A;  2BHB A;  1R5H A;  2P99 A;  2BN7 A;  3MR1 A;  2Q8K A;  2EA2 A;  4QR8 A;  4S00 A;  4IKU A;  4S2R P;  5CDE A;  5E5B A;  3PKA A;  3FMR A;  3PKB A;  1N51 A;  2BWW A;  4U6J A;  1XGS A;  3BIT A;  4S01 A;  1W7V A;  2Q92 A;  3MX6 A;  5D6F A;  2GG8 A;  2EVM A;  4HXX A;  1W2M A;  1YW8 A;  1C23 A;  1WL6 A;  3FM3 A;  4U69 A;  2GA2 A;  1QZY A;  5D6E A;  3S6B A;  4FO8 A;  1KP0 A;  2BHD A;  2EA4 A;  4IKR A;  3MAT A;  4ZNG A;  2NQ6 A;  2ZSG A;  4U6E A;  4IDY A;  1WBQ A;  4A6V A;  4U1B A;  3PKE A;  3L7G A;  2P9A A; 
#chains in the Genus database with same CATH topology
 2OAZ A;  1XGM A;  2B3L A;  5FCH A;  2BWV A;  4IKT A;  4FLL A;  1WKM A;  4FLI A;  2GGC A;  1KQ0 A;  4ZWP A;  2OKN A;  4IF7 A;  3TAV A;  1JAW A;  1YW7 A;  4S2T P;  4ZWU A;  4U70 A;  1BOA A;  4U71 A;  3CB5 A;  3CB6 A;  3L24 A;  3IU8 A;  2G6P A;  4R60 A;  2V3Y A;  1A16 A;  4U6C A;  2B3H A;  2GZ5 A;  2Q95 A;  3PKC A;  3CTZ A;  1R58 A;  2BHC A;  1QXZ A;  2BWS A;  1YJ3 A;  5CDL A;  5CNX A;  2GTX A;  2GG7 A;  3Q6D A;  1BN5 A;  1YW9 A;  3PKD A;  2EVC A;  1MAT A;  1WY2 A;  5CE6 A;  1C21 A;  3IG4 A;  4IPA A;  1C24 A;  1WLR A;  4ZWO A;  4U76 A;  3RVA A;  4FLK A;  2V3X A;  1B59 A;  2NQ7 A;  2GG0 A;  1XNZ A;  1PV9 A;  1QXW A;  2B3K A;  2BWU A;  2ADU A;  1KQ9 A;  2HOW A;  4A6W A;  4RZY A;  5CLS A;  3ROR A;  2GGB A;  5CIK A;  1R5G A;  1M35 A;  4IKS A;  4FUK A;  3TB5 A;  4MAT A;  2P98 A;  4JUQ A;  2GG3 A;  5JHU A;  1O0X A;  4RZZ A;  3IU7 A;  4EGE A;  2GU7 A;  4Z7M A;  2BWT A;  1XGN A;  2GU6 A;  1WN1 A;  2GU4 A;  2BWY A;  2BH3 A;  5CDV A;  2BWX A;  3D27 A;  2Q96 A;  4KM3 A;  2EVO A;  1C27 A;  5JI6 A;  4U73 A;  1QXY A;  3BIQ A;  4IU6 A;  1CHM A;  2GG5 A;  3FMQ A;  2IW2 A;  4IEC A;  4U6W A;  4U6Z A;  5JFR A;  3BIP A;  4FO7 A;  2Q94 A;  3IU9 A;  4B28 A;  1WL9 A;  4OOK A;  1B6A A;  2MAT A;  2GG2 A;  2GG9 A;  1XGO A;  4PV4 A;  1YVM A;  4FKC A;  2V3Z A;  4FLJ A;  5FCF A;  2BHA A;  2DFI A;  2V6C A;  1Y1N A;  4PNC A;  4RGZ 1;  2BB7 A;  2GU5 A;  2Q93 A;  4U75 A;  1C22 A;  2BHB A;  1R5H A;  2P99 A;  2BN7 A;  3MR1 A;  2Q8K A;  2EA2 A;  4QR8 A;  4S00 A;  4IKU A;  4S2R P;  5CDE A;  5E5B A;  3PKA A;  3FMR A;  3PKB A;  1N51 A;  2BWW A;  4U6J A;  1XGS A;  3BIT A;  4S01 A;  1W7V A;  2Q92 A;  3MX6 A;  5D6F A;  2GG8 A;  2EVM A;  4HXX A;  1W2M A;  1YW8 A;  1C23 A;  1WL6 A;  3FM3 A;  4U69 A;  2GA2 A;  1QZY A;  5D6E A;  3S6B A;  4FO8 A;  1KP0 A;  2BHD A;  2EA4 A;  4IKR A;  3MAT A;  4ZNG A;  2NQ6 A;  2ZSG A;  4U6E A;  4IDY A;  1WBQ A;  4A6V A;  4U1B A;  3PKE A;  3L7G A;  2P9A A; 
#chains in the Genus database with same CATH homology
 2OAZ A;  1XGM A;  2B3L A;  5FCH A;  2BWV A;  4IKT A;  4FLL A;  1WKM A;  4FLI A;  2GGC A;  1KQ0 A;  4ZWP A;  2OKN A;  4IF7 A;  3TAV A;  1JAW A;  1YW7 A;  4S2T P;  4ZWU A;  4U70 A;  1BOA A;  4U71 A;  3CB5 A;  3CB6 A;  3L24 A;  3IU8 A;  2G6P A;  4R60 A;  2V3Y A;  1A16 A;  4U6C A;  2B3H A;  2GZ5 A;  2Q95 A;  3PKC A;  3CTZ A;  1R58 A;  2BHC A;  1QXZ A;  2BWS A;  1YJ3 A;  5CDL A;  5CNX A;  2GTX A;  2GG7 A;  3Q6D A;  1BN5 A;  1YW9 A;  3PKD A;  2EVC A;  1MAT A;  1WY2 A;  5CE6 A;  1C21 A;  3IG4 A;  4IPA A;  1C24 A;  1WLR A;  4ZWO A;  4U76 A;  3RVA A;  4FLK A;  2V3X A;  1B59 A;  2NQ7 A;  2GG0 A;  1XNZ A;  1PV9 A;  1QXW A;  2B3K A;  2BWU A;  2ADU A;  1KQ9 A;  2HOW A;  4A6W A;  4RZY A;  5CLS A;  3ROR A;  2GGB A;  5CIK A;  1R5G A;  1M35 A;  4IKS A;  4FUK A;  3TB5 A;  4MAT A;  2P98 A;  4JUQ A;  2GG3 A;  5JHU A;  1O0X A;  4RZZ A;  3IU7 A;  4EGE A;  2GU7 A;  4Z7M A;  2BWT A;  1XGN A;  2GU6 A;  1WN1 A;  2GU4 A;  2BWY A;  2BH3 A;  5CDV A;  2BWX A;  3D27 A;  2Q96 A;  4KM3 A;  2EVO A;  1C27 A;  5JI6 A;  4U73 A;  1QXY A;  3BIQ A;  4IU6 A;  1CHM A;  2GG5 A;  3FMQ A;  2IW2 A;  4IEC A;  4U6W A;  4U6Z A;  5JFR A;  3BIP A;  4FO7 A;  2Q94 A;  3IU9 A;  4B28 A;  1WL9 A;  4OOK A;  1B6A A;  2MAT A;  2GG2 A;  2GG9 A;  1XGO A;  4PV4 A;  1YVM A;  4FKC A;  2V3Z A;  4FLJ A;  5FCF A;  2BHA A;  2DFI A;  2V6C A;  1Y1N A;  4PNC A;  4RGZ 1;  2BB7 A;  2GU5 A;  2Q93 A;  4U75 A;  1C22 A;  2BHB A;  1R5H A;  2P99 A;  2BN7 A;  3MR1 A;  2Q8K A;  2EA2 A;  4QR8 A;  4S00 A;  4IKU A;  4S2R P;  5CDE A;  5E5B A;  3PKA A;  3FMR A;  3PKB A;  1N51 A;  2BWW A;  4U6J A;  1XGS A;  3BIT A;  4S01 A;  1W7V A;  2Q92 A;  3MX6 A;  5D6F A;  2GG8 A;  2EVM A;  4HXX A;  1W2M A;  1YW8 A;  1C23 A;  1WL6 A;  3FM3 A;  4U69 A;  2GA2 A;  1QZY A;  5D6E A;  3S6B A;  4FO8 A;  1KP0 A;  2BHD A;  2EA4 A;  4IKR A;  3MAT A;  4ZNG A;  2NQ6 A;  2ZSG A;  4U6E A;  4IDY A;  1WBQ A;  4A6V A;  4U1B A;  3PKE A;  3L7G A;  2P9A A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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