4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule tags Hydrolase
source organism Homo sapiens
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
3CB6A 1C27A 4IECA 4FO8A 4QR8A 5FCFA 5CIKA 1BOAA 3CTZA 2EVCA 3MATA 2GG0A 4FLLA 2BHDA 1C21A 4B28A 4IKSA 4U69A 1PV9A 2P99A 1A16A 1MATA 1C22A 2ZSGA 2B3KA 2Q92A 5JFRA 3BITA 4EGEA 3L24A 4OOKA 2GGBA 5E5BA 2IW2A 2DFIA 2ADUA 2Q94A 1KQ0A 2G6PA 2BWWA 3BIQA 3PKAA 2HOWA 2BHCA 4ZNGA 1CHMA 4S01A 5D6FA 1WY2A 1QXYA 5JI6A 5CDLA 1YW8A 2P98A 1Y1NA 2GG5A 1XGOA 1B59A 3MR1A 4A6VA 2BN7A 1WKMA 3PKEA 5JHUA 1WLRA 3IU7A 4U76A 4IPAA 2NQ7A 3PKBA 4FKCA 4U73A 2EVMA 4IKUA 4U6JA 2OKNA 4FLKA 2GU4A 4IKRA 1R58A 1XNZA 3PKDA 4FLJA 1YW9A 4FLIA 2Q93A 4S2TP 1M35A 2BH3A 3TB5A 1N51A 2BHBA 2BWUA 1C24A 2GG3A 2GG8A 3RVAA 4ZWPA 1R5HA 3IU9A 2BWVA 4HXXA 2GU6A 3BIPA 1YVMA 4IKTA 1KP0A 2EVOA 3D27A 4KM3A 1XGNA 4JUQA 3S6BA 4U6EA 2GA2A 1WL6A 4U6ZA 5D6EA 5CNXA 4U6CA 2MATA 1C23A 2Q8KA 2B3LA 2GTXA 3Q6DA 1BN5A 1O0XA 2V3YA 4IF7A 5FCHA 1YW7A 4RGZ1 2EA2A 2GZ5A 1XGSA 4U1BA 4R60A 4U71A 5CDEA 3IG4A 4RZYA 4ZWUA 1QXZA 3FMRA 4PV4A 4FUKA 4MATA 1W2MA 1WN1A 2GU7A 4RZZA 4S2RP 3TAVA 2B3HA 2GGCA 2V3ZA 1R5GA 4FO7A 4S00A 2NQ6A 4IU6A 2P9AA 3FMQA 4Z7MA 1WBQA 2GG2A 2GG9A 1XGMA 2BWYA 3L7GA 5CLSA 2EA4A 2GG7A 2OAZA 4U75A 2Q95A 2BWXA 1KQ9A 2BB7A 4PNCA 1QZYA 1QXWA 1WL9A 4U6WA 4ZWOA 1B6AA 3FM3A 2BWSA 2V6CA 2BHAA 1W7VA 3CB5A 4A6WA 3IU8A 3RORA 3PKCA 5CDVA 2GU5A 4U70A 2Q96A 2V3XA 1JAWA 4IDYA 5CE6A 2BWTA 1YJ3A 3MX6A
chains in the Genus database with same CATH superfamily
3CB6A 1C27A 4IECA 4FO8A 4QR8A 5FCFA 5CIKA 1BOAA 3CTZA 2EVCA 3MATA 2GG0A 4FLLA 2BHDA 1C21A 4B28A 4IKSA 4U69A 1PV9A 2P99A 1A16A 1MATA 1C22A 2ZSGA 2B3KA 2Q92A 5JFRA 3BITA 4EGEA 3L24A 4OOKA 2GGBA 5E5BA 2IW2A 2DFIA 2ADUA 2Q94A 1KQ0A 2G6PA 2BWWA 3BIQA 3PKAA 2HOWA 2BHCA 4ZNGA 1CHMA 4S01A 5D6FA 1WY2A 1QXYA 5JI6A 5CDLA 1YW8A 2P98A 1Y1NA 2GG5A 1XGOA 1B59A 3MR1A 4A6VA 2BN7A 1WKMA 3PKEA 5JHUA 1WLRA 3IU7A 4U76A 4IPAA 2NQ7A 3PKBA 4FKCA 4U73A 2EVMA 4IKUA 4U6JA 2OKNA 4FLKA 2GU4A 4IKRA 1R58A 1XNZA 3PKDA 4FLJA 1YW9A 4FLIA 2Q93A 4S2TP 1M35A 2BH3A 3TB5A 1N51A 2BHBA 2BWUA 1C24A 2GG3A 2GG8A 3RVAA 4ZWPA 1R5HA 3IU9A 2BWVA 4HXXA 2GU6A 3BIPA 1YVMA 4IKTA 1KP0A 2EVOA 3D27A 4KM3A 1XGNA 4JUQA 3S6BA 4U6EA 2GA2A 1WL6A 4U6ZA 5D6EA 5CNXA 4U6CA 2MATA 1C23A 2Q8KA 2B3LA 2GTXA 3Q6DA 1BN5A 1O0XA 2V3YA 4IF7A 5FCHA 1YW7A 4RGZ1 2EA2A 2GZ5A 1XGSA 4U1BA 4R60A 4U71A 5CDEA 3IG4A 4RZYA 4ZWUA 1QXZA 3FMRA 4PV4A 4FUKA 4MATA 1W2MA 1WN1A 2GU7A 4RZZA 4S2RP 3TAVA 2B3HA 2GGCA 2V3ZA 1R5GA 4FO7A 4S00A 2NQ6A 4IU6A 2P9AA 3FMQA 4Z7MA 1WBQA 2GG2A 2GG9A 1XGMA 2BWYA 3L7GA 5CLSA 2EA4A 2GG7A 2OAZA 4U75A 2Q95A 2BWXA 1KQ9A 2BB7A 4PNCA 1QZYA 1QXWA 1WL9A 4U6WA 4ZWOA 1B6AA 3FM3A 2BWSA 2V6CA 2BHAA 1W7VA 3CB5A 4A6WA 3IU8A 3RORA 3PKCA 5CDVA 2GU5A 4U70A 2Q96A 2V3XA 1JAWA 4IDYA 5CE6A 2BWTA 1YJ3A 3MX6A
chains in the Genus database with same CATH topology
3CB6A 1C27A 4IECA 4FO8A 4QR8A 5FCFA 5CIKA 1BOAA 3CTZA 2EVCA 3MATA 2GG0A 4FLLA 2BHDA 1C21A 4B28A 4IKSA 4U69A 1PV9A 2P99A 1A16A 1MATA 1C22A 2ZSGA 2B3KA 2Q92A 5JFRA 3BITA 4EGEA 3L24A 4OOKA 2GGBA 5E5BA 2IW2A 2DFIA 2ADUA 2Q94A 1KQ0A 2G6PA 2BWWA 3BIQA 3PKAA 2HOWA 2BHCA 4ZNGA 1CHMA 4S01A 5D6FA 1WY2A 1QXYA 5JI6A 5CDLA 1YW8A 2P98A 1Y1NA 2GG5A 1XGOA 1B59A 3MR1A 4A6VA 2BN7A 1WKMA 3PKEA 5JHUA 1WLRA 3IU7A 4U76A 4IPAA 2NQ7A 3PKBA 4FKCA 4U73A 2EVMA 4IKUA 4U6JA 2OKNA 4FLKA 2GU4A 4IKRA 1R58A 1XNZA 3PKDA 4FLJA 1YW9A 4FLIA 2Q93A 4S2TP 1M35A 2BH3A 3TB5A 1N51A 2BHBA 2BWUA 1C24A 2GG3A 2GG8A 3RVAA 4ZWPA 1R5HA 3IU9A 2BWVA 4HXXA 2GU6A 3BIPA 1YVMA 4IKTA 1KP0A 2EVOA 3D27A 4KM3A 1XGNA 4JUQA 3S6BA 4U6EA 2GA2A 1WL6A 4U6ZA 5D6EA 5CNXA 4U6CA 2MATA 1C23A 2Q8KA 2B3LA 2GTXA 3Q6DA 1BN5A 1O0XA 2V3YA 4IF7A 5FCHA 1YW7A 4RGZ1 2EA2A 2GZ5A 1XGSA 4U1BA 4R60A 4U71A 5CDEA 3IG4A 4RZYA 4ZWUA 1QXZA 3FMRA 4PV4A 4FUKA 4MATA 1W2MA 1WN1A 2GU7A 4RZZA 4S2RP 3TAVA 2B3HA 2GGCA 2V3ZA 1R5GA 4FO7A 4S00A 2NQ6A 4IU6A 2P9AA 3FMQA 4Z7MA 1WBQA 2GG2A 2GG9A 1XGMA 2BWYA 3L7GA 5CLSA 2EA4A 2GG7A 2OAZA 4U75A 2Q95A 2BWXA 1KQ9A 2BB7A 4PNCA 1QZYA 1QXWA 1WL9A 4U6WA 4ZWOA 1B6AA 3FM3A 2BWSA 2V6CA 2BHAA 1W7VA 3CB5A 4A6WA 3IU8A 3RORA 3PKCA 5CDVA 2GU5A 4U70A 2Q96A 2V3XA 1JAWA 4IDYA 5CE6A 2BWTA 1YJ3A 3MX6A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3CB6 A;  1C27 A;  4IEC A;  4FO8 A;  4QR8 A;  5FCF A;  5CIK A;  1BOA A;  3CTZ A;  2EVC A;  3MAT A;  2GG0 A;  4FLL A;  2BHD A;  1C21 A;  4B28 A;  4IKS A;  4U69 A;  1PV9 A;  2P99 A;  1A16 A;  1MAT A;  1C22 A;  2ZSG A;  2B3K A;  2Q92 A;  5JFR A;  3BIT A;  4EGE A;  3L24 A;  4OOK A;  2GGB A;  5E5B A;  2IW2 A;  2DFI A;  2ADU A;  2Q94 A;  1KQ0 A;  2G6P A;  2BWW A;  3BIQ A;  3PKA A;  2HOW A;  2BHC A;  4ZNG A;  1CHM A;  4S01 A;  5D6F A;  1WY2 A;  1QXY A;  5JI6 A;  5CDL A;  1YW8 A;  2P98 A;  1Y1N A;  2GG5 A;  1XGO A;  1B59 A;  3MR1 A;  4A6V A;  2BN7 A;  1WKM A;  3PKE A;  5JHU A;  1WLR A;  3IU7 A;  4U76 A;  4IPA A;  2NQ7 A;  3PKB A;  4FKC A;  4U73 A;  2EVM A;  4IKU A;  4U6J A;  2OKN A;  4FLK A;  2GU4 A;  4IKR A;  1R58 A;  1XNZ A;  3PKD A;  4FLJ A;  1YW9 A;  4FLI A;  2Q93 A;  4S2T P;  1M35 A;  2BH3 A;  3TB5 A;  1N51 A;  2BHB A;  2BWU A;  1C24 A;  2GG3 A;  2GG8 A;  3RVA A;  4ZWP A;  1R5H A;  3IU9 A;  2BWV A;  4HXX A;  2GU6 A;  3BIP A;  1YVM A;  4IKT A;  1KP0 A;  2EVO A;  3D27 A;  4KM3 A;  1XGN A;  4JUQ A;  3S6B A;  4U6E A;  2GA2 A;  1WL6 A;  4U6Z A;  5D6E A;  5CNX A;  4U6C A;  2MAT A;  1C23 A;  2Q8K A;  2B3L A;  2GTX A;  3Q6D A;  1BN5 A;  1O0X A;  2V3Y A;  4IF7 A;  5FCH A;  1YW7 A;  4RGZ 1;  2EA2 A;  2GZ5 A;  1XGS A;  4U1B A;  4R60 A;  4U71 A;  5CDE A;  3IG4 A;  4RZY A;  4ZWU A;  1QXZ A;  3FMR A;  4PV4 A;  4FUK A;  4MAT A;  1W2M A;  1WN1 A;  2GU7 A;  4RZZ A;  4S2R P;  3TAV A;  2B3H A;  2GGC A;  2V3Z A;  1R5G A;  4FO7 A;  4S00 A;  2NQ6 A;  4IU6 A;  2P9A A;  3FMQ A;  4Z7M A;  1WBQ A;  2GG2 A;  2GG9 A;  1XGM A;  2BWY A;  3L7G A;  5CLS A;  2EA4 A;  2GG7 A;  2OAZ A;  4U75 A;  2Q95 A;  2BWX A;  1KQ9 A;  2BB7 A;  4PNC A;  1QZY A;  1QXW A;  1WL9 A;  4U6W A;  4ZWO A;  1B6A A;  3FM3 A;  2BWS A;  2V6C A;  2BHA A;  1W7V A;  3CB5 A;  4A6W A;  3IU8 A;  3ROR A;  3PKC A;  5CDV A;  2GU5 A;  4U70 A;  2Q96 A;  2V3X A;  1JAW A;  4IDY A;  5CE6 A;  2BWT A;  1YJ3 A;  3MX6 A; 
#chains in the Genus database with same CATH topology
 3CB6 A;  1C27 A;  4IEC A;  4FO8 A;  4QR8 A;  5FCF A;  5CIK A;  1BOA A;  3CTZ A;  2EVC A;  3MAT A;  2GG0 A;  4FLL A;  2BHD A;  1C21 A;  4B28 A;  4IKS A;  4U69 A;  1PV9 A;  2P99 A;  1A16 A;  1MAT A;  1C22 A;  2ZSG A;  2B3K A;  2Q92 A;  5JFR A;  3BIT A;  4EGE A;  3L24 A;  4OOK A;  2GGB A;  5E5B A;  2IW2 A;  2DFI A;  2ADU A;  2Q94 A;  1KQ0 A;  2G6P A;  2BWW A;  3BIQ A;  3PKA A;  2HOW A;  2BHC A;  4ZNG A;  1CHM A;  4S01 A;  5D6F A;  1WY2 A;  1QXY A;  5JI6 A;  5CDL A;  1YW8 A;  2P98 A;  1Y1N A;  2GG5 A;  1XGO A;  1B59 A;  3MR1 A;  4A6V A;  2BN7 A;  1WKM A;  3PKE A;  5JHU A;  1WLR A;  3IU7 A;  4U76 A;  4IPA A;  2NQ7 A;  3PKB A;  4FKC A;  4U73 A;  2EVM A;  4IKU A;  4U6J A;  2OKN A;  4FLK A;  2GU4 A;  4IKR A;  1R58 A;  1XNZ A;  3PKD A;  4FLJ A;  1YW9 A;  4FLI A;  2Q93 A;  4S2T P;  1M35 A;  2BH3 A;  3TB5 A;  1N51 A;  2BHB A;  2BWU A;  1C24 A;  2GG3 A;  2GG8 A;  3RVA A;  4ZWP A;  1R5H A;  3IU9 A;  2BWV A;  4HXX A;  2GU6 A;  3BIP A;  1YVM A;  4IKT A;  1KP0 A;  2EVO A;  3D27 A;  4KM3 A;  1XGN A;  4JUQ A;  3S6B A;  4U6E A;  2GA2 A;  1WL6 A;  4U6Z A;  5D6E A;  5CNX A;  4U6C A;  2MAT A;  1C23 A;  2Q8K A;  2B3L A;  2GTX A;  3Q6D A;  1BN5 A;  1O0X A;  2V3Y A;  4IF7 A;  5FCH A;  1YW7 A;  4RGZ 1;  2EA2 A;  2GZ5 A;  1XGS A;  4U1B A;  4R60 A;  4U71 A;  5CDE A;  3IG4 A;  4RZY A;  4ZWU A;  1QXZ A;  3FMR A;  4PV4 A;  4FUK A;  4MAT A;  1W2M A;  1WN1 A;  2GU7 A;  4RZZ A;  4S2R P;  3TAV A;  2B3H A;  2GGC A;  2V3Z A;  1R5G A;  4FO7 A;  4S00 A;  2NQ6 A;  4IU6 A;  2P9A A;  3FMQ A;  4Z7M A;  1WBQ A;  2GG2 A;  2GG9 A;  1XGM A;  2BWY A;  3L7G A;  5CLS A;  2EA4 A;  2GG7 A;  2OAZ A;  4U75 A;  2Q95 A;  2BWX A;  1KQ9 A;  2BB7 A;  4PNC A;  1QZY A;  1QXW A;  1WL9 A;  4U6W A;  4ZWO A;  1B6A A;  3FM3 A;  2BWS A;  2V6C A;  2BHA A;  1W7V A;  3CB5 A;  4A6W A;  3IU8 A;  3ROR A;  3PKC A;  5CDV A;  2GU5 A;  4U70 A;  2Q96 A;  2V3X A;  1JAW A;  4IDY A;  5CE6 A;  2BWT A;  1YJ3 A;  3MX6 A; 
#chains in the Genus database with same CATH homology
 3CB6 A;  1C27 A;  4IEC A;  4FO8 A;  4QR8 A;  5FCF A;  5CIK A;  1BOA A;  3CTZ A;  2EVC A;  3MAT A;  2GG0 A;  4FLL A;  2BHD A;  1C21 A;  4B28 A;  4IKS A;  4U69 A;  1PV9 A;  2P99 A;  1A16 A;  1MAT A;  1C22 A;  2ZSG A;  2B3K A;  2Q92 A;  5JFR A;  3BIT A;  4EGE A;  3L24 A;  4OOK A;  2GGB A;  5E5B A;  2IW2 A;  2DFI A;  2ADU A;  2Q94 A;  1KQ0 A;  2G6P A;  2BWW A;  3BIQ A;  3PKA A;  2HOW A;  2BHC A;  4ZNG A;  1CHM A;  4S01 A;  5D6F A;  1WY2 A;  1QXY A;  5JI6 A;  5CDL A;  1YW8 A;  2P98 A;  1Y1N A;  2GG5 A;  1XGO A;  1B59 A;  3MR1 A;  4A6V A;  2BN7 A;  1WKM A;  3PKE A;  5JHU A;  1WLR A;  3IU7 A;  4U76 A;  4IPA A;  2NQ7 A;  3PKB A;  4FKC A;  4U73 A;  2EVM A;  4IKU A;  4U6J A;  2OKN A;  4FLK A;  2GU4 A;  4IKR A;  1R58 A;  1XNZ A;  3PKD A;  4FLJ A;  1YW9 A;  4FLI A;  2Q93 A;  4S2T P;  1M35 A;  2BH3 A;  3TB5 A;  1N51 A;  2BHB A;  2BWU A;  1C24 A;  2GG3 A;  2GG8 A;  3RVA A;  4ZWP A;  1R5H A;  3IU9 A;  2BWV A;  4HXX A;  2GU6 A;  3BIP A;  1YVM A;  4IKT A;  1KP0 A;  2EVO A;  3D27 A;  4KM3 A;  1XGN A;  4JUQ A;  3S6B A;  4U6E A;  2GA2 A;  1WL6 A;  4U6Z A;  5D6E A;  5CNX A;  4U6C A;  2MAT A;  1C23 A;  2Q8K A;  2B3L A;  2GTX A;  3Q6D A;  1BN5 A;  1O0X A;  2V3Y A;  4IF7 A;  5FCH A;  1YW7 A;  4RGZ 1;  2EA2 A;  2GZ5 A;  1XGS A;  4U1B A;  4R60 A;  4U71 A;  5CDE A;  3IG4 A;  4RZY A;  4ZWU A;  1QXZ A;  3FMR A;  4PV4 A;  4FUK A;  4MAT A;  1W2M A;  1WN1 A;  2GU7 A;  4RZZ A;  4S2R P;  3TAV A;  2B3H A;  2GGC A;  2V3Z A;  1R5G A;  4FO7 A;  4S00 A;  2NQ6 A;  4IU6 A;  2P9A A;  3FMQ A;  4Z7M A;  1WBQ A;  2GG2 A;  2GG9 A;  1XGM A;  2BWY A;  3L7G A;  5CLS A;  2EA4 A;  2GG7 A;  2OAZ A;  4U75 A;  2Q95 A;  2BWX A;  1KQ9 A;  2BB7 A;  4PNC A;  1QZY A;  1QXW A;  1WL9 A;  4U6W A;  4ZWO A;  1B6A A;  3FM3 A;  2BWS A;  2V6C A;  2BHA A;  1W7V A;  3CB5 A;  4A6W A;  3IU8 A;  3ROR A;  3PKC A;  5CDV A;  2GU5 A;  4U70 A;  2Q96 A;  2V3X A;  1JAW A;  4IDY A;  5CE6 A;  2BWT A;  1YJ3 A;  3MX6 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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