3PKBA

M. tuberculosis metap with bengamide analog y16, in mn form
Total Genus 87
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
87
sequence length
284
structure length
284
Chain Sequence
PSRTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTCL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Mycobacterium tuberculosis
publication title Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 87
structure length 284
sequence length 284
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3pkbA01
4ZNGA 5CLSA 2Q8KA 3PKEA 4U76A 2OKNA 2BHAA 3TB5A 2GU7A 4IECA 1BN5A 4U71A 4U6JA 2EVMA 1BOAA 4U1BA 2BB7A 3MR1A 4EGEA 3PKAA 5JHUA 4FO7A 2GZ5A 4IKSA 1YVMA 4U75A 2GG7A 4U6ZA 2BWXA 2BWVA 1KQ0A 2V3XA 2BH3A 4IKTA 2EA4A 5CDLA 4FUKA 1KQ9A 1WBQA 2BWUA 1QXWA 2IW2A 2G6PA 2V6CA 4ZWUA 2BWSA 2GTXA 4U6CA 3TAVA 4A6WA 3FMQA 4R60A 4S2RP 3IU8A 5CNXA 1YW8A 4KM3A 2ZSGA 1QXYA 3FMRA 3PKBA 4Z7MA 1R5HA 3BITA 1PV9A 4U6EA 1W7VA 4HXXA 1XGSA 3L24A 2B3KA 2OAZA 2P99A 3D27A 1C22A 2EA2A 3L7GA 4FKCA 1R5GA 3PKDA 1XGMA 2GGCA 2BWYA 4PNCA 4S01A 5JFRA 1XGNA 1CHMA 2BWTA 2Q96A 2Q95A 4FO8A 2ADUA 3IU7A 1WLRA 2P9AA 2Q94A 4IKUA 1KP0A 4U70A 4ZWPA 3RVAA 1C24A 2Q92A 2P98A 5E5BA 2EVOA 2GG3A 2GG0A 3PKCA 5JI6A 5FCFA 1C27A 4IPAA 4A6VA 3IG4A 2BHBA 2NQ7A 4FLJA 4IKRA 2V3ZA 3BIQA 2MATA 1B59A 3CB5A 3CTZA 1QZYA 1N51A 4IF7A 5CDVA 4U6WA 1WL9A 4FLIA 3MATA 4RZZA 1A16A 4OOKA 4QR8A 4FLLA 2GGBA 1WY2A 1R58A 2GU5A 3S6BA 5FCHA 4RGZ1 3FM3A 4RZYA 1W2MA 2GG9A 2GG5A 3BIPA 2NQ6A 1WN1A 5CE6A 1C21A 2Q93A 4ZWOA 2GG8A 4U73A 1WKMA 1YW7A 1QXZA 4S2TP 4IDYA 2BWWA 5D6EA 2DFIA 3IU9A 4B28A 2GU4A 4FLKA 4PV4A 3MX6A 3RORA 2HOWA 2GG2A 1M35A 1YJ3A 2V3YA 1XGOA 5D6FA 2GU6A 1MATA 2EVCA 5CDEA 5CIKA 2GA2A 1YW9A 1C23A 2BN7A 2BHDA 4MATA 1O0XA 1Y1NA 1B6AA 3Q6DA 4JUQA 4S00A 2B3HA 4IU6A 1XNZA 3CB6A 1JAWA 4U69A 1WL6A 2B3LA 2BHCA
chains in the Genus database with same CATH superfamily
4ZNGA 5CLSA 2Q8KA 3PKEA 4U76A 2OKNA 2BHAA 3TB5A 2GU7A 4IECA 1BN5A 4U71A 4U6JA 2EVMA 1BOAA 4U1BA 2BB7A 3MR1A 4EGEA 3PKAA 5JHUA 4FO7A 2GZ5A 4IKSA 1YVMA 4U75A 2GG7A 4U6ZA 2BWXA 2BWVA 1KQ0A 2V3XA 2BH3A 4IKTA 2EA4A 5CDLA 4FUKA 1KQ9A 1WBQA 2BWUA 1QXWA 2IW2A 2G6PA 2V6CA 4ZWUA 2BWSA 2GTXA 4U6CA 3TAVA 4A6WA 3FMQA 4R60A 4S2RP 3IU8A 5CNXA 1YW8A 4KM3A 2ZSGA 1QXYA 3FMRA 3PKBA 4Z7MA 1R5HA 3BITA 1PV9A 4U6EA 1W7VA 4HXXA 1XGSA 3L24A 2B3KA 2OAZA 2P99A 3D27A 1C22A 2EA2A 3L7GA 4FKCA 1R5GA 3PKDA 1XGMA 2GGCA 2BWYA 4PNCA 4S01A 5JFRA 1XGNA 1CHMA 2BWTA 2Q96A 2Q95A 4FO8A 2ADUA 3IU7A 1WLRA 2P9AA 2Q94A 4IKUA 1KP0A 4U70A 4ZWPA 3RVAA 1C24A 2Q92A 2P98A 5E5BA 2EVOA 2GG3A 2GG0A 3PKCA 5JI6A 5FCFA 1C27A 4IPAA 4A6VA 3IG4A 2BHBA 2NQ7A 4FLJA 4IKRA 2V3ZA 3BIQA 2MATA 1B59A 3CB5A 3CTZA 1QZYA 1N51A 4IF7A 5CDVA 4U6WA 1WL9A 4FLIA 3MATA 4RZZA 1A16A 4OOKA 4QR8A 4FLLA 2GGBA 1WY2A 1R58A 2GU5A 3S6BA 5FCHA 4RGZ1 3FM3A 4RZYA 1W2MA 2GG9A 2GG5A 3BIPA 2NQ6A 1WN1A 5CE6A 1C21A 2Q93A 4ZWOA 2GG8A 4U73A 1WKMA 1YW7A 1QXZA 4S2TP 4IDYA 2BWWA 5D6EA 2DFIA 3IU9A 4B28A 2GU4A 4FLKA 4PV4A 3MX6A 3RORA 2HOWA 2GG2A 1M35A 1YJ3A 2V3YA 1XGOA 5D6FA 2GU6A 1MATA 2EVCA 5CDEA 5CIKA 2GA2A 1YW9A 1C23A 2BN7A 2BHDA 4MATA 1O0XA 1Y1NA 1B6AA 3Q6DA 4JUQA 4S00A 2B3HA 4IU6A 1XNZA 3CB6A 1JAWA 4U69A 1WL6A 2B3LA 2BHCA
chains in the Genus database with same CATH topology
4ZNGA 5CLSA 2Q8KA 3PKEA 4U76A 2OKNA 2BHAA 3TB5A 2GU7A 4IECA 1BN5A 4U71A 4U6JA 2EVMA 1BOAA 4U1BA 2BB7A 3MR1A 4EGEA 3PKAA 5JHUA 4FO7A 2GZ5A 4IKSA 1YVMA 4U75A 2GG7A 4U6ZA 2BWXA 2BWVA 1KQ0A 2V3XA 2BH3A 4IKTA 2EA4A 5CDLA 4FUKA 1KQ9A 1WBQA 2BWUA 1QXWA 2IW2A 2G6PA 2V6CA 4ZWUA 2BWSA 2GTXA 4U6CA 3TAVA 4A6WA 3FMQA 4R60A 4S2RP 3IU8A 5CNXA 1YW8A 4KM3A 2ZSGA 1QXYA 3FMRA 3PKBA 4Z7MA 1R5HA 3BITA 1PV9A 4U6EA 1W7VA 4HXXA 1XGSA 3L24A 2B3KA 2OAZA 2P99A 3D27A 1C22A 2EA2A 3L7GA 4FKCA 1R5GA 3PKDA 1XGMA 2GGCA 2BWYA 4PNCA 4S01A 5JFRA 1XGNA 1CHMA 2BWTA 2Q96A 2Q95A 4FO8A 2ADUA 3IU7A 1WLRA 2P9AA 2Q94A 4IKUA 1KP0A 4U70A 4ZWPA 3RVAA 1C24A 2Q92A 2P98A 5E5BA 2EVOA 2GG3A 2GG0A 3PKCA 5JI6A 5FCFA 1C27A 4IPAA 4A6VA 3IG4A 2BHBA 2NQ7A 4FLJA 4IKRA 2V3ZA 3BIQA 2MATA 1B59A 3CB5A 3CTZA 1QZYA 1N51A 4IF7A 5CDVA 4U6WA 1WL9A 4FLIA 3MATA 4RZZA 1A16A 4OOKA 4QR8A 4FLLA 2GGBA 1WY2A 1R58A 2GU5A 3S6BA 5FCHA 4RGZ1 3FM3A 4RZYA 1W2MA 2GG9A 2GG5A 3BIPA 2NQ6A 1WN1A 5CE6A 1C21A 2Q93A 4ZWOA 2GG8A 4U73A 1WKMA 1YW7A 1QXZA 4S2TP 4IDYA 2BWWA 5D6EA 2DFIA 3IU9A 4B28A 2GU4A 4FLKA 4PV4A 3MX6A 3RORA 2HOWA 2GG2A 1M35A 1YJ3A 2V3YA 1XGOA 5D6FA 2GU6A 1MATA 2EVCA 5CDEA 5CIKA 2GA2A 1YW9A 1C23A 2BN7A 2BHDA 4MATA 1O0XA 1Y1NA 1B6AA 3Q6DA 4JUQA 4S00A 2B3HA 4IU6A 1XNZA 3CB6A 1JAWA 4U69A 1WL6A 2B3LA 2BHCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZNG A;  5CLS A;  2Q8K A;  3PKE A;  4U76 A;  2OKN A;  2BHA A;  3TB5 A;  2GU7 A;  4IEC A;  1BN5 A;  4U71 A;  4U6J A;  2EVM A;  1BOA A;  4U1B A;  2BB7 A;  3MR1 A;  4EGE A;  3PKA A;  5JHU A;  4FO7 A;  2GZ5 A;  4IKS A;  1YVM A;  4U75 A;  2GG7 A;  4U6Z A;  2BWX A;  2BWV A;  1KQ0 A;  2V3X A;  2BH3 A;  4IKT A;  2EA4 A;  5CDL A;  4FUK A;  1KQ9 A;  1WBQ A;  2BWU A;  1QXW A;  2IW2 A;  2G6P A;  2V6C A;  4ZWU A;  2BWS A;  2GTX A;  4U6C A;  3TAV A;  4A6W A;  3FMQ A;  4R60 A;  4S2R P;  3IU8 A;  5CNX A;  1YW8 A;  4KM3 A;  2ZSG A;  1QXY A;  3FMR A;  3PKB A;  4Z7M A;  1R5H A;  3BIT A;  1PV9 A;  4U6E A;  1W7V A;  4HXX A;  1XGS A;  3L24 A;  2B3K A;  2OAZ A;  2P99 A;  3D27 A;  1C22 A;  2EA2 A;  3L7G A;  4FKC A;  1R5G A;  3PKD A;  1XGM A;  2GGC A;  2BWY A;  4PNC A;  4S01 A;  5JFR A;  1XGN A;  1CHM A;  2BWT A;  2Q96 A;  2Q95 A;  4FO8 A;  2ADU A;  3IU7 A;  1WLR A;  2P9A A;  2Q94 A;  4IKU A;  1KP0 A;  4U70 A;  4ZWP A;  3RVA A;  1C24 A;  2Q92 A;  2P98 A;  5E5B A;  2EVO A;  2GG3 A;  2GG0 A;  3PKC A;  5JI6 A;  5FCF A;  1C27 A;  4IPA A;  4A6V A;  3IG4 A;  2BHB A;  2NQ7 A;  4FLJ A;  4IKR A;  2V3Z A;  3BIQ A;  2MAT A;  1B59 A;  3CB5 A;  3CTZ A;  1QZY A;  1N51 A;  4IF7 A;  5CDV A;  4U6W A;  1WL9 A;  4FLI A;  3MAT A;  4RZZ A;  1A16 A;  4OOK A;  4QR8 A;  4FLL A;  2GGB A;  1WY2 A;  1R58 A;  2GU5 A;  3S6B A;  5FCH A;  4RGZ 1;  3FM3 A;  4RZY A;  1W2M A;  2GG9 A;  2GG5 A;  3BIP A;  2NQ6 A;  1WN1 A;  5CE6 A;  1C21 A;  2Q93 A;  4ZWO A;  2GG8 A;  4U73 A;  1WKM A;  1YW7 A;  1QXZ A;  4S2T P;  4IDY A;  2BWW A;  5D6E A;  2DFI A;  3IU9 A;  4B28 A;  2GU4 A;  4FLK A;  4PV4 A;  3MX6 A;  3ROR A;  2HOW A;  2GG2 A;  1M35 A;  1YJ3 A;  2V3Y A;  1XGO A;  5D6F A;  2GU6 A;  1MAT A;  2EVC A;  5CDE A;  5CIK A;  2GA2 A;  1YW9 A;  1C23 A;  2BN7 A;  2BHD A;  4MAT A;  1O0X A;  1Y1N A;  1B6A A;  3Q6D A;  4JUQ A;  4S00 A;  2B3H A;  4IU6 A;  1XNZ A;  3CB6 A;  1JAW A;  4U69 A;  1WL6 A;  2B3L A;  2BHC A; 
#chains in the Genus database with same CATH topology
 4ZNG A;  5CLS A;  2Q8K A;  3PKE A;  4U76 A;  2OKN A;  2BHA A;  3TB5 A;  2GU7 A;  4IEC A;  1BN5 A;  4U71 A;  4U6J A;  2EVM A;  1BOA A;  4U1B A;  2BB7 A;  3MR1 A;  4EGE A;  3PKA A;  5JHU A;  4FO7 A;  2GZ5 A;  4IKS A;  1YVM A;  4U75 A;  2GG7 A;  4U6Z A;  2BWX A;  2BWV A;  1KQ0 A;  2V3X A;  2BH3 A;  4IKT A;  2EA4 A;  5CDL A;  4FUK A;  1KQ9 A;  1WBQ A;  2BWU A;  1QXW A;  2IW2 A;  2G6P A;  2V6C A;  4ZWU A;  2BWS A;  2GTX A;  4U6C A;  3TAV A;  4A6W A;  3FMQ A;  4R60 A;  4S2R P;  3IU8 A;  5CNX A;  1YW8 A;  4KM3 A;  2ZSG A;  1QXY A;  3FMR A;  3PKB A;  4Z7M A;  1R5H A;  3BIT A;  1PV9 A;  4U6E A;  1W7V A;  4HXX A;  1XGS A;  3L24 A;  2B3K A;  2OAZ A;  2P99 A;  3D27 A;  1C22 A;  2EA2 A;  3L7G A;  4FKC A;  1R5G A;  3PKD A;  1XGM A;  2GGC A;  2BWY A;  4PNC A;  4S01 A;  5JFR A;  1XGN A;  1CHM A;  2BWT A;  2Q96 A;  2Q95 A;  4FO8 A;  2ADU A;  3IU7 A;  1WLR A;  2P9A A;  2Q94 A;  4IKU A;  1KP0 A;  4U70 A;  4ZWP A;  3RVA A;  1C24 A;  2Q92 A;  2P98 A;  5E5B A;  2EVO A;  2GG3 A;  2GG0 A;  3PKC A;  5JI6 A;  5FCF A;  1C27 A;  4IPA A;  4A6V A;  3IG4 A;  2BHB A;  2NQ7 A;  4FLJ A;  4IKR A;  2V3Z A;  3BIQ A;  2MAT A;  1B59 A;  3CB5 A;  3CTZ A;  1QZY A;  1N51 A;  4IF7 A;  5CDV A;  4U6W A;  1WL9 A;  4FLI A;  3MAT A;  4RZZ A;  1A16 A;  4OOK A;  4QR8 A;  4FLL A;  2GGB A;  1WY2 A;  1R58 A;  2GU5 A;  3S6B A;  5FCH A;  4RGZ 1;  3FM3 A;  4RZY A;  1W2M A;  2GG9 A;  2GG5 A;  3BIP A;  2NQ6 A;  1WN1 A;  5CE6 A;  1C21 A;  2Q93 A;  4ZWO A;  2GG8 A;  4U73 A;  1WKM A;  1YW7 A;  1QXZ A;  4S2T P;  4IDY A;  2BWW A;  5D6E A;  2DFI A;  3IU9 A;  4B28 A;  2GU4 A;  4FLK A;  4PV4 A;  3MX6 A;  3ROR A;  2HOW A;  2GG2 A;  1M35 A;  1YJ3 A;  2V3Y A;  1XGO A;  5D6F A;  2GU6 A;  1MAT A;  2EVC A;  5CDE A;  5CIK A;  2GA2 A;  1YW9 A;  1C23 A;  2BN7 A;  2BHD A;  4MAT A;  1O0X A;  1Y1N A;  1B6A A;  3Q6D A;  4JUQ A;  4S00 A;  2B3H A;  4IU6 A;  1XNZ A;  3CB6 A;  1JAW A;  4U69 A;  1WL6 A;  2B3L A;  2BHC A; 
#chains in the Genus database with same CATH homology
 4ZNG A;  5CLS A;  2Q8K A;  3PKE A;  4U76 A;  2OKN A;  2BHA A;  3TB5 A;  2GU7 A;  4IEC A;  1BN5 A;  4U71 A;  4U6J A;  2EVM A;  1BOA A;  4U1B A;  2BB7 A;  3MR1 A;  4EGE A;  3PKA A;  5JHU A;  4FO7 A;  2GZ5 A;  4IKS A;  1YVM A;  4U75 A;  2GG7 A;  4U6Z A;  2BWX A;  2BWV A;  1KQ0 A;  2V3X A;  2BH3 A;  4IKT A;  2EA4 A;  5CDL A;  4FUK A;  1KQ9 A;  1WBQ A;  2BWU A;  1QXW A;  2IW2 A;  2G6P A;  2V6C A;  4ZWU A;  2BWS A;  2GTX A;  4U6C A;  3TAV A;  4A6W A;  3FMQ A;  4R60 A;  4S2R P;  3IU8 A;  5CNX A;  1YW8 A;  4KM3 A;  2ZSG A;  1QXY A;  3FMR A;  3PKB A;  4Z7M A;  1R5H A;  3BIT A;  1PV9 A;  4U6E A;  1W7V A;  4HXX A;  1XGS A;  3L24 A;  2B3K A;  2OAZ A;  2P99 A;  3D27 A;  1C22 A;  2EA2 A;  3L7G A;  4FKC A;  1R5G A;  3PKD A;  1XGM A;  2GGC A;  2BWY A;  4PNC A;  4S01 A;  5JFR A;  1XGN A;  1CHM A;  2BWT A;  2Q96 A;  2Q95 A;  4FO8 A;  2ADU A;  3IU7 A;  1WLR A;  2P9A A;  2Q94 A;  4IKU A;  1KP0 A;  4U70 A;  4ZWP A;  3RVA A;  1C24 A;  2Q92 A;  2P98 A;  5E5B A;  2EVO A;  2GG3 A;  2GG0 A;  3PKC A;  5JI6 A;  5FCF A;  1C27 A;  4IPA A;  4A6V A;  3IG4 A;  2BHB A;  2NQ7 A;  4FLJ A;  4IKR A;  2V3Z A;  3BIQ A;  2MAT A;  1B59 A;  3CB5 A;  3CTZ A;  1QZY A;  1N51 A;  4IF7 A;  5CDV A;  4U6W A;  1WL9 A;  4FLI A;  3MAT A;  4RZZ A;  1A16 A;  4OOK A;  4QR8 A;  4FLL A;  2GGB A;  1WY2 A;  1R58 A;  2GU5 A;  3S6B A;  5FCH A;  4RGZ 1;  3FM3 A;  4RZY A;  1W2M A;  2GG9 A;  2GG5 A;  3BIP A;  2NQ6 A;  1WN1 A;  5CE6 A;  1C21 A;  2Q93 A;  4ZWO A;  2GG8 A;  4U73 A;  1WKM A;  1YW7 A;  1QXZ A;  4S2T P;  4IDY A;  2BWW A;  5D6E A;  2DFI A;  3IU9 A;  4B28 A;  2GU4 A;  4FLK A;  4PV4 A;  3MX6 A;  3ROR A;  2HOW A;  2GG2 A;  1M35 A;  1YJ3 A;  2V3Y A;  1XGO A;  5D6F A;  2GU6 A;  1MAT A;  2EVC A;  5CDE A;  5CIK A;  2GA2 A;  1YW9 A;  1C23 A;  2BN7 A;  2BHD A;  4MAT A;  1O0X A;  1Y1N A;  1B6A A;  3Q6D A;  4JUQ A;  4S00 A;  2B3H A;  4IU6 A;  1XNZ A;  3CB6 A;  1JAW A;  4U69 A;  1WL6 A;  2B3L A;  2BHC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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