4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
1WY2A 3TB5A 4FO8A 1YW7A 1R58A 2G6PA 4RZZA 3CTZA 3FMRA 5CE6A 1R5GA 2OAZA 2DFIA 2EVMA 4HXXA 3RORA 2GG3A 1C22A 2P99A 4IKTA 4PNCA 2Q96A 3FM3A 5CNXA 5E5BA 4A6WA 3L7GA 2OKNA 2Q8KA 2GG0A 2BWSA 1XGOA 4PV4A 3PKBA 4IF7A 2V3XA 4IECA 4RGZ1 2BWYA 4U69A 4ZWPA 5FCHA 3PKDA 3PKAA 1MATA 2GZ5A 4U6WA 5CDVA 1A16A 2V3YA 3IU7A 1CHMA 5JI6A 3IU9A 2BWTA 1WN1A 4IKUA 4A6VA 1XGMA 3PKCA 4QR8A 1R5HA 4IKRA 2GA2A 4OOKA 4U73A 2MATA 1W7VA 2EVOA 2Q95A 2GG8A 4S2RP 5FCFA 2BHDA 3S6BA 1W2MA 2GTXA 4FLLA 1WL6A 1C24A 1YVMA 2NQ7A 4FLKA 4ZWOA 1KP0A 5JHUA 2BHAA 2GU4A 2NQ6A 4FLIA 4IKSA 1C27A 1C23A 1WKMA 2GU5A 2BWXA 2B3HA 2Q93A 2BB7A 5CDLA 1WLRA 3TAVA 2ZSGA 4IDYA 1QXWA 4IPAA 3CB6A 3CB5A 1YW8A 4S00A 4U6ZA 1XGNA 2GGBA 4MATA 2HOWA 1WBQA 5CIKA 2Q94A 1YW9A 4FLJA 4ZWUA 4U71A 1YJ3A 2GU6A 4RZYA 3BIPA 3MATA 1M35A 5JFRA 4U75A 4EGEA 3RVAA 5CLSA 2EA2A 4KM3A 1C21A 1WL9A 2ADUA 5D6EA 4B28A 2B3KA 2BHBA 2GU7A 2BHCA 2BWVA 2BH3A 5CDEA 1XGSA 3IU8A 1BOAA 4Z7MA 3FMQA 4U6JA 2BWUA 2EA4A 4S01A 3IG4A 2BWWA 4FKCA 1QXZA 4U6EA 4U6CA 4U76A 1QXYA 2V6CA 2B3LA 2GG7A 1B6AA 3MR1A 4FUKA 2EVCA 3BIQA 2GG2A 1KQ9A 3PKEA 1BN5A 2BN7A 4U70A 5D6FA 3BITA 3D27A 2P98A 1JAWA 3Q6DA 4JUQA 2Q92A 2GGCA 2GG9A 4S2TP 4ZNGA 1PV9A 4FO7A 4R60A 4IU6A 2V3ZA 2IW2A 1Y1NA 1QZYA 3L24A 1N51A 1XNZA 3MX6A 1KQ0A 1O0XA 1B59A 2GG5A 2P9AA 4U1BA
chains in the Genus database with same CATH superfamily
1WY2A 3TB5A 4FO8A 1YW7A 1R58A 2G6PA 4RZZA 3CTZA 3FMRA 5CE6A 1R5GA 2OAZA 2DFIA 2EVMA 4HXXA 3RORA 2GG3A 1C22A 2P99A 4IKTA 4PNCA 2Q96A 3FM3A 5CNXA 5E5BA 4A6WA 3L7GA 2OKNA 2Q8KA 2GG0A 2BWSA 1XGOA 4PV4A 3PKBA 4IF7A 2V3XA 4IECA 4RGZ1 2BWYA 4U69A 4ZWPA 5FCHA 3PKDA 3PKAA 1MATA 2GZ5A 4U6WA 5CDVA 1A16A 2V3YA 3IU7A 1CHMA 5JI6A 3IU9A 2BWTA 1WN1A 4IKUA 4A6VA 1XGMA 3PKCA 4QR8A 1R5HA 4IKRA 2GA2A 4OOKA 4U73A 2MATA 1W7VA 2EVOA 2Q95A 2GG8A 4S2RP 5FCFA 2BHDA 3S6BA 1W2MA 2GTXA 4FLLA 1WL6A 1C24A 1YVMA 2NQ7A 4FLKA 4ZWOA 1KP0A 5JHUA 2BHAA 2GU4A 2NQ6A 4FLIA 4IKSA 1C27A 1C23A 1WKMA 2GU5A 2BWXA 2B3HA 2Q93A 2BB7A 5CDLA 1WLRA 3TAVA 2ZSGA 4IDYA 1QXWA 4IPAA 3CB6A 3CB5A 1YW8A 4S00A 4U6ZA 1XGNA 2GGBA 4MATA 2HOWA 1WBQA 5CIKA 2Q94A 1YW9A 4FLJA 4ZWUA 4U71A 1YJ3A 2GU6A 4RZYA 3BIPA 3MATA 1M35A 5JFRA 4U75A 4EGEA 3RVAA 5CLSA 2EA2A 4KM3A 1C21A 1WL9A 2ADUA 5D6EA 4B28A 2B3KA 2BHBA 2GU7A 2BHCA 2BWVA 2BH3A 5CDEA 1XGSA 3IU8A 1BOAA 4Z7MA 3FMQA 4U6JA 2BWUA 2EA4A 4S01A 3IG4A 2BWWA 4FKCA 1QXZA 4U6EA 4U6CA 4U76A 1QXYA 2V6CA 2B3LA 2GG7A 1B6AA 3MR1A 4FUKA 2EVCA 3BIQA 2GG2A 1KQ9A 3PKEA 1BN5A 2BN7A 4U70A 5D6FA 3BITA 3D27A 2P98A 1JAWA 3Q6DA 4JUQA 2Q92A 2GGCA 2GG9A 4S2TP 4ZNGA 1PV9A 4FO7A 4R60A 4IU6A 2V3ZA 2IW2A 1Y1NA 1QZYA 3L24A 1N51A 1XNZA 3MX6A 1KQ0A 1O0XA 1B59A 2GG5A 2P9AA 4U1BA
chains in the Genus database with same CATH topology
1WY2A 3TB5A 4FO8A 1YW7A 1R58A 2G6PA 4RZZA 3CTZA 3FMRA 5CE6A 1R5GA 2OAZA 2DFIA 2EVMA 4HXXA 3RORA 2GG3A 1C22A 2P99A 4IKTA 4PNCA 2Q96A 3FM3A 5CNXA 5E5BA 4A6WA 3L7GA 2OKNA 2Q8KA 2GG0A 2BWSA 1XGOA 4PV4A 3PKBA 4IF7A 2V3XA 4IECA 4RGZ1 2BWYA 4U69A 4ZWPA 5FCHA 3PKDA 3PKAA 1MATA 2GZ5A 4U6WA 5CDVA 1A16A 2V3YA 3IU7A 1CHMA 5JI6A 3IU9A 2BWTA 1WN1A 4IKUA 4A6VA 1XGMA 3PKCA 4QR8A 1R5HA 4IKRA 2GA2A 4OOKA 4U73A 2MATA 1W7VA 2EVOA 2Q95A 2GG8A 4S2RP 5FCFA 2BHDA 3S6BA 1W2MA 2GTXA 4FLLA 1WL6A 1C24A 1YVMA 2NQ7A 4FLKA 4ZWOA 1KP0A 5JHUA 2BHAA 2GU4A 2NQ6A 4FLIA 4IKSA 1C27A 1C23A 1WKMA 2GU5A 2BWXA 2B3HA 2Q93A 2BB7A 5CDLA 1WLRA 3TAVA 2ZSGA 4IDYA 1QXWA 4IPAA 3CB6A 3CB5A 1YW8A 4S00A 4U6ZA 1XGNA 2GGBA 4MATA 2HOWA 1WBQA 5CIKA 2Q94A 1YW9A 4FLJA 4ZWUA 4U71A 1YJ3A 2GU6A 4RZYA 3BIPA 3MATA 1M35A 5JFRA 4U75A 4EGEA 3RVAA 5CLSA 2EA2A 4KM3A 1C21A 1WL9A 2ADUA 5D6EA 4B28A 2B3KA 2BHBA 2GU7A 2BHCA 2BWVA 2BH3A 5CDEA 1XGSA 3IU8A 1BOAA 4Z7MA 3FMQA 4U6JA 2BWUA 2EA4A 4S01A 3IG4A 2BWWA 4FKCA 1QXZA 4U6EA 4U6CA 4U76A 1QXYA 2V6CA 2B3LA 2GG7A 1B6AA 3MR1A 4FUKA 2EVCA 3BIQA 2GG2A 1KQ9A 3PKEA 1BN5A 2BN7A 4U70A 5D6FA 3BITA 3D27A 2P98A 1JAWA 3Q6DA 4JUQA 2Q92A 2GGCA 2GG9A 4S2TP 4ZNGA 1PV9A 4FO7A 4R60A 4IU6A 2V3ZA 2IW2A 1Y1NA 1QZYA 3L24A 1N51A 1XNZA 3MX6A 1KQ0A 1O0XA 1B59A 2GG5A 2P9AA 4U1BA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1WY2 A;  3TB5 A;  4FO8 A;  1YW7 A;  1R58 A;  2G6P A;  4RZZ A;  3CTZ A;  3FMR A;  5CE6 A;  1R5G A;  2OAZ A;  2DFI A;  2EVM A;  4HXX A;  3ROR A;  2GG3 A;  1C22 A;  2P99 A;  4IKT A;  4PNC A;  2Q96 A;  3FM3 A;  5CNX A;  5E5B A;  4A6W A;  3L7G A;  2OKN A;  2Q8K A;  2GG0 A;  2BWS A;  1XGO A;  4PV4 A;  3PKB A;  4IF7 A;  2V3X A;  4IEC A;  4RGZ 1;  2BWY A;  4U69 A;  4ZWP A;  5FCH A;  3PKD A;  3PKA A;  1MAT A;  2GZ5 A;  4U6W A;  5CDV A;  1A16 A;  2V3Y A;  3IU7 A;  1CHM A;  5JI6 A;  3IU9 A;  2BWT A;  1WN1 A;  4IKU A;  4A6V A;  1XGM A;  3PKC A;  4QR8 A;  1R5H A;  4IKR A;  2GA2 A;  4OOK A;  4U73 A;  2MAT A;  1W7V A;  2EVO A;  2Q95 A;  2GG8 A;  4S2R P;  5FCF A;  2BHD A;  3S6B A;  1W2M A;  2GTX A;  4FLL A;  1WL6 A;  1C24 A;  1YVM A;  2NQ7 A;  4FLK A;  4ZWO A;  1KP0 A;  5JHU A;  2BHA A;  2GU4 A;  2NQ6 A;  4FLI A;  4IKS A;  1C27 A;  1C23 A;  1WKM A;  2GU5 A;  2BWX A;  2B3H A;  2Q93 A;  2BB7 A;  5CDL A;  1WLR A;  3TAV A;  2ZSG A;  4IDY A;  1QXW A;  4IPA A;  3CB6 A;  3CB5 A;  1YW8 A;  4S00 A;  4U6Z A;  1XGN A;  2GGB A;  4MAT A;  2HOW A;  1WBQ A;  5CIK A;  2Q94 A;  1YW9 A;  4FLJ A;  4ZWU A;  4U71 A;  1YJ3 A;  2GU6 A;  4RZY A;  3BIP A;  3MAT A;  1M35 A;  5JFR A;  4U75 A;  4EGE A;  3RVA A;  5CLS A;  2EA2 A;  4KM3 A;  1C21 A;  1WL9 A;  2ADU A;  5D6E A;  4B28 A;  2B3K A;  2BHB A;  2GU7 A;  2BHC A;  2BWV A;  2BH3 A;  5CDE A;  1XGS A;  3IU8 A;  1BOA A;  4Z7M A;  3FMQ A;  4U6J A;  2BWU A;  2EA4 A;  4S01 A;  3IG4 A;  2BWW A;  4FKC A;  1QXZ A;  4U6E A;  4U6C A;  4U76 A;  1QXY A;  2V6C A;  2B3L A;  2GG7 A;  1B6A A;  3MR1 A;  4FUK A;  2EVC A;  3BIQ A;  2GG2 A;  1KQ9 A;  3PKE A;  1BN5 A;  2BN7 A;  4U70 A;  5D6F A;  3BIT A;  3D27 A;  2P98 A;  1JAW A;  3Q6D A;  4JUQ A;  2Q92 A;  2GGC A;  2GG9 A;  4S2T P;  4ZNG A;  1PV9 A;  4FO7 A;  4R60 A;  4IU6 A;  2V3Z A;  2IW2 A;  1Y1N A;  1QZY A;  3L24 A;  1N51 A;  1XNZ A;  3MX6 A;  1KQ0 A;  1O0X A;  1B59 A;  2GG5 A;  2P9A A;  4U1B A; 
#chains in the Genus database with same CATH topology
 1WY2 A;  3TB5 A;  4FO8 A;  1YW7 A;  1R58 A;  2G6P A;  4RZZ A;  3CTZ A;  3FMR A;  5CE6 A;  1R5G A;  2OAZ A;  2DFI A;  2EVM A;  4HXX A;  3ROR A;  2GG3 A;  1C22 A;  2P99 A;  4IKT A;  4PNC A;  2Q96 A;  3FM3 A;  5CNX A;  5E5B A;  4A6W A;  3L7G A;  2OKN A;  2Q8K A;  2GG0 A;  2BWS A;  1XGO A;  4PV4 A;  3PKB A;  4IF7 A;  2V3X A;  4IEC A;  4RGZ 1;  2BWY A;  4U69 A;  4ZWP A;  5FCH A;  3PKD A;  3PKA A;  1MAT A;  2GZ5 A;  4U6W A;  5CDV A;  1A16 A;  2V3Y A;  3IU7 A;  1CHM A;  5JI6 A;  3IU9 A;  2BWT A;  1WN1 A;  4IKU A;  4A6V A;  1XGM A;  3PKC A;  4QR8 A;  1R5H A;  4IKR A;  2GA2 A;  4OOK A;  4U73 A;  2MAT A;  1W7V A;  2EVO A;  2Q95 A;  2GG8 A;  4S2R P;  5FCF A;  2BHD A;  3S6B A;  1W2M A;  2GTX A;  4FLL A;  1WL6 A;  1C24 A;  1YVM A;  2NQ7 A;  4FLK A;  4ZWO A;  1KP0 A;  5JHU A;  2BHA A;  2GU4 A;  2NQ6 A;  4FLI A;  4IKS A;  1C27 A;  1C23 A;  1WKM A;  2GU5 A;  2BWX A;  2B3H A;  2Q93 A;  2BB7 A;  5CDL A;  1WLR A;  3TAV A;  2ZSG A;  4IDY A;  1QXW A;  4IPA A;  3CB6 A;  3CB5 A;  1YW8 A;  4S00 A;  4U6Z A;  1XGN A;  2GGB A;  4MAT A;  2HOW A;  1WBQ A;  5CIK A;  2Q94 A;  1YW9 A;  4FLJ A;  4ZWU A;  4U71 A;  1YJ3 A;  2GU6 A;  4RZY A;  3BIP A;  3MAT A;  1M35 A;  5JFR A;  4U75 A;  4EGE A;  3RVA A;  5CLS A;  2EA2 A;  4KM3 A;  1C21 A;  1WL9 A;  2ADU A;  5D6E A;  4B28 A;  2B3K A;  2BHB A;  2GU7 A;  2BHC A;  2BWV A;  2BH3 A;  5CDE A;  1XGS A;  3IU8 A;  1BOA A;  4Z7M A;  3FMQ A;  4U6J A;  2BWU A;  2EA4 A;  4S01 A;  3IG4 A;  2BWW A;  4FKC A;  1QXZ A;  4U6E A;  4U6C A;  4U76 A;  1QXY A;  2V6C A;  2B3L A;  2GG7 A;  1B6A A;  3MR1 A;  4FUK A;  2EVC A;  3BIQ A;  2GG2 A;  1KQ9 A;  3PKE A;  1BN5 A;  2BN7 A;  4U70 A;  5D6F A;  3BIT A;  3D27 A;  2P98 A;  1JAW A;  3Q6D A;  4JUQ A;  2Q92 A;  2GGC A;  2GG9 A;  4S2T P;  4ZNG A;  1PV9 A;  4FO7 A;  4R60 A;  4IU6 A;  2V3Z A;  2IW2 A;  1Y1N A;  1QZY A;  3L24 A;  1N51 A;  1XNZ A;  3MX6 A;  1KQ0 A;  1O0X A;  1B59 A;  2GG5 A;  2P9A A;  4U1B A; 
#chains in the Genus database with same CATH homology
 1WY2 A;  3TB5 A;  4FO8 A;  1YW7 A;  1R58 A;  2G6P A;  4RZZ A;  3CTZ A;  3FMR A;  5CE6 A;  1R5G A;  2OAZ A;  2DFI A;  2EVM A;  4HXX A;  3ROR A;  2GG3 A;  1C22 A;  2P99 A;  4IKT A;  4PNC A;  2Q96 A;  3FM3 A;  5CNX A;  5E5B A;  4A6W A;  3L7G A;  2OKN A;  2Q8K A;  2GG0 A;  2BWS A;  1XGO A;  4PV4 A;  3PKB A;  4IF7 A;  2V3X A;  4IEC A;  4RGZ 1;  2BWY A;  4U69 A;  4ZWP A;  5FCH A;  3PKD A;  3PKA A;  1MAT A;  2GZ5 A;  4U6W A;  5CDV A;  1A16 A;  2V3Y A;  3IU7 A;  1CHM A;  5JI6 A;  3IU9 A;  2BWT A;  1WN1 A;  4IKU A;  4A6V A;  1XGM A;  3PKC A;  4QR8 A;  1R5H A;  4IKR A;  2GA2 A;  4OOK A;  4U73 A;  2MAT A;  1W7V A;  2EVO A;  2Q95 A;  2GG8 A;  4S2R P;  5FCF A;  2BHD A;  3S6B A;  1W2M A;  2GTX A;  4FLL A;  1WL6 A;  1C24 A;  1YVM A;  2NQ7 A;  4FLK A;  4ZWO A;  1KP0 A;  5JHU A;  2BHA A;  2GU4 A;  2NQ6 A;  4FLI A;  4IKS A;  1C27 A;  1C23 A;  1WKM A;  2GU5 A;  2BWX A;  2B3H A;  2Q93 A;  2BB7 A;  5CDL A;  1WLR A;  3TAV A;  2ZSG A;  4IDY A;  1QXW A;  4IPA A;  3CB6 A;  3CB5 A;  1YW8 A;  4S00 A;  4U6Z A;  1XGN A;  2GGB A;  4MAT A;  2HOW A;  1WBQ A;  5CIK A;  2Q94 A;  1YW9 A;  4FLJ A;  4ZWU A;  4U71 A;  1YJ3 A;  2GU6 A;  4RZY A;  3BIP A;  3MAT A;  1M35 A;  5JFR A;  4U75 A;  4EGE A;  3RVA A;  5CLS A;  2EA2 A;  4KM3 A;  1C21 A;  1WL9 A;  2ADU A;  5D6E A;  4B28 A;  2B3K A;  2BHB A;  2GU7 A;  2BHC A;  2BWV A;  2BH3 A;  5CDE A;  1XGS A;  3IU8 A;  1BOA A;  4Z7M A;  3FMQ A;  4U6J A;  2BWU A;  2EA4 A;  4S01 A;  3IG4 A;  2BWW A;  4FKC A;  1QXZ A;  4U6E A;  4U6C A;  4U76 A;  1QXY A;  2V6C A;  2B3L A;  2GG7 A;  1B6A A;  3MR1 A;  4FUK A;  2EVC A;  3BIQ A;  2GG2 A;  1KQ9 A;  3PKE A;  1BN5 A;  2BN7 A;  4U70 A;  5D6F A;  3BIT A;  3D27 A;  2P98 A;  1JAW A;  3Q6D A;  4JUQ A;  2Q92 A;  2GGC A;  2GG9 A;  4S2T P;  4ZNG A;  1PV9 A;  4FO7 A;  4R60 A;  4IU6 A;  2V3Z A;  2IW2 A;  1Y1N A;  1QZY A;  3L24 A;  1N51 A;  1XNZ A;  3MX6 A;  1KQ0 A;  1O0X A;  1B59 A;  2GG5 A;  2P9A A;  4U1B A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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