3PKCA

M. tuberculosis metap with bengamide analog y08, in mn form
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
281
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidases by Bengamide Derivatives.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Mycobacterium tuberculosis
molecule keywords Methionine aminopeptidase
total genus 86
structure length 281
sequence length 281
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2010-11-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 3pkcA01
4FLKA 3CB5A 1XGNA 2GGCA 4HXXA 3TAVA 3L7GA 2V3XA 3IU7A 2GA2A 4B28A 3D27A 1QXZA 1XNZA 2V3ZA 2V6CA 4FLJA 2GG7A 4ZWOA 1Y1NA 4U6CA 4IF7A 4IKTA 4IKRA 1YW7A 3BIPA 4S2TP 3CTZA 2DFIA 2GG9A 2BWTA 4IPAA 4RZYA 4U70A 4ZNGA 3MATA 1R5GA 2G6PA 1W2MA 3MR1A 2BH3A 1W7VA 4OOKA 4ZWUA 1M35A 1C23A 1C24A 2MATA 4IECA 1C22A 1XGMA 4FKCA 5CLSA 4KM3A 4JUQA 4R60A 4IU6A 1WBQA 2GZ5A 5CDVA 2ZSGA 4IKUA 2BWXA 1YW9A 4FLLA 2B3KA 2BWYA 2GTXA 2GU7A 3PKBA 2EA2A 2NQ7A 4U6JA 1WL6A 1O0XA 1XGSA 2BHAA 2BWVA 4PV4A 5D6FA 1WN1A 5D6EA 2EA4A 1C27A 3PKCA 2B3HA 2P99A 3BITA 1YJ3A 2Q95A 5JFRA 1XGOA 2GGBA 5CE6A 1BOAA 2IW2A 1R5HA 3BIQA 2BHCA 2GG8A 1C21A 4IKSA 2P9AA 4U6EA 5CNXA 4IDYA 2BWUA 3IU9A 2EVMA 2BHBA 2V3YA 3FM3A 4FLIA 1YW8A 3IU8A 2GG0A 1WLRA 1A16A 1QXWA 1QZYA 2Q96A 4RGZ1 1QXYA 2EVOA 4EGEA 2GG5A 2Q93A 1KQ0A 3PKDA 3PKAA 2Q94A 5FCHA 4U71A 4S01A 2GG3A 4FO8A 4A6VA 4Z7MA 1JAWA 2P98A 4S00A 2GU6A 3CB6A 5JHUA 1MATA 4U69A 4U76A 2GG2A 4U6WA 1B6AA 2BWWA 2Q8KA 1KP0A 1WL9A 3MX6A 1KQ9A 5E5BA 4U75A 3FMRA 3PKEA 3RORA 4S2RP 3S6BA 2BWSA 1N51A 2OAZA 3FMQA 3TB5A 2EVCA 2B3LA 5JI6A 2GU5A 2NQ6A 4U73A 2Q92A 2BN7A 4PNCA 1WKMA 2BHDA 4FO7A 5FCFA 1WY2A 3IG4A 5CIKA 4U6ZA 3RVAA 2HOWA 3Q6DA 4FUKA 4ZWPA 4MATA 3L24A 4QR8A 4RZZA 1CHMA 2OKNA 1BN5A 2GU4A 1YVMA 2BB7A 1R58A 4U1BA 4A6WA 5CDLA 1PV9A 5CDEA 1B59A 2ADUA
chains in the Genus database with same CATH superfamily
4FLKA 3CB5A 1XGNA 2GGCA 4HXXA 3TAVA 3L7GA 2V3XA 3IU7A 2GA2A 4B28A 3D27A 1QXZA 1XNZA 2V3ZA 2V6CA 4FLJA 2GG7A 4ZWOA 1Y1NA 4U6CA 4IF7A 4IKTA 4IKRA 1YW7A 3BIPA 4S2TP 3CTZA 2DFIA 2GG9A 2BWTA 4IPAA 4RZYA 4U70A 4ZNGA 3MATA 1R5GA 2G6PA 1W2MA 3MR1A 2BH3A 1W7VA 4OOKA 4ZWUA 1M35A 1C23A 1C24A 2MATA 4IECA 1C22A 1XGMA 4FKCA 5CLSA 4KM3A 4JUQA 4R60A 4IU6A 1WBQA 2GZ5A 5CDVA 2ZSGA 4IKUA 2BWXA 1YW9A 4FLLA 2B3KA 2BWYA 2GTXA 2GU7A 3PKBA 2EA2A 2NQ7A 4U6JA 1WL6A 1O0XA 1XGSA 2BHAA 2BWVA 4PV4A 5D6FA 1WN1A 5D6EA 2EA4A 1C27A 3PKCA 2B3HA 2P99A 3BITA 1YJ3A 2Q95A 5JFRA 1XGOA 2GGBA 5CE6A 1BOAA 2IW2A 1R5HA 3BIQA 2BHCA 2GG8A 1C21A 4IKSA 2P9AA 4U6EA 5CNXA 4IDYA 2BWUA 3IU9A 2EVMA 2BHBA 2V3YA 3FM3A 4FLIA 1YW8A 3IU8A 2GG0A 1WLRA 1A16A 1QXWA 1QZYA 2Q96A 4RGZ1 1QXYA 2EVOA 4EGEA 2GG5A 2Q93A 1KQ0A 3PKDA 3PKAA 2Q94A 5FCHA 4U71A 4S01A 2GG3A 4FO8A 4A6VA 4Z7MA 1JAWA 2P98A 4S00A 2GU6A 3CB6A 5JHUA 1MATA 4U69A 4U76A 2GG2A 4U6WA 1B6AA 2BWWA 2Q8KA 1KP0A 1WL9A 3MX6A 1KQ9A 5E5BA 4U75A 3FMRA 3PKEA 3RORA 4S2RP 3S6BA 2BWSA 1N51A 2OAZA 3FMQA 3TB5A 2EVCA 2B3LA 5JI6A 2GU5A 2NQ6A 4U73A 2Q92A 2BN7A 4PNCA 1WKMA 2BHDA 4FO7A 5FCFA 1WY2A 3IG4A 5CIKA 4U6ZA 3RVAA 2HOWA 3Q6DA 4FUKA 4ZWPA 4MATA 3L24A 4QR8A 4RZZA 1CHMA 2OKNA 1BN5A 2GU4A 1YVMA 2BB7A 1R58A 4U1BA 4A6WA 5CDLA 1PV9A 5CDEA 1B59A 2ADUA
chains in the Genus database with same CATH topology
4FLKA 3CB5A 1XGNA 2GGCA 4HXXA 3TAVA 3L7GA 2V3XA 3IU7A 2GA2A 4B28A 3D27A 1QXZA 1XNZA 2V3ZA 2V6CA 4FLJA 2GG7A 4ZWOA 1Y1NA 4U6CA 4IF7A 4IKTA 4IKRA 1YW7A 3BIPA 4S2TP 3CTZA 2DFIA 2GG9A 2BWTA 4IPAA 4RZYA 4U70A 4ZNGA 3MATA 1R5GA 2G6PA 1W2MA 3MR1A 2BH3A 1W7VA 4OOKA 4ZWUA 1M35A 1C23A 1C24A 2MATA 4IECA 1C22A 1XGMA 4FKCA 5CLSA 4KM3A 4JUQA 4R60A 4IU6A 1WBQA 2GZ5A 5CDVA 2ZSGA 4IKUA 2BWXA 1YW9A 4FLLA 2B3KA 2BWYA 2GTXA 2GU7A 3PKBA 2EA2A 2NQ7A 4U6JA 1WL6A 1O0XA 1XGSA 2BHAA 2BWVA 4PV4A 5D6FA 1WN1A 5D6EA 2EA4A 1C27A 3PKCA 2B3HA 2P99A 3BITA 1YJ3A 2Q95A 5JFRA 1XGOA 2GGBA 5CE6A 1BOAA 2IW2A 1R5HA 3BIQA 2BHCA 2GG8A 1C21A 4IKSA 2P9AA 4U6EA 5CNXA 4IDYA 2BWUA 3IU9A 2EVMA 2BHBA 2V3YA 3FM3A 4FLIA 1YW8A 3IU8A 2GG0A 1WLRA 1A16A 1QXWA 1QZYA 2Q96A 4RGZ1 1QXYA 2EVOA 4EGEA 2GG5A 2Q93A 1KQ0A 3PKDA 3PKAA 2Q94A 5FCHA 4U71A 4S01A 2GG3A 4FO8A 4A6VA 4Z7MA 1JAWA 2P98A 4S00A 2GU6A 3CB6A 5JHUA 1MATA 4U69A 4U76A 2GG2A 4U6WA 1B6AA 2BWWA 2Q8KA 1KP0A 1WL9A 3MX6A 1KQ9A 5E5BA 4U75A 3FMRA 3PKEA 3RORA 4S2RP 3S6BA 2BWSA 1N51A 2OAZA 3FMQA 3TB5A 2EVCA 2B3LA 5JI6A 2GU5A 2NQ6A 4U73A 2Q92A 2BN7A 4PNCA 1WKMA 2BHDA 4FO7A 5FCFA 1WY2A 3IG4A 5CIKA 4U6ZA 3RVAA 2HOWA 3Q6DA 4FUKA 4ZWPA 4MATA 3L24A 4QR8A 4RZZA 1CHMA 2OKNA 1BN5A 2GU4A 1YVMA 2BB7A 1R58A 4U1BA 4A6WA 5CDLA 1PV9A 5CDEA 1B59A 2ADUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4FLK A;  3CB5 A;  1XGN A;  2GGC A;  4HXX A;  3TAV A;  3L7G A;  2V3X A;  3IU7 A;  2GA2 A;  4B28 A;  3D27 A;  1QXZ A;  1XNZ A;  2V3Z A;  2V6C A;  4FLJ A;  2GG7 A;  4ZWO A;  1Y1N A;  4U6C A;  4IF7 A;  4IKT A;  4IKR A;  1YW7 A;  3BIP A;  4S2T P;  3CTZ A;  2DFI A;  2GG9 A;  2BWT A;  4IPA A;  4RZY A;  4U70 A;  4ZNG A;  3MAT A;  1R5G A;  2G6P A;  1W2M A;  3MR1 A;  2BH3 A;  1W7V A;  4OOK A;  4ZWU A;  1M35 A;  1C23 A;  1C24 A;  2MAT A;  4IEC A;  1C22 A;  1XGM A;  4FKC A;  5CLS A;  4KM3 A;  4JUQ A;  4R60 A;  4IU6 A;  1WBQ A;  2GZ5 A;  5CDV A;  2ZSG A;  4IKU A;  2BWX A;  1YW9 A;  4FLL A;  2B3K A;  2BWY A;  2GTX A;  2GU7 A;  3PKB A;  2EA2 A;  2NQ7 A;  4U6J A;  1WL6 A;  1O0X A;  1XGS A;  2BHA A;  2BWV A;  4PV4 A;  5D6F A;  1WN1 A;  5D6E A;  2EA4 A;  1C27 A;  3PKC A;  2B3H A;  2P99 A;  3BIT A;  1YJ3 A;  2Q95 A;  5JFR A;  1XGO A;  2GGB A;  5CE6 A;  1BOA A;  2IW2 A;  1R5H A;  3BIQ A;  2BHC A;  2GG8 A;  1C21 A;  4IKS A;  2P9A A;  4U6E A;  5CNX A;  4IDY A;  2BWU A;  3IU9 A;  2EVM A;  2BHB A;  2V3Y A;  3FM3 A;  4FLI A;  1YW8 A;  3IU8 A;  2GG0 A;  1WLR A;  1A16 A;  1QXW A;  1QZY A;  2Q96 A;  4RGZ 1;  1QXY A;  2EVO A;  4EGE A;  2GG5 A;  2Q93 A;  1KQ0 A;  3PKD A;  3PKA A;  2Q94 A;  5FCH A;  4U71 A;  4S01 A;  2GG3 A;  4FO8 A;  4A6V A;  4Z7M A;  1JAW A;  2P98 A;  4S00 A;  2GU6 A;  3CB6 A;  5JHU A;  1MAT A;  4U69 A;  4U76 A;  2GG2 A;  4U6W A;  1B6A A;  2BWW A;  2Q8K A;  1KP0 A;  1WL9 A;  3MX6 A;  1KQ9 A;  5E5B A;  4U75 A;  3FMR A;  3PKE A;  3ROR A;  4S2R P;  3S6B A;  2BWS A;  1N51 A;  2OAZ A;  3FMQ A;  3TB5 A;  2EVC A;  2B3L A;  5JI6 A;  2GU5 A;  2NQ6 A;  4U73 A;  2Q92 A;  2BN7 A;  4PNC A;  1WKM A;  2BHD A;  4FO7 A;  5FCF A;  1WY2 A;  3IG4 A;  5CIK A;  4U6Z A;  3RVA A;  2HOW A;  3Q6D A;  4FUK A;  4ZWP A;  4MAT A;  3L24 A;  4QR8 A;  4RZZ A;  1CHM A;  2OKN A;  1BN5 A;  2GU4 A;  1YVM A;  2BB7 A;  1R58 A;  4U1B A;  4A6W A;  5CDL A;  1PV9 A;  5CDE A;  1B59 A;  2ADU A; 
#chains in the Genus database with same CATH topology
 4FLK A;  3CB5 A;  1XGN A;  2GGC A;  4HXX A;  3TAV A;  3L7G A;  2V3X A;  3IU7 A;  2GA2 A;  4B28 A;  3D27 A;  1QXZ A;  1XNZ A;  2V3Z A;  2V6C A;  4FLJ A;  2GG7 A;  4ZWO A;  1Y1N A;  4U6C A;  4IF7 A;  4IKT A;  4IKR A;  1YW7 A;  3BIP A;  4S2T P;  3CTZ A;  2DFI A;  2GG9 A;  2BWT A;  4IPA A;  4RZY A;  4U70 A;  4ZNG A;  3MAT A;  1R5G A;  2G6P A;  1W2M A;  3MR1 A;  2BH3 A;  1W7V A;  4OOK A;  4ZWU A;  1M35 A;  1C23 A;  1C24 A;  2MAT A;  4IEC A;  1C22 A;  1XGM A;  4FKC A;  5CLS A;  4KM3 A;  4JUQ A;  4R60 A;  4IU6 A;  1WBQ A;  2GZ5 A;  5CDV A;  2ZSG A;  4IKU A;  2BWX A;  1YW9 A;  4FLL A;  2B3K A;  2BWY A;  2GTX A;  2GU7 A;  3PKB A;  2EA2 A;  2NQ7 A;  4U6J A;  1WL6 A;  1O0X A;  1XGS A;  2BHA A;  2BWV A;  4PV4 A;  5D6F A;  1WN1 A;  5D6E A;  2EA4 A;  1C27 A;  3PKC A;  2B3H A;  2P99 A;  3BIT A;  1YJ3 A;  2Q95 A;  5JFR A;  1XGO A;  2GGB A;  5CE6 A;  1BOA A;  2IW2 A;  1R5H A;  3BIQ A;  2BHC A;  2GG8 A;  1C21 A;  4IKS A;  2P9A A;  4U6E A;  5CNX A;  4IDY A;  2BWU A;  3IU9 A;  2EVM A;  2BHB A;  2V3Y A;  3FM3 A;  4FLI A;  1YW8 A;  3IU8 A;  2GG0 A;  1WLR A;  1A16 A;  1QXW A;  1QZY A;  2Q96 A;  4RGZ 1;  1QXY A;  2EVO A;  4EGE A;  2GG5 A;  2Q93 A;  1KQ0 A;  3PKD A;  3PKA A;  2Q94 A;  5FCH A;  4U71 A;  4S01 A;  2GG3 A;  4FO8 A;  4A6V A;  4Z7M A;  1JAW A;  2P98 A;  4S00 A;  2GU6 A;  3CB6 A;  5JHU A;  1MAT A;  4U69 A;  4U76 A;  2GG2 A;  4U6W A;  1B6A A;  2BWW A;  2Q8K A;  1KP0 A;  1WL9 A;  3MX6 A;  1KQ9 A;  5E5B A;  4U75 A;  3FMR A;  3PKE A;  3ROR A;  4S2R P;  3S6B A;  2BWS A;  1N51 A;  2OAZ A;  3FMQ A;  3TB5 A;  2EVC A;  2B3L A;  5JI6 A;  2GU5 A;  2NQ6 A;  4U73 A;  2Q92 A;  2BN7 A;  4PNC A;  1WKM A;  2BHD A;  4FO7 A;  5FCF A;  1WY2 A;  3IG4 A;  5CIK A;  4U6Z A;  3RVA A;  2HOW A;  3Q6D A;  4FUK A;  4ZWP A;  4MAT A;  3L24 A;  4QR8 A;  4RZZ A;  1CHM A;  2OKN A;  1BN5 A;  2GU4 A;  1YVM A;  2BB7 A;  1R58 A;  4U1B A;  4A6W A;  5CDL A;  1PV9 A;  5CDE A;  1B59 A;  2ADU A; 
#chains in the Genus database with same CATH homology
 4FLK A;  3CB5 A;  1XGN A;  2GGC A;  4HXX A;  3TAV A;  3L7G A;  2V3X A;  3IU7 A;  2GA2 A;  4B28 A;  3D27 A;  1QXZ A;  1XNZ A;  2V3Z A;  2V6C A;  4FLJ A;  2GG7 A;  4ZWO A;  1Y1N A;  4U6C A;  4IF7 A;  4IKT A;  4IKR A;  1YW7 A;  3BIP A;  4S2T P;  3CTZ A;  2DFI A;  2GG9 A;  2BWT A;  4IPA A;  4RZY A;  4U70 A;  4ZNG A;  3MAT A;  1R5G A;  2G6P A;  1W2M A;  3MR1 A;  2BH3 A;  1W7V A;  4OOK A;  4ZWU A;  1M35 A;  1C23 A;  1C24 A;  2MAT A;  4IEC A;  1C22 A;  1XGM A;  4FKC A;  5CLS A;  4KM3 A;  4JUQ A;  4R60 A;  4IU6 A;  1WBQ A;  2GZ5 A;  5CDV A;  2ZSG A;  4IKU A;  2BWX A;  1YW9 A;  4FLL A;  2B3K A;  2BWY A;  2GTX A;  2GU7 A;  3PKB A;  2EA2 A;  2NQ7 A;  4U6J A;  1WL6 A;  1O0X A;  1XGS A;  2BHA A;  2BWV A;  4PV4 A;  5D6F A;  1WN1 A;  5D6E A;  2EA4 A;  1C27 A;  3PKC A;  2B3H A;  2P99 A;  3BIT A;  1YJ3 A;  2Q95 A;  5JFR A;  1XGO A;  2GGB A;  5CE6 A;  1BOA A;  2IW2 A;  1R5H A;  3BIQ A;  2BHC A;  2GG8 A;  1C21 A;  4IKS A;  2P9A A;  4U6E A;  5CNX A;  4IDY A;  2BWU A;  3IU9 A;  2EVM A;  2BHB A;  2V3Y A;  3FM3 A;  4FLI A;  1YW8 A;  3IU8 A;  2GG0 A;  1WLR A;  1A16 A;  1QXW A;  1QZY A;  2Q96 A;  4RGZ 1;  1QXY A;  2EVO A;  4EGE A;  2GG5 A;  2Q93 A;  1KQ0 A;  3PKD A;  3PKA A;  2Q94 A;  5FCH A;  4U71 A;  4S01 A;  2GG3 A;  4FO8 A;  4A6V A;  4Z7M A;  1JAW A;  2P98 A;  4S00 A;  2GU6 A;  3CB6 A;  5JHU A;  1MAT A;  4U69 A;  4U76 A;  2GG2 A;  4U6W A;  1B6A A;  2BWW A;  2Q8K A;  1KP0 A;  1WL9 A;  3MX6 A;  1KQ9 A;  5E5B A;  4U75 A;  3FMR A;  3PKE A;  3ROR A;  4S2R P;  3S6B A;  2BWS A;  1N51 A;  2OAZ A;  3FMQ A;  3TB5 A;  2EVC A;  2B3L A;  5JI6 A;  2GU5 A;  2NQ6 A;  4U73 A;  2Q92 A;  2BN7 A;  4PNC A;  1WKM A;  2BHD A;  4FO7 A;  5FCF A;  1WY2 A;  3IG4 A;  5CIK A;  4U6Z A;  3RVA A;  2HOW A;  3Q6D A;  4FUK A;  4ZWP A;  4MAT A;  3L24 A;  4QR8 A;  4RZZ A;  1CHM A;  2OKN A;  1BN5 A;  2GU4 A;  1YVM A;  2BB7 A;  1R58 A;  4U1B A;  4A6W A;  5CDL A;  1PV9 A;  5CDE A;  1B59 A;  2ADU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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