4FLIA

Human metap1 with bengamide analog y16, in mn form
Total Genus 100
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 100
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fliA00
2BHAA 2MATA 5CDLA 2BHDA 4MATA 3L24A 5CLSA 2GG2A 1C24A 2OAZA 4FLLA 2BHBA 5CIKA 3RORA 3D27A 2GA2A 1R5HA 4FO7A 1W7VA 2BWWA 4S2TP 2BWXA 1C23A 4FLJA 3IU8A 2OKNA 1BN5A 4OOKA 2DFIA 4EGEA 4U6JA 3CB6A 2Q93A 4IPAA 4S00A 4U1BA 5D6EA 3PKAA 1JAWA 2GU7A 4U73A 2P9AA 1QXZA 2EA2A 1XGSA 2GZ5A 4QR8A 1N51A 1KQ9A 4U6WA 3TB5A 4U71A 4IECA 4FKCA 4ZWOA 3FM3A 3PKEA 4U76A 1C21A 5JI6A 4ZWUA 2EVCA 2HOWA 2GGBA 4B28A 2Q92A 1MATA 3RVAA 4FUKA 4IDYA 2EVOA 3TAVA 1QXYA 1QZYA 3PKBA 5CE6A 4U75A 1WL6A 4A6WA 3MATA 1YVMA 2BB7A 4RZZA 2B3HA 2NQ6A 5E5BA 1PV9A 1QXWA 2BHCA 2GG5A 1KP0A 5FCHA 1WBQA 2P99A 2G6PA 4S01A 4PV4A 1C27A 1WKMA 2NQ7A 4U6ZA 5JHUA 2BWUA 4R60A 2BWTA 1KQ0A 3BIPA 1WN1A 2V6CA 1WY2A 2Q94A 2V3YA 1XNZA 2GG3A 4IKUA 3IG4A 2BWSA 2GU5A 2ADUA 2Q96A 3FMRA 1B59A 1YW8A 3PKCA 5CDVA 4U6EA 2GG8A 1B6AA 2Q95A 2V3ZA 1W2MA 4U69A 4U70A 1Y1NA 4U6CA 5CNXA 4IKRA 4IF7A 1M35A 1WLRA 2V3XA 4FLKA 2BN7A 1YW7A 2EVMA 1WL9A 2BWVA 4JUQA 3BIQA 4Z7MA 4RGZ1 3MR1A 3CB5A 3Q6DA 3PKDA 2GTXA 1R5GA 1O0XA 1C22A 5D6FA 4IKTA 4IU6A 1BOAA 3BITA 3IU9A 4HXXA 2GU6A 2GGCA 4PNCA 3L7GA 2GG7A 4ZNGA 2IW2A 1A16A 1YW9A 1CHMA 2GG9A 1R58A 4ZWPA 1XGNA 3S6BA 4FLIA 2Q8KA 4S2RP 1XGMA 2GU4A 4IKSA 3CTZA 2BH3A 1YJ3A 2GG0A 2EA4A 2P98A 5FCFA 4KM3A 5CDEA 2ZSGA 1XGOA 3FMQA 4A6VA 4FO8A 2BWYA 5JFRA 3MX6A 4RZYA 3IU7A 2B3LA 2B3KA
chains in the Genus database with same CATH superfamily
2BHAA 2MATA 5CDLA 2BHDA 4MATA 3L24A 5CLSA 2GG2A 1C24A 2OAZA 4FLLA 2BHBA 5CIKA 3RORA 3D27A 2GA2A 1R5HA 4FO7A 1W7VA 2BWWA 4S2TP 2BWXA 1C23A 4FLJA 3IU8A 2OKNA 1BN5A 4OOKA 2DFIA 4EGEA 4U6JA 3CB6A 2Q93A 4IPAA 4S00A 4U1BA 5D6EA 3PKAA 1JAWA 2GU7A 4U73A 2P9AA 1QXZA 2EA2A 1XGSA 2GZ5A 4QR8A 1N51A 1KQ9A 4U6WA 3TB5A 4U71A 4IECA 4FKCA 4ZWOA 3FM3A 3PKEA 4U76A 1C21A 5JI6A 4ZWUA 2EVCA 2HOWA 2GGBA 4B28A 2Q92A 1MATA 3RVAA 4FUKA 4IDYA 2EVOA 3TAVA 1QXYA 1QZYA 3PKBA 5CE6A 4U75A 1WL6A 4A6WA 3MATA 1YVMA 2BB7A 4RZZA 2B3HA 2NQ6A 5E5BA 1PV9A 1QXWA 2BHCA 2GG5A 1KP0A 5FCHA 1WBQA 2P99A 2G6PA 4S01A 4PV4A 1C27A 1WKMA 2NQ7A 4U6ZA 5JHUA 2BWUA 4R60A 2BWTA 1KQ0A 3BIPA 1WN1A 2V6CA 1WY2A 2Q94A 2V3YA 1XNZA 2GG3A 4IKUA 3IG4A 2BWSA 2GU5A 2ADUA 2Q96A 3FMRA 1B59A 1YW8A 3PKCA 5CDVA 4U6EA 2GG8A 1B6AA 2Q95A 2V3ZA 1W2MA 4U69A 4U70A 1Y1NA 4U6CA 5CNXA 4IKRA 4IF7A 1M35A 1WLRA 2V3XA 4FLKA 2BN7A 1YW7A 2EVMA 1WL9A 2BWVA 4JUQA 3BIQA 4Z7MA 4RGZ1 3MR1A 3CB5A 3Q6DA 3PKDA 2GTXA 1R5GA 1O0XA 1C22A 5D6FA 4IKTA 4IU6A 1BOAA 3BITA 3IU9A 4HXXA 2GU6A 2GGCA 4PNCA 3L7GA 2GG7A 4ZNGA 2IW2A 1A16A 1YW9A 1CHMA 2GG9A 1R58A 4ZWPA 1XGNA 3S6BA 4FLIA 2Q8KA 4S2RP 1XGMA 2GU4A 4IKSA 3CTZA 2BH3A 1YJ3A 2GG0A 2EA4A 2P98A 5FCFA 4KM3A 5CDEA 2ZSGA 1XGOA 3FMQA 4A6VA 4FO8A 2BWYA 5JFRA 3MX6A 4RZYA 3IU7A 2B3LA 2B3KA
chains in the Genus database with same CATH topology
2BHAA 2MATA 5CDLA 2BHDA 4MATA 3L24A 5CLSA 2GG2A 1C24A 2OAZA 4FLLA 2BHBA 5CIKA 3RORA 3D27A 2GA2A 1R5HA 4FO7A 1W7VA 2BWWA 4S2TP 2BWXA 1C23A 4FLJA 3IU8A 2OKNA 1BN5A 4OOKA 2DFIA 4EGEA 4U6JA 3CB6A 2Q93A 4IPAA 4S00A 4U1BA 5D6EA 3PKAA 1JAWA 2GU7A 4U73A 2P9AA 1QXZA 2EA2A 1XGSA 2GZ5A 4QR8A 1N51A 1KQ9A 4U6WA 3TB5A 4U71A 4IECA 4FKCA 4ZWOA 3FM3A 3PKEA 4U76A 1C21A 5JI6A 4ZWUA 2EVCA 2HOWA 2GGBA 4B28A 2Q92A 1MATA 3RVAA 4FUKA 4IDYA 2EVOA 3TAVA 1QXYA 1QZYA 3PKBA 5CE6A 4U75A 1WL6A 4A6WA 3MATA 1YVMA 2BB7A 4RZZA 2B3HA 2NQ6A 5E5BA 1PV9A 1QXWA 2BHCA 2GG5A 1KP0A 5FCHA 1WBQA 2P99A 2G6PA 4S01A 4PV4A 1C27A 1WKMA 2NQ7A 4U6ZA 5JHUA 2BWUA 4R60A 2BWTA 1KQ0A 3BIPA 1WN1A 2V6CA 1WY2A 2Q94A 2V3YA 1XNZA 2GG3A 4IKUA 3IG4A 2BWSA 2GU5A 2ADUA 2Q96A 3FMRA 1B59A 1YW8A 3PKCA 5CDVA 4U6EA 2GG8A 1B6AA 2Q95A 2V3ZA 1W2MA 4U69A 4U70A 1Y1NA 4U6CA 5CNXA 4IKRA 4IF7A 1M35A 1WLRA 2V3XA 4FLKA 2BN7A 1YW7A 2EVMA 1WL9A 2BWVA 4JUQA 3BIQA 4Z7MA 4RGZ1 3MR1A 3CB5A 3Q6DA 3PKDA 2GTXA 1R5GA 1O0XA 1C22A 5D6FA 4IKTA 4IU6A 1BOAA 3BITA 3IU9A 4HXXA 2GU6A 2GGCA 4PNCA 3L7GA 2GG7A 4ZNGA 2IW2A 1A16A 1YW9A 1CHMA 2GG9A 1R58A 4ZWPA 1XGNA 3S6BA 4FLIA 2Q8KA 4S2RP 1XGMA 2GU4A 4IKSA 3CTZA 2BH3A 1YJ3A 2GG0A 2EA4A 2P98A 5FCFA 4KM3A 5CDEA 2ZSGA 1XGOA 3FMQA 4A6VA 4FO8A 2BWYA 5JFRA 3MX6A 4RZYA 3IU7A 2B3LA 2B3KA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2BHA A;  2MAT A;  5CDL A;  2BHD A;  4MAT A;  3L24 A;  5CLS A;  2GG2 A;  1C24 A;  2OAZ A;  4FLL A;  2BHB A;  5CIK A;  3ROR A;  3D27 A;  2GA2 A;  1R5H A;  4FO7 A;  1W7V A;  2BWW A;  4S2T P;  2BWX A;  1C23 A;  4FLJ A;  3IU8 A;  2OKN A;  1BN5 A;  4OOK A;  2DFI A;  4EGE A;  4U6J A;  3CB6 A;  2Q93 A;  4IPA A;  4S00 A;  4U1B A;  5D6E A;  3PKA A;  1JAW A;  2GU7 A;  4U73 A;  2P9A A;  1QXZ A;  2EA2 A;  1XGS A;  2GZ5 A;  4QR8 A;  1N51 A;  1KQ9 A;  4U6W A;  3TB5 A;  4U71 A;  4IEC A;  4FKC A;  4ZWO A;  3FM3 A;  3PKE A;  4U76 A;  1C21 A;  5JI6 A;  4ZWU A;  2EVC A;  2HOW A;  2GGB A;  4B28 A;  2Q92 A;  1MAT A;  3RVA A;  4FUK A;  4IDY A;  2EVO A;  3TAV A;  1QXY A;  1QZY A;  3PKB A;  5CE6 A;  4U75 A;  1WL6 A;  4A6W A;  3MAT A;  1YVM A;  2BB7 A;  4RZZ A;  2B3H A;  2NQ6 A;  5E5B A;  1PV9 A;  1QXW A;  2BHC A;  2GG5 A;  1KP0 A;  5FCH A;  1WBQ A;  2P99 A;  2G6P A;  4S01 A;  4PV4 A;  1C27 A;  1WKM A;  2NQ7 A;  4U6Z A;  5JHU A;  2BWU A;  4R60 A;  2BWT A;  1KQ0 A;  3BIP A;  1WN1 A;  2V6C A;  1WY2 A;  2Q94 A;  2V3Y A;  1XNZ A;  2GG3 A;  4IKU A;  3IG4 A;  2BWS A;  2GU5 A;  2ADU A;  2Q96 A;  3FMR A;  1B59 A;  1YW8 A;  3PKC A;  5CDV A;  4U6E A;  2GG8 A;  1B6A A;  2Q95 A;  2V3Z A;  1W2M A;  4U69 A;  4U70 A;  1Y1N A;  4U6C A;  5CNX A;  4IKR A;  4IF7 A;  1M35 A;  1WLR A;  2V3X A;  4FLK A;  2BN7 A;  1YW7 A;  2EVM A;  1WL9 A;  2BWV A;  4JUQ A;  3BIQ A;  4Z7M A;  4RGZ 1;  3MR1 A;  3CB5 A;  3Q6D A;  3PKD A;  2GTX A;  1R5G A;  1O0X A;  1C22 A;  5D6F A;  4IKT A;  4IU6 A;  1BOA A;  3BIT A;  3IU9 A;  4HXX A;  2GU6 A;  2GGC A;  4PNC A;  3L7G A;  2GG7 A;  4ZNG A;  2IW2 A;  1A16 A;  1YW9 A;  1CHM A;  2GG9 A;  1R58 A;  4ZWP A;  1XGN A;  3S6B A;  4FLI A;  2Q8K A;  4S2R P;  1XGM A;  2GU4 A;  4IKS A;  3CTZ A;  2BH3 A;  1YJ3 A;  2GG0 A;  2EA4 A;  2P98 A;  5FCF A;  4KM3 A;  5CDE A;  2ZSG A;  1XGO A;  3FMQ A;  4A6V A;  4FO8 A;  2BWY A;  5JFR A;  3MX6 A;  4RZY A;  3IU7 A;  2B3L A;  2B3K A; 
#chains in the Genus database with same CATH topology
 2BHA A;  2MAT A;  5CDL A;  2BHD A;  4MAT A;  3L24 A;  5CLS A;  2GG2 A;  1C24 A;  2OAZ A;  4FLL A;  2BHB A;  5CIK A;  3ROR A;  3D27 A;  2GA2 A;  1R5H A;  4FO7 A;  1W7V A;  2BWW A;  4S2T P;  2BWX A;  1C23 A;  4FLJ A;  3IU8 A;  2OKN A;  1BN5 A;  4OOK A;  2DFI A;  4EGE A;  4U6J A;  3CB6 A;  2Q93 A;  4IPA A;  4S00 A;  4U1B A;  5D6E A;  3PKA A;  1JAW A;  2GU7 A;  4U73 A;  2P9A A;  1QXZ A;  2EA2 A;  1XGS A;  2GZ5 A;  4QR8 A;  1N51 A;  1KQ9 A;  4U6W A;  3TB5 A;  4U71 A;  4IEC A;  4FKC A;  4ZWO A;  3FM3 A;  3PKE A;  4U76 A;  1C21 A;  5JI6 A;  4ZWU A;  2EVC A;  2HOW A;  2GGB A;  4B28 A;  2Q92 A;  1MAT A;  3RVA A;  4FUK A;  4IDY A;  2EVO A;  3TAV A;  1QXY A;  1QZY A;  3PKB A;  5CE6 A;  4U75 A;  1WL6 A;  4A6W A;  3MAT A;  1YVM A;  2BB7 A;  4RZZ A;  2B3H A;  2NQ6 A;  5E5B A;  1PV9 A;  1QXW A;  2BHC A;  2GG5 A;  1KP0 A;  5FCH A;  1WBQ A;  2P99 A;  2G6P A;  4S01 A;  4PV4 A;  1C27 A;  1WKM A;  2NQ7 A;  4U6Z A;  5JHU A;  2BWU A;  4R60 A;  2BWT A;  1KQ0 A;  3BIP A;  1WN1 A;  2V6C A;  1WY2 A;  2Q94 A;  2V3Y A;  1XNZ A;  2GG3 A;  4IKU A;  3IG4 A;  2BWS A;  2GU5 A;  2ADU A;  2Q96 A;  3FMR A;  1B59 A;  1YW8 A;  3PKC A;  5CDV A;  4U6E A;  2GG8 A;  1B6A A;  2Q95 A;  2V3Z A;  1W2M A;  4U69 A;  4U70 A;  1Y1N A;  4U6C A;  5CNX A;  4IKR A;  4IF7 A;  1M35 A;  1WLR A;  2V3X A;  4FLK A;  2BN7 A;  1YW7 A;  2EVM A;  1WL9 A;  2BWV A;  4JUQ A;  3BIQ A;  4Z7M A;  4RGZ 1;  3MR1 A;  3CB5 A;  3Q6D A;  3PKD A;  2GTX A;  1R5G A;  1O0X A;  1C22 A;  5D6F A;  4IKT A;  4IU6 A;  1BOA A;  3BIT A;  3IU9 A;  4HXX A;  2GU6 A;  2GGC A;  4PNC A;  3L7G A;  2GG7 A;  4ZNG A;  2IW2 A;  1A16 A;  1YW9 A;  1CHM A;  2GG9 A;  1R58 A;  4ZWP A;  1XGN A;  3S6B A;  4FLI A;  2Q8K A;  4S2R P;  1XGM A;  2GU4 A;  4IKS A;  3CTZ A;  2BH3 A;  1YJ3 A;  2GG0 A;  2EA4 A;  2P98 A;  5FCF A;  4KM3 A;  5CDE A;  2ZSG A;  1XGO A;  3FMQ A;  4A6V A;  4FO8 A;  2BWY A;  5JFR A;  3MX6 A;  4RZY A;  3IU7 A;  2B3L A;  2B3K A; 
#chains in the Genus database with same CATH homology
 2BHA A;  2MAT A;  5CDL A;  2BHD A;  4MAT A;  3L24 A;  5CLS A;  2GG2 A;  1C24 A;  2OAZ A;  4FLL A;  2BHB A;  5CIK A;  3ROR A;  3D27 A;  2GA2 A;  1R5H A;  4FO7 A;  1W7V A;  2BWW A;  4S2T P;  2BWX A;  1C23 A;  4FLJ A;  3IU8 A;  2OKN A;  1BN5 A;  4OOK A;  2DFI A;  4EGE A;  4U6J A;  3CB6 A;  2Q93 A;  4IPA A;  4S00 A;  4U1B A;  5D6E A;  3PKA A;  1JAW A;  2GU7 A;  4U73 A;  2P9A A;  1QXZ A;  2EA2 A;  1XGS A;  2GZ5 A;  4QR8 A;  1N51 A;  1KQ9 A;  4U6W A;  3TB5 A;  4U71 A;  4IEC A;  4FKC A;  4ZWO A;  3FM3 A;  3PKE A;  4U76 A;  1C21 A;  5JI6 A;  4ZWU A;  2EVC A;  2HOW A;  2GGB A;  4B28 A;  2Q92 A;  1MAT A;  3RVA A;  4FUK A;  4IDY A;  2EVO A;  3TAV A;  1QXY A;  1QZY A;  3PKB A;  5CE6 A;  4U75 A;  1WL6 A;  4A6W A;  3MAT A;  1YVM A;  2BB7 A;  4RZZ A;  2B3H A;  2NQ6 A;  5E5B A;  1PV9 A;  1QXW A;  2BHC A;  2GG5 A;  1KP0 A;  5FCH A;  1WBQ A;  2P99 A;  2G6P A;  4S01 A;  4PV4 A;  1C27 A;  1WKM A;  2NQ7 A;  4U6Z A;  5JHU A;  2BWU A;  4R60 A;  2BWT A;  1KQ0 A;  3BIP A;  1WN1 A;  2V6C A;  1WY2 A;  2Q94 A;  2V3Y A;  1XNZ A;  2GG3 A;  4IKU A;  3IG4 A;  2BWS A;  2GU5 A;  2ADU A;  2Q96 A;  3FMR A;  1B59 A;  1YW8 A;  3PKC A;  5CDV A;  4U6E A;  2GG8 A;  1B6A A;  2Q95 A;  2V3Z A;  1W2M A;  4U69 A;  4U70 A;  1Y1N A;  4U6C A;  5CNX A;  4IKR A;  4IF7 A;  1M35 A;  1WLR A;  2V3X A;  4FLK A;  2BN7 A;  1YW7 A;  2EVM A;  1WL9 A;  2BWV A;  4JUQ A;  3BIQ A;  4Z7M A;  4RGZ 1;  3MR1 A;  3CB5 A;  3Q6D A;  3PKD A;  2GTX A;  1R5G A;  1O0X A;  1C22 A;  5D6F A;  4IKT A;  4IU6 A;  1BOA A;  3BIT A;  3IU9 A;  4HXX A;  2GU6 A;  2GGC A;  4PNC A;  3L7G A;  2GG7 A;  4ZNG A;  2IW2 A;  1A16 A;  1YW9 A;  1CHM A;  2GG9 A;  1R58 A;  4ZWP A;  1XGN A;  3S6B A;  4FLI A;  2Q8K A;  4S2R P;  1XGM A;  2GU4 A;  4IKS A;  3CTZ A;  2BH3 A;  1YJ3 A;  2GG0 A;  2EA4 A;  2P98 A;  5FCF A;  4KM3 A;  5CDE A;  2ZSG A;  1XGO A;  3FMQ A;  4A6V A;  4FO8 A;  2BWY A;  5JFR A;  3MX6 A;  4RZY A;  3IU7 A;  2B3L A;  2B3K A;
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...
How to cite