4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
1N51A 3TB5A 2HOWA 1Y1NA 1B6AA 3FMQA 4PNCA 2OAZA 1C21A 1MATA 3PKBA 2BWVA 5CIKA 2GA2A 2BHAA 4U6CA 2GG7A 1KQ9A 2Q95A 3S6BA 4A6VA 2OKNA 3D27A 1KQ0A 5CDLA 2Q94A 1XGOA 2ADUA 1QXWA 1WLRA 2GZ5A 5FCFA 2V3ZA 4U70A 4B28A 2BWXA 4S01A 3IU9A 1C27A 1B59A 1BN5A 3CB6A 4MATA 4S2RP 2B3LA 2GG2A 3BITA 1YW8A 5E5BA 4Z7MA 4FO8A 4S2TP 2GG8A 3MR1A 4FO7A 3IU7A 4EGEA 2EVCA 4U75A 4KM3A 1C22A 1WKMA 4RZYA 4JUQA 2V3YA 1W7VA 4FLLA 1YJ3A 3MATA 1C24A 4FLIA 2GU7A 4FKCA 3MX6A 3RORA 2ZSGA 2GTXA 2GG5A 2BH3A 4FLJA 5CDEA 1YVMA 3L24A 1R58A 4RGZ1 2Q92A 2GGCA 4ZWOA 2Q93A 2B3HA 1PV9A 3L7GA 2NQ7A 3BIQA 4IKRA 5JI6A 2BB7A 5FCHA 1WY2A 5CDVA 1XGMA 2GG0A 4U69A 1KP0A 2DFIA 4IF7A 4OOKA 4U6JA 1XGNA 4IKUA 1W2MA 3PKDA 2B3KA 4HXXA 2MATA 1YW7A 5CLSA 3PKAA 2BHCA 2BWWA 3Q6DA 4IU6A 2P98A 4RZZA 3CB5A 2NQ6A 1CHMA 2BWYA 4S00A 4ZWUA 1C23A 2G6PA 1XGSA 1QXYA 4U6WA 5D6FA 5CE6A 4U6EA 1O0XA 3RVAA 5CNXA 4U73A 4IECA 4IKSA 4QR8A 1R5HA 1XNZA 4IKTA 4U1BA 2Q96A 4ZWPA 1WBQA 4IPAA 4FUKA 2GG3A 2EA2A 4ZNGA 2GG9A 2BHDA 5D6EA 1WL9A 2GGBA 4PV4A 2GU4A 1JAWA 2BHBA 1YW9A 3CTZA 3IG4A 1R5GA 1QXZA 1M35A 2Q8KA 4FLKA 2BWUA 2P9AA 1QZYA 1A16A 4IDYA 4U71A 2IW2A 3IU8A 3PKEA 3FM3A 2BWSA 5JFRA 2EA4A 3PKCA 3TAVA 5JHUA 1WL6A 2V3XA 2GU6A 1WN1A 2P99A 4U6ZA 2GU5A 2EVOA 4A6WA 2BN7A 3BIPA 4R60A 3FMRA 2BWTA 4U76A 1BOAA 2V6CA 2EVMA
chains in the Genus database with same CATH superfamily
1N51A 3TB5A 2HOWA 1Y1NA 1B6AA 3FMQA 4PNCA 2OAZA 1C21A 1MATA 3PKBA 2BWVA 5CIKA 2GA2A 2BHAA 4U6CA 2GG7A 1KQ9A 2Q95A 3S6BA 4A6VA 2OKNA 3D27A 1KQ0A 5CDLA 2Q94A 1XGOA 2ADUA 1QXWA 1WLRA 2GZ5A 5FCFA 2V3ZA 4U70A 4B28A 2BWXA 4S01A 3IU9A 1C27A 1B59A 1BN5A 3CB6A 4MATA 4S2RP 2B3LA 2GG2A 3BITA 1YW8A 5E5BA 4Z7MA 4FO8A 4S2TP 2GG8A 3MR1A 4FO7A 3IU7A 4EGEA 2EVCA 4U75A 4KM3A 1C22A 1WKMA 4RZYA 4JUQA 2V3YA 1W7VA 4FLLA 1YJ3A 3MATA 1C24A 4FLIA 2GU7A 4FKCA 3MX6A 3RORA 2ZSGA 2GTXA 2GG5A 2BH3A 4FLJA 5CDEA 1YVMA 3L24A 1R58A 4RGZ1 2Q92A 2GGCA 4ZWOA 2Q93A 2B3HA 1PV9A 3L7GA 2NQ7A 3BIQA 4IKRA 5JI6A 2BB7A 5FCHA 1WY2A 5CDVA 1XGMA 2GG0A 4U69A 1KP0A 2DFIA 4IF7A 4OOKA 4U6JA 1XGNA 4IKUA 1W2MA 3PKDA 2B3KA 4HXXA 2MATA 1YW7A 5CLSA 3PKAA 2BHCA 2BWWA 3Q6DA 4IU6A 2P98A 4RZZA 3CB5A 2NQ6A 1CHMA 2BWYA 4S00A 4ZWUA 1C23A 2G6PA 1XGSA 1QXYA 4U6WA 5D6FA 5CE6A 4U6EA 1O0XA 3RVAA 5CNXA 4U73A 4IECA 4IKSA 4QR8A 1R5HA 1XNZA 4IKTA 4U1BA 2Q96A 4ZWPA 1WBQA 4IPAA 4FUKA 2GG3A 2EA2A 4ZNGA 2GG9A 2BHDA 5D6EA 1WL9A 2GGBA 4PV4A 2GU4A 1JAWA 2BHBA 1YW9A 3CTZA 3IG4A 1R5GA 1QXZA 1M35A 2Q8KA 4FLKA 2BWUA 2P9AA 1QZYA 1A16A 4IDYA 4U71A 2IW2A 3IU8A 3PKEA 3FM3A 2BWSA 5JFRA 2EA4A 3PKCA 3TAVA 5JHUA 1WL6A 2V3XA 2GU6A 1WN1A 2P99A 4U6ZA 2GU5A 2EVOA 4A6WA 2BN7A 3BIPA 4R60A 3FMRA 2BWTA 4U76A 1BOAA 2V6CA 2EVMA
chains in the Genus database with same CATH topology
1N51A 3TB5A 2HOWA 1Y1NA 1B6AA 3FMQA 4PNCA 2OAZA 1C21A 1MATA 3PKBA 2BWVA 5CIKA 2GA2A 2BHAA 4U6CA 2GG7A 1KQ9A 2Q95A 3S6BA 4A6VA 2OKNA 3D27A 1KQ0A 5CDLA 2Q94A 1XGOA 2ADUA 1QXWA 1WLRA 2GZ5A 5FCFA 2V3ZA 4U70A 4B28A 2BWXA 4S01A 3IU9A 1C27A 1B59A 1BN5A 3CB6A 4MATA 4S2RP 2B3LA 2GG2A 3BITA 1YW8A 5E5BA 4Z7MA 4FO8A 4S2TP 2GG8A 3MR1A 4FO7A 3IU7A 4EGEA 2EVCA 4U75A 4KM3A 1C22A 1WKMA 4RZYA 4JUQA 2V3YA 1W7VA 4FLLA 1YJ3A 3MATA 1C24A 4FLIA 2GU7A 4FKCA 3MX6A 3RORA 2ZSGA 2GTXA 2GG5A 2BH3A 4FLJA 5CDEA 1YVMA 3L24A 1R58A 4RGZ1 2Q92A 2GGCA 4ZWOA 2Q93A 2B3HA 1PV9A 3L7GA 2NQ7A 3BIQA 4IKRA 5JI6A 2BB7A 5FCHA 1WY2A 5CDVA 1XGMA 2GG0A 4U69A 1KP0A 2DFIA 4IF7A 4OOKA 4U6JA 1XGNA 4IKUA 1W2MA 3PKDA 2B3KA 4HXXA 2MATA 1YW7A 5CLSA 3PKAA 2BHCA 2BWWA 3Q6DA 4IU6A 2P98A 4RZZA 3CB5A 2NQ6A 1CHMA 2BWYA 4S00A 4ZWUA 1C23A 2G6PA 1XGSA 1QXYA 4U6WA 5D6FA 5CE6A 4U6EA 1O0XA 3RVAA 5CNXA 4U73A 4IECA 4IKSA 4QR8A 1R5HA 1XNZA 4IKTA 4U1BA 2Q96A 4ZWPA 1WBQA 4IPAA 4FUKA 2GG3A 2EA2A 4ZNGA 2GG9A 2BHDA 5D6EA 1WL9A 2GGBA 4PV4A 2GU4A 1JAWA 2BHBA 1YW9A 3CTZA 3IG4A 1R5GA 1QXZA 1M35A 2Q8KA 4FLKA 2BWUA 2P9AA 1QZYA 1A16A 4IDYA 4U71A 2IW2A 3IU8A 3PKEA 3FM3A 2BWSA 5JFRA 2EA4A 3PKCA 3TAVA 5JHUA 1WL6A 2V3XA 2GU6A 1WN1A 2P99A 4U6ZA 2GU5A 2EVOA 4A6WA 2BN7A 3BIPA 4R60A 3FMRA 2BWTA 4U76A 1BOAA 2V6CA 2EVMA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1N51 A;  3TB5 A;  2HOW A;  1Y1N A;  1B6A A;  3FMQ A;  4PNC A;  2OAZ A;  1C21 A;  1MAT A;  3PKB A;  2BWV A;  5CIK A;  2GA2 A;  2BHA A;  4U6C A;  2GG7 A;  1KQ9 A;  2Q95 A;  3S6B A;  4A6V A;  2OKN A;  3D27 A;  1KQ0 A;  5CDL A;  2Q94 A;  1XGO A;  2ADU A;  1QXW A;  1WLR A;  2GZ5 A;  5FCF A;  2V3Z A;  4U70 A;  4B28 A;  2BWX A;  4S01 A;  3IU9 A;  1C27 A;  1B59 A;  1BN5 A;  3CB6 A;  4MAT A;  4S2R P;  2B3L A;  2GG2 A;  3BIT A;  1YW8 A;  5E5B A;  4Z7M A;  4FO8 A;  4S2T P;  2GG8 A;  3MR1 A;  4FO7 A;  3IU7 A;  4EGE A;  2EVC A;  4U75 A;  4KM3 A;  1C22 A;  1WKM A;  4RZY A;  4JUQ A;  2V3Y A;  1W7V A;  4FLL A;  1YJ3 A;  3MAT A;  1C24 A;  4FLI A;  2GU7 A;  4FKC A;  3MX6 A;  3ROR A;  2ZSG A;  2GTX A;  2GG5 A;  2BH3 A;  4FLJ A;  5CDE A;  1YVM A;  3L24 A;  1R58 A;  4RGZ 1;  2Q92 A;  2GGC A;  4ZWO A;  2Q93 A;  2B3H A;  1PV9 A;  3L7G A;  2NQ7 A;  3BIQ A;  4IKR A;  5JI6 A;  2BB7 A;  5FCH A;  1WY2 A;  5CDV A;  1XGM A;  2GG0 A;  4U69 A;  1KP0 A;  2DFI A;  4IF7 A;  4OOK A;  4U6J A;  1XGN A;  4IKU A;  1W2M A;  3PKD A;  2B3K A;  4HXX A;  2MAT A;  1YW7 A;  5CLS A;  3PKA A;  2BHC A;  2BWW A;  3Q6D A;  4IU6 A;  2P98 A;  4RZZ A;  3CB5 A;  2NQ6 A;  1CHM A;  2BWY A;  4S00 A;  4ZWU A;  1C23 A;  2G6P A;  1XGS A;  1QXY A;  4U6W A;  5D6F A;  5CE6 A;  4U6E A;  1O0X A;  3RVA A;  5CNX A;  4U73 A;  4IEC A;  4IKS A;  4QR8 A;  1R5H A;  1XNZ A;  4IKT A;  4U1B A;  2Q96 A;  4ZWP A;  1WBQ A;  4IPA A;  4FUK A;  2GG3 A;  2EA2 A;  4ZNG A;  2GG9 A;  2BHD A;  5D6E A;  1WL9 A;  2GGB A;  4PV4 A;  2GU4 A;  1JAW A;  2BHB A;  1YW9 A;  3CTZ A;  3IG4 A;  1R5G A;  1QXZ A;  1M35 A;  2Q8K A;  4FLK A;  2BWU A;  2P9A A;  1QZY A;  1A16 A;  4IDY A;  4U71 A;  2IW2 A;  3IU8 A;  3PKE A;  3FM3 A;  2BWS A;  5JFR A;  2EA4 A;  3PKC A;  3TAV A;  5JHU A;  1WL6 A;  2V3X A;  2GU6 A;  1WN1 A;  2P99 A;  4U6Z A;  2GU5 A;  2EVO A;  4A6W A;  2BN7 A;  3BIP A;  4R60 A;  3FMR A;  2BWT A;  4U76 A;  1BOA A;  2V6C A;  2EVM A; 
#chains in the Genus database with same CATH topology
 1N51 A;  3TB5 A;  2HOW A;  1Y1N A;  1B6A A;  3FMQ A;  4PNC A;  2OAZ A;  1C21 A;  1MAT A;  3PKB A;  2BWV A;  5CIK A;  2GA2 A;  2BHA A;  4U6C A;  2GG7 A;  1KQ9 A;  2Q95 A;  3S6B A;  4A6V A;  2OKN A;  3D27 A;  1KQ0 A;  5CDL A;  2Q94 A;  1XGO A;  2ADU A;  1QXW A;  1WLR A;  2GZ5 A;  5FCF A;  2V3Z A;  4U70 A;  4B28 A;  2BWX A;  4S01 A;  3IU9 A;  1C27 A;  1B59 A;  1BN5 A;  3CB6 A;  4MAT A;  4S2R P;  2B3L A;  2GG2 A;  3BIT A;  1YW8 A;  5E5B A;  4Z7M A;  4FO8 A;  4S2T P;  2GG8 A;  3MR1 A;  4FO7 A;  3IU7 A;  4EGE A;  2EVC A;  4U75 A;  4KM3 A;  1C22 A;  1WKM A;  4RZY A;  4JUQ A;  2V3Y A;  1W7V A;  4FLL A;  1YJ3 A;  3MAT A;  1C24 A;  4FLI A;  2GU7 A;  4FKC A;  3MX6 A;  3ROR A;  2ZSG A;  2GTX A;  2GG5 A;  2BH3 A;  4FLJ A;  5CDE A;  1YVM A;  3L24 A;  1R58 A;  4RGZ 1;  2Q92 A;  2GGC A;  4ZWO A;  2Q93 A;  2B3H A;  1PV9 A;  3L7G A;  2NQ7 A;  3BIQ A;  4IKR A;  5JI6 A;  2BB7 A;  5FCH A;  1WY2 A;  5CDV A;  1XGM A;  2GG0 A;  4U69 A;  1KP0 A;  2DFI A;  4IF7 A;  4OOK A;  4U6J A;  1XGN A;  4IKU A;  1W2M A;  3PKD A;  2B3K A;  4HXX A;  2MAT A;  1YW7 A;  5CLS A;  3PKA A;  2BHC A;  2BWW A;  3Q6D A;  4IU6 A;  2P98 A;  4RZZ A;  3CB5 A;  2NQ6 A;  1CHM A;  2BWY A;  4S00 A;  4ZWU A;  1C23 A;  2G6P A;  1XGS A;  1QXY A;  4U6W A;  5D6F A;  5CE6 A;  4U6E A;  1O0X A;  3RVA A;  5CNX A;  4U73 A;  4IEC A;  4IKS A;  4QR8 A;  1R5H A;  1XNZ A;  4IKT A;  4U1B A;  2Q96 A;  4ZWP A;  1WBQ A;  4IPA A;  4FUK A;  2GG3 A;  2EA2 A;  4ZNG A;  2GG9 A;  2BHD A;  5D6E A;  1WL9 A;  2GGB A;  4PV4 A;  2GU4 A;  1JAW A;  2BHB A;  1YW9 A;  3CTZ A;  3IG4 A;  1R5G A;  1QXZ A;  1M35 A;  2Q8K A;  4FLK A;  2BWU A;  2P9A A;  1QZY A;  1A16 A;  4IDY A;  4U71 A;  2IW2 A;  3IU8 A;  3PKE A;  3FM3 A;  2BWS A;  5JFR A;  2EA4 A;  3PKC A;  3TAV A;  5JHU A;  1WL6 A;  2V3X A;  2GU6 A;  1WN1 A;  2P99 A;  4U6Z A;  2GU5 A;  2EVO A;  4A6W A;  2BN7 A;  3BIP A;  4R60 A;  3FMR A;  2BWT A;  4U76 A;  1BOA A;  2V6C A;  2EVM A; 
#chains in the Genus database with same CATH homology
 1N51 A;  3TB5 A;  2HOW A;  1Y1N A;  1B6A A;  3FMQ A;  4PNC A;  2OAZ A;  1C21 A;  1MAT A;  3PKB A;  2BWV A;  5CIK A;  2GA2 A;  2BHA A;  4U6C A;  2GG7 A;  1KQ9 A;  2Q95 A;  3S6B A;  4A6V A;  2OKN A;  3D27 A;  1KQ0 A;  5CDL A;  2Q94 A;  1XGO A;  2ADU A;  1QXW A;  1WLR A;  2GZ5 A;  5FCF A;  2V3Z A;  4U70 A;  4B28 A;  2BWX A;  4S01 A;  3IU9 A;  1C27 A;  1B59 A;  1BN5 A;  3CB6 A;  4MAT A;  4S2R P;  2B3L A;  2GG2 A;  3BIT A;  1YW8 A;  5E5B A;  4Z7M A;  4FO8 A;  4S2T P;  2GG8 A;  3MR1 A;  4FO7 A;  3IU7 A;  4EGE A;  2EVC A;  4U75 A;  4KM3 A;  1C22 A;  1WKM A;  4RZY A;  4JUQ A;  2V3Y A;  1W7V A;  4FLL A;  1YJ3 A;  3MAT A;  1C24 A;  4FLI A;  2GU7 A;  4FKC A;  3MX6 A;  3ROR A;  2ZSG A;  2GTX A;  2GG5 A;  2BH3 A;  4FLJ A;  5CDE A;  1YVM A;  3L24 A;  1R58 A;  4RGZ 1;  2Q92 A;  2GGC A;  4ZWO A;  2Q93 A;  2B3H A;  1PV9 A;  3L7G A;  2NQ7 A;  3BIQ A;  4IKR A;  5JI6 A;  2BB7 A;  5FCH A;  1WY2 A;  5CDV A;  1XGM A;  2GG0 A;  4U69 A;  1KP0 A;  2DFI A;  4IF7 A;  4OOK A;  4U6J A;  1XGN A;  4IKU A;  1W2M A;  3PKD A;  2B3K A;  4HXX A;  2MAT A;  1YW7 A;  5CLS A;  3PKA A;  2BHC A;  2BWW A;  3Q6D A;  4IU6 A;  2P98 A;  4RZZ A;  3CB5 A;  2NQ6 A;  1CHM A;  2BWY A;  4S00 A;  4ZWU A;  1C23 A;  2G6P A;  1XGS A;  1QXY A;  4U6W A;  5D6F A;  5CE6 A;  4U6E A;  1O0X A;  3RVA A;  5CNX A;  4U73 A;  4IEC A;  4IKS A;  4QR8 A;  1R5H A;  1XNZ A;  4IKT A;  4U1B A;  2Q96 A;  4ZWP A;  1WBQ A;  4IPA A;  4FUK A;  2GG3 A;  2EA2 A;  4ZNG A;  2GG9 A;  2BHD A;  5D6E A;  1WL9 A;  2GGB A;  4PV4 A;  2GU4 A;  1JAW A;  2BHB A;  1YW9 A;  3CTZ A;  3IG4 A;  1R5G A;  1QXZ A;  1M35 A;  2Q8K A;  4FLK A;  2BWU A;  2P9A A;  1QZY A;  1A16 A;  4IDY A;  4U71 A;  2IW2 A;  3IU8 A;  3PKE A;  3FM3 A;  2BWS A;  5JFR A;  2EA4 A;  3PKC A;  3TAV A;  5JHU A;  1WL6 A;  2V3X A;  2GU6 A;  1WN1 A;  2P99 A;  4U6Z A;  2GU5 A;  2EVO A;  4A6W A;  2BN7 A;  3BIP A;  4R60 A;  3FMR A;  2BWT A;  4U76 A;  1BOA A;  2V6C A;  2EVM A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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