4FLLA

Human metap1 with bengamide analog yz6, in mn form
Total Genus 101
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
101
sequence length
304
structure length
304
Chain Sequence
YRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Methionine aminopeptidase 1
publication title Structural analysis of bengamide derivatives as inhibitors of methionine aminopeptidases.
pubmed doi rcsb
source organism Homo sapiens
total genus 101
structure length 304
sequence length 304
ec nomenclature ec 3.4.11.18: Methionyl aminopeptidase.
pdb deposition date 2012-06-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00557 Peptidase_M24 Metallopeptidase family M24
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.230.10 Alpha Beta Alpha-Beta Complex Creatine Amidinohydrolase Creatinase/methionine aminopeptidase superfamily 4fllA00
2Q94A 1C24A 4S00A 5CDVA 4U6CA 2GU4A 1WL9A 3MX6A 4IF7A 1PV9A 2GA2A 3RVAA 4S2TP 3IU9A 2BN7A 2GU6A 3S6BA 4MATA 1BN5A 4IU6A 5CDLA 4U69A 2BWXA 1KP0A 4JUQA 2BWTA 4A6VA 2EA4A 4RGZ1 3L7GA 1N51A 3TAVA 1WY2A 2GU5A 3FM3A 1R5HA 4FLIA 4QR8A 4U6JA 1KQ9A 3RORA 2B3HA 5CNXA 5FCHA 3IU7A 2EVMA 1C27A 2EVOA 2Q92A 3BIQA 4HXXA 1XGOA 2IW2A 2V3YA 3FMRA 1XGSA 1WLRA 3CB5A 1A16A 2BH3A 2EVCA 3BITA 4IDYA 4U71A 2GG2A 1Y1NA 4OOKA 3PKEA 3TB5A 2B3KA 4ZNGA 2V3ZA 1YJ3A 3MR1A 4R60A 2BWWA 2GU7A 1C21A 1WKMA 2BHAA 4U76A 2NQ7A 2P99A 4S01A 4U6WA 4U6EA 1W7VA 4IKTA 2GG8A 4U73A 4ZWOA 5CDEA 1XNZA 1M35A 1XGMA 3CTZA 2GG7A 2BWSA 1YW7A 1B6AA 2BB7A 2GGCA 4RZZA 5JFRA 1R58A 5E5BA 2GTXA 1WBQA 4IPAA 4S2RP 3FMQA 3MATA 2BWYA 1C23A 1YVMA 4U70A 3PKDA 3L24A 1O0XA 2ADUA 2G6PA 4EGEA 1WL6A 4KM3A 5JHUA 2GG9A 2B3LA 2BHDA 1BOAA 5CIKA 3IU8A 4PV4A 3Q6DA 5JI6A 2Q8KA 4B28A 4IKSA 1W2MA 2Q96A 4FLKA 4Z7MA 5D6FA 4A6WA 1B59A 2GZ5A 2P9AA 4FO7A 2Q95A 2NQ6A 4U75A 5D6EA 1JAWA 2V3XA 3IG4A 3D27A 1XGNA 4FLLA 2HOWA 3PKBA 2GG0A 2BWVA 2BWUA 1QXWA 2EA2A 2BHBA 1KQ0A 2P98A 4FUKA 4FLJA 2GG5A 4IECA 4IKRA 1R5GA 1YW8A 2MATA 4IKUA 4RZYA 4U1BA 5CLSA 3PKCA 3CB6A 2DFIA 2GG3A 3PKAA 4ZWUA 1QXYA 1C22A 1QXZA 1YW9A 1WN1A 2Q93A 2V6CA 2GGBA 1CHMA 4ZWPA 1MATA 2OKNA 1QZYA 3BIPA 4PNCA 2ZSGA 2BHCA 5CE6A 2OAZA 4U6ZA 4FO8A 5FCFA 4FKCA
chains in the Genus database with same CATH superfamily
2Q94A 1C24A 4S00A 5CDVA 4U6CA 2GU4A 1WL9A 3MX6A 4IF7A 1PV9A 2GA2A 3RVAA 4S2TP 3IU9A 2BN7A 2GU6A 3S6BA 4MATA 1BN5A 4IU6A 5CDLA 4U69A 2BWXA 1KP0A 4JUQA 2BWTA 4A6VA 2EA4A 4RGZ1 3L7GA 1N51A 3TAVA 1WY2A 2GU5A 3FM3A 1R5HA 4FLIA 4QR8A 4U6JA 1KQ9A 3RORA 2B3HA 5CNXA 5FCHA 3IU7A 2EVMA 1C27A 2EVOA 2Q92A 3BIQA 4HXXA 1XGOA 2IW2A 2V3YA 3FMRA 1XGSA 1WLRA 3CB5A 1A16A 2BH3A 2EVCA 3BITA 4IDYA 4U71A 2GG2A 1Y1NA 4OOKA 3PKEA 3TB5A 2B3KA 4ZNGA 2V3ZA 1YJ3A 3MR1A 4R60A 2BWWA 2GU7A 1C21A 1WKMA 2BHAA 4U76A 2NQ7A 2P99A 4S01A 4U6WA 4U6EA 1W7VA 4IKTA 2GG8A 4U73A 4ZWOA 5CDEA 1XNZA 1M35A 1XGMA 3CTZA 2GG7A 2BWSA 1YW7A 1B6AA 2BB7A 2GGCA 4RZZA 5JFRA 1R58A 5E5BA 2GTXA 1WBQA 4IPAA 4S2RP 3FMQA 3MATA 2BWYA 1C23A 1YVMA 4U70A 3PKDA 3L24A 1O0XA 2ADUA 2G6PA 4EGEA 1WL6A 4KM3A 5JHUA 2GG9A 2B3LA 2BHDA 1BOAA 5CIKA 3IU8A 4PV4A 3Q6DA 5JI6A 2Q8KA 4B28A 4IKSA 1W2MA 2Q96A 4FLKA 4Z7MA 5D6FA 4A6WA 1B59A 2GZ5A 2P9AA 4FO7A 2Q95A 2NQ6A 4U75A 5D6EA 1JAWA 2V3XA 3IG4A 3D27A 1XGNA 4FLLA 2HOWA 3PKBA 2GG0A 2BWVA 2BWUA 1QXWA 2EA2A 2BHBA 1KQ0A 2P98A 4FUKA 4FLJA 2GG5A 4IECA 4IKRA 1R5GA 1YW8A 2MATA 4IKUA 4RZYA 4U1BA 5CLSA 3PKCA 3CB6A 2DFIA 2GG3A 3PKAA 4ZWUA 1QXYA 1C22A 1QXZA 1YW9A 1WN1A 2Q93A 2V6CA 2GGBA 1CHMA 4ZWPA 1MATA 2OKNA 1QZYA 3BIPA 4PNCA 2ZSGA 2BHCA 5CE6A 2OAZA 4U6ZA 4FO8A 5FCFA 4FKCA
chains in the Genus database with same CATH topology
2Q94A 1C24A 4S00A 5CDVA 4U6CA 2GU4A 1WL9A 3MX6A 4IF7A 1PV9A 2GA2A 3RVAA 4S2TP 3IU9A 2BN7A 2GU6A 3S6BA 4MATA 1BN5A 4IU6A 5CDLA 4U69A 2BWXA 1KP0A 4JUQA 2BWTA 4A6VA 2EA4A 4RGZ1 3L7GA 1N51A 3TAVA 1WY2A 2GU5A 3FM3A 1R5HA 4FLIA 4QR8A 4U6JA 1KQ9A 3RORA 2B3HA 5CNXA 5FCHA 3IU7A 2EVMA 1C27A 2EVOA 2Q92A 3BIQA 4HXXA 1XGOA 2IW2A 2V3YA 3FMRA 1XGSA 1WLRA 3CB5A 1A16A 2BH3A 2EVCA 3BITA 4IDYA 4U71A 2GG2A 1Y1NA 4OOKA 3PKEA 3TB5A 2B3KA 4ZNGA 2V3ZA 1YJ3A 3MR1A 4R60A 2BWWA 2GU7A 1C21A 1WKMA 2BHAA 4U76A 2NQ7A 2P99A 4S01A 4U6WA 4U6EA 1W7VA 4IKTA 2GG8A 4U73A 4ZWOA 5CDEA 1XNZA 1M35A 1XGMA 3CTZA 2GG7A 2BWSA 1YW7A 1B6AA 2BB7A 2GGCA 4RZZA 5JFRA 1R58A 5E5BA 2GTXA 1WBQA 4IPAA 4S2RP 3FMQA 3MATA 2BWYA 1C23A 1YVMA 4U70A 3PKDA 3L24A 1O0XA 2ADUA 2G6PA 4EGEA 1WL6A 4KM3A 5JHUA 2GG9A 2B3LA 2BHDA 1BOAA 5CIKA 3IU8A 4PV4A 3Q6DA 5JI6A 2Q8KA 4B28A 4IKSA 1W2MA 2Q96A 4FLKA 4Z7MA 5D6FA 4A6WA 1B59A 2GZ5A 2P9AA 4FO7A 2Q95A 2NQ6A 4U75A 5D6EA 1JAWA 2V3XA 3IG4A 3D27A 1XGNA 4FLLA 2HOWA 3PKBA 2GG0A 2BWVA 2BWUA 1QXWA 2EA2A 2BHBA 1KQ0A 2P98A 4FUKA 4FLJA 2GG5A 4IECA 4IKRA 1R5GA 1YW8A 2MATA 4IKUA 4RZYA 4U1BA 5CLSA 3PKCA 3CB6A 2DFIA 2GG3A 3PKAA 4ZWUA 1QXYA 1C22A 1QXZA 1YW9A 1WN1A 2Q93A 2V6CA 2GGBA 1CHMA 4ZWPA 1MATA 2OKNA 1QZYA 3BIPA 4PNCA 2ZSGA 2BHCA 5CE6A 2OAZA 4U6ZA 4FO8A 5FCFA 4FKCA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 2Q94 A;  1C24 A;  4S00 A;  5CDV A;  4U6C A;  2GU4 A;  1WL9 A;  3MX6 A;  4IF7 A;  1PV9 A;  2GA2 A;  3RVA A;  4S2T P;  3IU9 A;  2BN7 A;  2GU6 A;  3S6B A;  4MAT A;  1BN5 A;  4IU6 A;  5CDL A;  4U69 A;  2BWX A;  1KP0 A;  4JUQ A;  2BWT A;  4A6V A;  2EA4 A;  4RGZ 1;  3L7G A;  1N51 A;  3TAV A;  1WY2 A;  2GU5 A;  3FM3 A;  1R5H A;  4FLI A;  4QR8 A;  4U6J A;  1KQ9 A;  3ROR A;  2B3H A;  5CNX A;  5FCH A;  3IU7 A;  2EVM A;  1C27 A;  2EVO A;  2Q92 A;  3BIQ A;  4HXX A;  1XGO A;  2IW2 A;  2V3Y A;  3FMR A;  1XGS A;  1WLR A;  3CB5 A;  1A16 A;  2BH3 A;  2EVC A;  3BIT A;  4IDY A;  4U71 A;  2GG2 A;  1Y1N A;  4OOK A;  3PKE A;  3TB5 A;  2B3K A;  4ZNG A;  2V3Z A;  1YJ3 A;  3MR1 A;  4R60 A;  2BWW A;  2GU7 A;  1C21 A;  1WKM A;  2BHA A;  4U76 A;  2NQ7 A;  2P99 A;  4S01 A;  4U6W A;  4U6E A;  1W7V A;  4IKT A;  2GG8 A;  4U73 A;  4ZWO A;  5CDE A;  1XNZ A;  1M35 A;  1XGM A;  3CTZ A;  2GG7 A;  2BWS A;  1YW7 A;  1B6A A;  2BB7 A;  2GGC A;  4RZZ A;  5JFR A;  1R58 A;  5E5B A;  2GTX A;  1WBQ A;  4IPA A;  4S2R P;  3FMQ A;  3MAT A;  2BWY A;  1C23 A;  1YVM A;  4U70 A;  3PKD A;  3L24 A;  1O0X A;  2ADU A;  2G6P A;  4EGE A;  1WL6 A;  4KM3 A;  5JHU A;  2GG9 A;  2B3L A;  2BHD A;  1BOA A;  5CIK A;  3IU8 A;  4PV4 A;  3Q6D A;  5JI6 A;  2Q8K A;  4B28 A;  4IKS A;  1W2M A;  2Q96 A;  4FLK A;  4Z7M A;  5D6F A;  4A6W A;  1B59 A;  2GZ5 A;  2P9A A;  4FO7 A;  2Q95 A;  2NQ6 A;  4U75 A;  5D6E A;  1JAW A;  2V3X A;  3IG4 A;  3D27 A;  1XGN A;  4FLL A;  2HOW A;  3PKB A;  2GG0 A;  2BWV A;  2BWU A;  1QXW A;  2EA2 A;  2BHB A;  1KQ0 A;  2P98 A;  4FUK A;  4FLJ A;  2GG5 A;  4IEC A;  4IKR A;  1R5G A;  1YW8 A;  2MAT A;  4IKU A;  4RZY A;  4U1B A;  5CLS A;  3PKC A;  3CB6 A;  2DFI A;  2GG3 A;  3PKA A;  4ZWU A;  1QXY A;  1C22 A;  1QXZ A;  1YW9 A;  1WN1 A;  2Q93 A;  2V6C A;  2GGB A;  1CHM A;  4ZWP A;  1MAT A;  2OKN A;  1QZY A;  3BIP A;  4PNC A;  2ZSG A;  2BHC A;  5CE6 A;  2OAZ A;  4U6Z A;  4FO8 A;  5FCF A;  4FKC A; 
#chains in the Genus database with same CATH topology
 2Q94 A;  1C24 A;  4S00 A;  5CDV A;  4U6C A;  2GU4 A;  1WL9 A;  3MX6 A;  4IF7 A;  1PV9 A;  2GA2 A;  3RVA A;  4S2T P;  3IU9 A;  2BN7 A;  2GU6 A;  3S6B A;  4MAT A;  1BN5 A;  4IU6 A;  5CDL A;  4U69 A;  2BWX A;  1KP0 A;  4JUQ A;  2BWT A;  4A6V A;  2EA4 A;  4RGZ 1;  3L7G A;  1N51 A;  3TAV A;  1WY2 A;  2GU5 A;  3FM3 A;  1R5H A;  4FLI A;  4QR8 A;  4U6J A;  1KQ9 A;  3ROR A;  2B3H A;  5CNX A;  5FCH A;  3IU7 A;  2EVM A;  1C27 A;  2EVO A;  2Q92 A;  3BIQ A;  4HXX A;  1XGO A;  2IW2 A;  2V3Y A;  3FMR A;  1XGS A;  1WLR A;  3CB5 A;  1A16 A;  2BH3 A;  2EVC A;  3BIT A;  4IDY A;  4U71 A;  2GG2 A;  1Y1N A;  4OOK A;  3PKE A;  3TB5 A;  2B3K A;  4ZNG A;  2V3Z A;  1YJ3 A;  3MR1 A;  4R60 A;  2BWW A;  2GU7 A;  1C21 A;  1WKM A;  2BHA A;  4U76 A;  2NQ7 A;  2P99 A;  4S01 A;  4U6W A;  4U6E A;  1W7V A;  4IKT A;  2GG8 A;  4U73 A;  4ZWO A;  5CDE A;  1XNZ A;  1M35 A;  1XGM A;  3CTZ A;  2GG7 A;  2BWS A;  1YW7 A;  1B6A A;  2BB7 A;  2GGC A;  4RZZ A;  5JFR A;  1R58 A;  5E5B A;  2GTX A;  1WBQ A;  4IPA A;  4S2R P;  3FMQ A;  3MAT A;  2BWY A;  1C23 A;  1YVM A;  4U70 A;  3PKD A;  3L24 A;  1O0X A;  2ADU A;  2G6P A;  4EGE A;  1WL6 A;  4KM3 A;  5JHU A;  2GG9 A;  2B3L A;  2BHD A;  1BOA A;  5CIK A;  3IU8 A;  4PV4 A;  3Q6D A;  5JI6 A;  2Q8K A;  4B28 A;  4IKS A;  1W2M A;  2Q96 A;  4FLK A;  4Z7M A;  5D6F A;  4A6W A;  1B59 A;  2GZ5 A;  2P9A A;  4FO7 A;  2Q95 A;  2NQ6 A;  4U75 A;  5D6E A;  1JAW A;  2V3X A;  3IG4 A;  3D27 A;  1XGN A;  4FLL A;  2HOW A;  3PKB A;  2GG0 A;  2BWV A;  2BWU A;  1QXW A;  2EA2 A;  2BHB A;  1KQ0 A;  2P98 A;  4FUK A;  4FLJ A;  2GG5 A;  4IEC A;  4IKR A;  1R5G A;  1YW8 A;  2MAT A;  4IKU A;  4RZY A;  4U1B A;  5CLS A;  3PKC A;  3CB6 A;  2DFI A;  2GG3 A;  3PKA A;  4ZWU A;  1QXY A;  1C22 A;  1QXZ A;  1YW9 A;  1WN1 A;  2Q93 A;  2V6C A;  2GGB A;  1CHM A;  4ZWP A;  1MAT A;  2OKN A;  1QZY A;  3BIP A;  4PNC A;  2ZSG A;  2BHC A;  5CE6 A;  2OAZ A;  4U6Z A;  4FO8 A;  5FCF A;  4FKC A; 
#chains in the Genus database with same CATH homology
 2Q94 A;  1C24 A;  4S00 A;  5CDV A;  4U6C A;  2GU4 A;  1WL9 A;  3MX6 A;  4IF7 A;  1PV9 A;  2GA2 A;  3RVA A;  4S2T P;  3IU9 A;  2BN7 A;  2GU6 A;  3S6B A;  4MAT A;  1BN5 A;  4IU6 A;  5CDL A;  4U69 A;  2BWX A;  1KP0 A;  4JUQ A;  2BWT A;  4A6V A;  2EA4 A;  4RGZ 1;  3L7G A;  1N51 A;  3TAV A;  1WY2 A;  2GU5 A;  3FM3 A;  1R5H A;  4FLI A;  4QR8 A;  4U6J A;  1KQ9 A;  3ROR A;  2B3H A;  5CNX A;  5FCH A;  3IU7 A;  2EVM A;  1C27 A;  2EVO A;  2Q92 A;  3BIQ A;  4HXX A;  1XGO A;  2IW2 A;  2V3Y A;  3FMR A;  1XGS A;  1WLR A;  3CB5 A;  1A16 A;  2BH3 A;  2EVC A;  3BIT A;  4IDY A;  4U71 A;  2GG2 A;  1Y1N A;  4OOK A;  3PKE A;  3TB5 A;  2B3K A;  4ZNG A;  2V3Z A;  1YJ3 A;  3MR1 A;  4R60 A;  2BWW A;  2GU7 A;  1C21 A;  1WKM A;  2BHA A;  4U76 A;  2NQ7 A;  2P99 A;  4S01 A;  4U6W A;  4U6E A;  1W7V A;  4IKT A;  2GG8 A;  4U73 A;  4ZWO A;  5CDE A;  1XNZ A;  1M35 A;  1XGM A;  3CTZ A;  2GG7 A;  2BWS A;  1YW7 A;  1B6A A;  2BB7 A;  2GGC A;  4RZZ A;  5JFR A;  1R58 A;  5E5B A;  2GTX A;  1WBQ A;  4IPA A;  4S2R P;  3FMQ A;  3MAT A;  2BWY A;  1C23 A;  1YVM A;  4U70 A;  3PKD A;  3L24 A;  1O0X A;  2ADU A;  2G6P A;  4EGE A;  1WL6 A;  4KM3 A;  5JHU A;  2GG9 A;  2B3L A;  2BHD A;  1BOA A;  5CIK A;  3IU8 A;  4PV4 A;  3Q6D A;  5JI6 A;  2Q8K A;  4B28 A;  4IKS A;  1W2M A;  2Q96 A;  4FLK A;  4Z7M A;  5D6F A;  4A6W A;  1B59 A;  2GZ5 A;  2P9A A;  4FO7 A;  2Q95 A;  2NQ6 A;  4U75 A;  5D6E A;  1JAW A;  2V3X A;  3IG4 A;  3D27 A;  1XGN A;  4FLL A;  2HOW A;  3PKB A;  2GG0 A;  2BWV A;  2BWU A;  1QXW A;  2EA2 A;  2BHB A;  1KQ0 A;  2P98 A;  4FUK A;  4FLJ A;  2GG5 A;  4IEC A;  4IKR A;  1R5G A;  1YW8 A;  2MAT A;  4IKU A;  4RZY A;  4U1B A;  5CLS A;  3PKC A;  3CB6 A;  2DFI A;  2GG3 A;  3PKA A;  4ZWU A;  1QXY A;  1C22 A;  1QXZ A;  1YW9 A;  1WN1 A;  2Q93 A;  2V6C A;  2GGB A;  1CHM A;  4ZWP A;  1MAT A;  2OKN A;  1QZY A;  3BIP A;  4PNC A;  2ZSG A;  2BHC A;  5CE6 A;  2OAZ A;  4U6Z A;  4FO8 A;  5FCF A;  4FKC A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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