4FLLA

Human metap1 with bengamide analog yz6, in mn form
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fllA00
5CDEA 4U73A 2V6CA 2Q92A 4U6EA 4RGZ1 1Y1NA 2BN7A 2GG5A 3FM3A 2GG0A 2Q96A 1JAWA 1WY2A 3IG4A 3BIPA 3PKDA 2GTXA 3PKCA 2BWTA 1B6AA 1YJ3A 2NQ7A 5D6FA 1WKMA 4IPAA 2Q95A 1CHMA 3IU9A 2Q94A 1QXZA 3L24A 4U71A 2GG9A 1C27A 1R5HA 3BIQA 1WBQA 2GGCA 4IKTA 2GG2A 1KQ0A 3D27A 5JI6A 1BOAA 4U76A 2V3ZA 2BH3A 1YW9A 4U6WA 2BHAA 1B59A 2HOWA 1A16A 2BHCA 3CB6A 4FUKA 5CDLA 5E5BA 4U6CA 1KP0A 1W7VA 4ZWUA 3CB5A 4EGEA 5CDVA 2GU6A 1QZYA 4QR8A 1QXWA 2GU5A 4IDYA 2BB7A 2GG7A 3MATA 2G6PA 4HXXA 1C24A 4S2TP 4U6JA 3PKEA 2MATA 4R60A 2B3KA 1C23A 4A6WA 1WL6A 4Z7MA 4S2RP 1W2MA 5FCHA 2P98A 1QXYA 2P99A 4FO7A 2V3XA 1XNZA 1XGMA 5JHUA 1O0XA 3Q6DA 2GU7A 4MATA 2B3LA 2BWVA 2EVMA 1WLRA 2EVCA 2GZ5A 3PKBA 5CE6A 4S00A 4U1BA 1XGOA 5CNXA 2EA2A 3MX6A 2GG3A 2BHDA 1R5GA 1YW8A 5JFRA 4U69A 3PKAA 4RZZA 1WN1A 2V3YA 4FLLA 4IKSA 4OOKA 3CTZA 2B3HA 2P9AA 1C22A 2GGBA 4IKRA 2EA4A 4FLJA 1N51A 1YW7A 4FLIA 4U6ZA 3TB5A 1M35A 1C21A 4PV4A 2ADUA 2BWSA 4RZYA 1YVMA 3FMQA 4S01A 4U75A 3RORA 1PV9A 4PNCA 2IW2A 4FLKA 3BITA 5CLSA 2BHBA 2GG8A 4FKCA 1XGNA 3L7GA 4ZWPA 5D6EA 4IF7A 3RVAA 4A6VA 4ZNGA 2ZSGA 4IU6A 2Q8KA 4U70A 2BWUA 4IECA 1MATA 3MR1A 4JUQA 2NQ6A 2OAZA 4ZWOA 4B28A 3IU8A 4IKUA 1BN5A 2BWWA 2GA2A 3IU7A 1WL9A 3FMRA 2BWXA 4FO8A 1KQ9A 2EVOA 5CIKA 2BWYA 2Q93A 3TAVA 2DFIA 1XGSA 2GU4A 4KM3A 3S6BA 2OKNA 5FCFA 1R58A
chains in the Genus database with same CATH superfamily
5CDEA 4U73A 2V6CA 2Q92A 4U6EA 4RGZ1 1Y1NA 2BN7A 2GG5A 3FM3A 2GG0A 2Q96A 1JAWA 1WY2A 3IG4A 3BIPA 3PKDA 2GTXA 3PKCA 2BWTA 1B6AA 1YJ3A 2NQ7A 5D6FA 1WKMA 4IPAA 2Q95A 1CHMA 3IU9A 2Q94A 1QXZA 3L24A 4U71A 2GG9A 1C27A 1R5HA 3BIQA 1WBQA 2GGCA 4IKTA 2GG2A 1KQ0A 3D27A 5JI6A 1BOAA 4U76A 2V3ZA 2BH3A 1YW9A 4U6WA 2BHAA 1B59A 2HOWA 1A16A 2BHCA 3CB6A 4FUKA 5CDLA 5E5BA 4U6CA 1KP0A 1W7VA 4ZWUA 3CB5A 4EGEA 5CDVA 2GU6A 1QZYA 4QR8A 1QXWA 2GU5A 4IDYA 2BB7A 2GG7A 3MATA 2G6PA 4HXXA 1C24A 4S2TP 4U6JA 3PKEA 2MATA 4R60A 2B3KA 1C23A 4A6WA 1WL6A 4Z7MA 4S2RP 1W2MA 5FCHA 2P98A 1QXYA 2P99A 4FO7A 2V3XA 1XNZA 1XGMA 5JHUA 1O0XA 3Q6DA 2GU7A 4MATA 2B3LA 2BWVA 2EVMA 1WLRA 2EVCA 2GZ5A 3PKBA 5CE6A 4S00A 4U1BA 1XGOA 5CNXA 2EA2A 3MX6A 2GG3A 2BHDA 1R5GA 1YW8A 5JFRA 4U69A 3PKAA 4RZZA 1WN1A 2V3YA 4FLLA 4IKSA 4OOKA 3CTZA 2B3HA 2P9AA 1C22A 2GGBA 4IKRA 2EA4A 4FLJA 1N51A 1YW7A 4FLIA 4U6ZA 3TB5A 1M35A 1C21A 4PV4A 2ADUA 2BWSA 4RZYA 1YVMA 3FMQA 4S01A 4U75A 3RORA 1PV9A 4PNCA 2IW2A 4FLKA 3BITA 5CLSA 2BHBA 2GG8A 4FKCA 1XGNA 3L7GA 4ZWPA 5D6EA 4IF7A 3RVAA 4A6VA 4ZNGA 2ZSGA 4IU6A 2Q8KA 4U70A 2BWUA 4IECA 1MATA 3MR1A 4JUQA 2NQ6A 2OAZA 4ZWOA 4B28A 3IU8A 4IKUA 1BN5A 2BWWA 2GA2A 3IU7A 1WL9A 3FMRA 2BWXA 4FO8A 1KQ9A 2EVOA 5CIKA 2BWYA 2Q93A 3TAVA 2DFIA 1XGSA 2GU4A 4KM3A 3S6BA 2OKNA 5FCFA 1R58A
chains in the Genus database with same CATH topology
5CDEA 4U73A 2V6CA 2Q92A 4U6EA 4RGZ1 1Y1NA 2BN7A 2GG5A 3FM3A 2GG0A 2Q96A 1JAWA 1WY2A 3IG4A 3BIPA 3PKDA 2GTXA 3PKCA 2BWTA 1B6AA 1YJ3A 2NQ7A 5D6FA 1WKMA 4IPAA 2Q95A 1CHMA 3IU9A 2Q94A 1QXZA 3L24A 4U71A 2GG9A 1C27A 1R5HA 3BIQA 1WBQA 2GGCA 4IKTA 2GG2A 1KQ0A 3D27A 5JI6A 1BOAA 4U76A 2V3ZA 2BH3A 1YW9A 4U6WA 2BHAA 1B59A 2HOWA 1A16A 2BHCA 3CB6A 4FUKA 5CDLA 5E5BA 4U6CA 1KP0A 1W7VA 4ZWUA 3CB5A 4EGEA 5CDVA 2GU6A 1QZYA 4QR8A 1QXWA 2GU5A 4IDYA 2BB7A 2GG7A 3MATA 2G6PA 4HXXA 1C24A 4S2TP 4U6JA 3PKEA 2MATA 4R60A 2B3KA 1C23A 4A6WA 1WL6A 4Z7MA 4S2RP 1W2MA 5FCHA 2P98A 1QXYA 2P99A 4FO7A 2V3XA 1XNZA 1XGMA 5JHUA 1O0XA 3Q6DA 2GU7A 4MATA 2B3LA 2BWVA 2EVMA 1WLRA 2EVCA 2GZ5A 3PKBA 5CE6A 4S00A 4U1BA 1XGOA 5CNXA 2EA2A 3MX6A 2GG3A 2BHDA 1R5GA 1YW8A 5JFRA 4U69A 3PKAA 4RZZA 1WN1A 2V3YA 4FLLA 4IKSA 4OOKA 3CTZA 2B3HA 2P9AA 1C22A 2GGBA 4IKRA 2EA4A 4FLJA 1N51A 1YW7A 4FLIA 4U6ZA 3TB5A 1M35A 1C21A 4PV4A 2ADUA 2BWSA 4RZYA 1YVMA 3FMQA 4S01A 4U75A 3RORA 1PV9A 4PNCA 2IW2A 4FLKA 3BITA 5CLSA 2BHBA 2GG8A 4FKCA 1XGNA 3L7GA 4ZWPA 5D6EA 4IF7A 3RVAA 4A6VA 4ZNGA 2ZSGA 4IU6A 2Q8KA 4U70A 2BWUA 4IECA 1MATA 3MR1A 4JUQA 2NQ6A 2OAZA 4ZWOA 4B28A 3IU8A 4IKUA 1BN5A 2BWWA 2GA2A 3IU7A 1WL9A 3FMRA 2BWXA 4FO8A 1KQ9A 2EVOA 5CIKA 2BWYA 2Q93A 3TAVA 2DFIA 1XGSA 2GU4A 4KM3A 3S6BA 2OKNA 5FCFA 1R58A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5CDE A;  4U73 A;  2V6C A;  2Q92 A;  4U6E A;  4RGZ 1;  1Y1N A;  2BN7 A;  2GG5 A;  3FM3 A;  2GG0 A;  2Q96 A;  1JAW A;  1WY2 A;  3IG4 A;  3BIP A;  3PKD A;  2GTX A;  3PKC A;  2BWT A;  1B6A A;  1YJ3 A;  2NQ7 A;  5D6F A;  1WKM A;  4IPA A;  2Q95 A;  1CHM A;  3IU9 A;  2Q94 A;  1QXZ A;  3L24 A;  4U71 A;  2GG9 A;  1C27 A;  1R5H A;  3BIQ A;  1WBQ A;  2GGC A;  4IKT A;  2GG2 A;  1KQ0 A;  3D27 A;  5JI6 A;  1BOA A;  4U76 A;  2V3Z A;  2BH3 A;  1YW9 A;  4U6W A;  2BHA A;  1B59 A;  2HOW A;  1A16 A;  2BHC A;  3CB6 A;  4FUK A;  5CDL A;  5E5B A;  4U6C A;  1KP0 A;  1W7V A;  4ZWU A;  3CB5 A;  4EGE A;  5CDV A;  2GU6 A;  1QZY A;  4QR8 A;  1QXW A;  2GU5 A;  4IDY A;  2BB7 A;  2GG7 A;  3MAT A;  2G6P A;  4HXX A;  1C24 A;  4S2T P;  4U6J A;  3PKE A;  2MAT A;  4R60 A;  2B3K A;  1C23 A;  4A6W A;  1WL6 A;  4Z7M A;  4S2R P;  1W2M A;  5FCH A;  2P98 A;  1QXY A;  2P99 A;  4FO7 A;  2V3X A;  1XNZ A;  1XGM A;  5JHU A;  1O0X A;  3Q6D A;  2GU7 A;  4MAT A;  2B3L A;  2BWV A;  2EVM A;  1WLR A;  2EVC A;  2GZ5 A;  3PKB A;  5CE6 A;  4S00 A;  4U1B A;  1XGO A;  5CNX A;  2EA2 A;  3MX6 A;  2GG3 A;  2BHD A;  1R5G A;  1YW8 A;  5JFR A;  4U69 A;  3PKA A;  4RZZ A;  1WN1 A;  2V3Y A;  4FLL A;  4IKS A;  4OOK A;  3CTZ A;  2B3H A;  2P9A A;  1C22 A;  2GGB A;  4IKR A;  2EA4 A;  4FLJ A;  1N51 A;  1YW7 A;  4FLI A;  4U6Z A;  3TB5 A;  1M35 A;  1C21 A;  4PV4 A;  2ADU A;  2BWS A;  4RZY A;  1YVM A;  3FMQ A;  4S01 A;  4U75 A;  3ROR A;  1PV9 A;  4PNC A;  2IW2 A;  4FLK A;  3BIT A;  5CLS A;  2BHB A;  2GG8 A;  4FKC A;  1XGN A;  3L7G A;  4ZWP A;  5D6E A;  4IF7 A;  3RVA A;  4A6V A;  4ZNG A;  2ZSG A;  4IU6 A;  2Q8K A;  4U70 A;  2BWU A;  4IEC A;  1MAT A;  3MR1 A;  4JUQ A;  2NQ6 A;  2OAZ A;  4ZWO A;  4B28 A;  3IU8 A;  4IKU A;  1BN5 A;  2BWW A;  2GA2 A;  3IU7 A;  1WL9 A;  3FMR A;  2BWX A;  4FO8 A;  1KQ9 A;  2EVO A;  5CIK A;  2BWY A;  2Q93 A;  3TAV A;  2DFI A;  1XGS A;  2GU4 A;  4KM3 A;  3S6B A;  2OKN A;  5FCF A;  1R58 A; 
#chains in the Genus database with same CATH topology
 5CDE A;  4U73 A;  2V6C A;  2Q92 A;  4U6E A;  4RGZ 1;  1Y1N A;  2BN7 A;  2GG5 A;  3FM3 A;  2GG0 A;  2Q96 A;  1JAW A;  1WY2 A;  3IG4 A;  3BIP A;  3PKD A;  2GTX A;  3PKC A;  2BWT A;  1B6A A;  1YJ3 A;  2NQ7 A;  5D6F A;  1WKM A;  4IPA A;  2Q95 A;  1CHM A;  3IU9 A;  2Q94 A;  1QXZ A;  3L24 A;  4U71 A;  2GG9 A;  1C27 A;  1R5H A;  3BIQ A;  1WBQ A;  2GGC A;  4IKT A;  2GG2 A;  1KQ0 A;  3D27 A;  5JI6 A;  1BOA A;  4U76 A;  2V3Z A;  2BH3 A;  1YW9 A;  4U6W A;  2BHA A;  1B59 A;  2HOW A;  1A16 A;  2BHC A;  3CB6 A;  4FUK A;  5CDL A;  5E5B A;  4U6C A;  1KP0 A;  1W7V A;  4ZWU A;  3CB5 A;  4EGE A;  5CDV A;  2GU6 A;  1QZY A;  4QR8 A;  1QXW A;  2GU5 A;  4IDY A;  2BB7 A;  2GG7 A;  3MAT A;  2G6P A;  4HXX A;  1C24 A;  4S2T P;  4U6J A;  3PKE A;  2MAT A;  4R60 A;  2B3K A;  1C23 A;  4A6W A;  1WL6 A;  4Z7M A;  4S2R P;  1W2M A;  5FCH A;  2P98 A;  1QXY A;  2P99 A;  4FO7 A;  2V3X A;  1XNZ A;  1XGM A;  5JHU A;  1O0X A;  3Q6D A;  2GU7 A;  4MAT A;  2B3L A;  2BWV A;  2EVM A;  1WLR A;  2EVC A;  2GZ5 A;  3PKB A;  5CE6 A;  4S00 A;  4U1B A;  1XGO A;  5CNX A;  2EA2 A;  3MX6 A;  2GG3 A;  2BHD A;  1R5G A;  1YW8 A;  5JFR A;  4U69 A;  3PKA A;  4RZZ A;  1WN1 A;  2V3Y A;  4FLL A;  4IKS A;  4OOK A;  3CTZ A;  2B3H A;  2P9A A;  1C22 A;  2GGB A;  4IKR A;  2EA4 A;  4FLJ A;  1N51 A;  1YW7 A;  4FLI A;  4U6Z A;  3TB5 A;  1M35 A;  1C21 A;  4PV4 A;  2ADU A;  2BWS A;  4RZY A;  1YVM A;  3FMQ A;  4S01 A;  4U75 A;  3ROR A;  1PV9 A;  4PNC A;  2IW2 A;  4FLK A;  3BIT A;  5CLS A;  2BHB A;  2GG8 A;  4FKC A;  1XGN A;  3L7G A;  4ZWP A;  5D6E A;  4IF7 A;  3RVA A;  4A6V A;  4ZNG A;  2ZSG A;  4IU6 A;  2Q8K A;  4U70 A;  2BWU A;  4IEC A;  1MAT A;  3MR1 A;  4JUQ A;  2NQ6 A;  2OAZ A;  4ZWO A;  4B28 A;  3IU8 A;  4IKU A;  1BN5 A;  2BWW A;  2GA2 A;  3IU7 A;  1WL9 A;  3FMR A;  2BWX A;  4FO8 A;  1KQ9 A;  2EVO A;  5CIK A;  2BWY A;  2Q93 A;  3TAV A;  2DFI A;  1XGS A;  2GU4 A;  4KM3 A;  3S6B A;  2OKN A;  5FCF A;  1R58 A; 
#chains in the Genus database with same CATH homology
 5CDE A;  4U73 A;  2V6C A;  2Q92 A;  4U6E A;  4RGZ 1;  1Y1N A;  2BN7 A;  2GG5 A;  3FM3 A;  2GG0 A;  2Q96 A;  1JAW A;  1WY2 A;  3IG4 A;  3BIP A;  3PKD A;  2GTX A;  3PKC A;  2BWT A;  1B6A A;  1YJ3 A;  2NQ7 A;  5D6F A;  1WKM A;  4IPA A;  2Q95 A;  1CHM A;  3IU9 A;  2Q94 A;  1QXZ A;  3L24 A;  4U71 A;  2GG9 A;  1C27 A;  1R5H A;  3BIQ A;  1WBQ A;  2GGC A;  4IKT A;  2GG2 A;  1KQ0 A;  3D27 A;  5JI6 A;  1BOA A;  4U76 A;  2V3Z A;  2BH3 A;  1YW9 A;  4U6W A;  2BHA A;  1B59 A;  2HOW A;  1A16 A;  2BHC A;  3CB6 A;  4FUK A;  5CDL A;  5E5B A;  4U6C A;  1KP0 A;  1W7V A;  4ZWU A;  3CB5 A;  4EGE A;  5CDV A;  2GU6 A;  1QZY A;  4QR8 A;  1QXW A;  2GU5 A;  4IDY A;  2BB7 A;  2GG7 A;  3MAT A;  2G6P A;  4HXX A;  1C24 A;  4S2T P;  4U6J A;  3PKE A;  2MAT A;  4R60 A;  2B3K A;  1C23 A;  4A6W A;  1WL6 A;  4Z7M A;  4S2R P;  1W2M A;  5FCH A;  2P98 A;  1QXY A;  2P99 A;  4FO7 A;  2V3X A;  1XNZ A;  1XGM A;  5JHU A;  1O0X A;  3Q6D A;  2GU7 A;  4MAT A;  2B3L A;  2BWV A;  2EVM A;  1WLR A;  2EVC A;  2GZ5 A;  3PKB A;  5CE6 A;  4S00 A;  4U1B A;  1XGO A;  5CNX A;  2EA2 A;  3MX6 A;  2GG3 A;  2BHD A;  1R5G A;  1YW8 A;  5JFR A;  4U69 A;  3PKA A;  4RZZ A;  1WN1 A;  2V3Y A;  4FLL A;  4IKS A;  4OOK A;  3CTZ A;  2B3H A;  2P9A A;  1C22 A;  2GGB A;  4IKR A;  2EA4 A;  4FLJ A;  1N51 A;  1YW7 A;  4FLI A;  4U6Z A;  3TB5 A;  1M35 A;  1C21 A;  4PV4 A;  2ADU A;  2BWS A;  4RZY A;  1YVM A;  3FMQ A;  4S01 A;  4U75 A;  3ROR A;  1PV9 A;  4PNC A;  2IW2 A;  4FLK A;  3BIT A;  5CLS A;  2BHB A;  2GG8 A;  4FKC A;  1XGN A;  3L7G A;  4ZWP A;  5D6E A;  4IF7 A;  3RVA A;  4A6V A;  4ZNG A;  2ZSG A;  4IU6 A;  2Q8K A;  4U70 A;  2BWU A;  4IEC A;  1MAT A;  3MR1 A;  4JUQ A;  2NQ6 A;  2OAZ A;  4ZWO A;  4B28 A;  3IU8 A;  4IKU A;  1BN5 A;  2BWW A;  2GA2 A;  3IU7 A;  1WL9 A;  3FMR A;  2BWX A;  4FO8 A;  1KQ9 A;  2EVO A;  5CIK A;  2BWY A;  2Q93 A;  3TAV A;  2DFI A;  1XGS A;  2GU4 A;  4KM3 A;  3S6B A;  2OKN A;  5FCF A;  1R58 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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