4A6WA

X-ray structures of oxazole hydroxamate ecmetap-mn complexes
Total Genus 83
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
83
sequence length
262
structure length
262
Chain Sequence
AISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGQGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHD
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Hydroxamic Acids as Potent Inhibitors of Fe(II) and Mn(II) E. Coli Methionine Aminopeptidase: Biological Activities and X-Ray Structures of Oxazole Hydroxamate-Ecmetap-Mn Complexes.
pubmed doi rcsb
molecule tags Transferase
molecule keywords METHIONINE AMINOPEPTIDASE
total genus 83
structure length 262
sequence length 262
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2011-11-09

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4a6wA00
1YW9A 2Q92A 3CB6A 4S2RP 1JAWA 4FKCA 2BWXA 4IU6A 3RVAA 2GG7A 2MATA 2EVCA 1C21A 4IKUA 2OKNA 1KQ0A 2HOWA 5CDVA 1N51A 1W2MA 2DFIA 4RZZA 1BOAA 3BIPA 2IW2A 4U69A 2BWSA 2GGCA 2GU7A 5JI6A 4ZNGA 4U75A 5CDLA 5FCHA 1WN1A 1WL6A 2BWVA 1MATA 2EA2A 2GU4A 3BITA 4JUQA 1XNZA 2GU6A 3PKBA 1WY2A 1M35A 1PV9A 1WKMA 1KQ9A 2ADUA 3CTZA 4U6WA 5FCFA 2OAZA 2GG8A 2P9AA 4IKRA 2P99A 4ZWUA 4IKSA 3IU7A 2ZSGA 2BWUA 4S01A 4ZWPA 1XGMA 2Q96A 5CLSA 1YJ3A 1QZYA 4A6VA 3S6BA 3IG4A 3IU9A 1R58A 4FUKA 4IF7A 3FM3A 3MATA 2NQ7A 2BB7A 4U6CA 1WL9A 2BHDA 2B3LA 2GG0A 4KM3A 2GZ5A 4RGZ1 5CIKA 2Q93A 2B3KA 2GU5A 1B59A 2V3ZA 4B28A 1QXZA 2GGBA 1Y1NA 3BIQA 4U6ZA 1W7VA 2BWWA 1KP0A 3FMQA 1XGNA 2NQ6A 5CNXA 2V3YA 2EA4A 4RZYA 4S2TP 1C23A 2GG5A 5E5BA 2BN7A 4U73A 2Q94A 4S00A 3TB5A 4IDYA 2BWTA 2Q8KA 4PV4A 1R5HA 1YVMA 4HXXA 2V3XA 3MX6A 3IU8A 4QR8A 3CB5A 3FMRA 3D27A 5D6FA 1R5GA 5CDEA 5JHUA 3L7GA 4Z7MA 4U6JA 3TAVA 1XGSA 1O0XA 5CE6A 2B3HA 1A16A 4U1BA 4IPAA 3RORA 2BHCA 4U71A 4FLJA 3PKAA 4FLLA 1C27A 4FLIA 1CHMA 4IKTA 2GA2A 3MR1A 4FO7A 2EVMA 4ZWOA 2GG9A 2EVOA 2GG3A 3Q6DA 2Q95A 3PKCA 2G6PA 1XGOA 2P98A 3PKDA 2V6CA 4EGEA 5D6EA 1C22A 1B6AA 2BWYA 2BHAA 3L24A 1QXWA 1QXYA 1YW7A 4U6EA 3PKEA 4OOKA 4FLKA 1WBQA 4A6WA 1BN5A 4U76A 4IECA 2BH3A 2BHBA 4FO8A 1YW8A 4U70A 2GG2A 4R60A 5JFRA 2GTXA 1WLRA 1C24A 4MATA 4PNCA
chains in the Genus database with same CATH superfamily
1YW9A 2Q92A 3CB6A 4S2RP 1JAWA 4FKCA 2BWXA 4IU6A 3RVAA 2GG7A 2MATA 2EVCA 1C21A 4IKUA 2OKNA 1KQ0A 2HOWA 5CDVA 1N51A 1W2MA 2DFIA 4RZZA 1BOAA 3BIPA 2IW2A 4U69A 2BWSA 2GGCA 2GU7A 5JI6A 4ZNGA 4U75A 5CDLA 5FCHA 1WN1A 1WL6A 2BWVA 1MATA 2EA2A 2GU4A 3BITA 4JUQA 1XNZA 2GU6A 3PKBA 1WY2A 1M35A 1PV9A 1WKMA 1KQ9A 2ADUA 3CTZA 4U6WA 5FCFA 2OAZA 2GG8A 2P9AA 4IKRA 2P99A 4ZWUA 4IKSA 3IU7A 2ZSGA 2BWUA 4S01A 4ZWPA 1XGMA 2Q96A 5CLSA 1YJ3A 1QZYA 4A6VA 3S6BA 3IG4A 3IU9A 1R58A 4FUKA 4IF7A 3FM3A 3MATA 2NQ7A 2BB7A 4U6CA 1WL9A 2BHDA 2B3LA 2GG0A 4KM3A 2GZ5A 4RGZ1 5CIKA 2Q93A 2B3KA 2GU5A 1B59A 2V3ZA 4B28A 1QXZA 2GGBA 1Y1NA 3BIQA 4U6ZA 1W7VA 2BWWA 1KP0A 3FMQA 1XGNA 2NQ6A 5CNXA 2V3YA 2EA4A 4RZYA 4S2TP 1C23A 2GG5A 5E5BA 2BN7A 4U73A 2Q94A 4S00A 3TB5A 4IDYA 2BWTA 2Q8KA 4PV4A 1R5HA 1YVMA 4HXXA 2V3XA 3MX6A 3IU8A 4QR8A 3CB5A 3FMRA 3D27A 5D6FA 1R5GA 5CDEA 5JHUA 3L7GA 4Z7MA 4U6JA 3TAVA 1XGSA 1O0XA 5CE6A 2B3HA 1A16A 4U1BA 4IPAA 3RORA 2BHCA 4U71A 4FLJA 3PKAA 4FLLA 1C27A 4FLIA 1CHMA 4IKTA 2GA2A 3MR1A 4FO7A 2EVMA 4ZWOA 2GG9A 2EVOA 2GG3A 3Q6DA 2Q95A 3PKCA 2G6PA 1XGOA 2P98A 3PKDA 2V6CA 4EGEA 5D6EA 1C22A 1B6AA 2BWYA 2BHAA 3L24A 1QXWA 1QXYA 1YW7A 4U6EA 3PKEA 4OOKA 4FLKA 1WBQA 4A6WA 1BN5A 4U76A 4IECA 2BH3A 2BHBA 4FO8A 1YW8A 4U70A 2GG2A 4R60A 5JFRA 2GTXA 1WLRA 1C24A 4MATA 4PNCA
chains in the Genus database with same CATH topology
1YW9A 2Q92A 3CB6A 4S2RP 1JAWA 4FKCA 2BWXA 4IU6A 3RVAA 2GG7A 2MATA 2EVCA 1C21A 4IKUA 2OKNA 1KQ0A 2HOWA 5CDVA 1N51A 1W2MA 2DFIA 4RZZA 1BOAA 3BIPA 2IW2A 4U69A 2BWSA 2GGCA 2GU7A 5JI6A 4ZNGA 4U75A 5CDLA 5FCHA 1WN1A 1WL6A 2BWVA 1MATA 2EA2A 2GU4A 3BITA 4JUQA 1XNZA 2GU6A 3PKBA 1WY2A 1M35A 1PV9A 1WKMA 1KQ9A 2ADUA 3CTZA 4U6WA 5FCFA 2OAZA 2GG8A 2P9AA 4IKRA 2P99A 4ZWUA 4IKSA 3IU7A 2ZSGA 2BWUA 4S01A 4ZWPA 1XGMA 2Q96A 5CLSA 1YJ3A 1QZYA 4A6VA 3S6BA 3IG4A 3IU9A 1R58A 4FUKA 4IF7A 3FM3A 3MATA 2NQ7A 2BB7A 4U6CA 1WL9A 2BHDA 2B3LA 2GG0A 4KM3A 2GZ5A 4RGZ1 5CIKA 2Q93A 2B3KA 2GU5A 1B59A 2V3ZA 4B28A 1QXZA 2GGBA 1Y1NA 3BIQA 4U6ZA 1W7VA 2BWWA 1KP0A 3FMQA 1XGNA 2NQ6A 5CNXA 2V3YA 2EA4A 4RZYA 4S2TP 1C23A 2GG5A 5E5BA 2BN7A 4U73A 2Q94A 4S00A 3TB5A 4IDYA 2BWTA 2Q8KA 4PV4A 1R5HA 1YVMA 4HXXA 2V3XA 3MX6A 3IU8A 4QR8A 3CB5A 3FMRA 3D27A 5D6FA 1R5GA 5CDEA 5JHUA 3L7GA 4Z7MA 4U6JA 3TAVA 1XGSA 1O0XA 5CE6A 2B3HA 1A16A 4U1BA 4IPAA 3RORA 2BHCA 4U71A 4FLJA 3PKAA 4FLLA 1C27A 4FLIA 1CHMA 4IKTA 2GA2A 3MR1A 4FO7A 2EVMA 4ZWOA 2GG9A 2EVOA 2GG3A 3Q6DA 2Q95A 3PKCA 2G6PA 1XGOA 2P98A 3PKDA 2V6CA 4EGEA 5D6EA 1C22A 1B6AA 2BWYA 2BHAA 3L24A 1QXWA 1QXYA 1YW7A 4U6EA 3PKEA 4OOKA 4FLKA 1WBQA 4A6WA 1BN5A 4U76A 4IECA 2BH3A 2BHBA 4FO8A 1YW8A 4U70A 2GG2A 4R60A 5JFRA 2GTXA 1WLRA 1C24A 4MATA 4PNCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1YW9 A;  2Q92 A;  3CB6 A;  4S2R P;  1JAW A;  4FKC A;  2BWX A;  4IU6 A;  3RVA A;  2GG7 A;  2MAT A;  2EVC A;  1C21 A;  4IKU A;  2OKN A;  1KQ0 A;  2HOW A;  5CDV A;  1N51 A;  1W2M A;  2DFI A;  4RZZ A;  1BOA A;  3BIP A;  2IW2 A;  4U69 A;  2BWS A;  2GGC A;  2GU7 A;  5JI6 A;  4ZNG A;  4U75 A;  5CDL A;  5FCH A;  1WN1 A;  1WL6 A;  2BWV A;  1MAT A;  2EA2 A;  2GU4 A;  3BIT A;  4JUQ A;  1XNZ A;  2GU6 A;  3PKB A;  1WY2 A;  1M35 A;  1PV9 A;  1WKM A;  1KQ9 A;  2ADU A;  3CTZ A;  4U6W A;  5FCF A;  2OAZ A;  2GG8 A;  2P9A A;  4IKR A;  2P99 A;  4ZWU A;  4IKS A;  3IU7 A;  2ZSG A;  2BWU A;  4S01 A;  4ZWP A;  1XGM A;  2Q96 A;  5CLS A;  1YJ3 A;  1QZY A;  4A6V A;  3S6B A;  3IG4 A;  3IU9 A;  1R58 A;  4FUK A;  4IF7 A;  3FM3 A;  3MAT A;  2NQ7 A;  2BB7 A;  4U6C A;  1WL9 A;  2BHD A;  2B3L A;  2GG0 A;  4KM3 A;  2GZ5 A;  4RGZ 1;  5CIK A;  2Q93 A;  2B3K A;  2GU5 A;  1B59 A;  2V3Z A;  4B28 A;  1QXZ A;  2GGB A;  1Y1N A;  3BIQ A;  4U6Z A;  1W7V A;  2BWW A;  1KP0 A;  3FMQ A;  1XGN A;  2NQ6 A;  5CNX A;  2V3Y A;  2EA4 A;  4RZY A;  4S2T P;  1C23 A;  2GG5 A;  5E5B A;  2BN7 A;  4U73 A;  2Q94 A;  4S00 A;  3TB5 A;  4IDY A;  2BWT A;  2Q8K A;  4PV4 A;  1R5H A;  1YVM A;  4HXX A;  2V3X A;  3MX6 A;  3IU8 A;  4QR8 A;  3CB5 A;  3FMR A;  3D27 A;  5D6F A;  1R5G A;  5CDE A;  5JHU A;  3L7G A;  4Z7M A;  4U6J A;  3TAV A;  1XGS A;  1O0X A;  5CE6 A;  2B3H A;  1A16 A;  4U1B A;  4IPA A;  3ROR A;  2BHC A;  4U71 A;  4FLJ A;  3PKA A;  4FLL A;  1C27 A;  4FLI A;  1CHM A;  4IKT A;  2GA2 A;  3MR1 A;  4FO7 A;  2EVM A;  4ZWO A;  2GG9 A;  2EVO A;  2GG3 A;  3Q6D A;  2Q95 A;  3PKC A;  2G6P A;  1XGO A;  2P98 A;  3PKD A;  2V6C A;  4EGE A;  5D6E A;  1C22 A;  1B6A A;  2BWY A;  2BHA A;  3L24 A;  1QXW A;  1QXY A;  1YW7 A;  4U6E A;  3PKE A;  4OOK A;  4FLK A;  1WBQ A;  4A6W A;  1BN5 A;  4U76 A;  4IEC A;  2BH3 A;  2BHB A;  4FO8 A;  1YW8 A;  4U70 A;  2GG2 A;  4R60 A;  5JFR A;  2GTX A;  1WLR A;  1C24 A;  4MAT A;  4PNC A; 
#chains in the Genus database with same CATH topology
 1YW9 A;  2Q92 A;  3CB6 A;  4S2R P;  1JAW A;  4FKC A;  2BWX A;  4IU6 A;  3RVA A;  2GG7 A;  2MAT A;  2EVC A;  1C21 A;  4IKU A;  2OKN A;  1KQ0 A;  2HOW A;  5CDV A;  1N51 A;  1W2M A;  2DFI A;  4RZZ A;  1BOA A;  3BIP A;  2IW2 A;  4U69 A;  2BWS A;  2GGC A;  2GU7 A;  5JI6 A;  4ZNG A;  4U75 A;  5CDL A;  5FCH A;  1WN1 A;  1WL6 A;  2BWV A;  1MAT A;  2EA2 A;  2GU4 A;  3BIT A;  4JUQ A;  1XNZ A;  2GU6 A;  3PKB A;  1WY2 A;  1M35 A;  1PV9 A;  1WKM A;  1KQ9 A;  2ADU A;  3CTZ A;  4U6W A;  5FCF A;  2OAZ A;  2GG8 A;  2P9A A;  4IKR A;  2P99 A;  4ZWU A;  4IKS A;  3IU7 A;  2ZSG A;  2BWU A;  4S01 A;  4ZWP A;  1XGM A;  2Q96 A;  5CLS A;  1YJ3 A;  1QZY A;  4A6V A;  3S6B A;  3IG4 A;  3IU9 A;  1R58 A;  4FUK A;  4IF7 A;  3FM3 A;  3MAT A;  2NQ7 A;  2BB7 A;  4U6C A;  1WL9 A;  2BHD A;  2B3L A;  2GG0 A;  4KM3 A;  2GZ5 A;  4RGZ 1;  5CIK A;  2Q93 A;  2B3K A;  2GU5 A;  1B59 A;  2V3Z A;  4B28 A;  1QXZ A;  2GGB A;  1Y1N A;  3BIQ A;  4U6Z A;  1W7V A;  2BWW A;  1KP0 A;  3FMQ A;  1XGN A;  2NQ6 A;  5CNX A;  2V3Y A;  2EA4 A;  4RZY A;  4S2T P;  1C23 A;  2GG5 A;  5E5B A;  2BN7 A;  4U73 A;  2Q94 A;  4S00 A;  3TB5 A;  4IDY A;  2BWT A;  2Q8K A;  4PV4 A;  1R5H A;  1YVM A;  4HXX A;  2V3X A;  3MX6 A;  3IU8 A;  4QR8 A;  3CB5 A;  3FMR A;  3D27 A;  5D6F A;  1R5G A;  5CDE A;  5JHU A;  3L7G A;  4Z7M A;  4U6J A;  3TAV A;  1XGS A;  1O0X A;  5CE6 A;  2B3H A;  1A16 A;  4U1B A;  4IPA A;  3ROR A;  2BHC A;  4U71 A;  4FLJ A;  3PKA A;  4FLL A;  1C27 A;  4FLI A;  1CHM A;  4IKT A;  2GA2 A;  3MR1 A;  4FO7 A;  2EVM A;  4ZWO A;  2GG9 A;  2EVO A;  2GG3 A;  3Q6D A;  2Q95 A;  3PKC A;  2G6P A;  1XGO A;  2P98 A;  3PKD A;  2V6C A;  4EGE A;  5D6E A;  1C22 A;  1B6A A;  2BWY A;  2BHA A;  3L24 A;  1QXW A;  1QXY A;  1YW7 A;  4U6E A;  3PKE A;  4OOK A;  4FLK A;  1WBQ A;  4A6W A;  1BN5 A;  4U76 A;  4IEC A;  2BH3 A;  2BHB A;  4FO8 A;  1YW8 A;  4U70 A;  2GG2 A;  4R60 A;  5JFR A;  2GTX A;  1WLR A;  1C24 A;  4MAT A;  4PNC A; 
#chains in the Genus database with same CATH homology
 1YW9 A;  2Q92 A;  3CB6 A;  4S2R P;  1JAW A;  4FKC A;  2BWX A;  4IU6 A;  3RVA A;  2GG7 A;  2MAT A;  2EVC A;  1C21 A;  4IKU A;  2OKN A;  1KQ0 A;  2HOW A;  5CDV A;  1N51 A;  1W2M A;  2DFI A;  4RZZ A;  1BOA A;  3BIP A;  2IW2 A;  4U69 A;  2BWS A;  2GGC A;  2GU7 A;  5JI6 A;  4ZNG A;  4U75 A;  5CDL A;  5FCH A;  1WN1 A;  1WL6 A;  2BWV A;  1MAT A;  2EA2 A;  2GU4 A;  3BIT A;  4JUQ A;  1XNZ A;  2GU6 A;  3PKB A;  1WY2 A;  1M35 A;  1PV9 A;  1WKM A;  1KQ9 A;  2ADU A;  3CTZ A;  4U6W A;  5FCF A;  2OAZ A;  2GG8 A;  2P9A A;  4IKR A;  2P99 A;  4ZWU A;  4IKS A;  3IU7 A;  2ZSG A;  2BWU A;  4S01 A;  4ZWP A;  1XGM A;  2Q96 A;  5CLS A;  1YJ3 A;  1QZY A;  4A6V A;  3S6B A;  3IG4 A;  3IU9 A;  1R58 A;  4FUK A;  4IF7 A;  3FM3 A;  3MAT A;  2NQ7 A;  2BB7 A;  4U6C A;  1WL9 A;  2BHD A;  2B3L A;  2GG0 A;  4KM3 A;  2GZ5 A;  4RGZ 1;  5CIK A;  2Q93 A;  2B3K A;  2GU5 A;  1B59 A;  2V3Z A;  4B28 A;  1QXZ A;  2GGB A;  1Y1N A;  3BIQ A;  4U6Z A;  1W7V A;  2BWW A;  1KP0 A;  3FMQ A;  1XGN A;  2NQ6 A;  5CNX A;  2V3Y A;  2EA4 A;  4RZY A;  4S2T P;  1C23 A;  2GG5 A;  5E5B A;  2BN7 A;  4U73 A;  2Q94 A;  4S00 A;  3TB5 A;  4IDY A;  2BWT A;  2Q8K A;  4PV4 A;  1R5H A;  1YVM A;  4HXX A;  2V3X A;  3MX6 A;  3IU8 A;  4QR8 A;  3CB5 A;  3FMR A;  3D27 A;  5D6F A;  1R5G A;  5CDE A;  5JHU A;  3L7G A;  4Z7M A;  4U6J A;  3TAV A;  1XGS A;  1O0X A;  5CE6 A;  2B3H A;  1A16 A;  4U1B A;  4IPA A;  3ROR A;  2BHC A;  4U71 A;  4FLJ A;  3PKA A;  4FLL A;  1C27 A;  4FLI A;  1CHM A;  4IKT A;  2GA2 A;  3MR1 A;  4FO7 A;  2EVM A;  4ZWO A;  2GG9 A;  2EVO A;  2GG3 A;  3Q6D A;  2Q95 A;  3PKC A;  2G6P A;  1XGO A;  2P98 A;  3PKD A;  2V6C A;  4EGE A;  5D6E A;  1C22 A;  1B6A A;  2BWY A;  2BHA A;  3L24 A;  1QXW A;  1QXY A;  1YW7 A;  4U6E A;  3PKE A;  4OOK A;  4FLK A;  1WBQ A;  4A6W A;  1BN5 A;  4U76 A;  4IEC A;  2BH3 A;  2BHB A;  4FO8 A;  1YW8 A;  4U70 A;  2GG2 A;  4R60 A;  5JFR A;  2GTX A;  1WLR A;  1C24 A;  4MAT A;  4PNC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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