4KM3A

Discovery of a novel structural motif in methionine aminopeptidase from streptococci with possible post-translational modification
Total Genus 72
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
72
sequence length
286
structure length
286
Chain Sequence
MITLKSAREIEAMDKAGDFLASIHIGLRDLIKPGVDMWEVEEYVRRRCKEENFLPLQIGVDGAMMDYPYATCCSLNDEVAHAFPRHYILKDGDLLKVDMVLGGPIAKSDLNVSKLNFNNVEQMKKYTQSYSGGLADSCWAYAVGTPSEEVKNLMDITKEAMYKGIEQAVVGNRIGDIGAAIQEYAESRGYGVVRDLVGHGVGPTMHEEPMVPNYGIAGRGLRLREGMVLTIEPMINTGDWEIDTDMKTGWAHKTIDGGLSCQYEHQFVITKDGPVILTSQGEEGTY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery of a new genetic variant of methionine aminopeptidase from streptococci with possible post-translational modifications: biochemical and structural characterization.
pubmed doi rcsb
molecule tags Hydrolase
source organism Streptococcus pneumoniae
molecule keywords Methionine aminopeptidase
total genus 72
structure length 286
sequence length 286
chains with identical sequence B
ec nomenclature
pdb deposition date 2013-05-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4km3A00
4U6ZA 4R60A 2GTXA 1C22A 2BWSA 2EVCA 4FUKA 4RZYA 4KM3A 3FM3A 3RVAA 2BHDA 4IPAA 3L7GA 2GG8A 2GG0A 4U69A 1WBQA 4S2TP 1XGSA 2BH3A 2P99A 4FO7A 2GU6A 4IKTA 1C27A 3CB6A 4IKUA 1WLRA 1XNZA 1C23A 2BWXA 1C21A 4ZWUA 1A16A 1YW9A 5CE6A 1JAWA 2P9AA 3PKCA 3PKBA 4PV4A 2Q8KA 2Q92A 3Q6DA 4IU6A 2B3HA 3TB5A 4U70A 4EGEA 1XGOA 2V3ZA 1N51A 2B3LA 5CIKA 3MR1A 2Q93A 4IF7A 4U6CA 2NQ7A 5CLSA 4FLLA 2BWTA 2GG5A 1MATA 3CB5A 1W2MA 4S2RP 1B6AA 2MATA 3RORA 4RZZA 4ZNGA 5CNXA 4ZWPA 1YVMA 4U6EA 4A6WA 4U6JA 3BIPA 3BITA 4FO8A 2EVOA 1WKMA 4U73A 4U1BA 2EA2A 2GU7A 2HOWA 3FMQA 1CHMA 1WL6A 3S6BA 4FLJA 1BN5A 1WL9A 2Q94A 1R5HA 4JUQA 2GG3A 3BIQA 1R5GA 2IW2A 5D6EA 1Y1NA 4Z7MA 1M35A 5CDVA 5FCHA 5JFRA 2ZSGA 1QXWA 4IKSA 4A6VA 3IG4A 4U75A 2EVMA 4U6WA 2BB7A 5JHUA 3MX6A 4U76A 2NQ6A 2Q95A 4S00A 2GU5A 3PKDA 2GG9A 3TAVA 1WN1A 3MATA 1KP0A 2BN7A 2GGBA 1KQ9A 2GA2A 4FLIA 3CTZA 3L24A 4S01A 4IKRA 4ZWOA 2GZ5A 4MATA 1QZYA 1W7VA 1BOAA 1PV9A 5CDLA 4RGZ1 2BHCA 2P98A 2Q96A 4B28A 2BWVA 2V3XA 1C24A 4FKCA 2BWWA 4OOKA 2DFIA 4PNCA 1XGMA 2EA4A 2BWUA 3PKAA 1B59A 1O0XA 2OAZA 1QXYA 2GG2A 4IDYA 1R58A 1XGNA 2G6PA 1YW8A 4U71A 2GG7A 5FCFA 3IU9A 2B3KA 1WY2A 3D27A 2V3YA 4QR8A 4FLKA 2BHAA 1QXZA 3PKEA 5D6FA 3IU7A 4HXXA 1YJ3A 1YW7A 2OKNA 1KQ0A 3IU8A 2BHBA 2V6CA 2GGCA 2GU4A 5E5BA 5CDEA 2ADUA 3FMRA 2BWYA 5JI6A 4IECA
chains in the Genus database with same CATH superfamily
4U6ZA 4R60A 2GTXA 1C22A 2BWSA 2EVCA 4FUKA 4RZYA 4KM3A 3FM3A 3RVAA 2BHDA 4IPAA 3L7GA 2GG8A 2GG0A 4U69A 1WBQA 4S2TP 1XGSA 2BH3A 2P99A 4FO7A 2GU6A 4IKTA 1C27A 3CB6A 4IKUA 1WLRA 1XNZA 1C23A 2BWXA 1C21A 4ZWUA 1A16A 1YW9A 5CE6A 1JAWA 2P9AA 3PKCA 3PKBA 4PV4A 2Q8KA 2Q92A 3Q6DA 4IU6A 2B3HA 3TB5A 4U70A 4EGEA 1XGOA 2V3ZA 1N51A 2B3LA 5CIKA 3MR1A 2Q93A 4IF7A 4U6CA 2NQ7A 5CLSA 4FLLA 2BWTA 2GG5A 1MATA 3CB5A 1W2MA 4S2RP 1B6AA 2MATA 3RORA 4RZZA 4ZNGA 5CNXA 4ZWPA 1YVMA 4U6EA 4A6WA 4U6JA 3BIPA 3BITA 4FO8A 2EVOA 1WKMA 4U73A 4U1BA 2EA2A 2GU7A 2HOWA 3FMQA 1CHMA 1WL6A 3S6BA 4FLJA 1BN5A 1WL9A 2Q94A 1R5HA 4JUQA 2GG3A 3BIQA 1R5GA 2IW2A 5D6EA 1Y1NA 4Z7MA 1M35A 5CDVA 5FCHA 5JFRA 2ZSGA 1QXWA 4IKSA 4A6VA 3IG4A 4U75A 2EVMA 4U6WA 2BB7A 5JHUA 3MX6A 4U76A 2NQ6A 2Q95A 4S00A 2GU5A 3PKDA 2GG9A 3TAVA 1WN1A 3MATA 1KP0A 2BN7A 2GGBA 1KQ9A 2GA2A 4FLIA 3CTZA 3L24A 4S01A 4IKRA 4ZWOA 2GZ5A 4MATA 1QZYA 1W7VA 1BOAA 1PV9A 5CDLA 4RGZ1 2BHCA 2P98A 2Q96A 4B28A 2BWVA 2V3XA 1C24A 4FKCA 2BWWA 4OOKA 2DFIA 4PNCA 1XGMA 2EA4A 2BWUA 3PKAA 1B59A 1O0XA 2OAZA 1QXYA 2GG2A 4IDYA 1R58A 1XGNA 2G6PA 1YW8A 4U71A 2GG7A 5FCFA 3IU9A 2B3KA 1WY2A 3D27A 2V3YA 4QR8A 4FLKA 2BHAA 1QXZA 3PKEA 5D6FA 3IU7A 4HXXA 1YJ3A 1YW7A 2OKNA 1KQ0A 3IU8A 2BHBA 2V6CA 2GGCA 2GU4A 5E5BA 5CDEA 2ADUA 3FMRA 2BWYA 5JI6A 4IECA
chains in the Genus database with same CATH topology
4U6ZA 4R60A 2GTXA 1C22A 2BWSA 2EVCA 4FUKA 4RZYA 4KM3A 3FM3A 3RVAA 2BHDA 4IPAA 3L7GA 2GG8A 2GG0A 4U69A 1WBQA 4S2TP 1XGSA 2BH3A 2P99A 4FO7A 2GU6A 4IKTA 1C27A 3CB6A 4IKUA 1WLRA 1XNZA 1C23A 2BWXA 1C21A 4ZWUA 1A16A 1YW9A 5CE6A 1JAWA 2P9AA 3PKCA 3PKBA 4PV4A 2Q8KA 2Q92A 3Q6DA 4IU6A 2B3HA 3TB5A 4U70A 4EGEA 1XGOA 2V3ZA 1N51A 2B3LA 5CIKA 3MR1A 2Q93A 4IF7A 4U6CA 2NQ7A 5CLSA 4FLLA 2BWTA 2GG5A 1MATA 3CB5A 1W2MA 4S2RP 1B6AA 2MATA 3RORA 4RZZA 4ZNGA 5CNXA 4ZWPA 1YVMA 4U6EA 4A6WA 4U6JA 3BIPA 3BITA 4FO8A 2EVOA 1WKMA 4U73A 4U1BA 2EA2A 2GU7A 2HOWA 3FMQA 1CHMA 1WL6A 3S6BA 4FLJA 1BN5A 1WL9A 2Q94A 1R5HA 4JUQA 2GG3A 3BIQA 1R5GA 2IW2A 5D6EA 1Y1NA 4Z7MA 1M35A 5CDVA 5FCHA 5JFRA 2ZSGA 1QXWA 4IKSA 4A6VA 3IG4A 4U75A 2EVMA 4U6WA 2BB7A 5JHUA 3MX6A 4U76A 2NQ6A 2Q95A 4S00A 2GU5A 3PKDA 2GG9A 3TAVA 1WN1A 3MATA 1KP0A 2BN7A 2GGBA 1KQ9A 2GA2A 4FLIA 3CTZA 3L24A 4S01A 4IKRA 4ZWOA 2GZ5A 4MATA 1QZYA 1W7VA 1BOAA 1PV9A 5CDLA 4RGZ1 2BHCA 2P98A 2Q96A 4B28A 2BWVA 2V3XA 1C24A 4FKCA 2BWWA 4OOKA 2DFIA 4PNCA 1XGMA 2EA4A 2BWUA 3PKAA 1B59A 1O0XA 2OAZA 1QXYA 2GG2A 4IDYA 1R58A 1XGNA 2G6PA 1YW8A 4U71A 2GG7A 5FCFA 3IU9A 2B3KA 1WY2A 3D27A 2V3YA 4QR8A 4FLKA 2BHAA 1QXZA 3PKEA 5D6FA 3IU7A 4HXXA 1YJ3A 1YW7A 2OKNA 1KQ0A 3IU8A 2BHBA 2V6CA 2GGCA 2GU4A 5E5BA 5CDEA 2ADUA 3FMRA 2BWYA 5JI6A 4IECA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4U6Z A;  4R60 A;  2GTX A;  1C22 A;  2BWS A;  2EVC A;  4FUK A;  4RZY A;  4KM3 A;  3FM3 A;  3RVA A;  2BHD A;  4IPA A;  3L7G A;  2GG8 A;  2GG0 A;  4U69 A;  1WBQ A;  4S2T P;  1XGS A;  2BH3 A;  2P99 A;  4FO7 A;  2GU6 A;  4IKT A;  1C27 A;  3CB6 A;  4IKU A;  1WLR A;  1XNZ A;  1C23 A;  2BWX A;  1C21 A;  4ZWU A;  1A16 A;  1YW9 A;  5CE6 A;  1JAW A;  2P9A A;  3PKC A;  3PKB A;  4PV4 A;  2Q8K A;  2Q92 A;  3Q6D A;  4IU6 A;  2B3H A;  3TB5 A;  4U70 A;  4EGE A;  1XGO A;  2V3Z A;  1N51 A;  2B3L A;  5CIK A;  3MR1 A;  2Q93 A;  4IF7 A;  4U6C A;  2NQ7 A;  5CLS A;  4FLL A;  2BWT A;  2GG5 A;  1MAT A;  3CB5 A;  1W2M A;  4S2R P;  1B6A A;  2MAT A;  3ROR A;  4RZZ A;  4ZNG A;  5CNX A;  4ZWP A;  1YVM A;  4U6E A;  4A6W A;  4U6J A;  3BIP A;  3BIT A;  4FO8 A;  2EVO A;  1WKM A;  4U73 A;  4U1B A;  2EA2 A;  2GU7 A;  2HOW A;  3FMQ A;  1CHM A;  1WL6 A;  3S6B A;  4FLJ A;  1BN5 A;  1WL9 A;  2Q94 A;  1R5H A;  4JUQ A;  2GG3 A;  3BIQ A;  1R5G A;  2IW2 A;  5D6E A;  1Y1N A;  4Z7M A;  1M35 A;  5CDV A;  5FCH A;  5JFR A;  2ZSG A;  1QXW A;  4IKS A;  4A6V A;  3IG4 A;  4U75 A;  2EVM A;  4U6W A;  2BB7 A;  5JHU A;  3MX6 A;  4U76 A;  2NQ6 A;  2Q95 A;  4S00 A;  2GU5 A;  3PKD A;  2GG9 A;  3TAV A;  1WN1 A;  3MAT A;  1KP0 A;  2BN7 A;  2GGB A;  1KQ9 A;  2GA2 A;  4FLI A;  3CTZ A;  3L24 A;  4S01 A;  4IKR A;  4ZWO A;  2GZ5 A;  4MAT A;  1QZY A;  1W7V A;  1BOA A;  1PV9 A;  5CDL A;  4RGZ 1;  2BHC A;  2P98 A;  2Q96 A;  4B28 A;  2BWV A;  2V3X A;  1C24 A;  4FKC A;  2BWW A;  4OOK A;  2DFI A;  4PNC A;  1XGM A;  2EA4 A;  2BWU A;  3PKA A;  1B59 A;  1O0X A;  2OAZ A;  1QXY A;  2GG2 A;  4IDY A;  1R58 A;  1XGN A;  2G6P A;  1YW8 A;  4U71 A;  2GG7 A;  5FCF A;  3IU9 A;  2B3K A;  1WY2 A;  3D27 A;  2V3Y A;  4QR8 A;  4FLK A;  2BHA A;  1QXZ A;  3PKE A;  5D6F A;  3IU7 A;  4HXX A;  1YJ3 A;  1YW7 A;  2OKN A;  1KQ0 A;  3IU8 A;  2BHB A;  2V6C A;  2GGC A;  2GU4 A;  5E5B A;  5CDE A;  2ADU A;  3FMR A;  2BWY A;  5JI6 A;  4IEC A; 
#chains in the Genus database with same CATH topology
 4U6Z A;  4R60 A;  2GTX A;  1C22 A;  2BWS A;  2EVC A;  4FUK A;  4RZY A;  4KM3 A;  3FM3 A;  3RVA A;  2BHD A;  4IPA A;  3L7G A;  2GG8 A;  2GG0 A;  4U69 A;  1WBQ A;  4S2T P;  1XGS A;  2BH3 A;  2P99 A;  4FO7 A;  2GU6 A;  4IKT A;  1C27 A;  3CB6 A;  4IKU A;  1WLR A;  1XNZ A;  1C23 A;  2BWX A;  1C21 A;  4ZWU A;  1A16 A;  1YW9 A;  5CE6 A;  1JAW A;  2P9A A;  3PKC A;  3PKB A;  4PV4 A;  2Q8K A;  2Q92 A;  3Q6D A;  4IU6 A;  2B3H A;  3TB5 A;  4U70 A;  4EGE A;  1XGO A;  2V3Z A;  1N51 A;  2B3L A;  5CIK A;  3MR1 A;  2Q93 A;  4IF7 A;  4U6C A;  2NQ7 A;  5CLS A;  4FLL A;  2BWT A;  2GG5 A;  1MAT A;  3CB5 A;  1W2M A;  4S2R P;  1B6A A;  2MAT A;  3ROR A;  4RZZ A;  4ZNG A;  5CNX A;  4ZWP A;  1YVM A;  4U6E A;  4A6W A;  4U6J A;  3BIP A;  3BIT A;  4FO8 A;  2EVO A;  1WKM A;  4U73 A;  4U1B A;  2EA2 A;  2GU7 A;  2HOW A;  3FMQ A;  1CHM A;  1WL6 A;  3S6B A;  4FLJ A;  1BN5 A;  1WL9 A;  2Q94 A;  1R5H A;  4JUQ A;  2GG3 A;  3BIQ A;  1R5G A;  2IW2 A;  5D6E A;  1Y1N A;  4Z7M A;  1M35 A;  5CDV A;  5FCH A;  5JFR A;  2ZSG A;  1QXW A;  4IKS A;  4A6V A;  3IG4 A;  4U75 A;  2EVM A;  4U6W A;  2BB7 A;  5JHU A;  3MX6 A;  4U76 A;  2NQ6 A;  2Q95 A;  4S00 A;  2GU5 A;  3PKD A;  2GG9 A;  3TAV A;  1WN1 A;  3MAT A;  1KP0 A;  2BN7 A;  2GGB A;  1KQ9 A;  2GA2 A;  4FLI A;  3CTZ A;  3L24 A;  4S01 A;  4IKR A;  4ZWO A;  2GZ5 A;  4MAT A;  1QZY A;  1W7V A;  1BOA A;  1PV9 A;  5CDL A;  4RGZ 1;  2BHC A;  2P98 A;  2Q96 A;  4B28 A;  2BWV A;  2V3X A;  1C24 A;  4FKC A;  2BWW A;  4OOK A;  2DFI A;  4PNC A;  1XGM A;  2EA4 A;  2BWU A;  3PKA A;  1B59 A;  1O0X A;  2OAZ A;  1QXY A;  2GG2 A;  4IDY A;  1R58 A;  1XGN A;  2G6P A;  1YW8 A;  4U71 A;  2GG7 A;  5FCF A;  3IU9 A;  2B3K A;  1WY2 A;  3D27 A;  2V3Y A;  4QR8 A;  4FLK A;  2BHA A;  1QXZ A;  3PKE A;  5D6F A;  3IU7 A;  4HXX A;  1YJ3 A;  1YW7 A;  2OKN A;  1KQ0 A;  3IU8 A;  2BHB A;  2V6C A;  2GGC A;  2GU4 A;  5E5B A;  5CDE A;  2ADU A;  3FMR A;  2BWY A;  5JI6 A;  4IEC A; 
#chains in the Genus database with same CATH homology
 4U6Z A;  4R60 A;  2GTX A;  1C22 A;  2BWS A;  2EVC A;  4FUK A;  4RZY A;  4KM3 A;  3FM3 A;  3RVA A;  2BHD A;  4IPA A;  3L7G A;  2GG8 A;  2GG0 A;  4U69 A;  1WBQ A;  4S2T P;  1XGS A;  2BH3 A;  2P99 A;  4FO7 A;  2GU6 A;  4IKT A;  1C27 A;  3CB6 A;  4IKU A;  1WLR A;  1XNZ A;  1C23 A;  2BWX A;  1C21 A;  4ZWU A;  1A16 A;  1YW9 A;  5CE6 A;  1JAW A;  2P9A A;  3PKC A;  3PKB A;  4PV4 A;  2Q8K A;  2Q92 A;  3Q6D A;  4IU6 A;  2B3H A;  3TB5 A;  4U70 A;  4EGE A;  1XGO A;  2V3Z A;  1N51 A;  2B3L A;  5CIK A;  3MR1 A;  2Q93 A;  4IF7 A;  4U6C A;  2NQ7 A;  5CLS A;  4FLL A;  2BWT A;  2GG5 A;  1MAT A;  3CB5 A;  1W2M A;  4S2R P;  1B6A A;  2MAT A;  3ROR A;  4RZZ A;  4ZNG A;  5CNX A;  4ZWP A;  1YVM A;  4U6E A;  4A6W A;  4U6J A;  3BIP A;  3BIT A;  4FO8 A;  2EVO A;  1WKM A;  4U73 A;  4U1B A;  2EA2 A;  2GU7 A;  2HOW A;  3FMQ A;  1CHM A;  1WL6 A;  3S6B A;  4FLJ A;  1BN5 A;  1WL9 A;  2Q94 A;  1R5H A;  4JUQ A;  2GG3 A;  3BIQ A;  1R5G A;  2IW2 A;  5D6E A;  1Y1N A;  4Z7M A;  1M35 A;  5CDV A;  5FCH A;  5JFR A;  2ZSG A;  1QXW A;  4IKS A;  4A6V A;  3IG4 A;  4U75 A;  2EVM A;  4U6W A;  2BB7 A;  5JHU A;  3MX6 A;  4U76 A;  2NQ6 A;  2Q95 A;  4S00 A;  2GU5 A;  3PKD A;  2GG9 A;  3TAV A;  1WN1 A;  3MAT A;  1KP0 A;  2BN7 A;  2GGB A;  1KQ9 A;  2GA2 A;  4FLI A;  3CTZ A;  3L24 A;  4S01 A;  4IKR A;  4ZWO A;  2GZ5 A;  4MAT A;  1QZY A;  1W7V A;  1BOA A;  1PV9 A;  5CDL A;  4RGZ 1;  2BHC A;  2P98 A;  2Q96 A;  4B28 A;  2BWV A;  2V3X A;  1C24 A;  4FKC A;  2BWW A;  4OOK A;  2DFI A;  4PNC A;  1XGM A;  2EA4 A;  2BWU A;  3PKA A;  1B59 A;  1O0X A;  2OAZ A;  1QXY A;  2GG2 A;  4IDY A;  1R58 A;  1XGN A;  2G6P A;  1YW8 A;  4U71 A;  2GG7 A;  5FCF A;  3IU9 A;  2B3K A;  1WY2 A;  3D27 A;  2V3Y A;  4QR8 A;  4FLK A;  2BHA A;  1QXZ A;  3PKE A;  5D6F A;  3IU7 A;  4HXX A;  1YJ3 A;  1YW7 A;  2OKN A;  1KQ0 A;  3IU8 A;  2BHB A;  2V6C A;  2GGC A;  2GU4 A;  5E5B A;  5CDE A;  2ADU A;  3FMR A;  2BWY A;  5JI6 A;  4IEC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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