4U73A

Hsmetap(f309m) in complex with (amino(phenyl)methyl)phosphonic acid
Total Genus 99
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
99
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLMHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Identification of the Molecular Basis of Inhibitor Selectivity between the Human and Streptococcal Type I Methionine Aminopeptidases
pubmed doi rcsb
molecule keywords Methionine aminopeptidase 1
molecule tags Hydrolase
source organism Homo sapiens
total genus 99
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2014-07-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4u73A00
2V3XA 1XGNA 1BN5A 1WL9A 2GU6A 4U70A 4S00A 1XGMA 4FKCA 2P98A 3FM3A 3S6BA 2Q95A 5CIKA 1C21A 3MR1A 1XNZA 4IECA 2P99A 4IKRA 2IW2A 1YW8A 5D6EA 2DFIA 2EVMA 1KQ0A 3IG4A 3BITA 4ZNGA 2BWVA 5E5BA 3BIQA 2GU7A 3CB6A 1YW9A 4B28A 1R5GA 1Y1NA 1B6AA 4U71A 3RORA 2OKNA 4U76A 4IKTA 1QZYA 4U6CA 1MATA 2GG0A 1W2MA 3FMRA 1WBQA 5JFRA 4PNCA 4KM3A 5JI6A 4A6VA 1C22A 1YW7A 4U6WA 2Q92A 1WKMA 4HXXA 1WN1A 2B3KA 1M35A 3IU8A 1R5HA 2GG7A 2BWUA 2MATA 1QXYA 1WLRA 5FCFA 2EA2A 3MX6A 4A6WA 2GU4A 1CHMA 2ADUA 4IPAA 5CNXA 5FCHA 4ZWOA 2GG5A 4S01A 4IKSA 4U73A 2BH3A 2HOWA 4IU6A 4JUQA 1KQ9A 4QR8A 4S2RP 1W7VA 1C27A 2BWWA 1QXZA 4U75A 3CTZA 2Q8KA 2Q93A 5CDEA 1B59A 4FUKA 1WL6A 2GU5A 1XGOA 3IU7A 2GG2A 2NQ6A 3PKBA 4ZWUA 2EA4A 2BN7A 3PKEA 2P9AA 2BHDA 2BWYA 4IDYA 4U6EA 1R58A 4RGZ1 2BHAA 5D6FA 4IF7A 4ZWPA 3L24A 1N51A 5CE6A 4PV4A 3PKAA 4FLLA 1O0XA 1A16A 2GA2A 1KP0A 3PKDA 5CDVA 3PKCA 4U69A 4OOKA 1JAWA 2G6PA 3L7GA 2EVCA 1C23A 3MATA 2GG8A 3TB5A 1C24A 1QXWA 3TAVA 5CDLA 5CLSA 2Q96A 4FLJA 2OAZA 5JHUA 2EVOA 4R60A 2GTXA 2BHBA 3BIPA 3RVAA 4MATA 2GGBA 2BHCA 2V3YA 2GG9A 1XGSA 2BB7A 3IU9A 3CB5A 4FLIA 2GZ5A 2V6CA 2GGCA 3Q6DA 4FLKA 4FO7A 2V3ZA 3FMQA 1YVMA 2B3HA 2GG3A 2Q94A 1YJ3A 4U1BA 4EGEA 2BWXA 4Z7MA 4U6JA 4IKUA 2BWTA 4RZZA 2NQ7A 4S2TP 2ZSGA 2BWSA 4U6ZA 1PV9A 1WY2A 3D27A 4RZYA 4FO8A 2B3LA 1BOAA
chains in the Genus database with same CATH superfamily
2V3XA 1XGNA 1BN5A 1WL9A 2GU6A 4U70A 4S00A 1XGMA 4FKCA 2P98A 3FM3A 3S6BA 2Q95A 5CIKA 1C21A 3MR1A 1XNZA 4IECA 2P99A 4IKRA 2IW2A 1YW8A 5D6EA 2DFIA 2EVMA 1KQ0A 3IG4A 3BITA 4ZNGA 2BWVA 5E5BA 3BIQA 2GU7A 3CB6A 1YW9A 4B28A 1R5GA 1Y1NA 1B6AA 4U71A 3RORA 2OKNA 4U76A 4IKTA 1QZYA 4U6CA 1MATA 2GG0A 1W2MA 3FMRA 1WBQA 5JFRA 4PNCA 4KM3A 5JI6A 4A6VA 1C22A 1YW7A 4U6WA 2Q92A 1WKMA 4HXXA 1WN1A 2B3KA 1M35A 3IU8A 1R5HA 2GG7A 2BWUA 2MATA 1QXYA 1WLRA 5FCFA 2EA2A 3MX6A 4A6WA 2GU4A 1CHMA 2ADUA 4IPAA 5CNXA 5FCHA 4ZWOA 2GG5A 4S01A 4IKSA 4U73A 2BH3A 2HOWA 4IU6A 4JUQA 1KQ9A 4QR8A 4S2RP 1W7VA 1C27A 2BWWA 1QXZA 4U75A 3CTZA 2Q8KA 2Q93A 5CDEA 1B59A 4FUKA 1WL6A 2GU5A 1XGOA 3IU7A 2GG2A 2NQ6A 3PKBA 4ZWUA 2EA4A 2BN7A 3PKEA 2P9AA 2BHDA 2BWYA 4IDYA 4U6EA 1R58A 4RGZ1 2BHAA 5D6FA 4IF7A 4ZWPA 3L24A 1N51A 5CE6A 4PV4A 3PKAA 4FLLA 1O0XA 1A16A 2GA2A 1KP0A 3PKDA 5CDVA 3PKCA 4U69A 4OOKA 1JAWA 2G6PA 3L7GA 2EVCA 1C23A 3MATA 2GG8A 3TB5A 1C24A 1QXWA 3TAVA 5CDLA 5CLSA 2Q96A 4FLJA 2OAZA 5JHUA 2EVOA 4R60A 2GTXA 2BHBA 3BIPA 3RVAA 4MATA 2GGBA 2BHCA 2V3YA 2GG9A 1XGSA 2BB7A 3IU9A 3CB5A 4FLIA 2GZ5A 2V6CA 2GGCA 3Q6DA 4FLKA 4FO7A 2V3ZA 3FMQA 1YVMA 2B3HA 2GG3A 2Q94A 1YJ3A 4U1BA 4EGEA 2BWXA 4Z7MA 4U6JA 4IKUA 2BWTA 4RZZA 2NQ7A 4S2TP 2ZSGA 2BWSA 4U6ZA 1PV9A 1WY2A 3D27A 4RZYA 4FO8A 2B3LA 1BOAA
chains in the Genus database with same CATH topology
2V3XA 1XGNA 1BN5A 1WL9A 2GU6A 4U70A 4S00A 1XGMA 4FKCA 2P98A 3FM3A 3S6BA 2Q95A 5CIKA 1C21A 3MR1A 1XNZA 4IECA 2P99A 4IKRA 2IW2A 1YW8A 5D6EA 2DFIA 2EVMA 1KQ0A 3IG4A 3BITA 4ZNGA 2BWVA 5E5BA 3BIQA 2GU7A 3CB6A 1YW9A 4B28A 1R5GA 1Y1NA 1B6AA 4U71A 3RORA 2OKNA 4U76A 4IKTA 1QZYA 4U6CA 1MATA 2GG0A 1W2MA 3FMRA 1WBQA 5JFRA 4PNCA 4KM3A 5JI6A 4A6VA 1C22A 1YW7A 4U6WA 2Q92A 1WKMA 4HXXA 1WN1A 2B3KA 1M35A 3IU8A 1R5HA 2GG7A 2BWUA 2MATA 1QXYA 1WLRA 5FCFA 2EA2A 3MX6A 4A6WA 2GU4A 1CHMA 2ADUA 4IPAA 5CNXA 5FCHA 4ZWOA 2GG5A 4S01A 4IKSA 4U73A 2BH3A 2HOWA 4IU6A 4JUQA 1KQ9A 4QR8A 4S2RP 1W7VA 1C27A 2BWWA 1QXZA 4U75A 3CTZA 2Q8KA 2Q93A 5CDEA 1B59A 4FUKA 1WL6A 2GU5A 1XGOA 3IU7A 2GG2A 2NQ6A 3PKBA 4ZWUA 2EA4A 2BN7A 3PKEA 2P9AA 2BHDA 2BWYA 4IDYA 4U6EA 1R58A 4RGZ1 2BHAA 5D6FA 4IF7A 4ZWPA 3L24A 1N51A 5CE6A 4PV4A 3PKAA 4FLLA 1O0XA 1A16A 2GA2A 1KP0A 3PKDA 5CDVA 3PKCA 4U69A 4OOKA 1JAWA 2G6PA 3L7GA 2EVCA 1C23A 3MATA 2GG8A 3TB5A 1C24A 1QXWA 3TAVA 5CDLA 5CLSA 2Q96A 4FLJA 2OAZA 5JHUA 2EVOA 4R60A 2GTXA 2BHBA 3BIPA 3RVAA 4MATA 2GGBA 2BHCA 2V3YA 2GG9A 1XGSA 2BB7A 3IU9A 3CB5A 4FLIA 2GZ5A 2V6CA 2GGCA 3Q6DA 4FLKA 4FO7A 2V3ZA 3FMQA 1YVMA 2B3HA 2GG3A 2Q94A 1YJ3A 4U1BA 4EGEA 2BWXA 4Z7MA 4U6JA 4IKUA 2BWTA 4RZZA 2NQ7A 4S2TP 2ZSGA 2BWSA 4U6ZA 1PV9A 1WY2A 3D27A 4RZYA 4FO8A 2B3LA 1BOAA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2V3X A;  1XGN A;  1BN5 A;  1WL9 A;  2GU6 A;  4U70 A;  4S00 A;  1XGM A;  4FKC A;  2P98 A;  3FM3 A;  3S6B A;  2Q95 A;  5CIK A;  1C21 A;  3MR1 A;  1XNZ A;  4IEC A;  2P99 A;  4IKR A;  2IW2 A;  1YW8 A;  5D6E A;  2DFI A;  2EVM A;  1KQ0 A;  3IG4 A;  3BIT A;  4ZNG A;  2BWV A;  5E5B A;  3BIQ A;  2GU7 A;  3CB6 A;  1YW9 A;  4B28 A;  1R5G A;  1Y1N A;  1B6A A;  4U71 A;  3ROR A;  2OKN A;  4U76 A;  4IKT A;  1QZY A;  4U6C A;  1MAT A;  2GG0 A;  1W2M A;  3FMR A;  1WBQ A;  5JFR A;  4PNC A;  4KM3 A;  5JI6 A;  4A6V A;  1C22 A;  1YW7 A;  4U6W A;  2Q92 A;  1WKM A;  4HXX A;  1WN1 A;  2B3K A;  1M35 A;  3IU8 A;  1R5H A;  2GG7 A;  2BWU A;  2MAT A;  1QXY A;  1WLR A;  5FCF A;  2EA2 A;  3MX6 A;  4A6W A;  2GU4 A;  1CHM A;  2ADU A;  4IPA A;  5CNX A;  5FCH A;  4ZWO A;  2GG5 A;  4S01 A;  4IKS A;  4U73 A;  2BH3 A;  2HOW A;  4IU6 A;  4JUQ A;  1KQ9 A;  4QR8 A;  4S2R P;  1W7V A;  1C27 A;  2BWW A;  1QXZ A;  4U75 A;  3CTZ A;  2Q8K A;  2Q93 A;  5CDE A;  1B59 A;  4FUK A;  1WL6 A;  2GU5 A;  1XGO A;  3IU7 A;  2GG2 A;  2NQ6 A;  3PKB A;  4ZWU A;  2EA4 A;  2BN7 A;  3PKE A;  2P9A A;  2BHD A;  2BWY A;  4IDY A;  4U6E A;  1R58 A;  4RGZ 1;  2BHA A;  5D6F A;  4IF7 A;  4ZWP A;  3L24 A;  1N51 A;  5CE6 A;  4PV4 A;  3PKA A;  4FLL A;  1O0X A;  1A16 A;  2GA2 A;  1KP0 A;  3PKD A;  5CDV A;  3PKC A;  4U69 A;  4OOK A;  1JAW A;  2G6P A;  3L7G A;  2EVC A;  1C23 A;  3MAT A;  2GG8 A;  3TB5 A;  1C24 A;  1QXW A;  3TAV A;  5CDL A;  5CLS A;  2Q96 A;  4FLJ A;  2OAZ A;  5JHU A;  2EVO A;  4R60 A;  2GTX A;  2BHB A;  3BIP A;  3RVA A;  4MAT A;  2GGB A;  2BHC A;  2V3Y A;  2GG9 A;  1XGS A;  2BB7 A;  3IU9 A;  3CB5 A;  4FLI A;  2GZ5 A;  2V6C A;  2GGC A;  3Q6D A;  4FLK A;  4FO7 A;  2V3Z A;  3FMQ A;  1YVM A;  2B3H A;  2GG3 A;  2Q94 A;  1YJ3 A;  4U1B A;  4EGE A;  2BWX A;  4Z7M A;  4U6J A;  4IKU A;  2BWT A;  4RZZ A;  2NQ7 A;  4S2T P;  2ZSG A;  2BWS A;  4U6Z A;  1PV9 A;  1WY2 A;  3D27 A;  4RZY A;  4FO8 A;  2B3L A;  1BOA A; 
#chains in the Genus database with same CATH topology
 2V3X A;  1XGN A;  1BN5 A;  1WL9 A;  2GU6 A;  4U70 A;  4S00 A;  1XGM A;  4FKC A;  2P98 A;  3FM3 A;  3S6B A;  2Q95 A;  5CIK A;  1C21 A;  3MR1 A;  1XNZ A;  4IEC A;  2P99 A;  4IKR A;  2IW2 A;  1YW8 A;  5D6E A;  2DFI A;  2EVM A;  1KQ0 A;  3IG4 A;  3BIT A;  4ZNG A;  2BWV A;  5E5B A;  3BIQ A;  2GU7 A;  3CB6 A;  1YW9 A;  4B28 A;  1R5G A;  1Y1N A;  1B6A A;  4U71 A;  3ROR A;  2OKN A;  4U76 A;  4IKT A;  1QZY A;  4U6C A;  1MAT A;  2GG0 A;  1W2M A;  3FMR A;  1WBQ A;  5JFR A;  4PNC A;  4KM3 A;  5JI6 A;  4A6V A;  1C22 A;  1YW7 A;  4U6W A;  2Q92 A;  1WKM A;  4HXX A;  1WN1 A;  2B3K A;  1M35 A;  3IU8 A;  1R5H A;  2GG7 A;  2BWU A;  2MAT A;  1QXY A;  1WLR A;  5FCF A;  2EA2 A;  3MX6 A;  4A6W A;  2GU4 A;  1CHM A;  2ADU A;  4IPA A;  5CNX A;  5FCH A;  4ZWO A;  2GG5 A;  4S01 A;  4IKS A;  4U73 A;  2BH3 A;  2HOW A;  4IU6 A;  4JUQ A;  1KQ9 A;  4QR8 A;  4S2R P;  1W7V A;  1C27 A;  2BWW A;  1QXZ A;  4U75 A;  3CTZ A;  2Q8K A;  2Q93 A;  5CDE A;  1B59 A;  4FUK A;  1WL6 A;  2GU5 A;  1XGO A;  3IU7 A;  2GG2 A;  2NQ6 A;  3PKB A;  4ZWU A;  2EA4 A;  2BN7 A;  3PKE A;  2P9A A;  2BHD A;  2BWY A;  4IDY A;  4U6E A;  1R58 A;  4RGZ 1;  2BHA A;  5D6F A;  4IF7 A;  4ZWP A;  3L24 A;  1N51 A;  5CE6 A;  4PV4 A;  3PKA A;  4FLL A;  1O0X A;  1A16 A;  2GA2 A;  1KP0 A;  3PKD A;  5CDV A;  3PKC A;  4U69 A;  4OOK A;  1JAW A;  2G6P A;  3L7G A;  2EVC A;  1C23 A;  3MAT A;  2GG8 A;  3TB5 A;  1C24 A;  1QXW A;  3TAV A;  5CDL A;  5CLS A;  2Q96 A;  4FLJ A;  2OAZ A;  5JHU A;  2EVO A;  4R60 A;  2GTX A;  2BHB A;  3BIP A;  3RVA A;  4MAT A;  2GGB A;  2BHC A;  2V3Y A;  2GG9 A;  1XGS A;  2BB7 A;  3IU9 A;  3CB5 A;  4FLI A;  2GZ5 A;  2V6C A;  2GGC A;  3Q6D A;  4FLK A;  4FO7 A;  2V3Z A;  3FMQ A;  1YVM A;  2B3H A;  2GG3 A;  2Q94 A;  1YJ3 A;  4U1B A;  4EGE A;  2BWX A;  4Z7M A;  4U6J A;  4IKU A;  2BWT A;  4RZZ A;  2NQ7 A;  4S2T P;  2ZSG A;  2BWS A;  4U6Z A;  1PV9 A;  1WY2 A;  3D27 A;  4RZY A;  4FO8 A;  2B3L A;  1BOA A; 
#chains in the Genus database with same CATH homology
 2V3X A;  1XGN A;  1BN5 A;  1WL9 A;  2GU6 A;  4U70 A;  4S00 A;  1XGM A;  4FKC A;  2P98 A;  3FM3 A;  3S6B A;  2Q95 A;  5CIK A;  1C21 A;  3MR1 A;  1XNZ A;  4IEC A;  2P99 A;  4IKR A;  2IW2 A;  1YW8 A;  5D6E A;  2DFI A;  2EVM A;  1KQ0 A;  3IG4 A;  3BIT A;  4ZNG A;  2BWV A;  5E5B A;  3BIQ A;  2GU7 A;  3CB6 A;  1YW9 A;  4B28 A;  1R5G A;  1Y1N A;  1B6A A;  4U71 A;  3ROR A;  2OKN A;  4U76 A;  4IKT A;  1QZY A;  4U6C A;  1MAT A;  2GG0 A;  1W2M A;  3FMR A;  1WBQ A;  5JFR A;  4PNC A;  4KM3 A;  5JI6 A;  4A6V A;  1C22 A;  1YW7 A;  4U6W A;  2Q92 A;  1WKM A;  4HXX A;  1WN1 A;  2B3K A;  1M35 A;  3IU8 A;  1R5H A;  2GG7 A;  2BWU A;  2MAT A;  1QXY A;  1WLR A;  5FCF A;  2EA2 A;  3MX6 A;  4A6W A;  2GU4 A;  1CHM A;  2ADU A;  4IPA A;  5CNX A;  5FCH A;  4ZWO A;  2GG5 A;  4S01 A;  4IKS A;  4U73 A;  2BH3 A;  2HOW A;  4IU6 A;  4JUQ A;  1KQ9 A;  4QR8 A;  4S2R P;  1W7V A;  1C27 A;  2BWW A;  1QXZ A;  4U75 A;  3CTZ A;  2Q8K A;  2Q93 A;  5CDE A;  1B59 A;  4FUK A;  1WL6 A;  2GU5 A;  1XGO A;  3IU7 A;  2GG2 A;  2NQ6 A;  3PKB A;  4ZWU A;  2EA4 A;  2BN7 A;  3PKE A;  2P9A A;  2BHD A;  2BWY A;  4IDY A;  4U6E A;  1R58 A;  4RGZ 1;  2BHA A;  5D6F A;  4IF7 A;  4ZWP A;  3L24 A;  1N51 A;  5CE6 A;  4PV4 A;  3PKA A;  4FLL A;  1O0X A;  1A16 A;  2GA2 A;  1KP0 A;  3PKD A;  5CDV A;  3PKC A;  4U69 A;  4OOK A;  1JAW A;  2G6P A;  3L7G A;  2EVC A;  1C23 A;  3MAT A;  2GG8 A;  3TB5 A;  1C24 A;  1QXW A;  3TAV A;  5CDL A;  5CLS A;  2Q96 A;  4FLJ A;  2OAZ A;  5JHU A;  2EVO A;  4R60 A;  2GTX A;  2BHB A;  3BIP A;  3RVA A;  4MAT A;  2GGB A;  2BHC A;  2V3Y A;  2GG9 A;  1XGS A;  2BB7 A;  3IU9 A;  3CB5 A;  4FLI A;  2GZ5 A;  2V6C A;  2GGC A;  3Q6D A;  4FLK A;  4FO7 A;  2V3Z A;  3FMQ A;  1YVM A;  2B3H A;  2GG3 A;  2Q94 A;  1YJ3 A;  4U1B A;  4EGE A;  2BWX A;  4Z7M A;  4U6J A;  4IKU A;  2BWT A;  4RZZ A;  2NQ7 A;  4S2T P;  2ZSG A;  2BWS A;  4U6Z A;  1PV9 A;  1WY2 A;  3D27 A;  4RZY A;  4FO8 A;  2B3L A;  1BOA A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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