4PNCA

E. coli methionine aminopeptidase in complex with inhibitor 7-methoxy-2-methylen-3,4-dihydronaphthalen-1(2h)-one
Total Genus 88
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
88
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
source organism Escherichia coli
publication title Beta-aminoketones as prodrugs for selective irreversible inhibitors of type-1 methionine aminopeptidases.
pubmed doi rcsb
molecule keywords Methionine aminopeptidase
total genus 88
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4pncA00
2V6CA 3MX6A 3CB5A 4U6ZA 5D6FA 4PNCA 2BN7A 4U70A 4S2TP 4Z7MA 3PKBA 2DFIA 1XGSA 4MATA 2BWXA 1R58A 4RGZ1 1WN1A 2GG8A 2B3LA 2Q8KA 2GG5A 2GG7A 3IU7A 4U6EA 4U75A 5D6EA 1YW9A 5CDLA 1QXYA 1WBQA 3L7GA 2BHAA 1YJ3A 1BN5A 2B3KA 2GGBA 2GU6A 4U6CA 4B28A 1XGOA 4U6WA 4FLKA 1N51A 3TB5A 3IU9A 2EVMA 2EVOA 1B59A 4U69A 1CHMA 4QR8A 4S01A 2GGCA 1KQ0A 1YW8A 3BIPA 5FCHA 1C23A 3BITA 4S2RP 4FLLA 2OKNA 1Y1NA 2BWSA 2Q94A 1MATA 1YW7A 4RZYA 2BHDA 4U73A 2BWVA 4KM3A 4FUKA 2IW2A 2GG9A 4ZNGA 5FCFA 3FMRA 4U6JA 3D27A 4FKCA 1YVMA 1XGNA 1WKMA 3RVAA 2B3HA 3BIQA 5CIKA 4A6VA 1O0XA 4RZZA 4S00A 4IKRA 2P98A 1R5HA 3S6BA 2BWYA 4FLJA 1C22A 1PV9A 4IPAA 2BWWA 1A16A 5CLSA 2ADUA 4R60A 1C24A 3PKEA 5CE6A 1KP0A 1WLRA 1W2MA 1QXWA 2EA4A 4IKTA 4U1BA 1M35A 1C27A 2BB7A 1C21A 2BWTA 2GU5A 2MATA 2NQ7A 4FO8A 2G6PA 4IU6A 4IDYA 2V3YA 2Q96A 1W7VA 5JI6A 4U76A 3CTZA 4IF7A 4OOKA 1KQ9A 4IKUA 4IKSA 2Q95A 1BOAA 2Q92A 1WL9A 2Q93A 5CDEA 2BHCA 2GG3A 3Q6DA 1WY2A 5JFRA 4PV4A 1WL6A 2BHBA 2HOWA 2P9AA 2GG0A 1QZYA 2GA2A 2V3XA 5E5BA 3PKDA 4ZWOA 4ZWPA 4ZWUA 4FLIA 1B6AA 2EA2A 2GG2A 2BH3A 2NQ6A 5JHUA 2GU4A 3FM3A 3TAVA 1XGMA 3MATA 2EVCA 2GTXA 2P99A 3CB6A 3PKCA 4HXXA 4U71A 1R5GA 3L24A 5CNXA 2GU7A 4JUQA 3IG4A 2OAZA 5CDVA 1XNZA 3RORA 4FO7A 4A6WA 3FMQA 2V3ZA 3MR1A 2GZ5A 4EGEA 3PKAA 3IU8A 2BWUA 1QXZA 2ZSGA 4IECA 1JAWA
chains in the Genus database with same CATH superfamily
2V6CA 3MX6A 3CB5A 4U6ZA 5D6FA 4PNCA 2BN7A 4U70A 4S2TP 4Z7MA 3PKBA 2DFIA 1XGSA 4MATA 2BWXA 1R58A 4RGZ1 1WN1A 2GG8A 2B3LA 2Q8KA 2GG5A 2GG7A 3IU7A 4U6EA 4U75A 5D6EA 1YW9A 5CDLA 1QXYA 1WBQA 3L7GA 2BHAA 1YJ3A 1BN5A 2B3KA 2GGBA 2GU6A 4U6CA 4B28A 1XGOA 4U6WA 4FLKA 1N51A 3TB5A 3IU9A 2EVMA 2EVOA 1B59A 4U69A 1CHMA 4QR8A 4S01A 2GGCA 1KQ0A 1YW8A 3BIPA 5FCHA 1C23A 3BITA 4S2RP 4FLLA 2OKNA 1Y1NA 2BWSA 2Q94A 1MATA 1YW7A 4RZYA 2BHDA 4U73A 2BWVA 4KM3A 4FUKA 2IW2A 2GG9A 4ZNGA 5FCFA 3FMRA 4U6JA 3D27A 4FKCA 1YVMA 1XGNA 1WKMA 3RVAA 2B3HA 3BIQA 5CIKA 4A6VA 1O0XA 4RZZA 4S00A 4IKRA 2P98A 1R5HA 3S6BA 2BWYA 4FLJA 1C22A 1PV9A 4IPAA 2BWWA 1A16A 5CLSA 2ADUA 4R60A 1C24A 3PKEA 5CE6A 1KP0A 1WLRA 1W2MA 1QXWA 2EA4A 4IKTA 4U1BA 1M35A 1C27A 2BB7A 1C21A 2BWTA 2GU5A 2MATA 2NQ7A 4FO8A 2G6PA 4IU6A 4IDYA 2V3YA 2Q96A 1W7VA 5JI6A 4U76A 3CTZA 4IF7A 4OOKA 1KQ9A 4IKUA 4IKSA 2Q95A 1BOAA 2Q92A 1WL9A 2Q93A 5CDEA 2BHCA 2GG3A 3Q6DA 1WY2A 5JFRA 4PV4A 1WL6A 2BHBA 2HOWA 2P9AA 2GG0A 1QZYA 2GA2A 2V3XA 5E5BA 3PKDA 4ZWOA 4ZWPA 4ZWUA 4FLIA 1B6AA 2EA2A 2GG2A 2BH3A 2NQ6A 5JHUA 2GU4A 3FM3A 3TAVA 1XGMA 3MATA 2EVCA 2GTXA 2P99A 3CB6A 3PKCA 4HXXA 4U71A 1R5GA 3L24A 5CNXA 2GU7A 4JUQA 3IG4A 2OAZA 5CDVA 1XNZA 3RORA 4FO7A 4A6WA 3FMQA 2V3ZA 3MR1A 2GZ5A 4EGEA 3PKAA 3IU8A 2BWUA 1QXZA 2ZSGA 4IECA 1JAWA
chains in the Genus database with same CATH topology
2V6CA 3MX6A 3CB5A 4U6ZA 5D6FA 4PNCA 2BN7A 4U70A 4S2TP 4Z7MA 3PKBA 2DFIA 1XGSA 4MATA 2BWXA 1R58A 4RGZ1 1WN1A 2GG8A 2B3LA 2Q8KA 2GG5A 2GG7A 3IU7A 4U6EA 4U75A 5D6EA 1YW9A 5CDLA 1QXYA 1WBQA 3L7GA 2BHAA 1YJ3A 1BN5A 2B3KA 2GGBA 2GU6A 4U6CA 4B28A 1XGOA 4U6WA 4FLKA 1N51A 3TB5A 3IU9A 2EVMA 2EVOA 1B59A 4U69A 1CHMA 4QR8A 4S01A 2GGCA 1KQ0A 1YW8A 3BIPA 5FCHA 1C23A 3BITA 4S2RP 4FLLA 2OKNA 1Y1NA 2BWSA 2Q94A 1MATA 1YW7A 4RZYA 2BHDA 4U73A 2BWVA 4KM3A 4FUKA 2IW2A 2GG9A 4ZNGA 5FCFA 3FMRA 4U6JA 3D27A 4FKCA 1YVMA 1XGNA 1WKMA 3RVAA 2B3HA 3BIQA 5CIKA 4A6VA 1O0XA 4RZZA 4S00A 4IKRA 2P98A 1R5HA 3S6BA 2BWYA 4FLJA 1C22A 1PV9A 4IPAA 2BWWA 1A16A 5CLSA 2ADUA 4R60A 1C24A 3PKEA 5CE6A 1KP0A 1WLRA 1W2MA 1QXWA 2EA4A 4IKTA 4U1BA 1M35A 1C27A 2BB7A 1C21A 2BWTA 2GU5A 2MATA 2NQ7A 4FO8A 2G6PA 4IU6A 4IDYA 2V3YA 2Q96A 1W7VA 5JI6A 4U76A 3CTZA 4IF7A 4OOKA 1KQ9A 4IKUA 4IKSA 2Q95A 1BOAA 2Q92A 1WL9A 2Q93A 5CDEA 2BHCA 2GG3A 3Q6DA 1WY2A 5JFRA 4PV4A 1WL6A 2BHBA 2HOWA 2P9AA 2GG0A 1QZYA 2GA2A 2V3XA 5E5BA 3PKDA 4ZWOA 4ZWPA 4ZWUA 4FLIA 1B6AA 2EA2A 2GG2A 2BH3A 2NQ6A 5JHUA 2GU4A 3FM3A 3TAVA 1XGMA 3MATA 2EVCA 2GTXA 2P99A 3CB6A 3PKCA 4HXXA 4U71A 1R5GA 3L24A 5CNXA 2GU7A 4JUQA 3IG4A 2OAZA 5CDVA 1XNZA 3RORA 4FO7A 4A6WA 3FMQA 2V3ZA 3MR1A 2GZ5A 4EGEA 3PKAA 3IU8A 2BWUA 1QXZA 2ZSGA 4IECA 1JAWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2V6C A;  3MX6 A;  3CB5 A;  4U6Z A;  5D6F A;  4PNC A;  2BN7 A;  4U70 A;  4S2T P;  4Z7M A;  3PKB A;  2DFI A;  1XGS A;  4MAT A;  2BWX A;  1R58 A;  4RGZ 1;  1WN1 A;  2GG8 A;  2B3L A;  2Q8K A;  2GG5 A;  2GG7 A;  3IU7 A;  4U6E A;  4U75 A;  5D6E A;  1YW9 A;  5CDL A;  1QXY A;  1WBQ A;  3L7G A;  2BHA A;  1YJ3 A;  1BN5 A;  2B3K A;  2GGB A;  2GU6 A;  4U6C A;  4B28 A;  1XGO A;  4U6W A;  4FLK A;  1N51 A;  3TB5 A;  3IU9 A;  2EVM A;  2EVO A;  1B59 A;  4U69 A;  1CHM A;  4QR8 A;  4S01 A;  2GGC A;  1KQ0 A;  1YW8 A;  3BIP A;  5FCH A;  1C23 A;  3BIT A;  4S2R P;  4FLL A;  2OKN A;  1Y1N A;  2BWS A;  2Q94 A;  1MAT A;  1YW7 A;  4RZY A;  2BHD A;  4U73 A;  2BWV A;  4KM3 A;  4FUK A;  2IW2 A;  2GG9 A;  4ZNG A;  5FCF A;  3FMR A;  4U6J A;  3D27 A;  4FKC A;  1YVM A;  1XGN A;  1WKM A;  3RVA A;  2B3H A;  3BIQ A;  5CIK A;  4A6V A;  1O0X A;  4RZZ A;  4S00 A;  4IKR A;  2P98 A;  1R5H A;  3S6B A;  2BWY A;  4FLJ A;  1C22 A;  1PV9 A;  4IPA A;  2BWW A;  1A16 A;  5CLS A;  2ADU A;  4R60 A;  1C24 A;  3PKE A;  5CE6 A;  1KP0 A;  1WLR A;  1W2M A;  1QXW A;  2EA4 A;  4IKT A;  4U1B A;  1M35 A;  1C27 A;  2BB7 A;  1C21 A;  2BWT A;  2GU5 A;  2MAT A;  2NQ7 A;  4FO8 A;  2G6P A;  4IU6 A;  4IDY A;  2V3Y A;  2Q96 A;  1W7V A;  5JI6 A;  4U76 A;  3CTZ A;  4IF7 A;  4OOK A;  1KQ9 A;  4IKU A;  4IKS A;  2Q95 A;  1BOA A;  2Q92 A;  1WL9 A;  2Q93 A;  5CDE A;  2BHC A;  2GG3 A;  3Q6D A;  1WY2 A;  5JFR A;  4PV4 A;  1WL6 A;  2BHB A;  2HOW A;  2P9A A;  2GG0 A;  1QZY A;  2GA2 A;  2V3X A;  5E5B A;  3PKD A;  4ZWO A;  4ZWP A;  4ZWU A;  4FLI A;  1B6A A;  2EA2 A;  2GG2 A;  2BH3 A;  2NQ6 A;  5JHU A;  2GU4 A;  3FM3 A;  3TAV A;  1XGM A;  3MAT A;  2EVC A;  2GTX A;  2P99 A;  3CB6 A;  3PKC A;  4HXX A;  4U71 A;  1R5G A;  3L24 A;  5CNX A;  2GU7 A;  4JUQ A;  3IG4 A;  2OAZ A;  5CDV A;  1XNZ A;  3ROR A;  4FO7 A;  4A6W A;  3FMQ A;  2V3Z A;  3MR1 A;  2GZ5 A;  4EGE A;  3PKA A;  3IU8 A;  2BWU A;  1QXZ A;  2ZSG A;  4IEC A;  1JAW A; 
#chains in the Genus database with same CATH topology
 2V6C A;  3MX6 A;  3CB5 A;  4U6Z A;  5D6F A;  4PNC A;  2BN7 A;  4U70 A;  4S2T P;  4Z7M A;  3PKB A;  2DFI A;  1XGS A;  4MAT A;  2BWX A;  1R58 A;  4RGZ 1;  1WN1 A;  2GG8 A;  2B3L A;  2Q8K A;  2GG5 A;  2GG7 A;  3IU7 A;  4U6E A;  4U75 A;  5D6E A;  1YW9 A;  5CDL A;  1QXY A;  1WBQ A;  3L7G A;  2BHA A;  1YJ3 A;  1BN5 A;  2B3K A;  2GGB A;  2GU6 A;  4U6C A;  4B28 A;  1XGO A;  4U6W A;  4FLK A;  1N51 A;  3TB5 A;  3IU9 A;  2EVM A;  2EVO A;  1B59 A;  4U69 A;  1CHM A;  4QR8 A;  4S01 A;  2GGC A;  1KQ0 A;  1YW8 A;  3BIP A;  5FCH A;  1C23 A;  3BIT A;  4S2R P;  4FLL A;  2OKN A;  1Y1N A;  2BWS A;  2Q94 A;  1MAT A;  1YW7 A;  4RZY A;  2BHD A;  4U73 A;  2BWV A;  4KM3 A;  4FUK A;  2IW2 A;  2GG9 A;  4ZNG A;  5FCF A;  3FMR A;  4U6J A;  3D27 A;  4FKC A;  1YVM A;  1XGN A;  1WKM A;  3RVA A;  2B3H A;  3BIQ A;  5CIK A;  4A6V A;  1O0X A;  4RZZ A;  4S00 A;  4IKR A;  2P98 A;  1R5H A;  3S6B A;  2BWY A;  4FLJ A;  1C22 A;  1PV9 A;  4IPA A;  2BWW A;  1A16 A;  5CLS A;  2ADU A;  4R60 A;  1C24 A;  3PKE A;  5CE6 A;  1KP0 A;  1WLR A;  1W2M A;  1QXW A;  2EA4 A;  4IKT A;  4U1B A;  1M35 A;  1C27 A;  2BB7 A;  1C21 A;  2BWT A;  2GU5 A;  2MAT A;  2NQ7 A;  4FO8 A;  2G6P A;  4IU6 A;  4IDY A;  2V3Y A;  2Q96 A;  1W7V A;  5JI6 A;  4U76 A;  3CTZ A;  4IF7 A;  4OOK A;  1KQ9 A;  4IKU A;  4IKS A;  2Q95 A;  1BOA A;  2Q92 A;  1WL9 A;  2Q93 A;  5CDE A;  2BHC A;  2GG3 A;  3Q6D A;  1WY2 A;  5JFR A;  4PV4 A;  1WL6 A;  2BHB A;  2HOW A;  2P9A A;  2GG0 A;  1QZY A;  2GA2 A;  2V3X A;  5E5B A;  3PKD A;  4ZWO A;  4ZWP A;  4ZWU A;  4FLI A;  1B6A A;  2EA2 A;  2GG2 A;  2BH3 A;  2NQ6 A;  5JHU A;  2GU4 A;  3FM3 A;  3TAV A;  1XGM A;  3MAT A;  2EVC A;  2GTX A;  2P99 A;  3CB6 A;  3PKC A;  4HXX A;  4U71 A;  1R5G A;  3L24 A;  5CNX A;  2GU7 A;  4JUQ A;  3IG4 A;  2OAZ A;  5CDV A;  1XNZ A;  3ROR A;  4FO7 A;  4A6W A;  3FMQ A;  2V3Z A;  3MR1 A;  2GZ5 A;  4EGE A;  3PKA A;  3IU8 A;  2BWU A;  1QXZ A;  2ZSG A;  4IEC A;  1JAW A; 
#chains in the Genus database with same CATH homology
 2V6C A;  3MX6 A;  3CB5 A;  4U6Z A;  5D6F A;  4PNC A;  2BN7 A;  4U70 A;  4S2T P;  4Z7M A;  3PKB A;  2DFI A;  1XGS A;  4MAT A;  2BWX A;  1R58 A;  4RGZ 1;  1WN1 A;  2GG8 A;  2B3L A;  2Q8K A;  2GG5 A;  2GG7 A;  3IU7 A;  4U6E A;  4U75 A;  5D6E A;  1YW9 A;  5CDL A;  1QXY A;  1WBQ A;  3L7G A;  2BHA A;  1YJ3 A;  1BN5 A;  2B3K A;  2GGB A;  2GU6 A;  4U6C A;  4B28 A;  1XGO A;  4U6W A;  4FLK A;  1N51 A;  3TB5 A;  3IU9 A;  2EVM A;  2EVO A;  1B59 A;  4U69 A;  1CHM A;  4QR8 A;  4S01 A;  2GGC A;  1KQ0 A;  1YW8 A;  3BIP A;  5FCH A;  1C23 A;  3BIT A;  4S2R P;  4FLL A;  2OKN A;  1Y1N A;  2BWS A;  2Q94 A;  1MAT A;  1YW7 A;  4RZY A;  2BHD A;  4U73 A;  2BWV A;  4KM3 A;  4FUK A;  2IW2 A;  2GG9 A;  4ZNG A;  5FCF A;  3FMR A;  4U6J A;  3D27 A;  4FKC A;  1YVM A;  1XGN A;  1WKM A;  3RVA A;  2B3H A;  3BIQ A;  5CIK A;  4A6V A;  1O0X A;  4RZZ A;  4S00 A;  4IKR A;  2P98 A;  1R5H A;  3S6B A;  2BWY A;  4FLJ A;  1C22 A;  1PV9 A;  4IPA A;  2BWW A;  1A16 A;  5CLS A;  2ADU A;  4R60 A;  1C24 A;  3PKE A;  5CE6 A;  1KP0 A;  1WLR A;  1W2M A;  1QXW A;  2EA4 A;  4IKT A;  4U1B A;  1M35 A;  1C27 A;  2BB7 A;  1C21 A;  2BWT A;  2GU5 A;  2MAT A;  2NQ7 A;  4FO8 A;  2G6P A;  4IU6 A;  4IDY A;  2V3Y A;  2Q96 A;  1W7V A;  5JI6 A;  4U76 A;  3CTZ A;  4IF7 A;  4OOK A;  1KQ9 A;  4IKU A;  4IKS A;  2Q95 A;  1BOA A;  2Q92 A;  1WL9 A;  2Q93 A;  5CDE A;  2BHC A;  2GG3 A;  3Q6D A;  1WY2 A;  5JFR A;  4PV4 A;  1WL6 A;  2BHB A;  2HOW A;  2P9A A;  2GG0 A;  1QZY A;  2GA2 A;  2V3X A;  5E5B A;  3PKD A;  4ZWO A;  4ZWP A;  4ZWU A;  4FLI A;  1B6A A;  2EA2 A;  2GG2 A;  2BH3 A;  2NQ6 A;  5JHU A;  2GU4 A;  3FM3 A;  3TAV A;  1XGM A;  3MAT A;  2EVC A;  2GTX A;  2P99 A;  3CB6 A;  3PKC A;  4HXX A;  4U71 A;  1R5G A;  3L24 A;  5CNX A;  2GU7 A;  4JUQ A;  3IG4 A;  2OAZ A;  5CDV A;  1XNZ A;  3ROR A;  4FO7 A;  4A6W A;  3FMQ A;  2V3Z A;  3MR1 A;  2GZ5 A;  4EGE A;  3PKA A;  3IU8 A;  2BWU A;  1QXZ A;  2ZSG A;  4IEC A;  1JAW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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