4A6WA

X-ray structures of oxazole hydroxamate ecmetap-mn complexes
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Hydroxamic Acids as Potent Inhibitors of Fe(II) and Mn(II) E. Coli Methionine Aminopeptidase: Biological Activities and X-Ray Structures of Oxazole Hydroxamate-Ecmetap-Mn Complexes.
pubmed doi rcsb
molecule keywords METHIONINE AMINOPEPTIDASE
molecule tags Transferase
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2011-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4a6wA00
3IU9A 4B28A 3FMRA 5JHUA 2BN7A 1BN5A 3BIPA 4MATA 3S6BA 1KP0A 5JFRA 1QXZA 2G6PA 2OAZA 5CNXA 1YJ3A 3FM3A 4IKRA 1W2MA 1XGOA 2BHAA 4U73A 4FLJA 5CE6A 5E5BA 3IG4A 4ZWOA 4IKSA 2BWTA 4S00A 4U6JA 1B6AA 4U6EA 2HOWA 4ZWPA 3MX6A 2Q92A 2BWSA 4FLLA 4U75A 4U6ZA 2Q95A 1B59A 1WL9A 5CDLA 5FCFA 2OKNA 1JAWA 4Z7MA 1R5GA 3BIQA 1KQ9A 3TAVA 4A6WA 2ZSGA 1WKMA 4RGZ1 2P98A 4ZNGA 2EVMA 1R58A 2GGBA 2BWYA 3L24A 3FMQA 2GG2A 4IECA 2GG7A 5D6FA 3D27A 2GG0A 4S01A 4FKCA 2EVCA 1MATA 3PKEA 2EVOA 4FO8A 1C21A 1QZYA 2GG5A 3PKCA 1PV9A 2BWXA 1Y1NA 1WY2A 3PKAA 2Q94A 2V3YA 1C24A 2GU5A 4HXXA 1A16A 4R60A 3CB5A 5CLSA 4OOKA 4FLIA 3BITA 4FLKA 4U6WA 3MR1A 2Q8KA 2BH3A 1M35A 2GG9A 3PKBA 1YVMA 2GG8A 4IU6A 2MATA 4U71A 4FO7A 1N51A 1XGMA 2EA4A 5CDEA 4PNCA 5CIKA 2Q96A 2NQ6A 3IU7A 2B3LA 2GA2A 4U76A 1YW7A 5D6EA 2BWUA 4EGEA 1WLRA 2DFIA 2BB7A 1QXWA 2GU4A 2BHBA 2GG3A 4U69A 4IPAA 3IU8A 3Q6DA 2IW2A 3L7GA 4IF7A 1WBQA 4QR8A 4RZZA 5JI6A 2B3HA 4S2TP 1XGNA 5CDVA 4IDYA 1XNZA 2Q93A 2GTXA 1WN1A 2BWVA 2BHCA 2ADUA 2NQ7A 4U6CA 1XGSA 1W7VA 3CTZA 4IKTA 3PKDA 2GU7A 1C27A 4JUQA 4PV4A 1QXYA 4IKUA 3RVAA 2V3XA 4U1BA 4S2RP 2GU6A 4ZWUA 1BOAA 4U70A 1R5HA 2EA2A 2V3ZA 3TB5A 2B3KA 1CHMA 1WL6A 1C23A 1YW9A 2P9AA 3RORA 4A6VA 2P99A 2GZ5A 2V6CA 4RZYA 4FUKA 1YW8A 1O0XA 1C22A 2BWWA 3CB6A 4KM3A 3MATA 2BHDA 5FCHA 2GGCA 1KQ0A
chains in the Genus database with same CATH superfamily
3IU9A 4B28A 3FMRA 5JHUA 2BN7A 1BN5A 3BIPA 4MATA 3S6BA 1KP0A 5JFRA 1QXZA 2G6PA 2OAZA 5CNXA 1YJ3A 3FM3A 4IKRA 1W2MA 1XGOA 2BHAA 4U73A 4FLJA 5CE6A 5E5BA 3IG4A 4ZWOA 4IKSA 2BWTA 4S00A 4U6JA 1B6AA 4U6EA 2HOWA 4ZWPA 3MX6A 2Q92A 2BWSA 4FLLA 4U75A 4U6ZA 2Q95A 1B59A 1WL9A 5CDLA 5FCFA 2OKNA 1JAWA 4Z7MA 1R5GA 3BIQA 1KQ9A 3TAVA 4A6WA 2ZSGA 1WKMA 4RGZ1 2P98A 4ZNGA 2EVMA 1R58A 2GGBA 2BWYA 3L24A 3FMQA 2GG2A 4IECA 2GG7A 5D6FA 3D27A 2GG0A 4S01A 4FKCA 2EVCA 1MATA 3PKEA 2EVOA 4FO8A 1C21A 1QZYA 2GG5A 3PKCA 1PV9A 2BWXA 1Y1NA 1WY2A 3PKAA 2Q94A 2V3YA 1C24A 2GU5A 4HXXA 1A16A 4R60A 3CB5A 5CLSA 4OOKA 4FLIA 3BITA 4FLKA 4U6WA 3MR1A 2Q8KA 2BH3A 1M35A 2GG9A 3PKBA 1YVMA 2GG8A 4IU6A 2MATA 4U71A 4FO7A 1N51A 1XGMA 2EA4A 5CDEA 4PNCA 5CIKA 2Q96A 2NQ6A 3IU7A 2B3LA 2GA2A 4U76A 1YW7A 5D6EA 2BWUA 4EGEA 1WLRA 2DFIA 2BB7A 1QXWA 2GU4A 2BHBA 2GG3A 4U69A 4IPAA 3IU8A 3Q6DA 2IW2A 3L7GA 4IF7A 1WBQA 4QR8A 4RZZA 5JI6A 2B3HA 4S2TP 1XGNA 5CDVA 4IDYA 1XNZA 2Q93A 2GTXA 1WN1A 2BWVA 2BHCA 2ADUA 2NQ7A 4U6CA 1XGSA 1W7VA 3CTZA 4IKTA 3PKDA 2GU7A 1C27A 4JUQA 4PV4A 1QXYA 4IKUA 3RVAA 2V3XA 4U1BA 4S2RP 2GU6A 4ZWUA 1BOAA 4U70A 1R5HA 2EA2A 2V3ZA 3TB5A 2B3KA 1CHMA 1WL6A 1C23A 1YW9A 2P9AA 3RORA 4A6VA 2P99A 2GZ5A 2V6CA 4RZYA 4FUKA 1YW8A 1O0XA 1C22A 2BWWA 3CB6A 4KM3A 3MATA 2BHDA 5FCHA 2GGCA 1KQ0A
chains in the Genus database with same CATH topology
3IU9A 4B28A 3FMRA 5JHUA 2BN7A 1BN5A 3BIPA 4MATA 3S6BA 1KP0A 5JFRA 1QXZA 2G6PA 2OAZA 5CNXA 1YJ3A 3FM3A 4IKRA 1W2MA 1XGOA 2BHAA 4U73A 4FLJA 5CE6A 5E5BA 3IG4A 4ZWOA 4IKSA 2BWTA 4S00A 4U6JA 1B6AA 4U6EA 2HOWA 4ZWPA 3MX6A 2Q92A 2BWSA 4FLLA 4U75A 4U6ZA 2Q95A 1B59A 1WL9A 5CDLA 5FCFA 2OKNA 1JAWA 4Z7MA 1R5GA 3BIQA 1KQ9A 3TAVA 4A6WA 2ZSGA 1WKMA 4RGZ1 2P98A 4ZNGA 2EVMA 1R58A 2GGBA 2BWYA 3L24A 3FMQA 2GG2A 4IECA 2GG7A 5D6FA 3D27A 2GG0A 4S01A 4FKCA 2EVCA 1MATA 3PKEA 2EVOA 4FO8A 1C21A 1QZYA 2GG5A 3PKCA 1PV9A 2BWXA 1Y1NA 1WY2A 3PKAA 2Q94A 2V3YA 1C24A 2GU5A 4HXXA 1A16A 4R60A 3CB5A 5CLSA 4OOKA 4FLIA 3BITA 4FLKA 4U6WA 3MR1A 2Q8KA 2BH3A 1M35A 2GG9A 3PKBA 1YVMA 2GG8A 4IU6A 2MATA 4U71A 4FO7A 1N51A 1XGMA 2EA4A 5CDEA 4PNCA 5CIKA 2Q96A 2NQ6A 3IU7A 2B3LA 2GA2A 4U76A 1YW7A 5D6EA 2BWUA 4EGEA 1WLRA 2DFIA 2BB7A 1QXWA 2GU4A 2BHBA 2GG3A 4U69A 4IPAA 3IU8A 3Q6DA 2IW2A 3L7GA 4IF7A 1WBQA 4QR8A 4RZZA 5JI6A 2B3HA 4S2TP 1XGNA 5CDVA 4IDYA 1XNZA 2Q93A 2GTXA 1WN1A 2BWVA 2BHCA 2ADUA 2NQ7A 4U6CA 1XGSA 1W7VA 3CTZA 4IKTA 3PKDA 2GU7A 1C27A 4JUQA 4PV4A 1QXYA 4IKUA 3RVAA 2V3XA 4U1BA 4S2RP 2GU6A 4ZWUA 1BOAA 4U70A 1R5HA 2EA2A 2V3ZA 3TB5A 2B3KA 1CHMA 1WL6A 1C23A 1YW9A 2P9AA 3RORA 4A6VA 2P99A 2GZ5A 2V6CA 4RZYA 4FUKA 1YW8A 1O0XA 1C22A 2BWWA 3CB6A 4KM3A 3MATA 2BHDA 5FCHA 2GGCA 1KQ0A
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3IU9 A;  4B28 A;  3FMR A;  5JHU A;  2BN7 A;  1BN5 A;  3BIP A;  4MAT A;  3S6B A;  1KP0 A;  5JFR A;  1QXZ A;  2G6P A;  2OAZ A;  5CNX A;  1YJ3 A;  3FM3 A;  4IKR A;  1W2M A;  1XGO A;  2BHA A;  4U73 A;  4FLJ A;  5CE6 A;  5E5B A;  3IG4 A;  4ZWO A;  4IKS A;  2BWT A;  4S00 A;  4U6J A;  1B6A A;  4U6E A;  2HOW A;  4ZWP A;  3MX6 A;  2Q92 A;  2BWS A;  4FLL A;  4U75 A;  4U6Z A;  2Q95 A;  1B59 A;  1WL9 A;  5CDL A;  5FCF A;  2OKN A;  1JAW A;  4Z7M A;  1R5G A;  3BIQ A;  1KQ9 A;  3TAV A;  4A6W A;  2ZSG A;  1WKM A;  4RGZ 1;  2P98 A;  4ZNG A;  2EVM A;  1R58 A;  2GGB A;  2BWY A;  3L24 A;  3FMQ A;  2GG2 A;  4IEC A;  2GG7 A;  5D6F A;  3D27 A;  2GG0 A;  4S01 A;  4FKC A;  2EVC A;  1MAT A;  3PKE A;  2EVO A;  4FO8 A;  1C21 A;  1QZY A;  2GG5 A;  3PKC A;  1PV9 A;  2BWX A;  1Y1N A;  1WY2 A;  3PKA A;  2Q94 A;  2V3Y A;  1C24 A;  2GU5 A;  4HXX A;  1A16 A;  4R60 A;  3CB5 A;  5CLS A;  4OOK A;  4FLI A;  3BIT A;  4FLK A;  4U6W A;  3MR1 A;  2Q8K A;  2BH3 A;  1M35 A;  2GG9 A;  3PKB A;  1YVM A;  2GG8 A;  4IU6 A;  2MAT A;  4U71 A;  4FO7 A;  1N51 A;  1XGM A;  2EA4 A;  5CDE A;  4PNC A;  5CIK A;  2Q96 A;  2NQ6 A;  3IU7 A;  2B3L A;  2GA2 A;  4U76 A;  1YW7 A;  5D6E A;  2BWU A;  4EGE A;  1WLR A;  2DFI A;  2BB7 A;  1QXW A;  2GU4 A;  2BHB A;  2GG3 A;  4U69 A;  4IPA A;  3IU8 A;  3Q6D A;  2IW2 A;  3L7G A;  4IF7 A;  1WBQ A;  4QR8 A;  4RZZ A;  5JI6 A;  2B3H A;  4S2T P;  1XGN A;  5CDV A;  4IDY A;  1XNZ A;  2Q93 A;  2GTX A;  1WN1 A;  2BWV A;  2BHC A;  2ADU A;  2NQ7 A;  4U6C A;  1XGS A;  1W7V A;  3CTZ A;  4IKT A;  3PKD A;  2GU7 A;  1C27 A;  4JUQ A;  4PV4 A;  1QXY A;  4IKU A;  3RVA A;  2V3X A;  4U1B A;  4S2R P;  2GU6 A;  4ZWU A;  1BOA A;  4U70 A;  1R5H A;  2EA2 A;  2V3Z A;  3TB5 A;  2B3K A;  1CHM A;  1WL6 A;  1C23 A;  1YW9 A;  2P9A A;  3ROR A;  4A6V A;  2P99 A;  2GZ5 A;  2V6C A;  4RZY A;  4FUK A;  1YW8 A;  1O0X A;  1C22 A;  2BWW A;  3CB6 A;  4KM3 A;  3MAT A;  2BHD A;  5FCH A;  2GGC A;  1KQ0 A; 
#chains in the Genus database with same CATH topology
 3IU9 A;  4B28 A;  3FMR A;  5JHU A;  2BN7 A;  1BN5 A;  3BIP A;  4MAT A;  3S6B A;  1KP0 A;  5JFR A;  1QXZ A;  2G6P A;  2OAZ A;  5CNX A;  1YJ3 A;  3FM3 A;  4IKR A;  1W2M A;  1XGO A;  2BHA A;  4U73 A;  4FLJ A;  5CE6 A;  5E5B A;  3IG4 A;  4ZWO A;  4IKS A;  2BWT A;  4S00 A;  4U6J A;  1B6A A;  4U6E A;  2HOW A;  4ZWP A;  3MX6 A;  2Q92 A;  2BWS A;  4FLL A;  4U75 A;  4U6Z A;  2Q95 A;  1B59 A;  1WL9 A;  5CDL A;  5FCF A;  2OKN A;  1JAW A;  4Z7M A;  1R5G A;  3BIQ A;  1KQ9 A;  3TAV A;  4A6W A;  2ZSG A;  1WKM A;  4RGZ 1;  2P98 A;  4ZNG A;  2EVM A;  1R58 A;  2GGB A;  2BWY A;  3L24 A;  3FMQ A;  2GG2 A;  4IEC A;  2GG7 A;  5D6F A;  3D27 A;  2GG0 A;  4S01 A;  4FKC A;  2EVC A;  1MAT A;  3PKE A;  2EVO A;  4FO8 A;  1C21 A;  1QZY A;  2GG5 A;  3PKC A;  1PV9 A;  2BWX A;  1Y1N A;  1WY2 A;  3PKA A;  2Q94 A;  2V3Y A;  1C24 A;  2GU5 A;  4HXX A;  1A16 A;  4R60 A;  3CB5 A;  5CLS A;  4OOK A;  4FLI A;  3BIT A;  4FLK A;  4U6W A;  3MR1 A;  2Q8K A;  2BH3 A;  1M35 A;  2GG9 A;  3PKB A;  1YVM A;  2GG8 A;  4IU6 A;  2MAT A;  4U71 A;  4FO7 A;  1N51 A;  1XGM A;  2EA4 A;  5CDE A;  4PNC A;  5CIK A;  2Q96 A;  2NQ6 A;  3IU7 A;  2B3L A;  2GA2 A;  4U76 A;  1YW7 A;  5D6E A;  2BWU A;  4EGE A;  1WLR A;  2DFI A;  2BB7 A;  1QXW A;  2GU4 A;  2BHB A;  2GG3 A;  4U69 A;  4IPA A;  3IU8 A;  3Q6D A;  2IW2 A;  3L7G A;  4IF7 A;  1WBQ A;  4QR8 A;  4RZZ A;  5JI6 A;  2B3H A;  4S2T P;  1XGN A;  5CDV A;  4IDY A;  1XNZ A;  2Q93 A;  2GTX A;  1WN1 A;  2BWV A;  2BHC A;  2ADU A;  2NQ7 A;  4U6C A;  1XGS A;  1W7V A;  3CTZ A;  4IKT A;  3PKD A;  2GU7 A;  1C27 A;  4JUQ A;  4PV4 A;  1QXY A;  4IKU A;  3RVA A;  2V3X A;  4U1B A;  4S2R P;  2GU6 A;  4ZWU A;  1BOA A;  4U70 A;  1R5H A;  2EA2 A;  2V3Z A;  3TB5 A;  2B3K A;  1CHM A;  1WL6 A;  1C23 A;  1YW9 A;  2P9A A;  3ROR A;  4A6V A;  2P99 A;  2GZ5 A;  2V6C A;  4RZY A;  4FUK A;  1YW8 A;  1O0X A;  1C22 A;  2BWW A;  3CB6 A;  4KM3 A;  3MAT A;  2BHD A;  5FCH A;  2GGC A;  1KQ0 A; 
#chains in the Genus database with same CATH homology
 3IU9 A;  4B28 A;  3FMR A;  5JHU A;  2BN7 A;  1BN5 A;  3BIP A;  4MAT A;  3S6B A;  1KP0 A;  5JFR A;  1QXZ A;  2G6P A;  2OAZ A;  5CNX A;  1YJ3 A;  3FM3 A;  4IKR A;  1W2M A;  1XGO A;  2BHA A;  4U73 A;  4FLJ A;  5CE6 A;  5E5B A;  3IG4 A;  4ZWO A;  4IKS A;  2BWT A;  4S00 A;  4U6J A;  1B6A A;  4U6E A;  2HOW A;  4ZWP A;  3MX6 A;  2Q92 A;  2BWS A;  4FLL A;  4U75 A;  4U6Z A;  2Q95 A;  1B59 A;  1WL9 A;  5CDL A;  5FCF A;  2OKN A;  1JAW A;  4Z7M A;  1R5G A;  3BIQ A;  1KQ9 A;  3TAV A;  4A6W A;  2ZSG A;  1WKM A;  4RGZ 1;  2P98 A;  4ZNG A;  2EVM A;  1R58 A;  2GGB A;  2BWY A;  3L24 A;  3FMQ A;  2GG2 A;  4IEC A;  2GG7 A;  5D6F A;  3D27 A;  2GG0 A;  4S01 A;  4FKC A;  2EVC A;  1MAT A;  3PKE A;  2EVO A;  4FO8 A;  1C21 A;  1QZY A;  2GG5 A;  3PKC A;  1PV9 A;  2BWX A;  1Y1N A;  1WY2 A;  3PKA A;  2Q94 A;  2V3Y A;  1C24 A;  2GU5 A;  4HXX A;  1A16 A;  4R60 A;  3CB5 A;  5CLS A;  4OOK A;  4FLI A;  3BIT A;  4FLK A;  4U6W A;  3MR1 A;  2Q8K A;  2BH3 A;  1M35 A;  2GG9 A;  3PKB A;  1YVM A;  2GG8 A;  4IU6 A;  2MAT A;  4U71 A;  4FO7 A;  1N51 A;  1XGM A;  2EA4 A;  5CDE A;  4PNC A;  5CIK A;  2Q96 A;  2NQ6 A;  3IU7 A;  2B3L A;  2GA2 A;  4U76 A;  1YW7 A;  5D6E A;  2BWU A;  4EGE A;  1WLR A;  2DFI A;  2BB7 A;  1QXW A;  2GU4 A;  2BHB A;  2GG3 A;  4U69 A;  4IPA A;  3IU8 A;  3Q6D A;  2IW2 A;  3L7G A;  4IF7 A;  1WBQ A;  4QR8 A;  4RZZ A;  5JI6 A;  2B3H A;  4S2T P;  1XGN A;  5CDV A;  4IDY A;  1XNZ A;  2Q93 A;  2GTX A;  1WN1 A;  2BWV A;  2BHC A;  2ADU A;  2NQ7 A;  4U6C A;  1XGS A;  1W7V A;  3CTZ A;  4IKT A;  3PKD A;  2GU7 A;  1C27 A;  4JUQ A;  4PV4 A;  1QXY A;  4IKU A;  3RVA A;  2V3X A;  4U1B A;  4S2R P;  2GU6 A;  4ZWU A;  1BOA A;  4U70 A;  1R5H A;  2EA2 A;  2V3Z A;  3TB5 A;  2B3K A;  1CHM A;  1WL6 A;  1C23 A;  1YW9 A;  2P9A A;  3ROR A;  4A6V A;  2P99 A;  2GZ5 A;  2V6C A;  4RZY A;  4FUK A;  1YW8 A;  1O0X A;  1C22 A;  2BWW A;  3CB6 A;  4KM3 A;  3MAT A;  2BHD A;  5FCH A;  2GGC A;  1KQ0 A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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