4FLIA

Human metap1 with bengamide analog y16, in mn form
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 100
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fliA00
5D6EA 1KQ0A 4FLLA 1Y1NA 3D27A 2HOWA 4U69A 4IU6A 4U6CA 4U6WA 4OOKA 3TB5A 1QZYA 4FKCA 3MR1A 1M35A 2OKNA 2V3YA 4MATA 4S2TP 5CDVA 2Q95A 4FLKA 4IKSA 4RGZ1 4Z7MA 3IG4A 1YW8A 2BWSA 2P99A 2Q8KA 4S00A 5CLSA 5E5BA 4RZYA 1R5HA 2GG9A 2NQ7A 2GGBA 4R60A 5CE6A 3BIPA 2BHCA 4IPAA 2BWYA 2Q96A 4FLIA 1CHMA 1QXYA 4S01A 1JAWA 2GTXA 2GU4A 1WBQA 1C22A 3Q6DA 4IKTA 1B6AA 2OAZA 2BWTA 3IU8A 2GG8A 4JUQA 1B59A 2BB7A 4RZZA 5CDEA 3S6BA 3CB6A 4U6JA 4FLJA 4IDYA 4U75A 4S2RP 4A6WA 5D6FA 1WL6A 2NQ6A 3FM3A 4IF7A 2Q93A 3MATA 2BWUA 2GU6A 3PKEA 2GG3A 3BITA 2EVMA 2BWWA 3L24A 4U73A 2BWVA 2EVOA 2MATA 2EA4A 4QR8A 4ZNGA 4ZWPA 4IECA 1R5GA 2GG0A 3MX6A 1KQ9A 2GG5A 2GA2A 2GU5A 3RVAA 1XGSA 2ADUA 2ZSGA 1N51A 2P9AA 2Q92A 5CIKA 4HXXA 1A16A 1WKMA 3FMRA 2GG7A 1W2MA 4IKUA 2P98A 1XNZA 4FO7A 5JFRA 4FUKA 1YW9A 5JHUA 1QXWA 3PKCA 1C23A 4U1BA 1XGOA 3IU9A 4PNCA 4EGEA 1XGMA 2V3XA 2EA2A 4ZWOA 2BHBA 3CTZA 1WL9A 2EVCA 1YJ3A 3BIQA 5CDLA 1YW7A 1WY2A 5FCHA 4U76A 1WN1A 1KP0A 2B3LA 3PKAA 2GZ5A 1BOAA 1C21A 1XGNA 3PKBA 3TAVA 2BHDA 4U6ZA 4ZWUA 1MATA 3PKDA 1O0XA 1W7VA 4FO8A 3CB5A 4A6VA 1BN5A 2GG2A 2BH3A 3IU7A 5JI6A 2V6CA 4U70A 5CNXA 4IKRA 1WLRA 2Q94A 1C27A 4U6EA 1R58A 2G6PA 4B28A 4KM3A 2BWXA 2BHAA 2B3KA 1C24A 2GGCA 2V3ZA 1PV9A 1QXZA 1YVMA 2GU7A 5FCFA 3FMQA 4U71A 2BN7A 2IW2A 3L7GA 2B3HA 3RORA 2DFIA 4PV4A
chains in the Genus database with same CATH superfamily
5D6EA 1KQ0A 4FLLA 1Y1NA 3D27A 2HOWA 4U69A 4IU6A 4U6CA 4U6WA 4OOKA 3TB5A 1QZYA 4FKCA 3MR1A 1M35A 2OKNA 2V3YA 4MATA 4S2TP 5CDVA 2Q95A 4FLKA 4IKSA 4RGZ1 4Z7MA 3IG4A 1YW8A 2BWSA 2P99A 2Q8KA 4S00A 5CLSA 5E5BA 4RZYA 1R5HA 2GG9A 2NQ7A 2GGBA 4R60A 5CE6A 3BIPA 2BHCA 4IPAA 2BWYA 2Q96A 4FLIA 1CHMA 1QXYA 4S01A 1JAWA 2GTXA 2GU4A 1WBQA 1C22A 3Q6DA 4IKTA 1B6AA 2OAZA 2BWTA 3IU8A 2GG8A 4JUQA 1B59A 2BB7A 4RZZA 5CDEA 3S6BA 3CB6A 4U6JA 4FLJA 4IDYA 4U75A 4S2RP 4A6WA 5D6FA 1WL6A 2NQ6A 3FM3A 4IF7A 2Q93A 3MATA 2BWUA 2GU6A 3PKEA 2GG3A 3BITA 2EVMA 2BWWA 3L24A 4U73A 2BWVA 2EVOA 2MATA 2EA4A 4QR8A 4ZNGA 4ZWPA 4IECA 1R5GA 2GG0A 3MX6A 1KQ9A 2GG5A 2GA2A 2GU5A 3RVAA 1XGSA 2ADUA 2ZSGA 1N51A 2P9AA 2Q92A 5CIKA 4HXXA 1A16A 1WKMA 3FMRA 2GG7A 1W2MA 4IKUA 2P98A 1XNZA 4FO7A 5JFRA 4FUKA 1YW9A 5JHUA 1QXWA 3PKCA 1C23A 4U1BA 1XGOA 3IU9A 4PNCA 4EGEA 1XGMA 2V3XA 2EA2A 4ZWOA 2BHBA 3CTZA 1WL9A 2EVCA 1YJ3A 3BIQA 5CDLA 1YW7A 1WY2A 5FCHA 4U76A 1WN1A 1KP0A 2B3LA 3PKAA 2GZ5A 1BOAA 1C21A 1XGNA 3PKBA 3TAVA 2BHDA 4U6ZA 4ZWUA 1MATA 3PKDA 1O0XA 1W7VA 4FO8A 3CB5A 4A6VA 1BN5A 2GG2A 2BH3A 3IU7A 5JI6A 2V6CA 4U70A 5CNXA 4IKRA 1WLRA 2Q94A 1C27A 4U6EA 1R58A 2G6PA 4B28A 4KM3A 2BWXA 2BHAA 2B3KA 1C24A 2GGCA 2V3ZA 1PV9A 1QXZA 1YVMA 2GU7A 5FCFA 3FMQA 4U71A 2BN7A 2IW2A 3L7GA 2B3HA 3RORA 2DFIA 4PV4A
chains in the Genus database with same CATH topology
5D6EA 1KQ0A 4FLLA 1Y1NA 3D27A 2HOWA 4U69A 4IU6A 4U6CA 4U6WA 4OOKA 3TB5A 1QZYA 4FKCA 3MR1A 1M35A 2OKNA 2V3YA 4MATA 4S2TP 5CDVA 2Q95A 4FLKA 4IKSA 4RGZ1 4Z7MA 3IG4A 1YW8A 2BWSA 2P99A 2Q8KA 4S00A 5CLSA 5E5BA 4RZYA 1R5HA 2GG9A 2NQ7A 2GGBA 4R60A 5CE6A 3BIPA 2BHCA 4IPAA 2BWYA 2Q96A 4FLIA 1CHMA 1QXYA 4S01A 1JAWA 2GTXA 2GU4A 1WBQA 1C22A 3Q6DA 4IKTA 1B6AA 2OAZA 2BWTA 3IU8A 2GG8A 4JUQA 1B59A 2BB7A 4RZZA 5CDEA 3S6BA 3CB6A 4U6JA 4FLJA 4IDYA 4U75A 4S2RP 4A6WA 5D6FA 1WL6A 2NQ6A 3FM3A 4IF7A 2Q93A 3MATA 2BWUA 2GU6A 3PKEA 2GG3A 3BITA 2EVMA 2BWWA 3L24A 4U73A 2BWVA 2EVOA 2MATA 2EA4A 4QR8A 4ZNGA 4ZWPA 4IECA 1R5GA 2GG0A 3MX6A 1KQ9A 2GG5A 2GA2A 2GU5A 3RVAA 1XGSA 2ADUA 2ZSGA 1N51A 2P9AA 2Q92A 5CIKA 4HXXA 1A16A 1WKMA 3FMRA 2GG7A 1W2MA 4IKUA 2P98A 1XNZA 4FO7A 5JFRA 4FUKA 1YW9A 5JHUA 1QXWA 3PKCA 1C23A 4U1BA 1XGOA 3IU9A 4PNCA 4EGEA 1XGMA 2V3XA 2EA2A 4ZWOA 2BHBA 3CTZA 1WL9A 2EVCA 1YJ3A 3BIQA 5CDLA 1YW7A 1WY2A 5FCHA 4U76A 1WN1A 1KP0A 2B3LA 3PKAA 2GZ5A 1BOAA 1C21A 1XGNA 3PKBA 3TAVA 2BHDA 4U6ZA 4ZWUA 1MATA 3PKDA 1O0XA 1W7VA 4FO8A 3CB5A 4A6VA 1BN5A 2GG2A 2BH3A 3IU7A 5JI6A 2V6CA 4U70A 5CNXA 4IKRA 1WLRA 2Q94A 1C27A 4U6EA 1R58A 2G6PA 4B28A 4KM3A 2BWXA 2BHAA 2B3KA 1C24A 2GGCA 2V3ZA 1PV9A 1QXZA 1YVMA 2GU7A 5FCFA 3FMQA 4U71A 2BN7A 2IW2A 3L7GA 2B3HA 3RORA 2DFIA 4PV4A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5D6E A;  1KQ0 A;  4FLL A;  1Y1N A;  3D27 A;  2HOW A;  4U69 A;  4IU6 A;  4U6C A;  4U6W A;  4OOK A;  3TB5 A;  1QZY A;  4FKC A;  3MR1 A;  1M35 A;  2OKN A;  2V3Y A;  4MAT A;  4S2T P;  5CDV A;  2Q95 A;  4FLK A;  4IKS A;  4RGZ 1;  4Z7M A;  3IG4 A;  1YW8 A;  2BWS A;  2P99 A;  2Q8K A;  4S00 A;  5CLS A;  5E5B A;  4RZY A;  1R5H A;  2GG9 A;  2NQ7 A;  2GGB A;  4R60 A;  5CE6 A;  3BIP A;  2BHC A;  4IPA A;  2BWY A;  2Q96 A;  4FLI A;  1CHM A;  1QXY A;  4S01 A;  1JAW A;  2GTX A;  2GU4 A;  1WBQ A;  1C22 A;  3Q6D A;  4IKT A;  1B6A A;  2OAZ A;  2BWT A;  3IU8 A;  2GG8 A;  4JUQ A;  1B59 A;  2BB7 A;  4RZZ A;  5CDE A;  3S6B A;  3CB6 A;  4U6J A;  4FLJ A;  4IDY A;  4U75 A;  4S2R P;  4A6W A;  5D6F A;  1WL6 A;  2NQ6 A;  3FM3 A;  4IF7 A;  2Q93 A;  3MAT A;  2BWU A;  2GU6 A;  3PKE A;  2GG3 A;  3BIT A;  2EVM A;  2BWW A;  3L24 A;  4U73 A;  2BWV A;  2EVO A;  2MAT A;  2EA4 A;  4QR8 A;  4ZNG A;  4ZWP A;  4IEC A;  1R5G A;  2GG0 A;  3MX6 A;  1KQ9 A;  2GG5 A;  2GA2 A;  2GU5 A;  3RVA A;  1XGS A;  2ADU A;  2ZSG A;  1N51 A;  2P9A A;  2Q92 A;  5CIK A;  4HXX A;  1A16 A;  1WKM A;  3FMR A;  2GG7 A;  1W2M A;  4IKU A;  2P98 A;  1XNZ A;  4FO7 A;  5JFR A;  4FUK A;  1YW9 A;  5JHU A;  1QXW A;  3PKC A;  1C23 A;  4U1B A;  1XGO A;  3IU9 A;  4PNC A;  4EGE A;  1XGM A;  2V3X A;  2EA2 A;  4ZWO A;  2BHB A;  3CTZ A;  1WL9 A;  2EVC A;  1YJ3 A;  3BIQ A;  5CDL A;  1YW7 A;  1WY2 A;  5FCH A;  4U76 A;  1WN1 A;  1KP0 A;  2B3L A;  3PKA A;  2GZ5 A;  1BOA A;  1C21 A;  1XGN A;  3PKB A;  3TAV A;  2BHD A;  4U6Z A;  4ZWU A;  1MAT A;  3PKD A;  1O0X A;  1W7V A;  4FO8 A;  3CB5 A;  4A6V A;  1BN5 A;  2GG2 A;  2BH3 A;  3IU7 A;  5JI6 A;  2V6C A;  4U70 A;  5CNX A;  4IKR A;  1WLR A;  2Q94 A;  1C27 A;  4U6E A;  1R58 A;  2G6P A;  4B28 A;  4KM3 A;  2BWX A;  2BHA A;  2B3K A;  1C24 A;  2GGC A;  2V3Z A;  1PV9 A;  1QXZ A;  1YVM A;  2GU7 A;  5FCF A;  3FMQ A;  4U71 A;  2BN7 A;  2IW2 A;  3L7G A;  2B3H A;  3ROR A;  2DFI A;  4PV4 A; 
#chains in the Genus database with same CATH topology
 5D6E A;  1KQ0 A;  4FLL A;  1Y1N A;  3D27 A;  2HOW A;  4U69 A;  4IU6 A;  4U6C A;  4U6W A;  4OOK A;  3TB5 A;  1QZY A;  4FKC A;  3MR1 A;  1M35 A;  2OKN A;  2V3Y A;  4MAT A;  4S2T P;  5CDV A;  2Q95 A;  4FLK A;  4IKS A;  4RGZ 1;  4Z7M A;  3IG4 A;  1YW8 A;  2BWS A;  2P99 A;  2Q8K A;  4S00 A;  5CLS A;  5E5B A;  4RZY A;  1R5H A;  2GG9 A;  2NQ7 A;  2GGB A;  4R60 A;  5CE6 A;  3BIP A;  2BHC A;  4IPA A;  2BWY A;  2Q96 A;  4FLI A;  1CHM A;  1QXY A;  4S01 A;  1JAW A;  2GTX A;  2GU4 A;  1WBQ A;  1C22 A;  3Q6D A;  4IKT A;  1B6A A;  2OAZ A;  2BWT A;  3IU8 A;  2GG8 A;  4JUQ A;  1B59 A;  2BB7 A;  4RZZ A;  5CDE A;  3S6B A;  3CB6 A;  4U6J A;  4FLJ A;  4IDY A;  4U75 A;  4S2R P;  4A6W A;  5D6F A;  1WL6 A;  2NQ6 A;  3FM3 A;  4IF7 A;  2Q93 A;  3MAT A;  2BWU A;  2GU6 A;  3PKE A;  2GG3 A;  3BIT A;  2EVM A;  2BWW A;  3L24 A;  4U73 A;  2BWV A;  2EVO A;  2MAT A;  2EA4 A;  4QR8 A;  4ZNG A;  4ZWP A;  4IEC A;  1R5G A;  2GG0 A;  3MX6 A;  1KQ9 A;  2GG5 A;  2GA2 A;  2GU5 A;  3RVA A;  1XGS A;  2ADU A;  2ZSG A;  1N51 A;  2P9A A;  2Q92 A;  5CIK A;  4HXX A;  1A16 A;  1WKM A;  3FMR A;  2GG7 A;  1W2M A;  4IKU A;  2P98 A;  1XNZ A;  4FO7 A;  5JFR A;  4FUK A;  1YW9 A;  5JHU A;  1QXW A;  3PKC A;  1C23 A;  4U1B A;  1XGO A;  3IU9 A;  4PNC A;  4EGE A;  1XGM A;  2V3X A;  2EA2 A;  4ZWO A;  2BHB A;  3CTZ A;  1WL9 A;  2EVC A;  1YJ3 A;  3BIQ A;  5CDL A;  1YW7 A;  1WY2 A;  5FCH A;  4U76 A;  1WN1 A;  1KP0 A;  2B3L A;  3PKA A;  2GZ5 A;  1BOA A;  1C21 A;  1XGN A;  3PKB A;  3TAV A;  2BHD A;  4U6Z A;  4ZWU A;  1MAT A;  3PKD A;  1O0X A;  1W7V A;  4FO8 A;  3CB5 A;  4A6V A;  1BN5 A;  2GG2 A;  2BH3 A;  3IU7 A;  5JI6 A;  2V6C A;  4U70 A;  5CNX A;  4IKR A;  1WLR A;  2Q94 A;  1C27 A;  4U6E A;  1R58 A;  2G6P A;  4B28 A;  4KM3 A;  2BWX A;  2BHA A;  2B3K A;  1C24 A;  2GGC A;  2V3Z A;  1PV9 A;  1QXZ A;  1YVM A;  2GU7 A;  5FCF A;  3FMQ A;  4U71 A;  2BN7 A;  2IW2 A;  3L7G A;  2B3H A;  3ROR A;  2DFI A;  4PV4 A; 
#chains in the Genus database with same CATH homology
 5D6E A;  1KQ0 A;  4FLL A;  1Y1N A;  3D27 A;  2HOW A;  4U69 A;  4IU6 A;  4U6C A;  4U6W A;  4OOK A;  3TB5 A;  1QZY A;  4FKC A;  3MR1 A;  1M35 A;  2OKN A;  2V3Y A;  4MAT A;  4S2T P;  5CDV A;  2Q95 A;  4FLK A;  4IKS A;  4RGZ 1;  4Z7M A;  3IG4 A;  1YW8 A;  2BWS A;  2P99 A;  2Q8K A;  4S00 A;  5CLS A;  5E5B A;  4RZY A;  1R5H A;  2GG9 A;  2NQ7 A;  2GGB A;  4R60 A;  5CE6 A;  3BIP A;  2BHC A;  4IPA A;  2BWY A;  2Q96 A;  4FLI A;  1CHM A;  1QXY A;  4S01 A;  1JAW A;  2GTX A;  2GU4 A;  1WBQ A;  1C22 A;  3Q6D A;  4IKT A;  1B6A A;  2OAZ A;  2BWT A;  3IU8 A;  2GG8 A;  4JUQ A;  1B59 A;  2BB7 A;  4RZZ A;  5CDE A;  3S6B A;  3CB6 A;  4U6J A;  4FLJ A;  4IDY A;  4U75 A;  4S2R P;  4A6W A;  5D6F A;  1WL6 A;  2NQ6 A;  3FM3 A;  4IF7 A;  2Q93 A;  3MAT A;  2BWU A;  2GU6 A;  3PKE A;  2GG3 A;  3BIT A;  2EVM A;  2BWW A;  3L24 A;  4U73 A;  2BWV A;  2EVO A;  2MAT A;  2EA4 A;  4QR8 A;  4ZNG A;  4ZWP A;  4IEC A;  1R5G A;  2GG0 A;  3MX6 A;  1KQ9 A;  2GG5 A;  2GA2 A;  2GU5 A;  3RVA A;  1XGS A;  2ADU A;  2ZSG A;  1N51 A;  2P9A A;  2Q92 A;  5CIK A;  4HXX A;  1A16 A;  1WKM A;  3FMR A;  2GG7 A;  1W2M A;  4IKU A;  2P98 A;  1XNZ A;  4FO7 A;  5JFR A;  4FUK A;  1YW9 A;  5JHU A;  1QXW A;  3PKC A;  1C23 A;  4U1B A;  1XGO A;  3IU9 A;  4PNC A;  4EGE A;  1XGM A;  2V3X A;  2EA2 A;  4ZWO A;  2BHB A;  3CTZ A;  1WL9 A;  2EVC A;  1YJ3 A;  3BIQ A;  5CDL A;  1YW7 A;  1WY2 A;  5FCH A;  4U76 A;  1WN1 A;  1KP0 A;  2B3L A;  3PKA A;  2GZ5 A;  1BOA A;  1C21 A;  1XGN A;  3PKB A;  3TAV A;  2BHD A;  4U6Z A;  4ZWU A;  1MAT A;  3PKD A;  1O0X A;  1W7V A;  4FO8 A;  3CB5 A;  4A6V A;  1BN5 A;  2GG2 A;  2BH3 A;  3IU7 A;  5JI6 A;  2V6C A;  4U70 A;  5CNX A;  4IKR A;  1WLR A;  2Q94 A;  1C27 A;  4U6E A;  1R58 A;  2G6P A;  4B28 A;  4KM3 A;  2BWX A;  2BHA A;  2B3K A;  1C24 A;  2GGC A;  2V3Z A;  1PV9 A;  1QXZ A;  1YVM A;  2GU7 A;  5FCF A;  3FMQ A;  4U71 A;  2BN7 A;  2IW2 A;  3L7G A;  2B3H A;  3ROR A;  2DFI A;  4PV4 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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