3PKBA

M. tuberculosis metap with bengamide analog y16, in mn form
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
284
structure length
284
Chain Sequence
PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Methionine aminopeptidase
total genus 87
structure length 284
sequence length 284
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3pkbA01
1WLRA 2MATA 1C21A 1R58A 2Q92A 3PKBA 3RVAA 3CTZA 3PKCA 1XGSA 2EVCA 3IU9A 2GU4A 4QR8A 4IKRA 2Q96A 2V3ZA 2GU6A 1B6AA 2BB7A 3MX6A 3IG4A 1QXYA 4U1BA 4ZWUA 2ADUA 4IU6A 2NQ7A 2Q8KA 1XNZA 1CHMA 1KP0A 1XGMA 2GA2A 3BITA 2BHDA 1M35A 4KM3A 1R5GA 3FMQA 4PNCA 4U70A 1WN1A 2Q94A 4EGEA 2OAZA 2NQ6A 3L7GA 3PKAA 2GG9A 3CB5A 4IPAA 4ZWPA 4RZZA 1N51A 3BIPA 1QXZA 1YW7A 3IU8A 4R60A 2B3HA 2EA2A 4ZNGA 4U71A 2V6CA 3S6BA 1WL9A 1YW9A 3TAVA 3TB5A 4FLIA 1O0XA 1A16A 2OKNA 1Y1NA 3MR1A 4FKCA 2GG2A 3Q6DA 4FO7A 1BN5A 2EVMA 2IW2A 1WKMA 4U69A 2BWXA 5JHUA 3IU7A 4FO8A 4HXXA 4PV4A 4RGZ1 4U6ZA 4IKSA 5CLSA 2GGBA 5E5BA 5FCHA 3FMRA 2V3XA 2GU5A 4FLLA 4S01A 1BOAA 2BWSA 2BHBA 2GU7A 5FCFA 2BWTA 4S2RP 2GG0A 5CDVA 4ZWOA 3PKEA 5CE6A 2GG5A 4IDYA 2GTXA 1B59A 1C23A 5CDEA 3BIQA 1W7VA 1PV9A 3RORA 4IECA 4JUQA 1YJ3A 1C22A 3CB6A 4U6EA 4U76A 2B3LA 2Q93A 3MATA 4A6WA 2BH3A 4IF7A 2GZ5A 2ZSGA 1XGNA 1W2MA 5JFRA 2BWYA 1KQ9A 4FUKA 4MATA 4FLKA 1R5HA 2GG3A 1JAWA 1KQ0A 2B3KA 2GGCA 5CNXA 5D6FA 3PKDA 1WL6A 4U6CA 1QZYA 1C24A 2EA4A 3D27A 4FLJA 5CDLA 2DFIA 4U6JA 2BWWA 5D6EA 3FM3A 1YW8A 3L24A 2BHAA 2G6PA 1C27A 4Z7MA 4S00A 4U6WA 4A6VA 2P9AA 2P99A 4B28A 1YVMA 4U73A 1QXWA 2BWVA 4OOKA 1XGOA 2P98A 1WBQA 1WY2A 2EVOA 2HOWA 4IKTA 1MATA 5JI6A 2V3YA 2BWUA 4IKUA 2BHCA 4U75A 5CIKA 2BN7A 2GG7A 2Q95A 4S2TP 2GG8A 4RZYA
chains in the Genus database with same CATH superfamily
1WLRA 2MATA 1C21A 1R58A 2Q92A 3PKBA 3RVAA 3CTZA 3PKCA 1XGSA 2EVCA 3IU9A 2GU4A 4QR8A 4IKRA 2Q96A 2V3ZA 2GU6A 1B6AA 2BB7A 3MX6A 3IG4A 1QXYA 4U1BA 4ZWUA 2ADUA 4IU6A 2NQ7A 2Q8KA 1XNZA 1CHMA 1KP0A 1XGMA 2GA2A 3BITA 2BHDA 1M35A 4KM3A 1R5GA 3FMQA 4PNCA 4U70A 1WN1A 2Q94A 4EGEA 2OAZA 2NQ6A 3L7GA 3PKAA 2GG9A 3CB5A 4IPAA 4ZWPA 4RZZA 1N51A 3BIPA 1QXZA 1YW7A 3IU8A 4R60A 2B3HA 2EA2A 4ZNGA 4U71A 2V6CA 3S6BA 1WL9A 1YW9A 3TAVA 3TB5A 4FLIA 1O0XA 1A16A 2OKNA 1Y1NA 3MR1A 4FKCA 2GG2A 3Q6DA 4FO7A 1BN5A 2EVMA 2IW2A 1WKMA 4U69A 2BWXA 5JHUA 3IU7A 4FO8A 4HXXA 4PV4A 4RGZ1 4U6ZA 4IKSA 5CLSA 2GGBA 5E5BA 5FCHA 3FMRA 2V3XA 2GU5A 4FLLA 4S01A 1BOAA 2BWSA 2BHBA 2GU7A 5FCFA 2BWTA 4S2RP 2GG0A 5CDVA 4ZWOA 3PKEA 5CE6A 2GG5A 4IDYA 2GTXA 1B59A 1C23A 5CDEA 3BIQA 1W7VA 1PV9A 3RORA 4IECA 4JUQA 1YJ3A 1C22A 3CB6A 4U6EA 4U76A 2B3LA 2Q93A 3MATA 4A6WA 2BH3A 4IF7A 2GZ5A 2ZSGA 1XGNA 1W2MA 5JFRA 2BWYA 1KQ9A 4FUKA 4MATA 4FLKA 1R5HA 2GG3A 1JAWA 1KQ0A 2B3KA 2GGCA 5CNXA 5D6FA 3PKDA 1WL6A 4U6CA 1QZYA 1C24A 2EA4A 3D27A 4FLJA 5CDLA 2DFIA 4U6JA 2BWWA 5D6EA 3FM3A 1YW8A 3L24A 2BHAA 2G6PA 1C27A 4Z7MA 4S00A 4U6WA 4A6VA 2P9AA 2P99A 4B28A 1YVMA 4U73A 1QXWA 2BWVA 4OOKA 1XGOA 2P98A 1WBQA 1WY2A 2EVOA 2HOWA 4IKTA 1MATA 5JI6A 2V3YA 2BWUA 4IKUA 2BHCA 4U75A 5CIKA 2BN7A 2GG7A 2Q95A 4S2TP 2GG8A 4RZYA
chains in the Genus database with same CATH topology
1WLRA 2MATA 1C21A 1R58A 2Q92A 3PKBA 3RVAA 3CTZA 3PKCA 1XGSA 2EVCA 3IU9A 2GU4A 4QR8A 4IKRA 2Q96A 2V3ZA 2GU6A 1B6AA 2BB7A 3MX6A 3IG4A 1QXYA 4U1BA 4ZWUA 2ADUA 4IU6A 2NQ7A 2Q8KA 1XNZA 1CHMA 1KP0A 1XGMA 2GA2A 3BITA 2BHDA 1M35A 4KM3A 1R5GA 3FMQA 4PNCA 4U70A 1WN1A 2Q94A 4EGEA 2OAZA 2NQ6A 3L7GA 3PKAA 2GG9A 3CB5A 4IPAA 4ZWPA 4RZZA 1N51A 3BIPA 1QXZA 1YW7A 3IU8A 4R60A 2B3HA 2EA2A 4ZNGA 4U71A 2V6CA 3S6BA 1WL9A 1YW9A 3TAVA 3TB5A 4FLIA 1O0XA 1A16A 2OKNA 1Y1NA 3MR1A 4FKCA 2GG2A 3Q6DA 4FO7A 1BN5A 2EVMA 2IW2A 1WKMA 4U69A 2BWXA 5JHUA 3IU7A 4FO8A 4HXXA 4PV4A 4RGZ1 4U6ZA 4IKSA 5CLSA 2GGBA 5E5BA 5FCHA 3FMRA 2V3XA 2GU5A 4FLLA 4S01A 1BOAA 2BWSA 2BHBA 2GU7A 5FCFA 2BWTA 4S2RP 2GG0A 5CDVA 4ZWOA 3PKEA 5CE6A 2GG5A 4IDYA 2GTXA 1B59A 1C23A 5CDEA 3BIQA 1W7VA 1PV9A 3RORA 4IECA 4JUQA 1YJ3A 1C22A 3CB6A 4U6EA 4U76A 2B3LA 2Q93A 3MATA 4A6WA 2BH3A 4IF7A 2GZ5A 2ZSGA 1XGNA 1W2MA 5JFRA 2BWYA 1KQ9A 4FUKA 4MATA 4FLKA 1R5HA 2GG3A 1JAWA 1KQ0A 2B3KA 2GGCA 5CNXA 5D6FA 3PKDA 1WL6A 4U6CA 1QZYA 1C24A 2EA4A 3D27A 4FLJA 5CDLA 2DFIA 4U6JA 2BWWA 5D6EA 3FM3A 1YW8A 3L24A 2BHAA 2G6PA 1C27A 4Z7MA 4S00A 4U6WA 4A6VA 2P9AA 2P99A 4B28A 1YVMA 4U73A 1QXWA 2BWVA 4OOKA 1XGOA 2P98A 1WBQA 1WY2A 2EVOA 2HOWA 4IKTA 1MATA 5JI6A 2V3YA 2BWUA 4IKUA 2BHCA 4U75A 5CIKA 2BN7A 2GG7A 2Q95A 4S2TP 2GG8A 4RZYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1WLR A;  2MAT A;  1C21 A;  1R58 A;  2Q92 A;  3PKB A;  3RVA A;  3CTZ A;  3PKC A;  1XGS A;  2EVC A;  3IU9 A;  2GU4 A;  4QR8 A;  4IKR A;  2Q96 A;  2V3Z A;  2GU6 A;  1B6A A;  2BB7 A;  3MX6 A;  3IG4 A;  1QXY A;  4U1B A;  4ZWU A;  2ADU A;  4IU6 A;  2NQ7 A;  2Q8K A;  1XNZ A;  1CHM A;  1KP0 A;  1XGM A;  2GA2 A;  3BIT A;  2BHD A;  1M35 A;  4KM3 A;  1R5G A;  3FMQ A;  4PNC A;  4U70 A;  1WN1 A;  2Q94 A;  4EGE A;  2OAZ A;  2NQ6 A;  3L7G A;  3PKA A;  2GG9 A;  3CB5 A;  4IPA A;  4ZWP A;  4RZZ A;  1N51 A;  3BIP A;  1QXZ A;  1YW7 A;  3IU8 A;  4R60 A;  2B3H A;  2EA2 A;  4ZNG A;  4U71 A;  2V6C A;  3S6B A;  1WL9 A;  1YW9 A;  3TAV A;  3TB5 A;  4FLI A;  1O0X A;  1A16 A;  2OKN A;  1Y1N A;  3MR1 A;  4FKC A;  2GG2 A;  3Q6D A;  4FO7 A;  1BN5 A;  2EVM A;  2IW2 A;  1WKM A;  4U69 A;  2BWX A;  5JHU A;  3IU7 A;  4FO8 A;  4HXX A;  4PV4 A;  4RGZ 1;  4U6Z A;  4IKS A;  5CLS A;  2GGB A;  5E5B A;  5FCH A;  3FMR A;  2V3X A;  2GU5 A;  4FLL A;  4S01 A;  1BOA A;  2BWS A;  2BHB A;  2GU7 A;  5FCF A;  2BWT A;  4S2R P;  2GG0 A;  5CDV A;  4ZWO A;  3PKE A;  5CE6 A;  2GG5 A;  4IDY A;  2GTX A;  1B59 A;  1C23 A;  5CDE A;  3BIQ A;  1W7V A;  1PV9 A;  3ROR A;  4IEC A;  4JUQ A;  1YJ3 A;  1C22 A;  3CB6 A;  4U6E A;  4U76 A;  2B3L A;  2Q93 A;  3MAT A;  4A6W A;  2BH3 A;  4IF7 A;  2GZ5 A;  2ZSG A;  1XGN A;  1W2M A;  5JFR A;  2BWY A;  1KQ9 A;  4FUK A;  4MAT A;  4FLK A;  1R5H A;  2GG3 A;  1JAW A;  1KQ0 A;  2B3K A;  2GGC A;  5CNX A;  5D6F A;  3PKD A;  1WL6 A;  4U6C A;  1QZY A;  1C24 A;  2EA4 A;  3D27 A;  4FLJ A;  5CDL A;  2DFI A;  4U6J A;  2BWW A;  5D6E A;  3FM3 A;  1YW8 A;  3L24 A;  2BHA A;  2G6P A;  1C27 A;  4Z7M A;  4S00 A;  4U6W A;  4A6V A;  2P9A A;  2P99 A;  4B28 A;  1YVM A;  4U73 A;  1QXW A;  2BWV A;  4OOK A;  1XGO A;  2P98 A;  1WBQ A;  1WY2 A;  2EVO A;  2HOW A;  4IKT A;  1MAT A;  5JI6 A;  2V3Y A;  2BWU A;  4IKU A;  2BHC A;  4U75 A;  5CIK A;  2BN7 A;  2GG7 A;  2Q95 A;  4S2T P;  2GG8 A;  4RZY A; 
#chains in the Genus database with same CATH topology
 1WLR A;  2MAT A;  1C21 A;  1R58 A;  2Q92 A;  3PKB A;  3RVA A;  3CTZ A;  3PKC A;  1XGS A;  2EVC A;  3IU9 A;  2GU4 A;  4QR8 A;  4IKR A;  2Q96 A;  2V3Z A;  2GU6 A;  1B6A A;  2BB7 A;  3MX6 A;  3IG4 A;  1QXY A;  4U1B A;  4ZWU A;  2ADU A;  4IU6 A;  2NQ7 A;  2Q8K A;  1XNZ A;  1CHM A;  1KP0 A;  1XGM A;  2GA2 A;  3BIT A;  2BHD A;  1M35 A;  4KM3 A;  1R5G A;  3FMQ A;  4PNC A;  4U70 A;  1WN1 A;  2Q94 A;  4EGE A;  2OAZ A;  2NQ6 A;  3L7G A;  3PKA A;  2GG9 A;  3CB5 A;  4IPA A;  4ZWP A;  4RZZ A;  1N51 A;  3BIP A;  1QXZ A;  1YW7 A;  3IU8 A;  4R60 A;  2B3H A;  2EA2 A;  4ZNG A;  4U71 A;  2V6C A;  3S6B A;  1WL9 A;  1YW9 A;  3TAV A;  3TB5 A;  4FLI A;  1O0X A;  1A16 A;  2OKN A;  1Y1N A;  3MR1 A;  4FKC A;  2GG2 A;  3Q6D A;  4FO7 A;  1BN5 A;  2EVM A;  2IW2 A;  1WKM A;  4U69 A;  2BWX A;  5JHU A;  3IU7 A;  4FO8 A;  4HXX A;  4PV4 A;  4RGZ 1;  4U6Z A;  4IKS A;  5CLS A;  2GGB A;  5E5B A;  5FCH A;  3FMR A;  2V3X A;  2GU5 A;  4FLL A;  4S01 A;  1BOA A;  2BWS A;  2BHB A;  2GU7 A;  5FCF A;  2BWT A;  4S2R P;  2GG0 A;  5CDV A;  4ZWO A;  3PKE A;  5CE6 A;  2GG5 A;  4IDY A;  2GTX A;  1B59 A;  1C23 A;  5CDE A;  3BIQ A;  1W7V A;  1PV9 A;  3ROR A;  4IEC A;  4JUQ A;  1YJ3 A;  1C22 A;  3CB6 A;  4U6E A;  4U76 A;  2B3L A;  2Q93 A;  3MAT A;  4A6W A;  2BH3 A;  4IF7 A;  2GZ5 A;  2ZSG A;  1XGN A;  1W2M A;  5JFR A;  2BWY A;  1KQ9 A;  4FUK A;  4MAT A;  4FLK A;  1R5H A;  2GG3 A;  1JAW A;  1KQ0 A;  2B3K A;  2GGC A;  5CNX A;  5D6F A;  3PKD A;  1WL6 A;  4U6C A;  1QZY A;  1C24 A;  2EA4 A;  3D27 A;  4FLJ A;  5CDL A;  2DFI A;  4U6J A;  2BWW A;  5D6E A;  3FM3 A;  1YW8 A;  3L24 A;  2BHA A;  2G6P A;  1C27 A;  4Z7M A;  4S00 A;  4U6W A;  4A6V A;  2P9A A;  2P99 A;  4B28 A;  1YVM A;  4U73 A;  1QXW A;  2BWV A;  4OOK A;  1XGO A;  2P98 A;  1WBQ A;  1WY2 A;  2EVO A;  2HOW A;  4IKT A;  1MAT A;  5JI6 A;  2V3Y A;  2BWU A;  4IKU A;  2BHC A;  4U75 A;  5CIK A;  2BN7 A;  2GG7 A;  2Q95 A;  4S2T P;  2GG8 A;  4RZY A; 
#chains in the Genus database with same CATH homology
 1WLR A;  2MAT A;  1C21 A;  1R58 A;  2Q92 A;  3PKB A;  3RVA A;  3CTZ A;  3PKC A;  1XGS A;  2EVC A;  3IU9 A;  2GU4 A;  4QR8 A;  4IKR A;  2Q96 A;  2V3Z A;  2GU6 A;  1B6A A;  2BB7 A;  3MX6 A;  3IG4 A;  1QXY A;  4U1B A;  4ZWU A;  2ADU A;  4IU6 A;  2NQ7 A;  2Q8K A;  1XNZ A;  1CHM A;  1KP0 A;  1XGM A;  2GA2 A;  3BIT A;  2BHD A;  1M35 A;  4KM3 A;  1R5G A;  3FMQ A;  4PNC A;  4U70 A;  1WN1 A;  2Q94 A;  4EGE A;  2OAZ A;  2NQ6 A;  3L7G A;  3PKA A;  2GG9 A;  3CB5 A;  4IPA A;  4ZWP A;  4RZZ A;  1N51 A;  3BIP A;  1QXZ A;  1YW7 A;  3IU8 A;  4R60 A;  2B3H A;  2EA2 A;  4ZNG A;  4U71 A;  2V6C A;  3S6B A;  1WL9 A;  1YW9 A;  3TAV A;  3TB5 A;  4FLI A;  1O0X A;  1A16 A;  2OKN A;  1Y1N A;  3MR1 A;  4FKC A;  2GG2 A;  3Q6D A;  4FO7 A;  1BN5 A;  2EVM A;  2IW2 A;  1WKM A;  4U69 A;  2BWX A;  5JHU A;  3IU7 A;  4FO8 A;  4HXX A;  4PV4 A;  4RGZ 1;  4U6Z A;  4IKS A;  5CLS A;  2GGB A;  5E5B A;  5FCH A;  3FMR A;  2V3X A;  2GU5 A;  4FLL A;  4S01 A;  1BOA A;  2BWS A;  2BHB A;  2GU7 A;  5FCF A;  2BWT A;  4S2R P;  2GG0 A;  5CDV A;  4ZWO A;  3PKE A;  5CE6 A;  2GG5 A;  4IDY A;  2GTX A;  1B59 A;  1C23 A;  5CDE A;  3BIQ A;  1W7V A;  1PV9 A;  3ROR A;  4IEC A;  4JUQ A;  1YJ3 A;  1C22 A;  3CB6 A;  4U6E A;  4U76 A;  2B3L A;  2Q93 A;  3MAT A;  4A6W A;  2BH3 A;  4IF7 A;  2GZ5 A;  2ZSG A;  1XGN A;  1W2M A;  5JFR A;  2BWY A;  1KQ9 A;  4FUK A;  4MAT A;  4FLK A;  1R5H A;  2GG3 A;  1JAW A;  1KQ0 A;  2B3K A;  2GGC A;  5CNX A;  5D6F A;  3PKD A;  1WL6 A;  4U6C A;  1QZY A;  1C24 A;  2EA4 A;  3D27 A;  4FLJ A;  5CDL A;  2DFI A;  4U6J A;  2BWW A;  5D6E A;  3FM3 A;  1YW8 A;  3L24 A;  2BHA A;  2G6P A;  1C27 A;  4Z7M A;  4S00 A;  4U6W A;  4A6V A;  2P9A A;  2P99 A;  4B28 A;  1YVM A;  4U73 A;  1QXW A;  2BWV A;  4OOK A;  1XGO A;  2P98 A;  1WBQ A;  1WY2 A;  2EVO A;  2HOW A;  4IKT A;  1MAT A;  5JI6 A;  2V3Y A;  2BWU A;  4IKU A;  2BHC A;  4U75 A;  5CIK A;  2BN7 A;  2GG7 A;  2Q95 A;  4S2T P;  2GG8 A;  4RZY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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