4OOKA

Third metal bound m.tuberculosis methionine aminopeptidase
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
282
structure length
282
Chain Sequence
RTALSPGVLSPTRPVPNWIARPEYVGKPAAQEGSEPWVQTPEVIEKMRVAGRIAAGALAEAGKAVAPGVTTDELDRIAHEYLVDNGAYPSTLGYKGFPKSCCTSLNEVICHGIPDSTVITDGDIVNIDVTAYIGGVHGDTNATFPAGDVADEHRLLVDRTREATMRAINTVKPGRALSVIGRVIESYANRFGYNVVRDFTGHGIGTTFHNGLVVLHYDQPAVETIMQPGMTFTIEPMINLGALDYEIWDDGWTVVTKDRKWTAQFEHTLLVTDTGVEILTAL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Selective targeting of the conserved active site cysteine of Mycobacterium tuberculosis methionine aminopeptidase with electrophilic reagents
pubmed doi rcsb
molecule tags Hydrolase
source organism Mycobacterium tuberculosis
molecule keywords Methionine aminopeptidase 2
total genus 88
structure length 282
sequence length 282
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-02-03

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4ookA01
1JAWA 3BIPA 4QR8A 4S2TP 4ZNGA 2GU5A 3FMRA 4ZWUA 3CB5A 2OAZA 5FCHA 2GU7A 3IU7A 2B3KA 4EGEA 4S2RP 4U1BA 1WBQA 1QXYA 1R5HA 4U75A 1YJ3A 3CTZA 2GGBA 1C24A 3BIQA 3CB6A 1KQ9A 1C23A 3MX6A 3PKEA 5E5BA 4RZYA 4KM3A 3RVAA 2Q96A 2MATA 1B59A 5JHUA 2ADUA 4A6VA 1Y1NA 1MATA 4IKSA 5CDVA 1WL6A 1YVMA 3L7GA 1CHMA 4U6WA 1YW7A 2Q92A 4IKTA 4PNCA 1WL9A 1XGSA 3FM3A 2GG5A 2GA2A 3D27A 2BHBA 2BWVA 1QXZA 2EVOA 3IG4A 4FLKA 3RORA 4RGZ1 5CDLA 3PKDA 2BWWA 3BITA 1XNZA 4IKUA 4U71A 2GZ5A 4U73A 1KQ0A 2GG3A 4FLIA 2P9AA 2Q8KA 2V3YA 1C21A 1A16A 1YW8A 3L24A 2P98A 2BWUA 2BN7A 2GG9A 1XGMA 5CIKA 2HOWA 1QXWA 2NQ6A 4FKCA 5JFRA 2BWSA 3FMQA 2V3XA 5CNXA 1PV9A 2BHCA 1WKMA 5JI6A 2IW2A 4IECA 1WN1A 2V3ZA 4U6ZA 2G6PA 4S01A 1XGOA 4U76A 1R58A 2DFIA 2NQ7A 1C22A 5CLSA 4U6JA 2EVMA 2EA2A 4Z7MA 1KP0A 1BOAA 4FLJA 4U6EA 1BN5A 2BWTA 2EVCA 3MATA 4FO7A 4FO8A 3PKAA 4S00A 1C27A 4R60A 4A6WA 4B28A 2EA4A 2B3LA 1WY2A 3Q6DA 2BWYA 3S6BA 1M35A 2GG8A 2GU6A 2GU4A 3IU8A 4U6CA 5FCFA 4IKRA 4MATA 2P99A 1QZYA 4JUQA 5CE6A 4RZZA 2BWXA 2GG7A 5D6FA 2B3HA 4IF7A 1YW9A 1W7VA 5CDEA 2ZSGA 3TB5A 2V6CA 2Q93A 4PV4A 1N51A 1R5GA 4IPAA 4IU6A 2OKNA 2GGCA 2BHAA 2Q95A 4FLLA 1B6AA 5D6EA 3IU9A 1WLRA 2GG0A 2BB7A 4ZWOA 4ZWPA 3PKBA 4HXXA 4FUKA 2GG2A 3MR1A 4U69A 3TAVA 1W2MA 3PKCA 1O0XA 1XGNA 2Q94A 4U70A 2BH3A 2GTXA 2BHDA 4OOKA 4IDYA
chains in the Genus database with same CATH superfamily
1JAWA 3BIPA 4QR8A 4S2TP 4ZNGA 2GU5A 3FMRA 4ZWUA 3CB5A 2OAZA 5FCHA 2GU7A 3IU7A 2B3KA 4EGEA 4S2RP 4U1BA 1WBQA 1QXYA 1R5HA 4U75A 1YJ3A 3CTZA 2GGBA 1C24A 3BIQA 3CB6A 1KQ9A 1C23A 3MX6A 3PKEA 5E5BA 4RZYA 4KM3A 3RVAA 2Q96A 2MATA 1B59A 5JHUA 2ADUA 4A6VA 1Y1NA 1MATA 4IKSA 5CDVA 1WL6A 1YVMA 3L7GA 1CHMA 4U6WA 1YW7A 2Q92A 4IKTA 4PNCA 1WL9A 1XGSA 3FM3A 2GG5A 2GA2A 3D27A 2BHBA 2BWVA 1QXZA 2EVOA 3IG4A 4FLKA 3RORA 4RGZ1 5CDLA 3PKDA 2BWWA 3BITA 1XNZA 4IKUA 4U71A 2GZ5A 4U73A 1KQ0A 2GG3A 4FLIA 2P9AA 2Q8KA 2V3YA 1C21A 1A16A 1YW8A 3L24A 2P98A 2BWUA 2BN7A 2GG9A 1XGMA 5CIKA 2HOWA 1QXWA 2NQ6A 4FKCA 5JFRA 2BWSA 3FMQA 2V3XA 5CNXA 1PV9A 2BHCA 1WKMA 5JI6A 2IW2A 4IECA 1WN1A 2V3ZA 4U6ZA 2G6PA 4S01A 1XGOA 4U76A 1R58A 2DFIA 2NQ7A 1C22A 5CLSA 4U6JA 2EVMA 2EA2A 4Z7MA 1KP0A 1BOAA 4FLJA 4U6EA 1BN5A 2BWTA 2EVCA 3MATA 4FO7A 4FO8A 3PKAA 4S00A 1C27A 4R60A 4A6WA 4B28A 2EA4A 2B3LA 1WY2A 3Q6DA 2BWYA 3S6BA 1M35A 2GG8A 2GU6A 2GU4A 3IU8A 4U6CA 5FCFA 4IKRA 4MATA 2P99A 1QZYA 4JUQA 5CE6A 4RZZA 2BWXA 2GG7A 5D6FA 2B3HA 4IF7A 1YW9A 1W7VA 5CDEA 2ZSGA 3TB5A 2V6CA 2Q93A 4PV4A 1N51A 1R5GA 4IPAA 4IU6A 2OKNA 2GGCA 2BHAA 2Q95A 4FLLA 1B6AA 5D6EA 3IU9A 1WLRA 2GG0A 2BB7A 4ZWOA 4ZWPA 3PKBA 4HXXA 4FUKA 2GG2A 3MR1A 4U69A 3TAVA 1W2MA 3PKCA 1O0XA 1XGNA 2Q94A 4U70A 2BH3A 2GTXA 2BHDA 4OOKA 4IDYA
chains in the Genus database with same CATH topology
1JAWA 3BIPA 4QR8A 4S2TP 4ZNGA 2GU5A 3FMRA 4ZWUA 3CB5A 2OAZA 5FCHA 2GU7A 3IU7A 2B3KA 4EGEA 4S2RP 4U1BA 1WBQA 1QXYA 1R5HA 4U75A 1YJ3A 3CTZA 2GGBA 1C24A 3BIQA 3CB6A 1KQ9A 1C23A 3MX6A 3PKEA 5E5BA 4RZYA 4KM3A 3RVAA 2Q96A 2MATA 1B59A 5JHUA 2ADUA 4A6VA 1Y1NA 1MATA 4IKSA 5CDVA 1WL6A 1YVMA 3L7GA 1CHMA 4U6WA 1YW7A 2Q92A 4IKTA 4PNCA 1WL9A 1XGSA 3FM3A 2GG5A 2GA2A 3D27A 2BHBA 2BWVA 1QXZA 2EVOA 3IG4A 4FLKA 3RORA 4RGZ1 5CDLA 3PKDA 2BWWA 3BITA 1XNZA 4IKUA 4U71A 2GZ5A 4U73A 1KQ0A 2GG3A 4FLIA 2P9AA 2Q8KA 2V3YA 1C21A 1A16A 1YW8A 3L24A 2P98A 2BWUA 2BN7A 2GG9A 1XGMA 5CIKA 2HOWA 1QXWA 2NQ6A 4FKCA 5JFRA 2BWSA 3FMQA 2V3XA 5CNXA 1PV9A 2BHCA 1WKMA 5JI6A 2IW2A 4IECA 1WN1A 2V3ZA 4U6ZA 2G6PA 4S01A 1XGOA 4U76A 1R58A 2DFIA 2NQ7A 1C22A 5CLSA 4U6JA 2EVMA 2EA2A 4Z7MA 1KP0A 1BOAA 4FLJA 4U6EA 1BN5A 2BWTA 2EVCA 3MATA 4FO7A 4FO8A 3PKAA 4S00A 1C27A 4R60A 4A6WA 4B28A 2EA4A 2B3LA 1WY2A 3Q6DA 2BWYA 3S6BA 1M35A 2GG8A 2GU6A 2GU4A 3IU8A 4U6CA 5FCFA 4IKRA 4MATA 2P99A 1QZYA 4JUQA 5CE6A 4RZZA 2BWXA 2GG7A 5D6FA 2B3HA 4IF7A 1YW9A 1W7VA 5CDEA 2ZSGA 3TB5A 2V6CA 2Q93A 4PV4A 1N51A 1R5GA 4IPAA 4IU6A 2OKNA 2GGCA 2BHAA 2Q95A 4FLLA 1B6AA 5D6EA 3IU9A 1WLRA 2GG0A 2BB7A 4ZWOA 4ZWPA 3PKBA 4HXXA 4FUKA 2GG2A 3MR1A 4U69A 3TAVA 1W2MA 3PKCA 1O0XA 1XGNA 2Q94A 4U70A 2BH3A 2GTXA 2BHDA 4OOKA 4IDYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1JAW A;  3BIP A;  4QR8 A;  4S2T P;  4ZNG A;  2GU5 A;  3FMR A;  4ZWU A;  3CB5 A;  2OAZ A;  5FCH A;  2GU7 A;  3IU7 A;  2B3K A;  4EGE A;  4S2R P;  4U1B A;  1WBQ A;  1QXY A;  1R5H A;  4U75 A;  1YJ3 A;  3CTZ A;  2GGB A;  1C24 A;  3BIQ A;  3CB6 A;  1KQ9 A;  1C23 A;  3MX6 A;  3PKE A;  5E5B A;  4RZY A;  4KM3 A;  3RVA A;  2Q96 A;  2MAT A;  1B59 A;  5JHU A;  2ADU A;  4A6V A;  1Y1N A;  1MAT A;  4IKS A;  5CDV A;  1WL6 A;  1YVM A;  3L7G A;  1CHM A;  4U6W A;  1YW7 A;  2Q92 A;  4IKT A;  4PNC A;  1WL9 A;  1XGS A;  3FM3 A;  2GG5 A;  2GA2 A;  3D27 A;  2BHB A;  2BWV A;  1QXZ A;  2EVO A;  3IG4 A;  4FLK A;  3ROR A;  4RGZ 1;  5CDL A;  3PKD A;  2BWW A;  3BIT A;  1XNZ A;  4IKU A;  4U71 A;  2GZ5 A;  4U73 A;  1KQ0 A;  2GG3 A;  4FLI A;  2P9A A;  2Q8K A;  2V3Y A;  1C21 A;  1A16 A;  1YW8 A;  3L24 A;  2P98 A;  2BWU A;  2BN7 A;  2GG9 A;  1XGM A;  5CIK A;  2HOW A;  1QXW A;  2NQ6 A;  4FKC A;  5JFR A;  2BWS A;  3FMQ A;  2V3X A;  5CNX A;  1PV9 A;  2BHC A;  1WKM A;  5JI6 A;  2IW2 A;  4IEC A;  1WN1 A;  2V3Z A;  4U6Z A;  2G6P A;  4S01 A;  1XGO A;  4U76 A;  1R58 A;  2DFI A;  2NQ7 A;  1C22 A;  5CLS A;  4U6J A;  2EVM A;  2EA2 A;  4Z7M A;  1KP0 A;  1BOA A;  4FLJ A;  4U6E A;  1BN5 A;  2BWT A;  2EVC A;  3MAT A;  4FO7 A;  4FO8 A;  3PKA A;  4S00 A;  1C27 A;  4R60 A;  4A6W A;  4B28 A;  2EA4 A;  2B3L A;  1WY2 A;  3Q6D A;  2BWY A;  3S6B A;  1M35 A;  2GG8 A;  2GU6 A;  2GU4 A;  3IU8 A;  4U6C A;  5FCF A;  4IKR A;  4MAT A;  2P99 A;  1QZY A;  4JUQ A;  5CE6 A;  4RZZ A;  2BWX A;  2GG7 A;  5D6F A;  2B3H A;  4IF7 A;  1YW9 A;  1W7V A;  5CDE A;  2ZSG A;  3TB5 A;  2V6C A;  2Q93 A;  4PV4 A;  1N51 A;  1R5G A;  4IPA A;  4IU6 A;  2OKN A;  2GGC A;  2BHA A;  2Q95 A;  4FLL A;  1B6A A;  5D6E A;  3IU9 A;  1WLR A;  2GG0 A;  2BB7 A;  4ZWO A;  4ZWP A;  3PKB A;  4HXX A;  4FUK A;  2GG2 A;  3MR1 A;  4U69 A;  3TAV A;  1W2M A;  3PKC A;  1O0X A;  1XGN A;  2Q94 A;  4U70 A;  2BH3 A;  2GTX A;  2BHD A;  4OOK A;  4IDY A; 
#chains in the Genus database with same CATH topology
 1JAW A;  3BIP A;  4QR8 A;  4S2T P;  4ZNG A;  2GU5 A;  3FMR A;  4ZWU A;  3CB5 A;  2OAZ A;  5FCH A;  2GU7 A;  3IU7 A;  2B3K A;  4EGE A;  4S2R P;  4U1B A;  1WBQ A;  1QXY A;  1R5H A;  4U75 A;  1YJ3 A;  3CTZ A;  2GGB A;  1C24 A;  3BIQ A;  3CB6 A;  1KQ9 A;  1C23 A;  3MX6 A;  3PKE A;  5E5B A;  4RZY A;  4KM3 A;  3RVA A;  2Q96 A;  2MAT A;  1B59 A;  5JHU A;  2ADU A;  4A6V A;  1Y1N A;  1MAT A;  4IKS A;  5CDV A;  1WL6 A;  1YVM A;  3L7G A;  1CHM A;  4U6W A;  1YW7 A;  2Q92 A;  4IKT A;  4PNC A;  1WL9 A;  1XGS A;  3FM3 A;  2GG5 A;  2GA2 A;  3D27 A;  2BHB A;  2BWV A;  1QXZ A;  2EVO A;  3IG4 A;  4FLK A;  3ROR A;  4RGZ 1;  5CDL A;  3PKD A;  2BWW A;  3BIT A;  1XNZ A;  4IKU A;  4U71 A;  2GZ5 A;  4U73 A;  1KQ0 A;  2GG3 A;  4FLI A;  2P9A A;  2Q8K A;  2V3Y A;  1C21 A;  1A16 A;  1YW8 A;  3L24 A;  2P98 A;  2BWU A;  2BN7 A;  2GG9 A;  1XGM A;  5CIK A;  2HOW A;  1QXW A;  2NQ6 A;  4FKC A;  5JFR A;  2BWS A;  3FMQ A;  2V3X A;  5CNX A;  1PV9 A;  2BHC A;  1WKM A;  5JI6 A;  2IW2 A;  4IEC A;  1WN1 A;  2V3Z A;  4U6Z A;  2G6P A;  4S01 A;  1XGO A;  4U76 A;  1R58 A;  2DFI A;  2NQ7 A;  1C22 A;  5CLS A;  4U6J A;  2EVM A;  2EA2 A;  4Z7M A;  1KP0 A;  1BOA A;  4FLJ A;  4U6E A;  1BN5 A;  2BWT A;  2EVC A;  3MAT A;  4FO7 A;  4FO8 A;  3PKA A;  4S00 A;  1C27 A;  4R60 A;  4A6W A;  4B28 A;  2EA4 A;  2B3L A;  1WY2 A;  3Q6D A;  2BWY A;  3S6B A;  1M35 A;  2GG8 A;  2GU6 A;  2GU4 A;  3IU8 A;  4U6C A;  5FCF A;  4IKR A;  4MAT A;  2P99 A;  1QZY A;  4JUQ A;  5CE6 A;  4RZZ A;  2BWX A;  2GG7 A;  5D6F A;  2B3H A;  4IF7 A;  1YW9 A;  1W7V A;  5CDE A;  2ZSG A;  3TB5 A;  2V6C A;  2Q93 A;  4PV4 A;  1N51 A;  1R5G A;  4IPA A;  4IU6 A;  2OKN A;  2GGC A;  2BHA A;  2Q95 A;  4FLL A;  1B6A A;  5D6E A;  3IU9 A;  1WLR A;  2GG0 A;  2BB7 A;  4ZWO A;  4ZWP A;  3PKB A;  4HXX A;  4FUK A;  2GG2 A;  3MR1 A;  4U69 A;  3TAV A;  1W2M A;  3PKC A;  1O0X A;  1XGN A;  2Q94 A;  4U70 A;  2BH3 A;  2GTX A;  2BHD A;  4OOK A;  4IDY A; 
#chains in the Genus database with same CATH homology
 1JAW A;  3BIP A;  4QR8 A;  4S2T P;  4ZNG A;  2GU5 A;  3FMR A;  4ZWU A;  3CB5 A;  2OAZ A;  5FCH A;  2GU7 A;  3IU7 A;  2B3K A;  4EGE A;  4S2R P;  4U1B A;  1WBQ A;  1QXY A;  1R5H A;  4U75 A;  1YJ3 A;  3CTZ A;  2GGB A;  1C24 A;  3BIQ A;  3CB6 A;  1KQ9 A;  1C23 A;  3MX6 A;  3PKE A;  5E5B A;  4RZY A;  4KM3 A;  3RVA A;  2Q96 A;  2MAT A;  1B59 A;  5JHU A;  2ADU A;  4A6V A;  1Y1N A;  1MAT A;  4IKS A;  5CDV A;  1WL6 A;  1YVM A;  3L7G A;  1CHM A;  4U6W A;  1YW7 A;  2Q92 A;  4IKT A;  4PNC A;  1WL9 A;  1XGS A;  3FM3 A;  2GG5 A;  2GA2 A;  3D27 A;  2BHB A;  2BWV A;  1QXZ A;  2EVO A;  3IG4 A;  4FLK A;  3ROR A;  4RGZ 1;  5CDL A;  3PKD A;  2BWW A;  3BIT A;  1XNZ A;  4IKU A;  4U71 A;  2GZ5 A;  4U73 A;  1KQ0 A;  2GG3 A;  4FLI A;  2P9A A;  2Q8K A;  2V3Y A;  1C21 A;  1A16 A;  1YW8 A;  3L24 A;  2P98 A;  2BWU A;  2BN7 A;  2GG9 A;  1XGM A;  5CIK A;  2HOW A;  1QXW A;  2NQ6 A;  4FKC A;  5JFR A;  2BWS A;  3FMQ A;  2V3X A;  5CNX A;  1PV9 A;  2BHC A;  1WKM A;  5JI6 A;  2IW2 A;  4IEC A;  1WN1 A;  2V3Z A;  4U6Z A;  2G6P A;  4S01 A;  1XGO A;  4U76 A;  1R58 A;  2DFI A;  2NQ7 A;  1C22 A;  5CLS A;  4U6J A;  2EVM A;  2EA2 A;  4Z7M A;  1KP0 A;  1BOA A;  4FLJ A;  4U6E A;  1BN5 A;  2BWT A;  2EVC A;  3MAT A;  4FO7 A;  4FO8 A;  3PKA A;  4S00 A;  1C27 A;  4R60 A;  4A6W A;  4B28 A;  2EA4 A;  2B3L A;  1WY2 A;  3Q6D A;  2BWY A;  3S6B A;  1M35 A;  2GG8 A;  2GU6 A;  2GU4 A;  3IU8 A;  4U6C A;  5FCF A;  4IKR A;  4MAT A;  2P99 A;  1QZY A;  4JUQ A;  5CE6 A;  4RZZ A;  2BWX A;  2GG7 A;  5D6F A;  2B3H A;  4IF7 A;  1YW9 A;  1W7V A;  5CDE A;  2ZSG A;  3TB5 A;  2V6C A;  2Q93 A;  4PV4 A;  1N51 A;  1R5G A;  4IPA A;  4IU6 A;  2OKN A;  2GGC A;  2BHA A;  2Q95 A;  4FLL A;  1B6A A;  5D6E A;  3IU9 A;  1WLR A;  2GG0 A;  2BB7 A;  4ZWO A;  4ZWP A;  3PKB A;  4HXX A;  4FUK A;  2GG2 A;  3MR1 A;  4U69 A;  3TAV A;  1W2M A;  3PKC A;  1O0X A;  1XGN A;  2Q94 A;  4U70 A;  2BH3 A;  2GTX A;  2BHD A;  4OOK A;  4IDY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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