4U71A

Hsmetap(f309m) in complex with 1- amino(cyclohexyl)methy)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u71A00
5JI6A 1WY2A 1M35A 2BWYA 1C27A 2P99A 2Q95A 3FMRA 2ADUA 3Q6DA 3IU9A 4QR8A 5CDLA 1KQ0A 2Q96A 2Q92A 1YJ3A 4RGZ1 2BHCA 2G6PA 2IW2A 2BWXA 1QXYA 4FO8A 1R58A 4IECA 4A6VA 1R5GA 2HOWA 2EA2A 2BWVA 1CHMA 2GG9A 1QXWA 2GU6A 3RVAA 2GG5A 1N51A 3PKDA 2BHBA 3IU7A 1C21A 3BITA 4U76A 4U1BA 2BHAA 4FLJA 4IKRA 5D6EA 4U6ZA 4S2TP 3MX6A 5D6FA 1C23A 5E5BA 4B28A 1XGMA 4S2RP 1KP0A 1QZYA 3PKBA 1R5HA 3FMQA 1PV9A 3FM3A 2NQ6A 3CB5A 3IU8A 4U75A 1C22A 2Q94A 1BN5A 1C24A 1WKMA 5CLSA 4Z7MA 2DFIA 3RORA 1WLRA 4U6WA 4U69A 1YW9A 4ZWUA 3TB5A 3MR1A 2P9AA 3BIPA 4IKSA 3PKAA 2EVMA 2GU4A 1YW8A 4PNCA 4U70A 2GG2A 2OKNA 4U6JA 4R60A 1YVMA 1QXZA 4IF7A 4ZWPA 2B3KA 4PV4A 2GG8A 3CTZA 2MATA 2GU7A 4HXXA 2V3YA 3PKEA 2BWTA 3L24A 2GU5A 2GG0A 2GA2A 2V3XA 3CB6A 1O0XA 2GG7A 3PKCA 3BIQA 4JUQA 3MATA 2BN7A 2GTXA 2NQ7A 5JFRA 1B59A 3D27A 3L7GA 1XGSA 1Y1NA 2BB7A 2GGCA 4EGEA 2V3ZA 5CIKA 1XGNA 5CNXA 4FUKA 4A6WA 4S01A 4U73A 5CE6A 1JAWA 1XNZA 2Q93A 4IKTA 4U6CA 4FLLA 1XGOA 1KQ9A 4IDYA 2EVCA 2P98A 4KM3A 1BOAA 5FCFA 1W2MA 5CDEA 5JHUA 2BH3A 4IPAA 1B6AA 1WBQA 4RZYA 5CDVA 4IKUA 4FLIA 1WN1A 2BWWA 4FLKA 4RZZA 2B3LA 4U6EA 2EA4A 2BWUA 4FO7A 2GG3A 4ZWOA 4MATA 3S6BA 4ZNGA 4S00A 4FKCA 2Q8KA 2B3HA 4U71A 2BWSA 1MATA 2ZSGA 3TAVA 5FCHA 1A16A 4OOKA 2V6CA 2EVOA 4IU6A 2GZ5A 3IG4A 1YW7A 2GGBA 1W7VA 1WL9A 2OAZA 1WL6A 2BHDA
chains in the Genus database with same CATH superfamily
5JI6A 1WY2A 1M35A 2BWYA 1C27A 2P99A 2Q95A 3FMRA 2ADUA 3Q6DA 3IU9A 4QR8A 5CDLA 1KQ0A 2Q96A 2Q92A 1YJ3A 4RGZ1 2BHCA 2G6PA 2IW2A 2BWXA 1QXYA 4FO8A 1R58A 4IECA 4A6VA 1R5GA 2HOWA 2EA2A 2BWVA 1CHMA 2GG9A 1QXWA 2GU6A 3RVAA 2GG5A 1N51A 3PKDA 2BHBA 3IU7A 1C21A 3BITA 4U76A 4U1BA 2BHAA 4FLJA 4IKRA 5D6EA 4U6ZA 4S2TP 3MX6A 5D6FA 1C23A 5E5BA 4B28A 1XGMA 4S2RP 1KP0A 1QZYA 3PKBA 1R5HA 3FMQA 1PV9A 3FM3A 2NQ6A 3CB5A 3IU8A 4U75A 1C22A 2Q94A 1BN5A 1C24A 1WKMA 5CLSA 4Z7MA 2DFIA 3RORA 1WLRA 4U6WA 4U69A 1YW9A 4ZWUA 3TB5A 3MR1A 2P9AA 3BIPA 4IKSA 3PKAA 2EVMA 2GU4A 1YW8A 4PNCA 4U70A 2GG2A 2OKNA 4U6JA 4R60A 1YVMA 1QXZA 4IF7A 4ZWPA 2B3KA 4PV4A 2GG8A 3CTZA 2MATA 2GU7A 4HXXA 2V3YA 3PKEA 2BWTA 3L24A 2GU5A 2GG0A 2GA2A 2V3XA 3CB6A 1O0XA 2GG7A 3PKCA 3BIQA 4JUQA 3MATA 2BN7A 2GTXA 2NQ7A 5JFRA 1B59A 3D27A 3L7GA 1XGSA 1Y1NA 2BB7A 2GGCA 4EGEA 2V3ZA 5CIKA 1XGNA 5CNXA 4FUKA 4A6WA 4S01A 4U73A 5CE6A 1JAWA 1XNZA 2Q93A 4IKTA 4U6CA 4FLLA 1XGOA 1KQ9A 4IDYA 2EVCA 2P98A 4KM3A 1BOAA 5FCFA 1W2MA 5CDEA 5JHUA 2BH3A 4IPAA 1B6AA 1WBQA 4RZYA 5CDVA 4IKUA 4FLIA 1WN1A 2BWWA 4FLKA 4RZZA 2B3LA 4U6EA 2EA4A 2BWUA 4FO7A 2GG3A 4ZWOA 4MATA 3S6BA 4ZNGA 4S00A 4FKCA 2Q8KA 2B3HA 4U71A 2BWSA 1MATA 2ZSGA 3TAVA 5FCHA 1A16A 4OOKA 2V6CA 2EVOA 4IU6A 2GZ5A 3IG4A 1YW7A 2GGBA 1W7VA 1WL9A 2OAZA 1WL6A 2BHDA
chains in the Genus database with same CATH topology
5JI6A 1WY2A 1M35A 2BWYA 1C27A 2P99A 2Q95A 3FMRA 2ADUA 3Q6DA 3IU9A 4QR8A 5CDLA 1KQ0A 2Q96A 2Q92A 1YJ3A 4RGZ1 2BHCA 2G6PA 2IW2A 2BWXA 1QXYA 4FO8A 1R58A 4IECA 4A6VA 1R5GA 2HOWA 2EA2A 2BWVA 1CHMA 2GG9A 1QXWA 2GU6A 3RVAA 2GG5A 1N51A 3PKDA 2BHBA 3IU7A 1C21A 3BITA 4U76A 4U1BA 2BHAA 4FLJA 4IKRA 5D6EA 4U6ZA 4S2TP 3MX6A 5D6FA 1C23A 5E5BA 4B28A 1XGMA 4S2RP 1KP0A 1QZYA 3PKBA 1R5HA 3FMQA 1PV9A 3FM3A 2NQ6A 3CB5A 3IU8A 4U75A 1C22A 2Q94A 1BN5A 1C24A 1WKMA 5CLSA 4Z7MA 2DFIA 3RORA 1WLRA 4U6WA 4U69A 1YW9A 4ZWUA 3TB5A 3MR1A 2P9AA 3BIPA 4IKSA 3PKAA 2EVMA 2GU4A 1YW8A 4PNCA 4U70A 2GG2A 2OKNA 4U6JA 4R60A 1YVMA 1QXZA 4IF7A 4ZWPA 2B3KA 4PV4A 2GG8A 3CTZA 2MATA 2GU7A 4HXXA 2V3YA 3PKEA 2BWTA 3L24A 2GU5A 2GG0A 2GA2A 2V3XA 3CB6A 1O0XA 2GG7A 3PKCA 3BIQA 4JUQA 3MATA 2BN7A 2GTXA 2NQ7A 5JFRA 1B59A 3D27A 3L7GA 1XGSA 1Y1NA 2BB7A 2GGCA 4EGEA 2V3ZA 5CIKA 1XGNA 5CNXA 4FUKA 4A6WA 4S01A 4U73A 5CE6A 1JAWA 1XNZA 2Q93A 4IKTA 4U6CA 4FLLA 1XGOA 1KQ9A 4IDYA 2EVCA 2P98A 4KM3A 1BOAA 5FCFA 1W2MA 5CDEA 5JHUA 2BH3A 4IPAA 1B6AA 1WBQA 4RZYA 5CDVA 4IKUA 4FLIA 1WN1A 2BWWA 4FLKA 4RZZA 2B3LA 4U6EA 2EA4A 2BWUA 4FO7A 2GG3A 4ZWOA 4MATA 3S6BA 4ZNGA 4S00A 4FKCA 2Q8KA 2B3HA 4U71A 2BWSA 1MATA 2ZSGA 3TAVA 5FCHA 1A16A 4OOKA 2V6CA 2EVOA 4IU6A 2GZ5A 3IG4A 1YW7A 2GGBA 1W7VA 1WL9A 2OAZA 1WL6A 2BHDA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 5JI6 A;  1WY2 A;  1M35 A;  2BWY A;  1C27 A;  2P99 A;  2Q95 A;  3FMR A;  2ADU A;  3Q6D A;  3IU9 A;  4QR8 A;  5CDL A;  1KQ0 A;  2Q96 A;  2Q92 A;  1YJ3 A;  4RGZ 1;  2BHC A;  2G6P A;  2IW2 A;  2BWX A;  1QXY A;  4FO8 A;  1R58 A;  4IEC A;  4A6V A;  1R5G A;  2HOW A;  2EA2 A;  2BWV A;  1CHM A;  2GG9 A;  1QXW A;  2GU6 A;  3RVA A;  2GG5 A;  1N51 A;  3PKD A;  2BHB A;  3IU7 A;  1C21 A;  3BIT A;  4U76 A;  4U1B A;  2BHA A;  4FLJ A;  4IKR A;  5D6E A;  4U6Z A;  4S2T P;  3MX6 A;  5D6F A;  1C23 A;  5E5B A;  4B28 A;  1XGM A;  4S2R P;  1KP0 A;  1QZY A;  3PKB A;  1R5H A;  3FMQ A;  1PV9 A;  3FM3 A;  2NQ6 A;  3CB5 A;  3IU8 A;  4U75 A;  1C22 A;  2Q94 A;  1BN5 A;  1C24 A;  1WKM A;  5CLS A;  4Z7M A;  2DFI A;  3ROR A;  1WLR A;  4U6W A;  4U69 A;  1YW9 A;  4ZWU A;  3TB5 A;  3MR1 A;  2P9A A;  3BIP A;  4IKS A;  3PKA A;  2EVM A;  2GU4 A;  1YW8 A;  4PNC A;  4U70 A;  2GG2 A;  2OKN A;  4U6J A;  4R60 A;  1YVM A;  1QXZ A;  4IF7 A;  4ZWP A;  2B3K A;  4PV4 A;  2GG8 A;  3CTZ A;  2MAT A;  2GU7 A;  4HXX A;  2V3Y A;  3PKE A;  2BWT A;  3L24 A;  2GU5 A;  2GG0 A;  2GA2 A;  2V3X A;  3CB6 A;  1O0X A;  2GG7 A;  3PKC A;  3BIQ A;  4JUQ A;  3MAT A;  2BN7 A;  2GTX A;  2NQ7 A;  5JFR A;  1B59 A;  3D27 A;  3L7G A;  1XGS A;  1Y1N A;  2BB7 A;  2GGC A;  4EGE A;  2V3Z A;  5CIK A;  1XGN A;  5CNX A;  4FUK A;  4A6W A;  4S01 A;  4U73 A;  5CE6 A;  1JAW A;  1XNZ A;  2Q93 A;  4IKT A;  4U6C A;  4FLL A;  1XGO A;  1KQ9 A;  4IDY A;  2EVC A;  2P98 A;  4KM3 A;  1BOA A;  5FCF A;  1W2M A;  5CDE A;  5JHU A;  2BH3 A;  4IPA A;  1B6A A;  1WBQ A;  4RZY A;  5CDV A;  4IKU A;  4FLI A;  1WN1 A;  2BWW A;  4FLK A;  4RZZ A;  2B3L A;  4U6E A;  2EA4 A;  2BWU A;  4FO7 A;  2GG3 A;  4ZWO A;  4MAT A;  3S6B A;  4ZNG A;  4S00 A;  4FKC A;  2Q8K A;  2B3H A;  4U71 A;  2BWS A;  1MAT A;  2ZSG A;  3TAV A;  5FCH A;  1A16 A;  4OOK A;  2V6C A;  2EVO A;  4IU6 A;  2GZ5 A;  3IG4 A;  1YW7 A;  2GGB A;  1W7V A;  1WL9 A;  2OAZ A;  1WL6 A;  2BHD A; 
#chains in the Genus database with same CATH topology
 5JI6 A;  1WY2 A;  1M35 A;  2BWY A;  1C27 A;  2P99 A;  2Q95 A;  3FMR A;  2ADU A;  3Q6D A;  3IU9 A;  4QR8 A;  5CDL A;  1KQ0 A;  2Q96 A;  2Q92 A;  1YJ3 A;  4RGZ 1;  2BHC A;  2G6P A;  2IW2 A;  2BWX A;  1QXY A;  4FO8 A;  1R58 A;  4IEC A;  4A6V A;  1R5G A;  2HOW A;  2EA2 A;  2BWV A;  1CHM A;  2GG9 A;  1QXW A;  2GU6 A;  3RVA A;  2GG5 A;  1N51 A;  3PKD A;  2BHB A;  3IU7 A;  1C21 A;  3BIT A;  4U76 A;  4U1B A;  2BHA A;  4FLJ A;  4IKR A;  5D6E A;  4U6Z A;  4S2T P;  3MX6 A;  5D6F A;  1C23 A;  5E5B A;  4B28 A;  1XGM A;  4S2R P;  1KP0 A;  1QZY A;  3PKB A;  1R5H A;  3FMQ A;  1PV9 A;  3FM3 A;  2NQ6 A;  3CB5 A;  3IU8 A;  4U75 A;  1C22 A;  2Q94 A;  1BN5 A;  1C24 A;  1WKM A;  5CLS A;  4Z7M A;  2DFI A;  3ROR A;  1WLR A;  4U6W A;  4U69 A;  1YW9 A;  4ZWU A;  3TB5 A;  3MR1 A;  2P9A A;  3BIP A;  4IKS A;  3PKA A;  2EVM A;  2GU4 A;  1YW8 A;  4PNC A;  4U70 A;  2GG2 A;  2OKN A;  4U6J A;  4R60 A;  1YVM A;  1QXZ A;  4IF7 A;  4ZWP A;  2B3K A;  4PV4 A;  2GG8 A;  3CTZ A;  2MAT A;  2GU7 A;  4HXX A;  2V3Y A;  3PKE A;  2BWT A;  3L24 A;  2GU5 A;  2GG0 A;  2GA2 A;  2V3X A;  3CB6 A;  1O0X A;  2GG7 A;  3PKC A;  3BIQ A;  4JUQ A;  3MAT A;  2BN7 A;  2GTX A;  2NQ7 A;  5JFR A;  1B59 A;  3D27 A;  3L7G A;  1XGS A;  1Y1N A;  2BB7 A;  2GGC A;  4EGE A;  2V3Z A;  5CIK A;  1XGN A;  5CNX A;  4FUK A;  4A6W A;  4S01 A;  4U73 A;  5CE6 A;  1JAW A;  1XNZ A;  2Q93 A;  4IKT A;  4U6C A;  4FLL A;  1XGO A;  1KQ9 A;  4IDY A;  2EVC A;  2P98 A;  4KM3 A;  1BOA A;  5FCF A;  1W2M A;  5CDE A;  5JHU A;  2BH3 A;  4IPA A;  1B6A A;  1WBQ A;  4RZY A;  5CDV A;  4IKU A;  4FLI A;  1WN1 A;  2BWW A;  4FLK A;  4RZZ A;  2B3L A;  4U6E A;  2EA4 A;  2BWU A;  4FO7 A;  2GG3 A;  4ZWO A;  4MAT A;  3S6B A;  4ZNG A;  4S00 A;  4FKC A;  2Q8K A;  2B3H A;  4U71 A;  2BWS A;  1MAT A;  2ZSG A;  3TAV A;  5FCH A;  1A16 A;  4OOK A;  2V6C A;  2EVO A;  4IU6 A;  2GZ5 A;  3IG4 A;  1YW7 A;  2GGB A;  1W7V A;  1WL9 A;  2OAZ A;  1WL6 A;  2BHD A; 
#chains in the Genus database with same CATH homology
 5JI6 A;  1WY2 A;  1M35 A;  2BWY A;  1C27 A;  2P99 A;  2Q95 A;  3FMR A;  2ADU A;  3Q6D A;  3IU9 A;  4QR8 A;  5CDL A;  1KQ0 A;  2Q96 A;  2Q92 A;  1YJ3 A;  4RGZ 1;  2BHC A;  2G6P A;  2IW2 A;  2BWX A;  1QXY A;  4FO8 A;  1R58 A;  4IEC A;  4A6V A;  1R5G A;  2HOW A;  2EA2 A;  2BWV A;  1CHM A;  2GG9 A;  1QXW A;  2GU6 A;  3RVA A;  2GG5 A;  1N51 A;  3PKD A;  2BHB A;  3IU7 A;  1C21 A;  3BIT A;  4U76 A;  4U1B A;  2BHA A;  4FLJ A;  4IKR A;  5D6E A;  4U6Z A;  4S2T P;  3MX6 A;  5D6F A;  1C23 A;  5E5B A;  4B28 A;  1XGM A;  4S2R P;  1KP0 A;  1QZY A;  3PKB A;  1R5H A;  3FMQ A;  1PV9 A;  3FM3 A;  2NQ6 A;  3CB5 A;  3IU8 A;  4U75 A;  1C22 A;  2Q94 A;  1BN5 A;  1C24 A;  1WKM A;  5CLS A;  4Z7M A;  2DFI A;  3ROR A;  1WLR A;  4U6W A;  4U69 A;  1YW9 A;  4ZWU A;  3TB5 A;  3MR1 A;  2P9A A;  3BIP A;  4IKS A;  3PKA A;  2EVM A;  2GU4 A;  1YW8 A;  4PNC A;  4U70 A;  2GG2 A;  2OKN A;  4U6J A;  4R60 A;  1YVM A;  1QXZ A;  4IF7 A;  4ZWP A;  2B3K A;  4PV4 A;  2GG8 A;  3CTZ A;  2MAT A;  2GU7 A;  4HXX A;  2V3Y A;  3PKE A;  2BWT A;  3L24 A;  2GU5 A;  2GG0 A;  2GA2 A;  2V3X A;  3CB6 A;  1O0X A;  2GG7 A;  3PKC A;  3BIQ A;  4JUQ A;  3MAT A;  2BN7 A;  2GTX A;  2NQ7 A;  5JFR A;  1B59 A;  3D27 A;  3L7G A;  1XGS A;  1Y1N A;  2BB7 A;  2GGC A;  4EGE A;  2V3Z A;  5CIK A;  1XGN A;  5CNX A;  4FUK A;  4A6W A;  4S01 A;  4U73 A;  5CE6 A;  1JAW A;  1XNZ A;  2Q93 A;  4IKT A;  4U6C A;  4FLL A;  1XGO A;  1KQ9 A;  4IDY A;  2EVC A;  2P98 A;  4KM3 A;  1BOA A;  5FCF A;  1W2M A;  5CDE A;  5JHU A;  2BH3 A;  4IPA A;  1B6A A;  1WBQ A;  4RZY A;  5CDV A;  4IKU A;  4FLI A;  1WN1 A;  2BWW A;  4FLK A;  4RZZ A;  2B3L A;  4U6E A;  2EA4 A;  2BWU A;  4FO7 A;  2GG3 A;  4ZWO A;  4MAT A;  3S6B A;  4ZNG A;  4S00 A;  4FKC A;  2Q8K A;  2B3H A;  4U71 A;  2BWS A;  1MAT A;  2ZSG A;  3TAV A;  5FCH A;  1A16 A;  4OOK A;  2V6C A;  2EVO A;  4IU6 A;  2GZ5 A;  3IG4 A;  1YW7 A;  2GGB A;  1W7V A;  1WL9 A;  2OAZ A;  1WL6 A;  2BHD A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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