4FLIA

Human metap1 with bengamide analog y16, in mn form
Total Genus 100
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
100
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 100
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fliA00
3CTZA 3MR1A 2GU5A 4OOKA 1BOAA 4IKTA 2EVMA 2GTXA 2OAZA 2GGCA 1C24A 1R5HA 2BWSA 2Q94A 2BWTA 4FKCA 5FCHA 3PKAA 1QXYA 4S2TP 4U6WA 2GG8A 4IKUA 4FLIA 4U6ZA 5D6EA 4FLJA 2P98A 1YVMA 2IW2A 2V6CA 2GG2A 2BN7A 3D27A 4PV4A 3TB5A 2BHCA 3MX6A 4A6VA 4IKSA 2G6PA 1QZYA 2HOWA 4A6WA 2Q93A 1KQ9A 2ZSGA 4S00A 1B59A 1B6AA 4MATA 5E5BA 1YW7A 3IG4A 4U70A 1WLRA 1XNZA 1XGNA 3FMRA 2BH3A 2ADUA 4U6CA 3S6BA 1KP0A 4KM3A 3CB6A 3CB5A 4RZZA 4B28A 2NQ6A 4U71A 4IF7A 2GA2A 1YJ3A 1C23A 1QXWA 4R60A 3IU7A 2BHDA 2GU6A 3BITA 4RZYA 1QXZA 4U76A 4ZWUA 1C22A 3PKDA 3FMQA 5CLSA 2BWYA 2GU7A 4IPAA 1R58A 1W7VA 5D6FA 2GG9A 5CNXA 4ZWOA 2V3XA 2BWWA 4FLKA 5FCFA 3PKBA 2B3HA 2NQ7A 2B3KA 3FM3A 1C21A 3RVAA 1C27A 4ZWPA 4IDYA 5CDEA 3MATA 5JHUA 3BIQA 4FLLA 3TAVA 1MATA 1KQ0A 2EVCA 2EA2A 2BWUA 4PNCA 3PKEA 2BWXA 3PKCA 4ZNGA 3Q6DA 1YW9A 4U75A 2Q8KA 1PV9A 4U73A 4JUQA 2BB7A 2GZ5A 2P9AA 4IECA 1WKMA 2GGBA 2GG5A 1W2MA 2Q95A 5JFRA 5CE6A 4S01A 4Z7MA 1XGSA 2GG3A 4EGEA 1WL9A 3IU8A 4FO7A 4HXXA 2Q92A 2DFIA 2V3ZA 1WL6A 2EVOA 1YW8A 2BWVA 1WN1A 4IKRA 3BIPA 4S2RP 1JAWA 1R5GA 2GU4A 1BN5A 2GG0A 4FUKA 1M35A 5CDLA 5JI6A 4RGZ1 4U6EA 3RORA 5CDVA 1A16A 2BHAA 1Y1NA 1XGOA 1XGMA 2EA4A 4IU6A 4U6JA 1WBQA 1WY2A 2GG7A 3L7GA 1CHMA 2MATA 2Q96A 3IU9A 1N51A 2BHBA 4U1BA 3L24A 2B3LA 5CIKA 4QR8A 2V3YA 4FO8A 4U69A 2OKNA 1O0XA 2P99A
chains in the Genus database with same CATH superfamily
3CTZA 3MR1A 2GU5A 4OOKA 1BOAA 4IKTA 2EVMA 2GTXA 2OAZA 2GGCA 1C24A 1R5HA 2BWSA 2Q94A 2BWTA 4FKCA 5FCHA 3PKAA 1QXYA 4S2TP 4U6WA 2GG8A 4IKUA 4FLIA 4U6ZA 5D6EA 4FLJA 2P98A 1YVMA 2IW2A 2V6CA 2GG2A 2BN7A 3D27A 4PV4A 3TB5A 2BHCA 3MX6A 4A6VA 4IKSA 2G6PA 1QZYA 2HOWA 4A6WA 2Q93A 1KQ9A 2ZSGA 4S00A 1B59A 1B6AA 4MATA 5E5BA 1YW7A 3IG4A 4U70A 1WLRA 1XNZA 1XGNA 3FMRA 2BH3A 2ADUA 4U6CA 3S6BA 1KP0A 4KM3A 3CB6A 3CB5A 4RZZA 4B28A 2NQ6A 4U71A 4IF7A 2GA2A 1YJ3A 1C23A 1QXWA 4R60A 3IU7A 2BHDA 2GU6A 3BITA 4RZYA 1QXZA 4U76A 4ZWUA 1C22A 3PKDA 3FMQA 5CLSA 2BWYA 2GU7A 4IPAA 1R58A 1W7VA 5D6FA 2GG9A 5CNXA 4ZWOA 2V3XA 2BWWA 4FLKA 5FCFA 3PKBA 2B3HA 2NQ7A 2B3KA 3FM3A 1C21A 3RVAA 1C27A 4ZWPA 4IDYA 5CDEA 3MATA 5JHUA 3BIQA 4FLLA 3TAVA 1MATA 1KQ0A 2EVCA 2EA2A 2BWUA 4PNCA 3PKEA 2BWXA 3PKCA 4ZNGA 3Q6DA 1YW9A 4U75A 2Q8KA 1PV9A 4U73A 4JUQA 2BB7A 2GZ5A 2P9AA 4IECA 1WKMA 2GGBA 2GG5A 1W2MA 2Q95A 5JFRA 5CE6A 4S01A 4Z7MA 1XGSA 2GG3A 4EGEA 1WL9A 3IU8A 4FO7A 4HXXA 2Q92A 2DFIA 2V3ZA 1WL6A 2EVOA 1YW8A 2BWVA 1WN1A 4IKRA 3BIPA 4S2RP 1JAWA 1R5GA 2GU4A 1BN5A 2GG0A 4FUKA 1M35A 5CDLA 5JI6A 4RGZ1 4U6EA 3RORA 5CDVA 1A16A 2BHAA 1Y1NA 1XGOA 1XGMA 2EA4A 4IU6A 4U6JA 1WBQA 1WY2A 2GG7A 3L7GA 1CHMA 2MATA 2Q96A 3IU9A 1N51A 2BHBA 4U1BA 3L24A 2B3LA 5CIKA 4QR8A 2V3YA 4FO8A 4U69A 2OKNA 1O0XA 2P99A
chains in the Genus database with same CATH topology
3CTZA 3MR1A 2GU5A 4OOKA 1BOAA 4IKTA 2EVMA 2GTXA 2OAZA 2GGCA 1C24A 1R5HA 2BWSA 2Q94A 2BWTA 4FKCA 5FCHA 3PKAA 1QXYA 4S2TP 4U6WA 2GG8A 4IKUA 4FLIA 4U6ZA 5D6EA 4FLJA 2P98A 1YVMA 2IW2A 2V6CA 2GG2A 2BN7A 3D27A 4PV4A 3TB5A 2BHCA 3MX6A 4A6VA 4IKSA 2G6PA 1QZYA 2HOWA 4A6WA 2Q93A 1KQ9A 2ZSGA 4S00A 1B59A 1B6AA 4MATA 5E5BA 1YW7A 3IG4A 4U70A 1WLRA 1XNZA 1XGNA 3FMRA 2BH3A 2ADUA 4U6CA 3S6BA 1KP0A 4KM3A 3CB6A 3CB5A 4RZZA 4B28A 2NQ6A 4U71A 4IF7A 2GA2A 1YJ3A 1C23A 1QXWA 4R60A 3IU7A 2BHDA 2GU6A 3BITA 4RZYA 1QXZA 4U76A 4ZWUA 1C22A 3PKDA 3FMQA 5CLSA 2BWYA 2GU7A 4IPAA 1R58A 1W7VA 5D6FA 2GG9A 5CNXA 4ZWOA 2V3XA 2BWWA 4FLKA 5FCFA 3PKBA 2B3HA 2NQ7A 2B3KA 3FM3A 1C21A 3RVAA 1C27A 4ZWPA 4IDYA 5CDEA 3MATA 5JHUA 3BIQA 4FLLA 3TAVA 1MATA 1KQ0A 2EVCA 2EA2A 2BWUA 4PNCA 3PKEA 2BWXA 3PKCA 4ZNGA 3Q6DA 1YW9A 4U75A 2Q8KA 1PV9A 4U73A 4JUQA 2BB7A 2GZ5A 2P9AA 4IECA 1WKMA 2GGBA 2GG5A 1W2MA 2Q95A 5JFRA 5CE6A 4S01A 4Z7MA 1XGSA 2GG3A 4EGEA 1WL9A 3IU8A 4FO7A 4HXXA 2Q92A 2DFIA 2V3ZA 1WL6A 2EVOA 1YW8A 2BWVA 1WN1A 4IKRA 3BIPA 4S2RP 1JAWA 1R5GA 2GU4A 1BN5A 2GG0A 4FUKA 1M35A 5CDLA 5JI6A 4RGZ1 4U6EA 3RORA 5CDVA 1A16A 2BHAA 1Y1NA 1XGOA 1XGMA 2EA4A 4IU6A 4U6JA 1WBQA 1WY2A 2GG7A 3L7GA 1CHMA 2MATA 2Q96A 3IU9A 1N51A 2BHBA 4U1BA 3L24A 2B3LA 5CIKA 4QR8A 2V3YA 4FO8A 4U69A 2OKNA 1O0XA 2P99A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3CTZ A;  3MR1 A;  2GU5 A;  4OOK A;  1BOA A;  4IKT A;  2EVM A;  2GTX A;  2OAZ A;  2GGC A;  1C24 A;  1R5H A;  2BWS A;  2Q94 A;  2BWT A;  4FKC A;  5FCH A;  3PKA A;  1QXY A;  4S2T P;  4U6W A;  2GG8 A;  4IKU A;  4FLI A;  4U6Z A;  5D6E A;  4FLJ A;  2P98 A;  1YVM A;  2IW2 A;  2V6C A;  2GG2 A;  2BN7 A;  3D27 A;  4PV4 A;  3TB5 A;  2BHC A;  3MX6 A;  4A6V A;  4IKS A;  2G6P A;  1QZY A;  2HOW A;  4A6W A;  2Q93 A;  1KQ9 A;  2ZSG A;  4S00 A;  1B59 A;  1B6A A;  4MAT A;  5E5B A;  1YW7 A;  3IG4 A;  4U70 A;  1WLR A;  1XNZ A;  1XGN A;  3FMR A;  2BH3 A;  2ADU A;  4U6C A;  3S6B A;  1KP0 A;  4KM3 A;  3CB6 A;  3CB5 A;  4RZZ A;  4B28 A;  2NQ6 A;  4U71 A;  4IF7 A;  2GA2 A;  1YJ3 A;  1C23 A;  1QXW A;  4R60 A;  3IU7 A;  2BHD A;  2GU6 A;  3BIT A;  4RZY A;  1QXZ A;  4U76 A;  4ZWU A;  1C22 A;  3PKD A;  3FMQ A;  5CLS A;  2BWY A;  2GU7 A;  4IPA A;  1R58 A;  1W7V A;  5D6F A;  2GG9 A;  5CNX A;  4ZWO A;  2V3X A;  2BWW A;  4FLK A;  5FCF A;  3PKB A;  2B3H A;  2NQ7 A;  2B3K A;  3FM3 A;  1C21 A;  3RVA A;  1C27 A;  4ZWP A;  4IDY A;  5CDE A;  3MAT A;  5JHU A;  3BIQ A;  4FLL A;  3TAV A;  1MAT A;  1KQ0 A;  2EVC A;  2EA2 A;  2BWU A;  4PNC A;  3PKE A;  2BWX A;  3PKC A;  4ZNG A;  3Q6D A;  1YW9 A;  4U75 A;  2Q8K A;  1PV9 A;  4U73 A;  4JUQ A;  2BB7 A;  2GZ5 A;  2P9A A;  4IEC A;  1WKM A;  2GGB A;  2GG5 A;  1W2M A;  2Q95 A;  5JFR A;  5CE6 A;  4S01 A;  4Z7M A;  1XGS A;  2GG3 A;  4EGE A;  1WL9 A;  3IU8 A;  4FO7 A;  4HXX A;  2Q92 A;  2DFI A;  2V3Z A;  1WL6 A;  2EVO A;  1YW8 A;  2BWV A;  1WN1 A;  4IKR A;  3BIP A;  4S2R P;  1JAW A;  1R5G A;  2GU4 A;  1BN5 A;  2GG0 A;  4FUK A;  1M35 A;  5CDL A;  5JI6 A;  4RGZ 1;  4U6E A;  3ROR A;  5CDV A;  1A16 A;  2BHA A;  1Y1N A;  1XGO A;  1XGM A;  2EA4 A;  4IU6 A;  4U6J A;  1WBQ A;  1WY2 A;  2GG7 A;  3L7G A;  1CHM A;  2MAT A;  2Q96 A;  3IU9 A;  1N51 A;  2BHB A;  4U1B A;  3L24 A;  2B3L A;  5CIK A;  4QR8 A;  2V3Y A;  4FO8 A;  4U69 A;  2OKN A;  1O0X A;  2P99 A; 
#chains in the Genus database with same CATH topology
 3CTZ A;  3MR1 A;  2GU5 A;  4OOK A;  1BOA A;  4IKT A;  2EVM A;  2GTX A;  2OAZ A;  2GGC A;  1C24 A;  1R5H A;  2BWS A;  2Q94 A;  2BWT A;  4FKC A;  5FCH A;  3PKA A;  1QXY A;  4S2T P;  4U6W A;  2GG8 A;  4IKU A;  4FLI A;  4U6Z A;  5D6E A;  4FLJ A;  2P98 A;  1YVM A;  2IW2 A;  2V6C A;  2GG2 A;  2BN7 A;  3D27 A;  4PV4 A;  3TB5 A;  2BHC A;  3MX6 A;  4A6V A;  4IKS A;  2G6P A;  1QZY A;  2HOW A;  4A6W A;  2Q93 A;  1KQ9 A;  2ZSG A;  4S00 A;  1B59 A;  1B6A A;  4MAT A;  5E5B A;  1YW7 A;  3IG4 A;  4U70 A;  1WLR A;  1XNZ A;  1XGN A;  3FMR A;  2BH3 A;  2ADU A;  4U6C A;  3S6B A;  1KP0 A;  4KM3 A;  3CB6 A;  3CB5 A;  4RZZ A;  4B28 A;  2NQ6 A;  4U71 A;  4IF7 A;  2GA2 A;  1YJ3 A;  1C23 A;  1QXW A;  4R60 A;  3IU7 A;  2BHD A;  2GU6 A;  3BIT A;  4RZY A;  1QXZ A;  4U76 A;  4ZWU A;  1C22 A;  3PKD A;  3FMQ A;  5CLS A;  2BWY A;  2GU7 A;  4IPA A;  1R58 A;  1W7V A;  5D6F A;  2GG9 A;  5CNX A;  4ZWO A;  2V3X A;  2BWW A;  4FLK A;  5FCF A;  3PKB A;  2B3H A;  2NQ7 A;  2B3K A;  3FM3 A;  1C21 A;  3RVA A;  1C27 A;  4ZWP A;  4IDY A;  5CDE A;  3MAT A;  5JHU A;  3BIQ A;  4FLL A;  3TAV A;  1MAT A;  1KQ0 A;  2EVC A;  2EA2 A;  2BWU A;  4PNC A;  3PKE A;  2BWX A;  3PKC A;  4ZNG A;  3Q6D A;  1YW9 A;  4U75 A;  2Q8K A;  1PV9 A;  4U73 A;  4JUQ A;  2BB7 A;  2GZ5 A;  2P9A A;  4IEC A;  1WKM A;  2GGB A;  2GG5 A;  1W2M A;  2Q95 A;  5JFR A;  5CE6 A;  4S01 A;  4Z7M A;  1XGS A;  2GG3 A;  4EGE A;  1WL9 A;  3IU8 A;  4FO7 A;  4HXX A;  2Q92 A;  2DFI A;  2V3Z A;  1WL6 A;  2EVO A;  1YW8 A;  2BWV A;  1WN1 A;  4IKR A;  3BIP A;  4S2R P;  1JAW A;  1R5G A;  2GU4 A;  1BN5 A;  2GG0 A;  4FUK A;  1M35 A;  5CDL A;  5JI6 A;  4RGZ 1;  4U6E A;  3ROR A;  5CDV A;  1A16 A;  2BHA A;  1Y1N A;  1XGO A;  1XGM A;  2EA4 A;  4IU6 A;  4U6J A;  1WBQ A;  1WY2 A;  2GG7 A;  3L7G A;  1CHM A;  2MAT A;  2Q96 A;  3IU9 A;  1N51 A;  2BHB A;  4U1B A;  3L24 A;  2B3L A;  5CIK A;  4QR8 A;  2V3Y A;  4FO8 A;  4U69 A;  2OKN A;  1O0X A;  2P99 A; 
#chains in the Genus database with same CATH homology
 3CTZ A;  3MR1 A;  2GU5 A;  4OOK A;  1BOA A;  4IKT A;  2EVM A;  2GTX A;  2OAZ A;  2GGC A;  1C24 A;  1R5H A;  2BWS A;  2Q94 A;  2BWT A;  4FKC A;  5FCH A;  3PKA A;  1QXY A;  4S2T P;  4U6W A;  2GG8 A;  4IKU A;  4FLI A;  4U6Z A;  5D6E A;  4FLJ A;  2P98 A;  1YVM A;  2IW2 A;  2V6C A;  2GG2 A;  2BN7 A;  3D27 A;  4PV4 A;  3TB5 A;  2BHC A;  3MX6 A;  4A6V A;  4IKS A;  2G6P A;  1QZY A;  2HOW A;  4A6W A;  2Q93 A;  1KQ9 A;  2ZSG A;  4S00 A;  1B59 A;  1B6A A;  4MAT A;  5E5B A;  1YW7 A;  3IG4 A;  4U70 A;  1WLR A;  1XNZ A;  1XGN A;  3FMR A;  2BH3 A;  2ADU A;  4U6C A;  3S6B A;  1KP0 A;  4KM3 A;  3CB6 A;  3CB5 A;  4RZZ A;  4B28 A;  2NQ6 A;  4U71 A;  4IF7 A;  2GA2 A;  1YJ3 A;  1C23 A;  1QXW A;  4R60 A;  3IU7 A;  2BHD A;  2GU6 A;  3BIT A;  4RZY A;  1QXZ A;  4U76 A;  4ZWU A;  1C22 A;  3PKD A;  3FMQ A;  5CLS A;  2BWY A;  2GU7 A;  4IPA A;  1R58 A;  1W7V A;  5D6F A;  2GG9 A;  5CNX A;  4ZWO A;  2V3X A;  2BWW A;  4FLK A;  5FCF A;  3PKB A;  2B3H A;  2NQ7 A;  2B3K A;  3FM3 A;  1C21 A;  3RVA A;  1C27 A;  4ZWP A;  4IDY A;  5CDE A;  3MAT A;  5JHU A;  3BIQ A;  4FLL A;  3TAV A;  1MAT A;  1KQ0 A;  2EVC A;  2EA2 A;  2BWU A;  4PNC A;  3PKE A;  2BWX A;  3PKC A;  4ZNG A;  3Q6D A;  1YW9 A;  4U75 A;  2Q8K A;  1PV9 A;  4U73 A;  4JUQ A;  2BB7 A;  2GZ5 A;  2P9A A;  4IEC A;  1WKM A;  2GGB A;  2GG5 A;  1W2M A;  2Q95 A;  5JFR A;  5CE6 A;  4S01 A;  4Z7M A;  1XGS A;  2GG3 A;  4EGE A;  1WL9 A;  3IU8 A;  4FO7 A;  4HXX A;  2Q92 A;  2DFI A;  2V3Z A;  1WL6 A;  2EVO A;  1YW8 A;  2BWV A;  1WN1 A;  4IKR A;  3BIP A;  4S2R P;  1JAW A;  1R5G A;  2GU4 A;  1BN5 A;  2GG0 A;  4FUK A;  1M35 A;  5CDL A;  5JI6 A;  4RGZ 1;  4U6E A;  3ROR A;  5CDV A;  1A16 A;  2BHA A;  1Y1N A;  1XGO A;  1XGM A;  2EA4 A;  4IU6 A;  4U6J A;  1WBQ A;  1WY2 A;  2GG7 A;  3L7G A;  1CHM A;  2MAT A;  2Q96 A;  3IU9 A;  1N51 A;  2BHB A;  4U1B A;  3L24 A;  2B3L A;  5CIK A;  4QR8 A;  2V3Y A;  4FO8 A;  4U69 A;  2OKN A;  1O0X A;  2P99 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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