4FLKA

Human metap1 with bengamide analog y10, in mn form
Total Genus 98
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
98
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
total genus 98
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4flkA00
2P99A 4U75A 3IU8A 5D6FA 5CIKA 1C23A 4FUKA 4QR8A 4OOKA 4U70A 4HXXA 1XGMA 1C21A 2IW2A 4A6VA 3TAVA 2GU6A 4FO8A 3BIPA 4PV4A 1XGOA 3MX6A 2Q95A 1N51A 4IF7A 1WL6A 1YW9A 3PKEA 5FCFA 2OKNA 2V6CA 1WY2A 2B3LA 2EVMA 1WBQA 1QXYA 4IKTA 2ADUA 4FLKA 4S2TP 4ZWUA 2EVCA 1A16A 2GGCA 4IU6A 2BHAA 4RZYA 2BB7A 2GTXA 2Q94A 3RORA 5JI6A 4FLIA 1MATA 1XGSA 2OAZA 5D6EA 1CHMA 2DFIA 4IKRA 2BHCA 2V3XA 1R5GA 2P9AA 3D27A 1M35A 5CDEA 5JHUA 4U1BA 5CDVA 4S01A 2GA2A 4IECA 1XGNA 4S00A 1XNZA 1YW7A 2BWUA 3RVAA 4U6EA 2BWYA 4B28A 1C22A 2Q8KA 2Q96A 4FLJA 4EGEA 4R60A 2BHDA 2HOWA 3FM3A 4U6ZA 1B59A 2GG0A 4FO7A 4ZNGA 1JAWA 1BOAA 2GG7A 2V3YA 1PV9A 4PNCA 2MATA 3S6BA 2BWTA 2NQ7A 1R58A 2GG5A 3IU7A 4U6JA 5E5BA 4IPAA 3TB5A 1WL9A 2BN7A 2GG3A 2B3HA 1YW8A 2BWSA 2EVOA 3FMRA 4U71A 2GG2A 3IG4A 1KP0A 5CNXA 3L24A 1O0XA 2V3ZA 1R5HA 2BWWA 4RGZ1 3MATA 4ZWPA 2BWVA 4A6WA 4U76A 4U69A 2ZSGA 1C27A 1W7VA 1WLRA 4ZWOA 3BITA 4FKCA 2EA4A 5JFRA 2P98A 1QZYA 2BH3A 2BWXA 4MATA 3CB5A 2NQ6A 2G6PA 1Y1NA 1B6AA 4U73A 1BN5A 1KQ0A 3PKDA 1YJ3A 1W2MA 2BHBA 4Z7MA 3MR1A 2GU4A 5CE6A 3PKBA 3IU9A 1WKMA 5CDLA 2Q92A 3BIQA 2Q93A 4FLLA 4KM3A 1C24A 1KQ9A 3CTZA 4JUQA 2GU7A 2B3KA 3L7GA 2GZ5A 3PKAA 5FCHA 3CB6A 4RZZA 1QXWA 2GG9A 1YVMA 2EA2A 2GU5A 4IKUA 4IDYA 1QXZA 1WN1A 3FMQA 4U6CA 5CLSA 4IKSA 2GG8A 3Q6DA 2GGBA 3PKCA 4S2RP 4U6WA
chains in the Genus database with same CATH superfamily
2P99A 4U75A 3IU8A 5D6FA 5CIKA 1C23A 4FUKA 4QR8A 4OOKA 4U70A 4HXXA 1XGMA 1C21A 2IW2A 4A6VA 3TAVA 2GU6A 4FO8A 3BIPA 4PV4A 1XGOA 3MX6A 2Q95A 1N51A 4IF7A 1WL6A 1YW9A 3PKEA 5FCFA 2OKNA 2V6CA 1WY2A 2B3LA 2EVMA 1WBQA 1QXYA 4IKTA 2ADUA 4FLKA 4S2TP 4ZWUA 2EVCA 1A16A 2GGCA 4IU6A 2BHAA 4RZYA 2BB7A 2GTXA 2Q94A 3RORA 5JI6A 4FLIA 1MATA 1XGSA 2OAZA 5D6EA 1CHMA 2DFIA 4IKRA 2BHCA 2V3XA 1R5GA 2P9AA 3D27A 1M35A 5CDEA 5JHUA 4U1BA 5CDVA 4S01A 2GA2A 4IECA 1XGNA 4S00A 1XNZA 1YW7A 2BWUA 3RVAA 4U6EA 2BWYA 4B28A 1C22A 2Q8KA 2Q96A 4FLJA 4EGEA 4R60A 2BHDA 2HOWA 3FM3A 4U6ZA 1B59A 2GG0A 4FO7A 4ZNGA 1JAWA 1BOAA 2GG7A 2V3YA 1PV9A 4PNCA 2MATA 3S6BA 2BWTA 2NQ7A 1R58A 2GG5A 3IU7A 4U6JA 5E5BA 4IPAA 3TB5A 1WL9A 2BN7A 2GG3A 2B3HA 1YW8A 2BWSA 2EVOA 3FMRA 4U71A 2GG2A 3IG4A 1KP0A 5CNXA 3L24A 1O0XA 2V3ZA 1R5HA 2BWWA 4RGZ1 3MATA 4ZWPA 2BWVA 4A6WA 4U76A 4U69A 2ZSGA 1C27A 1W7VA 1WLRA 4ZWOA 3BITA 4FKCA 2EA4A 5JFRA 2P98A 1QZYA 2BH3A 2BWXA 4MATA 3CB5A 2NQ6A 2G6PA 1Y1NA 1B6AA 4U73A 1BN5A 1KQ0A 3PKDA 1YJ3A 1W2MA 2BHBA 4Z7MA 3MR1A 2GU4A 5CE6A 3PKBA 3IU9A 1WKMA 5CDLA 2Q92A 3BIQA 2Q93A 4FLLA 4KM3A 1C24A 1KQ9A 3CTZA 4JUQA 2GU7A 2B3KA 3L7GA 2GZ5A 3PKAA 5FCHA 3CB6A 4RZZA 1QXWA 2GG9A 1YVMA 2EA2A 2GU5A 4IKUA 4IDYA 1QXZA 1WN1A 3FMQA 4U6CA 5CLSA 4IKSA 2GG8A 3Q6DA 2GGBA 3PKCA 4S2RP 4U6WA
chains in the Genus database with same CATH topology
2P99A 4U75A 3IU8A 5D6FA 5CIKA 1C23A 4FUKA 4QR8A 4OOKA 4U70A 4HXXA 1XGMA 1C21A 2IW2A 4A6VA 3TAVA 2GU6A 4FO8A 3BIPA 4PV4A 1XGOA 3MX6A 2Q95A 1N51A 4IF7A 1WL6A 1YW9A 3PKEA 5FCFA 2OKNA 2V6CA 1WY2A 2B3LA 2EVMA 1WBQA 1QXYA 4IKTA 2ADUA 4FLKA 4S2TP 4ZWUA 2EVCA 1A16A 2GGCA 4IU6A 2BHAA 4RZYA 2BB7A 2GTXA 2Q94A 3RORA 5JI6A 4FLIA 1MATA 1XGSA 2OAZA 5D6EA 1CHMA 2DFIA 4IKRA 2BHCA 2V3XA 1R5GA 2P9AA 3D27A 1M35A 5CDEA 5JHUA 4U1BA 5CDVA 4S01A 2GA2A 4IECA 1XGNA 4S00A 1XNZA 1YW7A 2BWUA 3RVAA 4U6EA 2BWYA 4B28A 1C22A 2Q8KA 2Q96A 4FLJA 4EGEA 4R60A 2BHDA 2HOWA 3FM3A 4U6ZA 1B59A 2GG0A 4FO7A 4ZNGA 1JAWA 1BOAA 2GG7A 2V3YA 1PV9A 4PNCA 2MATA 3S6BA 2BWTA 2NQ7A 1R58A 2GG5A 3IU7A 4U6JA 5E5BA 4IPAA 3TB5A 1WL9A 2BN7A 2GG3A 2B3HA 1YW8A 2BWSA 2EVOA 3FMRA 4U71A 2GG2A 3IG4A 1KP0A 5CNXA 3L24A 1O0XA 2V3ZA 1R5HA 2BWWA 4RGZ1 3MATA 4ZWPA 2BWVA 4A6WA 4U76A 4U69A 2ZSGA 1C27A 1W7VA 1WLRA 4ZWOA 3BITA 4FKCA 2EA4A 5JFRA 2P98A 1QZYA 2BH3A 2BWXA 4MATA 3CB5A 2NQ6A 2G6PA 1Y1NA 1B6AA 4U73A 1BN5A 1KQ0A 3PKDA 1YJ3A 1W2MA 2BHBA 4Z7MA 3MR1A 2GU4A 5CE6A 3PKBA 3IU9A 1WKMA 5CDLA 2Q92A 3BIQA 2Q93A 4FLLA 4KM3A 1C24A 1KQ9A 3CTZA 4JUQA 2GU7A 2B3KA 3L7GA 2GZ5A 3PKAA 5FCHA 3CB6A 4RZZA 1QXWA 2GG9A 1YVMA 2EA2A 2GU5A 4IKUA 4IDYA 1QXZA 1WN1A 3FMQA 4U6CA 5CLSA 4IKSA 2GG8A 3Q6DA 2GGBA 3PKCA 4S2RP 4U6WA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2P99 A;  4U75 A;  3IU8 A;  5D6F A;  5CIK A;  1C23 A;  4FUK A;  4QR8 A;  4OOK A;  4U70 A;  4HXX A;  1XGM A;  1C21 A;  2IW2 A;  4A6V A;  3TAV A;  2GU6 A;  4FO8 A;  3BIP A;  4PV4 A;  1XGO A;  3MX6 A;  2Q95 A;  1N51 A;  4IF7 A;  1WL6 A;  1YW9 A;  3PKE A;  5FCF A;  2OKN A;  2V6C A;  1WY2 A;  2B3L A;  2EVM A;  1WBQ A;  1QXY A;  4IKT A;  2ADU A;  4FLK A;  4S2T P;  4ZWU A;  2EVC A;  1A16 A;  2GGC A;  4IU6 A;  2BHA A;  4RZY A;  2BB7 A;  2GTX A;  2Q94 A;  3ROR A;  5JI6 A;  4FLI A;  1MAT A;  1XGS A;  2OAZ A;  5D6E A;  1CHM A;  2DFI A;  4IKR A;  2BHC A;  2V3X A;  1R5G A;  2P9A A;  3D27 A;  1M35 A;  5CDE A;  5JHU A;  4U1B A;  5CDV A;  4S01 A;  2GA2 A;  4IEC A;  1XGN A;  4S00 A;  1XNZ A;  1YW7 A;  2BWU A;  3RVA A;  4U6E A;  2BWY A;  4B28 A;  1C22 A;  2Q8K A;  2Q96 A;  4FLJ A;  4EGE A;  4R60 A;  2BHD A;  2HOW A;  3FM3 A;  4U6Z A;  1B59 A;  2GG0 A;  4FO7 A;  4ZNG A;  1JAW A;  1BOA A;  2GG7 A;  2V3Y A;  1PV9 A;  4PNC A;  2MAT A;  3S6B A;  2BWT A;  2NQ7 A;  1R58 A;  2GG5 A;  3IU7 A;  4U6J A;  5E5B A;  4IPA A;  3TB5 A;  1WL9 A;  2BN7 A;  2GG3 A;  2B3H A;  1YW8 A;  2BWS A;  2EVO A;  3FMR A;  4U71 A;  2GG2 A;  3IG4 A;  1KP0 A;  5CNX A;  3L24 A;  1O0X A;  2V3Z A;  1R5H A;  2BWW A;  4RGZ 1;  3MAT A;  4ZWP A;  2BWV A;  4A6W A;  4U76 A;  4U69 A;  2ZSG A;  1C27 A;  1W7V A;  1WLR A;  4ZWO A;  3BIT A;  4FKC A;  2EA4 A;  5JFR A;  2P98 A;  1QZY A;  2BH3 A;  2BWX A;  4MAT A;  3CB5 A;  2NQ6 A;  2G6P A;  1Y1N A;  1B6A A;  4U73 A;  1BN5 A;  1KQ0 A;  3PKD A;  1YJ3 A;  1W2M A;  2BHB A;  4Z7M A;  3MR1 A;  2GU4 A;  5CE6 A;  3PKB A;  3IU9 A;  1WKM A;  5CDL A;  2Q92 A;  3BIQ A;  2Q93 A;  4FLL A;  4KM3 A;  1C24 A;  1KQ9 A;  3CTZ A;  4JUQ A;  2GU7 A;  2B3K A;  3L7G A;  2GZ5 A;  3PKA A;  5FCH A;  3CB6 A;  4RZZ A;  1QXW A;  2GG9 A;  1YVM A;  2EA2 A;  2GU5 A;  4IKU A;  4IDY A;  1QXZ A;  1WN1 A;  3FMQ A;  4U6C A;  5CLS A;  4IKS A;  2GG8 A;  3Q6D A;  2GGB A;  3PKC A;  4S2R P;  4U6W A; 
#chains in the Genus database with same CATH topology
 2P99 A;  4U75 A;  3IU8 A;  5D6F A;  5CIK A;  1C23 A;  4FUK A;  4QR8 A;  4OOK A;  4U70 A;  4HXX A;  1XGM A;  1C21 A;  2IW2 A;  4A6V A;  3TAV A;  2GU6 A;  4FO8 A;  3BIP A;  4PV4 A;  1XGO A;  3MX6 A;  2Q95 A;  1N51 A;  4IF7 A;  1WL6 A;  1YW9 A;  3PKE A;  5FCF A;  2OKN A;  2V6C A;  1WY2 A;  2B3L A;  2EVM A;  1WBQ A;  1QXY A;  4IKT A;  2ADU A;  4FLK A;  4S2T P;  4ZWU A;  2EVC A;  1A16 A;  2GGC A;  4IU6 A;  2BHA A;  4RZY A;  2BB7 A;  2GTX A;  2Q94 A;  3ROR A;  5JI6 A;  4FLI A;  1MAT A;  1XGS A;  2OAZ A;  5D6E A;  1CHM A;  2DFI A;  4IKR A;  2BHC A;  2V3X A;  1R5G A;  2P9A A;  3D27 A;  1M35 A;  5CDE A;  5JHU A;  4U1B A;  5CDV A;  4S01 A;  2GA2 A;  4IEC A;  1XGN A;  4S00 A;  1XNZ A;  1YW7 A;  2BWU A;  3RVA A;  4U6E A;  2BWY A;  4B28 A;  1C22 A;  2Q8K A;  2Q96 A;  4FLJ A;  4EGE A;  4R60 A;  2BHD A;  2HOW A;  3FM3 A;  4U6Z A;  1B59 A;  2GG0 A;  4FO7 A;  4ZNG A;  1JAW A;  1BOA A;  2GG7 A;  2V3Y A;  1PV9 A;  4PNC A;  2MAT A;  3S6B A;  2BWT A;  2NQ7 A;  1R58 A;  2GG5 A;  3IU7 A;  4U6J A;  5E5B A;  4IPA A;  3TB5 A;  1WL9 A;  2BN7 A;  2GG3 A;  2B3H A;  1YW8 A;  2BWS A;  2EVO A;  3FMR A;  4U71 A;  2GG2 A;  3IG4 A;  1KP0 A;  5CNX A;  3L24 A;  1O0X A;  2V3Z A;  1R5H A;  2BWW A;  4RGZ 1;  3MAT A;  4ZWP A;  2BWV A;  4A6W A;  4U76 A;  4U69 A;  2ZSG A;  1C27 A;  1W7V A;  1WLR A;  4ZWO A;  3BIT A;  4FKC A;  2EA4 A;  5JFR A;  2P98 A;  1QZY A;  2BH3 A;  2BWX A;  4MAT A;  3CB5 A;  2NQ6 A;  2G6P A;  1Y1N A;  1B6A A;  4U73 A;  1BN5 A;  1KQ0 A;  3PKD A;  1YJ3 A;  1W2M A;  2BHB A;  4Z7M A;  3MR1 A;  2GU4 A;  5CE6 A;  3PKB A;  3IU9 A;  1WKM A;  5CDL A;  2Q92 A;  3BIQ A;  2Q93 A;  4FLL A;  4KM3 A;  1C24 A;  1KQ9 A;  3CTZ A;  4JUQ A;  2GU7 A;  2B3K A;  3L7G A;  2GZ5 A;  3PKA A;  5FCH A;  3CB6 A;  4RZZ A;  1QXW A;  2GG9 A;  1YVM A;  2EA2 A;  2GU5 A;  4IKU A;  4IDY A;  1QXZ A;  1WN1 A;  3FMQ A;  4U6C A;  5CLS A;  4IKS A;  2GG8 A;  3Q6D A;  2GGB A;  3PKC A;  4S2R P;  4U6W A; 
#chains in the Genus database with same CATH homology
 2P99 A;  4U75 A;  3IU8 A;  5D6F A;  5CIK A;  1C23 A;  4FUK A;  4QR8 A;  4OOK A;  4U70 A;  4HXX A;  1XGM A;  1C21 A;  2IW2 A;  4A6V A;  3TAV A;  2GU6 A;  4FO8 A;  3BIP A;  4PV4 A;  1XGO A;  3MX6 A;  2Q95 A;  1N51 A;  4IF7 A;  1WL6 A;  1YW9 A;  3PKE A;  5FCF A;  2OKN A;  2V6C A;  1WY2 A;  2B3L A;  2EVM A;  1WBQ A;  1QXY A;  4IKT A;  2ADU A;  4FLK A;  4S2T P;  4ZWU A;  2EVC A;  1A16 A;  2GGC A;  4IU6 A;  2BHA A;  4RZY A;  2BB7 A;  2GTX A;  2Q94 A;  3ROR A;  5JI6 A;  4FLI A;  1MAT A;  1XGS A;  2OAZ A;  5D6E A;  1CHM A;  2DFI A;  4IKR A;  2BHC A;  2V3X A;  1R5G A;  2P9A A;  3D27 A;  1M35 A;  5CDE A;  5JHU A;  4U1B A;  5CDV A;  4S01 A;  2GA2 A;  4IEC A;  1XGN A;  4S00 A;  1XNZ A;  1YW7 A;  2BWU A;  3RVA A;  4U6E A;  2BWY A;  4B28 A;  1C22 A;  2Q8K A;  2Q96 A;  4FLJ A;  4EGE A;  4R60 A;  2BHD A;  2HOW A;  3FM3 A;  4U6Z A;  1B59 A;  2GG0 A;  4FO7 A;  4ZNG A;  1JAW A;  1BOA A;  2GG7 A;  2V3Y A;  1PV9 A;  4PNC A;  2MAT A;  3S6B A;  2BWT A;  2NQ7 A;  1R58 A;  2GG5 A;  3IU7 A;  4U6J A;  5E5B A;  4IPA A;  3TB5 A;  1WL9 A;  2BN7 A;  2GG3 A;  2B3H A;  1YW8 A;  2BWS A;  2EVO A;  3FMR A;  4U71 A;  2GG2 A;  3IG4 A;  1KP0 A;  5CNX A;  3L24 A;  1O0X A;  2V3Z A;  1R5H A;  2BWW A;  4RGZ 1;  3MAT A;  4ZWP A;  2BWV A;  4A6W A;  4U76 A;  4U69 A;  2ZSG A;  1C27 A;  1W7V A;  1WLR A;  4ZWO A;  3BIT A;  4FKC A;  2EA4 A;  5JFR A;  2P98 A;  1QZY A;  2BH3 A;  2BWX A;  4MAT A;  3CB5 A;  2NQ6 A;  2G6P A;  1Y1N A;  1B6A A;  4U73 A;  1BN5 A;  1KQ0 A;  3PKD A;  1YJ3 A;  1W2M A;  2BHB A;  4Z7M A;  3MR1 A;  2GU4 A;  5CE6 A;  3PKB A;  3IU9 A;  1WKM A;  5CDL A;  2Q92 A;  3BIQ A;  2Q93 A;  4FLL A;  4KM3 A;  1C24 A;  1KQ9 A;  3CTZ A;  4JUQ A;  2GU7 A;  2B3K A;  3L7G A;  2GZ5 A;  3PKA A;  5FCH A;  3CB6 A;  4RZZ A;  1QXW A;  2GG9 A;  1YVM A;  2EA2 A;  2GU5 A;  4IKU A;  4IDY A;  1QXZ A;  1WN1 A;  3FMQ A;  4U6C A;  5CLS A;  4IKS A;  2GG8 A;  3Q6D A;  2GGB A;  3PKC A;  4S2R P;  4U6W A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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