4U6JA

Hsmetap in complex with methionine
Total Genus 102
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
102
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 102
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-29

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u6jA00
1O0XA 5E5BA 2V3XA 4ZWUA 1R5HA 3PKBA 3CB6A 4MATA 3FMQA 4U6JA 2EVOA 2ZSGA 3PKDA 2GG3A 2Q92A 2V3ZA 2DFIA 1YJ3A 4FLIA 2B3LA 2BWXA 3BITA 1XNZA 4IKTA 2NQ6A 4U6EA 4U76A 2P99A 2BHDA 2BH3A 2ADUA 1YW7A 1C23A 2GU6A 1KP0A 4FO8A 4IPAA 4FLJA 1YVMA 3IU9A 1WN1A 2BHBA 2BWWA 3BIPA 1WL6A 2BHCA 5CNXA 3CTZA 4S00A 4U69A 4FLLA 4U1BA 2GG5A 2BWYA 4ZNGA 3D27A 4FO7A 4JUQA 4U70A 1BOAA 4IDYA 2BWUA 2G6PA 2EVCA 3IU7A 1WY2A 3CB5A 1MATA 5D6EA 1BN5A 4S01A 2BWVA 2OKNA 3MATA 1YW9A 2EA2A 2BWTA 1XGMA 1PV9A 3L24A 2EVMA 5JI6A 1C24A 5FCHA 2BWSA 3FMRA 4OOKA 5FCFA 2GZ5A 2EA4A 1C22A 3PKEA 2Q94A 4HXXA 3IG4A 4FUKA 4S2RP 3MX6A 3IU8A 5CIKA 1QXZA 3RVAA 2Q96A 1M35A 1QXYA 3Q6DA 2GG8A 2GTXA 1KQ9A 4ZWPA 1A16A 1XGSA 1KQ0A 2BN7A 2HOWA 2P9AA 2IW2A 4KM3A 1YW8A 3BIQA 4IKSA 4RZZA 2GG2A 2NQ7A 1WL9A 4U6WA 4R60A 4A6VA 4U75A 5D6FA 4A6WA 1R5GA 1B59A 4IF7A 2GG7A 2GU4A 4PNCA 3S6BA 4FKCA 1B6AA 1QZYA 3RORA 4IKRA 4B28A 3PKAA 2V6CA 5CLSA 4RZYA 4U71A 4PV4A 4IU6A 2Q8KA 2MATA 5CDLA 4IECA 4U73A 1JAWA 2GA2A 1W7VA 2OAZA 2GGCA 1CHMA 1C21A 1XGNA 5JHUA 5CE6A 4IKUA 4Z7MA 2GGBA 1N51A 3TB5A 5CDVA 1WLRA 4EGEA 4FLKA 1W2MA 2GU7A 1R58A 4ZWOA 5JFRA 2P98A 2GG9A 1QXWA 1C27A 4U6CA 2GG0A 1XGOA 5CDEA 4U6ZA 3PKCA 2GU5A 2B3KA 2B3HA 4QR8A 3L7GA 1Y1NA 2Q95A 1WBQA 1WKMA 2BHAA 3TAVA 2Q93A 4S2TP 2V3YA 4RGZ1 2BB7A 3FM3A 3MR1A
chains in the Genus database with same CATH superfamily
1O0XA 5E5BA 2V3XA 4ZWUA 1R5HA 3PKBA 3CB6A 4MATA 3FMQA 4U6JA 2EVOA 2ZSGA 3PKDA 2GG3A 2Q92A 2V3ZA 2DFIA 1YJ3A 4FLIA 2B3LA 2BWXA 3BITA 1XNZA 4IKTA 2NQ6A 4U6EA 4U76A 2P99A 2BHDA 2BH3A 2ADUA 1YW7A 1C23A 2GU6A 1KP0A 4FO8A 4IPAA 4FLJA 1YVMA 3IU9A 1WN1A 2BHBA 2BWWA 3BIPA 1WL6A 2BHCA 5CNXA 3CTZA 4S00A 4U69A 4FLLA 4U1BA 2GG5A 2BWYA 4ZNGA 3D27A 4FO7A 4JUQA 4U70A 1BOAA 4IDYA 2BWUA 2G6PA 2EVCA 3IU7A 1WY2A 3CB5A 1MATA 5D6EA 1BN5A 4S01A 2BWVA 2OKNA 3MATA 1YW9A 2EA2A 2BWTA 1XGMA 1PV9A 3L24A 2EVMA 5JI6A 1C24A 5FCHA 2BWSA 3FMRA 4OOKA 5FCFA 2GZ5A 2EA4A 1C22A 3PKEA 2Q94A 4HXXA 3IG4A 4FUKA 4S2RP 3MX6A 3IU8A 5CIKA 1QXZA 3RVAA 2Q96A 1M35A 1QXYA 3Q6DA 2GG8A 2GTXA 1KQ9A 4ZWPA 1A16A 1XGSA 1KQ0A 2BN7A 2HOWA 2P9AA 2IW2A 4KM3A 1YW8A 3BIQA 4IKSA 4RZZA 2GG2A 2NQ7A 1WL9A 4U6WA 4R60A 4A6VA 4U75A 5D6FA 4A6WA 1R5GA 1B59A 4IF7A 2GG7A 2GU4A 4PNCA 3S6BA 4FKCA 1B6AA 1QZYA 3RORA 4IKRA 4B28A 3PKAA 2V6CA 5CLSA 4RZYA 4U71A 4PV4A 4IU6A 2Q8KA 2MATA 5CDLA 4IECA 4U73A 1JAWA 2GA2A 1W7VA 2OAZA 2GGCA 1CHMA 1C21A 1XGNA 5JHUA 5CE6A 4IKUA 4Z7MA 2GGBA 1N51A 3TB5A 5CDVA 1WLRA 4EGEA 4FLKA 1W2MA 2GU7A 1R58A 4ZWOA 5JFRA 2P98A 2GG9A 1QXWA 1C27A 4U6CA 2GG0A 1XGOA 5CDEA 4U6ZA 3PKCA 2GU5A 2B3KA 2B3HA 4QR8A 3L7GA 1Y1NA 2Q95A 1WBQA 1WKMA 2BHAA 3TAVA 2Q93A 4S2TP 2V3YA 4RGZ1 2BB7A 3FM3A 3MR1A
chains in the Genus database with same CATH topology
1O0XA 5E5BA 2V3XA 4ZWUA 1R5HA 3PKBA 3CB6A 4MATA 3FMQA 4U6JA 2EVOA 2ZSGA 3PKDA 2GG3A 2Q92A 2V3ZA 2DFIA 1YJ3A 4FLIA 2B3LA 2BWXA 3BITA 1XNZA 4IKTA 2NQ6A 4U6EA 4U76A 2P99A 2BHDA 2BH3A 2ADUA 1YW7A 1C23A 2GU6A 1KP0A 4FO8A 4IPAA 4FLJA 1YVMA 3IU9A 1WN1A 2BHBA 2BWWA 3BIPA 1WL6A 2BHCA 5CNXA 3CTZA 4S00A 4U69A 4FLLA 4U1BA 2GG5A 2BWYA 4ZNGA 3D27A 4FO7A 4JUQA 4U70A 1BOAA 4IDYA 2BWUA 2G6PA 2EVCA 3IU7A 1WY2A 3CB5A 1MATA 5D6EA 1BN5A 4S01A 2BWVA 2OKNA 3MATA 1YW9A 2EA2A 2BWTA 1XGMA 1PV9A 3L24A 2EVMA 5JI6A 1C24A 5FCHA 2BWSA 3FMRA 4OOKA 5FCFA 2GZ5A 2EA4A 1C22A 3PKEA 2Q94A 4HXXA 3IG4A 4FUKA 4S2RP 3MX6A 3IU8A 5CIKA 1QXZA 3RVAA 2Q96A 1M35A 1QXYA 3Q6DA 2GG8A 2GTXA 1KQ9A 4ZWPA 1A16A 1XGSA 1KQ0A 2BN7A 2HOWA 2P9AA 2IW2A 4KM3A 1YW8A 3BIQA 4IKSA 4RZZA 2GG2A 2NQ7A 1WL9A 4U6WA 4R60A 4A6VA 4U75A 5D6FA 4A6WA 1R5GA 1B59A 4IF7A 2GG7A 2GU4A 4PNCA 3S6BA 4FKCA 1B6AA 1QZYA 3RORA 4IKRA 4B28A 3PKAA 2V6CA 5CLSA 4RZYA 4U71A 4PV4A 4IU6A 2Q8KA 2MATA 5CDLA 4IECA 4U73A 1JAWA 2GA2A 1W7VA 2OAZA 2GGCA 1CHMA 1C21A 1XGNA 5JHUA 5CE6A 4IKUA 4Z7MA 2GGBA 1N51A 3TB5A 5CDVA 1WLRA 4EGEA 4FLKA 1W2MA 2GU7A 1R58A 4ZWOA 5JFRA 2P98A 2GG9A 1QXWA 1C27A 4U6CA 2GG0A 1XGOA 5CDEA 4U6ZA 3PKCA 2GU5A 2B3KA 2B3HA 4QR8A 3L7GA 1Y1NA 2Q95A 1WBQA 1WKMA 2BHAA 3TAVA 2Q93A 4S2TP 2V3YA 4RGZ1 2BB7A 3FM3A 3MR1A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1O0X A;  5E5B A;  2V3X A;  4ZWU A;  1R5H A;  3PKB A;  3CB6 A;  4MAT A;  3FMQ A;  4U6J A;  2EVO A;  2ZSG A;  3PKD A;  2GG3 A;  2Q92 A;  2V3Z A;  2DFI A;  1YJ3 A;  4FLI A;  2B3L A;  2BWX A;  3BIT A;  1XNZ A;  4IKT A;  2NQ6 A;  4U6E A;  4U76 A;  2P99 A;  2BHD A;  2BH3 A;  2ADU A;  1YW7 A;  1C23 A;  2GU6 A;  1KP0 A;  4FO8 A;  4IPA A;  4FLJ A;  1YVM A;  3IU9 A;  1WN1 A;  2BHB A;  2BWW A;  3BIP A;  1WL6 A;  2BHC A;  5CNX A;  3CTZ A;  4S00 A;  4U69 A;  4FLL A;  4U1B A;  2GG5 A;  2BWY A;  4ZNG A;  3D27 A;  4FO7 A;  4JUQ A;  4U70 A;  1BOA A;  4IDY A;  2BWU A;  2G6P A;  2EVC A;  3IU7 A;  1WY2 A;  3CB5 A;  1MAT A;  5D6E A;  1BN5 A;  4S01 A;  2BWV A;  2OKN A;  3MAT A;  1YW9 A;  2EA2 A;  2BWT A;  1XGM A;  1PV9 A;  3L24 A;  2EVM A;  5JI6 A;  1C24 A;  5FCH A;  2BWS A;  3FMR A;  4OOK A;  5FCF A;  2GZ5 A;  2EA4 A;  1C22 A;  3PKE A;  2Q94 A;  4HXX A;  3IG4 A;  4FUK A;  4S2R P;  3MX6 A;  3IU8 A;  5CIK A;  1QXZ A;  3RVA A;  2Q96 A;  1M35 A;  1QXY A;  3Q6D A;  2GG8 A;  2GTX A;  1KQ9 A;  4ZWP A;  1A16 A;  1XGS A;  1KQ0 A;  2BN7 A;  2HOW A;  2P9A A;  2IW2 A;  4KM3 A;  1YW8 A;  3BIQ A;  4IKS A;  4RZZ A;  2GG2 A;  2NQ7 A;  1WL9 A;  4U6W A;  4R60 A;  4A6V A;  4U75 A;  5D6F A;  4A6W A;  1R5G A;  1B59 A;  4IF7 A;  2GG7 A;  2GU4 A;  4PNC A;  3S6B A;  4FKC A;  1B6A A;  1QZY A;  3ROR A;  4IKR A;  4B28 A;  3PKA A;  2V6C A;  5CLS A;  4RZY A;  4U71 A;  4PV4 A;  4IU6 A;  2Q8K A;  2MAT A;  5CDL A;  4IEC A;  4U73 A;  1JAW A;  2GA2 A;  1W7V A;  2OAZ A;  2GGC A;  1CHM A;  1C21 A;  1XGN A;  5JHU A;  5CE6 A;  4IKU A;  4Z7M A;  2GGB A;  1N51 A;  3TB5 A;  5CDV A;  1WLR A;  4EGE A;  4FLK A;  1W2M A;  2GU7 A;  1R58 A;  4ZWO A;  5JFR A;  2P98 A;  2GG9 A;  1QXW A;  1C27 A;  4U6C A;  2GG0 A;  1XGO A;  5CDE A;  4U6Z A;  3PKC A;  2GU5 A;  2B3K A;  2B3H A;  4QR8 A;  3L7G A;  1Y1N A;  2Q95 A;  1WBQ A;  1WKM A;  2BHA A;  3TAV A;  2Q93 A;  4S2T P;  2V3Y A;  4RGZ 1;  2BB7 A;  3FM3 A;  3MR1 A; 
#chains in the Genus database with same CATH topology
 1O0X A;  5E5B A;  2V3X A;  4ZWU A;  1R5H A;  3PKB A;  3CB6 A;  4MAT A;  3FMQ A;  4U6J A;  2EVO A;  2ZSG A;  3PKD A;  2GG3 A;  2Q92 A;  2V3Z A;  2DFI A;  1YJ3 A;  4FLI A;  2B3L A;  2BWX A;  3BIT A;  1XNZ A;  4IKT A;  2NQ6 A;  4U6E A;  4U76 A;  2P99 A;  2BHD A;  2BH3 A;  2ADU A;  1YW7 A;  1C23 A;  2GU6 A;  1KP0 A;  4FO8 A;  4IPA A;  4FLJ A;  1YVM A;  3IU9 A;  1WN1 A;  2BHB A;  2BWW A;  3BIP A;  1WL6 A;  2BHC A;  5CNX A;  3CTZ A;  4S00 A;  4U69 A;  4FLL A;  4U1B A;  2GG5 A;  2BWY A;  4ZNG A;  3D27 A;  4FO7 A;  4JUQ A;  4U70 A;  1BOA A;  4IDY A;  2BWU A;  2G6P A;  2EVC A;  3IU7 A;  1WY2 A;  3CB5 A;  1MAT A;  5D6E A;  1BN5 A;  4S01 A;  2BWV A;  2OKN A;  3MAT A;  1YW9 A;  2EA2 A;  2BWT A;  1XGM A;  1PV9 A;  3L24 A;  2EVM A;  5JI6 A;  1C24 A;  5FCH A;  2BWS A;  3FMR A;  4OOK A;  5FCF A;  2GZ5 A;  2EA4 A;  1C22 A;  3PKE A;  2Q94 A;  4HXX A;  3IG4 A;  4FUK A;  4S2R P;  3MX6 A;  3IU8 A;  5CIK A;  1QXZ A;  3RVA A;  2Q96 A;  1M35 A;  1QXY A;  3Q6D A;  2GG8 A;  2GTX A;  1KQ9 A;  4ZWP A;  1A16 A;  1XGS A;  1KQ0 A;  2BN7 A;  2HOW A;  2P9A A;  2IW2 A;  4KM3 A;  1YW8 A;  3BIQ A;  4IKS A;  4RZZ A;  2GG2 A;  2NQ7 A;  1WL9 A;  4U6W A;  4R60 A;  4A6V A;  4U75 A;  5D6F A;  4A6W A;  1R5G A;  1B59 A;  4IF7 A;  2GG7 A;  2GU4 A;  4PNC A;  3S6B A;  4FKC A;  1B6A A;  1QZY A;  3ROR A;  4IKR A;  4B28 A;  3PKA A;  2V6C A;  5CLS A;  4RZY A;  4U71 A;  4PV4 A;  4IU6 A;  2Q8K A;  2MAT A;  5CDL A;  4IEC A;  4U73 A;  1JAW A;  2GA2 A;  1W7V A;  2OAZ A;  2GGC A;  1CHM A;  1C21 A;  1XGN A;  5JHU A;  5CE6 A;  4IKU A;  4Z7M A;  2GGB A;  1N51 A;  3TB5 A;  5CDV A;  1WLR A;  4EGE A;  4FLK A;  1W2M A;  2GU7 A;  1R58 A;  4ZWO A;  5JFR A;  2P98 A;  2GG9 A;  1QXW A;  1C27 A;  4U6C A;  2GG0 A;  1XGO A;  5CDE A;  4U6Z A;  3PKC A;  2GU5 A;  2B3K A;  2B3H A;  4QR8 A;  3L7G A;  1Y1N A;  2Q95 A;  1WBQ A;  1WKM A;  2BHA A;  3TAV A;  2Q93 A;  4S2T P;  2V3Y A;  4RGZ 1;  2BB7 A;  3FM3 A;  3MR1 A; 
#chains in the Genus database with same CATH homology
 1O0X A;  5E5B A;  2V3X A;  4ZWU A;  1R5H A;  3PKB A;  3CB6 A;  4MAT A;  3FMQ A;  4U6J A;  2EVO A;  2ZSG A;  3PKD A;  2GG3 A;  2Q92 A;  2V3Z A;  2DFI A;  1YJ3 A;  4FLI A;  2B3L A;  2BWX A;  3BIT A;  1XNZ A;  4IKT A;  2NQ6 A;  4U6E A;  4U76 A;  2P99 A;  2BHD A;  2BH3 A;  2ADU A;  1YW7 A;  1C23 A;  2GU6 A;  1KP0 A;  4FO8 A;  4IPA A;  4FLJ A;  1YVM A;  3IU9 A;  1WN1 A;  2BHB A;  2BWW A;  3BIP A;  1WL6 A;  2BHC A;  5CNX A;  3CTZ A;  4S00 A;  4U69 A;  4FLL A;  4U1B A;  2GG5 A;  2BWY A;  4ZNG A;  3D27 A;  4FO7 A;  4JUQ A;  4U70 A;  1BOA A;  4IDY A;  2BWU A;  2G6P A;  2EVC A;  3IU7 A;  1WY2 A;  3CB5 A;  1MAT A;  5D6E A;  1BN5 A;  4S01 A;  2BWV A;  2OKN A;  3MAT A;  1YW9 A;  2EA2 A;  2BWT A;  1XGM A;  1PV9 A;  3L24 A;  2EVM A;  5JI6 A;  1C24 A;  5FCH A;  2BWS A;  3FMR A;  4OOK A;  5FCF A;  2GZ5 A;  2EA4 A;  1C22 A;  3PKE A;  2Q94 A;  4HXX A;  3IG4 A;  4FUK A;  4S2R P;  3MX6 A;  3IU8 A;  5CIK A;  1QXZ A;  3RVA A;  2Q96 A;  1M35 A;  1QXY A;  3Q6D A;  2GG8 A;  2GTX A;  1KQ9 A;  4ZWP A;  1A16 A;  1XGS A;  1KQ0 A;  2BN7 A;  2HOW A;  2P9A A;  2IW2 A;  4KM3 A;  1YW8 A;  3BIQ A;  4IKS A;  4RZZ A;  2GG2 A;  2NQ7 A;  1WL9 A;  4U6W A;  4R60 A;  4A6V A;  4U75 A;  5D6F A;  4A6W A;  1R5G A;  1B59 A;  4IF7 A;  2GG7 A;  2GU4 A;  4PNC A;  3S6B A;  4FKC A;  1B6A A;  1QZY A;  3ROR A;  4IKR A;  4B28 A;  3PKA A;  2V6C A;  5CLS A;  4RZY A;  4U71 A;  4PV4 A;  4IU6 A;  2Q8K A;  2MAT A;  5CDL A;  4IEC A;  4U73 A;  1JAW A;  2GA2 A;  1W7V A;  2OAZ A;  2GGC A;  1CHM A;  1C21 A;  1XGN A;  5JHU A;  5CE6 A;  4IKU A;  4Z7M A;  2GGB A;  1N51 A;  3TB5 A;  5CDV A;  1WLR A;  4EGE A;  4FLK A;  1W2M A;  2GU7 A;  1R58 A;  4ZWO A;  5JFR A;  2P98 A;  2GG9 A;  1QXW A;  1C27 A;  4U6C A;  2GG0 A;  1XGO A;  5CDE A;  4U6Z A;  3PKC A;  2GU5 A;  2B3K A;  2B3H A;  4QR8 A;  3L7G A;  1Y1N A;  2Q95 A;  1WBQ A;  1WKM A;  2BHA A;  3TAV A;  2Q93 A;  4S2T P;  2V3Y A;  4RGZ 1;  2BB7 A;  3FM3 A;  3MR1 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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