The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
99
|
sequence length |
304
|
structure length |
304
|
Chain Sequence |
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.
pubmed doi rcsb |
| molecule tags |
Hydrolase/hydrolase inhibitor
|
| source organism |
Homo sapiens
|
| molecule keywords |
Methionine aminopeptidase 1
|
| total genus |
99
|
| structure length |
304
|
| sequence length |
304
|
| ec nomenclature |
ec
3.4.11.18: Methionyl aminopeptidase. |
| pdb deposition date | 2013-01-19 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00557 | Peptidase_M24 | Metallopeptidase family M24 |
| A | PF15801 | zf-C6H2 | zf-MYND-like zinc finger, mRNA-binding |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Alpha-Beta Complex | Creatine Amidinohydrolase | Creatinase/methionine aminopeptidase superfamily |
#chains in the Genus database with same CATH superfamily 2BWY A; 2BN7 A; 4FKC A; 4ZWO A; 5CLS A; 4ZNG A; 2Q96 A; 3PKD A; 3IU7 A; 1QXY A; 3CB6 A; 1BOA A; 1R5H A; 2MAT A; 2HOW A; 1PV9 A; 4FLI A; 4IKT A; 4RZZ A; 2Q8K A; 1C21 A; 2GG2 A; 4FUK A; 2BWX A; 4U1B A; 1A16 A; 4S2T P; 1BN5 A; 4RZY A; 2BHA A; 3FMR A; 4ZWP A; 4U71 A; 5FCF A; 1KP0 A; 3ROR A; 3PKA A; 3MX6 A; 5CDL A; 1Y1N A; 5D6F A; 1YW9 A; 2GGC A; 4FO8 A; 2OAZ A; 1XGN A; 2GG5 A; 1YW8 A; 4IKS A; 1JAW A; 1CHM A; 3BIP A; 2GTX A; 3L7G A; 5CDE A; 1C22 A; 3BIT A; 4IKR A; 4U6Z A; 2EVO A; 4FLL A; 4PV4 A; 3IU9 A; 5E5B A; 1WBQ A; 1WL9 A; 2BWT A; 2Q93 A; 3IG4 A; 2GU4 A; 3D27 A; 2V3Z A; 2GU7 A; 2Q92 A; 2DFI A; 3TAV A; 4R60 A; 3PKB A; 1YVM A; 1YW7 A; 2GU6 A; 2Q94 A; 2B3L A; 4A6W A; 4U6E A; 1QXW A; 2V3Y A; 3MAT A; 1KQ9 A; 1MAT A; 1XGM A; 3IU8 A; 3MR1 A; 4KM3 A; 3BIQ A; 4EGE A; 2BHD A; 1YJ3 A; 2BWV A; 4IKU A; 2ZSG A; 4U6W A; 2EVM A; 5D6E A; 4Z7M A; 2GG8 A; 2V6C A; 4PNC A; 2BB7 A; 3L24 A; 1WKM A; 1R58 A; 2B3H A; 4IF7 A; 2GGB A; 2ADU A; 2V3X A; 4FO7 A; 1XGS A; 4U6J A; 5JHU A; 4HXX A; 1XNZ A; 2Q95 A; 2B3K A; 1QXZ A; 4JUQ A; 3FM3 A; 4U75 A; 5JFR A; 1WL6 A; 2GZ5 A; 4B28 A; 4U76 A; 4MAT A; 1N51 A; 4FLJ A; 2IW2 A; 3Q6D A; 4A6V A; 1W2M A; 3CTZ A; 3PKE A; 4RGZ 1; 1M35 A; 1C27 A; 1B59 A; 2NQ7 A; 4S2R P; 1XGO A; 4IPA A; 4S01 A; 4U73 A; 2GA2 A; 4U70 A; 5CDV A; 1QZY A; 4U69 A; 2NQ6 A; 5FCH A; 5JI6 A; 2GG7 A; 2OKN A; 2GG0 A; 1C24 A; 2EVC A; 4ZWU A; 1WY2 A; 1WLR A; 4IDY A; 2G6P A; 2EA4 A; 2BH3 A; 5CNX A; 1R5G A; 1O0X A; 2EA2 A; 2P9A A; 3FMQ A; 4S00 A; 2P98 A; 3CB5 A; 2GU5 A; 2BWS A; 2BWW A; 2BHB A; 2GG3 A; 3RVA A; 1WN1 A; 2P99 A; 3PKC A; 2BWU A; 4OOK A; 1C23 A; 3S6B A; 4U6C A; 5CIK A; 1KQ0 A; 1B6A A; 2GG9 A; 4IEC A; 4IU6 A; 4QR8 A; 1W7V A; 5CE6 A; 3TB5 A; 4FLK A; 2BHC A; #chains in the Genus database with same CATH topology 2BWY A; 2BN7 A; 4FKC A; 4ZWO A; 5CLS A; 4ZNG A; 2Q96 A; 3PKD A; 3IU7 A; 1QXY A; 3CB6 A; 1BOA A; 1R5H A; 2MAT A; 2HOW A; 1PV9 A; 4FLI A; 4IKT A; 4RZZ A; 2Q8K A; 1C21 A; 2GG2 A; 4FUK A; 2BWX A; 4U1B A; 1A16 A; 4S2T P; 1BN5 A; 4RZY A; 2BHA A; 3FMR A; 4ZWP A; 4U71 A; 5FCF A; 1KP0 A; 3ROR A; 3PKA A; 3MX6 A; 5CDL A; 1Y1N A; 5D6F A; 1YW9 A; 2GGC A; 4FO8 A; 2OAZ A; 1XGN A; 2GG5 A; 1YW8 A; 4IKS A; 1JAW A; 1CHM A; 3BIP A; 2GTX A; 3L7G A; 5CDE A; 1C22 A; 3BIT A; 4IKR A; 4U6Z A; 2EVO A; 4FLL A; 4PV4 A; 3IU9 A; 5E5B A; 1WBQ A; 1WL9 A; 2BWT A; 2Q93 A; 3IG4 A; 2GU4 A; 3D27 A; 2V3Z A; 2GU7 A; 2Q92 A; 2DFI A; 3TAV A; 4R60 A; 3PKB A; 1YVM A; 1YW7 A; 2GU6 A; 2Q94 A; 2B3L A; 4A6W A; 4U6E A; 1QXW A; 2V3Y A; 3MAT A; 1KQ9 A; 1MAT A; 1XGM A; 3IU8 A; 3MR1 A; 4KM3 A; 3BIQ A; 4EGE A; 2BHD A; 1YJ3 A; 2BWV A; 4IKU A; 2ZSG A; 4U6W A; 2EVM A; 5D6E A; 4Z7M A; 2GG8 A; 2V6C A; 4PNC A; 2BB7 A; 3L24 A; 1WKM A; 1R58 A; 2B3H A; 4IF7 A; 2GGB A; 2ADU A; 2V3X A; 4FO7 A; 1XGS A; 4U6J A; 5JHU A; 4HXX A; 1XNZ A; 2Q95 A; 2B3K A; 1QXZ A; 4JUQ A; 3FM3 A; 4U75 A; 5JFR A; 1WL6 A; 2GZ5 A; 4B28 A; 4U76 A; 4MAT A; 1N51 A; 4FLJ A; 2IW2 A; 3Q6D A; 4A6V A; 1W2M A; 3CTZ A; 3PKE A; 4RGZ 1; 1M35 A; 1C27 A; 1B59 A; 2NQ7 A; 4S2R P; 1XGO A; 4IPA A; 4S01 A; 4U73 A; 2GA2 A; 4U70 A; 5CDV A; 1QZY A; 4U69 A; 2NQ6 A; 5FCH A; 5JI6 A; 2GG7 A; 2OKN A; 2GG0 A; 1C24 A; 2EVC A; 4ZWU A; 1WY2 A; 1WLR A; 4IDY A; 2G6P A; 2EA4 A; 2BH3 A; 5CNX A; 1R5G A; 1O0X A; 2EA2 A; 2P9A A; 3FMQ A; 4S00 A; 2P98 A; 3CB5 A; 2GU5 A; 2BWS A; 2BWW A; 2BHB A; 2GG3 A; 3RVA A; 1WN1 A; 2P99 A; 3PKC A; 2BWU A; 4OOK A; 1C23 A; 3S6B A; 4U6C A; 5CIK A; 1KQ0 A; 1B6A A; 2GG9 A; 4IEC A; 4IU6 A; 4QR8 A; 1W7V A; 5CE6 A; 3TB5 A; 4FLK A; 2BHC A; #chains in the Genus database with same CATH homology 2BWY A; 2BN7 A; 4FKC A; 4ZWO A; 5CLS A; 4ZNG A; 2Q96 A; 3PKD A; 3IU7 A; 1QXY A; 3CB6 A; 1BOA A; 1R5H A; 2MAT A; 2HOW A; 1PV9 A; 4FLI A; 4IKT A; 4RZZ A; 2Q8K A; 1C21 A; 2GG2 A; 4FUK A; 2BWX A; 4U1B A; 1A16 A; 4S2T P; 1BN5 A; 4RZY A; 2BHA A; 3FMR A; 4ZWP A; 4U71 A; 5FCF A; 1KP0 A; 3ROR A; 3PKA A; 3MX6 A; 5CDL A; 1Y1N A; 5D6F A; 1YW9 A; 2GGC A; 4FO8 A; 2OAZ A; 1XGN A; 2GG5 A; 1YW8 A; 4IKS A; 1JAW A; 1CHM A; 3BIP A; 2GTX A; 3L7G A; 5CDE A; 1C22 A; 3BIT A; 4IKR A; 4U6Z A; 2EVO A; 4FLL A; 4PV4 A; 3IU9 A; 5E5B A; 1WBQ A; 1WL9 A; 2BWT A; 2Q93 A; 3IG4 A; 2GU4 A; 3D27 A; 2V3Z A; 2GU7 A; 2Q92 A; 2DFI A; 3TAV A; 4R60 A; 3PKB A; 1YVM A; 1YW7 A; 2GU6 A; 2Q94 A; 2B3L A; 4A6W A; 4U6E A; 1QXW A; 2V3Y A; 3MAT A; 1KQ9 A; 1MAT A; 1XGM A; 3IU8 A; 3MR1 A; 4KM3 A; 3BIQ A; 4EGE A; 2BHD A; 1YJ3 A; 2BWV A; 4IKU A; 2ZSG A; 4U6W A; 2EVM A; 5D6E A; 4Z7M A; 2GG8 A; 2V6C A; 4PNC A; 2BB7 A; 3L24 A; 1WKM A; 1R58 A; 2B3H A; 4IF7 A; 2GGB A; 2ADU A; 2V3X A; 4FO7 A; 1XGS A; 4U6J A; 5JHU A; 4HXX A; 1XNZ A; 2Q95 A; 2B3K A; 1QXZ A; 4JUQ A; 3FM3 A; 4U75 A; 5JFR A; 1WL6 A; 2GZ5 A; 4B28 A; 4U76 A; 4MAT A; 1N51 A; 4FLJ A; 2IW2 A; 3Q6D A; 4A6V A; 1W2M A; 3CTZ A; 3PKE A; 4RGZ 1; 1M35 A; 1C27 A; 1B59 A; 2NQ7 A; 4S2R P; 1XGO A; 4IPA A; 4S01 A; 4U73 A; 2GA2 A; 4U70 A; 5CDV A; 1QZY A; 4U69 A; 2NQ6 A; 5FCH A; 5JI6 A; 2GG7 A; 2OKN A; 2GG0 A; 1C24 A; 2EVC A; 4ZWU A; 1WY2 A; 1WLR A; 4IDY A; 2G6P A; 2EA4 A; 2BH3 A; 5CNX A; 1R5G A; 1O0X A; 2EA2 A; 2P9A A; 3FMQ A; 4S00 A; 2P98 A; 3CB5 A; 2GU5 A; 2BWS A; 2BWW A; 2BHB A; 2GG3 A; 3RVA A; 1WN1 A; 2P99 A; 3PKC A; 2BWU A; 4OOK A; 1C23 A; 3S6B A; 4U6C A; 5CIK A; 1KQ0 A; 1B6A A; 2GG9 A; 4IEC A; 4IU6 A; 4QR8 A; 1W7V A; 5CE6 A; 3TB5 A; 4FLK A; 2BHC A;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
