4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase
source organism Homo sapiens
publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
4OOKA 4ZNGA 2B3KA 4IKTA 1M35A 1PV9A 1KQ0A 1R5GA 4PNCA 5JI6A 4QR8A 2Q93A 5JFRA 2BH3A 4U6CA 2EA4A 2ZSGA 2BWXA 4RGZ1 3S6BA 1YVMA 1XGOA 2BHAA 2GG9A 5CDVA 5FCFA 3IU8A 3PKDA 4KM3A 3MATA 3BIQA 2DFIA 3BIPA 2Q94A 5JHUA 3CB6A 4FLIA 2GU7A 1XGMA 1Y1NA 1QZYA 1KQ9A 2GG7A 4IKSA 1CHMA 1WBQA 4MATA 5FCHA 5CIKA 2BWUA 1C27A 3RVAA 2BHBA 3CB5A 2BWSA 2BHDA 2BWWA 3FMRA 4RZZA 3RORA 4U6EA 3FM3A 2GG8A 4S2RP 3PKBA 4EGEA 4S01A 3PKCA 1C24A 2EVCA 2GU6A 1W7VA 1O0XA 2Q96A 3L7GA 2BWTA 2B3HA 4S2TP 2GGCA 2GU4A 2EA2A 4JUQA 2EVMA 4U6JA 1C21A 2BN7A 2P9AA 4U6ZA 2GGBA 2GG5A 4IKRA 1YW9A 3IG4A 4U76A 1C23A 2BB7A 1N51A 4PV4A 4ZWPA 1XGSA 2Q95A 3TB5A 3BITA 5CDLA 1YJ3A 4U69A 2ADUA 3CTZA 4IU6A 3PKEA 1C22A 1YW8A 4U71A 2G6PA 2BHCA 4FO7A 5CNXA 4FKCA 1KP0A 2V3XA 3IU9A 4U1BA 1WL6A 2MATA 5E5BA 1A16A 2BWVA 4U70A 1QXZA 1WL9A 5D6FA 5CE6A 4IECA 1B6AA 1WN1A 2Q8KA 1BOAA 3MX6A 2GG3A 1W2MA 2GG0A 5D6EA 4U73A 4RZYA 4A6WA 4U75A 4ZWUA 2V3YA 3FMQA 2P99A 5CLSA 4R60A 4IF7A 4IPAA 2B3LA 4ZWOA 1BN5A 4HXXA 3TAVA 2GG2A 4A6VA 2Q92A 2GU5A 2V6CA 4B28A 2HOWA 3Q6DA 2GZ5A 4FLKA 2IW2A 1WY2A 1JAWA 1QXWA 2NQ7A 5CDEA 3L24A 1R58A 2OKNA 1WLRA 4S00A 1B59A 4FUKA 2BWYA 4FLLA 4IDYA 2GA2A 4IKUA 1XNZA 2NQ6A 1YW7A 3D27A 3MR1A 3IU7A 1R5HA 2P98A 2V3ZA 1MATA 4U6WA 2GTXA 1XGNA 2OAZA 4Z7MA 4FO8A 1WKMA 3PKAA 4FLJA 2EVOA 1QXYA
chains in the Genus database with same CATH superfamily
4OOKA 4ZNGA 2B3KA 4IKTA 1M35A 1PV9A 1KQ0A 1R5GA 4PNCA 5JI6A 4QR8A 2Q93A 5JFRA 2BH3A 4U6CA 2EA4A 2ZSGA 2BWXA 4RGZ1 3S6BA 1YVMA 1XGOA 2BHAA 2GG9A 5CDVA 5FCFA 3IU8A 3PKDA 4KM3A 3MATA 3BIQA 2DFIA 3BIPA 2Q94A 5JHUA 3CB6A 4FLIA 2GU7A 1XGMA 1Y1NA 1QZYA 1KQ9A 2GG7A 4IKSA 1CHMA 1WBQA 4MATA 5FCHA 5CIKA 2BWUA 1C27A 3RVAA 2BHBA 3CB5A 2BWSA 2BHDA 2BWWA 3FMRA 4RZZA 3RORA 4U6EA 3FM3A 2GG8A 4S2RP 3PKBA 4EGEA 4S01A 3PKCA 1C24A 2EVCA 2GU6A 1W7VA 1O0XA 2Q96A 3L7GA 2BWTA 2B3HA 4S2TP 2GGCA 2GU4A 2EA2A 4JUQA 2EVMA 4U6JA 1C21A 2BN7A 2P9AA 4U6ZA 2GGBA 2GG5A 4IKRA 1YW9A 3IG4A 4U76A 1C23A 2BB7A 1N51A 4PV4A 4ZWPA 1XGSA 2Q95A 3TB5A 3BITA 5CDLA 1YJ3A 4U69A 2ADUA 3CTZA 4IU6A 3PKEA 1C22A 1YW8A 4U71A 2G6PA 2BHCA 4FO7A 5CNXA 4FKCA 1KP0A 2V3XA 3IU9A 4U1BA 1WL6A 2MATA 5E5BA 1A16A 2BWVA 4U70A 1QXZA 1WL9A 5D6FA 5CE6A 4IECA 1B6AA 1WN1A 2Q8KA 1BOAA 3MX6A 2GG3A 1W2MA 2GG0A 5D6EA 4U73A 4RZYA 4A6WA 4U75A 4ZWUA 2V3YA 3FMQA 2P99A 5CLSA 4R60A 4IF7A 4IPAA 2B3LA 4ZWOA 1BN5A 4HXXA 3TAVA 2GG2A 4A6VA 2Q92A 2GU5A 2V6CA 4B28A 2HOWA 3Q6DA 2GZ5A 4FLKA 2IW2A 1WY2A 1JAWA 1QXWA 2NQ7A 5CDEA 3L24A 1R58A 2OKNA 1WLRA 4S00A 1B59A 4FUKA 2BWYA 4FLLA 4IDYA 2GA2A 4IKUA 1XNZA 2NQ6A 1YW7A 3D27A 3MR1A 3IU7A 1R5HA 2P98A 2V3ZA 1MATA 4U6WA 2GTXA 1XGNA 2OAZA 4Z7MA 4FO8A 1WKMA 3PKAA 4FLJA 2EVOA 1QXYA
chains in the Genus database with same CATH topology
4OOKA 4ZNGA 2B3KA 4IKTA 1M35A 1PV9A 1KQ0A 1R5GA 4PNCA 5JI6A 4QR8A 2Q93A 5JFRA 2BH3A 4U6CA 2EA4A 2ZSGA 2BWXA 4RGZ1 3S6BA 1YVMA 1XGOA 2BHAA 2GG9A 5CDVA 5FCFA 3IU8A 3PKDA 4KM3A 3MATA 3BIQA 2DFIA 3BIPA 2Q94A 5JHUA 3CB6A 4FLIA 2GU7A 1XGMA 1Y1NA 1QZYA 1KQ9A 2GG7A 4IKSA 1CHMA 1WBQA 4MATA 5FCHA 5CIKA 2BWUA 1C27A 3RVAA 2BHBA 3CB5A 2BWSA 2BHDA 2BWWA 3FMRA 4RZZA 3RORA 4U6EA 3FM3A 2GG8A 4S2RP 3PKBA 4EGEA 4S01A 3PKCA 1C24A 2EVCA 2GU6A 1W7VA 1O0XA 2Q96A 3L7GA 2BWTA 2B3HA 4S2TP 2GGCA 2GU4A 2EA2A 4JUQA 2EVMA 4U6JA 1C21A 2BN7A 2P9AA 4U6ZA 2GGBA 2GG5A 4IKRA 1YW9A 3IG4A 4U76A 1C23A 2BB7A 1N51A 4PV4A 4ZWPA 1XGSA 2Q95A 3TB5A 3BITA 5CDLA 1YJ3A 4U69A 2ADUA 3CTZA 4IU6A 3PKEA 1C22A 1YW8A 4U71A 2G6PA 2BHCA 4FO7A 5CNXA 4FKCA 1KP0A 2V3XA 3IU9A 4U1BA 1WL6A 2MATA 5E5BA 1A16A 2BWVA 4U70A 1QXZA 1WL9A 5D6FA 5CE6A 4IECA 1B6AA 1WN1A 2Q8KA 1BOAA 3MX6A 2GG3A 1W2MA 2GG0A 5D6EA 4U73A 4RZYA 4A6WA 4U75A 4ZWUA 2V3YA 3FMQA 2P99A 5CLSA 4R60A 4IF7A 4IPAA 2B3LA 4ZWOA 1BN5A 4HXXA 3TAVA 2GG2A 4A6VA 2Q92A 2GU5A 2V6CA 4B28A 2HOWA 3Q6DA 2GZ5A 4FLKA 2IW2A 1WY2A 1JAWA 1QXWA 2NQ7A 5CDEA 3L24A 1R58A 2OKNA 1WLRA 4S00A 1B59A 4FUKA 2BWYA 4FLLA 4IDYA 2GA2A 4IKUA 1XNZA 2NQ6A 1YW7A 3D27A 3MR1A 3IU7A 1R5HA 2P98A 2V3ZA 1MATA 4U6WA 2GTXA 1XGNA 2OAZA 4Z7MA 4FO8A 1WKMA 3PKAA 4FLJA 2EVOA 1QXYA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4OOK A;  4ZNG A;  2B3K A;  4IKT A;  1M35 A;  1PV9 A;  1KQ0 A;  1R5G A;  4PNC A;  5JI6 A;  4QR8 A;  2Q93 A;  5JFR A;  2BH3 A;  4U6C A;  2EA4 A;  2ZSG A;  2BWX A;  4RGZ 1;  3S6B A;  1YVM A;  1XGO A;  2BHA A;  2GG9 A;  5CDV A;  5FCF A;  3IU8 A;  3PKD A;  4KM3 A;  3MAT A;  3BIQ A;  2DFI A;  3BIP A;  2Q94 A;  5JHU A;  3CB6 A;  4FLI A;  2GU7 A;  1XGM A;  1Y1N A;  1QZY A;  1KQ9 A;  2GG7 A;  4IKS A;  1CHM A;  1WBQ A;  4MAT A;  5FCH A;  5CIK A;  2BWU A;  1C27 A;  3RVA A;  2BHB A;  3CB5 A;  2BWS A;  2BHD A;  2BWW A;  3FMR A;  4RZZ A;  3ROR A;  4U6E A;  3FM3 A;  2GG8 A;  4S2R P;  3PKB A;  4EGE A;  4S01 A;  3PKC A;  1C24 A;  2EVC A;  2GU6 A;  1W7V A;  1O0X A;  2Q96 A;  3L7G A;  2BWT A;  2B3H A;  4S2T P;  2GGC A;  2GU4 A;  2EA2 A;  4JUQ A;  2EVM A;  4U6J A;  1C21 A;  2BN7 A;  2P9A A;  4U6Z A;  2GGB A;  2GG5 A;  4IKR A;  1YW9 A;  3IG4 A;  4U76 A;  1C23 A;  2BB7 A;  1N51 A;  4PV4 A;  4ZWP A;  1XGS A;  2Q95 A;  3TB5 A;  3BIT A;  5CDL A;  1YJ3 A;  4U69 A;  2ADU A;  3CTZ A;  4IU6 A;  3PKE A;  1C22 A;  1YW8 A;  4U71 A;  2G6P A;  2BHC A;  4FO7 A;  5CNX A;  4FKC A;  1KP0 A;  2V3X A;  3IU9 A;  4U1B A;  1WL6 A;  2MAT A;  5E5B A;  1A16 A;  2BWV A;  4U70 A;  1QXZ A;  1WL9 A;  5D6F A;  5CE6 A;  4IEC A;  1B6A A;  1WN1 A;  2Q8K A;  1BOA A;  3MX6 A;  2GG3 A;  1W2M A;  2GG0 A;  5D6E A;  4U73 A;  4RZY A;  4A6W A;  4U75 A;  4ZWU A;  2V3Y A;  3FMQ A;  2P99 A;  5CLS A;  4R60 A;  4IF7 A;  4IPA A;  2B3L A;  4ZWO A;  1BN5 A;  4HXX A;  3TAV A;  2GG2 A;  4A6V A;  2Q92 A;  2GU5 A;  2V6C A;  4B28 A;  2HOW A;  3Q6D A;  2GZ5 A;  4FLK A;  2IW2 A;  1WY2 A;  1JAW A;  1QXW A;  2NQ7 A;  5CDE A;  3L24 A;  1R58 A;  2OKN A;  1WLR A;  4S00 A;  1B59 A;  4FUK A;  2BWY A;  4FLL A;  4IDY A;  2GA2 A;  4IKU A;  1XNZ A;  2NQ6 A;  1YW7 A;  3D27 A;  3MR1 A;  3IU7 A;  1R5H A;  2P98 A;  2V3Z A;  1MAT A;  4U6W A;  2GTX A;  1XGN A;  2OAZ A;  4Z7M A;  4FO8 A;  1WKM A;  3PKA A;  4FLJ A;  2EVO A;  1QXY A; 
#chains in the Genus database with same CATH topology
 4OOK A;  4ZNG A;  2B3K A;  4IKT A;  1M35 A;  1PV9 A;  1KQ0 A;  1R5G A;  4PNC A;  5JI6 A;  4QR8 A;  2Q93 A;  5JFR A;  2BH3 A;  4U6C A;  2EA4 A;  2ZSG A;  2BWX A;  4RGZ 1;  3S6B A;  1YVM A;  1XGO A;  2BHA A;  2GG9 A;  5CDV A;  5FCF A;  3IU8 A;  3PKD A;  4KM3 A;  3MAT A;  3BIQ A;  2DFI A;  3BIP A;  2Q94 A;  5JHU A;  3CB6 A;  4FLI A;  2GU7 A;  1XGM A;  1Y1N A;  1QZY A;  1KQ9 A;  2GG7 A;  4IKS A;  1CHM A;  1WBQ A;  4MAT A;  5FCH A;  5CIK A;  2BWU A;  1C27 A;  3RVA A;  2BHB A;  3CB5 A;  2BWS A;  2BHD A;  2BWW A;  3FMR A;  4RZZ A;  3ROR A;  4U6E A;  3FM3 A;  2GG8 A;  4S2R P;  3PKB A;  4EGE A;  4S01 A;  3PKC A;  1C24 A;  2EVC A;  2GU6 A;  1W7V A;  1O0X A;  2Q96 A;  3L7G A;  2BWT A;  2B3H A;  4S2T P;  2GGC A;  2GU4 A;  2EA2 A;  4JUQ A;  2EVM A;  4U6J A;  1C21 A;  2BN7 A;  2P9A A;  4U6Z A;  2GGB A;  2GG5 A;  4IKR A;  1YW9 A;  3IG4 A;  4U76 A;  1C23 A;  2BB7 A;  1N51 A;  4PV4 A;  4ZWP A;  1XGS A;  2Q95 A;  3TB5 A;  3BIT A;  5CDL A;  1YJ3 A;  4U69 A;  2ADU A;  3CTZ A;  4IU6 A;  3PKE A;  1C22 A;  1YW8 A;  4U71 A;  2G6P A;  2BHC A;  4FO7 A;  5CNX A;  4FKC A;  1KP0 A;  2V3X A;  3IU9 A;  4U1B A;  1WL6 A;  2MAT A;  5E5B A;  1A16 A;  2BWV A;  4U70 A;  1QXZ A;  1WL9 A;  5D6F A;  5CE6 A;  4IEC A;  1B6A A;  1WN1 A;  2Q8K A;  1BOA A;  3MX6 A;  2GG3 A;  1W2M A;  2GG0 A;  5D6E A;  4U73 A;  4RZY A;  4A6W A;  4U75 A;  4ZWU A;  2V3Y A;  3FMQ A;  2P99 A;  5CLS A;  4R60 A;  4IF7 A;  4IPA A;  2B3L A;  4ZWO A;  1BN5 A;  4HXX A;  3TAV A;  2GG2 A;  4A6V A;  2Q92 A;  2GU5 A;  2V6C A;  4B28 A;  2HOW A;  3Q6D A;  2GZ5 A;  4FLK A;  2IW2 A;  1WY2 A;  1JAW A;  1QXW A;  2NQ7 A;  5CDE A;  3L24 A;  1R58 A;  2OKN A;  1WLR A;  4S00 A;  1B59 A;  4FUK A;  2BWY A;  4FLL A;  4IDY A;  2GA2 A;  4IKU A;  1XNZ A;  2NQ6 A;  1YW7 A;  3D27 A;  3MR1 A;  3IU7 A;  1R5H A;  2P98 A;  2V3Z A;  1MAT A;  4U6W A;  2GTX A;  1XGN A;  2OAZ A;  4Z7M A;  4FO8 A;  1WKM A;  3PKA A;  4FLJ A;  2EVO A;  1QXY A; 
#chains in the Genus database with same CATH homology
 4OOK A;  4ZNG A;  2B3K A;  4IKT A;  1M35 A;  1PV9 A;  1KQ0 A;  1R5G A;  4PNC A;  5JI6 A;  4QR8 A;  2Q93 A;  5JFR A;  2BH3 A;  4U6C A;  2EA4 A;  2ZSG A;  2BWX A;  4RGZ 1;  3S6B A;  1YVM A;  1XGO A;  2BHA A;  2GG9 A;  5CDV A;  5FCF A;  3IU8 A;  3PKD A;  4KM3 A;  3MAT A;  3BIQ A;  2DFI A;  3BIP A;  2Q94 A;  5JHU A;  3CB6 A;  4FLI A;  2GU7 A;  1XGM A;  1Y1N A;  1QZY A;  1KQ9 A;  2GG7 A;  4IKS A;  1CHM A;  1WBQ A;  4MAT A;  5FCH A;  5CIK A;  2BWU A;  1C27 A;  3RVA A;  2BHB A;  3CB5 A;  2BWS A;  2BHD A;  2BWW A;  3FMR A;  4RZZ A;  3ROR A;  4U6E A;  3FM3 A;  2GG8 A;  4S2R P;  3PKB A;  4EGE A;  4S01 A;  3PKC A;  1C24 A;  2EVC A;  2GU6 A;  1W7V A;  1O0X A;  2Q96 A;  3L7G A;  2BWT A;  2B3H A;  4S2T P;  2GGC A;  2GU4 A;  2EA2 A;  4JUQ A;  2EVM A;  4U6J A;  1C21 A;  2BN7 A;  2P9A A;  4U6Z A;  2GGB A;  2GG5 A;  4IKR A;  1YW9 A;  3IG4 A;  4U76 A;  1C23 A;  2BB7 A;  1N51 A;  4PV4 A;  4ZWP A;  1XGS A;  2Q95 A;  3TB5 A;  3BIT A;  5CDL A;  1YJ3 A;  4U69 A;  2ADU A;  3CTZ A;  4IU6 A;  3PKE A;  1C22 A;  1YW8 A;  4U71 A;  2G6P A;  2BHC A;  4FO7 A;  5CNX A;  4FKC A;  1KP0 A;  2V3X A;  3IU9 A;  4U1B A;  1WL6 A;  2MAT A;  5E5B A;  1A16 A;  2BWV A;  4U70 A;  1QXZ A;  1WL9 A;  5D6F A;  5CE6 A;  4IEC A;  1B6A A;  1WN1 A;  2Q8K A;  1BOA A;  3MX6 A;  2GG3 A;  1W2M A;  2GG0 A;  5D6E A;  4U73 A;  4RZY A;  4A6W A;  4U75 A;  4ZWU A;  2V3Y A;  3FMQ A;  2P99 A;  5CLS A;  4R60 A;  4IF7 A;  4IPA A;  2B3L A;  4ZWO A;  1BN5 A;  4HXX A;  3TAV A;  2GG2 A;  4A6V A;  2Q92 A;  2GU5 A;  2V6C A;  4B28 A;  2HOW A;  3Q6D A;  2GZ5 A;  4FLK A;  2IW2 A;  1WY2 A;  1JAW A;  1QXW A;  2NQ7 A;  5CDE A;  3L24 A;  1R58 A;  2OKN A;  1WLR A;  4S00 A;  1B59 A;  4FUK A;  2BWY A;  4FLL A;  4IDY A;  2GA2 A;  4IKU A;  1XNZ A;  2NQ6 A;  1YW7 A;  3D27 A;  3MR1 A;  3IU7 A;  1R5H A;  2P98 A;  2V3Z A;  1MAT A;  4U6W A;  2GTX A;  1XGN A;  2OAZ A;  4Z7M A;  4FO8 A;  1WKM A;  3PKA A;  4FLJ A;  2EVO A;  1QXY A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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