4FLJA

Human metap1 with bengamide analog y08, in mn form
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fljA00
2MATA 1B6AA 4U6ZA 1WN1A 2GGBA 2GU7A 4A6WA 4FO7A 2EVCA 2GZ5A 4ZWOA 2Q92A 4FKCA 2GG3A 1QXWA 3L7GA 2EVMA 2GG8A 2BWUA 4U69A 1C22A 4IDYA 5JI6A 3CB6A 1WL6A 4U6CA 3FMRA 1BN5A 1XGOA 2BWSA 1PV9A 2V3XA 4HXXA 4FLIA 1WLRA 4MATA 4S00A 1C27A 3IG4A 4KM3A 2EA4A 3BIQA 4U75A 5CNXA 2BWYA 1YJ3A 2NQ6A 4RZZA 4U76A 2NQ7A 4OOKA 2BWXA 1R5GA 3FMQA 3PKCA 2GU4A 2GGCA 2GTXA 3FM3A 2B3LA 2G6PA 2BWTA 3RVAA 2GA2A 3PKDA 2OAZA 2GG5A 2V6CA 2BB7A 2BHAA 2ADUA 3CB5A 5JHUA 5D6EA 1JAWA 3D27A 3MX6A 4FLJA 4EGEA 4IKTA 4IPAA 1B59A 5D6FA 1CHMA 4RZYA 2GG2A 2GG7A 1XNZA 1WKMA 3Q6DA 5CDLA 2OKNA 2P9AA 2BHBA 4RGZ1 3RORA 2GG0A 1KQ9A 4R60A 2BH3A 4FO8A 4IKRA 5FCHA 2BHCA 1Y1NA 1N51A 2P99A 1R5HA 2ZSGA 4FLLA 4IECA 4ZNGA 3S6BA 1C24A 2V3YA 4B28A 2GU5A 1R58A 4IKUA 4FLKA 4U71A 2EVOA 1YVMA 2Q94A 1XGMA 4PV4A 3MR1A 4U6WA 4JUQA 1C23A 2V3ZA 1WY2A 5CDVA 4U73A 1XGNA 5CLSA 4IKSA 4IU6A 4ZWPA 3IU8A 4QR8A 2GG9A 5CE6A 3BIPA 4U1BA 1QXYA 1A16A 4U70A 2GU6A 4A6VA 1YW8A 2EA2A 3TAVA 2DFIA 2B3KA 5JFRA 3PKBA 1W7VA 2Q96A 2Q8KA 1XGSA 1YW9A 1KQ0A 3CTZA 3IU9A 4U6JA 4ZWUA 1WL9A 3L24A 2BWWA 4IF7A 3TB5A 4S01A 2B3HA 3MATA 1KP0A 4FUKA 4PNCA 1YW7A 1QZYA 2HOWA 3PKEA 2Q93A 5CIKA 1MATA 4Z7MA 2Q95A 1O0XA 5CDEA 5E5BA 4S2RP 2BHDA 4S2TP 2IW2A 2P98A 2BN7A 4U6EA 1C21A 5FCFA 1M35A 1W2MA 3PKAA 1QXZA 2BWVA 3BITA 1BOAA 3IU7A 1WBQA
chains in the Genus database with same CATH superfamily
2MATA 1B6AA 4U6ZA 1WN1A 2GGBA 2GU7A 4A6WA 4FO7A 2EVCA 2GZ5A 4ZWOA 2Q92A 4FKCA 2GG3A 1QXWA 3L7GA 2EVMA 2GG8A 2BWUA 4U69A 1C22A 4IDYA 5JI6A 3CB6A 1WL6A 4U6CA 3FMRA 1BN5A 1XGOA 2BWSA 1PV9A 2V3XA 4HXXA 4FLIA 1WLRA 4MATA 4S00A 1C27A 3IG4A 4KM3A 2EA4A 3BIQA 4U75A 5CNXA 2BWYA 1YJ3A 2NQ6A 4RZZA 4U76A 2NQ7A 4OOKA 2BWXA 1R5GA 3FMQA 3PKCA 2GU4A 2GGCA 2GTXA 3FM3A 2B3LA 2G6PA 2BWTA 3RVAA 2GA2A 3PKDA 2OAZA 2GG5A 2V6CA 2BB7A 2BHAA 2ADUA 3CB5A 5JHUA 5D6EA 1JAWA 3D27A 3MX6A 4FLJA 4EGEA 4IKTA 4IPAA 1B59A 5D6FA 1CHMA 4RZYA 2GG2A 2GG7A 1XNZA 1WKMA 3Q6DA 5CDLA 2OKNA 2P9AA 2BHBA 4RGZ1 3RORA 2GG0A 1KQ9A 4R60A 2BH3A 4FO8A 4IKRA 5FCHA 2BHCA 1Y1NA 1N51A 2P99A 1R5HA 2ZSGA 4FLLA 4IECA 4ZNGA 3S6BA 1C24A 2V3YA 4B28A 2GU5A 1R58A 4IKUA 4FLKA 4U71A 2EVOA 1YVMA 2Q94A 1XGMA 4PV4A 3MR1A 4U6WA 4JUQA 1C23A 2V3ZA 1WY2A 5CDVA 4U73A 1XGNA 5CLSA 4IKSA 4IU6A 4ZWPA 3IU8A 4QR8A 2GG9A 5CE6A 3BIPA 4U1BA 1QXYA 1A16A 4U70A 2GU6A 4A6VA 1YW8A 2EA2A 3TAVA 2DFIA 2B3KA 5JFRA 3PKBA 1W7VA 2Q96A 2Q8KA 1XGSA 1YW9A 1KQ0A 3CTZA 3IU9A 4U6JA 4ZWUA 1WL9A 3L24A 2BWWA 4IF7A 3TB5A 4S01A 2B3HA 3MATA 1KP0A 4FUKA 4PNCA 1YW7A 1QZYA 2HOWA 3PKEA 2Q93A 5CIKA 1MATA 4Z7MA 2Q95A 1O0XA 5CDEA 5E5BA 4S2RP 2BHDA 4S2TP 2IW2A 2P98A 2BN7A 4U6EA 1C21A 5FCFA 1M35A 1W2MA 3PKAA 1QXZA 2BWVA 3BITA 1BOAA 3IU7A 1WBQA
chains in the Genus database with same CATH topology
2MATA 1B6AA 4U6ZA 1WN1A 2GGBA 2GU7A 4A6WA 4FO7A 2EVCA 2GZ5A 4ZWOA 2Q92A 4FKCA 2GG3A 1QXWA 3L7GA 2EVMA 2GG8A 2BWUA 4U69A 1C22A 4IDYA 5JI6A 3CB6A 1WL6A 4U6CA 3FMRA 1BN5A 1XGOA 2BWSA 1PV9A 2V3XA 4HXXA 4FLIA 1WLRA 4MATA 4S00A 1C27A 3IG4A 4KM3A 2EA4A 3BIQA 4U75A 5CNXA 2BWYA 1YJ3A 2NQ6A 4RZZA 4U76A 2NQ7A 4OOKA 2BWXA 1R5GA 3FMQA 3PKCA 2GU4A 2GGCA 2GTXA 3FM3A 2B3LA 2G6PA 2BWTA 3RVAA 2GA2A 3PKDA 2OAZA 2GG5A 2V6CA 2BB7A 2BHAA 2ADUA 3CB5A 5JHUA 5D6EA 1JAWA 3D27A 3MX6A 4FLJA 4EGEA 4IKTA 4IPAA 1B59A 5D6FA 1CHMA 4RZYA 2GG2A 2GG7A 1XNZA 1WKMA 3Q6DA 5CDLA 2OKNA 2P9AA 2BHBA 4RGZ1 3RORA 2GG0A 1KQ9A 4R60A 2BH3A 4FO8A 4IKRA 5FCHA 2BHCA 1Y1NA 1N51A 2P99A 1R5HA 2ZSGA 4FLLA 4IECA 4ZNGA 3S6BA 1C24A 2V3YA 4B28A 2GU5A 1R58A 4IKUA 4FLKA 4U71A 2EVOA 1YVMA 2Q94A 1XGMA 4PV4A 3MR1A 4U6WA 4JUQA 1C23A 2V3ZA 1WY2A 5CDVA 4U73A 1XGNA 5CLSA 4IKSA 4IU6A 4ZWPA 3IU8A 4QR8A 2GG9A 5CE6A 3BIPA 4U1BA 1QXYA 1A16A 4U70A 2GU6A 4A6VA 1YW8A 2EA2A 3TAVA 2DFIA 2B3KA 5JFRA 3PKBA 1W7VA 2Q96A 2Q8KA 1XGSA 1YW9A 1KQ0A 3CTZA 3IU9A 4U6JA 4ZWUA 1WL9A 3L24A 2BWWA 4IF7A 3TB5A 4S01A 2B3HA 3MATA 1KP0A 4FUKA 4PNCA 1YW7A 1QZYA 2HOWA 3PKEA 2Q93A 5CIKA 1MATA 4Z7MA 2Q95A 1O0XA 5CDEA 5E5BA 4S2RP 2BHDA 4S2TP 2IW2A 2P98A 2BN7A 4U6EA 1C21A 5FCFA 1M35A 1W2MA 3PKAA 1QXZA 2BWVA 3BITA 1BOAA 3IU7A 1WBQA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2MAT A;  1B6A A;  4U6Z A;  1WN1 A;  2GGB A;  2GU7 A;  4A6W A;  4FO7 A;  2EVC A;  2GZ5 A;  4ZWO A;  2Q92 A;  4FKC A;  2GG3 A;  1QXW A;  3L7G A;  2EVM A;  2GG8 A;  2BWU A;  4U69 A;  1C22 A;  4IDY A;  5JI6 A;  3CB6 A;  1WL6 A;  4U6C A;  3FMR A;  1BN5 A;  1XGO A;  2BWS A;  1PV9 A;  2V3X A;  4HXX A;  4FLI A;  1WLR A;  4MAT A;  4S00 A;  1C27 A;  3IG4 A;  4KM3 A;  2EA4 A;  3BIQ A;  4U75 A;  5CNX A;  2BWY A;  1YJ3 A;  2NQ6 A;  4RZZ A;  4U76 A;  2NQ7 A;  4OOK A;  2BWX A;  1R5G A;  3FMQ A;  3PKC A;  2GU4 A;  2GGC A;  2GTX A;  3FM3 A;  2B3L A;  2G6P A;  2BWT A;  3RVA A;  2GA2 A;  3PKD A;  2OAZ A;  2GG5 A;  2V6C A;  2BB7 A;  2BHA A;  2ADU A;  3CB5 A;  5JHU A;  5D6E A;  1JAW A;  3D27 A;  3MX6 A;  4FLJ A;  4EGE A;  4IKT A;  4IPA A;  1B59 A;  5D6F A;  1CHM A;  4RZY A;  2GG2 A;  2GG7 A;  1XNZ A;  1WKM A;  3Q6D A;  5CDL A;  2OKN A;  2P9A A;  2BHB A;  4RGZ 1;  3ROR A;  2GG0 A;  1KQ9 A;  4R60 A;  2BH3 A;  4FO8 A;  4IKR A;  5FCH A;  2BHC A;  1Y1N A;  1N51 A;  2P99 A;  1R5H A;  2ZSG A;  4FLL A;  4IEC A;  4ZNG A;  3S6B A;  1C24 A;  2V3Y A;  4B28 A;  2GU5 A;  1R58 A;  4IKU A;  4FLK A;  4U71 A;  2EVO A;  1YVM A;  2Q94 A;  1XGM A;  4PV4 A;  3MR1 A;  4U6W A;  4JUQ A;  1C23 A;  2V3Z A;  1WY2 A;  5CDV A;  4U73 A;  1XGN A;  5CLS A;  4IKS A;  4IU6 A;  4ZWP A;  3IU8 A;  4QR8 A;  2GG9 A;  5CE6 A;  3BIP A;  4U1B A;  1QXY A;  1A16 A;  4U70 A;  2GU6 A;  4A6V A;  1YW8 A;  2EA2 A;  3TAV A;  2DFI A;  2B3K A;  5JFR A;  3PKB A;  1W7V A;  2Q96 A;  2Q8K A;  1XGS A;  1YW9 A;  1KQ0 A;  3CTZ A;  3IU9 A;  4U6J A;  4ZWU A;  1WL9 A;  3L24 A;  2BWW A;  4IF7 A;  3TB5 A;  4S01 A;  2B3H A;  3MAT A;  1KP0 A;  4FUK A;  4PNC A;  1YW7 A;  1QZY A;  2HOW A;  3PKE A;  2Q93 A;  5CIK A;  1MAT A;  4Z7M A;  2Q95 A;  1O0X A;  5CDE A;  5E5B A;  4S2R P;  2BHD A;  4S2T P;  2IW2 A;  2P98 A;  2BN7 A;  4U6E A;  1C21 A;  5FCF A;  1M35 A;  1W2M A;  3PKA A;  1QXZ A;  2BWV A;  3BIT A;  1BOA A;  3IU7 A;  1WBQ A; 
#chains in the Genus database with same CATH topology
 2MAT A;  1B6A A;  4U6Z A;  1WN1 A;  2GGB A;  2GU7 A;  4A6W A;  4FO7 A;  2EVC A;  2GZ5 A;  4ZWO A;  2Q92 A;  4FKC A;  2GG3 A;  1QXW A;  3L7G A;  2EVM A;  2GG8 A;  2BWU A;  4U69 A;  1C22 A;  4IDY A;  5JI6 A;  3CB6 A;  1WL6 A;  4U6C A;  3FMR A;  1BN5 A;  1XGO A;  2BWS A;  1PV9 A;  2V3X A;  4HXX A;  4FLI A;  1WLR A;  4MAT A;  4S00 A;  1C27 A;  3IG4 A;  4KM3 A;  2EA4 A;  3BIQ A;  4U75 A;  5CNX A;  2BWY A;  1YJ3 A;  2NQ6 A;  4RZZ A;  4U76 A;  2NQ7 A;  4OOK A;  2BWX A;  1R5G A;  3FMQ A;  3PKC A;  2GU4 A;  2GGC A;  2GTX A;  3FM3 A;  2B3L A;  2G6P A;  2BWT A;  3RVA A;  2GA2 A;  3PKD A;  2OAZ A;  2GG5 A;  2V6C A;  2BB7 A;  2BHA A;  2ADU A;  3CB5 A;  5JHU A;  5D6E A;  1JAW A;  3D27 A;  3MX6 A;  4FLJ A;  4EGE A;  4IKT A;  4IPA A;  1B59 A;  5D6F A;  1CHM A;  4RZY A;  2GG2 A;  2GG7 A;  1XNZ A;  1WKM A;  3Q6D A;  5CDL A;  2OKN A;  2P9A A;  2BHB A;  4RGZ 1;  3ROR A;  2GG0 A;  1KQ9 A;  4R60 A;  2BH3 A;  4FO8 A;  4IKR A;  5FCH A;  2BHC A;  1Y1N A;  1N51 A;  2P99 A;  1R5H A;  2ZSG A;  4FLL A;  4IEC A;  4ZNG A;  3S6B A;  1C24 A;  2V3Y A;  4B28 A;  2GU5 A;  1R58 A;  4IKU A;  4FLK A;  4U71 A;  2EVO A;  1YVM A;  2Q94 A;  1XGM A;  4PV4 A;  3MR1 A;  4U6W A;  4JUQ A;  1C23 A;  2V3Z A;  1WY2 A;  5CDV A;  4U73 A;  1XGN A;  5CLS A;  4IKS A;  4IU6 A;  4ZWP A;  3IU8 A;  4QR8 A;  2GG9 A;  5CE6 A;  3BIP A;  4U1B A;  1QXY A;  1A16 A;  4U70 A;  2GU6 A;  4A6V A;  1YW8 A;  2EA2 A;  3TAV A;  2DFI A;  2B3K A;  5JFR A;  3PKB A;  1W7V A;  2Q96 A;  2Q8K A;  1XGS A;  1YW9 A;  1KQ0 A;  3CTZ A;  3IU9 A;  4U6J A;  4ZWU A;  1WL9 A;  3L24 A;  2BWW A;  4IF7 A;  3TB5 A;  4S01 A;  2B3H A;  3MAT A;  1KP0 A;  4FUK A;  4PNC A;  1YW7 A;  1QZY A;  2HOW A;  3PKE A;  2Q93 A;  5CIK A;  1MAT A;  4Z7M A;  2Q95 A;  1O0X A;  5CDE A;  5E5B A;  4S2R P;  2BHD A;  4S2T P;  2IW2 A;  2P98 A;  2BN7 A;  4U6E A;  1C21 A;  5FCF A;  1M35 A;  1W2M A;  3PKA A;  1QXZ A;  2BWV A;  3BIT A;  1BOA A;  3IU7 A;  1WBQ A; 
#chains in the Genus database with same CATH homology
 2MAT A;  1B6A A;  4U6Z A;  1WN1 A;  2GGB A;  2GU7 A;  4A6W A;  4FO7 A;  2EVC A;  2GZ5 A;  4ZWO A;  2Q92 A;  4FKC A;  2GG3 A;  1QXW A;  3L7G A;  2EVM A;  2GG8 A;  2BWU A;  4U69 A;  1C22 A;  4IDY A;  5JI6 A;  3CB6 A;  1WL6 A;  4U6C A;  3FMR A;  1BN5 A;  1XGO A;  2BWS A;  1PV9 A;  2V3X A;  4HXX A;  4FLI A;  1WLR A;  4MAT A;  4S00 A;  1C27 A;  3IG4 A;  4KM3 A;  2EA4 A;  3BIQ A;  4U75 A;  5CNX A;  2BWY A;  1YJ3 A;  2NQ6 A;  4RZZ A;  4U76 A;  2NQ7 A;  4OOK A;  2BWX A;  1R5G A;  3FMQ A;  3PKC A;  2GU4 A;  2GGC A;  2GTX A;  3FM3 A;  2B3L A;  2G6P A;  2BWT A;  3RVA A;  2GA2 A;  3PKD A;  2OAZ A;  2GG5 A;  2V6C A;  2BB7 A;  2BHA A;  2ADU A;  3CB5 A;  5JHU A;  5D6E A;  1JAW A;  3D27 A;  3MX6 A;  4FLJ A;  4EGE A;  4IKT A;  4IPA A;  1B59 A;  5D6F A;  1CHM A;  4RZY A;  2GG2 A;  2GG7 A;  1XNZ A;  1WKM A;  3Q6D A;  5CDL A;  2OKN A;  2P9A A;  2BHB A;  4RGZ 1;  3ROR A;  2GG0 A;  1KQ9 A;  4R60 A;  2BH3 A;  4FO8 A;  4IKR A;  5FCH A;  2BHC A;  1Y1N A;  1N51 A;  2P99 A;  1R5H A;  2ZSG A;  4FLL A;  4IEC A;  4ZNG A;  3S6B A;  1C24 A;  2V3Y A;  4B28 A;  2GU5 A;  1R58 A;  4IKU A;  4FLK A;  4U71 A;  2EVO A;  1YVM A;  2Q94 A;  1XGM A;  4PV4 A;  3MR1 A;  4U6W A;  4JUQ A;  1C23 A;  2V3Z A;  1WY2 A;  5CDV A;  4U73 A;  1XGN A;  5CLS A;  4IKS A;  4IU6 A;  4ZWP A;  3IU8 A;  4QR8 A;  2GG9 A;  5CE6 A;  3BIP A;  4U1B A;  1QXY A;  1A16 A;  4U70 A;  2GU6 A;  4A6V A;  1YW8 A;  2EA2 A;  3TAV A;  2DFI A;  2B3K A;  5JFR A;  3PKB A;  1W7V A;  2Q96 A;  2Q8K A;  1XGS A;  1YW9 A;  1KQ0 A;  3CTZ A;  3IU9 A;  4U6J A;  4ZWU A;  1WL9 A;  3L24 A;  2BWW A;  4IF7 A;  3TB5 A;  4S01 A;  2B3H A;  3MAT A;  1KP0 A;  4FUK A;  4PNC A;  1YW7 A;  1QZY A;  2HOW A;  3PKE A;  2Q93 A;  5CIK A;  1MAT A;  4Z7M A;  2Q95 A;  1O0X A;  5CDE A;  5E5B A;  4S2R P;  2BHD A;  4S2T P;  2IW2 A;  2P98 A;  2BN7 A;  4U6E A;  1C21 A;  5FCF A;  1M35 A;  1W2M A;  3PKA A;  1QXZ A;  2BWV A;  3BIT A;  1BOA A;  3IU7 A;  1WBQ A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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