4IF7A

Mycobacterium tuberculosis methionine aminopeptidase type 1c in complex with homocysteine-methyl disulfide
Total Genus 86
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
86
sequence length
282
structure length
281
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Mycobacterium tuberculosis
publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 2
total genus 86
structure length 281
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4if7A01
2DFIA 4IECA 4S01A 3TB5A 2Q96A 4A6WA 4ZWUA 3BIPA 4U1BA 3IU9A 2GGBA 4OOKA 2BN7A 4FO8A 2BHAA 3FMRA 1XGMA 2BHBA 1A16A 2G6PA 2Q95A 4FO7A 5JFRA 2B3HA 2BB7A 5D6FA 3CTZA 2EVMA 3PKDA 4IKSA 4IKTA 1C24A 1WY2A 2GG7A 4A6VA 1R5HA 5CE6A 1WL6A 3TAVA 4Z7MA 2P99A 4ZWOA 4PV4A 3RVAA 2BWUA 2EVOA 2GG9A 3L24A 4U6WA 1BOAA 3S6BA 3CB6A 1PV9A 1O0XA 4RGZ1 2IW2A 2HOWA 2V3XA 1KP0A 4KM3A 1XGSA 2Q92A 4S2TP 3IG4A 2GU6A 2OAZA 3BIQA 1WLRA 2BWYA 3PKAA 2BH3A 4FLKA 1WKMA 5D6EA 5JI6A 1WN1A 2NQ6A 5CIKA 3L7GA 4U6EA 3PKEA 3FMQA 3IU8A 3Q6DA 1XGNA 1C27A 1B6AA 1KQ9A 1Y1NA 2GU4A 2NQ7A 4R60A 1QZYA 1C21A 1QXWA 2GG5A 3PKBA 4RZYA 5E5BA 4FLLA 5CDEA 5CDVA 1BN5A 4U75A 2GG3A 2B3LA 2V6CA 1C22A 1KQ0A 4RZZA 4U71A 2ADUA 1CHMA 2B3KA 2V3ZA 4IU6A 5CDLA 1YW8A 1R58A 2EVCA 2Q94A 4ZWPA 1YW7A 1W2MA 3IU7A 4FLJA 3FM3A 2P98A 2BWSA 1YJ3A 2GG2A 2BWXA 2GG8A 4U76A 1B59A 1XGOA 2OKNA 2BHCA 4FLIA 2GZ5A 3RORA 4IKRA 4U69A 5FCFA 4U6JA 1QXZA 5FCHA 2BWTA 4IKUA 2ZSGA 4B28A 2BWWA 2GA2A 3MX6A 5CNXA 1N51A 2GU7A 2Q8KA 5JHUA 1YW9A 1QXYA 2GTXA 4S00A 4EGEA 3MATA 2EA4A 4U6ZA 3D27A 4IF7A 2BHDA 1C23A 1M35A 1YVMA 1MATA 3PKCA 4JUQA 4IPAA 1JAWA 1W7VA 1R5GA 4U73A 4FUKA 2MATA 4ZNGA 2P9AA 2Q93A 4QR8A 4HXXA 4PNCA 3MR1A 4S2RP 1WBQA 5CLSA 4U70A 4FKCA 4IDYA 2V3YA 4MATA 3BITA 2EA2A 2GGCA 4U6CA 2BWVA 1XNZA 2GU5A 1WL9A 2GG0A 3CB5A
chains in the Genus database with same CATH superfamily
2DFIA 4IECA 4S01A 3TB5A 2Q96A 4A6WA 4ZWUA 3BIPA 4U1BA 3IU9A 2GGBA 4OOKA 2BN7A 4FO8A 2BHAA 3FMRA 1XGMA 2BHBA 1A16A 2G6PA 2Q95A 4FO7A 5JFRA 2B3HA 2BB7A 5D6FA 3CTZA 2EVMA 3PKDA 4IKSA 4IKTA 1C24A 1WY2A 2GG7A 4A6VA 1R5HA 5CE6A 1WL6A 3TAVA 4Z7MA 2P99A 4ZWOA 4PV4A 3RVAA 2BWUA 2EVOA 2GG9A 3L24A 4U6WA 1BOAA 3S6BA 3CB6A 1PV9A 1O0XA 4RGZ1 2IW2A 2HOWA 2V3XA 1KP0A 4KM3A 1XGSA 2Q92A 4S2TP 3IG4A 2GU6A 2OAZA 3BIQA 1WLRA 2BWYA 3PKAA 2BH3A 4FLKA 1WKMA 5D6EA 5JI6A 1WN1A 2NQ6A 5CIKA 3L7GA 4U6EA 3PKEA 3FMQA 3IU8A 3Q6DA 1XGNA 1C27A 1B6AA 1KQ9A 1Y1NA 2GU4A 2NQ7A 4R60A 1QZYA 1C21A 1QXWA 2GG5A 3PKBA 4RZYA 5E5BA 4FLLA 5CDEA 5CDVA 1BN5A 4U75A 2GG3A 2B3LA 2V6CA 1C22A 1KQ0A 4RZZA 4U71A 2ADUA 1CHMA 2B3KA 2V3ZA 4IU6A 5CDLA 1YW8A 1R58A 2EVCA 2Q94A 4ZWPA 1YW7A 1W2MA 3IU7A 4FLJA 3FM3A 2P98A 2BWSA 1YJ3A 2GG2A 2BWXA 2GG8A 4U76A 1B59A 1XGOA 2OKNA 2BHCA 4FLIA 2GZ5A 3RORA 4IKRA 4U69A 5FCFA 4U6JA 1QXZA 5FCHA 2BWTA 4IKUA 2ZSGA 4B28A 2BWWA 2GA2A 3MX6A 5CNXA 1N51A 2GU7A 2Q8KA 5JHUA 1YW9A 1QXYA 2GTXA 4S00A 4EGEA 3MATA 2EA4A 4U6ZA 3D27A 4IF7A 2BHDA 1C23A 1M35A 1YVMA 1MATA 3PKCA 4JUQA 4IPAA 1JAWA 1W7VA 1R5GA 4U73A 4FUKA 2MATA 4ZNGA 2P9AA 2Q93A 4QR8A 4HXXA 4PNCA 3MR1A 4S2RP 1WBQA 5CLSA 4U70A 4FKCA 4IDYA 2V3YA 4MATA 3BITA 2EA2A 2GGCA 4U6CA 2BWVA 1XNZA 2GU5A 1WL9A 2GG0A 3CB5A
chains in the Genus database with same CATH topology
2DFIA 4IECA 4S01A 3TB5A 2Q96A 4A6WA 4ZWUA 3BIPA 4U1BA 3IU9A 2GGBA 4OOKA 2BN7A 4FO8A 2BHAA 3FMRA 1XGMA 2BHBA 1A16A 2G6PA 2Q95A 4FO7A 5JFRA 2B3HA 2BB7A 5D6FA 3CTZA 2EVMA 3PKDA 4IKSA 4IKTA 1C24A 1WY2A 2GG7A 4A6VA 1R5HA 5CE6A 1WL6A 3TAVA 4Z7MA 2P99A 4ZWOA 4PV4A 3RVAA 2BWUA 2EVOA 2GG9A 3L24A 4U6WA 1BOAA 3S6BA 3CB6A 1PV9A 1O0XA 4RGZ1 2IW2A 2HOWA 2V3XA 1KP0A 4KM3A 1XGSA 2Q92A 4S2TP 3IG4A 2GU6A 2OAZA 3BIQA 1WLRA 2BWYA 3PKAA 2BH3A 4FLKA 1WKMA 5D6EA 5JI6A 1WN1A 2NQ6A 5CIKA 3L7GA 4U6EA 3PKEA 3FMQA 3IU8A 3Q6DA 1XGNA 1C27A 1B6AA 1KQ9A 1Y1NA 2GU4A 2NQ7A 4R60A 1QZYA 1C21A 1QXWA 2GG5A 3PKBA 4RZYA 5E5BA 4FLLA 5CDEA 5CDVA 1BN5A 4U75A 2GG3A 2B3LA 2V6CA 1C22A 1KQ0A 4RZZA 4U71A 2ADUA 1CHMA 2B3KA 2V3ZA 4IU6A 5CDLA 1YW8A 1R58A 2EVCA 2Q94A 4ZWPA 1YW7A 1W2MA 3IU7A 4FLJA 3FM3A 2P98A 2BWSA 1YJ3A 2GG2A 2BWXA 2GG8A 4U76A 1B59A 1XGOA 2OKNA 2BHCA 4FLIA 2GZ5A 3RORA 4IKRA 4U69A 5FCFA 4U6JA 1QXZA 5FCHA 2BWTA 4IKUA 2ZSGA 4B28A 2BWWA 2GA2A 3MX6A 5CNXA 1N51A 2GU7A 2Q8KA 5JHUA 1YW9A 1QXYA 2GTXA 4S00A 4EGEA 3MATA 2EA4A 4U6ZA 3D27A 4IF7A 2BHDA 1C23A 1M35A 1YVMA 1MATA 3PKCA 4JUQA 4IPAA 1JAWA 1W7VA 1R5GA 4U73A 4FUKA 2MATA 4ZNGA 2P9AA 2Q93A 4QR8A 4HXXA 4PNCA 3MR1A 4S2RP 1WBQA 5CLSA 4U70A 4FKCA 4IDYA 2V3YA 4MATA 3BITA 2EA2A 2GGCA 4U6CA 2BWVA 1XNZA 2GU5A 1WL9A 2GG0A 3CB5A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2DFI A;  4IEC A;  4S01 A;  3TB5 A;  2Q96 A;  4A6W A;  4ZWU A;  3BIP A;  4U1B A;  3IU9 A;  2GGB A;  4OOK A;  2BN7 A;  4FO8 A;  2BHA A;  3FMR A;  1XGM A;  2BHB A;  1A16 A;  2G6P A;  2Q95 A;  4FO7 A;  5JFR A;  2B3H A;  2BB7 A;  5D6F A;  3CTZ A;  2EVM A;  3PKD A;  4IKS A;  4IKT A;  1C24 A;  1WY2 A;  2GG7 A;  4A6V A;  1R5H A;  5CE6 A;  1WL6 A;  3TAV A;  4Z7M A;  2P99 A;  4ZWO A;  4PV4 A;  3RVA A;  2BWU A;  2EVO A;  2GG9 A;  3L24 A;  4U6W A;  1BOA A;  3S6B A;  3CB6 A;  1PV9 A;  1O0X A;  4RGZ 1;  2IW2 A;  2HOW A;  2V3X A;  1KP0 A;  4KM3 A;  1XGS A;  2Q92 A;  4S2T P;  3IG4 A;  2GU6 A;  2OAZ A;  3BIQ A;  1WLR A;  2BWY A;  3PKA A;  2BH3 A;  4FLK A;  1WKM A;  5D6E A;  5JI6 A;  1WN1 A;  2NQ6 A;  5CIK A;  3L7G A;  4U6E A;  3PKE A;  3FMQ A;  3IU8 A;  3Q6D A;  1XGN A;  1C27 A;  1B6A A;  1KQ9 A;  1Y1N A;  2GU4 A;  2NQ7 A;  4R60 A;  1QZY A;  1C21 A;  1QXW A;  2GG5 A;  3PKB A;  4RZY A;  5E5B A;  4FLL A;  5CDE A;  5CDV A;  1BN5 A;  4U75 A;  2GG3 A;  2B3L A;  2V6C A;  1C22 A;  1KQ0 A;  4RZZ A;  4U71 A;  2ADU A;  1CHM A;  2B3K A;  2V3Z A;  4IU6 A;  5CDL A;  1YW8 A;  1R58 A;  2EVC A;  2Q94 A;  4ZWP A;  1YW7 A;  1W2M A;  3IU7 A;  4FLJ A;  3FM3 A;  2P98 A;  2BWS A;  1YJ3 A;  2GG2 A;  2BWX A;  2GG8 A;  4U76 A;  1B59 A;  1XGO A;  2OKN A;  2BHC A;  4FLI A;  2GZ5 A;  3ROR A;  4IKR A;  4U69 A;  5FCF A;  4U6J A;  1QXZ A;  5FCH A;  2BWT A;  4IKU A;  2ZSG A;  4B28 A;  2BWW A;  2GA2 A;  3MX6 A;  5CNX A;  1N51 A;  2GU7 A;  2Q8K A;  5JHU A;  1YW9 A;  1QXY A;  2GTX A;  4S00 A;  4EGE A;  3MAT A;  2EA4 A;  4U6Z A;  3D27 A;  4IF7 A;  2BHD A;  1C23 A;  1M35 A;  1YVM A;  1MAT A;  3PKC A;  4JUQ A;  4IPA A;  1JAW A;  1W7V A;  1R5G A;  4U73 A;  4FUK A;  2MAT A;  4ZNG A;  2P9A A;  2Q93 A;  4QR8 A;  4HXX A;  4PNC A;  3MR1 A;  4S2R P;  1WBQ A;  5CLS A;  4U70 A;  4FKC A;  4IDY A;  2V3Y A;  4MAT A;  3BIT A;  2EA2 A;  2GGC A;  4U6C A;  2BWV A;  1XNZ A;  2GU5 A;  1WL9 A;  2GG0 A;  3CB5 A; 
#chains in the Genus database with same CATH topology
 2DFI A;  4IEC A;  4S01 A;  3TB5 A;  2Q96 A;  4A6W A;  4ZWU A;  3BIP A;  4U1B A;  3IU9 A;  2GGB A;  4OOK A;  2BN7 A;  4FO8 A;  2BHA A;  3FMR A;  1XGM A;  2BHB A;  1A16 A;  2G6P A;  2Q95 A;  4FO7 A;  5JFR A;  2B3H A;  2BB7 A;  5D6F A;  3CTZ A;  2EVM A;  3PKD A;  4IKS A;  4IKT A;  1C24 A;  1WY2 A;  2GG7 A;  4A6V A;  1R5H A;  5CE6 A;  1WL6 A;  3TAV A;  4Z7M A;  2P99 A;  4ZWO A;  4PV4 A;  3RVA A;  2BWU A;  2EVO A;  2GG9 A;  3L24 A;  4U6W A;  1BOA A;  3S6B A;  3CB6 A;  1PV9 A;  1O0X A;  4RGZ 1;  2IW2 A;  2HOW A;  2V3X A;  1KP0 A;  4KM3 A;  1XGS A;  2Q92 A;  4S2T P;  3IG4 A;  2GU6 A;  2OAZ A;  3BIQ A;  1WLR A;  2BWY A;  3PKA A;  2BH3 A;  4FLK A;  1WKM A;  5D6E A;  5JI6 A;  1WN1 A;  2NQ6 A;  5CIK A;  3L7G A;  4U6E A;  3PKE A;  3FMQ A;  3IU8 A;  3Q6D A;  1XGN A;  1C27 A;  1B6A A;  1KQ9 A;  1Y1N A;  2GU4 A;  2NQ7 A;  4R60 A;  1QZY A;  1C21 A;  1QXW A;  2GG5 A;  3PKB A;  4RZY A;  5E5B A;  4FLL A;  5CDE A;  5CDV A;  1BN5 A;  4U75 A;  2GG3 A;  2B3L A;  2V6C A;  1C22 A;  1KQ0 A;  4RZZ A;  4U71 A;  2ADU A;  1CHM A;  2B3K A;  2V3Z A;  4IU6 A;  5CDL A;  1YW8 A;  1R58 A;  2EVC A;  2Q94 A;  4ZWP A;  1YW7 A;  1W2M A;  3IU7 A;  4FLJ A;  3FM3 A;  2P98 A;  2BWS A;  1YJ3 A;  2GG2 A;  2BWX A;  2GG8 A;  4U76 A;  1B59 A;  1XGO A;  2OKN A;  2BHC A;  4FLI A;  2GZ5 A;  3ROR A;  4IKR A;  4U69 A;  5FCF A;  4U6J A;  1QXZ A;  5FCH A;  2BWT A;  4IKU A;  2ZSG A;  4B28 A;  2BWW A;  2GA2 A;  3MX6 A;  5CNX A;  1N51 A;  2GU7 A;  2Q8K A;  5JHU A;  1YW9 A;  1QXY A;  2GTX A;  4S00 A;  4EGE A;  3MAT A;  2EA4 A;  4U6Z A;  3D27 A;  4IF7 A;  2BHD A;  1C23 A;  1M35 A;  1YVM A;  1MAT A;  3PKC A;  4JUQ A;  4IPA A;  1JAW A;  1W7V A;  1R5G A;  4U73 A;  4FUK A;  2MAT A;  4ZNG A;  2P9A A;  2Q93 A;  4QR8 A;  4HXX A;  4PNC A;  3MR1 A;  4S2R P;  1WBQ A;  5CLS A;  4U70 A;  4FKC A;  4IDY A;  2V3Y A;  4MAT A;  3BIT A;  2EA2 A;  2GGC A;  4U6C A;  2BWV A;  1XNZ A;  2GU5 A;  1WL9 A;  2GG0 A;  3CB5 A; 
#chains in the Genus database with same CATH homology
 2DFI A;  4IEC A;  4S01 A;  3TB5 A;  2Q96 A;  4A6W A;  4ZWU A;  3BIP A;  4U1B A;  3IU9 A;  2GGB A;  4OOK A;  2BN7 A;  4FO8 A;  2BHA A;  3FMR A;  1XGM A;  2BHB A;  1A16 A;  2G6P A;  2Q95 A;  4FO7 A;  5JFR A;  2B3H A;  2BB7 A;  5D6F A;  3CTZ A;  2EVM A;  3PKD A;  4IKS A;  4IKT A;  1C24 A;  1WY2 A;  2GG7 A;  4A6V A;  1R5H A;  5CE6 A;  1WL6 A;  3TAV A;  4Z7M A;  2P99 A;  4ZWO A;  4PV4 A;  3RVA A;  2BWU A;  2EVO A;  2GG9 A;  3L24 A;  4U6W A;  1BOA A;  3S6B A;  3CB6 A;  1PV9 A;  1O0X A;  4RGZ 1;  2IW2 A;  2HOW A;  2V3X A;  1KP0 A;  4KM3 A;  1XGS A;  2Q92 A;  4S2T P;  3IG4 A;  2GU6 A;  2OAZ A;  3BIQ A;  1WLR A;  2BWY A;  3PKA A;  2BH3 A;  4FLK A;  1WKM A;  5D6E A;  5JI6 A;  1WN1 A;  2NQ6 A;  5CIK A;  3L7G A;  4U6E A;  3PKE A;  3FMQ A;  3IU8 A;  3Q6D A;  1XGN A;  1C27 A;  1B6A A;  1KQ9 A;  1Y1N A;  2GU4 A;  2NQ7 A;  4R60 A;  1QZY A;  1C21 A;  1QXW A;  2GG5 A;  3PKB A;  4RZY A;  5E5B A;  4FLL A;  5CDE A;  5CDV A;  1BN5 A;  4U75 A;  2GG3 A;  2B3L A;  2V6C A;  1C22 A;  1KQ0 A;  4RZZ A;  4U71 A;  2ADU A;  1CHM A;  2B3K A;  2V3Z A;  4IU6 A;  5CDL A;  1YW8 A;  1R58 A;  2EVC A;  2Q94 A;  4ZWP A;  1YW7 A;  1W2M A;  3IU7 A;  4FLJ A;  3FM3 A;  2P98 A;  2BWS A;  1YJ3 A;  2GG2 A;  2BWX A;  2GG8 A;  4U76 A;  1B59 A;  1XGO A;  2OKN A;  2BHC A;  4FLI A;  2GZ5 A;  3ROR A;  4IKR A;  4U69 A;  5FCF A;  4U6J A;  1QXZ A;  5FCH A;  2BWT A;  4IKU A;  2ZSG A;  4B28 A;  2BWW A;  2GA2 A;  3MX6 A;  5CNX A;  1N51 A;  2GU7 A;  2Q8K A;  5JHU A;  1YW9 A;  1QXY A;  2GTX A;  4S00 A;  4EGE A;  3MAT A;  2EA4 A;  4U6Z A;  3D27 A;  4IF7 A;  2BHD A;  1C23 A;  1M35 A;  1YVM A;  1MAT A;  3PKC A;  4JUQ A;  4IPA A;  1JAW A;  1W7V A;  1R5G A;  4U73 A;  4FUK A;  2MAT A;  4ZNG A;  2P9A A;  2Q93 A;  4QR8 A;  4HXX A;  4PNC A;  3MR1 A;  4S2R P;  1WBQ A;  5CLS A;  4U70 A;  4FKC A;  4IDY A;  2V3Y A;  4MAT A;  3BIT A;  2EA2 A;  2GGC A;  4U6C A;  2BWV A;  1XNZ A;  2GU5 A;  1WL9 A;  2GG0 A;  3CB5 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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