4IKRA

Crystal structure of type 1 human methionine aminopeptidase in complex with 2-(4-(5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)piperazin-1-yl)ethanol
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-12-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ikrA00
4U71A 1KP0A 1QXZA 4IDYA 1YVMA 1C27A 2BHBA 2Q8KA 2BN7A 1YW7A 4IECA 2Q93A 4S2RP 1N51A 2GA2A 2GZ5A 1KQ9A 1WKMA 5CNXA 3PKCA 4U6EA 3PKBA 1XGNA 4U6CA 3D27A 5D6EA 4MATA 4U69A 4IKRA 1M35A 3IU7A 4OOKA 1WLRA 2GGCA 1W7VA 3IU8A 2OKNA 4A6WA 1YW8A 2B3KA 5JFRA 4RZZA 2BB7A 4PV4A 3BIPA 5CDVA 1R58A 2EVCA 4IF7A 1C23A 1C24A 1WL9A 4U6ZA 4ZNGA 4S2TP 1QXWA 1JAWA 1C21A 1XNZA 2GG5A 2V6CA 3L24A 4U6WA 2GTXA 2BHAA 3Q6DA 2GG8A 4U1BA 2Q94A 5JI6A 5CIKA 2HOWA 4U6JA 2ZSGA 4QR8A 1WL6A 2GU6A 1QXYA 4EGEA 5CE6A 4FO8A 1MATA 2IW2A 2G6PA 3PKDA 1R5HA 2BWSA 1C22A 2BWUA 2GGBA 3L7GA 3TB5A 1BN5A 2EA2A 4IKUA 3BIQA 2GG3A 2OAZA 3TAVA 2P99A 2BHDA 4FLJA 2EVMA 2GG9A 2DFIA 5CLSA 3FM3A 3CB5A 2GG2A 2BWWA 1B59A 1KQ0A 4ZWPA 3FMRA 4U75A 3RVAA 1XGMA 4FKCA 5CDEA 4R60A 2V3YA 2P9AA 3MX6A 3RORA 4U73A 1QZYA 4FLLA 2B3LA 1R5GA 2GU5A 4S01A 2EVOA 2ADUA 3PKAA 1W2MA 2Q95A 2P98A 1XGOA 5E5BA 4ZWUA 5FCFA 2BWVA 4RZYA 1PV9A 3S6BA 1YJ3A 4Z7MA 1WY2A 2MATA 4JUQA 1WN1A 3IG4A 2Q92A 4FUKA 3MR1A 4PNCA 4KM3A 4IKSA 4IPAA 3BITA 2GU4A 5CDLA 2Q96A 2BH3A 3CB6A 2GG7A 4FLKA 5D6FA 4U76A 4RGZ1 1WBQA 2BWTA 3FMQA 5FCHA 4IKTA 4FLIA 5JHUA 1B6AA 2V3ZA 3PKEA 4FO7A 1XGSA 2GU7A 1YW9A 1BOAA 4ZWOA 1O0XA 2BWXA 2NQ6A 3MATA 2BWYA 2NQ7A 3IU9A 2V3XA 1A16A 2EA4A 2B3HA 1CHMA 4S00A 3CTZA 4IU6A 4U70A 1Y1NA 4B28A 2BHCA 4A6VA 2GG0A 4HXXA
chains in the Genus database with same CATH superfamily
4U71A 1KP0A 1QXZA 4IDYA 1YVMA 1C27A 2BHBA 2Q8KA 2BN7A 1YW7A 4IECA 2Q93A 4S2RP 1N51A 2GA2A 2GZ5A 1KQ9A 1WKMA 5CNXA 3PKCA 4U6EA 3PKBA 1XGNA 4U6CA 3D27A 5D6EA 4MATA 4U69A 4IKRA 1M35A 3IU7A 4OOKA 1WLRA 2GGCA 1W7VA 3IU8A 2OKNA 4A6WA 1YW8A 2B3KA 5JFRA 4RZZA 2BB7A 4PV4A 3BIPA 5CDVA 1R58A 2EVCA 4IF7A 1C23A 1C24A 1WL9A 4U6ZA 4ZNGA 4S2TP 1QXWA 1JAWA 1C21A 1XNZA 2GG5A 2V6CA 3L24A 4U6WA 2GTXA 2BHAA 3Q6DA 2GG8A 4U1BA 2Q94A 5JI6A 5CIKA 2HOWA 4U6JA 2ZSGA 4QR8A 1WL6A 2GU6A 1QXYA 4EGEA 5CE6A 4FO8A 1MATA 2IW2A 2G6PA 3PKDA 1R5HA 2BWSA 1C22A 2BWUA 2GGBA 3L7GA 3TB5A 1BN5A 2EA2A 4IKUA 3BIQA 2GG3A 2OAZA 3TAVA 2P99A 2BHDA 4FLJA 2EVMA 2GG9A 2DFIA 5CLSA 3FM3A 3CB5A 2GG2A 2BWWA 1B59A 1KQ0A 4ZWPA 3FMRA 4U75A 3RVAA 1XGMA 4FKCA 5CDEA 4R60A 2V3YA 2P9AA 3MX6A 3RORA 4U73A 1QZYA 4FLLA 2B3LA 1R5GA 2GU5A 4S01A 2EVOA 2ADUA 3PKAA 1W2MA 2Q95A 2P98A 1XGOA 5E5BA 4ZWUA 5FCFA 2BWVA 4RZYA 1PV9A 3S6BA 1YJ3A 4Z7MA 1WY2A 2MATA 4JUQA 1WN1A 3IG4A 2Q92A 4FUKA 3MR1A 4PNCA 4KM3A 4IKSA 4IPAA 3BITA 2GU4A 5CDLA 2Q96A 2BH3A 3CB6A 2GG7A 4FLKA 5D6FA 4U76A 4RGZ1 1WBQA 2BWTA 3FMQA 5FCHA 4IKTA 4FLIA 5JHUA 1B6AA 2V3ZA 3PKEA 4FO7A 1XGSA 2GU7A 1YW9A 1BOAA 4ZWOA 1O0XA 2BWXA 2NQ6A 3MATA 2BWYA 2NQ7A 3IU9A 2V3XA 1A16A 2EA4A 2B3HA 1CHMA 4S00A 3CTZA 4IU6A 4U70A 1Y1NA 4B28A 2BHCA 4A6VA 2GG0A 4HXXA
chains in the Genus database with same CATH topology
4U71A 1KP0A 1QXZA 4IDYA 1YVMA 1C27A 2BHBA 2Q8KA 2BN7A 1YW7A 4IECA 2Q93A 4S2RP 1N51A 2GA2A 2GZ5A 1KQ9A 1WKMA 5CNXA 3PKCA 4U6EA 3PKBA 1XGNA 4U6CA 3D27A 5D6EA 4MATA 4U69A 4IKRA 1M35A 3IU7A 4OOKA 1WLRA 2GGCA 1W7VA 3IU8A 2OKNA 4A6WA 1YW8A 2B3KA 5JFRA 4RZZA 2BB7A 4PV4A 3BIPA 5CDVA 1R58A 2EVCA 4IF7A 1C23A 1C24A 1WL9A 4U6ZA 4ZNGA 4S2TP 1QXWA 1JAWA 1C21A 1XNZA 2GG5A 2V6CA 3L24A 4U6WA 2GTXA 2BHAA 3Q6DA 2GG8A 4U1BA 2Q94A 5JI6A 5CIKA 2HOWA 4U6JA 2ZSGA 4QR8A 1WL6A 2GU6A 1QXYA 4EGEA 5CE6A 4FO8A 1MATA 2IW2A 2G6PA 3PKDA 1R5HA 2BWSA 1C22A 2BWUA 2GGBA 3L7GA 3TB5A 1BN5A 2EA2A 4IKUA 3BIQA 2GG3A 2OAZA 3TAVA 2P99A 2BHDA 4FLJA 2EVMA 2GG9A 2DFIA 5CLSA 3FM3A 3CB5A 2GG2A 2BWWA 1B59A 1KQ0A 4ZWPA 3FMRA 4U75A 3RVAA 1XGMA 4FKCA 5CDEA 4R60A 2V3YA 2P9AA 3MX6A 3RORA 4U73A 1QZYA 4FLLA 2B3LA 1R5GA 2GU5A 4S01A 2EVOA 2ADUA 3PKAA 1W2MA 2Q95A 2P98A 1XGOA 5E5BA 4ZWUA 5FCFA 2BWVA 4RZYA 1PV9A 3S6BA 1YJ3A 4Z7MA 1WY2A 2MATA 4JUQA 1WN1A 3IG4A 2Q92A 4FUKA 3MR1A 4PNCA 4KM3A 4IKSA 4IPAA 3BITA 2GU4A 5CDLA 2Q96A 2BH3A 3CB6A 2GG7A 4FLKA 5D6FA 4U76A 4RGZ1 1WBQA 2BWTA 3FMQA 5FCHA 4IKTA 4FLIA 5JHUA 1B6AA 2V3ZA 3PKEA 4FO7A 1XGSA 2GU7A 1YW9A 1BOAA 4ZWOA 1O0XA 2BWXA 2NQ6A 3MATA 2BWYA 2NQ7A 3IU9A 2V3XA 1A16A 2EA4A 2B3HA 1CHMA 4S00A 3CTZA 4IU6A 4U70A 1Y1NA 4B28A 2BHCA 4A6VA 2GG0A 4HXXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U71 A;  1KP0 A;  1QXZ A;  4IDY A;  1YVM A;  1C27 A;  2BHB A;  2Q8K A;  2BN7 A;  1YW7 A;  4IEC A;  2Q93 A;  4S2R P;  1N51 A;  2GA2 A;  2GZ5 A;  1KQ9 A;  1WKM A;  5CNX A;  3PKC A;  4U6E A;  3PKB A;  1XGN A;  4U6C A;  3D27 A;  5D6E A;  4MAT A;  4U69 A;  4IKR A;  1M35 A;  3IU7 A;  4OOK A;  1WLR A;  2GGC A;  1W7V A;  3IU8 A;  2OKN A;  4A6W A;  1YW8 A;  2B3K A;  5JFR A;  4RZZ A;  2BB7 A;  4PV4 A;  3BIP A;  5CDV A;  1R58 A;  2EVC A;  4IF7 A;  1C23 A;  1C24 A;  1WL9 A;  4U6Z A;  4ZNG A;  4S2T P;  1QXW A;  1JAW A;  1C21 A;  1XNZ A;  2GG5 A;  2V6C A;  3L24 A;  4U6W A;  2GTX A;  2BHA A;  3Q6D A;  2GG8 A;  4U1B A;  2Q94 A;  5JI6 A;  5CIK A;  2HOW A;  4U6J A;  2ZSG A;  4QR8 A;  1WL6 A;  2GU6 A;  1QXY A;  4EGE A;  5CE6 A;  4FO8 A;  1MAT A;  2IW2 A;  2G6P A;  3PKD A;  1R5H A;  2BWS A;  1C22 A;  2BWU A;  2GGB A;  3L7G A;  3TB5 A;  1BN5 A;  2EA2 A;  4IKU A;  3BIQ A;  2GG3 A;  2OAZ A;  3TAV A;  2P99 A;  2BHD A;  4FLJ A;  2EVM A;  2GG9 A;  2DFI A;  5CLS A;  3FM3 A;  3CB5 A;  2GG2 A;  2BWW A;  1B59 A;  1KQ0 A;  4ZWP A;  3FMR A;  4U75 A;  3RVA A;  1XGM A;  4FKC A;  5CDE A;  4R60 A;  2V3Y A;  2P9A A;  3MX6 A;  3ROR A;  4U73 A;  1QZY A;  4FLL A;  2B3L A;  1R5G A;  2GU5 A;  4S01 A;  2EVO A;  2ADU A;  3PKA A;  1W2M A;  2Q95 A;  2P98 A;  1XGO A;  5E5B A;  4ZWU A;  5FCF A;  2BWV A;  4RZY A;  1PV9 A;  3S6B A;  1YJ3 A;  4Z7M A;  1WY2 A;  2MAT A;  4JUQ A;  1WN1 A;  3IG4 A;  2Q92 A;  4FUK A;  3MR1 A;  4PNC A;  4KM3 A;  4IKS A;  4IPA A;  3BIT A;  2GU4 A;  5CDL A;  2Q96 A;  2BH3 A;  3CB6 A;  2GG7 A;  4FLK A;  5D6F A;  4U76 A;  4RGZ 1;  1WBQ A;  2BWT A;  3FMQ A;  5FCH A;  4IKT A;  4FLI A;  5JHU A;  1B6A A;  2V3Z A;  3PKE A;  4FO7 A;  1XGS A;  2GU7 A;  1YW9 A;  1BOA A;  4ZWO A;  1O0X A;  2BWX A;  2NQ6 A;  3MAT A;  2BWY A;  2NQ7 A;  3IU9 A;  2V3X A;  1A16 A;  2EA4 A;  2B3H A;  1CHM A;  4S00 A;  3CTZ A;  4IU6 A;  4U70 A;  1Y1N A;  4B28 A;  2BHC A;  4A6V A;  2GG0 A;  4HXX A; 
#chains in the Genus database with same CATH topology
 4U71 A;  1KP0 A;  1QXZ A;  4IDY A;  1YVM A;  1C27 A;  2BHB A;  2Q8K A;  2BN7 A;  1YW7 A;  4IEC A;  2Q93 A;  4S2R P;  1N51 A;  2GA2 A;  2GZ5 A;  1KQ9 A;  1WKM A;  5CNX A;  3PKC A;  4U6E A;  3PKB A;  1XGN A;  4U6C A;  3D27 A;  5D6E A;  4MAT A;  4U69 A;  4IKR A;  1M35 A;  3IU7 A;  4OOK A;  1WLR A;  2GGC A;  1W7V A;  3IU8 A;  2OKN A;  4A6W A;  1YW8 A;  2B3K A;  5JFR A;  4RZZ A;  2BB7 A;  4PV4 A;  3BIP A;  5CDV A;  1R58 A;  2EVC A;  4IF7 A;  1C23 A;  1C24 A;  1WL9 A;  4U6Z A;  4ZNG A;  4S2T P;  1QXW A;  1JAW A;  1C21 A;  1XNZ A;  2GG5 A;  2V6C A;  3L24 A;  4U6W A;  2GTX A;  2BHA A;  3Q6D A;  2GG8 A;  4U1B A;  2Q94 A;  5JI6 A;  5CIK A;  2HOW A;  4U6J A;  2ZSG A;  4QR8 A;  1WL6 A;  2GU6 A;  1QXY A;  4EGE A;  5CE6 A;  4FO8 A;  1MAT A;  2IW2 A;  2G6P A;  3PKD A;  1R5H A;  2BWS A;  1C22 A;  2BWU A;  2GGB A;  3L7G A;  3TB5 A;  1BN5 A;  2EA2 A;  4IKU A;  3BIQ A;  2GG3 A;  2OAZ A;  3TAV A;  2P99 A;  2BHD A;  4FLJ A;  2EVM A;  2GG9 A;  2DFI A;  5CLS A;  3FM3 A;  3CB5 A;  2GG2 A;  2BWW A;  1B59 A;  1KQ0 A;  4ZWP A;  3FMR A;  4U75 A;  3RVA A;  1XGM A;  4FKC A;  5CDE A;  4R60 A;  2V3Y A;  2P9A A;  3MX6 A;  3ROR A;  4U73 A;  1QZY A;  4FLL A;  2B3L A;  1R5G A;  2GU5 A;  4S01 A;  2EVO A;  2ADU A;  3PKA A;  1W2M A;  2Q95 A;  2P98 A;  1XGO A;  5E5B A;  4ZWU A;  5FCF A;  2BWV A;  4RZY A;  1PV9 A;  3S6B A;  1YJ3 A;  4Z7M A;  1WY2 A;  2MAT A;  4JUQ A;  1WN1 A;  3IG4 A;  2Q92 A;  4FUK A;  3MR1 A;  4PNC A;  4KM3 A;  4IKS A;  4IPA A;  3BIT A;  2GU4 A;  5CDL A;  2Q96 A;  2BH3 A;  3CB6 A;  2GG7 A;  4FLK A;  5D6F A;  4U76 A;  4RGZ 1;  1WBQ A;  2BWT A;  3FMQ A;  5FCH A;  4IKT A;  4FLI A;  5JHU A;  1B6A A;  2V3Z A;  3PKE A;  4FO7 A;  1XGS A;  2GU7 A;  1YW9 A;  1BOA A;  4ZWO A;  1O0X A;  2BWX A;  2NQ6 A;  3MAT A;  2BWY A;  2NQ7 A;  3IU9 A;  2V3X A;  1A16 A;  2EA4 A;  2B3H A;  1CHM A;  4S00 A;  3CTZ A;  4IU6 A;  4U70 A;  1Y1N A;  4B28 A;  2BHC A;  4A6V A;  2GG0 A;  4HXX A; 
#chains in the Genus database with same CATH homology
 4U71 A;  1KP0 A;  1QXZ A;  4IDY A;  1YVM A;  1C27 A;  2BHB A;  2Q8K A;  2BN7 A;  1YW7 A;  4IEC A;  2Q93 A;  4S2R P;  1N51 A;  2GA2 A;  2GZ5 A;  1KQ9 A;  1WKM A;  5CNX A;  3PKC A;  4U6E A;  3PKB A;  1XGN A;  4U6C A;  3D27 A;  5D6E A;  4MAT A;  4U69 A;  4IKR A;  1M35 A;  3IU7 A;  4OOK A;  1WLR A;  2GGC A;  1W7V A;  3IU8 A;  2OKN A;  4A6W A;  1YW8 A;  2B3K A;  5JFR A;  4RZZ A;  2BB7 A;  4PV4 A;  3BIP A;  5CDV A;  1R58 A;  2EVC A;  4IF7 A;  1C23 A;  1C24 A;  1WL9 A;  4U6Z A;  4ZNG A;  4S2T P;  1QXW A;  1JAW A;  1C21 A;  1XNZ A;  2GG5 A;  2V6C A;  3L24 A;  4U6W A;  2GTX A;  2BHA A;  3Q6D A;  2GG8 A;  4U1B A;  2Q94 A;  5JI6 A;  5CIK A;  2HOW A;  4U6J A;  2ZSG A;  4QR8 A;  1WL6 A;  2GU6 A;  1QXY A;  4EGE A;  5CE6 A;  4FO8 A;  1MAT A;  2IW2 A;  2G6P A;  3PKD A;  1R5H A;  2BWS A;  1C22 A;  2BWU A;  2GGB A;  3L7G A;  3TB5 A;  1BN5 A;  2EA2 A;  4IKU A;  3BIQ A;  2GG3 A;  2OAZ A;  3TAV A;  2P99 A;  2BHD A;  4FLJ A;  2EVM A;  2GG9 A;  2DFI A;  5CLS A;  3FM3 A;  3CB5 A;  2GG2 A;  2BWW A;  1B59 A;  1KQ0 A;  4ZWP A;  3FMR A;  4U75 A;  3RVA A;  1XGM A;  4FKC A;  5CDE A;  4R60 A;  2V3Y A;  2P9A A;  3MX6 A;  3ROR A;  4U73 A;  1QZY A;  4FLL A;  2B3L A;  1R5G A;  2GU5 A;  4S01 A;  2EVO A;  2ADU A;  3PKA A;  1W2M A;  2Q95 A;  2P98 A;  1XGO A;  5E5B A;  4ZWU A;  5FCF A;  2BWV A;  4RZY A;  1PV9 A;  3S6B A;  1YJ3 A;  4Z7M A;  1WY2 A;  2MAT A;  4JUQ A;  1WN1 A;  3IG4 A;  2Q92 A;  4FUK A;  3MR1 A;  4PNC A;  4KM3 A;  4IKS A;  4IPA A;  3BIT A;  2GU4 A;  5CDL A;  2Q96 A;  2BH3 A;  3CB6 A;  2GG7 A;  4FLK A;  5D6F A;  4U76 A;  4RGZ 1;  1WBQ A;  2BWT A;  3FMQ A;  5FCH A;  4IKT A;  4FLI A;  5JHU A;  1B6A A;  2V3Z A;  3PKE A;  4FO7 A;  1XGS A;  2GU7 A;  1YW9 A;  1BOA A;  4ZWO A;  1O0X A;  2BWX A;  2NQ6 A;  3MAT A;  2BWY A;  2NQ7 A;  3IU9 A;  2V3X A;  1A16 A;  2EA4 A;  2B3H A;  1CHM A;  4S00 A;  3CTZ A;  4IU6 A;  4U70 A;  1Y1N A;  4B28 A;  2BHC A;  4A6V A;  2GG0 A;  4HXX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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