4FLIA

Human metap1 with bengamide analog y16, in mn form
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 100
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fliA00
2GU7A 2OKNA 2P9AA 2Q95A 1W7VA 2ZSGA 4S00A 4QR8A 2EA2A 2B3KA 4U73A 1B59A 1QXZA 2BHBA 2GG0A 2NQ6A 4IF7A 4FLKA 3TB5A 1MATA 4A6WA 1CHMA 1BOAA 4Z7MA 3BIPA 2BWUA 1B6AA 1XGSA 3FMRA 4JUQA 2GG7A 1BN5A 4IU6A 1QXWA 2GG9A 1QZYA 4U6CA 3Q6DA 4EGEA 5JHUA 4FO7A 2EVMA 5E5BA 3CB5A 3FMQA 1YJ3A 4PV4A 2Q8KA 2GTXA 2GGCA 3MR1A 3D27A 4U71A 5JI6A 1XGNA 2NQ7A 5CDVA 3PKDA 4FKCA 3MATA 1WN1A 4IKSA 4RZZA 4U6JA 3IG4A 1KQ0A 2GA2A 2BWTA 1Y1NA 5CLSA 2GU4A 3PKBA 2V3YA 4FLLA 4U6ZA 4ZWOA 1W2MA 2B3LA 1WL6A 2GG5A 4S2RP 3CTZA 2Q93A 1R5HA 5FCFA 4FO8A 1XNZA 1QXYA 4U70A 2ADUA 5D6EA 2B3HA 4IPAA 4U76A 1R5GA 2BB7A 1WLRA 4R60A 5CNXA 3BIQA 2GG8A 4FUKA 2BWWA 4IECA 2BWYA 3PKEA 3L24A 2BWXA 1O0XA 3IU7A 3RVAA 1R58A 1WL9A 1YVMA 1WY2A 2BWVA 2V3ZA 4ZWPA 1C21A 1XGOA 2BHDA 3L7GA 5D6FA 2G6PA 1PV9A 3MX6A 3CB6A 4S01A 1KP0A 2HOWA 2EA4A 4RGZ1 4IKTA 4U6EA 2GG3A 5CDEA 1C24A 4S2TP 2V3XA 1JAWA 2BHCA 4IDYA 5CIKA 4ZWUA 2Q92A 1N51A 1YW9A 2BN7A 4U75A 1YW8A 4U69A 1C23A 3BITA 3TAVA 2GU5A 3PKAA 4IKUA 1WBQA 2DFIA 4KM3A 5CDLA 2P99A 4FLIA 4U1BA 2BWSA 2GZ5A 1XGMA 1KQ9A 2GU6A 3FM3A 2BH3A 1C22A 4B28A 3IU9A 4IKRA 3PKCA 5JFRA 2P98A 1WKMA 4A6VA 1A16A 4ZNGA 4OOKA 1C27A 2BHAA 2EVOA 4HXXA 4U6WA 2V6CA 5FCHA 2OAZA 3RORA 2GG2A 1YW7A 3IU8A 2Q96A 4RZYA 5CE6A 4MATA 3S6BA 2GGBA 4PNCA 2IW2A 1M35A 2MATA 2Q94A 2EVCA 4FLJA
chains in the Genus database with same CATH superfamily
2GU7A 2OKNA 2P9AA 2Q95A 1W7VA 2ZSGA 4S00A 4QR8A 2EA2A 2B3KA 4U73A 1B59A 1QXZA 2BHBA 2GG0A 2NQ6A 4IF7A 4FLKA 3TB5A 1MATA 4A6WA 1CHMA 1BOAA 4Z7MA 3BIPA 2BWUA 1B6AA 1XGSA 3FMRA 4JUQA 2GG7A 1BN5A 4IU6A 1QXWA 2GG9A 1QZYA 4U6CA 3Q6DA 4EGEA 5JHUA 4FO7A 2EVMA 5E5BA 3CB5A 3FMQA 1YJ3A 4PV4A 2Q8KA 2GTXA 2GGCA 3MR1A 3D27A 4U71A 5JI6A 1XGNA 2NQ7A 5CDVA 3PKDA 4FKCA 3MATA 1WN1A 4IKSA 4RZZA 4U6JA 3IG4A 1KQ0A 2GA2A 2BWTA 1Y1NA 5CLSA 2GU4A 3PKBA 2V3YA 4FLLA 4U6ZA 4ZWOA 1W2MA 2B3LA 1WL6A 2GG5A 4S2RP 3CTZA 2Q93A 1R5HA 5FCFA 4FO8A 1XNZA 1QXYA 4U70A 2ADUA 5D6EA 2B3HA 4IPAA 4U76A 1R5GA 2BB7A 1WLRA 4R60A 5CNXA 3BIQA 2GG8A 4FUKA 2BWWA 4IECA 2BWYA 3PKEA 3L24A 2BWXA 1O0XA 3IU7A 3RVAA 1R58A 1WL9A 1YVMA 1WY2A 2BWVA 2V3ZA 4ZWPA 1C21A 1XGOA 2BHDA 3L7GA 5D6FA 2G6PA 1PV9A 3MX6A 3CB6A 4S01A 1KP0A 2HOWA 2EA4A 4RGZ1 4IKTA 4U6EA 2GG3A 5CDEA 1C24A 4S2TP 2V3XA 1JAWA 2BHCA 4IDYA 5CIKA 4ZWUA 2Q92A 1N51A 1YW9A 2BN7A 4U75A 1YW8A 4U69A 1C23A 3BITA 3TAVA 2GU5A 3PKAA 4IKUA 1WBQA 2DFIA 4KM3A 5CDLA 2P99A 4FLIA 4U1BA 2BWSA 2GZ5A 1XGMA 1KQ9A 2GU6A 3FM3A 2BH3A 1C22A 4B28A 3IU9A 4IKRA 3PKCA 5JFRA 2P98A 1WKMA 4A6VA 1A16A 4ZNGA 4OOKA 1C27A 2BHAA 2EVOA 4HXXA 4U6WA 2V6CA 5FCHA 2OAZA 3RORA 2GG2A 1YW7A 3IU8A 2Q96A 4RZYA 5CE6A 4MATA 3S6BA 2GGBA 4PNCA 2IW2A 1M35A 2MATA 2Q94A 2EVCA 4FLJA
chains in the Genus database with same CATH topology
2GU7A 2OKNA 2P9AA 2Q95A 1W7VA 2ZSGA 4S00A 4QR8A 2EA2A 2B3KA 4U73A 1B59A 1QXZA 2BHBA 2GG0A 2NQ6A 4IF7A 4FLKA 3TB5A 1MATA 4A6WA 1CHMA 1BOAA 4Z7MA 3BIPA 2BWUA 1B6AA 1XGSA 3FMRA 4JUQA 2GG7A 1BN5A 4IU6A 1QXWA 2GG9A 1QZYA 4U6CA 3Q6DA 4EGEA 5JHUA 4FO7A 2EVMA 5E5BA 3CB5A 3FMQA 1YJ3A 4PV4A 2Q8KA 2GTXA 2GGCA 3MR1A 3D27A 4U71A 5JI6A 1XGNA 2NQ7A 5CDVA 3PKDA 4FKCA 3MATA 1WN1A 4IKSA 4RZZA 4U6JA 3IG4A 1KQ0A 2GA2A 2BWTA 1Y1NA 5CLSA 2GU4A 3PKBA 2V3YA 4FLLA 4U6ZA 4ZWOA 1W2MA 2B3LA 1WL6A 2GG5A 4S2RP 3CTZA 2Q93A 1R5HA 5FCFA 4FO8A 1XNZA 1QXYA 4U70A 2ADUA 5D6EA 2B3HA 4IPAA 4U76A 1R5GA 2BB7A 1WLRA 4R60A 5CNXA 3BIQA 2GG8A 4FUKA 2BWWA 4IECA 2BWYA 3PKEA 3L24A 2BWXA 1O0XA 3IU7A 3RVAA 1R58A 1WL9A 1YVMA 1WY2A 2BWVA 2V3ZA 4ZWPA 1C21A 1XGOA 2BHDA 3L7GA 5D6FA 2G6PA 1PV9A 3MX6A 3CB6A 4S01A 1KP0A 2HOWA 2EA4A 4RGZ1 4IKTA 4U6EA 2GG3A 5CDEA 1C24A 4S2TP 2V3XA 1JAWA 2BHCA 4IDYA 5CIKA 4ZWUA 2Q92A 1N51A 1YW9A 2BN7A 4U75A 1YW8A 4U69A 1C23A 3BITA 3TAVA 2GU5A 3PKAA 4IKUA 1WBQA 2DFIA 4KM3A 5CDLA 2P99A 4FLIA 4U1BA 2BWSA 2GZ5A 1XGMA 1KQ9A 2GU6A 3FM3A 2BH3A 1C22A 4B28A 3IU9A 4IKRA 3PKCA 5JFRA 2P98A 1WKMA 4A6VA 1A16A 4ZNGA 4OOKA 1C27A 2BHAA 2EVOA 4HXXA 4U6WA 2V6CA 5FCHA 2OAZA 3RORA 2GG2A 1YW7A 3IU8A 2Q96A 4RZYA 5CE6A 4MATA 3S6BA 2GGBA 4PNCA 2IW2A 1M35A 2MATA 2Q94A 2EVCA 4FLJA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2GU7 A;  2OKN A;  2P9A A;  2Q95 A;  1W7V A;  2ZSG A;  4S00 A;  4QR8 A;  2EA2 A;  2B3K A;  4U73 A;  1B59 A;  1QXZ A;  2BHB A;  2GG0 A;  2NQ6 A;  4IF7 A;  4FLK A;  3TB5 A;  1MAT A;  4A6W A;  1CHM A;  1BOA A;  4Z7M A;  3BIP A;  2BWU A;  1B6A A;  1XGS A;  3FMR A;  4JUQ A;  2GG7 A;  1BN5 A;  4IU6 A;  1QXW A;  2GG9 A;  1QZY A;  4U6C A;  3Q6D A;  4EGE A;  5JHU A;  4FO7 A;  2EVM A;  5E5B A;  3CB5 A;  3FMQ A;  1YJ3 A;  4PV4 A;  2Q8K A;  2GTX A;  2GGC A;  3MR1 A;  3D27 A;  4U71 A;  5JI6 A;  1XGN A;  2NQ7 A;  5CDV A;  3PKD A;  4FKC A;  3MAT A;  1WN1 A;  4IKS A;  4RZZ A;  4U6J A;  3IG4 A;  1KQ0 A;  2GA2 A;  2BWT A;  1Y1N A;  5CLS A;  2GU4 A;  3PKB A;  2V3Y A;  4FLL A;  4U6Z A;  4ZWO A;  1W2M A;  2B3L A;  1WL6 A;  2GG5 A;  4S2R P;  3CTZ A;  2Q93 A;  1R5H A;  5FCF A;  4FO8 A;  1XNZ A;  1QXY A;  4U70 A;  2ADU A;  5D6E A;  2B3H A;  4IPA A;  4U76 A;  1R5G A;  2BB7 A;  1WLR A;  4R60 A;  5CNX A;  3BIQ A;  2GG8 A;  4FUK A;  2BWW A;  4IEC A;  2BWY A;  3PKE A;  3L24 A;  2BWX A;  1O0X A;  3IU7 A;  3RVA A;  1R58 A;  1WL9 A;  1YVM A;  1WY2 A;  2BWV A;  2V3Z A;  4ZWP A;  1C21 A;  1XGO A;  2BHD A;  3L7G A;  5D6F A;  2G6P A;  1PV9 A;  3MX6 A;  3CB6 A;  4S01 A;  1KP0 A;  2HOW A;  2EA4 A;  4RGZ 1;  4IKT A;  4U6E A;  2GG3 A;  5CDE A;  1C24 A;  4S2T P;  2V3X A;  1JAW A;  2BHC A;  4IDY A;  5CIK A;  4ZWU A;  2Q92 A;  1N51 A;  1YW9 A;  2BN7 A;  4U75 A;  1YW8 A;  4U69 A;  1C23 A;  3BIT A;  3TAV A;  2GU5 A;  3PKA A;  4IKU A;  1WBQ A;  2DFI A;  4KM3 A;  5CDL A;  2P99 A;  4FLI A;  4U1B A;  2BWS A;  2GZ5 A;  1XGM A;  1KQ9 A;  2GU6 A;  3FM3 A;  2BH3 A;  1C22 A;  4B28 A;  3IU9 A;  4IKR A;  3PKC A;  5JFR A;  2P98 A;  1WKM A;  4A6V A;  1A16 A;  4ZNG A;  4OOK A;  1C27 A;  2BHA A;  2EVO A;  4HXX A;  4U6W A;  2V6C A;  5FCH A;  2OAZ A;  3ROR A;  2GG2 A;  1YW7 A;  3IU8 A;  2Q96 A;  4RZY A;  5CE6 A;  4MAT A;  3S6B A;  2GGB A;  4PNC A;  2IW2 A;  1M35 A;  2MAT A;  2Q94 A;  2EVC A;  4FLJ A; 
#chains in the Genus database with same CATH topology
 2GU7 A;  2OKN A;  2P9A A;  2Q95 A;  1W7V A;  2ZSG A;  4S00 A;  4QR8 A;  2EA2 A;  2B3K A;  4U73 A;  1B59 A;  1QXZ A;  2BHB A;  2GG0 A;  2NQ6 A;  4IF7 A;  4FLK A;  3TB5 A;  1MAT A;  4A6W A;  1CHM A;  1BOA A;  4Z7M A;  3BIP A;  2BWU A;  1B6A A;  1XGS A;  3FMR A;  4JUQ A;  2GG7 A;  1BN5 A;  4IU6 A;  1QXW A;  2GG9 A;  1QZY A;  4U6C A;  3Q6D A;  4EGE A;  5JHU A;  4FO7 A;  2EVM A;  5E5B A;  3CB5 A;  3FMQ A;  1YJ3 A;  4PV4 A;  2Q8K A;  2GTX A;  2GGC A;  3MR1 A;  3D27 A;  4U71 A;  5JI6 A;  1XGN A;  2NQ7 A;  5CDV A;  3PKD A;  4FKC A;  3MAT A;  1WN1 A;  4IKS A;  4RZZ A;  4U6J A;  3IG4 A;  1KQ0 A;  2GA2 A;  2BWT A;  1Y1N A;  5CLS A;  2GU4 A;  3PKB A;  2V3Y A;  4FLL A;  4U6Z A;  4ZWO A;  1W2M A;  2B3L A;  1WL6 A;  2GG5 A;  4S2R P;  3CTZ A;  2Q93 A;  1R5H A;  5FCF A;  4FO8 A;  1XNZ A;  1QXY A;  4U70 A;  2ADU A;  5D6E A;  2B3H A;  4IPA A;  4U76 A;  1R5G A;  2BB7 A;  1WLR A;  4R60 A;  5CNX A;  3BIQ A;  2GG8 A;  4FUK A;  2BWW A;  4IEC A;  2BWY A;  3PKE A;  3L24 A;  2BWX A;  1O0X A;  3IU7 A;  3RVA A;  1R58 A;  1WL9 A;  1YVM A;  1WY2 A;  2BWV A;  2V3Z A;  4ZWP A;  1C21 A;  1XGO A;  2BHD A;  3L7G A;  5D6F A;  2G6P A;  1PV9 A;  3MX6 A;  3CB6 A;  4S01 A;  1KP0 A;  2HOW A;  2EA4 A;  4RGZ 1;  4IKT A;  4U6E A;  2GG3 A;  5CDE A;  1C24 A;  4S2T P;  2V3X A;  1JAW A;  2BHC A;  4IDY A;  5CIK A;  4ZWU A;  2Q92 A;  1N51 A;  1YW9 A;  2BN7 A;  4U75 A;  1YW8 A;  4U69 A;  1C23 A;  3BIT A;  3TAV A;  2GU5 A;  3PKA A;  4IKU A;  1WBQ A;  2DFI A;  4KM3 A;  5CDL A;  2P99 A;  4FLI A;  4U1B A;  2BWS A;  2GZ5 A;  1XGM A;  1KQ9 A;  2GU6 A;  3FM3 A;  2BH3 A;  1C22 A;  4B28 A;  3IU9 A;  4IKR A;  3PKC A;  5JFR A;  2P98 A;  1WKM A;  4A6V A;  1A16 A;  4ZNG A;  4OOK A;  1C27 A;  2BHA A;  2EVO A;  4HXX A;  4U6W A;  2V6C A;  5FCH A;  2OAZ A;  3ROR A;  2GG2 A;  1YW7 A;  3IU8 A;  2Q96 A;  4RZY A;  5CE6 A;  4MAT A;  3S6B A;  2GGB A;  4PNC A;  2IW2 A;  1M35 A;  2MAT A;  2Q94 A;  2EVC A;  4FLJ A; 
#chains in the Genus database with same CATH homology
 2GU7 A;  2OKN A;  2P9A A;  2Q95 A;  1W7V A;  2ZSG A;  4S00 A;  4QR8 A;  2EA2 A;  2B3K A;  4U73 A;  1B59 A;  1QXZ A;  2BHB A;  2GG0 A;  2NQ6 A;  4IF7 A;  4FLK A;  3TB5 A;  1MAT A;  4A6W A;  1CHM A;  1BOA A;  4Z7M A;  3BIP A;  2BWU A;  1B6A A;  1XGS A;  3FMR A;  4JUQ A;  2GG7 A;  1BN5 A;  4IU6 A;  1QXW A;  2GG9 A;  1QZY A;  4U6C A;  3Q6D A;  4EGE A;  5JHU A;  4FO7 A;  2EVM A;  5E5B A;  3CB5 A;  3FMQ A;  1YJ3 A;  4PV4 A;  2Q8K A;  2GTX A;  2GGC A;  3MR1 A;  3D27 A;  4U71 A;  5JI6 A;  1XGN A;  2NQ7 A;  5CDV A;  3PKD A;  4FKC A;  3MAT A;  1WN1 A;  4IKS A;  4RZZ A;  4U6J A;  3IG4 A;  1KQ0 A;  2GA2 A;  2BWT A;  1Y1N A;  5CLS A;  2GU4 A;  3PKB A;  2V3Y A;  4FLL A;  4U6Z A;  4ZWO A;  1W2M A;  2B3L A;  1WL6 A;  2GG5 A;  4S2R P;  3CTZ A;  2Q93 A;  1R5H A;  5FCF A;  4FO8 A;  1XNZ A;  1QXY A;  4U70 A;  2ADU A;  5D6E A;  2B3H A;  4IPA A;  4U76 A;  1R5G A;  2BB7 A;  1WLR A;  4R60 A;  5CNX A;  3BIQ A;  2GG8 A;  4FUK A;  2BWW A;  4IEC A;  2BWY A;  3PKE A;  3L24 A;  2BWX A;  1O0X A;  3IU7 A;  3RVA A;  1R58 A;  1WL9 A;  1YVM A;  1WY2 A;  2BWV A;  2V3Z A;  4ZWP A;  1C21 A;  1XGO A;  2BHD A;  3L7G A;  5D6F A;  2G6P A;  1PV9 A;  3MX6 A;  3CB6 A;  4S01 A;  1KP0 A;  2HOW A;  2EA4 A;  4RGZ 1;  4IKT A;  4U6E A;  2GG3 A;  5CDE A;  1C24 A;  4S2T P;  2V3X A;  1JAW A;  2BHC A;  4IDY A;  5CIK A;  4ZWU A;  2Q92 A;  1N51 A;  1YW9 A;  2BN7 A;  4U75 A;  1YW8 A;  4U69 A;  1C23 A;  3BIT A;  3TAV A;  2GU5 A;  3PKA A;  4IKU A;  1WBQ A;  2DFI A;  4KM3 A;  5CDL A;  2P99 A;  4FLI A;  4U1B A;  2BWS A;  2GZ5 A;  1XGM A;  1KQ9 A;  2GU6 A;  3FM3 A;  2BH3 A;  1C22 A;  4B28 A;  3IU9 A;  4IKR A;  3PKC A;  5JFR A;  2P98 A;  1WKM A;  4A6V A;  1A16 A;  4ZNG A;  4OOK A;  1C27 A;  2BHA A;  2EVO A;  4HXX A;  4U6W A;  2V6C A;  5FCH A;  2OAZ A;  3ROR A;  2GG2 A;  1YW7 A;  3IU8 A;  2Q96 A;  4RZY A;  5CE6 A;  4MAT A;  3S6B A;  2GGB A;  4PNC A;  2IW2 A;  1M35 A;  2MAT A;  2Q94 A;  2EVC A;  4FLJ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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